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<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRB8</accession>
    <name>A0A1B7XRB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TTL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150782.1">
        <property type="nucleotide sequence ID" value="XM_018308464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRB8"/>
    <dbReference type="GeneID" id="28872571"/>
    <dbReference type="KEGG" id="chig:CH63R_13490"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13490"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="54444" checksum="927F93FABC2F87DA" modified="2016-11-02" version="1">MHAYIQPACPWLSEHIKTYIQRHVPETEFIDDFDDFPTDCSTIFQFCDGWALNRNFAVMNYAKKALINAYPNSDALARKDYLARVVEFWTAKRPNSILRGHVPLTVRLSLDYAEYVDEALTAADDLSLLYSLEENEDKPGQEREWWIMKPALVDCGAGIRLFSTMEELASHLELAEYETDEDDEGEMSEEGQEPIAQSASDLEQSNPVGFSPSLSTPGLDSLDALVTAIGAISTKSTSDGVQRNPKPQYVFKENGRIPSAQMREFVAQRYIVSIPPVENRKWHVRAYVLSMGRLTVYVFKEMLALLAGEDYEPPWMNPSLKSSLTNTALQDEDVFTEKESMRDFWAMSDDLLPGNWKAHVFDQVCSVSAELFRAAAHTMADKFTTVEKCFELFAVDFLIDTNGIAWLLEVNETPAFYDVGIAGPMALRLMDSVVCVAMEHMGKARLDDERNVAAKTRLISVLDETDKLAKSNITEILPESCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRP2</accession>
    <name>A0A1B7XRP2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major allergen asp f 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZPS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150945.1">
        <property type="nucleotide sequence ID" value="XM_018308627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRP2"/>
    <dbReference type="GeneID" id="28872734"/>
    <dbReference type="KEGG" id="chig:CH63R_13653"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13653"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000043">
        <property type="entry name" value="Major allergen Asp F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601005" evidence="4">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="299" mass="32161" checksum="38A8B55A9EB05175" modified="2016-11-02" version="1">MMYGFATAALLLSALTDATPLARRQASETVSVPAAAATPTPQAPYDWSAGWQKTFPIHQSCNVTLRAQLEVALAETQQLAAHARDHILRFGNSSEHVRKYFGNASTSTPVGWYDRVVNADKTGMTFRCDDPDRNCATQEGWAGHWRGSNATQETVICPLSFAIRRPLSSVCGLGYNVANSKLNTFWATDLLHRAFHVPLISEGVVEHYAEDYAEALDLAKNNASLSVIDSDALQYFAIDVWAYDIAAPGVGCSGELEEEDKEEPTPTTTAAGSAATTAAATSSAPQECHTHADGVLHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS84</accession>
    <name>A0A1B7XS84_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_13851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151143.1">
        <property type="nucleotide sequence ID" value="XM_018308825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS84"/>
    <dbReference type="ESTHER" id="9pezi-h1vpc4">
        <property type="family name" value="Glucuronoyl_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="28872932"/>
    <dbReference type="KEGG" id="chig:CH63R_13851"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13851"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601013" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="49327" checksum="498CB93FEAA062EF" modified="2016-11-02" version="1">MHATICLILPWAALLGLARAQQGAWAQCGGVGHTGGTTCISGYFCRYQNDWYSQCVPGSSVPTTGPAQPSPSSYSSTLQTSTTSPGGGPVTTPSATSTVPGGGGIACPALPSGLGASSSVLPDPFTFQNGGKVTSKADWTCKQAEISAQLQRVELGTLPPKPQSVTASYSGNKLTINVSDGGKSTSFAVTITKPSGNSVPAIIAFGAASIPIPSSVGTITFNNDEIAQQQGSGSRGKGKFYDLYGSGHSAGALMAWSWAVSRIVDALELTPSVGIDPRRLGVTGCSRNGKGAMVAGAFEPRIALTLPQESGAGGAGCWRIADWQNRNGFTVQDAKQIVGENPWFGPAFNQYTGSVDRLPFDHHMLAGLIAPRAMYVMENPDFEWLGTMSTYGCMGGARKQWRALGALDGFGYSQVGNHGHCSFPAAQQGELNAFIGRFLLGQAGVSTGVFRTDQTYNSFNVDSWSPWTVPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSS5</accession>
    <name>A0A1B7XSS5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PKS-NRPS hybrid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_14031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151323.1">
        <property type="nucleotide sequence ID" value="XM_018309005.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873112"/>
    <dbReference type="KEGG" id="chig:CH63R_14031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14031"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="14">
        <location>
            <begin position="971"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="2519"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="3737"/>
            <end position="3822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="10">
        <location>
            <begin position="971"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2421"/>
            <end position="2453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2606"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3844"/>
            <end position="3863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1377"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2626"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2653"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2678"/>
            <end position="2687"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="10">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="10">
        <location>
            <position position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR02805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="4196" mass="453758" checksum="B3B2E8BC27D0ED90" modified="2016-11-02" version="1">[encoded data, 4196 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSV4</accession>
    <name>A0A1B7XSV4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151353.1">
        <property type="nucleotide sequence ID" value="XM_018309035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSV4"/>
    <dbReference type="GeneID" id="28873142"/>
    <dbReference type="KEGG" id="chig:CH63R_14061"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14061"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="94" mass="9942" checksum="F53CD945AEF70C24" modified="2016-11-02" version="1">MQIPQAALPRTGAATVKTADPFRHSARFCLLLPAPTPDPARRVSQSCGSSNIRIIVAPVSPSNLTAGSPDHVVGMSPGRNDMTRRGDGTHKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTB3</accession>
    <name>A0A1B7XTB3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_14226</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151518.1">
        <property type="nucleotide sequence ID" value="XM_018309200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873307"/>
    <dbReference type="KEGG" id="chig:CH63R_14226"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14226"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="969"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="293"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="653"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="933"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="880"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR03000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1490" mass="164537" checksum="07628436D808B909" modified="2016-11-02" version="1">MSYHPPTMRSMFHSICPPGVDNDLGPLIRPPCRNGNDFTLVFEDLALTIAPSAILTLATLGRTPYLLRQSKKTQSTSTTVIYQYIKILAICTMAFLQVVHMLQWISLDNEPSYLSLSASLSAVTATTCLCLLSYLEHDRSIAPSPVITLYLLGSGLCDTPILRTLWVRQDNVLVPLARAAALLAKVVVFLLESTSKRGYLQAPYSQTSPEALGGIVNRSLFWWLTPTIQRGYRVPLELDHLPCLDPKLSVARQQNRLVQVWKHWRPLRSRHSLLFATFSCFRWQFLTVVPARVLLIACKFSQPLLINAAVKLLSRDDGVDKRDAGVLLTGAAALIYAGIAFSTAAYKHMIYRTMLVFRSGLIGVIHESSLLLDLATAKDTAAVTLMSTDIDRIMAGIEMLDVIWATPIEVSLAIIMLGRELGWACFPPLLISITCAIGSVYLGRLATKYQKIWIESIQDRVADTTHLLNNIKSIKMMGMAAPLAENIQQQRQREIDHSRAYRKVDTAQQVLGNTTLVLTPVLTFLLYYFLIHQRGGEGLDPAKAFTSLSLIVLLSYPIVYFVFALPRFTGSIGCYDRIQTYILSQDRDVQWSEDYDETESEFGAPCSHECEQVELESLLPKGTSIKSSKLGWVEVGGVTSPVFAADHTAGELVRIEDADFAFSADSASVLHSISLTVRQGELLLVSGPTGSGKSSLLLSVLGELRQCRGSTFRKPSLDIAFCTQEPWLPNLSVRDVIIGPSSFDNNWLSEVIAACDLSRDISRLSHRENTLVGSNGSRLSGGQKQRVSLARALYSRREILLLDDVLSGLDLSTERAVAHNVLGPSGLCRRLGITVMMAAPNAKYAAYFDSTFVLELGNLSDNSSNNPSPTVEHDLDKEQDLAEETEHESRPSGDGRVVGTAVEATPPTTQTSSGTGLPLYKYYFSTMGWGATLLVFASSATFVFCFKFPDLWLKWWTESESRRQETNTTLYMTVYVLLATVALIVLVSFSWSLKLVAVPRAAARLHQDLLSTTFAAPYYFLVAAGSGSIVNRFSEDLAIVDLQLTLALAKSIDGFFTIVAEASLIAYASALTALSFPPLLGVLYLLQKVYLRTSRRIRTLEIEARSPLLSHFIETLAGLATIRAFGWQRYWVERQRDALDRSQRALYMTYCLQRWLNLVLDLVVAGVGVTVMALVTQLPSWTTDGGALGVSLTNIVTFSATLTYVIQGWAQLETSMGAIQRIQDFTNQTPSENKPGENKELPPGWGLTHASVRFDGVKSAYSNCSDIILDDVTFHITPGQKVGICGRTGSGKSTMLLTLLRLAEVVDGRITIDNVDIARSRRDHIRSSVTVMPQDPTVFPGSIRYNLDPQRRHSDAEIKKELGRVGLSHILSSPRGLDATMTQSTSVSLSRGELQLFALARAVLRRHEGASLLVMDEVTSSVDSVAEEVIMRVVMESFSMHTVIAVVHRLNTILDFDLVFVMDQGRLVESGQPRALLESPGSMFRRLYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTH6</accession>
    <name>A0A1B7XTH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">B-cell lymphoma 3-encoded protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_14293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151585.1">
        <property type="nucleotide sequence ID" value="XM_018309267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTH6"/>
    <dbReference type="GeneID" id="28873374"/>
    <dbReference type="KEGG" id="chig:CH63R_14293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14293"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="582"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="737" mass="81998" checksum="BE9C302A49E04569" modified="2016-11-02" version="1">MKRHPREFRTWGYQDPVVARMDPLSITASVITLLGTVAASAKALEAVRGIQNAPKQVATALNEVTDLRAVVGMIEHSINDLSDDEKRKHKIICQSLYDLASKANGTLQELNTIIKKVFPKRTIAGSEEHVYVLSRRMWLREKSAIERHFLNIQSTRKNLDSALNSLNAARVGVRSEAHIVLQTSIEKLEESVMKAVLEQKTHDRALEPPSYEERGIPRNENSSLKQATSGISVDAFSNWGIEQCDDICPCDCHVKSTVEAPRWIRGLFGTLFYTYSGSPVFGRLPCNYIPCRKTGDGGHQYTYYFPSWWLARALYVSFSRQNLIGIGGSWTFSIPKMVDGGHPIWRFVNSGTVRQVADLLPKFGVSTCDINKDGKSLLHFAVEWKRQDMCSFLLQSGVNRFFEDLSGVSAAMMAWELVLPPDASKDLAHNTEVIQSLFKKDEVFDNLRFSKLHHALLTMTEESFSRELKLSFSLLNQQDALGRTPLAWAAAQGMPGKARQLLEVGAASDIVDKHGKTALHWACAAKAKEVVQILLDHDAPIEARDIIGRTPIWEAAHAPDSHEILALLVERGAEIDSRDDIYARTPLHLATYQGKSSNVTALLKLGADIEAKMTSGRTPLLNAIAYNQLSTLEILIKNGARTDAVEKTTGEGILHLAARFGPPKVMKRLQASNLEGVKLLARDAQGRTAAESFRLERPSSYYAEVDPTENVDQAFEDLCLRVEELEMEAKEFCGLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTI7</accession>
    <name>A0A1B7XTI7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151581.1">
        <property type="nucleotide sequence ID" value="XM_018309263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTI7"/>
    <dbReference type="GeneID" id="28873370"/>
    <dbReference type="KEGG" id="chig:CH63R_14289"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14289"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="86"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="255"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="461" mass="50009" checksum="066DAD76C235FD0F" modified="2016-11-02" version="1">MALTAEQQITHLRSLLDILTTSTNDLIAELSSSSTSESKAENGAAANHADVRVPADPKTEEARKRVIAATASLEAAVFTPQWRLGHLAHSYFVSRALHMAVEWEIPRLLATNGPMGLEALAAATGVVDTRKLGLVMRTLCAHHVFAETALDVFANDEASAALASDERLANSVRYASFLFPTADVLPGLLKDPALCASYASRDSAFARSIGKGMGQFEYLNAHPEWRDCFNLWLASLGEYLHGLTDVGGYPWESTLRNGAVVVDVGGGLGSSIQALRANFPDRRGRDDFVGIVQDQPGMIEHATAHWQKTDPEALATGAVKLTVHDFFHENPVKGADVYWFRSVIVDWQDDDLTKMFTHIRNAMAPGKSRLLIGEYIMHPTCGDALLPNAPSPLLKNYGEFQAMGLISGFILTVSPNGVQRTVRDLSKVVEAAGLKIVKVWICRGLGHVIECRLKEDAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU41</accession>
    <name>A0A1B7XU41_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argininosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151803.1">
        <property type="nucleotide sequence ID" value="XM_018307386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU41"/>
    <dbReference type="GeneID" id="28871493"/>
    <dbReference type="KEGG" id="chig:CH63R_12412"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12412"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="3">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="21104" checksum="6D2F726CE710D70B" modified="2016-11-02" version="1">MALAKDPERLREVIKRAISAELGFDGLLWNSMADVADRDFVTETLQWGSILMQHISRCPEDLIYSSREFGFARLADAYSTGSSTPTAWMTVSDSIQIAEGVLATLDTQTEEMKAALDPFMLATDVAYYIVRKDVLFREMHHISGRCVVLSERTGITMNDLSYEQLKTVNERFEEDIAEYSNTRGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUD6</accession>
    <name>A0A1B7XUD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151884.1">
        <property type="nucleotide sequence ID" value="XM_018307467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUD6"/>
    <dbReference type="GeneID" id="28871574"/>
    <dbReference type="KEGG" id="chig:CH63R_12493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12493"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="344" mass="37392" checksum="4A63C83A88209A54" modified="2016-11-02" version="1">MATSPPTIYLAVSQKHTLSTTPETLEALSQQCQKASKQDPSPDLILFPEAYIGGYPRGATFGAAVGGRTPEGREQFLNYFKDAADLGDTPEGAGEKWVKRELEGQEEGGAGRVRRGDGTREYLERVARETGIFIVTGIVERAGGTLYCAVVYVCPKLGVIGKRRKVMPTGSERLIWGQGQPSSLRAVTTSLRGVPITLAAAICWENYMPLLRHSLYSQNVNLYLAPTADTRDTWPALMRTVACEGRCFVLSANQCLKKQSQPAWVYGEKSESEEFVSTGGSCIVSPLGQLLQGPLWEDEDGMLTVGVNFDDCVRGRLDLDVAGSYSRNDAFKLTVTGLDISPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUF9</accession>
    <name>A0A1B7XUF9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151896.1">
        <property type="nucleotide sequence ID" value="XM_018307479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUF9"/>
    <dbReference type="GeneID" id="28871586"/>
    <dbReference type="KEGG" id="chig:CH63R_12505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12505"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="429" mass="46538" checksum="5F13B81B691218B9" modified="2016-11-02" version="1">MKPAKRVAVIGLGPAGAIAIDALAQEQAFDTVRVFERREAPGGCWYRAEKVRRVPNSAAAAAGGGEGEVEEKEGKEDQDKEAEEEWKLTLRQSDPASSTDSWWEERFDALVVASGHYSVPYIPPTPGLAAFAASRPPGSVIHSKHYRGRAAYLGRTVVVVGASVSAADIATDLAAVAREPVTAVVLGHTPNGYFGAEAFEHPLVRKAPSIARVDAASRTVHFVDGSSVSGVDDIIFGTGYTWTLPFFDNPPPSLPPRPGKETAAAAPLPTPRNNRIPNLYLHTIYTPDPTILFVGAVNAGLTFKVFEYQAVLAARLLAGRVPPDRLPDAEAQRAWEADRVASRGDGPRFALVFPDFPDYFETLRRLAGPPTDDGKGRRLPPYNPFWFERFMAGHERRKAMWRRLNAEAREALGGEPRDGGQGDVARAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVK5</accession>
    <name>A0A1B7XVK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152340.1">
        <property type="nucleotide sequence ID" value="XM_018307923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVK5"/>
    <dbReference type="GeneID" id="28872030"/>
    <dbReference type="KEGG" id="chig:CH63R_12949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12949"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="82" mass="8835" checksum="783345463834160D" modified="2016-11-02" version="1">MGMRSNDRYRGLAPGSWIGGLADTVQFNGSTGSVHGKPHVACQILPTYAYYMQVVVLARRVEEHSFRVQGGLASAIVWGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVU9</accession>
    <name>A0A1B7XVU9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152386.1">
        <property type="nucleotide sequence ID" value="XM_018307969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVU9"/>
    <dbReference type="GeneID" id="28872076"/>
    <dbReference type="KEGG" id="chig:CH63R_12995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12995"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601130" evidence="1">
        <location>
            <begin position="18"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="279" mass="29649" checksum="2075A7465523C219" modified="2016-11-02" version="1">MRCSTLLVPSLASLALAAPTYPTLNLQAALPGFIEHISEYFNMLATKVQATRYLSAAPVCDLSAAKLPQCERRKHFQESTSADLPSAAIETLGEPEQGLSLMHIAIGRGTQNYTCDTKNATAVPVATGAIATLFNASCVGSLYPDLLDKLPIVAMDFNLTEEEVSRRLGPSNLAISGHHLFTGAGVPLFKLEPDGSPIGDAYCAKNGSMPAPLTAQTGQHGEAAVAWLRLKVIEPSSGGLREVYRIHTVGGSAPASCKGQSEAFEVQYATQYWFYSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYA4</accession>
    <name>A0A1B7XYA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">And nb-arc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153281.1">
        <property type="nucleotide sequence ID" value="XM_018306440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYA4"/>
    <dbReference type="GeneID" id="28870547"/>
    <dbReference type="KEGG" id="chig:CH63R_11466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11466"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="316" mass="35037" checksum="628D535666E2EA1E" modified="2016-11-02" version="1">MDKAQDNKQPPTAPPAVDRFNVPDIPPQDQGLKVLHDPKDVDAIDVDIVAVHGIMANPTSTWKHSKTGTNWLADPLMLPESLKEHGVRIMAFGYESKWFGRGSVRQSLSNLATDLLQALNQKREHCPQRPIIFIAHCFGGLVAQKAYTMAALQEGDYPGIWKSTKGMMFLGTPHSGVNDGTNLTKQGQIYDAIVARKLEVQDNVLLTVARDNDVLVDAVSEFARKVSTSAPPPMLFSFYELKPTNLGAIVGQKFVPEFVVGQSSATLLGHEKQGLALDHFGINKFEDNQDNNYQKVSWRILKMVREAKVDSLNSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYD2</accession>
    <name>A0A1B7XYD2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153283.1">
        <property type="nucleotide sequence ID" value="XM_018306442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYD2"/>
    <dbReference type="GeneID" id="28870549"/>
    <dbReference type="KEGG" id="chig:CH63R_11468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11468"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1046"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1126"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1161" mass="124407" checksum="9EAE616FDB976B36" modified="2016-11-02" version="1">MATFIKRTASLSPSIVSSFSSLHHQRREPTEQEYERVAQLMAEQRQEDGNRRSGEYSHKEATPVLSKLARGAVPDATPGLAQALLDWGADVSIAKPKSTNFFKMLSGKDQSEERSDVLEQATRNCDADILIVLAQDADEQAVNQALPAALRLADTVKTGILLARGADATPHCDLFLLCVDSAPVDMVMLLIRDVKGACGSCKNKGLVRAAKAGSVEKANLLMDKGADPSFNGAAALFEAIRMGKDEVALAIISRPVMKKHPSLLTTAAQSALDHGRKKVLQACLDAGSENSTAQRQEATLQSQVTFNSPVDSRLAGTSSIEAAFMQAANAGRLDTIQQLLANNRADTLPQGVMVKLLTQSIDLPDLKTAHTLVDMLLSTGGLRGNTVANSLCRILSRPVPPANETDRVQIVQLLLGKGSADVNVGRGKAVLQALSQGRLDILGMMLRHGASAETFAVAMNASMKVAVPRDRLAAVKVLVESGNVAASESLQAAAVAAASRSAALDVLQYLAEFVTSPGVFSTGIGALARECDDWTSPRGLYVAQFLLDRGASGPEVDGAMARASGLYTRDAVQLLATSTDPASFDQVLGFVIDASPHWQLRQNLWLVHSLLEWGCKGASVDRALVRAVGAHGEEHDLQLLIDTLLLVGIGADVNHEGGRALQIAVGRGHASLVNKLALNGAGRLALTNAFQAVITSRMDEATALNLLDILVAGCERSRTRFDVDAVLADGRCPLEACISTHPRAEKLGRRLIKLGCRTGTLVSMKLDGGEERVPLLVWALYQSGQGAVAPSLLTAMVDSHRDVVKYRSASGITPLIAAAHLGSNELVGKLLGAGARPNERDNAGRTALFFASAAGHMAALQALVKAGAAQNDGSLHEAARNTHSEAVAALIKAKHEANFPSSLHEGRTALQELCYRCSCGTIYPELEDTIRALERGKADPFAVHAERNALFLALENARPYHITKAFLDVQMWRHVNDERNVFFCADPAAAAPSTAGYVCSATLYLRHGLYRGDPQHVPRLLALLAEKACQDRFFARFGPHQLEALQPPEAVGVPPALADEDARRRAAQERRRARDRDHADRLRQEQEGAAVKAEIEGRQHRLRLERQQQTSVLQAALAAQQAEVRNARRQSQQTPVAVVGNRNGVVARAGDQGRQSRLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYM2</accession>
    <name>A0A1B7XYM2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153362.1">
        <property type="nucleotide sequence ID" value="XM_018306521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYM2"/>
    <dbReference type="GeneID" id="28870628"/>
    <dbReference type="KEGG" id="chig:CH63R_11547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11547"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="285" mass="32670" checksum="93ECBC27169D4838" modified="2016-11-02" version="1">MASDHGCSDNDLAGLSIYEVAHRFAHQFPRKRFVVEPLQWTASHLVFLRCAFVEVTPNTPPSGPRPTKEKPWAPKKKITRKQAFQWVADCNHSVFSPVMPLQSLLEAYSFKSVRDCPLVFFFNKHKILLPCEMVSTGPHRKSWKQDHCRIAFSQIHTAIREPRRRRFPLQLEKLGILPENPHVDPYIAALLIAEAQQSQAGSTTLSENATESCYKVHFILADYDDRKNIRVYSAVISTAFLRKLSHPNEKPRSPDSTRFDIRYTTLPYRPKSTFPSRLVGVLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1X8</accession>
    <name>A0A1B7Y1X8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_10117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154515.1">
        <property type="nucleotide sequence ID" value="XM_018305091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1X8"/>
    <dbReference type="GeneID" id="28869198"/>
    <dbReference type="KEGG" id="chig:CH63R_10117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10117"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="178" mass="19306" checksum="703B97AA6BF28AC7" modified="2016-11-02" version="1">MAAVQERSQQRSASGPSQTQTETQSRTGTHAILRLRGAHAPSRQSVRWAEDVVDNEGLGRKSSKVCCIYHRPKGVDESSDESSSDSSSDSSDSEADDGGKRRIPSGDHKGKGKGGKRSHDHDCGDHDHDGHRHGRKDSRGGKEKKTRRPSPNAYERVPKPFKPKDEAGEGSKGPDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y238</accession>
    <name>A0A1B7Y238_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154601.1">
        <property type="nucleotide sequence ID" value="XM_018305177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y238"/>
    <dbReference type="GeneID" id="28869284"/>
    <dbReference type="KEGG" id="chig:CH63R_10203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10203"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="327" mass="35787" checksum="62F4A40005CD408E" modified="2016-11-02" version="1">MQIAQLQVSNTPSLSSPRRSFDLEPLQQTLPSRVSSPPKTQLSKMLIKESHVDVPTKADGKEGSMRIFLFHPSIPGYPNAKFPGVCVFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHDFAGPEPLAYDVPGTDKGNAWKVEKTLESYDEDSRRTVDYLLTLPTCTGKIGSTGMCLGGHLAVRASLDKRIASCVAYFATDIHSRTLGPHTAKNTSPTPPEGSTHTLDLFPTLAHAEVAMIFGVKDTHVPPEGRDLIRAKLREAGVTTSFYEFAWAQHAFIRDELSKGRYDPAITKVCFEILLELFGRTLKLDLGPQEGVGEVEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y261</accession>
    <name>A0A1B7Y261_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154604.1">
        <property type="nucleotide sequence ID" value="XM_018305180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y261"/>
    <dbReference type="GeneID" id="28869287"/>
    <dbReference type="KEGG" id="chig:CH63R_10206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10206"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="120"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="661" mass="73173" checksum="A2C0575EB9688D7A" modified="2016-11-02" version="1">MADDKHVGAMPSGDFSASNIEKARRGSQATVDLNANVDAKIRNPLLGISRAELIRDVDAFAHEKGLQEYIPVLRKGALVAQDPTGFEEIDGDEALNQAEVQVLHDEVLHKWRVPKILYLTIITCSIGAAVQGWDQTGSNGANLSFPTVFGIGGTSHHDTLLVGLVNSAPYIGSAFIGCWLSDPLNNFLGRRGAIFFAANFCLWPVLGSAFAQSWEQLLACRLLLGIGMGAKASTVPIFAAENSPAPIRGALVMTWPSHKPSPPEQYMLTTWPEMWTAFGIMAGTAANLAVAKTGAIAWRLQLGSAFIPAVPLALLIYACPESPRWYIKKNRYPDAMKSLLRLRNHPIQAARDIYYIHSQLQVEAEIIGRSNYAKRFLELFTIPRVRRATLASFTVMIAQQMCGINIIAFYSSTIFKEAGTSEFNALLASFGFGMVNFLFAWPAIWTIDTFGRRSLLLFTFPQMAWTLLAAGLCTLIPGTGGAHLGMVALFVYLFAAFYSPGEGPVPFTYSAEVFPLSHREVGMSWAVATCLFWAAVLSITFPIMLADIGVIGSFCFYAGLNVVAFVMIFFWLPETKQRTLEELDYIFAVPTRVFMRYQLREALPYWFQRWVLFRRDATLEPLYKFDLTHEDHHGSETYEKAQVEQRDKKSGSATGVDVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2E5</accession>
    <name>A0A1B7Y2E5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT hook domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154711.1">
        <property type="nucleotide sequence ID" value="XM_018305287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2E5"/>
    <dbReference type="GeneID" id="28869394"/>
    <dbReference type="KEGG" id="chig:CH63R_10313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10313"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="696" mass="73261" checksum="A08E20E7D64FD153" modified="2016-11-02" version="1">MAPPRVIADSDDSDDGFDLGDDSPMKPPTPKIPSGDRSSDSASVATGSTDPKFFQAIYAEQQRAAVDEALSNHVRSSTSDNPSSLAAPAKPQAKKDSTTTTTTTSSSSLPTIPDPVMGSHRAKKAEKTRVVVDLTQVITPGRSNNATPRDMWDVPSSPASDQAAPVFPISSKARTPCSNKKRKRGDKMEATSPLATGIPSQGSTQPFDATPATRTNAVSVHEAKRWRLGNPESSLPAEDDVDMVVPLDVADVPSFRDLVSGQKPISLCIEPPQTLSASQRQEYKYHSVDPSQEDQAPVPTQPFSALPATARSSGATTIAYSTPSQTRVVGRPLTTFADHTTLDTVPERTQETSKVALDPEATVEILSSPDIISAAPARRKRGRDDDKAYKKVETHQANASWDSDGTGFHCKTFRPRTSRKVAGDGCWQDQTEHREETNVPAPDMGAAAQTPTGESALASLPKAKRRGRPRKSEVAAVASTVAIEAPAPPQATESDDVAKESAGVEAGAAGAATPQTKKKRGRPRKADKSAMASGRQGADEQSPAEVEGSHTSKHMDVEMDETPTKGIQAREPVKRGRGKKGDQKPGLTTTGVAGTSPTTDGSQVRGEDLVLQPVTPNVDSKSGSGGPDPQSAATEQKAAANCALVGKGESKTEEVLGKADGKKSSMAPASSAGKPIYRVGLSKKSRIAPLLKSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y311</accession>
    <name>A0A1B7Y311_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154912.1">
        <property type="nucleotide sequence ID" value="XM_018305488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y311"/>
    <dbReference type="GeneID" id="28869595"/>
    <dbReference type="KEGG" id="chig:CH63R_10514"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10514"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="598" mass="63971" checksum="FB219EBFB369C3FE" modified="2016-11-02" version="1">MRVRMKASRHVIFAAASVVSAELHGRQTGTIGDSYDYVIVGGGTAGLTLASRLSSDPSTSGFAPGTRYDWNLTSVAQESLQGQVVNLTQGHAVGGSSTVNAMIFDRGMPSNYDAWAALGNDGWDFGSLLPYFKKSERFTPASPENTALFDMTYDPDCHGFEGPVQSSYLAWSHPNNSLPYPDLSNFLNAMEGLGISTPDDQGCNPLGAYLTTHSIDPRNQSRSSARTAHYDSILGRANLHIATGQQATKVLFDTSGEKPRAQGVEFSAGPDSVVQRVTAGKEVIVSTGALNTPKLLQLSGIGPATVISQFGIASIVDLPGVGANLQDHPFGLTLASLSDGVPGNYELDNATFDAEQRDLYYSERRGRWTDTIAEALAFIPLFNFTTLEAANRLLSAIDGTSFLPPGTDETVVAGYEKQLEQLHRMHQSRSTAGMELLYVDGGRSVVNILMHPLSRGTVLINSSDPFLPPLIDPRYFSHPYDGQVLVESLRFNRELLATAPIQALGAVETLPGAATQSDEEILTFIKGVTSTEFHYSGTCAMLPRALGGVVGSDLKVYGVDGLRVVDASIMPLVPSAHTQATVYAIAEKAADMILGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3K7</accession>
    <name>A0A1B7Y3K7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155106.1">
        <property type="nucleotide sequence ID" value="XM_018305682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3K7"/>
    <dbReference type="GeneID" id="28869789"/>
    <dbReference type="KEGG" id="chig:CH63R_10708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10708"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="34454" checksum="B4E0E02D3727A5CA" modified="2016-11-02" version="1">MTAPRPWTPPLLLRIRFTTAIPDLDLDIPSPSQTTVAALKHLIRGRLAQPDSQRRLRFIHQGKILPDASALSSVLRPLPPPPPAASQPTTPSTPGAAFDDPKGKGKAKVNETAPPQRVYVNCSIGDSLTDDELAAEAEAALRAPSERGPSTNSSFIDGPPHGQHGSSYNLHHHGQQQRPTPRGFDRLLNAGFTAAEVNQLRLQFREIRSTQYTPDTMPSPDTMRSLEDSWIDSNAGSALPGAAGAGGEGGEGAGGGDDAFGAMSGILDVLIEGLIVGFFWPLGCLGWLSREENMLSGRWQDFIGFGVTLSIIIGVIRAFSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3N1</accession>
    <name>A0A1B7Y3N1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRI11 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_10749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155147.1">
        <property type="nucleotide sequence ID" value="XM_018305723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3N1"/>
    <dbReference type="GeneID" id="28869830"/>
    <dbReference type="KEGG" id="chig:CH63R_10749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10749"/>
    <dbReference type="OrthoDB" id="4843860at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="33034" checksum="2C24971D2AE4DE89" modified="2016-11-02" version="1">MIAEFSFGEALNAIRSWSKGHETPIVSKNDKKATFMPLWTSEAWVKNKDPERKSPFPNLINVMVSAGVPTQTALSEAKENLGPGTDTTSASLAHILYALSRNTTYQKKLYQDLARVGFPTDMSALESIPRLKACVKEGIRWAGAAAAMLPRVVPEGGVELCGKFIPEGTVVTSSPIWYLRDKYAFPNPELFDPYRWIDETGTILTENPIRDKFYVPFSKGPNICIGNHFSYFELFLSLAKMVESFVLIHADEDGGGLAQAAGLINSDWQPVQLPKRKEWVAAVVTEPLLVTAIPRTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3V4</accession>
    <name>A0A1B7Y3V4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155209.1">
        <property type="nucleotide sequence ID" value="XM_018305785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3V4"/>
    <dbReference type="GeneID" id="28869892"/>
    <dbReference type="KEGG" id="chig:CH63R_10811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10811"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="606" mass="62844" checksum="D75ECF9880BF486F" modified="2016-11-02" version="1">MAERLNEKAGSGETVQANDPGNDDAQQNGARCEHADKTPTAEVDEGTTQETTQGTTTSATGADEGKFPKPAVIALLAAGLCTVVFAMAVDNTILATAIPRIADDFRSLDDVGWYRSAYLVASTALQPSLGKVYTILNVKWTYLAGLVVFEVGSVVCALAPSSGALIAGRTVAGVGGAALYSGAVNILALAAPLRMRPLLFSLLTGMFAIASLVGPPLGGVFADSPALTWRWCFWINLPLGAFAFAVILGVFRVPSARKLEGSDPESKRLRQGTTESGGPSGTVGSPPLPPPPPAPSLLQKAARFDPLGTLLLVPAVVCLLLALQWGGTKYAWGDARVWGCLLAFGLLTIALVSSQLWGGDNATLPPRVMRQRTVIAGALQMACSAAAMFAQNFFLPFYFQVVLGTTATGSGVLILPYVVTMAVIGIFAGAGMSQVSSYKPFGWVGTAIFVIGSGLLYTLKVDSPTASYIGFQVIIGVGTGIAWQVPFVAVQRASAKGKAIKASDGPIANALMAFFNSLGASLGISIAQNVFASSLQNRLAAVPGITAAQIATIMNAGTGVGLRDPNVLPSEMLLPVLTQYNSAIRSTFIVATVFSGLGFLASLLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3Z9</accession>
    <name>A0A1B7Y3Z9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155274.1">
        <property type="nucleotide sequence ID" value="XM_018305850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3Z9"/>
    <dbReference type="GeneID" id="28869957"/>
    <dbReference type="KEGG" id="chig:CH63R_10876"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10876"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="15100" checksum="F57B59476845F9E4" modified="2016-11-02" version="1">MAAIAMGAQPLRMASLLPRISAPAFTQTSRIFSLYTRQVTSSFLPALSFALPAFNLNVPAWLGGIWESILRAVPKKKTSHSKKRHRQMAGKALKDVKSLCKCPGCGQIKRQHIVCPHCLSKIKDLWRDENPSGKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4S7</accession>
    <name>A0A1B7Y4S7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155567.1">
        <property type="nucleotide sequence ID" value="XM_018303544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4S7"/>
    <dbReference type="SMR" id="A0A1B7Y4S7"/>
    <dbReference type="GeneID" id="28867651"/>
    <dbReference type="KEGG" id="chig:CH63R_08570"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08570"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="7">
        <location>
            <begin position="289"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="496" mass="54364" checksum="8F645CE6D965AEE7" modified="2016-11-02" version="1">MAATDSPLVNGHKSDKKSKKDKKEKKRLREEDAEAGEERKHKRTKSIGVAQDDDDDDESPVASQDLSLAALTNTTNGEPSPEKKKKKDKKHRKSVGDAAEDASDAERKEKKDKKKKRKSQHKEAEDDVEGSFADAAATPASEKKEKKTKKTKAATPDPVAENDDNGDAMDVDSPAKTKSTSRVHQPPDAPSKPSFPFFTQTVSLYLPLYPVGWDTPCTAAASQHLEPLVNRYVPELKGVLLAFRNVAVSEQPGRRHAATNDSEHCDLVSVDEYAVGFGYVTVDVDLFLPRRGAWMEGSINLENEGHIGVVCWGKFNASIESARLPPEWRWVHAGSAEAASYVADPFDNDDDDNASARAAEDEHGAVRQIHTTGFWVDGAGDKVKGRVRFRIKAFDVGVSGDHGYLSLEGTMLDAAGEKAAIQHDADQERRRRAGKSGGILSKERRRMPEFSVTKFGVVEDEEDKALRQDVWNTTEPVTDNEAGGKEAFTGISAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4V9</accession>
    <name>A0A1B7Y4V9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155589.1">
        <property type="nucleotide sequence ID" value="XM_018303566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4V9"/>
    <dbReference type="GeneID" id="28867673"/>
    <dbReference type="KEGG" id="chig:CH63R_08592"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08592"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="456" mass="50262" checksum="7CDC6CA224EA1236" modified="2016-11-02" version="1">MNPMRSRKRRSLELETRGGKLRIGIVGAGIGGLMAAVALLESGHDVEIYEKSRFKSEVGAAICTPPNSSRILAHYGFDFEQARATTSEDSIYFTDPSDLGQKRVVPCADFTPKYGAPFCFFHRVDLHSELRRLATEPTDKRPRSARLHLGTSVTGVDDDGTLWFEDGTSVRKDLVVAADGIRSAFVSRVVEEAPRAQHHMSIMRYLVPSETVLADPEVAGFFVDGLKSLRVVDNVDKRVIIYGCRGGSLQNIGLIYPPRLGMDAAGTSNLARPPAVKCLFVAHSSFSPSSRAGNDISESEGFASKVMAEFPETIQSICREAKDVGQWQLFTRAPLERLARGRVVLIGDAAHPMPPLRAQGASMAIEDAAALGVLLSQVESADEVPARMDMFNKLRWCRVAATQLLSSEHRWDPSQLSAEQRGYFSGDVPHTEDDVEKYSYEYDVIRDALELLKEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y580</accession>
    <name>A0A1B7Y580_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155673.1">
        <property type="nucleotide sequence ID" value="XM_018303650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y580"/>
    <dbReference type="GeneID" id="28867757"/>
    <dbReference type="KEGG" id="chig:CH63R_08676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08676"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="187"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="319"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="644" mass="70054" checksum="1DDFB1A4459CAA9A" modified="2016-11-02" version="1">MKHSTANTGFFQELPVLPNQFFEDSSFQRVLRLFLPSDVVERVEVELAQLGEDVLSDRIFSWVTDSERNKPYLKGNGRDAFGRPTSELVVGEGWRGLQDFGIRKGIVATGYDASLGSSARMVQFLRLHLWGGSASNVSCPSAMQDGAARLLQLHLAKDADPTQRKVLENALQHLLSRDPATAWTSGQWMTERTGGSDVSLTETVARYTPSTEQGLADEQEGIPLGPWSISGFKWFSSATDAAMTILLARTQNGISAFFAPTRRHSSSAATMVGRPRGVAGTELNGVRIQRLKNKSGTQSLPTAELELDGMRGWLLGQEGRGVHEISTVLTLTRVHSAVAAVGYVGRGLAIARAYAKVRQVHAGQGRRMPLSESPLHMQTLADMTGEYHGLMLLTFFTAHLLGLDEHPDTGVGSGAPAALKLDRKHVAPLLRVLTPLCKAYVCKTSIQLLQGCMEALGGVGYMLKEETEYLNVARLHRDCCVLAIWEGTTDVLATDFVRALKHPQGGARSVEALDALFAENDRPGQGSSSVENGSPNDSWRAVRRELGGSSQPELVAHARYILWAVAEALIGLLLHMDYGRDESAAAFDLLCRRKVRSTRAALGGPSSKGGAQDETRLSSEDRLRRNTIIVYGRLGSDAARRTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5G9</accession>
    <name>A0A1B7Y5G9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_08822</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155819.1">
        <property type="nucleotide sequence ID" value="XM_018303796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5G9"/>
    <dbReference type="GeneID" id="28867903"/>
    <dbReference type="KEGG" id="chig:CH63R_08822"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08822"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR07301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="166" mass="18920" checksum="48D597A193DB8565" modified="2016-11-02" version="1">MSLCQNRLQEERSPECTISSWTSLTGYRKQWRKDHPFGFFAKPQRNAATGTLDLKVWECGIPGKEKTIWEGGLFKLTITFPEGKFVPPLFHPNVYPSGTVCLSILNEEEAWKPAITVKQILLGIQNLLDDPNPESPAQAEAYSLFKKDKAEYEKRIKRVVRENPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Y8</accession>
    <name>A0A1B7Y5Y8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155914.1">
        <property type="nucleotide sequence ID" value="XM_018303891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Y8"/>
    <dbReference type="GeneID" id="28867998"/>
    <dbReference type="KEGG" id="chig:CH63R_08917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08917"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="262" mass="28708" checksum="9F156ECAB462FA0C" modified="2016-11-02" version="1">MAGRPARLKSSQHTLWLFIPSSDQVALFRVPLLADQPSFDAYTVKSSVPQLNAMYLSTQAAVDPNVELYESCTEDTGVLASCFTSCPLLTPTPGYVGGIKRALRPADPSAFQYWPANIPASFTMINQSSGWKKLPLQRIARTRPSVIRGAVPPAVHWHSADSRLHTLSGSFAALAKAKIFVDGEENRNNTSIAFVLVALTATATATKTKPIYSAKIRSRPNWAVWLLAVSERLTRNHKPGVVKINTLVLYAKGCTYDYGVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6E9</accession>
    <name>A0A1B7Y6E9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156130.1">
        <property type="nucleotide sequence ID" value="XM_018304107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6E9"/>
    <dbReference type="GeneID" id="28868214"/>
    <dbReference type="KEGG" id="chig:CH63R_09133"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09133"/>
    <dbReference type="OrthoDB" id="3550599at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="34994" checksum="C9D7EC09E935E7F6" modified="2016-11-02" version="1">METKHKYLRAYTRAMLHKVIPYGGKGRTGEALNPISLGSSEDEDEEDAMANDRKPRRTKPSYGQDQDAAFSAESQHLGNENRPLITGKYDQQRTETNRLRKRLNCEERRFQLCATFDSAKFDAMVYGQANAASPPEGVVVPTAPINGSTNTPSSGENPEQLYMNFDPRIHWPHNRSNEWYKLKMEEIKARGGRKANFGKAAQRMRQHRLEAERRTEKEMWAIEQGASVSTNKQPQPWSHHRHMDFGDVPQEELPAYVRKNPEWMHATAWMRENREQNLRRNREAAALRAAGLPWEHLFPRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6P5</accession>
    <name>A0A1B7Y6P5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156187.1">
        <property type="nucleotide sequence ID" value="XM_018304164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6P5"/>
    <dbReference type="GeneID" id="28868271"/>
    <dbReference type="KEGG" id="chig:CH63R_09190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09190"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="446" mass="50319" checksum="25D2267A16F55CF7" modified="2016-11-02" version="1">MPPLDAVLEVLRWAKCTFSRAFTKKAKLRWTLAHQNYLRVQSISQILPLQKFEDICRKVYFAVDSYSEIDFVLTTGFLSYMFAEHTVSEGSASFRDHFQLCQRSLAKALSLLPIMLPPSMEVIAALTFGAMGHGDEQRNTETSLFWTVFKFEKGLALRLGRPSGIRDAEITLLAEPDEPRTTRIARIQGQVYDRLYSPAGLPILSERKAQAMQLADEESLKDAQADHMRATYLHSDLVCHSSILTLILRAVPSAQRSGITDECASAARDTIEAHRQCIESLRGCSDPATVVKYLNWCVSFLSDMHGWLIFMRRAIIHVPFVPFSIIFTCVVRTFNFDDLALLERFAASLKPETTDENSPTHPYRLYDLLCQAARLHITRTQFSASDPNMTGDDSTLLSDFEASQFLAETTGPIDDFVNPDLLMFDASDWYQGNQHFIGLLDEGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7R5</accession>
    <name>A0A1B7Y7R5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156486.1">
        <property type="nucleotide sequence ID" value="XM_018304463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7R5"/>
    <dbReference type="GeneID" id="28868570"/>
    <dbReference type="KEGG" id="chig:CH63R_09489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09489"/>
    <dbReference type="OrthoDB" id="5378718at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040887">
        <property type="entry name" value="AUDH_Cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054583">
        <property type="entry name" value="Beta-prop_AUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22301">
        <property type="entry name" value="AUDH_beta_propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18637">
        <property type="entry name" value="AUDH_Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldos-2-ulose dehydratase beta-propeller" evidence="2">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Aldos-2-ulose dehydratase beta-propeller" evidence="2">
        <location>
            <begin position="204"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin" evidence="1">
        <location>
            <begin position="511"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="802" mass="89253" checksum="1BDFBAB824664805" modified="2016-11-02" version="1">MTSADFAVPEFGRAVIEGDRTDGYWVETFKFEKDEVPGLVASGLASGEIEFLDNPIAAARHAAKAKGESFDPSTVDITGEWKKYQVAKFSSPVAVVAVDINRNGLTDIVVCHDYGPFMLECDVNGGWISWLENPGRDKLGEPWKIRMIGRWPAMHRMKAGYFTQKSVMEIVAASVVYGQHDKVCCWSAFNFEVMQGFFLTVVVTQVTPIPIIRFQAPEDVLNATEWQRSIIDDENFTVIHELTVKKFNGPTGLDSIVVSSREGANWLYYEGGEWKRQLLSIGEPKEDRQLPNSQAPGSGDHWGTGCADAGRIGDDPFAYIATLDPFHGTTACVLSKVGRGMKDSKWQRHILDVYGTPNQLMKYGDGPGHYIICADFDGDGDDEFLLALFGSLDRDKDLNSVIPVKGPNPNKVSNKTMTLRAVTLQAFESLTTSQGIMYYKAIDVEKGLFAKWKIAEESSARIAIGNFSGTDRLDLISVEYNVPRYYEEPKPVITLHVNKFAKPKPAVTERHIVPTVWDNEGLVYLARPSEVKSPQSFPLIEVANYAISVEIHPPGARIPLGQNDGVKVLYGSVADIEGTRSALGLPSFPRIASVQSEDRDLSADKEKGVVLLRLVSVREQPEAWAKAEDVPVKTTFNTSELGLEFPELKFTKVEELWWGADFKGVDFTNMSGFYFRFQDDKSQIAHLQFWTAGPNVDCGVHNHGNDIFQEIHICLSPGTEDGGMWRLREGKDPKAARPDDFDKVALPRLNEHGGLWYRDSYGDAVRGHNNVVSYPWHKWQGGSKGKNVDVWLALEFNPGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y882</accession>
    <name>A0A1B7Y882_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine pyrophosphate enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156666.1">
        <property type="nucleotide sequence ID" value="XM_018304643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y882"/>
    <dbReference type="GeneID" id="28868750"/>
    <dbReference type="KEGG" id="chig:CH63R_09669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09669"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF133">
        <property type="entry name" value="BENZOYLFORMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="207"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="428"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="639" mass="69747" checksum="CD6E0C60C7522B31" modified="2016-11-02" version="1">MERIVAETLPPGPPHRWARDYLFDVCRDLGITRIFGVPGVNEIPWIDGTSYPENGVEYVQCLHENIAMGAAMGSARMTGKPAVLIVHVTPGIAHAITNLFNASRSQFPLVILCAQQQNALVVQEPLLSSDTVTLARNYCKWAHEMKSEDDMKLVLQRAFKEAMAPPNGAVFLSMPWEFTMRRIPEGDYLKGITRISPHFGPDPESVRDLAGRLAAAKNPIIVAGDAVGLAGAWAELRDLADAIGAPVLQQTLSAVANYPNDDSHWQGELPNNQAGMQSAFEGHDVAFLCGFSNQAQVLVYKPSDGPLIPDSVSKLYLSNCIWDIGKNYYGDAALFADVKVALPQITALVKEVIAPLVAKQRNDTLATLADDRKKQWGRYLDLAMTQDNVWAVVIADALRRQIEQHQLQRDFVYIHEAISDPSPFQYLLPYAEPTSYYCVGGGSLGWSFGATLGIKEEKRGVQGIGTKLVVAVTGDGSSLFYPQAWWTAAHRNLGILYIITNNTEYHTLQVGLGSIVQVYGEALGYDWTPRTMDPGYLTIRDPQPDFVGIAKALAGIEGKHVDHPAEVEPAVSDAIRYVLETGKSFVLEIKTVGLSSQQAPPNTNDAGAVTPSLRKQPHLDMVHSGPNSAREPGDTALIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9F3</accession>
    <name>A0A1B7Y9F3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Radical s-adenosyl methionine domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07369</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157122.1">
        <property type="nucleotide sequence ID" value="XM_018302344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9F3"/>
    <dbReference type="GeneID" id="28866451"/>
    <dbReference type="KEGG" id="chig:CH63R_07369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07369"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="65"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="371" mass="42028" checksum="5E1F0FB29532A81E" modified="2016-11-02" version="1">MGILTSFVQMALALFSTIPYFIWIIAVLGVAAAFLFRRGAEKHHIRSPEAGTTEKSTPPQVADDPDAPVSVNYFPSRECNYACGFCFHTNTSGYILPLDDAKRGLRLLKEAGMRKLNIAGGEPFLHPKFLGDLLRYCKEVLDLESVSIVSNGSKIQEKFLREHGRHLDILAISCDSFVRETNRAIGRGENGQADGDHVAQVFRIAEWCREYGIMFKLNTVVNIHNWDEDMTAQIAELAPFRWKVFQCLIVEGENEDETRVRDARRFLISEEQWKTFCDRHKHLPCYVPEDNQTMAGSYLLLDERLRFLDKGDGPMKKSDSLLDVGVKKAMQQVAWDKGAFDKRGGVYEWRKPQNVGDNGGCSGGNKKELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAQ2</accession>
    <name>A0A1B7YAQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear pore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_07725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157478.1">
        <property type="nucleotide sequence ID" value="XM_018302700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAQ2"/>
    <dbReference type="GeneID" id="28866807"/>
    <dbReference type="KEGG" id="chig:CH63R_07725"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07725"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="812"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="932" mass="104852" checksum="264ABFE99170EDBF" modified="2016-11-02" version="1">MPPRLKDGVKVAVQERCLQVWSEKQALRMLRPIVADIDGTQAERLYFHRFRRVADAGLCNHVTNLTSFWSRLAPQLSHSDEAVKHAIVALGSAYHIYQTAPPPGGDGAPPGELEIFTIQQYSTAMSKLSSYAHVPMKDRITVTLLCCVSFVCIETLRNNWRPALTHLTNGLRIIESLPLSMLNKLRDPLPSRDGTGATESMSGMDYILRLFATWEVSCALFAENFKPVISIKLYKGRELDDTPLDEFETIMQAHQAIVQYTRDVFALVWLTREHQGDDKFWSQPLPCRQHEILMDKGDYLTGLFERFMERPQAPASGTEEYYSVCLDMLHYKCARLLCQTLHQKPHQRRQSPDIVTQHAELVSIATLLHRGLAAKQRQTDTLPRSFTLDIGIIPPLYFILVACQDPAVQEKALGILRDYPQRENLWDGNAVRNLLVTVENVPRYLLPRSMLYACLPTCLPRVGGGKCPYSLLRVSCSPPDWLQHHLRELSLHPRRALQSSSSTPFQRCKMAAFHHDIPAIAEEKTGFDLNVQHGHQDLVQAVAFNAYGDRCATGSVDGKIKVFNRHKDGVWHHCDTWGAHGGEILELQWLPPTVYPNLIASLGIEGRFKLWAEDPSAAPGRRFSASNRATTSKAAYEMRSPKYPYRSFSMKHNEETRHTYLALLASDGRLVVYENEQPENMSEYTPTDEFSICPKPSRGEEISFKVRFDPNPDPCYNALRAGVSSDSLGLVVAGMSSVKVYRSRDVITTSYGVAQTQREFYLAMEVGVHRGLVRDVAWAPGNIRGYDTIATACQDGFVRVFRIDTPYSGDGKKWHTSELTKRENHHAQTSSKTGQPNDKHHQSGLSASLAKSDSHAERHFSGQPGQVKHIVEEVAKLDSHHTPVWRVGFDDDGQILASTGDDGKLVCYRQTPRGTWAKSSELAMVKTKMVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBA7</accession>
    <name>A0A1B7YBA7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_08148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157900.1">
        <property type="nucleotide sequence ID" value="XM_018303122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBA7"/>
    <dbReference type="GeneID" id="28867229"/>
    <dbReference type="KEGG" id="chig:CH63R_08148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08148"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="390"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="689"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120001" checksum="A792747E68719A1F" modified="2016-11-02" version="1">MSSTASSATRTVLGGGGPAVSNGSGLHSFAMGGDGAPAGRGGRPPLPHIDDLTSTSPNIDMNLPLRKILEMGDNAMRQAETFRDFGRPDMAFKEYIKASLIAVKYVPMHTESVSVKGGRGDLNRVYTALMKKIDSHHGNFEKIKADIIADNHRTGVRPTASRPSSIRNGEAIRPQTPRSPPVTSPTRAEAATQLNGSPAAKQKPAVQPKPVSLHGNALRSGTGGPNLPKSKAAEDLAARFANLRGPVALPGQDPRIRTHPIMPPRPAGPRAMPEPPEKPKVAVVTNLPDLPKMPDAIYSPARGTVSNEAASLPSSTPRGLFSRTGSSASINTVLANSSNNKSSEYFVSSHTTPSAAPIASRAPSIMIPEGDSITAEGLMNYIKRGSATLQVLIIDVRSREDFDEGHILSQAVICIEPSILLRENISSEQIAESMVLSPPQEYHHFERRDTFDLVVFHDQDSDSIPRYMSPDMDAAALLSLQRALTYFNYGKELKNPPKLLQGGLDAWTDLMGRGALATSQTAGAMRAPLARSPLKPTISISKPNRKYKVTPLKPEEVKLWEETLQNAELETARSPGFMHVRSTEEFLRRFPAVSAEQESMQSPVGPEQSAYGYSQNHVDLYSDLPSPPTRPAPAVPRPSYSGLSQTQDDHEGPGAIAFSAQGRNAKQGPLARPDSPSVANAGKDGLRITGLNNPGVWCYANSSVQALRMSPGFGKELATFEWQNMYKVPKKTDEKNDHPQLMSRILSNLFHWLDSGKFDVMKAQTLMVSLFLSHRMRTVSNRMQDYSRSVCEKSRHKDRGDEFGGGRQQDAHEFISWLMAYLHDETNVRRDRSSTDTPAPTPAPSMGGKSMLQGAYEWWAQYQKKNASMVDKYWRGIELSTVVCAQCKNRTYTWDTFDFLSIPVNRNTHTLEDCLRAHLETENISDYQCDSCKTKGLGRKQARLARMPELFCLCLKRFTVDNHGGVKKDLSRVTWDFNNFNVDEFFIPPEERTAGSAPDGNFELPFDYECYAVIIHSGPNINSGHYYAYARDTHNPDPTVWYKINDSYVNSIRIDGTGRTGDYSEKVFKSSGEVPYMVFFRRKGGRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBD2</accession>
    <name>A0A1B7YBD2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157844.1">
        <property type="nucleotide sequence ID" value="XM_018303066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867173"/>
    <dbReference type="KEGG" id="chig:CH63R_08092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08092"/>
    <dbReference type="OrthoDB" id="4848543at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="954"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1313"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1344" mass="151210" checksum="59C31E84E835F5CA" modified="2016-11-02" version="1">MAGSSSPDPPLADRGLLEYSPGLHESHSNRPSPKSSRQNDTPVVRSPFAESEPGFLSQLGSSTTTNASRDTDSQYHINRLAGRGSKSPFYPAQNELAFEAIESFSFAPQPKHKPNQFSGLQKQRNIDFEALEAPVAETGSPSVDRASPDHDNPRIVREEAAPMNNLDHHRDVSGTQTGDSARRRHQEKNPQSISDAKDPNAAQSGLEHAGNQAEMTTHHTHGRADAKYELYQTEDKTSRPRGNIVSRRLNSTMGRELISRPFADADAILPVAHQLSSHVSRDTSDLENNSTAFHFSHRGGTDGTTRHPQATGRAMETTSPAKISRPSDCNTVKRSSREHRQHASVHNKRHLEPAETRSRTPVGDLEMPQTRTPTTGHNQRRDSPREQPTRPLSHEEQRDPIPRGTISRQSNISRHKRSRHHQERQNQSSRGELPFKNRAGHQPGQTTYGQSHVQKSHFDVLKSIMTHHNMFLEDAKLTEANLKCEIAGQEQHIEALGARLESSHLQCQQEQDRRQALESELGFLQQQKDKLAAIAAKSSDRTQELENEVSRLQAQSEQDNIATIRLENELAETKSKLSKLQEKSRGYKDYLNKAVIEQQKLWQQSKDISQKAIDDMRKENQESEEKLRLALKKNQEVQDDLDQKFNNKRAALHQELNAAVTSIRSLESAMERLEGDLNAESIRTRDCEDQLRESRHQEMLLMRVEESIERISDKMDRLNVFPEHSNTVPTSITERLEVIAGYVQSAPRADVGDEIRQALKTFQGEMMSQFLQEVKGMMARQSTIEDKLQSLENSIQHQSTSDQTDRREQEKPLEQHSHKREKNKGFHQLLQSKEAQVVEMTTTVAELTRELQDIGAYTELASKNAMTSEAALQILQVRSSNREHQILETQAPFQIQREDRETTLAEPRERLRHAEEYVSQRSELVKDSHSKMATAKDEFAAMAQEKQCELELQLRHSEDSCRILQQQLSESEAEIKRLKALEDGSGELRLQKELDNAQQRITNLTLKLRETQTPAVDAEVLDQLADQLAQLHRMKDEIKQLKTSGKTYTMVSRELVAMLHGQDAVESDTILAPDSLVVPEMDLPELPHNASNDPLKTPVFSSSEPPPVQSGKRTVFRSPVEEPDYDAPAPSVAQEKFQRKEATSQGPQPKPILRQKRMALGSSNTPRMPLVTRHAGHSSYNRPVQGASRTSEAAISDVRSNLVGNRQAQVSELTGHDDWQRMTAQGSQDGQQGAKRSRSVSISLSFRRQKRSKPSFPVGEDAEASAAGGSSGLNSPKVELSQQSDGGSTQASQEQPQDKDHTSRHFHPSMSKSDADHQENVRGERVSQQKQQQTEVKEGEELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBN1</accession>
    <name>A0A1B7YBN1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157775.1">
        <property type="nucleotide sequence ID" value="XM_018302997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBN1"/>
    <dbReference type="GeneID" id="28867104"/>
    <dbReference type="KEGG" id="chig:CH63R_08023"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08023"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="359" mass="42027" checksum="A662EECE141D98E3" modified="2016-11-02" version="1">MGSRQPEFEQQFQTALLEFRELRRQQTRTSARGQQFVLVNNVTARLRQRSPSCPAIYNDDLVRIAQTAYLREKLNPPRLRVREFDNCLEVFYNLLDINAPSLIHEFWNNNLTTLPIELDALRKHIKPPRDYPDFHDKFYESQFAWCPIRFEMDMGTSHRHSIHNIISPFSRKEKIKPYRDGKGPRVNTATLYAVEVPEELVGPRLQKQMASAKIERQENGTDSFGTGEERYRFALKQFNSSKREHFINEKEMFINLENKEGMIKYIGWFQSFEPDDRGGLEECWNIVLELADFDFYTAIRKESPPISAKEILGFWQTMAEISGALASIHTVVVDRQQYLTYVSRCLFFASIGSILTMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YC85</accession>
    <name>A0A1B7YC85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferric reductase transmembrane component 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158163.1">
        <property type="nucleotide sequence ID" value="XM_018303385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YC85"/>
    <dbReference type="GeneID" id="28867492"/>
    <dbReference type="KEGG" id="chig:CH63R_08411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08411"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="319"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="715" mass="80808" checksum="C4DFE164FFA41E55" modified="2016-11-02" version="1">MLLSSDNLPGIFIGLSGLSGVTGMEFGVPGYGLIGYSITMYQNMLTSHKPLCAYSCRVALSASPLNCSSRTEVNGMVFANTSSSCFATDDAFLMSLAWCIHIDMTRTWIRSLRVTLKRCVDLSVWEIEKYWQSTEASIRNSHRRLDEPGVNVDSNPPAPKWTYQEALSNVNRTPTATLSFANPLKEKALVSDADYQVQYNTMGMFEKMEVNHETYGLILIASGAVVPILISLLRFVPLPALMVSKIHAVFIDPPLLGRRHKVPYFNMLIMPTRGQTILIAYLVIINVVLSGIGYDSAQPNAWWVNDRDQELLTSFSNRMGVLSFANLPLLILYAGRNNFLYWLTDFTQSTFMLLHRWTAYFCTIQACLHSAAWLQIYVSMNQHDIEAQLPYWIWGIIATLAMSFLLPASAIPFREKLYELFLALHITLGILAVVGSYLHIVYRFQHQWGYEVWMYICFGVWGFDRLVRMLRMARNGLLWANINIIDDDYLQIDIIDAVGNGHAYLYFPTLSWRPWESHPFSILRSRVNFFSTRSSSIRPCPVTKDSFSKDSSSRETSHANTESRVGLSFLIRSFSGTTKLLRSHSRLPVFVEAGYLPHHNLEKFETLFCIVGGVAITAVAQVLHTYPGNAKLYWSARSHTLVQRVSLDGVDLSISIDARFELRSVLEEEIRKAKGTTAIIVSGPATMVDEGRCLVSKLAFRAPVPITFIDETYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDC2</accession>
    <name>A0A1B7YDC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158407.1">
        <property type="nucleotide sequence ID" value="XM_018300557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDC2"/>
    <dbReference type="GeneID" id="28864664"/>
    <dbReference type="KEGG" id="chig:CH63R_05582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05582"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005720">
        <property type="entry name" value="PRK07538.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF268">
        <property type="entry name" value="5-METHYLPHENAZINE-1-CARBOXYLATE 1-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="49194" checksum="1142540F274B12CA" modified="2016-11-02" version="1">MPFLDSQPKIIIAGAGIGGLTTALSLHAAGFTNIHLFEASSQLTTLGVGINVQPSAVLILRNLGLLEALEKTGIKTQELNFYNRHGHPILSEPRGIKAGYAVPQLSIHRGECQMLLLSAVKERLGEDAISLDHALTGFSQDSKSITAEFSRRRDGAPAEQSSVTGDILIAADGINSTARRILYPDEGPPRFSGRMLWRGCLERAPYLTGASMVWAGHADQKFIAYPISQRSADGGKSLVNWIAELRIRDKDDEDLTPPRTDWSKAVDKSVFESRFHGWRCGGLDVKDLVDKTDKVFEFPMSDRDPVERWSFGRLTLLGDAAHAMYPIGSNGASQAIIDAETLVRLLSESPDDVEGVLKAYEAERLPATAKIIFANRGNGPDHVLQVCEERAPDGFRNVYDVVPKDELEDIGRVYKRVAGFEMESVNAKAKETEGASERLRLESPKDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDM5</accession>
    <name>A0A1B7YDM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158674.1">
        <property type="nucleotide sequence ID" value="XM_018300824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDM5"/>
    <dbReference type="GeneID" id="28864931"/>
    <dbReference type="KEGG" id="chig:CH63R_05849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05849"/>
    <dbReference type="OrthoDB" id="3538943at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="541" mass="60026" checksum="51731A556C7DBCF1" modified="2016-11-02" version="1">MAIKNGTRLSRLWSEPDGLLHRATLHQTNGKLVFPEELIHMTFDLYGTEIAGTTSHRARTTEEVSRGSSRPASRRESLTQARVPNPSPPESPAAVQAAQEALVSQVVRTHQRRVERIPQPPLEVTGKTFAQAPLEAFRSAYPSYSGSIDDFVKACLTIKDLRRKLLLPKWLYDDFIRAFVDGFVPYIETLDDDEPPLSAYQWYVEHVDRPTFEGGIVTRENLHQVFKVYHSEFKSAKESVLVKTSPNLGAGQMPSFDKAELQLEKGPQATVAQTFEPTEARPENHEARRTSAALSLLPNQPSSVTAQEANKGPAIGPHASIKVKDHGLMSMASRTPLPEGDKGKQRLPIKEHPILWDAPASAPAIQRHRNALPRDGDITFVSSTPRPRTANSNDASSFNNNNDRTHDDRFLVTIPTTQTTVRKPMLSEWKDAIPARLDRNDIVAETPARGSAAPVKTPTQHPAVRRSLPISFTPTTPSASLPSVESLRGGTPKRTLSDNRIKKPKNETEEERKKRKMRAKLEKMAKEGRLAPPPSSMAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDT2</accession>
    <name>A0A1B7YDT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Negative acting factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158689.1">
        <property type="nucleotide sequence ID" value="XM_018300839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDT2"/>
    <dbReference type="GeneID" id="28864946"/>
    <dbReference type="KEGG" id="chig:CH63R_05864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05864"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="63870" checksum="9B8F4B0CA5258AC8" modified="2016-11-02" version="1">MVNTGKPSGGCKLCRARRIKCDEGKPFCMRCRKSRRQCPGYRDPFEANIRDETEATIKRFKKSRGEDDSEDEGKDIVPICNKQCLKTVAGPKYKTLDYSNPAAFPYHDDDDTTDEDKDIPASMFDSLDEQASCYFLSEFIIVPCTPAARGYYRFLPRFLSGPKVSKCLSQAYKAVSLAALASRRSVDAGAAMFHAQGHYVRAVRAVNKAIMDPQEVLNDQTLGAVLMLAFYEMLTSSRDSITEYINHMKGAAIMVKLRGQNGLETPEGEEMFAITRNQCLSIHCLPNSPEVSEFTWLLHHECRGRMQHAIASMDIQSSKIRQDVDRLLKAGDRKPETTQKVLNALRRAQALEAKFRRLNNDPSPQWKVDTIELIPELSEEKLDAAECFTGPVYGFFNLPLAILHVATWCCHLMLTTTILRCMAWLVSPNDYRLGEEYEELKRSAQLRIQDTIASTPYFCKWNGYGVVVAQFPVGTTRPDDPLKGAAGLMILCPLFTACSSDFATHQQRRFLRGRLKYLAELAGIKQANVFYNVSARIQLTPLPQIWPLTPGDADTGLDERRIVPVSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDX8</accession>
    <name>A0A1B7YDX8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158790.1">
        <property type="nucleotide sequence ID" value="XM_018300940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDX8"/>
    <dbReference type="GeneID" id="28865047"/>
    <dbReference type="KEGG" id="chig:CH63R_05965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05965"/>
    <dbReference type="OrthoDB" id="5062850at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="506" mass="58417" checksum="D9185EEF62DE4F52" modified="2016-11-02" version="1">MLSFFKFPRELRDAIYRQYVTFEGGYVLNPETNRMRGAVNDLPVDLALMYTCKRVAEEMKGLPLKANTLTFSTFYPPEHRVHAGYFHLAMRELHGNLDAFVCLLPRRFLHEDIQAEITDCYPKYEPVIEMMRTKRDAHREVIPSGPFGETPSTHRSFIRFVLQTLSFYRFRFNDEFGRLCDNAGQSPMDIARLIDYSPAPWAIPTQQEVEEMLWLLYGTHTFEEDASYGLWDNDSNPGLSKFRYSAVAVAIRFLESVTPAHRAQIRHIKLMEDRESVSNPECHALGLIPFCRENPLLRVERHISLWRNVFLHHTAYKTFFDRLRFEASLEANEISGAVALWIMEALALGPAGMPSGSFTLVLDGDGDTRCSEIFQTVVLRDAAWQEAMDECYSRGILPPQPWAKRRQNPRSRGDGPGGVAYEKAANHSYLYEGFPQAIRDIVNGTSVVRCNFDPGEYEDVEQLIETRKTWTLAEWKGKWYERVTKSFEPSPPLPSWKDILREFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEL9</accession>
    <name>A0A1B7YEL9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158861.1">
        <property type="nucleotide sequence ID" value="XM_018301011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEL9"/>
    <dbReference type="GeneID" id="28865118"/>
    <dbReference type="KEGG" id="chig:CH63R_06036"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06036"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601581" evidence="3">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="396" mass="42755" checksum="D04B0C0396B055B0" modified="2016-11-02" version="1">MPYGPVVTMHALKVVASAVLLRGVAAVPAPSLVARADVLAPTAAWVSVNNKGVPTTVTPVPTTVSGTPTLEFAAPNALTGSVFTFVDSRLHVSTSTGSPPLATANHKNGAGAFAPCSNTKGDFSPFCDPVKGSQLYVDGTYYVTWDPTVLIKGNKTNVHVKIQGKEVNGTKVGDTVLNADSDKTNPGAWGYYAWHVSKNLIHAGQENATIELLMSYTIDNIAQKDITGPRVVVARRPQFHPETSRMPKGAELYVALPTVFGVVILAVIGGCLWNRRARQIGIGNVMSRSRHGYGVGKSRAQRLGARVRQSVFPRSRKDRGIQLRQQREMSPDGGYVYRDEPLDSQHQQQPAGRPRRDSDALGSLAGSPTSTHFPDHGAQGGNAFREELRRQERERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF56</accession>
    <name>A0A1B7YF56_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159196.1">
        <property type="nucleotide sequence ID" value="XM_018301346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF56"/>
    <dbReference type="GeneID" id="28865453"/>
    <dbReference type="KEGG" id="chig:CH63R_06371"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06371"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="430" mass="47783" checksum="A5AC76F9619260B5" modified="2016-11-02" version="1">MFLPQELLYLRYQNTPSSGFIPQPVAKMPYNTRRKSLSLPSLGIHVPGSHPSRSPAVVTPNRTVSENLGSRITITPASYPNKRLKRSLGDDGSRHRHASHKRPDEQVMLDHKPPPSPPPENIEMQDATSDGLAMKQIDLDRINDEVVEAVIIQLQMTCNRPHLVRELATVLSQQVPIVKNSANPCAIISSRLTAYLKRSCWRALAPCPLGKEQETVHPRRTYFYLTTSPRQPFPDSPAYIQRAVISPSLSSISSGSEDGEDVDLRRRELSPSPEVDLSSHELDEGDDDFAMPTTPVGSLPSSLRYSRSHRSASPPLEKDEREFTQTADGLQKRKLARELSLTGSVEHSTNAYESARDDGMFDEKHGAAVGNGTIPTHQFINSPVIKASVPSSARKENDSESWFKLGSLLEWDHCPENIELDELDCLLDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFJ0</accession>
    <name>A0A1B7YFJ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LEA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159343.1">
        <property type="nucleotide sequence ID" value="XM_018301493.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865600"/>
    <dbReference type="KEGG" id="chig:CH63R_06518"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06518"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1348" mass="142239" checksum="87E6D27CFD0B0CD8" modified="2016-11-02" version="1">MQSPHEQLHFLRYPVSAEYNEFISQHEQELQKYHNKNNKNNKNTIMVGAASKSGSSMLGGRGKEAEQKSTYSVEQDIQDHGENLVAGVIGKTGEVVDETGKTVGKVTEGEAGELVGNVVTATGDIIGKDGGVIGKALPLGELTEGGESKEGGGGFSIMGATKGVKGIVDTVDGTVQTVNRTLPLVGDLTRGIGLGEGQGGVLGGVLGGGQDEKGSQGGLLGGITGALGGGQSEKGGSEQNPLGSILGGVLGQSQSGGPLGVLGGNEPLERDQSVTDKDEKLTELLAQQKSEAGDKASVTENAKQNLFEVNDTTSEVAPIDLKDAEKSQADDGKPTTGGENTQTDTEDSQGDKTDLTEQSTTDGKDDLQEVDAEPIDEQTEGAETVKDDATEKAGTVPDDIATLDVPVSQIPDDLKSELPEDLQTADIPVSQIPFDAQSKLPTDLASKLPSNLGSAIPEEGEEAKSGTETPKDTTTEDWANLQNPANQSQVPEDAQTGEFPKTEGAEDAVEGAEDTAEDAKTGDVPDIDVTAASDSAPKSTVKDDIKSVLSTVRSAIPEDQRTVTVAGDKLLQPFEKFPGAEIDDEGKVIFDNASIGRIAEGDPADLVGMTIDAEGNVINERGSIVGKAELKSEVADELLKDTIDFSILKGAKVNKAGNLINDKGEAVGRIVSGILKHLVGRKADERGEIWNDAGKVIGKAEPIPETEREELAEPAPFEDFPGATVESNGHVLYNGDIVGRVIEGDAKKLKGKKVDDEGDILDKSGNAIGKAERWEPESEPEPEPEAPVVVDNSALAGKRVNKAGNVVDKDGTIYGRIVEGDVKKLIGRMCDKEGNVRSESGDIIGRAELIPESDREGAKEGPFAELPGCTVAKDGTIVTPSGDIVGRLVQGDAKTLFGRPIDEDGDILDRNGNLLGKAERWEPEAAPEREKGPMEGRKVNRSGEVVDADGDVIGKLTSGEVKACAGKIINEDNDVVDSKGRIVGHVELLEDIPEPKGPLEGKTVNKKGEVVSDSGELIGKLTTGDISVCAGKKINEDNDVVDSKDRVVGHVTLLEDLPEKKGPMEGRRVNRQGEVVDEDGNVIGKLTTGEVSICSGKEINSDNDVIDSKDRVVGHVSLLEDIPEPEVEEEEVETEEQKKAREEAEADAKLARSLGGLIEQGLDRLRPICKMITQKIEAAERKPKEERDEEQLVKDVKPLIEEGGKILTELNGSVRALDPDGRIQQNAKAKAQTREATPEEHHLAEVLKELTGTITETVEGAKRKIEDMPHAKSELNPLWGLLTEPLFQILAAVGLLLTGVLNLVGRLLNGLGLGKIVDGLLGTLGLNRLLDGLGLGSLTAALGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFL3</accession>
    <name>A0A1B7YFL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159394.1">
        <property type="nucleotide sequence ID" value="XM_018301544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFL3"/>
    <dbReference type="GeneID" id="28865651"/>
    <dbReference type="KEGG" id="chig:CH63R_06569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06569"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="121"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="646" mass="71610" checksum="2DBA75BD8AB35815" modified="2016-11-02" version="1">MAQHEKGVDTESPVHKDGVQHHDDAGDGRKKSIAELTQNLEGEIKNPLKGIPKAELLEQVTAYQRAHGLPDDILPLLKKGALVAQSPALFESIEELDEDERQALREEVTNRWKHPWPLYYTIILNSIAAAIQGWDQTGSNGANLAFPVALGIPDAAGSACGPVANEGDCARNSWIIGFVNSMPYITICLFAGWISDPLNELLGRRGVIFVAAILSLIAPFGMAVSQTWGQLAASRMLLGIGMGLKEVTVPVFSAENSPTLIRGGLVMSWQVWTAFANSERGIFLGTCANLAVGKTGEIAWRLQFGSAFIPAVPLVLGTYFCPESPRWYLKKGRHAKAWGSLLRLRNTPLQAARDLYYIHSLLEYEETLVREAGLRVTSNMFTRFVELFTIPRIRRATWASGIVMIAQQMCGINIISFYSSTIFKESGISDYTALWASFGFGLINFTFAWPAVWTIDTFGRRTLLLFTFPNMFWTLLAAGLCYLIDKDNENSTARIAAVATFVYLFAAFYSPGEGPVPFMYSAEVFPLSHREIGMSWAVATNNFWGSVLSLTFPRMLIALTATGAFSFYAGLNLVALALIFLFVPETKQKSLEELDYVFGVPDRTHAAYQLKTVLPWWTKRWILQRKGAACPPLYHDENAESRDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFL4</accession>
    <name>A0A1B7YFL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159363.1">
        <property type="nucleotide sequence ID" value="XM_018301513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFL4"/>
    <dbReference type="GeneID" id="28865620"/>
    <dbReference type="KEGG" id="chig:CH63R_06538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06538"/>
    <dbReference type="OrthoDB" id="4678449at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="517" mass="55352" checksum="8A8391E371B3BCC8" modified="2016-11-02" version="1">MDEQNQDTISRRNLRRSALGKECIFSVARPRPQDQDLRFGSRPGPKAHDRFIHVDPAMYRTGSNSTGGNVDNISNNNNNGQQASKERSAGPSWRQNHPDAYGEDARNGGFHGCWPDTLPPLHHHHLPAASIPSATAAPITRPPSQAASLTLDRDVDMAFQHAERASSSGQSEAHLSSVSDEGWYWNNVPDFSDNAYSGSSADIYRAVSDDFALLVSRGGIPPPHEEGHGGRDKSRQQQQQQHAPAPGRLRGHDVVVGGGVSFLFRLLLHRVLLRAAAHAEPVRPQHVEGGPAAGRPGRRRLPDPVRVLHDLPQLHGPVGAAHHGLRALPVAAAVRAAADPQHRAARPPAAEPAGPAAAAAPRLVVVDASVAIDIARPLRRHQDRGLRGRERGREGGHRRAPAEGPGGRSDGLHRRPPRAASAHGHAGSGGKAGLDDGEAEAARPGVWLTGNMSTGWGSVTGADPDMRTTARQLCFRSCIAHNAAPVASHTWAPICQKGTLGWKPCRMSGGYDRRDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGJ5</accession>
    <name>A0A1B7YGJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159521.1">
        <property type="nucleotide sequence ID" value="XM_018301671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGJ5"/>
    <dbReference type="GeneID" id="28865778"/>
    <dbReference type="KEGG" id="chig:CH63R_06696"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06696"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="470" mass="51287" checksum="0CF73B2737703205" modified="2016-11-02" version="1">MAIGRCREVARNQMPLSRTRIPSCIFKRKSGVEKATAENHGAMLRGARAGTGEGDVFRGRRRLARPVASGHVYLGRDTKVISRRDGCQPAMDADESRCRPMEVQPKAAPPRPRPASSFGRDGWHGAGQAETNSANGVRLSSNGESSECHPVTASVPCLLTPGVFLRPVELPRFSALRRRQDIDNTETENPYRRASAVTEPGERRWWLEWLGNVLGWLDEGCKKDSLTGAPSPGTETQVTGTYRKGAYLAKMLMLFFLLDIRLGPSSPSFPARKEETSGTPNKVHKPPPLGLEKPAAAAAAAARSRGSGPGERNQQFYPHAGLMRPSSEHGSQVQEGIKPHITKLQSWKKATKASRTSDHVAVIPIGEVDLQHLLEEGVSSHAGVGRPHARPQERYATRGKLWALRSRWIPPLVCDRRASPIPFVKSGIGGNREVWNPSTYSISVMAAVTVTAAWTSPIGEPRGFLKIPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHD0</accession>
    <name>A0A1B7YHD0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_03688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159909.1">
        <property type="nucleotide sequence ID" value="XM_018298663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHD0"/>
    <dbReference type="GeneID" id="28862770"/>
    <dbReference type="KEGG" id="chig:CH63R_03688"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03688"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="49"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="401" mass="42136" checksum="7069B4C52A47A867" modified="2016-11-02" version="1">MSATESLRIPPYTATVQVSIIDTTLDGTLPTAPFMGPPIRGFETWHGVGYAFLVTRTDAQGGRRRVVFDLGLPTDWANDFSPPVIEAVKQMGGAMTARKYVSEILTENGVDLEGIEAVFWSHAHPDHIGRLSLFPASTALVVGPGVKEAYFPGWPAVPDAPVLAREFEGREVRELDFSRGGDASGAAAGLEIGGLRALDYFGDGSFYLISAPGHAVGHINALARTTAAGASADGGSSGSSSSFIYMAGDSFHHASVLRPHAGATLPEEVRLPGFCCAGRAFHAVHPLGGNAAALLGPAVDGRDGDADADSTAFHTIPGTEAGEAPLALDVGEARRTLAAVRRFDASPDVLVVAAHDDSLYGVVEFFPREASGWRGKGWKESGRWLFLRDLRTPVEMAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHG8</accession>
    <name>A0A1B7YHG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_03815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160036.1">
        <property type="nucleotide sequence ID" value="XM_018298790.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862897"/>
    <dbReference type="KEGG" id="chig:CH63R_03815"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03815"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601671" evidence="8">
        <location>
            <begin position="18"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="915"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1393"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1293"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1508" mass="158921" checksum="2BE185BE83CE9D42" modified="2016-11-02" version="1">MAFKTWLLTALVGLANGLASTDTITWGGDNSRAGYQTNHNMDPSVVGSSQFGQLFRTLLPGRYGNVPEQIFSQPLVYTPDGDDTQYVYVATTQNNVYKLNAKTGDIVASRNLHLPFLTADLDGCYDIQPHVGITATGVIDPSTNTVYYTAKTYADQTQPNVAQGRPAGRYYLHALDVNDLSDRPNFPVDLEGTVARNNPIRSFNGGIHHQRPGLLHVGNYVYAGFASHCVQYNFTGWVIGWDKTTGNIVERFATQGDGVPANVEGAGIWMSGGGLSSDDAGSMFYATGNGYASQLSTIPVKGREPPTALEEAAVHMTINEDGSLTLVDFFMPWEKQALDGADKDLGTSPLQILPSTFSCGEVRRIGVVTGKSGKTYWLNLDDLGGYRNGANGLDDVLQVYQNENSVYAGAGVYPGEGGYIYINVIQYPTHVFKFSCEAGVPSFTKVADTPMNNAYILGVSHGTVTTLNGQPGTGLLWTTDVQGSQLKIFEAVPKDGFLNLIKSFSVPATTKFTRAVFGDGIMYQGTTQGYIYAFGSPVTTPLNCTSTNEFGTVDVGSESEPRTVTCTAVIGVTVDTVALDEAEEFTLSGVPALPLTLAPGETFTVGAVFKPTTVGLISADIVVDTTNDAEGYSLSTHIRLTGTGESANPLLSITPPTVTFQGVIAGQEGGTDESVILSNQGNSDLSITDVEFSTTSAAGPFTSWDRATSSLTVGKFTLTNVPATIPANTAVTVRIAFDSATSGSFGAYLKVSSNGGTKSFTIAGSAGPAPAALIEFQTPDGTGWVEYEADKPFSFGNVTENSSRALKFRVTNNAGEGAVRLSLTVSKPPFGIPGIIQAANLVDLAEGTVLGPGESATATMICTVPKAQWNTDPYTGVAPWTMNTNDPNFEKHLFSFECTAVAEQAPPLLPDGQGKYRYIGCYRENNPGRQLTNQLYGNPNNTNAMCIAACAEKGYVFCATQYHTECWGGPRIPVEKVDSRNCQFDCGGDLNQVCGGNGFGETEGLGAFLSVFADSVQWDGNTTTPAPSPDPAGPEVNPGVGQYVSQGCYTEPADERALTYLIPTEEKTVASCIEGCAASQYTYAGLEYGGECWCGNVLSAKSLPVDAAECSMACADNSTEYCGGSTRLNLYKLEGELPAPTSTAAVPTGTETSTAVPTATAPPTNERVGDWLLEGCYTEGDGVRALGARMYANDSMTLETCGGFCQGNKYFGTEYGRECWCGDEFGTGSVLAANQEDCSFPCGGDSTQLCGAGNRLSVYVYSPEGAVVDSETSTTVAATTTTFSTLAVPSNGTATTVATTTETPLAEEAGSRTAAAVEPTVESSTTTASFTPSNSTITSVSVTAEASSASSTPLATNLPTTLPSSSVLPDTTTSTSSATPTPTGPVISPGNENFTYYGCFSEPEIGRLLPTQILNRVNMTIDMCLNACYDTNYAGVEYGRECWCGDSLSLGGTDETRPAANVTGTECSFTCPGNSTQFCGAGVRMSLYILTEELERLEKSNSTLSLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHJ8</accession>
    <name>A0A1B7YHJ8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_03839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160060.1">
        <property type="nucleotide sequence ID" value="XM_018298814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHJ8"/>
    <dbReference type="GeneID" id="28862921"/>
    <dbReference type="KEGG" id="chig:CH63R_03839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03839"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="206"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="317" mass="32829" checksum="79970DF6D8EB518C" modified="2016-11-02" version="1">MAPTLESSKIAFIASNNYIIFIVIRAPLSPPRIHTKRGVIVPGGGNMAAAIIGGLVAKGIDKQNVIVSEPWDVNREKMAALGVRTTTSNAEAFAGADIAILAVKPQVAKAVCNELGAAVSSASGRDTVPVVVSIAAGITLEALRKWLALDDGRTPHVVRVMPNTPALVGEGASGLFAAPDVTDDEKKLTEALMASVSKATEWVDKEELIDVVTGLSGSGPAYFFAMVEHLISSAVGLGLSPEQAKRLAAQTCLGAGKMLVESPEAPGQLRKNVTSPNGTTHAALQSFEASGFQDIVDKAVKAATSRGEELGKTLGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI12</accession>
    <name>A0A1B7YI12_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160244.1">
        <property type="nucleotide sequence ID" value="XM_018298998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI12"/>
    <dbReference type="GeneID" id="28863105"/>
    <dbReference type="KEGG" id="chig:CH63R_04023"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04023"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="980" mass="110261" checksum="A9BD1C51CBD13EF5" modified="2016-11-02" version="1">MASQVGSIAQLLDATLDPSTHKKAEQALKIEQGKPQYSLSLLNIVASEPLPLKTRLAAALAFKNFIRSNWVDADGNYKLPGDEVQTIKSQLIGLMISCPPTIQTQLGDAISIIADSDFWERWQTLTQELVERFSPVDPKVNIGVLEVAHSIFVRWRPLFRTDELYTEINHVISTFAQPFVQLLVQTDEQITKNTQNKDVLKSWFEALSLMIKIFYDLSSHDMPPIFEEHLASISELLHKYLTYTNPILETDDDSEVSVIDTVKADICEALELYTLKYDEDFGKYTEPFITNAWNLLSSTGAETKYDLLVSKALHFLTAVAGTSQHSGVFADENVLGQVVEKVILPNVALRESDLELFEDEPIEYIRRDLEGSDTDSRRRSATDFLRRLQEKYEQLVTGVVYKYINHYLEQGKSDWKAKDTAVYLFISIAAKGSVTATQGVKTVNSLVNVVDFFEQHIASDLMASGGVEPISKVDAIKYLHTFRSQLTKEQWKLAFPPLIQNLASDNYVVYSYAAIAVERLLFLTDDSGKAMFPREDIQPFAKDLLDHLFKLIEKERTPAKLQENEFLMRCVMRILIVLKEGAAHLVEGVLTHLVAITNMIKQNPSNPRFYYYHFEALGALIRYCSSTHASLFNQRLWEPFNQILVEDVTGALRFGFSLCPVVNCMANNQIEFLQYIFQILAQLLESSPADAISENYKAFLSPLLEPALWDTKGNVPACTRLLSSIIPATSVYIVSDNKLEQILGIFQRLLAVKKYQLYAFDVLEAVVKSLEPGVVDQYFGTILSLIFTKLQGNPPDSLKLRFARFFHLVSARVEAGYGADYFMKHSEKIQEGIFAKVYPPFVLAETEKLARPVDRKLAVVSLTKTLCDSQAFAQKFAKGWANTCRILLALLVNPPVVSAGLGDELIAEADVDDIGFGLSYTALNTCKPIARDDYPEVTAVAPWVSAYISSANQRHNGAIVNFVNTRLTPEQQQALQQYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKG0</accession>
    <name>A0A1B7YKG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160949.1">
        <property type="nucleotide sequence ID" value="XM_018299703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKG0"/>
    <dbReference type="GeneID" id="28863810"/>
    <dbReference type="KEGG" id="chig:CH63R_04728"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04728"/>
    <dbReference type="OrthoDB" id="5423884at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="181" mass="20256" checksum="22BE319BEDF406BF" modified="2016-11-02" version="1">MPLIHRQTTAGGVVVVPATYGGYSNLSPGAIAGITLGAVAGFLLILWMVYTCLNFGRPVDTSSSSVYTSTASAISARPSKNRHRHHKHRSPRARVIATEEVRVRERGSLSRPPGPVIVEAEPPMMQERRASRPPPPRVVTDDEDDEVVVIEEHTPERRRRRHSSSRRHSHRGESRRRSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKN6</accession>
    <name>A0A1B7YKN6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_04927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161148.1">
        <property type="nucleotide sequence ID" value="XM_018299902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKN6"/>
    <dbReference type="GeneID" id="28864009"/>
    <dbReference type="KEGG" id="chig:CH63R_04927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04927"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="370" mass="40267" checksum="8653A5C26C6DA5E4" modified="2016-11-02" version="1">MSTRSSIYDPGDPSQPLLSQQRRRTSTFNFHLPSFSSHRRVSPLSVRRASLQEVHPHHDDVEPVLPAAPVAAHQETRLHKPQWALSDRPPNTWAQIRHTWREEFAEFWGTFMILLFGAGVECETRLHYRGPDIRENAGDFLQCRLAWAAGVSMAVWMSGGVSGGHCNPTVTVVLALFRGFPWRKVPGFLAAQVLGAALASLAVYLNYATSIAAYEGGAARSLVGEHATAGLFFTFPAAGLPYAGAFYTEFLASAALVAIVFALADKNNLAPPKGTQPFAMFLALLAIGSALGINTGYAMNGARDTGPRIALALVGYGSDVFTHDYYYWLWAPWVAAIAGGVAGACVYDAFIYTGRDSPFNMPRKEDERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLJ0</accession>
    <name>A0A1B7YLJ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161321.1">
        <property type="nucleotide sequence ID" value="XM_018300075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLJ0"/>
    <dbReference type="GeneID" id="28864182"/>
    <dbReference type="KEGG" id="chig:CH63R_05100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05100"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="92" mass="10363" checksum="158DEA8995E5323F" modified="2016-11-02" version="1">MSNVEGPAAPPPEGVVPDFQNPKDVLHTINLVSQILSIVMVSLFMMLRLYAKMFIAPPFHTEDLYRYGGGFHVYELSKADFMGFNKVIEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLQ1</accession>
    <name>A0A1B7YLQ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_05266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161487.1">
        <property type="nucleotide sequence ID" value="XM_018300241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLQ1"/>
    <dbReference type="GeneID" id="28864348"/>
    <dbReference type="KEGG" id="chig:CH63R_05266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05266"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="30980" checksum="94B04C97956C423E" modified="2016-11-02" version="1">MWLSNPSGVCIDGTVVFCTGGNGTICSAQVKALVYLGADACIVGRNVEKTLKMAEDISGARPHSRVLGIGNVDVRNSERLNAAVEECVAKLGAIDFVMQGLSTNAFKSVVDIDLLGSYNTVKATMPHLLASANRARSTGLPSGGRIIFISATFHYTGMPYQAHVASAKAGVDALSASVALEYGPRGVTSNVISPGGVEGTEGLQRLSSQASRESGQGSRQIPLGRYGSLREIADATVFLFSETGSYVTGHVLVVDGGAWRLAGLVGQSAGMTYPEAVLGEQALPEDIETGRRPKPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMI4</accession>
    <name>A0A1B7YMI4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161787.1">
        <property type="nucleotide sequence ID" value="XM_018296971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMI4"/>
    <dbReference type="GeneID" id="28861078"/>
    <dbReference type="KEGG" id="chig:CH63R_01996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01996"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="92" mass="10207" checksum="C53A01EA42D2F875" modified="2016-11-02" version="1">MFAGRFSSVDLPHTEAATSERVTSHIRSRAVDNTTKHPPSRPRQRIRLDASGSRRPSPASKIYRTIRGVVQNTESTAAADPREVLMCMTNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN98</accession>
    <name>A0A1B7YN98_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161996.1">
        <property type="nucleotide sequence ID" value="XM_018297180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN98"/>
    <dbReference type="GeneID" id="28861287"/>
    <dbReference type="KEGG" id="chig:CH63R_02205"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02205"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601805" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34801" checksum="B5E47B8984D9DF36" modified="2016-11-02" version="1">MRLFLLWQQLVLLAIAGQVQSHVSPRTFKFRGEKEGQIGGCNAADVEIILEEIEMAKKAAEFAAEQLTKYPFFQAFQEPKAFGKKELENAGKEVFTRIAAMLDGFHKDDGFTIECRNERCTENDADTVAIMSTKKDGTLDPILSLCQKFFETDSSTQKKLEQYKKAMGRNRNYVERWSGTINMQDLSHTRSVVIMHELTHTTYVATPIKELLGRKDEEDIFMTKDYYYDALDCYRMARGYHDVFTKILKSPERVRGARKAAENAESWALIASGMYMSKQLRIKQIPIQGIADWMWEDTRIGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNT2</accession>
    <name>A0A1B7YNT2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162217.1">
        <property type="nucleotide sequence ID" value="XM_018297401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNT2"/>
    <dbReference type="GeneID" id="28861508"/>
    <dbReference type="KEGG" id="chig:CH63R_02426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02426"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="132"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="301" mass="33729" checksum="8897C9D37B4C3C12" modified="2016-11-02" version="1">MTWPQEIDHMELSNGRSMTVCALHQLVTCGKCCVDFRFDNSDDEHTADEDLGVVKSAKHTPEAHVYGFRAVMPELAKPKAPNIVIEIPEKTKHFGTVFGQRKKKPMSLVELFPASSCVRVKPNVKRCMDRYDSLECLIYTDGACFDNGAADARGGSGIFFKPTYISDQSGSAAFKLEDRGPDGKAYRHMSNRAELRAIIAALRYRAWQSEGSRASSSPRIRPTSSTARRKAWHLSTGEPVKNRDLWEALLPDVEKLHDRGPHVRLWRILRKFNHIADRAAKGAAAILMTTDNFTDVFGDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNT5</accession>
    <name>A0A1B7YNT5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_02447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162238.1">
        <property type="nucleotide sequence ID" value="XM_018297422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNT5"/>
    <dbReference type="GeneID" id="28861529"/>
    <dbReference type="KEGG" id="chig:CH63R_02447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02447"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121158" checksum="492604533BB08E28" modified="2016-11-02" version="1">MSSSSLQQLQAQQLRAVSLDHSQHGLDSPGAQSHITTSSVSHHAFSSGTPNDGMRSNSAAQSLVDAPHFADDFSFPPPELHDQNAMMFLGEPDHPSDMFSTSHRPSVSSLGGRQDSITVMPAPFAGAMDQRRHSIIASDDGSQDSGHAEHNPLEDAGADEFGLATQIAGNGSDVGGKANKDDKTDHTPAWSELKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCLRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEERIIKIVPKNEHDSNAASLTRAVVKPAIPGTLPAAKAGPKKRVADEAFGQDLDHWAKAPAKTMLDTSNKPTSLQAQEAEDNKLFLEGLDALPSKEIQEHLAEVFFENIYGQAYHLLHKPSYMRKLRAGTLPPVLILSVCAVAARFSSHPKLITSSPNFLRGEEWASHARDICTRRYEWPNITILTCLLILGLHEFGTCHGGRSWALAGQAIRMAFALQLHKDLDHDPLNRNGPSQLSFIDREIRRRTMWACFLMDRFNSSGTERPTFVREETIEIPLPIKEKYFQLDMPAPTETLKGKVPHPVSVDEGQMADAKDNMGVAAHMIKTIALWGKIINYLNQGGKELDPHPIWSPDSEYTTLLQEAEKLLDELPECLQYSSENLALHDTEKMANQFLFLHIATQQNILFLNRVAVATPNSPAAQGVPRDFVAKAGDKTFAAANRISEILKDAESHMVTAPFVGYCAFSSGTIHILGIFSGNPAVEAASKRNLATNVKFLSKMKRYWGMFHYMTENLRDQYRTYADAARQGSATKEASTASPIFQYGDWFDRYPHGVSQSDFTDPATLKKKEKGDDAVLEQKPELHTVEEYFTNLSPPRGTESHPSRPNPSKRKAFAGKKLSTAGMRPDGGHAEPSSTTENIAVTAQEQLSARMQHQRGMQGSLGGQTSGPTSFNPLTASHPQGSNYHALSPISPITVSQFGHHHPDTSAFYTPDMLNMSLNQQNGILQPLDRQLVFGGYSMEQGNMSHFDGIDWDGMPSSAHGAHSLPGARSRSHRGGSLNGMGGPGHGHPDNNGGSSSMSGFGGQEASTAWFMPFNMEPPEIGQDIGMGLDGFGNMFGNGLHHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP71</accession>
    <name>A0A1B7YP71_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162259.1">
        <property type="nucleotide sequence ID" value="XM_018297443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP71"/>
    <dbReference type="GeneID" id="28861550"/>
    <dbReference type="KEGG" id="chig:CH63R_02468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02468"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="97" mass="10529" checksum="9A9030398D099F9A" modified="2016-11-02" version="1">MHPASDPRSFEGGSCRKRGLQGAGQEAQPAHGGVTNDVCPTQTIDHDATIQAAAERFTVLGEIQRGPAQSRMGYTRRYCLLGSGRFCLIYSLVDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPK3</accession>
    <name>A0A1B7YPK3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Hydroxyethylthiazole kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_02669</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162460.1">
        <property type="nucleotide sequence ID" value="XM_018297644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPK3"/>
    <dbReference type="GeneID" id="28861751"/>
    <dbReference type="KEGG" id="chig:CH63R_02669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02669"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="10"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR13943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="538" mass="55676" checksum="9E68F8981D99F9DB" modified="2016-11-02" version="1">MPQPTVDYSLYLVTDSTPAILGDRDLADVVAAAVRGGVTVVQYRDKTSDTGALVANARRLHAITRAAGVPLLINDRVDVALAVGCEGVHIGQDDMELTAARKILGPDAIIGVTASTIEEALKACEDGADYLGIGTVFATSTKENTKHIIGTAGLRAILSGLASAGHLPRVKTVCIGGIKPSNIQRVLYQSAPESPAPPLDGVALVSAIVAAPDPESESRSLLELVRTSTSYRHIVSSSSSSSASAIAAGTSLRDVAEILARVPAVIKAVASASPLSHNMTNLVVQNFAANVALAVGASPIMANYGEEAPDLARLGGSLVVNMGTVTPDGIANYLQALSAYNAAGRPVVFDPVGAGATSVRKAAVKTILAGGYLDLIKGNEGEVSTVYGQAALEQQKGVDSSSTLSHAQKATLVRDLARRERNVVLLTGVTDYVSDGDRTFAVDNGHELLGQITGTGCVLGTTVSAMLAAWEDDRLLAVLAGLLHFEIAAERAAVRGDVQGPGTFVPAFIDELARIRRLTVEGDLQWLSGAKVKAINVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQF9</accession>
    <name>A0A1B7YQF9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162709.1">
        <property type="nucleotide sequence ID" value="XM_018297893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQF9"/>
    <dbReference type="GeneID" id="28862000"/>
    <dbReference type="KEGG" id="chig:CH63R_02918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02918"/>
    <dbReference type="OrthoDB" id="21018at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="151"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="542" mass="61272" checksum="9B4B01C122B62473" modified="2016-11-02" version="1">MARTTAARTYGKASTKAKARRLFAEVPPSPPRKSDAAISVASDDDSVIKITEKLHGFEIQDEVYSSEDELSRDFNSIVVALPPQPAKSGSPKRELKKTPRATRSVATPKVKRTLSTPASKVEALETEIAEPVSPPHPGYRVLTWEEVCPPGDTIEKIAEASYAEVYRVRNERGTSIIKCIRLESPIKAQTKAQERSGLVDEEPHSEDDMRGELRISEWLADIPGFVIYKERYLVKGKAPKCLLETHQSFHRKMKRKDPDRLQFYPSPSRYLADTTFLVVELGDAGTALEDFELENSSQLWDIFFHVAIALARAEEMACFEHRDLHEGNLCIRKTKEPMTRDPKKAAPYFGYSGLDITILDYGLSRAEDLEVEESDPIALDLEKDLSIFTSTHAPQCKVYRQMRSLLLRGERGHLPPSAHKVPYAKGVGGEPLSWDVYVPYTNVLWLAYLYQYMVKGFKGEKKDVAEFKKVTKEMWKYLDPDAKAGTPAFGSSAEVVRFAFEAGWLDESHLMDIGGEEREDSIILSREETEELARRRSPRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSF2</accession>
    <name>A0A1B7YSF2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163401.1">
        <property type="nucleotide sequence ID" value="XM_018295039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSF2"/>
    <dbReference type="GeneID" id="28859146"/>
    <dbReference type="KEGG" id="chig:CH63R_00064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00064"/>
    <dbReference type="OrthoDB" id="4955540at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="140" mass="15900" checksum="F5B883842CE9492D" modified="2016-11-02" version="1">MSTVNIVKYYFHKANAPRDAERMRKMVLLAYQTAKDKKLYPKEVFIRSEVHLTTTINGVRQQDPKGLHITLCYKDQAQIDSGTHVACHGYVTDKESLQFIEATHAGEKPDSTKKNEKGDVVWPGAERLWAAPEIGYGHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVX8</accession>
    <name>A0A1B7YVX8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164545.1">
        <property type="nucleotide sequence ID" value="XM_018296183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVX8"/>
    <dbReference type="GeneID" id="28860290"/>
    <dbReference type="KEGG" id="chig:CH63R_01208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01208"/>
    <dbReference type="OrthoDB" id="4926491at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="345" mass="39073" checksum="EEE966AEA2DF23D6" modified="2016-11-02" version="1">MTTLPLNVKVAIRDHWTKEDSYLQQSLRTLQDVLGLEIDTAPDWHLLLTELEPTYTDKADAVAAVAATVEAWCRAATEILDDSKNEDWTETLLEKLKITWSRLRIFVDISREDDASTAWSEDRGGFVIYIPRRQRIMPVNLQPLFQAELKDCFADQKQLPPYSASPHAEDWAEVDMDARIGRLSVSAPAAHRRGPSVSSTATQPPADFMPRADALPRPDDLLLKPPYHLMIYSRGAHEIEIQCSHTATLKFLADYFKRWRRTNHQVASKVGHPKPPAVEVRVHQCTFGMGASIDRLVLATEHKYGGAFILTPTIILNLVEGVLGYKPVYSDATTWTYRRDIELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVY8</accession>
    <name>A0A1B7YVY8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_01294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164631.1">
        <property type="nucleotide sequence ID" value="XM_018296269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVY8"/>
    <dbReference type="GeneID" id="28860376"/>
    <dbReference type="KEGG" id="chig:CH63R_01294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01294"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="53993" checksum="B57D92A17E200DB1" modified="2016-11-02" version="1">MAAAAAHDTPEEPQSDGSKLKTFIGILKNEENVIGLAIKQNQTEAAFQQTSSWLTDCVFRSRFIGVADLAAVRFSLPSQLLEPTPNLEYWNYLDAPNAFVAIGTSDEPLDRMLEVCRFWFTKDLKYVKGKPCKPYNSCLGEFFRCNWETEDNAPKINTTALKGAGSGTASSSSSFKSAKGDKNASVASLSVPQHGTSTPDSKLLRISYLTEQTSHHPPVSAFHISCPEKGLSARGFDQITAKFTGTSVRVLPGEHNLGIFVTLEKRGGETYRLTHPAAHLGGILRGSLSVSVSEMAYITCPQTKLKTILHYVEAGWLGRSTNRVEGIIFKYDPENDDKVNIKDVPEADIVARLSGPWREKIEFTLGPKPVNSHPPEARYTIIDLNPLSVAPKVLPPKEKQLENESLTMWGGVTEAIHSKQFSRATQVKVELEERQRELARERERTGEVFKPVFFEQVTDQGGKPELTEKGREVLARAQKADWDMSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YXE5</accession>
    <name>A0A1B7YXE5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase GroES-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_01708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165045.1">
        <property type="nucleotide sequence ID" value="XM_018296683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YXE5"/>
    <dbReference type="GeneID" id="28860790"/>
    <dbReference type="KEGG" id="chig:CH63R_01708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01708"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08282">
        <property type="entry name" value="PFDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="385" mass="40904" checksum="65FF9CC67DED5FF5" modified="2016-11-02" version="1">MSSATMKAVNYQGPYKVKVSEVSVPKIQHPDDVIVKVTTAAICGSDLHMYEGRTAAEAGITFGHENMGIVEELGSGVTLLKKGDRVVMPFNVADGRCHNCEEGRTAFCTGVNPGFAGGAYGYVAMGPYPGGQAQYIRVPYADFNALKLPPGREFESDFILLADIFPTGWHGIELSGFRPGETVAVFGAGPVGLMAAYSAVLRGASRVYVVDRVAERLQSAEKIGCTPVDFTKGDAVEQIKKLNGGEVDRSVDAVGYQAVSAGGNAEQPNIVLENMIKVTRACGGLGIPGLYVPSDPGASDDASAKGMISLSFGKLFEKGLSIGTGQCNVKAYNRYLRDLIIAGKAKPSFVVSHEINIDDAEIAYEKFDKRIDGYTKVLIHPNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVH9</accession>
    <name>H1UVH9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_04451</name>
        <name evidence="5" type="ORF">CH63R_03501</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000285">
        <property type="protein sequence ID" value="CCF31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163292.1">
        <property type="nucleotide sequence ID" value="XM_018298476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVH9"/>
    <dbReference type="STRING" id="759273.H1UVH9"/>
    <dbReference type="GeneID" id="28862583"/>
    <dbReference type="KEGG" id="chig:CH63R_03501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03501"/>
    <dbReference type="eggNOG" id="ENOG502RCH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023111_1_0_1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497511" evidence="3">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="51058" checksum="A31DC99B881B74E3" modified="2012-03-21" version="1">MYYNTIALASLLAGTAVAETIHGVLVFSRHGDRTTKHYGAQSLTSLGAQQCFEVGSDYRSRYLESNSPHRILDISEDKYVPSQVYASAPDQAILLNTATSFLQGLYPPLVDLNAEIATSTLNNGSTSTSPLNGYQYVLLRGKNSNSPDTIWIKGDDGCPANAAAYKAFEASDEFRTRVAETKDFYAGFYDVLESVYDYRPENMTYENAYDIFDLVNVARIHNSTSLARNVTDEELLRLRALADSAEFGYNFNASQPDRSIHARTLTAGILAQLNQTVASEGKLKFSLLSGSYDTFLAFFGLADLIAVSDDFYGLPDYASTMAFELVSDDAAAFPADVDADLRVRFLFRNSTYGELTAFPLFGTGEETLSWPRFVGEMQERAISTVEEWCSACSSLVSFCAAYQDEAASSSSSSGGGGMSNAVAGVIGAAVTLGVVTIAGGIAFLLIKKRRSAPVVHIPVVSADKSSLRSGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVW9</accession>
    <name>H1UVW9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04567</name>
        <name evidence="3" type="ORF">CH63R_01935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
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            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="O'Connell R."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000613">
        <property type="protein sequence ID" value="CCF33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160861.1">
        <property type="nucleotide sequence ID" value="XM_018299615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYG8"/>
    <dbReference type="STRING" id="759273.H1UYG8"/>
    <dbReference type="GeneID" id="28863722"/>
    <dbReference type="KEGG" id="chig:CH63R_04640"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04640"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008227_1_0_1"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="670" mass="75115" checksum="4677B9C2DF2EB2E8" modified="2012-03-21" version="1">MSVVADQVRRLDAQLDRIPLGLSLSQEDGELSAEEHGIFNSATVDALSSPRIDELLHIARALSTTSSSLSLLPSQRIRALLHQSKLAEWDFQAEKSQGAGRGHYQSEIEWLLISKATVQTYGIILNTLLDQIIPLSDEMWYWDEVLSSYTYSSLYTVQTSPLRLWALTKDVYHESKHRIQNISHAPGDLVESTRTGLSQQWKQFYGIVRDSIRDSSITTLQRKVLSPVALSRGEARRKLAHLKRLRDMIASGLGVLVDEGLTFGGDDDDDDKSEAGVNSHDWKGVVERSVALMDMVLKEALVLEYGVSEFEDKVFAGVEEDPELSIHIEDANAVEKPSVLARRLLNILDTGLPNHVAAAQILVRNNGRPSRLIRYWLPATAALLSSTTILRLLANRRAEILGWIQDIGATARDFWFNWVVEPTRKIVGTIRHDSSSEIAIMSRDSLKADRESLERMVVDFALDKPHFVGDGASLTDVQIADLRTKVSEGDVTPVLRAFEKDLRTPFVGAIKGDLVRSLLIQVQKTKVDLEVAISGIDSLLKSQELVFGFVGLTPGVLVSIGIVQYLRGIFGARRGARHSHKAGKSIRVLRNIDRIFSEATPSQNNLLSYKDHGLLLCEVHVLRNLMQRALPRDRQREFREDLDDLANLKGIQVQIRALDRIRWAYARWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZ44</accession>
    <name>H1UZ44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_05471</name>
        <name evidence="12" type="ORF">CH63R_12238</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000687">
        <property type="protein sequence ID" value="CCF33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154053.1">
        <property type="nucleotide sequence ID" value="XM_018307212.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UZ44"/>
    <dbReference type="STRING" id="759273.H1UZ44"/>
    <dbReference type="GeneID" id="28871319"/>
    <dbReference type="KEGG" id="chig:CH63R_12238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12238"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="74"/>
            <end position="91"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
            <dbReference type="EMBL" id="CCF33245.1"/>
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        <source>
            <dbReference type="EMBL" id="OBR05535.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="598" mass="65093" checksum="FDD586157C7C5269" modified="2012-03-21" version="1">MAQDKTEVPVEEAGEHPAHTKIPYWRIVYDQAGITPEVAAHPYSGSGTEADPFLVQWIPHDPRNPMLFSKTTKWFITMMVSLTTLAVALLSSAYTGGIRQIIEEFGVSQEVATLGVSLFVLGFAIGPLLWAPLSELFGRQSLFFGTYAVLTAFNAGCAGADSATTLLVLRFFAGAFGSSPLANSGGVIADMFPAAERGLAMALFAAAPFLGPVLGPIIGGFLGAAAGWRWVMGFLAAFSGTFWLLGTALVPETYAPYLLRQRAAKLSKMTGKCYVSKIEHEQGKISLAESFKTALSRPWILLFREPIVLLLSLYMAIIYGTMYMLFAAFPIVYQQGRGWSQGIGGLAFLGIMVGMIFAIMYTIPENSRYQRVQEENGGFAPPETRLRSAMVGSVAVPVGLFWFAWTNNPSIHWIVSIAAGIPFGFGMVLLFLSTMNYLIDSYTIFAASVLAASSVIRSCFGAAFPLFTSYMYEDLGTNWASSIPAFLALACVPFPFLFYKYGPAIRARCKFAAESEAFMARLREGTVSEKEPENSPATEAVSGDAADLPTSSDDDSSVRRQATRRTMSIASTRRNSYDGNPYDIDRVHTRESFGVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZQ8</accession>
    <name>H1UZQ8_COLHI</name>
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        <submittedName>
            <fullName evidence="4">STAG domain-containing protein</fullName>
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        <name evidence="4" type="ORF">CH063_05648</name>
        <name evidence="5" type="ORF">CH63R_04455</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF33459.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018299430.1"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <begin position="1131"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="1158" mass="130086" checksum="0D6D0F0DAAF13AA3" modified="2012-03-21" version="1">MESATASPEAESSRRRSGRVVRAPEKFSPEPVTAPKRKRGPEHDEDDEGNEDDEPETDATMSDADESGDDRPRARPKKRSGASQGNRVKKPATKKPKTNGVAPSGHSASLPSRPKKTVRIAAADKQGEGLYSDVFASGLPLDEVADKWQTRYQANDALAIVELVNLVLQCSGCDLEITEDDVRDPDNCQARLTELQDLFQEEQVTEYPLISRAKNTKAFRDLLTGFFRSVVRSVHETDILYNDATLMENLVRWIASMSTSSLRPFRHTATTVILSLVHGLIDVANTLDSRITAIEQQINQAKRGKNKAKLAEMQRNLDEANNNRELCGHHIKDFFDTTFIHRYRDIDPRIRTECVEALGSWIIGQPTVFMQPEYLRYLGWMLSDVVSSTRQEVLRQLARIFRKDIQPLGHFIDRFRPRLIEIATKDAEVSVRVTAISVINVLRDAGMLEPDEVDSIGKLIFDSDSRIRKAVVNFFVSCVEDSIESKMEELGGQDALDELFGEIEDDDYDSPRSTWVNIKCLAENLAAFDAQVEGEQQDTNPHGLAVAADVTQASVPDTRISLASQALFEKVPYVKEWEVLAGFLLYDHTVSSKSRSKSNAASTEIAFKKAVGPEGSEEAILLEVLASAVKMSMLQTTEIEKNKKKSGRPEVTEAQEETALELATVIPQLLNKFGADPATATIVLRMEHFLDLEVFQALRQDSTKYEKLLDEISTQFNRHDDKRVVSEAAAALLHSRQYDELEELTDGRLAVLWENVINTLRSFDKTCELTLRGNLEEEHLIALSTVLMKISELARISDCAEVLETEGRAAESMSSTIDILVNIVRRGTFNEPSDVDDLEDEVTSFAIKGIQFYFMWKVRSFQKSIQSEIEIPDSAIDQLAVLRKKYDTGLIKTLSSRAIIDEIRIFATGALCDIHVLFGSLRNWTEESRGNANYRKLTRLAHELEPKLLPELISIYDGVERSFAKRTKKILNEPAEDEEPMDDDDSDEEEDEDEGLSQEEKLAIELKSEKALCELAAKFVLAIVQKVLDQTGPYAGKLRKRLLRNQGRLGKNFAEVVAYLDPSKVREHLYGKKQAAQRAKTSAKPAAAKPMRSEEIVVDDDDDDEEEDIFAEAEPEPEEGSKEDLRRRELLEEEEEEEPDVEEVIANNDADDDDVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0K9</accession>
    <name>H1V0K9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Importin beta-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_05889</name>
        <name evidence="11" type="ORF">CH63R_11923</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000885">
        <property type="protein sequence ID" value="CCF33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153738.1">
        <property type="nucleotide sequence ID" value="XM_018306897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0K9"/>
    <dbReference type="STRING" id="759273.H1V0K9"/>
    <dbReference type="GeneID" id="28871004"/>
    <dbReference type="KEGG" id="chig:CH63R_11923"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11923"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121684" checksum="970607D73E19A709" modified="2012-03-21" version="1">MSVLPPDVHAELSQLLQALQSPDNSVRTQAEDHLQNNWTANRPEVLLMGLAEQIQVASDASIRSFAAVIFRRIASKSRKNERGELVDMFLSLSQDQAAAIRQKLLESLGGDFQRAVRNKISDAVAEVARQYTENNDSWPELLGGLFQLSIAPDAEKRETAFRVFATTPGIIEKQHEDTVIQAFQKGFKDDSVQVRLAAMEAFAAFFRSLGKKVQPKYYPLIPDVLNILPPIKDSHDSEDLSSALVALIDMAETAPKMFKPLFHNLVQFSVSVIQDKELDNLCRQNALELMATFADYAPSVCRKDATYTNDMITQCLSLMTDLGEDDDDAAEWLASDDLDQEESDQNHVAGEQCMDRLANKLGGQTILAPTFNWLPRMMTSMAWRDRHAALMAISAISEGCRELMIGELSQVLDLVVPALKDPHPRVRWAGCNALGQMSTDFAPKMQTDYYDRVLTAIIPVLESPEARVKSHAAAALVNFCEEAEKSILEPYLDELLSHLFQLLQNEKRYVQEQALSTIATIADAAEAAFSKYYDTLMPLLVSVLQRENDKEFRLLRAKAMECATLIALAVGKERLGQDAMTLVQLLASIQQNITDPDDPQAQYLMHCWGRMCRVLGQEFLPFLPNVMPPLLELASAKADIQLLDDDEQVEQIQQEDGWELVPLKGKMIGIRTSTMEDKNMAIELLVVYAQVLEGSFAPYVAEIMEKIALPGLAFFFHDPVRFISAKLVPQLLSSYKKTYGSPSNELNGLWAATVDKLLEVLTAEPAIDTLAEMYQCFYESVEVVGKECLSTEHLSRFIDSVHSAIEDYKDRVAQRLEDKEGVAAEDAEDEAEDVLLAIEDDQTLLSDMNKAFHAIFKNHGAAFLPSWERLLPTYEGFLKSDDPTQRQWGLCIMDDVLEYCGLESQKYANLITQPLVDGCRDSSPAIRQAAAYGIGVAAHRGGIPWAQFLGGAMPFLFQVTQVPDARSEDNVYATENACAAIAKILHYNAGSVQDPNNIVAQWIETLPVTNDEEAAPYAYAYLAELIDKQHPAVVNQAGKVFVLTAQALEADTLQGQTASRVVGAIKALLSQAGVDPTPLLQQFSPESQRTITSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3I4</accession>
    <name>H1V3I4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS siderochrome iron transporter MirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_06706</name>
        <name evidence="13" type="ORF">CH63R_06062</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001272">
        <property type="protein sequence ID" value="CCF34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158887.1">
        <property type="nucleotide sequence ID" value="XM_018301037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3I4"/>
    <dbReference type="GeneID" id="28865144"/>
    <dbReference type="KEGG" id="chig:CH63R_06062"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06062"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_1_0_1"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MFS siderochrome iron transporter MirB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07690">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="131"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="507"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="579"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
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            <begin position="78"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10370.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3Y0</accession>
    <name>H1V3Y0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_01219</name>
        <name evidence="19" type="ORF">CH63R_12875</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
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        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
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            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02001334">
        <property type="protein sequence ID" value="CCF34932.1"/>
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        <property type="protein sequence ID" value="OBR03748.1"/>
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        <property type="nucleotide sequence ID" value="XM_018307849.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V3Y0"/>
    <dbReference type="STRING" id="759273.H1V3Y0"/>
    <dbReference type="GeneID" id="28871956"/>
    <dbReference type="KEGG" id="chig:CH63R_12875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12875"/>
    <dbReference type="eggNOG" id="KOG0450">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_004709_1_0_1"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
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    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK09404.1"/>
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        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="666"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000313" key="21">
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6E0</accession>
    <name>H1V6E0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_07499</name>
        <name evidence="13" type="ORF">CH63R_07154</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CACQ02001696">
        <property type="protein sequence ID" value="CCF35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156907.1">
        <property type="nucleotide sequence ID" value="XM_018302129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6E0"/>
    <dbReference type="STRING" id="759273.H1V6E0"/>
    <dbReference type="GeneID" id="28866236"/>
    <dbReference type="KEGG" id="chig:CH63R_07154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07154"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_1"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="215" mass="23679" checksum="D06E7385A6AB8787" modified="2012-03-21" version="1">MSSAFVQRPAPGFKATTVFPGGEFKDINLSDYLGQWVVLLFYPLDFTFVCPTEIIQYNDALPRFRALNTAVLGVSTDSHFSHLAWTEKPRKQGGLGADLELPLVADKSHKISRDYGVLIEDEGVALRGLFIIDPKGVLRQITVNDLPVGRNVEETIRLVEAFQFTDEHGEVCPAGWQNGSKGMKADPKGSLEYFAAQGETNGHANGNGQKRLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6P5</accession>
    <name>H1V6P5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_07588</name>
        <name evidence="10" type="ORF">CH63R_12464</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001744">
        <property type="protein sequence ID" value="CCF35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151855.1">
        <property type="nucleotide sequence ID" value="XM_018307438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6P5"/>
    <dbReference type="STRING" id="759273.H1V6P5"/>
    <dbReference type="GeneID" id="28871545"/>
    <dbReference type="KEGG" id="chig:CH63R_12464"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12464"/>
    <dbReference type="eggNOG" id="ENOG502SP0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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    </evidence>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018298657.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03682"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006926_2_0_1"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
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        <property type="entry name" value="Fungal_SecMet_Regulators"/>
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    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
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        <property type="entry name" value="Fungal_trans"/>
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            <begin position="206"/>
            <end position="281"/>
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            <begin position="536"/>
            <end position="548"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="621" mass="69130" checksum="9F358970A81615D0" modified="2012-03-21" version="1">MDGGHVDSGQWTKAGRNTASIESAPGPLFEQRLRSLFHENNGKDRDSPERDAPEHLENEDPRDLPFTPEWTSTNELIKGIPHQAFPKEAESNRLLNLFNSYMGVTQHFLDQRTFTDNMTLLFQSQASRARQMDTPWFTLYLLVMAMGKLMEEDPREVRGPPGAFWFAEAMRRLPPLHSISEYGIVGLEILCLATTYLQWNDRKNDSYFFVGTTVRLALTLGCNLPFSEQKCLPSERAHRMRVWWTVYMLDQRISAGLGRPASVDDRHLSFDLPGPSPGFDSPEPLNVNVQIARTTGEIMSSLYSRGALSQADLVRKMRNLLQSLHDTGRSIPANLAIDFSNKQFEVTRAGASLYLRLFQAIILCIRPILLQKVKDKVQKTEKQGSVSSAISQLCLLCNESALRIIRILMAMQRQEEIAPFAFFDLDAAFAAAFVLIMRGFAHKNDSQKPPPQELFQAIEFMEYLSQAGNNAAAQRLKDVRQFSAHVWVNVVAFDKDHDVQMGESGEEAGGVPHAGNTPGSVLPGQSDQQPSASQMPLTTPTPSSSVPSWEGEMFGGPDADTYGADTLFGLNLDENLEQAFGLEAAEGIYNSFNDPTLPLTGVDQLDWAELEKMMAPGGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9X0</accession>
    <name>H1V9X0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major myo-inositol transporter iolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_08455</name>
        <name evidence="12" type="ORF">CH63R_12462</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002267">
        <property type="protein sequence ID" value="CCF37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151853.1">
        <property type="nucleotide sequence ID" value="XM_018307436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9X0"/>
    <dbReference type="GeneID" id="28871543"/>
    <dbReference type="KEGG" id="chig:CH63R_12462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12462"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="189"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="329"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="39"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="530" mass="59976" checksum="91470D9E7AC7DA28" modified="2012-03-21" version="1">MPIVGAKEQHVDPTLSRIAQDDKKIWYQKPNLRFLYLILVPTGLGVEWTSGFDSSMMNSLQAVTSWFEYFGRPNASRLGLLNAMYSLGALMAIPFVPYVSQRVGRRRTILFGSYIMVLGAGLQAGARNVDMFLASRWILGFGIPFAIINASSLIGELSYAKERPIMTSLFNASWFVGAILAAGITYGTFQMSSTWAWRIPSLLQLVPSGCQIAFMPFCPESPRWLISKDRGDEAYAILHKYHSEGENGEEFVRLEYAQIMSTIQQEKEVASKFAWADVFRDAAMRRRFMLAAIMGFFTQWSGNGLLSFYMKKILNLVGITDNRTVQKVILSNTCWGFINAVPIALIAPRFPRRKMFLLCTIGTAAVYTVWTIASARFAIENSQRAAIPVLVFIFVYSPFYNIGWNALAYTYLVELFPFSQRAKGIAVEQLTVRFAVFFNTYVNPIALDSIGWKYYIVYCVWILVEIATVYMIFPETQGRTLEELSFMFEGKEVQDKVQKNTQKVLQVELEDIGRQESRPGSRDAGPDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAR7</accession>
    <name>H1VAR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01676</name>
        <name evidence="4" type="ORF">CH63R_13134</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002412">
        <property type="protein sequence ID" value="CCF37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152525.1">
        <property type="nucleotide sequence ID" value="XM_018308108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAR7"/>
    <dbReference type="STRING" id="759273.H1VAR7"/>
    <dbReference type="GeneID" id="28872215"/>
    <dbReference type="KEGG" id="chig:CH63R_13134"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13134"/>
    <dbReference type="eggNOG" id="ENOG502RSFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063296_2_0_1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="50"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="260" mass="29837" checksum="CC37557BA756AE20" modified="2012-03-21" version="1">MAHVIKWSGTPHTILKAHRRYVHSDRQKPQLYNPRQVYDKAPWPRGSHPSPHEILGASPGTPYSKKQFHRLVKLYHPDLYVQNGIEVMGVSRATRIERYRLVVEAHEILKDPHKRLLYEKYGLGWSLPTQRVRHTSASSHATGTYGTYDGRSSAEQARTGQQFPIFASNAVFAIVVIAMAMAGAVVQLKRARKAQWDFKDRDLVLQEAISRDLQGLADRLEGKPRDLRILEFLARRELRNWSSREALFAGLDQSENICRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VC05</accession>
    <name>H1VC05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09014</name>
        <name evidence="4" type="ORF">CH63R_02353</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R.J."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
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                <person name="Gearin G."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
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                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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                <person name="Sykes S."/>
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                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
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                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="Thon M.R."/>
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            <dbReference type="EMBL" id="OBR05219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="490" mass="52934" checksum="6FD988FAB9F84980" modified="2012-03-21" version="1">METTTAPGSHNDEAIATSPPIVPQRTPSQTSLHKTTHVHAHRQSFAENLRNAPGSPRAQRHPSFTQSAVQELLNHPPAASKHANPRFAGRDWRDVSVNELVAQDDFKWATLDTSVEEASMTLVKHSPSNVVLIRENDTAKIAVSTFDYNDLNTYLLIVVGLAKPEEEQVPLYDEIVNKARDGARIALRDIQPLCRKESLITLPFDETLERAIEVFGSGIHRVLVTSPTGDVIGILSQLKVIEFFWNEGINFPAIDRLYPVTLRDLGIGTQQIVAVNSDSSLGDALALMNAEGLTSVAVIDNGNNVVGNISTVDVKHLTNAADAPLLQSSCMHFISVILSERGVEHGRDSFPVFYVNPYSTLAHTVAKLVATQSHRMWVVESASPSPSAPATPLLAPTPSTVLVPGSGSAPQSPLPTQTHTAVPAAAMPGAHLSGRLTAVISLTDILNMFAKSSGLRPSDPGEQRARRRRSSSSSMRPSLDSSRASLDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDR6</accession>
    <name>H1VDR6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09475</name>
        <name evidence="3" type="ORF">CH63R_11074</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002944">
        <property type="protein sequence ID" value="CCF38369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152889.1">
        <property type="nucleotide sequence ID" value="XM_018306048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDR6"/>
    <dbReference type="STRING" id="759273.H1VDR6"/>
    <dbReference type="GeneID" id="28870155"/>
    <dbReference type="KEGG" id="chig:CH63R_11074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11074"/>
    <dbReference type="eggNOG" id="ENOG502S8NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_6_1_1"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07262">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="129" mass="14135" checksum="6F3D5CE5D9474251" modified="2012-03-21" version="1">MSIDHIGLFVPASIYKETVDWYLAALAPIGFKKFIEPNEYACGLGVQRSDFWIACHSADKANMPVHIGFKAENRKAVDDFHKAALAAGAKDNGAPGLRPQYHPNYYGAFVIDPSGNNVEVVCHTPEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEA1</accession>
    <name>H1VEA1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Concanavalin a-like lectins glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09614</name>
        <name evidence="3" type="ORF">CH63R_06933</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003034">
        <property type="protein sequence ID" value="CCF38554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159758.1">
        <property type="nucleotide sequence ID" value="XM_018301908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEA1"/>
    <dbReference type="GeneID" id="28866015"/>
    <dbReference type="KEGG" id="chig:CH63R_06933"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06933"/>
    <dbReference type="eggNOG" id="ENOG502RVMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078024_0_0_1"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28230" checksum="9E795CEB66F9AD0E" modified="2012-03-21" version="1">MGVSLSTAKWLAPLSFAVDFAAQNYGMLSSPNMKDVHDANLSFWSPQPFFIAGFFFPQQLFQLAWLWRLYKADVSVEPMDADIGTMIDFAPFYAIGNLCIATWMIFWNSSNLKTANIFVTINSLTQLYFIFKRLPPMNTKSINSVLTHVVAKTFAGIGVLDLLHNTSVAYFVHQQPSTTLKVLTGVGFGLLASASDWIFGGCLVYDLVALSVGQSVYGNADWSRLLGIFAGGAAAIVGARNLLKPPYISQSVAGYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKW6</accession>
    <name>H1VKW6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ph-response regulator protein palh rim21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_11320</name>
        <name evidence="9" type="ORF">CH63R_02388</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004352">
        <property type="protein sequence ID" value="CCF40869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162179.1">
        <property type="nucleotide sequence ID" value="XM_018297363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKW6"/>
    <dbReference type="STRING" id="759273.H1VKW6"/>
    <dbReference type="GeneID" id="28861470"/>
    <dbReference type="KEGG" id="chig:CH63R_02388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02388"/>
    <dbReference type="eggNOG" id="ENOG502QWMT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014594_1_0_1"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="472"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="733" mass="79611" checksum="3D5AF7A33327EFF3" modified="2012-03-21" version="1">MGNANPLPDLGAAGAAAAKFVTAAPIIIANNGVNYEETATGGAVQYKDFRDPFFSQSIFPVCYALAATTVTAYMLVIMLFITPRSFLDGGIVYLGRRGFTGGGTSNGISIGGRPWLQKVAAVTVAISLTIASADTFKVAEQQYQWAIQDAQKMQSEVMDGTELKVIRLISDTFLWLAQAQTLIRLFPRQREKVIIKWTAFALITLNLIFSALNSFQFPTSGSNGNARPRSFVNAIPALSYLFQLSLGLLYAAWVIYYSLMKKRYAFYHPLMKNMVLVSTLSLFAILVPVVFFVLDMAKPEFTGWGDYVRWVGAAAASVVVWEWVERIEALEREEKKDGILGREIFDGDEMLEVSASEFPWLRRRKNRHGGRDDGGQDGPQGGGAVAQGSPSGGRGNLWPGMTQIASRYRVNHAQANAEPHNAPNGQRSMGGLLRPPVWPSRPAPAVTPVSRTDTASAASTVYAVRYQMPSEATSRTPEVAPQDVHPPQRNPAAAISRSDSAFSRSKSVASDDEPAMAAPIPRPATHKAVEMDTEAQEDMAAKGRNGWRSLIANPLFRRTARDPPAEVMAHAESKSEARGGHDDAGRWDLRARLEDFAATQAEKIREKMRPTPETDSLPVTVIPAPPRQGAALAQLLEEERGQETPERVALTRTTSDASALSPQPAGALGRTASNFSHLSRGASQPPEAATLQLSRPPLWPGVRPQQQEYEPQSPSAPSHGRRLGDDSGPPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKZ3</accession>
    <name>H1VKZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02458</name>
        <name evidence="3" type="ORF">CH63R_08975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004368">
        <property type="protein sequence ID" value="CCF40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155972.1">
        <property type="nucleotide sequence ID" value="XM_018303949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKZ3"/>
    <dbReference type="STRING" id="759273.H1VKZ3"/>
    <dbReference type="GeneID" id="28868056"/>
    <dbReference type="KEGG" id="chig:CH63R_08975"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08975"/>
    <dbReference type="eggNOG" id="ENOG502RYPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006963_0_0_1"/>
    <dbReference type="OrthoDB" id="5427134at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="961" mass="106643" checksum="A5A432227DA9CB7A" modified="2012-03-21" version="1">MATTPLDPPLPGSSFFDIYNDGVAQRSPVPLPGGACNYVDLTPGASGAKCGCRRFWSRFAVGRMYTDNLGTDNSVWCMCSHHACFHDDGRAASEAPAPAFIPTPVAQVVGHENERPKMPREPLSPVQLPDMSFRMPAGFAPTMEFMNLDTAMILSPNKSKEPRPLRQDDSTPRPESTLQDTLSWGDFVQSQPGHTALPPIPAQCLMQSQPSSAASSSQARYLRPFAGKGLQTLSGVAASHMRSPQRDTFHDANTATEHDQSAKDDTGTAAPHSEHGEDTLRAPQFPCAVEKVDAVFAGPSRDTFRHLSDTVQGHEHRLERLENVSFSAAGHEECHEKHDATDLRVTDLEVRVEEVEKLMNDNGSTTVHRADRQTFDESTNSVLSVATSTTTARAGHSGEILGQIESLQAQISQLQSLLPTTARPWEIEVVFLPFPLKKIWQELLDFKSDGPSSLDEWTQMPNTMSSATLRAQSPFCAEWADPGHDYEWLMAKACSPTSIINKRLESRGLVRTISVKGSDARSVQAAMHAAFGTTFSELSDSSRSTSRQRSLDSKTSRFLGLQQPWVPLRKIHKDSRLRFLTPAEMITPAIWDVSFLNSVIMRSSEPRLFITQPDAYLQDLPAYESGWNWQRLREISRFYPDLHATVPEADAREDYWVWNDQLDETPSAQSSLSIRQAGQRVPASPSLHQIAMQSSMRSSSPMINRGQTPAKERRASKLPFIRTASLPPAVPATFSPSQQIKRRVSSFGQQRAAIHMRTSPPNISTAYKRRRTRSPSRPLNTPRWTISPSPMPGVIPSEERHPSTRGITPHYYATPYSNAPLTETRPRGSGGIVDGSPTEDDENLDPDYGSTNPYDDDEESNYSVEMVAQPVPVQERDSSYARQIQLPEDEPWPGIEDQDHISDGENIDPLFSPTAEDDVHSEVSSQPSEYPSTQRGWQVPGTDGEVGFRIHEDNDRMQGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VN45</accession>
    <name>H1VN45_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase I-specific transcription initiation factor rrn11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02642</name>
        <name evidence="3" type="ORF">CH63R_04532</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004835">
        <property type="protein sequence ID" value="CCF41649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160753.1">
        <property type="nucleotide sequence ID" value="XM_018299507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VN45"/>
    <dbReference type="STRING" id="759273.H1VN45"/>
    <dbReference type="GeneID" id="28863614"/>
    <dbReference type="KEGG" id="chig:CH63R_04532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04532"/>
    <dbReference type="eggNOG" id="ENOG502SC4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027162_0_1_1"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="49876" checksum="080E39422C90B05E" modified="2012-03-21" version="1">MSQSAPSRKRSASAMSLSDNQDTRFGSQLPSDSINPLSHTPSVLRQLRLAGLAETDQPPSRTQPRFPHRAWQDSKARSRGGPITAAKFVDSNDVDEEEEDEEMRLGNGDNDNEKPRRRKRDGETKAKYASEKSPFRPLVRAIYGFLDQGRVTDAKRAFGMLVRSHVHGKPVDIRRNNYWALGAEILMRQGGSSISARDGAPGAGEMYPASNVPRVREYFQDLIQRYPYNFKYRAAVSAVDFWPALLSYEVFQVHKQQSAHLQRLHRDAEEWEDDSWQEPSSLGGGGGDIDIHDMIVDDSDYKATGWQPDPRDRRLRQARDQIRLRTLDALREIAGRMDDLLEDRPFSHSHELLRLRGMVSLYIGDLLIPALAEAEGQMAEARIRRDAERNNARSSFQKMAEHGGRPDAFVQEMMVPADHDEGPILPVFSSLPIREYRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPZ8</accession>
    <name>H1VPZ8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_02794</name>
        <name evidence="12" type="ORF">CH63R_03744</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CACQ02005290">
        <property type="protein sequence ID" value="CCF42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159965.1">
        <property type="nucleotide sequence ID" value="XM_018298719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPZ8"/>
    <dbReference type="STRING" id="759273.H1VPZ8"/>
    <dbReference type="GeneID" id="28862826"/>
    <dbReference type="KEGG" id="chig:CH63R_03744"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03744"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_0_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="240"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="495"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="560" mass="60881" checksum="70CC7266D015B577" modified="2012-03-21" version="1">MSVAEFDKDPASGLLAQARRIAHDFDFPAEDVRRATLHFLRQLNEGLQQDGTSLCQIPSFVTNLPNGSEKGVCMAIDLGGTNLRVCSVNLKGDSTYSLTQSKAVIPRHLMTAPTYRDLFRFIALQTKAFLAEHHPSDLEAWSRVLKEGSVTDEERQKHCKSLGFTFSFTFDQHAINKGTLLYWTKSFDIADAVGRDPCAMLQEALDEQHLPLLVTALANDTVGTLAARAYTSPGRSGNVVGAIFGTGTNGAYMERVSRITKLHSRKEFRNSGPGAVMALNTEWGGFDSKLEVLPTTKYDRELDRDSVNPDDQHFEKRVSGMYLGEILRRILLDLIHSRPGLLELEVSETSLIHVPDSIDSSLLSSVVKDETPDLEHARHEIARVLGAAHVSTGDARAIKILSEAIGRRSARLSSVAIAGVALQSGALGPRVVEQPLAPSWSLGINILTPILYGVQSLWKLLASWLHVKIRVTVPKGVSASSFGSLEGLRAAVSDGEGEVVDIGVDGSLIEHFPNFELHIREALRGIPELGGRGDEMIRIGMARDGSGVGAALIAWAARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTH7</accession>
    <name>H1VTH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin synthase export chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03097</name>
        <name evidence="3" type="ORF">CH63R_12855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
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                <person name="Thon M."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="2" key="3">
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
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                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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                <person name="van Themaat E.V.L."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006991">
        <property type="protein sequence ID" value="CCF44568.1"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <location>
            <begin position="1"/>
            <end position="268"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR15064.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="268" mass="30034" checksum="CF3CE11E2DA09B51" modified="2012-03-21" version="1">MAEEREVIIIERYCPPGVKSIIAAGGSSFIGEVDDYTVFKYPLRAGDELTLNRLDTERQLLDVVGPHERIIQLKGFSETGLYLERAVNGSVAQHLESANPPPMQRRLSWCREAVEAVAWVHTKGVFHCDINPRNLLLDSDFHVKLADFQGQQLSPDGSGTVLLDGCSSESTRFFCPREDEFNGDVRTELFALGCTIYHIIMGHPVYPDIVDGEDGWHEKVQSRFRDKKFPSDLPICSEIAWKCWLGEYGSADELLLDMVAVEPACTEA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VX94</accession>
    <name>H1VX94_COLHI</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007235">
        <property type="protein sequence ID" value="CCF44856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152640.1">
        <property type="nucleotide sequence ID" value="XM_018308223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VX94"/>
    <dbReference type="GeneID" id="28872330"/>
    <dbReference type="KEGG" id="chig:CH63R_13249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13249"/>
    <dbReference type="eggNOG" id="ENOG502T7FM">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_589265_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 9"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <source>
            <dbReference type="EMBL" id="CCF44856.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="464" mass="53338" checksum="359DF160319D20B5" modified="2012-03-21" version="1">MAELMEAWWQAEIGSRVVQQAPLGVPNGSTGPPASNPSQPTSQGGPSASGVSSVFQELPNEIKDLVLMAASNPHTPNMRFVLLRQAVIHETDACPRVAPNPGCMCYRKRPNYITFWPLRHRHLVEYPEYAILCNSRNFKRPRDVIAATHRKVRGLVKRERRLDRFPQKLGDWSLTQVVYDDRIPALEVGDPYDCNLDDLVFVHIPTFRGMGPYLYESHFNSHPQVTWDPLLGQLTSIAINILNWEAMGDDDAIQTVYDRMQIGHTWELEAQEGTQNILNGRMPAKWPPLRPSGSVTTGGEPQPVWHPETPQRRVRRPANIPDPLLTNLSDFFQPQWVQNMRILTDVFTSLQKLYLVDLTGFNMLDDALREKMHRYLDTPAGDDECFWCHCSHPGKPRTWGGLEDVEFVEVRKCAAMEDLEISVTKFEEFRHYASHLWPRTDINKRPWTRPMPAFKLVVPYMRRR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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    <name>H1VYI1_COLHI</name>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
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    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">IMI 349063</strain>
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    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009812">
        <property type="protein sequence ID" value="CCF47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152351.1">
        <property type="nucleotide sequence ID" value="XM_018307934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4V1"/>
    <dbReference type="STRING" id="759273.H1W4V1"/>
    <dbReference type="GeneID" id="28872041"/>
    <dbReference type="KEGG" id="chig:CH63R_12960"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12960"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019326_1_0_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497799" description="Inactive metallocarboxypeptidase ECM14" evidence="16">
        <location>
            <begin position="22"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="192"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR03833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="540" mass="60396" checksum="CB6F1D03B11FB3B1" modified="2012-03-21" version="1">MRPQSVLSFAGIALLVPVTSAACFNAYPDPHHDTSCTAPNKADTFPLLKRLRNSVVEFVFGPHPAKATASASHALASLRDDHVNEVVLRFNLTTAEEETAFAAAAARTFLDIWTFNREYVDVRIPKRDIRSLLSLLPETLKTSYSTLIADLAAAVYDTYPVLDTPAQIHRFDDRRANLKLAHSGSDNYFFQDYQKLDTIVQWMRLTEAMFPAITEVINIGQSYEGRDILGLKVGMKTRAPGADKRKTVVVTGGMHAREWISTTTANYVAWSFITAFGREPMITKLLEHFDFVFIPVVNPDGVEYTWTTDRLWRKSRQQTGMSWCRGFDLDHAFGYEWGDFSENDPCSESYGGKEPWQATEATALAMWAKNASRETTEFIGLIDLHSYSQQVLFPFAYSCDVDPPNVENLEELAAGLAKAIRLSNGELYSVTSACEGAVAGRGFKPGVKRIETGGGSAIDWFYHELHAHYSYQIKLRDTGSYGFLLPKDNIIPVGEEIFSAMKYFGDYLLGNNGIEKSIGIAALAPEEPDRSLELRRLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5J9</accession>
    <name>H1W5J9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04273</name>
        <name evidence="6" type="ORF">CH63R_11648</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02010122">
        <property type="protein sequence ID" value="CCF47763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153463.1">
        <property type="nucleotide sequence ID" value="XM_018306622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5J9"/>
    <dbReference type="STRING" id="759273.H1W5J9"/>
    <dbReference type="GeneID" id="28870729"/>
    <dbReference type="KEGG" id="chig:CH63R_11648"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11648"/>
    <dbReference type="eggNOG" id="KOG0898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_1"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF47763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="154" mass="17692" checksum="D06802DCC84D9C8D" modified="2012-03-21" version="1">MADDPEYNAEEAAELKKRRAFRKFSYRGIDLDALLDLDSEQLRDVVHARARRRINRGLKRRPMGLIKKLRKAKQEAKPNEKPDLVKTHLRDMIVVPEMIGSVIGIYSGKEFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5S6</accession>
    <name>H1W5S6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04302</name>
        <name evidence="3" type="ORF">CH63R_04041</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02010211">
        <property type="protein sequence ID" value="CCF47840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160262.1">
        <property type="nucleotide sequence ID" value="XM_018299016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5S6"/>
    <dbReference type="STRING" id="759273.H1W5S6"/>
    <dbReference type="GeneID" id="28863123"/>
    <dbReference type="KEGG" id="chig:CH63R_04041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04041"/>
    <dbReference type="eggNOG" id="ENOG502SPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054097_0_0_1"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF47840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="400" mass="44286" checksum="FA5FA59E189510E2" modified="2012-03-21" version="1">MPPKKRSNANEAGEASGTAKKTKTTASGASAAANESRWSTKSKRWSAVSASRNADDDYKKAMEDIEYAYTYTCRCPLGTKGGDPDDEDEDEEDDYDDEEDDDDEGDEGEKQPKAKCDGGKTCLCMKPAAEHPDAPFVITNAGYRKLMNQQVHCQVRDPDNFDMYTYNDHYAYGILQVIQNLVLDYEEAKENWREQWVICEAIAPFIWFLSGGDFAMADDGELCRQTARLIGNLFLATLARLEREGALAPDSEVKDLGIVMAGMLKVASAFRGSSLFEGETRIKKSKKRPFPFVAETFDNYVAAYAKKHGITLRGVPKLKGLLEGVDDDVELPTVEQHGEDPWGWAAAFSEYKTGTTVGGDGLDITSWTSAERKKHAFNKKDPLGKKELDAIKKGLVMMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQI9</accession>
    <name>A0A1B7XQI9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150550.1">
        <property type="nucleotide sequence ID" value="XM_018309578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQI9"/>
    <dbReference type="GeneID" id="28873685"/>
    <dbReference type="KEGG" id="chig:CH63R_14604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14604"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase alpha subunit" evidence="1">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="336" mass="37431" checksum="7460109CF91F30CA" modified="2016-11-02" version="1">MSTPVAGSLRLVATPQVDLPRDYVCISPELAESTVFCAHEKDEGGGCTGKYVERSLEEGDYVMLVRPPSLTWLSTQPMRVKFWDRPCIGIKPEAFAGFHGDYDGDEAHCYPLSSPESLWEASNWVVPELEQFARGRRMMKELGLQPDTLKLEDHSHFVEYTILSSRQLAEGEDGLYFGEESRNPKVYVNGMSKRYNDTSTEDTFVLESVRGTMDILRQQLSQSSTDEMTRNAKISSSCFYRPEDGNMCNQTRQGNVVLARGVGCDPGSPVNRAVMMLCSKAQQSALDAHRVGSKANTGFDFIADIFKPNVSTHDPEGLATFCMFDSRAEKKARDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQQ3</accession>
    <name>A0A1B7XQQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150572.1">
        <property type="nucleotide sequence ID" value="XM_018309600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQQ3"/>
    <dbReference type="GeneID" id="28873707"/>
    <dbReference type="KEGG" id="chig:CH63R_14626"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14626"/>
    <dbReference type="OrthoDB" id="10640865at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="199" mass="22193" checksum="A6989205BB62B952" modified="2016-11-02" version="1">MRHTRATLGHEEHEHKHKRKRERDSDNDSHVSESSSEIHQRPTTDMTGADRRVIIVGCIDWSSLDSDAVDGSTTDFVSRDGPSSLQPSLLPQEQEKPGQDKDFEAEFAEIGERYRDATDRWQTAHSQIIDIEEELSEIDRLAEALRAAWSEASSRGTPIGGGGGSSTVERGLGDGGRRRLRRRRNIPIDPEILQGADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR32</accession>
    <name>A0A1B7XR32_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">24 kDa metalloproteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_14517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150734.1">
        <property type="nucleotide sequence ID" value="XM_018309491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR32"/>
    <dbReference type="GeneID" id="28873598"/>
    <dbReference type="KEGG" id="chig:CH63R_14517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14517"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600984" evidence="8">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="89"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR02216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="35554" checksum="51E769B277CA2A3D" modified="2016-11-02" version="1">MLLQRNAVLTLLASSALAYVVDLSPDSLSETTISRSFAKRQSLGRIVVVGGNIGKASEHYCSQSEVSKIDYDISWMRKLAASAFNFLLKDKSETTAAYIAWFGANNANRETANSIRRNVYNSIWDLGDETKAYVSDLDSGSDAVVIGCPSLREEPGCDGTMALAGNEGGYVKLCPLYFQSPSDYEELFRSWRMWRTRRLTGGETLLHEMTHLAGVVGSSWRATDVAYEEDKCLLLDDSDMIRNADNFMFFALEVKANPDNAAKQVDMDADEPKYKIARRLLADGSGSGGAGSSQVAPGMWVGNHFVYGQPGVYGYPQWPPPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRF1</accession>
    <name>A0A1B7XRF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150866.1">
        <property type="nucleotide sequence ID" value="XM_018308548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRF1"/>
    <dbReference type="GeneID" id="28872655"/>
    <dbReference type="KEGG" id="chig:CH63R_13574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13574"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="225" mass="23748" checksum="9F8BEDD0557D276E" modified="2016-11-02" version="1">MRAVPLSSSFSSSGPPSPNIPAGDVKVGRDNGNLLGAPRSTNLPSPITSPNPFRAFGDPNDSLQHFAGRCIIVSFGSAACAAQSTDDPSAASQPAPDNGYEYVPRQRLTRHRLHHLAIRADGIPASPARAMRWPGPIQQALSPAQRVYHNLFRLHLSLMPIDVERGGGVSGGPELQSGIGTETPVSKSVFPGFALLSSVSYSAATTHYRYDIVADALSSAPETRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRY9</accession>
    <name>A0A1B7XRY9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13761</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151053.1">
        <property type="nucleotide sequence ID" value="XM_018308735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRY9"/>
    <dbReference type="GeneID" id="28872842"/>
    <dbReference type="KEGG" id="chig:CH63R_13761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13761"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="68"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="383" mass="40957" checksum="4373AEF707DAA1B7" modified="2016-11-02" version="1">MPLVARLSRPLSSTLATRLPLASSRTPRLFHTSPHLARTLSPAPHFTMASSSSSVPQTMNGIRIPRTGGTDVLDHHTDLPVPVPAAGEVLVRNAYAGVNFIDTYFRTGLYPAPLPIVLGREGAGTVVSAHSTVDPDAFRPGDRVVYMGNFGSYAAYSAVPAAQLVRVPDALPTETAAAAFLQGLTAWTFVREAAEVKPDEWVLVHAAAGGVGLLLVQMLRAVGARVIAAASTDDKCALAERNGAGWVVNSREQDLVQEVKRITGGHGADVVFDGVGKATFDGDLELAARKGRLVIFGNASGAVPPFDILKLGQKNLKIMRPVVNNYTATRDELEKYSAELFDMITSGKLEIAVHKTYPLRDVKTAHADIESRKTTGKLLLKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSG0</accession>
    <name>A0A1B7XSG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13927</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151219.1">
        <property type="nucleotide sequence ID" value="XM_018308901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSG0"/>
    <dbReference type="GeneID" id="28873008"/>
    <dbReference type="KEGG" id="chig:CH63R_13927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13927"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="594" mass="66156" checksum="6D1559750701A250" modified="2016-11-02" version="1">MAALFKRATTRWRSRHATLLEPVTNPGSLADHLDDNGEGQSLIANMESSSDAQQHPPAEVRDGERQHIDSGMAKKIVRKIDRNIIPLLFITYMFNFMDKTILSSASVFGLRNDTVSCFSVLYRQHYRTYTTVRSSTSFWFMITDDGAQNLKGQNYSWVSSIFYFGYFAWTYPTSILIARLPVAKYMTANTFFWGAVVALTAACRNYGGLLTVRFLLGIAEATITPAFMFLTSTWYTRDEIPTRTGIWFAGNSVGGLVASFVAFGFGHISNDDKVGPWRWMYIVLGVLTFVWAFVLWIWLPDTISKARFLTADERRYAADRVVVAGTGSTEKTAWKWDQVKECFVDPKTWFIFGLEIITQIPNGGTQNFANLVIKSFGFTSLQSTLINIPYSLLSAGIIAGTGWLAGRYRKMNCILIAIIVLPCITGAAIIYSRDSVSSGVQLFAYFLLSPGPAAMPLAMSLVQANYRGVTKKMTMSALLFLAYCAGNIAGPQFFKAAEEPHYNTAFRTIMICYALVVVLALGLRFYLQWMNAKRTKEEGYEGSAGGAGAVGGGKVMQADGNANDVADMVDRVELRPEDYEDVTDWKTAGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTQ0</accession>
    <name>A0A1B7XTQ0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_14356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151648.1">
        <property type="nucleotide sequence ID" value="XM_018309330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTQ0"/>
    <dbReference type="GeneID" id="28873437"/>
    <dbReference type="KEGG" id="chig:CH63R_14356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14356"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="673" mass="77358" checksum="0A1223FA87EC17E2" modified="2016-11-02" version="1">MSSENPQHEFVVIQGIPVPPGGKPGLRKEFTKWATEKPEENIQVSLFIRALQLFYNEDYTKTLSYFQIAGIHGYPGTVAWDNSAEPTHKSRDDKQHFIYCTHNSLTFPTWHRPYMALFEQTIYQFMGKVIEQLHFSSEAEKNVWIEESTQWRLPYWDWALNTEVPDLFRPTTVKIRAPFGADGLQPEPEIVPNPLYRYELRVNGQVTKMGALPAPFTVDDVVFDGQRFPWSRCSGTSRWAIKSSEPDESQSLGINNYENISIAIREHGYYDPFLKLKDPRNIKDLENLDDPVGELRKHPVSDLVYRLLSNVKDWASFSSTITAQKEKPKDWEQWISLEYIHNNLHGFIGGFGGFNEGIGHMMNVPAAAFDPIFYMHHCNIDRLFAIWQVLHENSWFKDVKGPPATDSLTPFHHNQADYFDSNRARTWLNLGYQYDVLQRDDHETDVKYLERINAYVDKTYRSTGSVLLEDKGDLFQKNQDLAGDEMYDDYMINVSYDRYGYKNGAPYTIHFLLEELSTQETAIESDTSPPRPHRHVGSIFTFSSPVTSGEVHTAGHPRCGNCAQQLEEGVLSRASIPLTISLYKDATNQKVHGIRDLGPENVEPYLCDRLTWVAKSTDGTTIPWSELNRTKVYVFKGKAKHYPKTGRLSVYQDYKPLPRVTHGKDAGASHQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTQ2</accession>
    <name>A0A1B7XTQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151646.1">
        <property type="nucleotide sequence ID" value="XM_018309328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTQ2"/>
    <dbReference type="GeneID" id="28873435"/>
    <dbReference type="KEGG" id="chig:CH63R_14354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14354"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="93"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="365" mass="39815" checksum="6F7305D067EBF4D1" modified="2016-11-02" version="1">MNFDGRPYSSPSRVNSGALDFRGLCTREKSLGKAGQDVAYKCGKLQPNASGLLYLQPFSIPLLPASDLRSTPNANMTRAPVICITHGGGPMPIVGPMLGDKGHDNINATLSNRIPALLKLGTPDAPKAIVVVTPHWRPDRPTVTGTAEPPLYHDFEPSHPPQSWDISYKAPGSPEVAEKICELLRNAGLQPVKDMERGWDHGIFVPFLLINPKGDIPLVQLSILSTEDPVQHYRIGEALATLRDENVAIVGSGFASFHNVAIQRSLYFADPNSSEVQLWLGRVREWNKVLADSVLNRDPKERLRRLQGWRGFPYSLDMHPAGEAEHLMPLMVCAGAAANDEGAQFTDTFGGVEVASQYWGSTGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTX6</accession>
    <name>A0A1B7XTX6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151721.1">
        <property type="nucleotide sequence ID" value="XM_018307304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTX6"/>
    <dbReference type="GeneID" id="28871411"/>
    <dbReference type="KEGG" id="chig:CH63R_12330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12330"/>
    <dbReference type="OrthoDB" id="4839903at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="6">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="7">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="743" mass="83405" checksum="C74A46A71521F118" modified="2016-11-02" version="1">MTSLALTLRLLAPNESTAEVDVMLRKAAKVVKRMLNLRVMEIWNGQEGLAALFQYRQMGYRQRLMMTWGATWDYALQPSVIRAWEAVGIKQQGKNHLNDCVVVKERLNVGVVRCHGDAIHHLKLSSFFMRSVSLHQIRMENRILDGGKSKHPLLGHPHIWATQKCLITNLLLHPPPTSNYHIFFQPYANGLIFLGHLILGIMSQYTENEVNQALEAISNGQSVRKAAQQYGVPRSTLQHRLQGTQARAAAFSDLQRLTVSQEAKLAEWVRIQHALGLPPTHQQVKHFAERILHAIGDTQPIGRGWVQAFIRRNPSVKVKRSCPIDSRRVNGASTEVIRDWFKHLAIPEIISIKPANRYNMDETGILEGQGSNGLVLGMSEAKSIRKKQPGSRAWVSIIECISALGHRLHPLIIYKGKTVQQQWFPLDLSPYEGWQFTATENGWTTDATAVEWLQKVFIPQTVPQGKGDKEEARLLILDGHGSHTTTDFMWLCYINNIHLLFLPPHTSHVLQPLDQAVFSPLKAAYRKELGYLSLWNDSTIVGKRNFLGCYYKAALAGMTMQNIRSGWKWTGLWPVSMAKPLMSSLLLPTTPKPSASSDQVSKGQSRGKEAEGWASASSAVAWSTPRKMKDLSGQLKLFTELDNDAHTQRLLFMKVKKGFSEQAYELATAQHKLELLQAQVTNTAVRKRKAVQINPNTKFANIKDIQKAQVEAGDKEDITDESSEADLPSEAESCIVVASRCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU55</accession>
    <name>A0A1B7XU55_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NLP3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151817.1">
        <property type="nucleotide sequence ID" value="XM_018307400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU55"/>
    <dbReference type="GeneID" id="28871507"/>
    <dbReference type="KEGG" id="chig:CH63R_12426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12426"/>
    <dbReference type="OrthoDB" id="10377130at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601081" evidence="1">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="104" mass="11336" checksum="39DDE91AD4C9B4FD" modified="2016-11-02" version="1">MKLFALLTPLLLSIGGAAAHARYCLCAADGKGEDQATRRVCNRYIEGVLKMNDGGSVHLGKTSDGLNHDLCVGDTEDAFIWEDFERQCQDIGKVASLNCWTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU66</accession>
    <name>A0A1B7XU66_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151825.1">
        <property type="nucleotide sequence ID" value="XM_018307408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU66"/>
    <dbReference type="GeneID" id="28871515"/>
    <dbReference type="KEGG" id="chig:CH63R_12434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12434"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="403" mass="43511" checksum="C3AE9ADF0F7E641B" modified="2016-11-02" version="1">MNADLVDLVFLTRSQPSAPIFSSSVPSSSAIDYEKHAMPDPNNDAAAAAPETCPVDHKAREAWLQHARAANPAEAHPHPPHPVVSSADISPTQSQSWTQSLLSLTPFSSSSSSSSSPASNTTSTPPSASSAASTAEACPVDHKSREAWLAQARAASATANPHAQLAEQQTPSKPLDQAASQPSRSWTQSLKSYIPFTSPSSSATQDAPNPARPSTTKSGLDTEREVSTIPRTATSAYPGDSRPSNHEQETGADEATGNWIYPSQKMFFDAMKRKGHDTRAADMATVVPIHNAVNERAWKEIKEWEQPYLEGTACDGPKLHSFLGLSTNMSPKARINTLLGYTPPFDRHDWIVDRCGVQVEYVIDFYAGRPDAHGKPSFYLDVRPKLNSWEGVKMRALRGVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUB2</accession>
    <name>A0A1B7XUB2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151875.1">
        <property type="nucleotide sequence ID" value="XM_018307458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUB2"/>
    <dbReference type="ESTHER" id="colhi-h1vb58">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28871565"/>
    <dbReference type="KEGG" id="chig:CH63R_12484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12484"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601087" evidence="3">
        <location>
            <begin position="20"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="547"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="870" mass="91521" checksum="A2E75DEFD5441B67" modified="2016-11-02" version="1">MRNVLLLGVVLSILSGGLAASLPVVDLGYELYQATGFNEAEGYYNFSNIRYASPPVGELRFRAPVPPATNRSAVRNGLDFRICPQAQPLWMATSVEWLFPYLTKGVLPNVTGPAAVPTADGSSPALARDDRENEDCLFLDVLVPKRVFAKSGQKAPVLVEIHGGGYALGSKSESEPRGLLRRSTDFTEDGIVYVRMNYRLGAFGFLSGPTFSKDGTANAGLLDQRMALEWVQENIHLFGGDKDRVTVFGGSAGAGSIIHQVSAFGGEQHKRLFQRAIPQSPAWLPMPSALGQERSFNEFLEAANVSSISEARSLTSAQLIQANSLRVSLATPGTFGFGPTIDGQLVRDDPRALLDSGRFDKSIDVLFGHNPNEGLGFHSPVANSAEYLVGLRALLPHADDSVIRYLSDTLYPPRFNSSLYPDQMRRMGLTVTEAAFTCAASALGRAFAKADANAYGYVLETSFGLHGTDAPFIYFYPETSTVNETMASTLQDYMLSFVVDGVPDSDSGGLGRMMPYGQDGRVVRITADGILQGIDPAANARSFRFLGPDQGLRLQDLPIPTPGPGEALLRVKAAGLCHSDTHVLHGGGAAWMCALPVTLGHEVAGVIAALGDEPLSSSSSSSSSSQRFNVGDRVAVACVGHPIQTRDFREALGVGRDGGYAEFALAPLKHLVRIPAGVAFAQAAVATDSVATAYHAVVAEGKVSASHTVAVIGLGGLGLNGVAVSALRGARVFGVDVDTAKFERARALGAVDCAVGLDAFAAETLDVVLDFVGAQATAEAAVSMVRPGGCVVMVGLAAQSVRIATSALVTQNVSLRGSTGASIQELGEVLELVASGALTPYVEEIAFEDVPAGLEALGAGEVKGRLYIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVB2</accession>
    <name>A0A1B7XVB2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIB/MDM2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152235.1">
        <property type="nucleotide sequence ID" value="XM_018307818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVB2"/>
    <dbReference type="GeneID" id="28871925"/>
    <dbReference type="KEGG" id="chig:CH63R_12844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12844"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="529" mass="59364" checksum="8A12E1A70C406218" modified="2016-11-02" version="1">MPAMLAHRKFPSGLHMSQINGEAASLRRDIPRQAQDDTAKTRQRQYSLELTMPPKGPIMPPGHHPQAAMNQAAMAQHHPPGQALTSELAKRRSRKPTDKTLPDGVEDCIADADVAHRYRELRDFERRLDATMTRKRLDIVETVGRNAKVRYKTLRIWISNTVEDQAWQGSGLSVDSFDFTPSAEPSYKVKIEGRLLEDGQEDGSEEYTQNSDLVVGGGAAGSRRQSSLPTVKKQRFSHFFKALNVDFDRTRSRAASDQTVEWKKPATVNAAAGAEFDEFTFKRSGDETMNITINLHRQEDPERYLLSPELADIVDMPQASRQEAVLAVWEYIKMMGLQEDEEKRNFRCDELLKKIVNGSDVGIIPNLNDYIQPHLRPLPPVSLPYTVRVDEEFHKDPQPTIYDVRVAVDDPLKAKLVPFVTNPAYASALKEVVAMDEQLATLVSAVANSKAKHSFFTSMSQDPTNFVRNWMSSQKRDLEVIMGEATRGGGEDATGDDWRRGGKDSVWTSSNARESVSVMLAKQPTQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW05</accession>
    <name>A0A1B7XW05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152464.1">
        <property type="nucleotide sequence ID" value="XM_018308047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW05"/>
    <dbReference type="GeneID" id="28872154"/>
    <dbReference type="KEGG" id="chig:CH63R_13073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13073"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="465" mass="51824" checksum="583F1DBC85004FB8" modified="2016-11-02" version="1">MSGARPADGDATTTTTTMTTTTDEPEGPGRLPSRSWPPDAIVGPHPPESFLRFRLSDLGLLDGDLDDDGNTEHEELYRGQHPAGTQDDGGNDSRSDRPSIDATEDGATFNDAASLFSIDDASVAGGRPPSLWSLETSDYENGFQQRHGRTYHPIGAFCGIYMGGGMRWKRWPLADLPGTEEYILPNDTTEQFRLDIQHLLWLATWDGRLCMCPKNESASRVLDVGTGTGVWAMAYADEHPEAIVRNRPNLSLFCDGGAWLTYICVQVTGVDISPIQPQAVAPNCFFEIYNVEGNWPWRTPHDFIFIRHMNTAFADWSETIEKAFRSLEPGGYIELQDNTFPIMSHEGTLPPNSAIAKWSSMLMESTRILGRPCDEPSRFRRLLEDAGFEAVVEIKRVWPIGPWAAGRRHVMTGALCQDTSIAGLEPSTLRLFTTVFGWTVEETKDFCREVEAEIRGQRLHAYFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW30</accession>
    <name>A0A1B7XW30_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_13093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152484.1">
        <property type="nucleotide sequence ID" value="XM_018308067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW30"/>
    <dbReference type="GeneID" id="28872174"/>
    <dbReference type="KEGG" id="chig:CH63R_13093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13093"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR03966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="64388" checksum="69F5CDA83463C0C5" modified="2016-11-02" version="1">MASSGSAPNGGAHDHVLRPRPKKPQHSQLSRTQSNTSVGEMSALTPLSETGQTSGTTSGRSTPVPHDALPSVKSMSSARKQARAEQRRRIFPTIEFASRVSHFDPNSDYRDFHGFFNLFWIGLAIMAITTMLRNIKDTGSPMRVKIWTLFTIKIWHLAIADFLMVATTLVSLPLHRVWRAAPANGAFTWKNGGMAVQSIYQVLWLAFWIAVPFLLDWTWTAQVFLLIHTMVLLMKTHSWAFYNGHLSETEKRLRALDNPSTASKDPVYLYPTPDNPMGTVSSPKNRDFKAKADVASTSDEDSTSDEIDQLREDLAQELTSPMGNIAYPLNLTWTNYFDYLLCPTLCYELEYPRTARIDWQNLISKIIAVFGCISLLTVISEEFILPILTDASVRLNAVPPPPVSEALLILAESISWLLFPFMLTFLLVFLVIFEYALGAFAELTHFADRHFYSDWWNSTDWMEFSREWNIPVYSFLRRHVYSASRPYIGRLPATVITFLISAIGHEVVMACITKKLRGYGFICQMLQLPIVVLQRTKWVRGKKTLNNVCFWCSMIMGLSLICALYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW58</accession>
    <name>A0A1B7XW58_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152491.1">
        <property type="nucleotide sequence ID" value="XM_018308074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW58"/>
    <dbReference type="GeneID" id="28872181"/>
    <dbReference type="KEGG" id="chig:CH63R_13100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13100"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="3">
        <location>
            <begin position="648"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="953" mass="107889" checksum="68E0DF3456C268EA" modified="2016-11-02" version="1">MPEGTATVLTDMAELVDEKEKVRAFGQLQLQHLETVFKSKAVRQFIEGIEDWEDNLKTLKTFQNERQILIGIWGETGLGKSSLINALLGYRIVPTSQSSACTAAVCIFGYNNDTAGGNKFRAIITFKSWDTVKTELDALKKEQADLEDMRSLFENDPTSDFSGQYAEVERSIQSIMSWSGLSDAFIRKSSPEQILQNAKSLATDIFPNGKADNTGNHQEHIVAASERAFIRLLRQYVDSANKSSAPKYWPLVEKVKAFVDSPILRNGIKLVDLPGTSDAFGFRGEIAHSYQDRLDKVIVVTPATRAADNKAAADFILSENQTTQLDMDGMLKDESICVVVTKIDSMNCDTAETEFPTHDIVEKVDVLAEIEDALAEMEQHGNMVQDDGEDSKNVPLAGRKRANADQATCRAAKKQRLGSGNTDTNGKQERMDELQYQRDFIRSELKYLCIQERNKELKRKIKETLLDPSKRINVAEESVVAVSSVYPVSSEAFMELQKTPSIDGFPDVNSTGIPDLKAWLYRISLPYRQEWADADIHHIQVLIDAADGWTQANVTDLPRLSKSEVVSLQVRLDGLMKELGTAITSSVRRKLQQKLSHLEPLRKSSLTKVSLKRNLGKNGKETQMAMKNLRRFLEAWKVKNHWAGTRPSSKEDETHWSTYQACVKRHGGVFKRRARRTQPKAEIHWLGDVDLSFWRGHKDKWRTGFTQKFSTIKKTIHSSGLVAFKKWVESLHDDEGMPESFRELMKANTYKLDHLFDKYMTDVGEQINLFEKDARKERGIVQRYFSSGMRPGFEAAARIRGKQIKERQSQVVQKHVEADGVQMFRNARNALETQLAKLHRGTSKEVGQLWMAPKKGCGGRIRAEMLRVLKRSSISFLMPSAGTMMTDDAKAQIRTIVIRWRTTWHAVHVRLPRFVPVEEDIDSNAEEVDSENEEGDMSTEVQVKREPDEVGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWE0</accession>
    <name>A0A1B7XWE0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152568.1">
        <property type="nucleotide sequence ID" value="XM_018308151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWE0"/>
    <dbReference type="GeneID" id="28872258"/>
    <dbReference type="KEGG" id="chig:CH63R_13177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13177"/>
    <dbReference type="OrthoDB" id="4829372at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601135" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8727" checksum="3C37150289D572EA" modified="2016-11-02" version="1">MQFNFVTGVAILLAIQPVVARTCLLGAIQCTYNSGRRCAKWCPQQIYCECAGFKENYGDLVKAKCISEFTWMGRHNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWE7</accession>
    <name>A0A1B7XWE7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152593.1">
        <property type="nucleotide sequence ID" value="XM_018308176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWE7"/>
    <dbReference type="GeneID" id="28872283"/>
    <dbReference type="KEGG" id="chig:CH63R_13202"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13202"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="626" mass="69496" checksum="287A86CD8E25F79E" modified="2016-11-02" version="1">MSDHTQLDSSGPEDDSPSPFHGRRWADDETTRRISSFLAVAASVFETGTADLATLHGAAVEADEILRQCNPNRGNPPSDSSDPGPFTAFIPDIEARHARLRDLIAHLSRPHLRPLRLTSLPPEILAIVVAHCEGGANHQNDDEDDDDSNNNNPETVAAIRNLRVTNRALASLAAPHLIRTLDVSLTPSSLARLDAVSHHPTISTGVLRLRVSLASHPPRLAADLASFVRSAFRRLSREAKRDDRARRLAKPDADKHAARTREWIRNGAGSDFLVRAFTEFARRRDVHEAVRAARLGSRVADAVARMRNVRAVRVDDEAARPPWHEKYPARSEDDPLVDEEALLELVTLPMRWEAAAAWEAADKSDHPVEVLRDILVALGKREVPLTRLDVKLTPPARYDGLSCTEAEREDIQRAVRGLRSVDFEVKPSRDVRDEFDPPAWPPRGPAELAALGGFMSAALASPALEVANLDFGALRRENQDLWALDALLRSAPEGWPRLRRLTLHHPCLRASDLKTLVVRSERLAWLSIEAPHLSEGSWAEVLEMLHGRTDPRRRERGETPMKTPTGGEAEDMSFAQYDSVFSEPRGWTAQVEEGGEEAPMGEGRRLSAAMRYVLHLQAENPLYVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYG8</accession>
    <name>A0A1B7XYG8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_11484</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153299.1">
        <property type="nucleotide sequence ID" value="XM_018306458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYG8"/>
    <dbReference type="GeneID" id="28870565"/>
    <dbReference type="KEGG" id="chig:CH63R_11484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11484"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="298"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR04781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="399" mass="42804" checksum="B76CFC1475D2E1FC" modified="2016-11-02" version="1">MAGPVPTTSSLADIYTEDALPVQTKRWSSLLSQFEAEYGHPAAVVARSPGRVNIIGEHIDYSLYSVLPMAITADAILAFSVTDTPADSDTFTLRVANAQSDKYPARTFEVPIAGDVPIDAKVHEWSNYFKSGLRGALGLLRRKHGAAFRPKGMEILMDGNVPVGGGLSSSAAFVSASALAVMLANGEQTVDKTELTELAILRELIAVTKDTLTNPEGYTREEIAGVLGVSPAELEQIFMSKLSVRADRFKLRQRALHVFEEALRVLQFMKVLEQEAPAPASASGAAAADTTAYNQRLGAVLNATQDSCRDLYECSAPEIDELCRIARDNGSYGSRLTGAGWGGCTVHMVPADKVAAVTEAWEREYYSKRELTAEQREGAVVVSRPGSGSAAYLLKDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYL4</accession>
    <name>A0A1B7XYL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153339.1">
        <property type="nucleotide sequence ID" value="XM_018306498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYL4"/>
    <dbReference type="GeneID" id="28870605"/>
    <dbReference type="KEGG" id="chig:CH63R_11524"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11524"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601198" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="79" mass="8800" checksum="2BB5A65E8654CE6E" modified="2016-11-02" version="1">MRLCLRMAASRGHGLLVLGALGCGAFHNPPGEVAQCWREVLDEAEFSGGWWTEVWFAVYDRKNEGNFEVFDEVLGGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0G1</accession>
    <name>A0A1B7Y0G1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153999.1">
        <property type="nucleotide sequence ID" value="XM_018307158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0G1"/>
    <dbReference type="GeneID" id="28871265"/>
    <dbReference type="KEGG" id="chig:CH63R_12184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12184"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="227" mass="26049" checksum="64E7A2779928570F" modified="2016-11-02" version="1">MLSPFKKHKHIRSRASDYQTLPTTENQKTILSTPSRSSKISIFGIPFLSPKLGLTTLIFAALAISIIAIVHFGSAPPSHKLLHCGNSPTEARANGCVYSLVDVRWVPGQCYDKKMDDEFNSLPWHYFADKNGTREITQELAKQGDTEFWVTMEYHITHCEFTMRQLRRRYLEAARRSPQEVVASNTYMTEEEHFEHCVEYMNPRKIIEADLIVTFSKMDFGTCQVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Z5</accession>
    <name>A0A1B7Y2Z5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_10508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154906.1">
        <property type="nucleotide sequence ID" value="XM_018305482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Z5"/>
    <dbReference type="GeneID" id="28869589"/>
    <dbReference type="KEGG" id="chig:CH63R_10508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10508"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="565" mass="59300" checksum="67D679190908C700" modified="2016-11-02" version="1">MPTTDDDPSSTDARSGYQDHKNEKTAAAAAGGLSIKPDVSSLNTAEPAAAPDDLPGWKVLVIWSAIALGVLCTFLDEGIIATAIPRITDDFGSLTDVGWYGSAYQMTLCAFQLVFGRLYNQFSIKTVFLASLAVFELGSLVCAVSPSSTAFVAGRAVAGLGASGLQSGCMVLISATLPAKQLPMYVGAIGMVYGVAAVLGPVVGGVITNSRLTWRWCFYINLPIAVPPAVATLFLVQSPPPTDEQRRPWLEKIRGLDYLGMVLLLPGITSLLLALQFGGALFAWDDRRTIACFVVSGVLVVGFVVEQWWMGEKALVPPRLATMRVVAFGAVFGFCLDGAFFTLVYYVPLWFQAIQGATPEQSGVRYLALCLAFIFTIFLSGWGVTKTGYYQPFMLAGTVLLSIGAGLLSTLKVASGADHWIPFQVIAGLGIGASTQQAAVAVQSSLNEADVAIGVAVVLFFQCLGPTTAITVAQAVFASVLTSGIAAEVPGVDPQAVRASGATGLKDLVPAEQFGNLVQVYNHAITRTYLVAAALAAASLVGVVGVGLKKIESEGDTEKSDVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y395</accession>
    <name>A0A1B7Y395_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha beta hydrolase fold-3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155025.1">
        <property type="nucleotide sequence ID" value="XM_018305601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y395"/>
    <dbReference type="GeneID" id="28869708"/>
    <dbReference type="KEGG" id="chig:CH63R_10627"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10627"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="69"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="304" mass="33269" checksum="421E275986C2D865" modified="2016-11-02" version="1">MEAFLKSRETRPQLLQSLLAALPPLDPSLEEFCDVATLPDGYKIDLQIVRPRGVNEANGGRPLILLWPGGGFVVAGVEPTTRPAREFALEFGAVVVNATYRLSPENKFPRSVRDGYETAVWLSRNAGRFGADISKGWVVGGFSAGANIASVVSQRSGVEGLGITGTLLGIPFLLVKEIVPEKYAAEWVSREENATWSPTFTSAGIEDVQRGLEPDIRSPWFSPFNDVEAIAKSPRTYIQVGDRDPLRDDGLLYAKVLRDNGVEARVDNYLDWGHQGWSIFAPADAPAELGPNTMKGMRWLLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y398</accession>
    <name>A0A1B7Y398_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155017.1">
        <property type="nucleotide sequence ID" value="XM_018305593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y398"/>
    <dbReference type="GeneID" id="28869700"/>
    <dbReference type="KEGG" id="chig:CH63R_10619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10619"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="7937" checksum="35EFD85B3F207545" modified="2016-11-02" version="1">MAKPCHYGQTRVMGLGQLYPAHVGLPGNEIVDQAAKEAAGFSPIADACAAPPPEPEHLRTLIATTKTINRRASND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3G9</accession>
    <name>A0A1B7Y3G9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155095.1">
        <property type="nucleotide sequence ID" value="XM_018305671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3G9"/>
    <dbReference type="GeneID" id="28869778"/>
    <dbReference type="KEGG" id="chig:CH63R_10697"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10697"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="242"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="36874" checksum="6A974072391384DD" modified="2016-11-02" version="1">MALVEGWLPPTRENWETLTIVWQLSWPVFGSLQYFISWYGMGKTSVQSRLNIPGRLAWFLMEIPGVTTLLYIMNTLPAQLGIHDLPWQNKVLAGLFVRPMSPLSLLIRVLPQTHNARSVQLTMTTKTIHYAYRAVIFPIVQPSMSPIHLLVALSALSFQLMNGACLGSYLAAYGPTTKAQWDAALGFGGVAQFVAGIAIFYVGLAGNYFHDEELREIRRAEQRRQEKAVAASKGGNGGKGVHKHYRIPEAMLFRYMLYPHYFCEWVEWFGFWMASGWSVPGRAFLLNEIFVMFPRARSGRRWYVDQFGEEKIRKKWTIVPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3M8</accession>
    <name>A0A1B7Y3M8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_10756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155154.1">
        <property type="nucleotide sequence ID" value="XM_018305730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28869837"/>
    <dbReference type="KEGG" id="chig:CH63R_10756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10756"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="8">
        <location>
            <begin position="379"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1440" mass="160981" checksum="4D5694C3AFE936B5" modified="2016-11-02" version="1">MQDNGKDVKPDAHEDKDKDKREKPEHNGGHAHLVKSPKKRRKERPCTRCIKRNIGHLCHDEPRDPDSKKAKSSHAPSTVDDSETTQSDIARSSVDQSAAGSMGPPPPFDRKASAFGAAVLGQGNPLHLVSPGSVSGMPGNGSNMNQFAGFSDAWLTAQNHYHDMQSYHPNYMIAPEVTHEFNLLNDFLQTSLLDDGGILSDESQNSPAFSRTAGANDMLPTFGNHNNHNRANAASSSGNALSQQMLPPPNLEQGKSISRPGSVVQADKDKAREYYLQAADPSGNDTPEERMDRVLKAKYEAGLLKPFNYVKGYARLGTYLDSHIAPSSKQKILRTIDRFRPKFREKAQALTDMELLYVEMWFEKQLMEYDRVFASMAVPACCWRRTGEIFRGNNEMAELLHVPVEKLRDGKISLHEILTEESLVRYWEEFGTIAFDPAHDTLLTACTLKNPDDKATDPVIHCCFSFMIQRDNHKIMPPPNQPASPKNNPGDKLASFAILSQTLLKHLRSASDPPAIDSLLAELKPQLQAIANFTTISRAKSHRAGLDRKGTELWNLCTRLRREDVDGVPPARRKLLLQSRVFSFFMIAVARNSSPGAKPQIADVVHLTRLMLKAGKMCIDDESIRTSTNTLKLANAIFSKGAGYVADLGELQKTMLGPDDLIECKRLDSEYYILRTALAWKEDNLTVAEFMYDKGHLDPQSLDPSSAEKMTEVLFEMGKDLSKKGDFPMAARWLERAYNVINAQDLVHLSRDAIELRLAVCQALVHAFLGVDTQDSSQRALELVNYVESEIGDKPVVLLLRLELLQKTPAEVFDVEAYADILRRMVRAFNFSEAHFKLLVHHARKLHDKSPTQATSVVDGMLRGAMVSSGRDEWIERLVLLRIWMETTQRDSLTAVEGLAAVLAGLQDNLEKPFGASAAVGALTLIWKKIEVNYSQGHFDIADGWCQVALQPLFQNGGPANMSRVGRKLILCALGRNDTERARQALHDMSEAAQNEPMTRYLMYKVALRSADRELATECLERVGTAAGNEPDFLYACVLEAQQAGDRMCAMQAMKQLVNKFEFSETSPVHLPALLRCNIRLAVSVMESEKDAARQKTVVEEIIVLFEGGENVFSLQPGVVAYKVVAAKAIQRNPNDKDGNRLFTVKELDWFCQNAYNLGLKHSDNWDLERLVRLYNSCLAIAAHYPADIPSEAASDLAFRTMFCNFVAAAALMSLARVEDIVERQLQHYLVMRRHVKAYNEALEERAGGLDKRVKTDLTAKLATLMVFDFEAAMALKKYDALGYIIRTAKTCRDVNALKAMGDIALRGRLPSQGVIVNEIWELEKMKGDRLAKYIRCMFQAVLPLDAALGQRLMKQAIEVARDSAKDIRLAQGQHPFPPEELEWLVTVSFNQAVDAYNVRQDDECNKWADLAMNLAHYAGDDGELEALLQENRMKLKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6T4</accession>
    <name>A0A1B7Y6T4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_09271</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156268.1">
        <property type="nucleotide sequence ID" value="XM_018304245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6T4"/>
    <dbReference type="GeneID" id="28868352"/>
    <dbReference type="KEGG" id="chig:CH63R_09271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09271"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR07750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="183" mass="20820" checksum="23D2AC894B368279" modified="2016-11-02" version="1">MLKIWSMKKEQQKAENADTAGGKKKKVTAAQLRVQKDLSELSLGSTMKTDFPDPDDILHFTLTIEPDEGMYRTGRFTFTFDINQNFPHEPPKVRCKEKIYHPNIDLEGKVCLNILREDWKPVLNLNAVIVGLQFLFLEPNASDPLNKEAAEDLRLNREGFKRNVRTAMGGGTVKGQGYDRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6V7</accession>
    <name>A0A1B7Y6V7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156291.1">
        <property type="nucleotide sequence ID" value="XM_018304268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6V7"/>
    <dbReference type="GeneID" id="28868375"/>
    <dbReference type="KEGG" id="chig:CH63R_09294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09294"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="79" mass="9041" checksum="1AB5FA82765EA5F5" modified="2016-11-02" version="1">MCYQIVELYSACRCLYYQHAIDRCAGYGRPGHSIQKRTILVGYACHAHSEGHGQYASQHTYSDSGYHSSHSNKSSRHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7D5</accession>
    <name>A0A1B7Y7D5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156464.1">
        <property type="nucleotide sequence ID" value="XM_018304441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7D5"/>
    <dbReference type="GeneID" id="28868548"/>
    <dbReference type="KEGG" id="chig:CH63R_09467"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09467"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="663"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="806" mass="88211" checksum="85EA9EBF291F667F" modified="2016-11-02" version="1">MAELGTRIGPDPGSDPSPPHPVPVPDPNTTTEADADADIDIDTDTATLTSTSTFADTAQNNIHDADDARTRDADTMADFVQTPAPHPDEGPKMRCCCGRDDCAYLKHSCFVLETVEKDVHTAAKLGKALLARHEAYMADAERDRMSLNTRIEQLENEKEELQAENARTVEENRSLLDQLEMLNNTVQDSDIRIQTLEATLLSSHQAVRRLEGAAARAAEMERHIALLEQEQLRLQNTLITTESEARSAMQRWRKAERGISDLQEQLERMEREANEERERHVEVLGRMDRQREMEKELNAAAGRLKGAAAAKSLTTGKPAGSVVSHFVRDLLQDNANLQLGMAELREMLLNSNDEIQAMRDQLMCHQPVGEQDASATSTLRAEIGPDLGEMTQNISQELHIHHHYHVAEKTKPKKKRHSLNPGIFSPASISRSSTPPAVWRPGPSPIAPLASHSHKGSTSTVSVPPSNRWSVFSEQPSEFAPSSVPSSPQSNPRLSMFDRPMLETDIPMSPTTSLDPASPTWKLSHSKRPSEASTRSFSVPSKLLSVASPAPPAAPTLHVSQHISGTIEEEREDNFSEEVPGLVTPNDDHPETDTETETDTELSYSKDEELPQRRLHRAVSHESIMSLSGGLDIHTLKVRPSQLTLRPLGGADAVFTGVTARSTISRGSDKRSDALLRDSLAGRPFSRMVSTPPRSASPSSTYSRHSQNSAGLGRWVSWRPWTGGSAASASRAATPTVAPPTTPTPAKRSGKEKEKERDLLRAPGINQPGAIPGFQEYLAAHQRRGPPSKVSPDAVDVEALREGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7J9</accession>
    <name>A0A1B7Y7J9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_09501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156498.1">
        <property type="nucleotide sequence ID" value="XM_018304475.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28868582"/>
    <dbReference type="KEGG" id="chig:CH63R_09501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09501"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF32">
        <property type="entry name" value="DUF6606 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="15"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2072"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2414"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3199"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="3204"/>
            <end position="3235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="3242" mass="367836" checksum="8B429F68E6743629" modified="2016-11-02" version="1">MSAPLDSPATIHGALYNHLVLPAKLPQHRDLDQQIPLVEKTLCRRMAVAARIMSALPNNTDTCRETWETVRQTVVACQRLYQGGRIDKASLLRELQQLGPSGFIVLHIETQNAGLIIRRAQDPVFNDSVVFEAFEASAKNESVLAAKGALIWDFPGIAVAIPYTTFNDQDFQLSLANFIEQASLETVKDFAAYAFKAGTTVFEYRNTGDPSIISSLLMAILEENGRRFAPVLLRKRVRDDVCWNRAKKPWRRLPYYLVLRVAIQRYLTIALDHEKGRLEYKFFISVLLATFLDDSPTHHIGMEQTHFLKKKICRRLVKLDLDKDRCGDQDAVARYNHLFDCLGPKFDKSISRCSVLLEHALTQERLALVKHIPVLPRKACEQDLILSLRVSQVYIKNALQSFRFPKNKRYQLLPNEGPAEAAKDHLSQYARNYHKLIDKEMKLIASVPETCSEVSRQIFDYVQTALPMYEDNPEQKSLMLLTVMELWQKMDSIACESFPLLSEFHPVFHPQMLDVLLFSQFSDMARLASLQTFLSYRITRASTVQRNIFEDPSAGCFAERYYRESSDAPSLKFIHDSIVTLANQMRESKKAEWKRKTREYDELISRIDTSTCMYIVDEDNIHGRERHDPNCRRCSMMWNAQNMRISIFEEPLPVDPIVARSTVFELACPQEFAIYRDTTWWVLRHLATHFNDEGAKPRCFLRDYVQLKPFSKQSHGKVGLASTTKPFQTTHYISVPFPVEWDGGRDGVCRPNALKLGYFDERTSTWPGRTRFRPSFAHHTALVLPNNSPWKKVLETKACALDGPGPSSYEIMASQSSCPAGINNHEYLAMQTLMTGKKQRWIVLLAELGSTNLNFSSEVTMLVVSHLALQSGPRDEKGDVLRTIHNVFRDDHFCDRFVEQLCARLESLQANWRETYLMDVVITLLLRTHALTATNRDVSSKAFEAILRARKICVRWVEMLRAETFKASDVEMSRRCQQYALWAAILCKRTFVVHANQSVHLDDTALQAYIECCITLQDNLVVEVGALPQVLRHAVVSDMKLSYRLSSLVRKSIVSSPDTFRKAIMAVWPEADGRSRQISALRADQDAWVVCESHGHDGWNASIQVVQYNCCTGLLLVDSRPLGKLPKPPEHTAVLSELFGDQALLTRPSDMPGMDYTLTVRPKGYRIDVAYDSGSIVIRAIKGQQWLQYIQRNVFRSETSWDLPGPLLDGCLHWLDLRSGKVFISYAADIWNISHRNWTINTHQKTCSRPGSFGNDRIVDTYSPLFNRVARIFHGFETRPNLLVFQPPSKHLQVEIKRLQLLFYVNARQLLESPQLGSEIDLDQDVGTWYGLESKLVFRNPRDPQQRSILIPMGPLETKRERDNLVVRITPNGDYAKFVINKHLGRIESTPEQLLLYMKAQLHAYTSSIFPDPLTGRTGTEEALQWLSSGACQPWSPLRVGSTNVLARIAQLTPRHEYYPADLKVMKTDHWSENLTESVQHERFRPLVEQIMAISAELQTFALIDVGSGLLPPAGDVHLHDRARLRRQISERSFDNNAEQPASIDQEYLARDCVKPANTRHSQVLEIVHMLRTWPKNMATTSSLAQKLAQSNLIGGKADVFDKVSLNDRLSLDIAPSWGPLVRSCQEQQSAFALMFMLAPISYGSKADVELVRTLASFAILEELKAIELPPWAEYDNFQPNQIPKIDYLAKMITPFKTPAPKHDGDDIQMFASAKQLRRMREEKAAWEQRADADCKYLANFFLSQWPCVEPGISELSKSLFVDVEGATSAIRPEWKRLYQNMDLSMHLDAVQAVLNRHHSDSKYEPPYFIPSEEVFQQRLRGGEVPSLRFDLLKKSFDAIDTGTATRLQPASATAPAPAAAKAGPSSATLRHPAHIHQPIKLPYSQTRSSGTNVLAPSWMSSKTALVPSNAAAAELKQIVSELAKSKSMVRQKYGEDLQRSLEAFVSRKTPKDPSRNHSPAFVAREISLSMLTIERRFQTIQKGLELADEQISARRVRLLKAGQLWPAVTTITLLEQLRSTETSVLFGKCVREHLIDFGLAITSTQRDLRINHAVMRGDAGRYLDEMANQGHSNWNPSEHPDWLLLEIEANLMIRPDQVDVALATISPASGANSVLQMNMGQGKTSCIIPMVAASLANRQNLVRVVVPKALLLQTAELLQARLGGLLDRQVRHIPFSRRTPTQENVIRAYHKVHRTMMKQAGVMVCQPEHNLSFMLSGLQRLLDDRMPEAGPMINVQSWLRSRCRDILDESDYTLAVRTQLIYPSGSQMTVDGHPHRWQVAQGLLVLIDHHCHNLAYMFPHSIEVVRRPSGGFPLLFFLRSDVEEELVRRLTADILGGEKGILPMQNLEPAERLAVRDFLVNERPRDATLQRIRHLCHDRPSVRQTVYLLRGLLVNRILMMTLKKRWNVQYGLHPLRDPIAVPYHAKGVPSEQSEWGHPDVAILFTCLAFYYDGISVAQLTQSLEHLFKSDDPSSEYESWARTSQDFPESLRAWNSINVDDSLQLAEIWKALRYNVMAIDYFMNNFVFPQHAKQFKVKLQSNGWDIPLFSVGGDDQSAGSKGGDQNIGSGGCSSSPALTTGFSGTNDNRTMLPLTIKQEDLPGLSHTNAEVLTYLLHERSRECHKIVGFRGARASESDLLHELKRRDIKILIDAGAQILEMDNEALAKQWLIVDHSALAALFFDKGNKPMVIQRMGRKTPLLASPFADDLSKCLVYLDELEALSHSGWDKAKTTRFRLGTTQSVTFFAPPEVYQSIIDLQMKPLGAKIDSRDVISWLLDNTCDGIEQLQPLYYSQGIDFCRRMQAAIDNPDFIKDSYQRDNFIATVKQDEQHSLQQLYEPKRKIKGTGELRPGSDSKIRAFIKELNTRRKAFQDNGRAVHASALQEVEQEREVAFEVETVRQVKRPHHYPALSFPGLHPELESFAKTGRMPASAVNFIPATKSISKTAIGKKFKVSDKSSQNKLFVSGEFERTVKLSFDLTSDNFLRNVNWILWSPVTEIALVVVPEEAEALLPIMRNRFYTVATNLIVYSAPVTRKMLHLSDLKFYSIPALPSEWRAPAWLKIELGLYAGRLYFEWPEYDQLCDFLGIDQSSPMLEYLEESSDSDSADVQNHKEAKSTSIGLTARPLSFVQEWLAARRRGQDFVSTPMGFIAQGKVLQESHPFFRQAKTAKCDLLFAPTHNTANDQTNEDEYAVADYGVDDMGANEEADSDAHEDEIEYNDSEYDDSEYDDSDTDNLSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8C9</accession>
    <name>A0A1B7Y8C9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156804.1">
        <property type="nucleotide sequence ID" value="XM_018302026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8C9"/>
    <dbReference type="GeneID" id="28866133"/>
    <dbReference type="KEGG" id="chig:CH63R_07051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07051"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="2">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="217" mass="24126" checksum="D0C0F7E86F519BC8" modified="2016-11-02" version="1">MAATTQSSHTSTDSSSNPAESAASQHVWSFQPPRFEPIQYIPKRDEDQIRGFAVLEASAVAHEPLDNGGNHWTFYLTVAPNPLDLGDRRLVQFDSTPSGTPSGGGGSGSKANVVISLLEDREFSRAQCICRLKTRDSLTVGDFVDAITDHGREKYDFDDRGRGCKKWTADQMDLLLEVGIFVQEEDVANAKKDMMFQWDGFRRSGDHSEWAVGVYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8K2</accession>
    <name>A0A1B7Y8K2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156828.1">
        <property type="nucleotide sequence ID" value="XM_018302050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8K2"/>
    <dbReference type="GeneID" id="28866157"/>
    <dbReference type="KEGG" id="chig:CH63R_07075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07075"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="133" mass="14437" checksum="081F322FA5F53311" modified="2016-11-02" version="1">MSQVISVAEEPWINDILLGVYDIMLEKIRNRPVEVQYQAIITLRDAAATIASNIAKSNSGLVSMTKSSSEKEPADFAADVEASDLTTSVNDYYDTNKAPVNGMIPGSMVPMLGNTWTAYRRAASLRHTAGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8R6</accession>
    <name>A0A1B7Y8R6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arb2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156981.1">
        <property type="nucleotide sequence ID" value="XM_018302203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8R6"/>
    <dbReference type="GeneID" id="28866310"/>
    <dbReference type="KEGG" id="chig:CH63R_07228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07228"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="414" mass="45754" checksum="199A22B3ADE19AC6" modified="2016-11-02" version="1">MFRRRWSGLPQDPIYFVNEQDEIRNVDNPNYYFKYYLTKNGRVNDRQRFHFNEAIRDIVHDRLEKEGLNKILIPFGTEPTSPHVPLFTSANLATASRVVVFFGEPSQDLGILALRVANGPGGVGKGSMVSVVQEIGRQKSSASDPSPPGIVLANTGELWWWPEGKKALSPVQALAVPRKSMVHHGRAFHPKIHSVPRNESPEAHVRYVLDEALSVLVSPTARLDIVGIGLGADHATKALDSPDTWSLLGHRINTLSLLGSTTGIDELSHKPFMEFLPRRARAYITDEAPILTPLAQPGGNRNTASFTQHGCTVYSSGEAHYVERILITSGGPILDWVQQVALAGPDYRHPEVVAVDPRMPTEEEWAAGSFDDAWEKMPGFAKPSLGYAVSNEAHEPRRKIPDGDEEQTKGLITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9D6</accession>
    <name>A0A1B7Y9D6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157200.1">
        <property type="nucleotide sequence ID" value="XM_018302422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9D6"/>
    <dbReference type="GeneID" id="28866529"/>
    <dbReference type="KEGG" id="chig:CH63R_07447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07447"/>
    <dbReference type="OrthoDB" id="4747243at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601447" evidence="2">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="234" mass="25443" checksum="E325D02FE8EAA614" modified="2016-11-02" version="1">MKPSTLFCALGFVQLGMAIPVPATLSDLVTHVKGEARRLTKITRVSMHHTPPISTVKEPEEQKIEFRFDNSPVSPSEDVPPSLVLAAPRPLKTTYLQSLSKHPGSGKDRVVDVVGDGTPETIKPMTLEEGLAKLLPSKPRLGCWKHVQGPTPSMSVVDQHPDLIVLGAVLALVLVLLVLETVGTTFQGVRQHYDPRGEIRLEGDEKPCKSPSFRCDSCDSVPYEDDVGVQGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9F8</accession>
    <name>A0A1B7Y9F8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157148.1">
        <property type="nucleotide sequence ID" value="XM_018302370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9F8"/>
    <dbReference type="GeneID" id="28866477"/>
    <dbReference type="KEGG" id="chig:CH63R_07395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07395"/>
    <dbReference type="OrthoDB" id="5417386at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1100" mass="120512" checksum="060F9D0D6071476F" modified="2016-11-02" version="1">MGFPENNLNGRSEVMVVSSESGPPRLDLALTRGRRGTFDSFDSDLERSFYPRTARSSNDLFTQALGRADTADGDSEWGAVRARARGNSDREGMADLIDFLRTTSPPPEFPPQSVFDEDTAEPQEQSEKWGLLKKLRRPRTRARSESPARRPLTAGLPNSAVASKTASGNSHIAISIPLEYCHVGPDSDWALAIFNATPPLPPTPPVRSSDEENGNGFARPYASERSVTVLKTVSEKGSVSTLSTVNTTSTRRRAKGSVSIWPKINSTPMSPPRTPYTTPPGSMRGHPSTKTHHDRMPPPPPQYAELPADPVPAGRRPNGSLDKGFVFARDESSLSQATSRSPRKPRTKSASKRPENITLPSRRSSIKIVRPREDPLLDSQRSIAGLIGGDSRGQNAACDAPQLSPAALSESYSISPSIATTELSEPVVSSARSAKAYSMASIVRPDMPSATPRQSYIARPGSSDTAQTTLVAESVASRNPSTRTSASRQSRKERVKSLKQRDMEAIKAMAKQAQHDEDGEVTPRPRTCDTAISSLRLPSRDGTFGFKGHLPVHCIEAKLSATNLASMSKSHNKSPAGLANGTSVNISNWQATQEAETPGWETAREELTPGWETAQETPTINWEKTPLLADMTEDYQRISIAVGNGDARDSTMSSEPPRRWGSLHRTSWASSVPLLDRIGSFAPSDASDAHFAEMDGSCPHPRGTRMSRADSATLSLTDAHRLYLNRFSFFDSDDQVRVDSAEDDQSIAGSIAAFPKPGSGAGPRLSAIMPVAEVIPSLSVDERWSASTLNSPMTVIEVSHSPFAGNQTPRQGPTHVARPYTVGNMNPALLSVSRDQGHASGSSRREPALQAGGADETATLRPKSRPGEEDSVGFLNTSARELRNHYANLRSARVNDLAHEMLLNQERLEMRMHQQERNQMLFIERLERCMSELRGLPDHPFLGPRPVEWPLHDEEEDYIYESQRSSRDARHDVRVCRTGRPLGHSRSLQQHQHQQQPGSRRSSRRTVDDVAGGFDDVDGACAEQRSRRPSTSHSMPRRVRASRHQAVMTAPLTILGELDAMNPLIRELQLASRVSLEAAQAERTEASRGRHSDDYRYDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9N5</accession>
    <name>A0A1B7Y9N5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157076.1">
        <property type="nucleotide sequence ID" value="XM_018302298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9N5"/>
    <dbReference type="GeneID" id="28866405"/>
    <dbReference type="KEGG" id="chig:CH63R_07323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07323"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="81" mass="8904" checksum="153642307CD64C87" modified="2016-11-02" version="1">MAELYARPWLASPAAHAISDATGRDRSATDALMPRRNAVMPLRAAAASIARRWQSGANVSRPRQQATMPRSMDPDPDHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9W4</accession>
    <name>A0A1B7Y9W4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157360.1">
        <property type="nucleotide sequence ID" value="XM_018302582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9W4"/>
    <dbReference type="GeneID" id="28866689"/>
    <dbReference type="KEGG" id="chig:CH63R_07607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07607"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="78"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="461" mass="49821" checksum="ED7FBB7E28117168" modified="2016-11-02" version="1">MPASDRLDRVFAALLARRESKSQLRKLTLVPPGAADFSSNAYLSLSTHPDIQRRFLARIEAHLGSSSETPPPDGGRHDSVVSSTPLLGSGGSRLLDGNAPLAESLEGDVAAFHRGPAGLLFNSGFDANVGLFSCAPQPGDVIVYDELIHASVHDGMRLSRAAKKIAFAHNAVDPAEAQRWPRSLSEVLSALTDGDEGREVREGSRRVFVAVEGVYSMDGDVAPLKEVVECVERHLPRGNGLIIVDEAHSTGLLGERGRGLVCDLGLEDRVWARVHTFGKAMGCSGAIVLCSQITRSYLVNYARSLIYTTAMPFTSLAGIQTAYDFIANGHSEALLSHLWSLVAQTNDLLLTLLDRHRPERTLMHLAPGKPKSPIIPLFTSDPRGLAQHCQRRGFMIRPIVAPTVPVGSERVRICLHAGNTFDEVEGLVSAIEGWLVAQPIHQGELFDRALIARSAAPKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCM0</accession>
    <name>A0A1B7YCM0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_05504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158329.1">
        <property type="nucleotide sequence ID" value="XM_018300479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCM0"/>
    <dbReference type="GeneID" id="28864586"/>
    <dbReference type="KEGG" id="chig:CH63R_05504"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05504"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="49"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="460" mass="50423" checksum="76DE64C2B011768A" modified="2016-11-02" version="1">MEPEISPAEDDAPMSTSEALSVDPNETRQPLIIGVTLTALLLSTIATLLRVYVRALRLRSWGWDDSALLASYTLVLTVGILMLVNTEFGDGLHQATLPREKFFRSQEISIAAVAVYQATTGADIPKKAFPLIKAAFLLQYRRVFPLPAFQKLCDVFLLFIIAFGISQVVSICLACIPLRSLWDLTVPGRCITLLDWWLIGSSISLVTDVAIFVMPIPLLRTVPLPLKQKIVLMATFGLGFFTCAISVVRITTLKQASTSDDRTYDSVIAGIWSITELSCAIICVCVPTLRPLIGGQKTRVRPPTWLRPNIDQSSDTELHTQSGGSISSQKRQPRVISIPQKREEQDGPETVGSFSPRPRPRPRIDLSDVPGLLPPPAVSVAHYDGSPFDDSPGKDTMVPLARIDTEEGVEFLNIDGPEAELPTPLKPPPRRHTDRTPTPDDDGYFSAVVWDASGHPRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCV0</accession>
    <name>A0A1B7YCV0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158470.1">
        <property type="nucleotide sequence ID" value="XM_018300620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCV0"/>
    <dbReference type="GeneID" id="28864727"/>
    <dbReference type="KEGG" id="chig:CH63R_05645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05645"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="196" mass="21597" checksum="AD5219D753026235" modified="2016-11-02" version="1">MPITLQKAVAPASRFVPRSLFRSAQTPFIPFTLRAASTMVPKLKDPSLLKQDVCYVNGEWIKAKSGKTFDVTDPATGEKIASCPEFAKADTDAAIAAAATAFETFRTKTGRERSKLLRKWYDLLMENAEDLTTLITWENGKPVADAKGEVTYAANFFEWFSEEAPRIYGDTIPSSVPGNRVWTIKEPVGVCGLITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDQ1</accession>
    <name>A0A1B7YDQ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter transmembrane region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_05879</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158704.1">
        <property type="nucleotide sequence ID" value="XM_018300854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDQ1"/>
    <dbReference type="GeneID" id="28864961"/>
    <dbReference type="KEGG" id="chig:CH63R_05879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05879"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="173"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="527"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="826" mass="93080" checksum="194E91367B9D0796" modified="2016-11-02" version="1">MAEQSTLRQSAAEEAIAAFFEKYSTLIRTRLRNTSRTTRLLGTLAFAASIILSAAGGRRWWRQRREEKEQGRKLVRTNSWLHNKDGSRTIYVPYKDGTSKVVIQTTKPLTFEAHRRLFLNPPRVSGLGDGTVPSAQTKPGLNLAFLHQFLSLMSIMIPRWSSKEAGLLLSHSVFLMLRTYLSLVVARLDGEIVRDLVAGQGRAFLWGLVKWCGLGGFASYTNAMIKFLESKVSIAFRTRLTRYIHDLYLNNNLNYYKLSNLDGGVGQGADQFITQDLTLFCAAAANLYSSLGKPFVDLCVFNYQLFRSLGPLALTGLLSNYFLTASILRRLSPPFGKLKAVEGRKEGDFRSLHARLIANAEEIAFYGGADMEKQFLNKEFKSLKNWMEGIYMLKIRYNMLEDFILKYSWSAYGYLLSSLPVFLPAWGGLGGAAELAQNAPKGSRERGRMKEFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRVHADAYFLRGQQNELYSLSDVQGTIQKGFDGVRFENVPVVAPALWPTGGEELMESLSMVVRRGEHLLISGPNGVGKTAIARILAGLWPVYRGLVSRPKDIGQDGIMFLPQRPYLSIGTLRDQVIYPDGHHDMREKRKSEDDLKRILEDARLGYLPDREGGWDTRKEWKDVLSGGEKQRMGFARVLYHEPQFAILDEGTSAVSQDVEGLLYEVCKEKGITLITISTRASLKKYHTYNLILGGGERGDEWEFERIGTEREKMQVEKELQDLRERLEQVETWKARRQEIEEELSRVWVAGGDDLDPPSYAASESDSAKSKGKETASLQDLQGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGZ9</accession>
    <name>A0A1B7YGZ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159864.1">
        <property type="nucleotide sequence ID" value="XM_018298618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGZ9"/>
    <dbReference type="GeneID" id="28862725"/>
    <dbReference type="KEGG" id="chig:CH63R_03643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03643"/>
    <dbReference type="OrthoDB" id="4846306at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="328" mass="35190" checksum="93BA43B80B625659" modified="2016-11-02" version="1">MWPLWSSFKRLLARDYCEEVDGKAFWPGTGDNYYLGSPFLVSWFAGKASGYTNTTTALWNVWVQDVKYEEKTKDGGSAFRLNIYSRNITYNTEGDNWMWVPTDVCNQTVVSFNYEIPKDFEATGTYMVAAVREGAVTTSAATATSGPFTIIASSDPKASATEATNSQTTGTQSSPTGVLSVGTAVASSPANNDDRITPGAAAGIATGAVVIFLGLAGLLWFFWRRRRNNKRLAAAVMAREADGNSGYAKPELDGQAVVTEGRGTDDTGESKPAHLAELDSQQPWRFQSVAAEEKGNALVEETPMAELGAGSPLEGYGNAKAHSGVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH28</accession>
    <name>A0A1B7YH28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arca-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159894.1">
        <property type="nucleotide sequence ID" value="XM_018298648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH28"/>
    <dbReference type="GeneID" id="28862755"/>
    <dbReference type="KEGG" id="chig:CH63R_03673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03673"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7682" checksum="ADBDF6CDF27774D7" modified="2016-11-02" version="1">MAGGRFTDREEQEELYRILVKTDRRLGWPTRAIQAQLREAWGWGDSPSPPRMPIAGILNACVRAAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHM9</accession>
    <name>A0A1B7YHM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160022.1">
        <property type="nucleotide sequence ID" value="XM_018298776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHM9"/>
    <dbReference type="GeneID" id="28862883"/>
    <dbReference type="KEGG" id="chig:CH63R_03801"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03801"/>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601670" evidence="1">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="229" mass="24206" checksum="0FAA833EC0E2D5EC" modified="2016-11-02" version="1">MGWDGMARVTTLRCVACLSEFGWAGVYQAGASSSQSPIRFGVFISLIYSRPLSDFRASVEHTSPDSFHSTIKPSVIMAEWAKQTYNQQYEKWVPWLEDQYLKWFTKDNKASYATKGQTKVTGVEQVDTLQDGVNNLVGSQVGKGGLLQPVGDIASKEGVNRAERQGKDEDGGYVPTAVPGSASLNQAGSGVADGGKAVAGKTTEGLKGAGGYVGGLFGGGAGKSKPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHV4</accession>
    <name>A0A1B7YHV4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160170.1">
        <property type="nucleotide sequence ID" value="XM_018298924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHV4"/>
    <dbReference type="GeneID" id="28863031"/>
    <dbReference type="KEGG" id="chig:CH63R_03949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03949"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="237" mass="25643" checksum="F6006121477694CD" modified="2016-11-02" version="1">MAVDELVNPASGSVRTSHPVQGLPRVVRHITGHNAEGKSIFLSTDVGDHHRDLGDKSAISNIVYSTNQVPVELNGDVDVKYARENEPGITVKGGSVCRMIDFGPGAVSPMHRVNSIDYAIVLEGVFKMILDSGEERIMQRGDIAIQRATAHRWINVTGNGLLAARMLFVLLDVNDVHVAGDKVEGYLGELGKDYAGLPGHEKAENDKVEVQVSEKQPVVPVAVELNGTSGDYYDSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHZ8</accession>
    <name>A0A1B7YHZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160011.1">
        <property type="nucleotide sequence ID" value="XM_018298765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHZ8"/>
    <dbReference type="GeneID" id="28862872"/>
    <dbReference type="KEGG" id="chig:CH63R_03790"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03790"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="99" mass="10759" checksum="505A6A3EE10D9BBB" modified="2016-11-02" version="1">MTSIQSSTTGTSSENVASDSSKDTFEIHSNLVSSADLIQVLESCLQVDAFTVEMRHSVYIIRVNDSCTKEEKASLEKMASENVSLKLIIPLKNLTFSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ67</accession>
    <name>A0A1B7YJ67_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartokinase</fullName>
            <ecNumber evidence="9">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_04413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160634.1">
        <property type="nucleotide sequence ID" value="XM_018299388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ67"/>
    <dbReference type="GeneID" id="28863495"/>
    <dbReference type="KEGG" id="chig:CH63R_04413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04413"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="57161" checksum="76D45C390B94308F" modified="2016-11-02" version="1">MSSQSIGNTSSNGWVVQKFGGTSVGKFPDKVGPPRTGKLSLRKLTEVIRMADRYGYCPNKVVVVCSARSTGKKVEGTTSRLLGVFNKLKGIAAPTSAEEAQNELMNQANGLIDDICKDHVSAVKTFLTNPELQASLEQEIRDECQELVEYIVAARRFNLEVNSRSKDRCISFGEKLSCRFMAALLKDLGVAAEYVDLSDAFHYDATGRLDQSFYQEAAAVLRKKITACEDRVPVVTGFFGNVPGSLIDGDIGRGYTDLCAALCAVGLKADELQVWKEVDGIFTADPTKVPTARLLHSITPSEAAELTFYGSEVIHHLTMDQVIHASPPIPIRIKNVKNPRGVGTIVVPDPVLTAGHQIQRSQPSDPSLIQKPKRPTAVTIKDKISVINVHSNKRSISHGFFAKVFSILDSNQISVDLISTSEVHVSMAIHAGNSEGSSFDKARLELEDCGDVSVLHDMAILSLVGAEMKNMIGIAGRMFSTLGEHNVNLEMISQGASEINISCVIDARDATRAMNILHTNLFTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKH9</accession>
    <name>A0A1B7YKH9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161053.1">
        <property type="nucleotide sequence ID" value="XM_018299807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKH9"/>
    <dbReference type="ESTHER" id="colhi-h1uxu8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28863914"/>
    <dbReference type="KEGG" id="chig:CH63R_04832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04832"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447779" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="600" mass="65149" checksum="672964839EC80D32" modified="2016-11-02" version="1">MTSSIWVGLTALLAASNSALAVAKPVTSRSWLKPKVEIDYANITGRVSGNIKEFLGIPFASAGRFEHPQLFTQQLGDFDGSSYGPICPQKTTASILTKNSSSSLVLGETGTAIGPVVGALADTVFNTLGQTRSEDCLLINVQTPVNASRGDKLPVVIWIHGGGFEVGSPFTDTSETDVIRGAALNYNVGGLVRTSVNLGQPIIGVSANYRLNAFGFSASREMEEAGLLNLGLEDQRVAMKWVQEHIADFGGDPDRVVIMGESAGSWSVVAHLLWDEGEGATDLFRGAMALSGGPVMVESAERAQPFFDNMVERAGCAEAMDKIACLKVADFDDIMASVNEEGMRPRSLASTWTIRPDGKHLKDSPHRLAAAGKMASVPLITGDMRDEGTLFSLLAQLETLSDEDFASYFQTTWWPKATDADMAALMELYPSDVRQGSPFDTGVLNAVTPNFKRLAAVVGDFSFQAQRRNLLAHYNTSEQAVWNYITDVSVPAAGLLPDLGVLTHLPVLGSFHAFDVWFYMFAGLPYGLSKNTQAYQATAISFIRTLDPNNHGLDLAKWPRYTEDGLETYNFKESGPKVVRDDWRVEAMQFFNDHPDSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL35</accession>
    <name>A0A1B7YL35_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_04914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161135.1">
        <property type="nucleotide sequence ID" value="XM_018299889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL35"/>
    <dbReference type="GeneID" id="28863996"/>
    <dbReference type="KEGG" id="chig:CH63R_04914"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04914"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447788" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="284"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="49975" checksum="BB015E5C43A09F58" modified="2016-11-02" version="1">MKLSATSALVSWASLSACLIHERQTSKPLVDSGSFQEQITKENLEANLVRLSDIATANGGNRAFGYPGYDASVDFIWSRISAVQGAKVWKQDFPAVFSSELRAKLTVDDEELAAYGLSGSPFTPGAGITGELAAGPEGVAACEAASYADLDVAGKIVLVREALCPGYRDGYHAGVMKPAAAAGAEAVIVINDFYLNLTAGTLGPADDGTYVPTGFVNQYVGDPLKARLDAGETLTATFWEDEFVDSRVTQNVFAETEGGDENNVIVVGSPVPSDLEDLLNKAQLGAHLDSVAWGPGINDNGSGTSLLLELFLALSKYRTNNKIRFAWWGAEERGLVGSRYHVNNLSAAEAASILAYLNFDMVSRGYYGVFDGDGASYGVAAPPGSDVIQDLFAAEFAAKGVNVTAARFTNGSDYASFWQVLNKPIGGLHTGTGSAQDPCYHQQCDGINNPDLNQLTVNAKASSEHHLCGRGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNJ2</accession>
    <name>A0A1B7YNJ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162021.1">
        <property type="nucleotide sequence ID" value="XM_018297205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNJ2"/>
    <dbReference type="GeneID" id="28861312"/>
    <dbReference type="KEGG" id="chig:CH63R_02230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02230"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="74" mass="7817" checksum="5CE9A5A5503BCA94" modified="2016-11-02" version="1">MTLEGEPRFRRKMRYFGLATPPGEQDDEPARVGQGTPGGVAVLRPGSSVHRFGVLGSDAADDPTTTIPEHVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNY9</accession>
    <name>A0A1B7YNY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162181.1">
        <property type="nucleotide sequence ID" value="XM_018297365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNY9"/>
    <dbReference type="GeneID" id="28861472"/>
    <dbReference type="KEGG" id="chig:CH63R_02390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02390"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="96" mass="10619" checksum="7CC06ED350B2B579" modified="2016-11-02" version="1">MKLRRVAALFRSSQSSQTWNGFQHVAGPVLCCPLAAKSSRYLFGSTEIWAGCNSWRLTGSQKTRSDLCRPFNTITKTLLGALNRLGRPFGITRGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP07</accession>
    <name>A0A1B7YP07_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162303.1">
        <property type="nucleotide sequence ID" value="XM_018297487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP07"/>
    <dbReference type="GeneID" id="28861594"/>
    <dbReference type="KEGG" id="chig:CH63R_02512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02512"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="182" mass="18871" checksum="D4CDA1A6C6E35270" modified="2016-11-02" version="1">MLNLITVGVWAIQGIMAIVVLGLSVDLVKGQMIGDAPTTTKYGTFTGGFGLAVAIMGFASAFIDAIPALAIMAADALSGLLLLGGGIAFVIGLRGVTCDLPEDDIGLKTLSGNSLINGGTVKIGKVNTLHEDLTFSRLLDNCRKATADQAMHFVTFGFAVATIFLVFLVWKNGRGSRGGSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPG3</accession>
    <name>A0A1B7YPG3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_02673</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162464.1">
        <property type="nucleotide sequence ID" value="XM_018297648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861755"/>
    <dbReference type="KEGG" id="chig:CH63R_02673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02673"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1519"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1801" mass="199422" checksum="C5F8C56EC0E32531" modified="2016-11-02" version="1">MASSLAAQLAQIAANSKASLDIKAQKAAHSKSLIFEPRVAATQSYQTLFTICSEGFEELCELDGRFKPFSKTLFSEQSMSEDRTQMTTAENAELDKKVESFLRLVGSRLRLMPSIRALEWLVRRFRIHENNTKSLITTFLPYHSIPAFVTLLSILPPKIPHEYRFLSPYIKSLTSPPRSVLVHEAIHKADFLNTLSEYALEACRNQQQYPTLVSFWGGIMTEAVNGLLENMRSGRAAVQQDNNEAFLHRVGPTLAEAMSMKKVPNMQIASYMAVTIVAAKGSFDDATLSAFMEQIVHGWTSETVRPGLVCLCILAQYRSAKQLSGKVTKALLKVQNLGEILVELGQERRVDKLTNGLCIAFIERLCKKGDARGLPIIRAILMSKILKEKQIAVIFKSLVLAAHRLDDEVDKDGEIRKELGSTLIDLSRFSGETSEIIRTVLEEVDFDVEELEMKLDVSIRQRKALPGSQEDVEMTESKTPAPSKEDLRETIRELSTQKRALPSCLSTTTGEVYDEFSRLFLRVVSQQSEDPTLLADFDQLPSLSRQTAVSDHTYITFFVRIWSGPYPTLARAAAVDAVRRRLSDGDGNDLDFQALIPYCLVALVDSSKKVRRAAAELLIQIGHFFPPQSKAAKKSVWGGKNLYDDSAKVQWLEADTVSRLLHGVILPALEECIMHEDHIRAVLHSTLDSSAKNEGSDGKKALSSAGRSSVLSFLASHVVATPLLRVKSNLLSVLNRIRGVSSTSRTKVLLPAFQWWASLSAEETNRLSEVEEVDQAVLHTRFAEIVVPNDSEGLDCLLSIIKDSASAKRPELVRSISARIRAIWSSMKADTKFDVAQTMLELSQARHASQDEEDIIADEAADFLRNVELTTEILAYFLESIQTGTKLITEPPANKRRRTSSSEANRAVTAQASAELSATLRSVTFVLQLVDGSNPAAHPELLDSLFGTLSELQHFRTVIGSELGYLQNLVLTSLIAMVPAYRNNKSLKIDGSGGHGDLLVNCIQKSSSPIVQNSALLLIASLASAAPDLVLHSVMPIFTFMGASVLRQNDDHSAHVVNQTIKEVVPPLMASLKKGKRNPVAGATELLASFVTAYEHIPAHRKQGLFVALINTLGPDEFLYALLAMLVDRYGPNDSLMAFASELLGFYSAEVQLQTLARLLDLISDIFKPKPGLSATLLGVGEDLAEKKPETTALQQLTVFPSLLSSRKLRKEITVLTERDDMDSSKIRDLYAILLRDVLALAETVKNQKALHECCGNALANLLNLLSIGEFIKSVENLLDHTEIDLRRKVLRALEVRVDQEGVADVASRTALLAFLPQLTAAIRDTDDIKYKHTAVACIDKIAEKYGKKDVEAVAGAAATIAGPHCLGQPDTRLRVMALLCLASLVDVLQDGILPIVNIAISQAILYIEQSVEEEKAANELHNAGYAFITALAQHLPYMISAKHLDNIFLASNKSAEANLDNEADDERLNCLRFLARKVEAKTLLASLERNWIPATETGFDATDEWVDIFGVVVESHTKSVVTKNVTALSTILLNSLDLRRREHAKEKLGNTASQRVSKIEASINEVALKMIYKLNDAAFRPIFTHIVEWSTQLPKQDVAGRALRRFSVYGFLQMFFESLKSIVTNYATYIVDDAVEIIKTCDFKLPEQKELWRRVLSTLARCFEHDQDDFWQAPAHFSKAAPVLTAQFLNASSVDLSAELIPAVVELASAADSQEHQKELNSTILRHLRSEQASVRLAAVKCQQELAEKLGEEWLSALPEMLPYISELQDDDDEVVERETHRWIVKIEGVLGESLDSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPR1</accession>
    <name>A0A1B7YPR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA processing endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162459.1">
        <property type="nucleotide sequence ID" value="XM_018297643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPR1"/>
    <dbReference type="GeneID" id="28861750"/>
    <dbReference type="KEGG" id="chig:CH63R_02668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02668"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="691" mass="75111" checksum="4ED9B2FC34F26E2D" modified="2016-11-02" version="1">MQPDFEQRSKGPRACTTCAKAKARCISGPEGSNKCERCHRLRKPCGSQTPAPPRPKRDPRPTKVSELEKRLDELTTQLSTTQGSAGVSASAGAAVANGTVVGSANSPLPPSNSIKPASARIPINCDHLFPPAEVLMGDATGAGASDTSPAPSASTADDHHTVSSHGVSQPDIPGESPWPLNNEQNILLQTFVDDLQPLYPFVVVPPNMGPAQLAAERPYLWKGIQMTARHLDATKQVTLGNELLQDIVQAAFTKPRRNLDVLQGLQLLIAWFHYNINSYQLTNLLFLARSMCVSLGFKENPIQFKERGKGGACSISVQNSDADSKTKVQTKEQISARLELMRAFAGCYYLNTLVFTTNKRPDAFMNATHLESCCRQIEEVAEYPSDVLLVQLFKIQHLAQTISLTLGAESTSFQSLQLPLTMVVQSFQQQLDIFKTSIPDHLKNNLGLLTHVGIAEVLLYEIGIPESQGPASFISLTERLELLWGCCSAAKTFLDLRFPRNNSRSVQPRFTCLSSSDFLYVFIVSLKLMTLEVPGWDLPLVRKHLDLAGVVESQVEHLDVFVAHRSGRFRVATGGGGAAAATNTSTGTGAGAGTSPAASPTDVPGPNVVDPFLRLTEMLRYFKELLKGELSGFRSQPVIQEPIQLPANLSDGTQAMIRDLDANFWSSVLGEGDAETWDFGPMLPTMDWTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQC6</accession>
    <name>A0A1B7YQC6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_02967</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162758.1">
        <property type="nucleotide sequence ID" value="XM_018297942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQC6"/>
    <dbReference type="GeneID" id="28862049"/>
    <dbReference type="KEGG" id="chig:CH63R_02967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02967"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="120"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="552" mass="60253" checksum="4731B3C3C78168DC" modified="2016-11-02" version="1">MASRSRIQPLLRNAARRQSLLSAGGRHALRPVSAPAAAAAAARYITTTVVRPSKADGLKEIKLTSAAYPDIKRDSRFAEVTDAHAAYFKDLLGPSGVIDGVTADATDDIAAFNEDWLRKYRGQSRLVLKPASTDEVSKILAYCNEQKLAVVPQGGNTGLVGGSVPVFDEIIINMSRMSRIHSFDDVSGTLVVDAGVILEVADRYLAEKGYIFPLDLGAKGSCHVGGNVATNAGGLRLLRYGSLHGNVLGLEAVLPDGTVVDDLCTLRKNNTGYDLKQLFIGGEGTIGIITKVSIICPQRSKAVNVAFFGLESYEKAQQAFKAAKGQLGEILSAFELMDARSQDLVHAVRQNKRPLEDEHPFYCLVETSGSNGDHDYEKLEAFLEDVMSNEIVSDGVLAQDETQSKALWGWREGIPECLGHWGGTYKYDVSIPLKDLYKLVDDTKAKMEEAGLVGDTDEFPAVGVVGYGHMGDSNLHLNVAVRRYDKRIEKVLEPFVYEWIQERQGSISAEHGLGVAKKSFIGYSRNETMVGLMKQIKNLYDPNGIMNPYKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQD0</accession>
    <name>A0A1B7YQD0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162767.1">
        <property type="nucleotide sequence ID" value="XM_018297951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQD0"/>
    <dbReference type="GeneID" id="28862058"/>
    <dbReference type="KEGG" id="chig:CH63R_02976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02976"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="399" mass="41263" checksum="8D136E82C4E2A387" modified="2016-11-02" version="1">MSNFGNFMKNGWHPEKAGTTFKGQVNGLLGRNKDDDKEDRVAPPLSSLKDPSTFAPPPKRVPGAPPPRSNAASPSPGAPPPPYEDPSRQQQQQQEEEEEAPPRPYRVNTTGLSTSHLPPPPGRKDGADGRTPSPGQAAARPPPPSLPPRLPPRTPSATSVTSPAPPAPAASGGYLNQNAMNRLGAAGVSVPALGIGKPAPEPPTRSNAGSPAPPPPRNGAFSPPSGQMGELQNRFAKLGRSTGQSSSPPPPPAEGTTMEQKQAALRTASNFHKNPSTVSMADARSAASTFNNFRQRHGEQVASGVKSANNLNQKYGISDKIGHYAGRVGQQQEGTTGNAGAVPSPLSPPPGLVSAIGKKKPPPPPPKKKPQLSSAPAAPPGQSDDDEPPPIPLATKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQE0</accession>
    <name>A0A1B7YQE0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">QDE-2-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162681.1">
        <property type="nucleotide sequence ID" value="XM_018297865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQE0"/>
    <dbReference type="GeneID" id="28861972"/>
    <dbReference type="KEGG" id="chig:CH63R_02890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02890"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="323"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="542" mass="61046" checksum="4F14696F8A749A2A" modified="2016-11-02" version="1">MDRPHDEQLRMLLIRAFEKRMKFEEGPHQEVEEDPETIVLDPLALDHQTAAKKAATKGTSITKPTLGKAATHFVGPPLEPSRSDKLAPAALDALLKQDFPRFKNMKAGDLSEEGMTFVAWDLARRYPSSFIGKMNRPKAQPFFDDMTEEQTWDFFYVYHPQALDSNPYIFVPTEQFQHFLDVINASIQTNLTIPAGKPGEMFYVTFGPSCTIRPKYIARSASHNEYRAVRDTIPPPEKEDACAGATAFGKEMLLSLLNMHNNYKDTKTKSSKKKQEKAHNREESLYDAQLYLGLRPKASDVKNKEKETALDKPLPHAREQDVVFVCIDIEVAEEHHGTVLEIGLSILDTRNLAGVPPGENGRNWVPFIKNRHLITDEYRHIRNRKYIKGCPENFNFGKSEYPKLSDLGPSIIAAINNLSEAGKEDVSEADRRFRNIVLVGHDLRADLGFLERMGVELWTVGGVMSRTLDTKDMHQAWRHESQGRSLAMVLTDLDIPHSNLHNAGNDAAYTLQAMLGVAVAAMVDKSQKKNADLEVEEQPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQZ5</accession>
    <name>A0A1B7YQZ5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_03110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162901.1">
        <property type="nucleotide sequence ID" value="XM_018298085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQZ5"/>
    <dbReference type="GeneID" id="28862192"/>
    <dbReference type="KEGG" id="chig:CH63R_03110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03110"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="13">
        <location>
            <begin position="103"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="14">
        <location>
            <begin position="336"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115019" checksum="16BBF8508247D644" modified="2016-11-02" version="1">MDDQIVNAVEAAFNPGSDQDLKQQAFNYLNQLRTDPQGWQVCTSLFTRSQRPSEVVRLFCLEVVNYAIHTQALDRGSLTWLKDNLLEYVRNIYGQNLQDQVDPPHLQNKLSQTLTYLFVFLYNDGWDTFIDEFLAMANSPNNTAGVVLYLRIIGSIHDEIADMLLTRNSSDAKRNTDLKDQLRARDVQKVAQSWKDLLTQYSGQNDIIVEMILKVIGKWISWMDISLIVNQDMLNLLLPVIGRTNNSGSEDKVRDAAIDTLTEIVGKKMRGPEKMELISFLNLRDIVAQLIASAPLSELKSTPKYDTDLAEAVAKLINTVMADIVRALEDAQAGDDTRAKSEQHLHDFLPFLLRFFSDEYDEVCSTVIPSLTDLLTLLRKVGANLPASYKEMLPPILNAIIMKMRYDETSNWGDEDEQTDEAEFQELRKRLQVLQKTVAAVDQELYIEVLSNLVSQTFSTLDQQGSHMDWRDLDLALHEMYLFGELALPNQGLGTKSQPSSTATERLTIMVAKMVESGIANFPHPAILLQYMEICVRYWQVFDARQEYIPQVLENFVRLVHHDHVRIKTRSWYLFQRFVKFLRAQVGNVAETVIQSIGDLLPIKAEVSENNGDDDMSSDESDHSADALFTSQLYLFEAIGCIASTGSTPADKQAYYARLVMNPLFSDMESHLPKAKSGDAQAILQIHHIILALGRLAHGFSDWQPGSTSAQNRPPPDKLVSDEFSRAAEAILIALSELNSSTDIRTACRASFSKLLGVLGSAVLPQLPQWIEGFLSQSSSKDEMAIFLRLLDQIVFGFKAEIYNVLNMLLTPLLQRIFAGLSEPVTGTDDEIQLGELRREYLSFLLVILNNELESVFISEANQGFFESLVNSVLTLGRTLVAENIGPSRLAFSVLARMVVVWGGPDCAKIAENPSAPSGSPNPSIPGFDRFMIDRFHPLCWEVFQDPNFRPHNDAQSKQVLNEIAGLEQAIYTKTGEMFIQHLQSSLFPHLGIDGSDFLRSMSTSVDRKGFSSYLQGLLKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRX5</accession>
    <name>A0A1B7YRX5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163221.1">
        <property type="nucleotide sequence ID" value="XM_018298405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRX5"/>
    <dbReference type="GeneID" id="28862512"/>
    <dbReference type="KEGG" id="chig:CH63R_03430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03430"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="78" mass="7909" checksum="248E6B3A151975B6" modified="2016-11-02" version="1">MAHERVREGGAAVGDIPCWVSRQEGIEDTRGEDVAVVLLDVGDGDGDETGVSGEAEQLGERGCHAGLAAAAAPPPPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU44</accession>
    <name>A0A1B7YU44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163971.1">
        <property type="nucleotide sequence ID" value="XM_018295609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU44"/>
    <dbReference type="GeneID" id="28859716"/>
    <dbReference type="KEGG" id="chig:CH63R_00634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00634"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="532" mass="58564" checksum="22B7B348D57DC2BD" modified="2016-11-02" version="1">MATANEEPPSFRTDSPPPELSPTPAIGACPELSRCVSTASSVSHGSAPDAASRESLGSVRSSAYSRQSSGTYSRRSDVSLASSQQSSCSGSRQGGGRSSSRRRGFVRPQGTDFAASARHRESVLSLGSIAHLQYYFARTGLLDGKGAQLARKNKAKGGLDLSSVSSSSSSSPRIVDSEGSSPELGSHPFDAGPIAESPMEEHDYYSDDFDEPDPDVLPPTASTYIHRNKPVPKPPTIQELKADLTGTLEKAAAAARHTRANREPLPEIPPRKQDKQSTPKKGQGQGWYEVQGMHILDVMTLAIRAARNYYTAHEVPERLDAIKSEKEIRAELLSVMETLKQMATRNWAGGMKDEELRILESWIQGLFDMLKKEEELMKAEEAQRSTWTWLSGDWTGKEVERELAFMASLDPSAGPLPEYTSVVDATEPPTPFLQALQNGIRLVELHNAAVKRSKRRFGLITTFHTDTEKPYRCADNIRYWAKAAELRWEVLLKVDALGIVYNNSPDVWVNFEKAILAWSCKVREEITSELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUC8</accession>
    <name>A0A1B7YUC8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164158.1">
        <property type="nucleotide sequence ID" value="XM_018295796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUC8"/>
    <dbReference type="GeneID" id="28859903"/>
    <dbReference type="KEGG" id="chig:CH63R_00821"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00821"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="20947" checksum="B97A13EFCE4F874F" modified="2016-11-02" version="1">MTKYVLCEEETVRRREETIPGRSPDDPRTTSGAEPVSGRPRPETQMPPERVPSDEPIPEGTPSYNSTQDKPVWPRPASPAQRDPQRHEERPQNGSVTAACLSATLFFPLFLSTPARPADANRKTKKKKRSSYGARHGPKNPVPSPAKALYLLSYIYPANVTRPRHPSYDTLRASYAIIIIRESRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUL5</accession>
    <name>A0A1B7YUL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164263.1">
        <property type="nucleotide sequence ID" value="XM_018295901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUL5"/>
    <dbReference type="GeneID" id="28860008"/>
    <dbReference type="KEGG" id="chig:CH63R_00926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00926"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="61923" checksum="DA962C5CCA5303BA" modified="2016-11-02" version="1">MLTSRPMRPLPGPQILTFALENWPYNSGPVSRASKPKVRTGCITCKRRRIKCDETKPSCQNCLKRRVSCEGYELKPPRASSQPQQFFRSSHSPILVEPSYQGLVFTTQLQKDHFDQWLSFAADILVFPSQLITDTIPQIARSDLAVRNAAFAIGAAALGSSTREERLAGKGPYYADALGYYNRALKLTAKSPPTEETFPGVLMTCLLFFMFEALQGGRKAALTHLNHGNNILNQYEKRVHNRRDPLVAAIASNFQRLTLQSWSHNGDHPKETEAQAPWCCRGQTRRYAVDEMPDTFGSLDEAHRWWEITQHHVIHHAPILIGFRVEGTGNKAPSFPANQSLPIPPEHVKGYNRFIEAWRARFKPLLEAQERTEMDDKERLKALGLRIHSAYLSIPILTANYTDADALTQMTPVFREYVALSEEFLHLQKRLTKLDGETFTVDSNSPTWPLGAAAMLCVDGAVKADAVQLLRGFPRRDGLWDTQVWMSMMQSYESANIVIAGRAGGDKKEAQHLFDVEVVYDDKSVAWIRQAEDPSSASPEELEYRINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUT8</accession>
    <name>A0A1B7YUT8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_00963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164300.1">
        <property type="nucleotide sequence ID" value="XM_018295938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUT8"/>
    <dbReference type="GeneID" id="28860045"/>
    <dbReference type="KEGG" id="chig:CH63R_00963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00963"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="234"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="59185" checksum="2444395677F25A24" modified="2016-11-02" version="1">MKGSILAVAAAVGGVSAAAHRHSHGELFKRGADQASVCVPGCTTIYTTIYGEPTLVPNPPSKPSSKSVASALPSVPATTKVPAKPTSTQKPSVDLPTPVPELCPTPGTYTFPATTITVSQTTTVCAPETTKVPAGTHTFGGVTTVVESATTVVCPYATEKTKDGVVTSVVETTTYVCPTPGTYTIAPTTTTVTAPTTCVYPVVTEVVPGTYTRPAVVTTITETSVVVVCPFTSEEPKPTTTAAPPKPTTEAVKPTTEAPAPPPVPTTPAVVTPEPVPTTPAKSSSAPAPSSSAPATGGGLGGNNGDHWAITYTPFSEDASGSCKTADQVDADIATIKKSGFRTVRVYSTDCSTLENVGAACEKYGLQMIIGIFVKESCDPNSADIKNQLDAIVNWKKWGMVELVVIGNECIFQGRCSASSLKQLIVSAKATISGAGYSGPFTTAETVGVWQQTDVISEICDAIDIVGGQIHPYFNAETPASAAGTFVKSQIELLESSNICGNKPALNLECGWPSGGNCNGKACPGTSEQAIAIASIKELAGGKTVFFSFHNDEWKEPGVCGCERTWGCGELFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV51</accession>
    <name>A0A1B7YV51_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_01012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164349.1">
        <property type="nucleotide sequence ID" value="XM_018295987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV51"/>
    <dbReference type="GeneID" id="28860094"/>
    <dbReference type="KEGG" id="chig:CH63R_01012"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01012"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="979" mass="107524" checksum="338AF3E4FB1D276F" modified="2016-11-02" version="1">MDSGHYSSAARHAAAAAAAAAGPGGAVYSAHPIDHHAHAAYHHTHSHLQTPAHSPHGQPQYYPMNPLSPSAQGPSMTSPRVLPNSDFIPAGQSPGSATSSVPHGRPAPPAGPVSPAASVSGAPSPSTKPIRRRMRMITSCLECRRRKLKCNKSQPCVNCMKFSRDCVYLSPKLDEASQLRLTEIKEKVGSLERQLERDVAKTTSRAAMQQAILADDVEDDFAEERDLEPTDMTALDVTYEEDADGTDDLIDLGVQVGRMRITERIGGLSRPRIAEEISAGISGQGGPGGPSSGGAMGGMMGMMGGRGMGGAGRGGPPRGGPPPGYPGYTGPPPGMDSMSVISGSSNDSIPDFLRPGESYIPPSSGFFFGHTSEALSLDRRLPQKEAADRLTQQYFQAVHPVARCVHRPSFENEYRNFWDEVYNNIEPRASTQAIMFAAWFSAAVSMDDATVRELFGVTKANLIERMKTDTERALGKANFLRTTRVETMQAFIMYMVRFVSPLMILSIADFLTKLPLCRAEVSRAHSVLVGAAVRMAECMGLHRDGETYGLNPLDTHVRRLIWHQLCFLDIRTCEAQGPRPAIRREDYDTKLPLNCEENDLYAAGPSPEPAEHFTSTLPSLIRFECNEMMRIIWLDRRRLESRRTTLTAVLTKIENFRRRMVEKYDHFLDGTIPIQRYAKLVMNLLLYRLHAMILHPYYANAGSPMTHRLNNLLITSGIMIVEISIQLDTDQLFHEWSWYLGAYQQYQIALLLATEIYYRPQNQEAHRIWACLDYVFKTDRTLPPEIKGLQILGEIMGKMQTYQGMRKMRAPTGTSRAAPSRNAVGGKNDSAGLQPPPQHYNAQDVQMGFKTEPGMSGGTQQQQQQHSPMSGMGSPGMASPNSQMGGPPPGIVFAGVSNGEAIWSMPPVNADSPESISDGASIGGHRPSQPVNMMNSLEGVDWDIINNLFPHDPNTGELNISGFNDPSLGLMNGYHWVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW29</accession>
    <name>A0A1B7YW29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164766.1">
        <property type="nucleotide sequence ID" value="XM_018296404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW29"/>
    <dbReference type="GeneID" id="28860511"/>
    <dbReference type="KEGG" id="chig:CH63R_01429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01429"/>
    <dbReference type="OrthoDB" id="10336462at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="347" mass="37584" checksum="1135FA13529E2979" modified="2016-11-02" version="1">MVRPSGSKVQLDEPFKVVAALMEWRMAASKLLVKSPTITWRVGSPLYAAGGSSHAPQSPTTSLMTAKVLPLKDSKLSSTPVPTFGAGLNLLTFGSPWYSPKPIHRTAALSPATSSVQLCPHFTPSFPPALVQLPRDYAGYRPEDEASSSPVSGQPQPQLPHPFSSRSGTMSPGQAGTLSGLVVTSAYSPGISTSRDGAQPPQFGDVPALISSWNYAGSMPSVRELIREVDAVFGPPWDRPELEQPADPRAAPGYAHGEYVLWLLRHLVYVERAADGQVVTYYSIGRPAVEWHGVPPATDFEQANEQHEEEVPVEDELAGFLSDVQPEFLLAERWQHPNPQPESPELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWK4</accession>
    <name>A0A1B7YWK4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018296574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWK4"/>
    <dbReference type="GeneID" id="28860681"/>
    <dbReference type="KEGG" id="chig:CH63R_01599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01599"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601982" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="201" mass="22640" checksum="4762026504DB5FE7" modified="2016-11-02" version="1">MLAARILIPAFAAVVVSGLDAPIPGYSVFTPEWEVQVTPGGESVLMNGTVEHVFDELTNFDPVYTEALMKDFTALGHDRLGALEQREDWRTRPYICRDYPLARVDAAWDGIRYLRTLKGKPKSSAGPSSCGQISCSWSTAIWWCNDDSEKKELESYKVIADGAQYMWDACTPWETSRYWSSGQIFSNDGWNIIIKKSESYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVR2</accession>
    <name>H1UVR2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_04521</name>
        <name evidence="12" type="ORF">CH63R_04721</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02000311">
        <property type="protein sequence ID" value="CCF32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160942.1">
        <property type="nucleotide sequence ID" value="XM_018299696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVR2"/>
    <dbReference type="STRING" id="759273.H1UVR2"/>
    <dbReference type="GeneID" id="28863803"/>
    <dbReference type="KEGG" id="chig:CH63R_04721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04721"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_1"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="243"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="329" mass="34408" checksum="B973A9BE90984F92" modified="2012-03-21" version="1">MAPSKTPQITVLGSLNIDLTSYVPHHPLPGETLTSNSVVISPGGKGANQAVACAKLSRSRDAPNDTAAESASVSMIGAVGSDSYGDLLLKNLGEHGVRTDRIAVGDNLKTGMAIIVVDEPTGQNRIILAPEANHAVTPDKFGALPETLDPKPDLLVMQLEVPLETVLAALRSAKAAAVPVLLNPAPAQRLPDEAYDGLAHLVVNETEAAILSGCDESELDTSDGLKRVGEWFMAKKVRNVIITLGGRGVYYTNQDGAAELISAQKVKVVDTTAAGDTFVGSYCVAAVNAQAKGEAFDISVAIINANRAAAKTVERKGAQTSIPWRDELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW19</accession>
    <name>H1UW19_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_04609</name>
        <name evidence="17" type="ORF">CH63R_13437</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR04310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018308411.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1UW19"/>
    <dbReference type="GeneID" id="28872518"/>
    <dbReference type="KEGG" id="chig:CH63R_13437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13437"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001482_1_0_1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
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        <property type="entry name" value="Chitinase_insertion_sf"/>
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        <property type="entry name" value="Endochitinase-like_sf"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
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    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH18_1"/>
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    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="356"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="422"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="565"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023295"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR04310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1427" mass="155868" checksum="A25AA656C1513071" modified="2012-03-21" version="1">MVRAGQRYFLPLVGSLFYRGAISQQDLCPTTCVVSGPDPANWTTVGEFGQLQACKKPLVLDFSVTIPVTEKQPIRACNVFANDFYAGPVDPPASGGTEDIAPIMAWTPAGSENETGGLVASQPVEHLQSYLQNVISRAANRTILFATASDVTVGVYVGANLLNPSVAGTFFDYLLAVLFGPGIADEKAALIQACDGRSGDQIFGLIAASTPDFTTVHNAVARWSNGQCVDTSSYPEVFDVDPEPIDMVDSNTALTLSSGARVGLSNSTDRKNVTSPAVRGLLLARADCRTIDVKSGDDCGKLVTRCGGGMTAADLYKYNPKSTLCSTLQPGQLICCSAGSLPKPTTPQPNPDGSCRTQKVDEGDDCSKLVTRCGGGLTAAQFYQYNTKSGLCATLQPGQHVCCTPGKLPDLRPKKNADGSCFAYKIQDGDFCAKVAAANGLTVDELEKLNKETWGWNGCENGFWPDNWICLSEGTPPFPAPIANAVCGPQKPGSTKPSGSTSRDWAKMNQCPLNSCCNIWGQCGTTEDFCIDTNTGPPGTAKKNTYGCISNCGMSIVQSGPPAQFIKLGYFEGFNLGRNCLNMDATQIDPSFTHVHFAFGMIDDNFNVYHEDELAEFQFQQFKKLRGPKRIISFGGWVFSAEVPFYHIFRNGVKPENREKLADNLVKYVVDNGLDGLDIDWEYPSAPNLGEGVPEGDPSEALNYLRLLSRLRAKLPKDKSLSIAAPASHWYLKQFPIKAMSELLDYIVYMTYDLHGQWDAGNKWATPGCPTGNCLRSHVNRTETMNTLVMITKAGVPSNKVLVGVSSYGRSFQMANPSCTGPNCLYTGDRLTSYARKGRCTDTAGYISNAEIDEIKGRSWLDAESNSRIMVDGDLWVAYMDDSLKDSRTQMYKRYNMGGTIDWAVDLVKFHDPPKLLPDGINLGLSWASIKANVRMGESATCNPSARTGTWVDKQCTHDAVGDNTKMTPKARWDALDCKSGWTDIVRRWQGCDFKEGGKEDFSEHIASYLRAPSRPRCNDLGQASSCGVMQCAAHNTPETNPERKTGACAYELWNGLAEIHTILRNYYYSLESTGNSLARRKDTFIETFAPKPDDDSKIFDLFLTLMPIPLTAAVPRFFGSALASMKYFSGATGGDRRAAWEAGTITMVGTAFSIAKDALDSASSAREEIAFNDIFDKIITNWKAQVNRLVAQIFNGSPESVKLLSALVSDGKMIQGEEDQPASGYTGEYTKSWEDSKYIERAFYALAIPVLWAADRPTPFILDFGDSCVIDATKYFEERADKYNAGWRCPNGHSYILAGVDDEPKGCPHANPRLCLLPRNRNFFKILKGIDELKEPGQDRWGKVTVDDLIIGAVNTYKKNNGRNFMDPAKSMTDPADIQRLQNVASQDIRLGGFQHIPICGPEEARANLLKGRKAYGNSPNYPCNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWB8</accession>
    <name>H1UWB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04685</name>
        <name evidence="3" type="ORF">CH63R_13930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000374">
        <property type="protein sequence ID" value="CCF32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151222.1">
        <property type="nucleotide sequence ID" value="XM_018308904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWB8"/>
    <dbReference type="GeneID" id="28873011"/>
    <dbReference type="KEGG" id="chig:CH63R_13930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13930"/>
    <dbReference type="eggNOG" id="ENOG502T6QP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059757_0_0_1"/>
    <dbReference type="OrthoDB" id="4844974at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="432" mass="47486" checksum="A5E81C831C3D2037" modified="2012-03-21" version="1">MAEVASGIDGKRRNLPRGGGGKYKWSLQPHHAIQWQKDWLDLAAKLFNTDADDVLLTQDEKNEVLSLLARKITDSNISYYSRAVRACKIVDSVSRMCSGKGTCSGVNLFTALLRYSLMPPSAWLGVRDIRQGLAALQFLERCSNGKDTYTAEKVREVMNMEPVVAAEPQQRDDDLGLLLPPLRRASTFENPAPPSTATESSMMGVRPWTRAMTTFFSPPKPATELNAALKPAGQNETTPSKQVSKPRKIKTPQKGKESPAAKSASAKAKGKKIAQVSDEVGSPTSGTLRTQRKRRTAPADKSITDAHLASMFKATEVLGKVAQYEEECVREIALSTFVADLQKARWDDLEKSVKQLIKDTEYESRAFLAGVIVSRTYERINKALNLEPAPNTAHDKKFKSSKVLIKKPKPSRTSPVKAAPGGRTTKILFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX06</accession>
    <name>H1UX06_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00816</name>
        <name evidence="8" type="ORF">CH63R_01374</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000446">
        <property type="protein sequence ID" value="CCF32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164711.1">
        <property type="nucleotide sequence ID" value="XM_018296349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX06"/>
    <dbReference type="STRING" id="759273.H1UX06"/>
    <dbReference type="GeneID" id="28860456"/>
    <dbReference type="KEGG" id="chig:CH63R_01374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01374"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_1_1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="204" mass="23334" checksum="6D7957860F5AFC63" modified="2012-03-21" version="1">MSVEGKKLETASKDATPSNPRGIPKAPFVDKVEDYVTTREDVEPTMRNFQEMISKYQFMELNLQKRMAGLKDKIPDIQKTLDSVRFLKLRQGDDEPIETTFELNDTLYSKAKIPPTEEVYIWLGANVMLSYPVDEAETLLESKLSTAKTSLSNCEEDLDFLREQITTMEVAIARVYNWEVVQKRKDKEEGKDIKKEEGDGKANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXJ1</accession>
    <name>H1UXJ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase Rpb4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_05027</name>
        <name evidence="7" type="ORF">CH63R_11826</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
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    <dbReference type="EMBL" id="CACQ02000505">
        <property type="protein sequence ID" value="CCF32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018153641.1">
        <property type="nucleotide sequence ID" value="XM_018306800.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UXJ1"/>
    <dbReference type="STRING" id="759273.H1UXJ1"/>
    <dbReference type="GeneID" id="28870907"/>
    <dbReference type="KEGG" id="chig:CH63R_11826"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11826"/>
    <dbReference type="eggNOG" id="KOG2351">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_110332_0_0_1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:RNA polymerase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DNA-directed RNA polymerase II subunit rpb4"/>
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    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
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    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
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        <property type="entry name" value="Rpb4/RPC9"/>
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    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
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    <dbReference type="PANTHER" id="PTHR21297">
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    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HRDC-like"/>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="142"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00657"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="9">
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <name evidence="9" type="ORF">CH063_05284</name>
        <name evidence="10" type="ORF">CH63R_13193</name>
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    <organism evidence="9 11">
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        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000611">
        <property type="protein sequence ID" value="CCF33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152584.1">
        <property type="nucleotide sequence ID" value="XM_018308167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYG2"/>
    <dbReference type="STRING" id="759273.H1UYG2"/>
    <dbReference type="GeneID" id="28872274"/>
    <dbReference type="KEGG" id="chig:CH63R_13193"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13193"/>
    <dbReference type="eggNOG" id="ENOG502RSJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_1_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
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    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33013.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR04066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="421" mass="47229" checksum="D92A09A774239083" modified="2012-03-21" version="1">MSSEADRFIREVWGLQGAAYLVVGLRYYSRISTLGWQKFAWDDALMGLATLVYTAEAVAAYFVVAYWRGLANNGMTDEQRAAVDPASEEWLLRVNGSKTHVIGLLLYTTLLWLLKGCWVVYYSRLTNGVHNMKRIIFWAAVIMPATYVACLLVAFCKCIPFQNQWQINPSPGNSCMPAISFVQTIFVMAMNTATDFYLMAIPLPMVWKSHLPWRKKATLMIMFSGGFLEMAFGILRCVSILTVGDVDPAQSGYWSVRESFVSFVLTNMPMVYPLFKGVIEKSRNLSTNNNSALSDSNGYRLGSYTGKQRPKSGSHPLSIPNGTKWGSDEHIVPGTADKSISDGEEAFVKAFDRVYRCPQSPCLRQGFNVAKVVVGNDQGYFQSMDGGNHLVNAEKHQITVTTEYMISRATPEPEMQERRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYP1</accession>
    <name>H1UYP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_05349</name>
        <name evidence="6" type="ORF">CH63R_05046</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000639">
        <property type="protein sequence ID" value="CCF33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161267.1">
        <property type="nucleotide sequence ID" value="XM_018300021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYP1"/>
    <dbReference type="STRING" id="759273.H1UYP1"/>
    <dbReference type="GeneID" id="28864128"/>
    <dbReference type="KEGG" id="chig:CH63R_05046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05046"/>
    <dbReference type="eggNOG" id="KOG4192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_2_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16552" checksum="0AEBF382F41E0475" modified="2012-03-21" version="1">MDAPGEDLKLYTGGCECGAVQVALKSKPLNDIEIKEDNCSICVRNGFIGVYPHQSLVTLVGKDQTQDYKFGRGFNGSPFCRICGVHCFGNLYGPPEEVLARLPEAKQDFVRKQLEVQPLNIRVLDGVEWDRVDIKWKNEGTEGYVLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZH6</accession>
    <name>H1UZH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_05582</name>
        <name evidence="11" type="ORF">CH63R_02986</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000733">
        <property type="protein sequence ID" value="CCF33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162777.1">
        <property type="nucleotide sequence ID" value="XM_018297961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZH6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02986"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Stress_Response_Reg"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
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    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="Fungal_trans"/>
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    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
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    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="788"/>
            <end position="867"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="885"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="981" mass="110092" checksum="CA96566E14E289CD" modified="2012-03-21" version="1">MSPPSRPVKADNSPPDSNMSDNESAAPSTNGWPVKEPPSPSGSAHSGSDMDEKPGEAGTNAPVQKRRRVTRACDECRRKKIKCDGKQPCTHCSVYSYECTYDKPSNRRRNPAPQYIEALESRLQRAESLLRKFIPDVDLADPTLDPAVQQEFRNREHARGQTSKPRHDPYVVPERGDAQLLSMIESIGQLDLDDRGGWDFHGVSSGAVFLRRMKEHFRGMMGPITKVPFLPRPDRPAGLINLDSPASAASSPFDSTMSTAPELPPKEVARNLCYLSLNCATCLIRIVHVPSFYEMLDRIYEKPYEDYSKEEHRFLGLLNAVMALGCMYRNLDENAPSVAYKESVDEGMKYYDTARRILQDITECRDLTSLQALLFMILFLQATSNLSGCYAFVGIALRSALRIGLHRFLKHEKISIIEQEVRKRVFWVIRQMDIYVSAMLGFPLMLNAEDIDQPYPSEIDDEYITDEGILTPPPGTFSFFEAFNAHTRLMEILARILKFVYPLKGLGQSVMKGDKPGATYLISYANIKRIEAELQEWYEVLPAQWRPRPDGPVEVIRVRHLLRFAYAHVQLVLYRPFLHYVSPRLGVGKNIDDLSYACAAACISVSRNIVHIGIEIRKQNVLAGPYWFMLFTEFFAILSLVFYSIENPEKIGSAEVLEDAIAGRDMVAKLQSKSQAADRVTEALNVLFEQLPERLQEAKSRPIPTKKRSAPGQKASSVPVHGHAALQPGIGQRRSEELSRPPSVVMANGRMHQPPLRTSFDDVPISEAGYQSASLASNIQDLLGMDMSSRATPDSVSTSASSNRPTQGFPPPHSMTHLGKLDSLMFPSEDPFAYPNQPMMELGFQKGPGPNNVSGPQDSSTFMMPGAFDDIDTQLLGQSPAYFLQGQGHHHQQQQQQQQQQQQHQQQQHQQQQQQQQQSGYDLAGMYQHPGYQGMPDAARLEHARRAHMQQRPGELERMLAETGYQGNWAGMLARNGFQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZS6</accession>
    <name>H1UZS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05666</name>
        <name evidence="2" type="ORF">CH63R_08847</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000776">
        <property type="protein sequence ID" value="CCF33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155844.1">
        <property type="nucleotide sequence ID" value="XM_018303821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZS6"/>
    <dbReference type="STRING" id="759273.H1UZS6"/>
    <dbReference type="GeneID" id="28867928"/>
    <dbReference type="KEGG" id="chig:CH63R_08847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08847"/>
    <dbReference type="eggNOG" id="ENOG502SI13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031053_0_0_1"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="412" mass="45644" checksum="EA8B0A563306C08E" modified="2012-03-21" version="1">MVVFVDLDEEMEPLHVLEARRLAAAAAIATHGLEPTSRELNHELEKPMGAPVVSVAPVPAPEPTPAFQSAATEAFGCYPIVMSIAEHIDLNTLDSLARTSRQVRRGLLQYRSILLSSTLHCSNEGTPVDPESTFRFRARAGNWYYMEDGRNYNGKSGSCARDLVTECRRCRTVVCRNCAIKPPAHNALRERHRRLCNPCIKAPIASLVNSALETETPLLDDAVRREICRCDIDGVWLCQPCGRSMRGDDHEYQRIWKWRAHYGEVLGGLGTGIGEGDRGVICGRGSACAGAKERENETDCDAEDAAVSGANLWTATNQVHLDTVRYERTPSPQLGPGYERHEIEGIGGCVKTKLIRMVRVGACVPEWDDEKSHHSILRREVKGIRRSWCGWCYGVIPGEADLKKVGATMRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0U8</accession>
    <name>H1V0U8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05953</name>
        <name evidence="2" type="ORF">CH63R_13636</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000917">
        <property type="protein sequence ID" value="CCF33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="200" mass="22611" checksum="509DF1C1EE2FCD20" modified="2012-03-21" version="1">MINLVNGLLIPFSMTDPSLLDLRSRGSPDSLAPMERQPVQCHSESDFPGHADVNYGMQWEAVNAFCKTKHLATTLSTLHDPADGRYPITYRHRMRWRDWPHRINYDFFVEWVWGCRTTSHFQSVGLPLGKGGVTCHTVMRDNFLQCNNGGVGGSTQVGCLLFTFTGANGSKCILTEEEMRLRDIYDKKHGIKRPETTCGM</sequence>
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    <accession>H1V3C5</accession>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001250">
        <property type="protein sequence ID" value="CCF34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28868255"/>
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        <location>
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            <dbReference type="EMBL" id="OBR07653.1"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001314">
        <property type="protein sequence ID" value="CCF34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154279.1">
        <property type="nucleotide sequence ID" value="XM_018304855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3T6"/>
    <dbReference type="GeneID" id="28868962"/>
    <dbReference type="KEGG" id="chig:CH63R_09881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09881"/>
    <dbReference type="eggNOG" id="ENOG502SAXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059771_0_0_1"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09807">
        <property type="entry name" value="ELP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29371" checksum="4E31AA283844D059" modified="2012-03-21" version="1">MATRIPHVLESYLALPPECAQILLTSVLGASTNWLVLRYLYSYLRKPAAADEEASPAEDIRVVLVSFMRDFAFWKEGASRLGLDLEGLGRSGKFVFVDGLSSLFSQGKTAPGRPAVKGKRVLRSAKLPDVQRELDAAISDVSAAGARTILVLDQPDVLLAASSEDLDGLSLRNMLRDVQEKVHATITAVAADEPLVAAQATTLEKEHASLVLGLAHAAEMVVGLRLLDTGNASDVSGVLRITAGGDAGSSGERVVEETELLYFVGGDGSVKVFGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V460</accession>
    <name>H1V460_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_06880</name>
        <name evidence="15" type="ORF">CH63R_00993</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001361">
        <property type="protein sequence ID" value="CCF35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164330.1">
        <property type="nucleotide sequence ID" value="XM_018295968.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1V460"/>
    <dbReference type="GeneID" id="28860075"/>
    <dbReference type="KEGG" id="chig:CH63R_00993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00993"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_2_1"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1031"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1298"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1322"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR15813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1396" mass="150701" checksum="9438BE89E1EEC446" modified="2012-03-21" version="1">MTTSELAPPSPARRKRRSRRRRQDKPAITARLVLDDHDVRGDVGIVSEDLFIDLFPHLRDAPSREDGSDDIHHVAIAPWEPTPSSTETAWTVVPVVKSTALKHSTVQFSPSSLSLQNFATILQQVAPSKLSSSSRSGIEIQILDIVALSLDTVYVSLESELTKRLEQGEGTFYRDHPSNANGKGHAAPETSEVRLISSLRVALGSLRVLHSGDLFPLPLPPHPVTHIPPNPGKIMLCEPVSQGILSENTKIVLMRGRVQAKRGQAAPSIPPNRSLNGVPEDEEDDTANDQFFSAAEDRYKTDAANTEIDSVTETEESELSGIDQDDDLSDDSMDDMISLQAPTLPTTAASGVSTMQPGTPMTIGRGRKTNGIATPASVFSNYTATTARPDRPRGRLFRAQGLIRTVPVDLLHPKPAPEDDDEARVFVDIASLSKIGCFSGDWVRIEAAEEPPANGFGAFGLGSFTSLEPVESTWRPVRVYGLPEGYSQRPVTRIPNTKHGERRLSFFDSQLQKPSSPAAYISPILLANLDEPSYLRLSPIKRGTYQGKGTLPKFTSASRPPYARDITIQHVRSPVTAERAYQSAVLGGLKRYFAQKIRLVRTGDLIAVPIDTQLGKALQEQPSGSNGSEVDDVMALSKEGSSRFDQVAWFKVGHIQISKSDADNDQSEELWARVACIDSSSVAMHGSGFATNRIPATKCNTWPYYLGVKKMPTKAPSASALTLPDQDQRYISPLRRRLRELLAAATSPRAVHLKMPPVAVLVTATHRNIGKATVASEACADIGLHTYAIDAYDILSEAGTSGSDVKTEGLLRTRAERAMSCGPETTALLIKHVEALTADRMVSTLKEVLQDTRVLIATTSDVDKVPDGVRGLFSHELEMGAPDEAEREGILRAIIEDRGINLDPEVDLNGVALKTAALVAGDLVDVVDRALIAQRLRLEQISSKAEAAGQAVTVRDLQVAGGPMARCVTKGDFEVAVEAARKNFAGAIGAPKIPNVTWDDVGGLNNVKDAVTETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEYSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSGGDDTSGGVFVIGATNRPDLLDPALLRPGRFDKMLYLGVSDTHDKQLTILEALTRKFTLHPSVSLQSVAQRLPFTYTGADFYALCSDAMLKAVTRQAAAVDAKIRDFNADRDPSRPPMSTAYFFDHHATPDDIAVMVTEDDFMRAHEELVPSVSAGELAHYESVRASFEGSPDKDKQQQQQQRPAAAGLRAVSGSSAMSRGSSKGKGKAVSASSKGKGKALALDSDDEYGSESEVAVTNGKGKGKGKAIAGFQDGTASDDEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6M0</accession>
    <name>H1V6M0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB family carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07568</name>
        <name evidence="4" type="ORF">CH63R_04509</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001733">
        <property type="protein sequence ID" value="CCF35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160730.1">
        <property type="nucleotide sequence ID" value="XM_018299484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6M0"/>
    <dbReference type="STRING" id="759273.H1V6M0"/>
    <dbReference type="GeneID" id="28863591"/>
    <dbReference type="KEGG" id="chig:CH63R_04509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04509"/>
    <dbReference type="eggNOG" id="ENOG502QTK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032834_0_0_1"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01943">
        <property type="entry name" value="MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034094">
        <property type="entry name" value="Mak32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="338"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="415" mass="44909" checksum="028CAD8D1E1F1DD8" modified="2012-03-21" version="1">MADVDSQAPPEQRLTKEEFAALPPIDFVTLGMFIIDEIHFLPPTPPVYDILGGAGSYGALGARLFSPPPNASSVGWIVDMGSDFPLSLTDLISSWGTSVVLRDDPERLTTRGWNGYESAEKRAFRYTTPKKRLAAGDLTPHLLLSRSFHLICSPARCRDLVTEITSSRKRVCPPDVYTKPIFIWEPVPDLCTPDELLNCTNTLPLVDICSPNHSELAGFMGDDGLDPETGDISKVAIERACEQLLASMPLSSFTLVIRAGAKGCYVARNGGRKRQSNTWDDAGPKRRKKEYARGGLQPDTDIEALFAGLLQDGDGVVVREEVEIDSGIGQWISAVHTDPAKVVDPTGGGNTFLGGLAVALARGKGVEEAATWGSVAASFAIEQVGVPKLDQDENGIETWNGVKVEDRLAEFKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7R2</accession>
    <name>H1V7R2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterigmatocystin 8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00222</name>
        <name evidence="7" type="ORF">CH63R_11293</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001902">
        <property type="protein sequence ID" value="CCF36264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153108.1">
        <property type="nucleotide sequence ID" value="XM_018306267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7R2"/>
    <dbReference type="STRING" id="759273.H1V7R2"/>
    <dbReference type="GeneID" id="28870374"/>
    <dbReference type="KEGG" id="chig:CH63R_11293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11293"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF36264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="421" mass="46769" checksum="7463AF4C9B6623EC" modified="2012-03-21" version="1">MAIAKSTPRIVELATQISKSVADLQAVLDAKGVPSPSFDENAPPKLPKEANDAQDAVLDATAELHDLLLEPVTLVLKNSANNSMGSLGFMCRFDIPNMVPLGGKLSYAEIAKKTGFAEFVVSRFMRDCVCMRIFRETEPGVIEHTKTSKALRAPWFLAWLRAGAEEGWATMLGVVDALQKWPNASESDQTSFNIMHNTTGSYFENVANDPEKAARFGAGMATQWEFPGYQLEYLLDGFDWAALGPVKVIDVGGFKGRISIALADRFPNLNMLVQDMGMNEKEAHAAVPDELKDRVNFMAHDVFGTQTESADVYFIRQVLHDWPDKYGIKLLRSQIPKLKKGAKILLNESLLPETPGSSLPLWKERDLRTMDIGLLATMNGRERTLKEWKAIIAEADPRFVLQNVVQPKDSMLAVMEIVWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7V2</accession>
    <name>H1V7V2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf652 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_07903</name>
        <name evidence="7" type="ORF">CH63R_04148</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001920">
        <property type="protein sequence ID" value="CCF36304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160369.1">
        <property type="nucleotide sequence ID" value="XM_018299123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7V2"/>
    <dbReference type="STRING" id="759273.H1V7V2"/>
    <dbReference type="GeneID" id="28863230"/>
    <dbReference type="KEGG" id="chig:CH63R_04148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04148"/>
    <dbReference type="eggNOG" id="KOG3165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081098_0_1_1"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
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    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
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    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF36304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="200" mass="22866" checksum="B0020247BBD77F97" modified="2012-03-21" version="1">MGVQKKTRKFAEVKRVIGKNDVRRKENLKKAEEAVEKAKRERAGPDGNERIREVPQMPSSFFFQANSALVPPYSVIVDTSFWSRTIQMKLEPLETMMDCLYATCQPIVTDCVMAELEKLGPKFRLPLRIAKDERWERHKCTHKGVYADDCIVSKVSKDRVYIVATNDAGLVSRLRRIPGVPIMKCARGKYVIERLPDAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8F9</accession>
    <name>H1V8F9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_00231</name>
        <name evidence="14" type="ORF">CH63R_08108</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002013">
        <property type="protein sequence ID" value="CCF36512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157860.1">
        <property type="nucleotide sequence ID" value="XM_018303082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8F9"/>
    <dbReference type="STRING" id="759273.H1V8F9"/>
    <dbReference type="GeneID" id="28867189"/>
    <dbReference type="KEGG" id="chig:CH63R_08108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08108"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_1_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="119"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="315"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF36512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR09343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="474" mass="51117" checksum="EB01A7F2444C40DF" modified="2012-03-21" version="1">MSDDSANQHFRGQVRSWGTANKPNGRDGDVDENSPLLVNGNHSATHESHVVNGDSGNQTLKFLFNSTHTPGTDSPNVAVRYSSQVWHVTKVSLLSNYVNFLLVMVPLGIVAGKLHWSPTAVFTINFFAIIPLAAVLSFATEQISMKLGEALGGLLNATFGNAVELIVSIVALKEGQIEVVQSSMLGSILSNLLLVMGMCFFFGGIVNMRDRVTGQGMEQSFASATAQTTCSLMTLSSASLVIPATLYSVLDKADSVEKEHSILVLSRGTAIILLLLYVLYLWFQLRTHPNLFDAEIQHHNDEEAEEPIMGPIAAATVLVVTTILVAICADYLVESIDPIVETAHISKNFIGLILIPIVGNAAEHVTAVVVAIRNKMDLAMGVAIGSSIQIALLVTPFLVILGWAVLDKPMTLHFETFETVAFAFSVLVVTYTVQDGKSNYLEGAMLLGLYIIIALAFYVSPSDALDKVLSVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V931</accession>
    <name>H1V931_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_08236</name>
        <name evidence="2" type="ORF">CH63R_11934</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002120">
        <property type="protein sequence ID" value="CCF36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153749.1">
        <property type="nucleotide sequence ID" value="XM_018306908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V931"/>
    <dbReference type="STRING" id="759273.H1V931"/>
    <dbReference type="GeneID" id="28871015"/>
    <dbReference type="KEGG" id="chig:CH63R_11934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11934"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_037990_1_1_1"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
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    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="256" mass="28041" checksum="ED608D06A6C1E698" modified="2012-03-21" version="1">MTSARPQPTSLAELNRVFWDANVDTFWQQDWLKTFVDQLTRFLRTQAPNLGLRPRDPANPVRLLDYACAYGGASWALAPFVDEILGIDIAPAIVGRFNDCAVRLGYSPAQAHAVAGDLTADGSMAAEAGFDVVIISMALHHLEDPKRMMELLAQRVRPGGVLIAVESVSAMETQSEAGNLDGDSLGKFEHEVLKTTNRHVVYSKGLFSGWFEEVGCDKERFLYIENVEVSHIPENIVGKPGGLNRRMVIAASVKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9D8</accession>
    <name>H1V9D8_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Ran-interacting Mog1 protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_08319</name>
        <name evidence="5" type="ORF">CH63R_11906</name>
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    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002176">
        <property type="protein sequence ID" value="CCF36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153721.1">
        <property type="nucleotide sequence ID" value="XM_018306880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9D8"/>
    <dbReference type="STRING" id="759273.H1V9D8"/>
    <dbReference type="GeneID" id="28870987"/>
    <dbReference type="KEGG" id="chig:CH63R_11906"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11906"/>
    <dbReference type="eggNOG" id="KOG3329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081345_1_2_1"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="198" mass="21856" checksum="4B1717373C2BE14E" modified="2012-03-21" version="1">MTRYKSTSLYGGALVSDLPEKFADVSKLREVPDNQEVWIDSDGFTSIIFDITERVGPAGSSPEIDGRAMTTHLEELVGEDIDTVKVWNTTETSFSRLSPDVPAYTLIATQTPHAQSGSKSGSSAPDFTAIILTLLRLEKESTDILVTINVPHIKGEYDEADVDLELGKQGKLIGDAVEYAARIWETFKVKDWTLFQEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-11-27" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAN0</accession>
    <name>PHB2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ChPHB2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PHB2</name>
        <name evidence="7" type="ORF">CH063_08657</name>
        <name evidence="8" type="ORF">CH63R_01101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2022" name="Commun. Biol." volume="5" first="698" last="698">
            <title>Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy.</title>
            <authorList>
                <person name="Yan Y."/>
                <person name="Tang J."/>
                <person name="Yuan Q."/>
                <person name="Liu C."/>
                <person name="Chen X."/>
                <person name="Liu H."/>
                <person name="Huang J."/>
                <person name="Bao C."/>
                <person name="Hsiang T."/>
                <person name="Zheng L."/>
            </authorList>
            <dbReference type="PubMed" id="35835849"/>
            <dbReference type="DOI" id="10.1038/s42003-022-03666-5"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>IDENTIFICATION IN THE PROHIBITIN COMPLEX</scope>
        <scope>INTERACTION WITH ATG24</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins (By similarity). Involved in mitophagy (PubMed:35835849). Required for the switch to necrotrophic growth (PubMed:35835849).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2) (PubMed:35835849). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa (By similarity). Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy (PubMed:35835849).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expressed in hyphae and highly induced during the necrotrophic stage of infection.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Abrogates mitophagy (PubMed:35835849). Defective morphogenesis of mitochondrial cristae; cells are sensitive to menadione (generates reactive oxygen species in the mitochondrion) and the mitochondrial membrane potential is affected (PubMed:35835849). Decreases formation of secondary hyphae (PubMed:35835849). Decreases colony growth and reduces conidial production (PubMed:35835849). Decreases virulence on A.thaliana (PubMed:35835849).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002394">
        <property type="protein sequence ID" value="CCF37283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164438.1">
        <property type="nucleotide sequence ID" value="XM_018296076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAN0"/>
    <dbReference type="SMR" id="H1VAN0"/>
    <dbReference type="STRING" id="759273.H1VAN0"/>
    <dbReference type="EnsemblFungi" id="CCF37283">
        <property type="protein sequence ID" value="CCF37283"/>
        <property type="gene ID" value="CH063_08657"/>
    </dbReference>
    <dbReference type="GeneID" id="28860183"/>
    <dbReference type="KEGG" id="chig:CH63R_01101"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01101"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="PHI-base" id="PHI:123280"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0000353"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000461185" description="Prohibitin-2">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="AIM" evidence="1">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="35835849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="35835849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="35835849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="EMBL" id="CCF37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF37283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <sequence length="311" mass="34076" checksum="EA80D66E114FB21B" modified="2012-03-21" version="1">MSGGRSPMEEAYARLRQVAEQQQKRGGFGGGGLPGGPRGAGMGLAGLVLLGGAAFVAQNALFNVDGGHRAIKYRRTTGVSKEIYAEGTHFVIPWFETPVTYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPDIAALPQIYRTLGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVAKLVRENLSRRAARFNILLDDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFVVDKARQEKQAMVVKAQGEARSAELIGDAIKKSKAYVELKKIENARFIAQQMQESGSKNRLLLDSEGLGLNVFEDREKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCZ6</accession>
    <name>H1VCZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01836</name>
        <name evidence="4" type="ORF">CH63R_11448</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Glomerellaceae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Baculoviral_IAP"/>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <begin position="339"/>
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        </location>
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            <begin position="351"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="393"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="423"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        </location>
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            <begin position="569"/>
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        </location>
    </feature>
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        <location>
            <begin position="605"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <begin position="624"/>
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        </location>
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            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <begin position="674"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
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            <begin position="772"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="852"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38196.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR02428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="922" mass="100653" checksum="4CB904F587C492BF" modified="2012-03-21" version="1">MADNLAFEGLVPNEYFTYEGRLGSFHQVYPAPKRRQSGATKGGSKNLVWPHMKYLAPEELAKAGFVWRPFPDNPDNVACFLCNKSLDGWEEGDKPLEEHLKHSPDCGWAIVAGIEVNLNGLASEDPASTRMIAARKATFDGRWPHEGKRGWKNKIKQLAEAGWKYTPSLEYNDMATCTYCELALDGWEQNDKPMDEHFNRSPDCPYFALVQQHAATRKTKGKGARGSKTTARLSVQSVATAASDITSTSDIAAEYDDSVLTTSSTMAGKKGSRAKKAATTTKTRKTKAKKDEPVEVVENEAMLDEEMPPAPPPKPTRGRKRPSEEVDESALTISEAPAPKKRTARGRGKATTDNSTLEHSQQDISIEDAPPPAKACKGRKTARASGTKGTRKASGTSQRSTASIASLRAAPGAFPGDDDDDEITRQLEADLERPLTDDEDIMQDSDSERKREPASKAKKKKSHSGKDAISPEPRGNQEMFDAEPYVADENDVDEDLKRLEAEMTVNESELLEVPKKGRKAAGTRKVSKQTKAQKAKATKAAVQEDELAATSTEPAKVEEPVAMEVDELSTATVVTKPARSSTGKKRGRPSKASLASRASMEGVPEVEKVEVVEPDHVATVPETENVEAEPESEVETESAETSARQSFASAQQTHAPAEQQDELAGSPGEREEHDTLEEPELPEEIEEPEEVEEIEDVKDVEEADEVEEEPEEESEPELENGDDNDAEPELEAPEPTPKSAPKESSPAHPSSPVVASSTRRSLRHQQGTTRISPAQSARQAAVSPSPSPQSSDAENQPPSSRPSTSQKRVTHAPTSSIPARPSSPTKRKALASLQSTTPWNPVDIDLIFGSPEKNDKRNPVDRLLHKGSELTSPEKRMTVEEWIHHNANQAEAKLRQECETMVSKFESEGSKAMNVLEGLIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFJ5</accession>
    <name>H1VFJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fms interacting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_09948</name>
        <name evidence="5" type="ORF">CH63R_01067</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003256">
        <property type="protein sequence ID" value="CCF38998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164404.1">
        <property type="nucleotide sequence ID" value="XM_018296042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFJ5"/>
    <dbReference type="STRING" id="759273.H1VFJ5"/>
    <dbReference type="GeneID" id="28860149"/>
    <dbReference type="KEGG" id="chig:CH63R_01067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01067"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082754_0_0_1"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="24185" checksum="DBFFF7C36EA4049E" modified="2012-03-21" version="1">MAVNDLVSDKKLGAVLQTSGDAQNQALKLLQLLSDIARAEETGGAVEQLQATLSKEQKLLLTNISQLRGLHRSANFDARDTKAQTAEARHEVDRLHLQLQNLYYEQRHLEGEIDACGSYDHTYQKLSLIPVESFVALHPEHADDDENAMMVARIGHERAEREALEQQRLELVGRKQKLIADNKKRKDDLANLDKDLEKFIDAAKPIQELFEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK86</accession>
    <name>H1VK86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_11155</name>
        <name evidence="2" type="ORF">CH63R_12807</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
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                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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    </evidence>
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    <sequence length="77" mass="7746" checksum="D15F3DE1CFD5AE33" modified="2012-03-21" version="1">MQGGCHADGYGYAEVVVGAGEVGPFQHGERLESLAPHQGVGALDALIAGKEVVALGPQPVVRGLAPPVDGEQDTCVP</sequence>
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    <accession>H1VL76</accession>
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            <fullName evidence="4">Allergen asp f4-like protein</fullName>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Glomerellaceae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004418">
        <property type="protein sequence ID" value="CCF40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018151965.1">
        <property type="nucleotide sequence ID" value="XM_018307548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL76"/>
    <dbReference type="GeneID" id="28871655"/>
    <dbReference type="KEGG" id="chig:CH63R_12574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12574"/>
    <dbReference type="eggNOG" id="ENOG502SN6Y">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
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        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
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        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">IMI 349063</strain>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="CACQ02004624">
        <property type="protein sequence ID" value="CCF41318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162706.1">
        <property type="nucleotide sequence ID" value="XM_018297890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VM65"/>
    <dbReference type="STRING" id="759273.H1VM65"/>
    <dbReference type="GeneID" id="28861997"/>
    <dbReference type="KEGG" id="chig:CH63R_02915"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02915"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_0_1_1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011939331" description="Carbonic anhydrase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="11">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF41318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="289" mass="31780" checksum="5B6326266261F763" modified="2012-03-21" version="1">MKSSLLLPFATLASAICHHRTSLYARSHGLTARDEGGVDVATFDYNDLTGPLNWHAHSNQSIKCATGTQQSPINLNDTSATLVPGTSLGFDVPDLLDGAEFENLGSTLEVVAQNGTLTRHGRKFHLKQFHFHTPSEHRVESEYFPMEVHFVFEADAEQLKNSSGPSNSVLGFLIEVDNSAPSSFLKNVFAHLDEVEEPGSHAETGPLSFCELRTVLEHSDVYQYDGSLTTPPCSEGIAWNVVAEPLRVDDVTYRAAKKIMKFNARYTQNVPGQRNLLEHSRITLNAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VN61</accession>
    <name>H1VN61_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_11878</name>
        <name evidence="5" type="ORF">CH63R_14346</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004843">
        <property type="protein sequence ID" value="CCF41665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151638.1">
        <property type="nucleotide sequence ID" value="XM_018309320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VN61"/>
    <dbReference type="STRING" id="759273.H1VN61"/>
    <dbReference type="GeneID" id="28873427"/>
    <dbReference type="KEGG" id="chig:CH63R_14346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14346"/>
    <dbReference type="HOGENOM" id="CLU_2654367_0_0_1"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF41665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="76" mass="8060" checksum="15F8C20AD02D6B4E" modified="2012-03-21" version="1">MAAKKEILVIGGTGAQGAPVVRALAESGRYTVRVLARKIESSRAKDLAALVNVALIQGQQTNQQDLHRAFRGVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VR42</accession>
    <name>H1VR42_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02898</name>
        <name evidence="5" type="ORF">CH63R_13591</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005579">
        <property type="protein sequence ID" value="CCF42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150883.1">
        <property type="nucleotide sequence ID" value="XM_018308565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VR42"/>
    <dbReference type="STRING" id="759273.H1VR42"/>
    <dbReference type="GeneID" id="28872672"/>
    <dbReference type="KEGG" id="chig:CH63R_13591"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13591"/>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_0_0_1"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="175" mass="18743" checksum="C0C853B2DE7C88A6" modified="2012-03-21" version="1">MASTIFRSLFAPAMRPATFPRAASLLTPTAAPFIRSFSSTPVQNATIMQVLRGCHKKGKRARHAVSPALSDINAPALKGVCLKVGVVRPKKPNSGQRKTARVRLSNGRHVTAYIPGEGHNIQQHSVVLVRGGRSQDCPGVRYHLVRGALDLGGVANRVSSRSKYGTMKPKKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VR64</accession>
    <name>H1VR64_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_12639</name>
        <name evidence="15" type="ORF">CH63R_02113</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CACQ02005596">
        <property type="protein sequence ID" value="CCF42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161904.1">
        <property type="nucleotide sequence ID" value="XM_018297088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VR64"/>
    <dbReference type="STRING" id="759273.H1VR64"/>
    <dbReference type="GeneID" id="28861195"/>
    <dbReference type="KEGG" id="chig:CH63R_02113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02113"/>
    <dbReference type="eggNOG" id="ENOG502SM0W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041038_1_0_1"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:hydrogen peroxide catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to reactive oxygen species"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ccp1-like"/>
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        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010395790" description="Peroxidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="121"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="97"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="410" mass="44567" checksum="5F86698BBAA81A4D" modified="2012-03-21" version="1">MHLTSLLATSMALAAVPGAMAYPGMGQQIEDIKARASDRGDSNELLGDLISLQDRQLTAVGKDVKRILQGKGDPESNDRYILKVPDLTSDKCKKDTCCVWRYVADDMYQFMAGKSGRCTGLARAAVRLGFHDAGTWSKATASQGGGADGSILLAPGEIDRFENRGLQEVAAKFIELRGKYLSMGWNIGMGDFIQMGANVATVVCPLGPRIKTYVGRKDSAVGAPRGLLPSPFQPADQLIQLFRDKTIGPHGLVALLGAHTTSQQNFVNTTRAGDPQDSTPGVWDVLYYKETLSTNSPPRVFKFPSDIAISQHPETAKEFQDFAGRGGQDHWNEDYAREYIRLSLLGVDNINQLVECTKVLPPAIKGFRILDQFKLDKWLNSVGNKGAAKKVAQDIEKGDPASVEVPPVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRV3</accession>
    <name>H1VRV3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf833 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_02961</name>
        <name evidence="2" type="ORF">CH63R_06698</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005767">
        <property type="protein sequence ID" value="CCF42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159523.1">
        <property type="nucleotide sequence ID" value="XM_018301673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRV3"/>
    <dbReference type="GeneID" id="28865780"/>
    <dbReference type="KEGG" id="chig:CH63R_06698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06698"/>
    <dbReference type="eggNOG" id="KOG2342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047037_0_2_1"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="353" mass="38975" checksum="FD2C706B3C09D6F9" modified="2012-03-21" version="1">MCIVLLTTAHPDYALIVIDNRDEFILRPTSRPHWWSHPSGASVLSARDLQRAEKGTWLGITKTGQLAVLTNYRETNTQDVTHPIHAARSRGGMVTTWLGSDPTEPASESVNHLVKDGGVKGVGGFSMVAGKLKRKRGDGDDEKPQRALEGIAIISNRCDDLEDVPWIAEKRGEVYGLSNTGYDDPKPWPKVENGKRLVKETIQKAVAEGLGENALAERLFEVLDTDSLPKHPDMSLADYIKELKQSIFVPALGDDAHRKAMEEAVSRGPGHWATDDQKAAEGLQLGERPDPPAQASMGFEVGLYGTQRQTVIMVDWDGNVTYRERALWDGNGNPIERGQGDEVFKFKIEGWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSR9</accession>
    <name>H1VSR9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxin 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_03033</name>
        <name evidence="11" type="ORF">CH63R_03055</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005979">
        <property type="protein sequence ID" value="CCF43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162846.1">
        <property type="nucleotide sequence ID" value="XM_018298030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSR9"/>
    <dbReference type="STRING" id="759273.H1VSR9"/>
    <dbReference type="GeneID" id="28862137"/>
    <dbReference type="KEGG" id="chig:CH63R_03055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03055"/>
    <dbReference type="eggNOG" id="KOG3756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049352_2_0_1"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="99"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="34558" checksum="1E9E30B0AE770E54" modified="2012-03-21" version="1">MATVTEYGARSSLEPDEKLTEPRAPADTVKTETTSSEIDVTQKRKASPDSFEGEDPFKRPKIEERDPPTQDSALSTDSRPRDQGADTNAPRRAPLSKDEEKKRGKRLFGGLLSTLSQTNASSQHKRRREIEQRQHERAQKQRAEDDKRRTEKLARITEARWREQIKLDEKAMKTRHVNMLAMAHSLRSKAKPPVYYRPWKLTSEQEDRIDGQIEDARVVIAREVEAFRGRKEEHRRRYGQTSPARDEVSAPVVMDDAAKANTEPLLVEAPTHAPTVANEVPSSHHQHDEPGDVVEDAEDMVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTM7</accession>
    <name>H1VTM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_13244</name>
        <name evidence="3" type="ORF">CH63R_13068</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
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                <person name="Will I."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <strain evidence="4">IMI 349063</strain>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
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                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Law A.D."/>
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                <person name="Prusky D."/>
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                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008190">
        <property type="protein sequence ID" value="CCF45941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157489.1">
        <property type="nucleotide sequence ID" value="XM_018302711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W0C9"/>
    <dbReference type="GeneID" id="28866818"/>
    <dbReference type="KEGG" id="chig:CH63R_07737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07737"/>
    <dbReference type="HOGENOM" id="CLU_1440966_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="188" mass="20168" checksum="F0B5F968EDB522EB" modified="2012-03-21" version="1">MNVSQAISPDATTEAGRSDGRDDQARYGPPNGPTVSSAVAPALLSDTREQAHSPWPRGPSAYRPWVIVFVPASAVIASSGYTRTMGQARSTSAMLSVYCRSMSIAEGWPWDGNATTALCGSWAASSSRHSKGRAGKGYWRRLDRHLFFYRSPSTALMAGDPAERISRIEGSGPVEHHQTVACARSPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3S3</accession>
    <name>H1W3S3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04061</name>
        <name evidence="8" type="ORF">CH63R_01129</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009401">
        <property type="protein sequence ID" value="CCF47136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164466.1">
        <property type="nucleotide sequence ID" value="XM_018296104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3S3"/>
    <dbReference type="STRING" id="759273.H1W3S3"/>
    <dbReference type="GeneID" id="28860211"/>
    <dbReference type="KEGG" id="chig:CH63R_01129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01129"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF47136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="393" mass="44140" checksum="F7E1709B5C839738" modified="2012-03-21" version="1">MSTRYALVSLPLGIFDSSDKEDAIASLNATISPENGSVRPFNIPDFKIGTLDALVQQADDLAKLESTCEAVVAKVADSLKSILDGDEDKISQQKMVNDKPTDQYVSSFSWNRVRYRADKPLSELVDTLQKELITTDNDVKSKFNQYNSVKTNFATLQRKQTGNLATKSLTPVVDPALLIQHSEYLETHLIVVPNNAKKDFLRSYETLAPMVVPRSAVQVASDEEFTLFAVTAFKKHSAEFLQKCREQKWTPRQYKYVEGGKEEEQRELDRVAREEKKTWGEALRIGRTGWSESVMIWLHVLALRVFVEAVLRYGLPLDYVSVLIKTNSKLVKKVKTALDSNYSYLGGNAFGRDKRGKITKDDATLSSEMAAAGLGGGEGHEYTAYVYYEFDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQU7</accession>
    <name>A0A1B7XQU7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150654.1">
        <property type="nucleotide sequence ID" value="XM_018309411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQU7"/>
    <dbReference type="GeneID" id="28873518"/>
    <dbReference type="KEGG" id="chig:CH63R_14437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14437"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="172" mass="19691" checksum="801C67F3FE55CDFF" modified="2016-11-02" version="1">MVDYCMLVDCPVLLPDEPSLDDAIRRTRNLSGRDTLNHTPSFLLRDKPISLSIECKKRDRGLDNADLQISSWHAAQWRYLLMLCRKTGADVSGLPFLPGLIVSGAEWYFVATTRAGNKTTLWTRRCIGATTNVVGTYQIIRTIQYFSWWTQTVYWPWFQEKVLGLVEADDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQZ1</accession>
    <name>A0A1B7XQZ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150689.1">
        <property type="nucleotide sequence ID" value="XM_018309446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQZ1"/>
    <dbReference type="GeneID" id="28873553"/>
    <dbReference type="KEGG" id="chig:CH63R_14472"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14472"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="443"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="669" mass="76879" checksum="32239BEC33FE4789" modified="2016-11-02" version="1">MLAQALSLTTATVVFYLLLRTILARNRSTLRCNRKPPSAQTRLPADRASRGVRVCQVYPTNSNVETDIDIIAVHGLDTNSPETWEDRSKGKPTVNWLADEGMLPHEVPHARIFTCDWPADLFRDPNVEENRIDELARLLLEGILGRPQPTDKQLRNRPILFIASCLGGIVLMKALEMAYDKYLPVQEATCGVIFLATPFSGTSFEKVAGWAEPGLRTWASFRGQGVTQLLDWVNGDHFDLDELVRRFTALYQKKAYKVHTFYENGFTDLSRKVPLLSFLFPSEKTQLVNKRSATLPTVQHPLPLERNHVRMNKFRGPKDSDPDYKLVVDQIRHCLEEIRKGTPLERADAWIRNEHYTEQKLKIERLSGDPLRMDQCYINLALVELQRADSSERRSEEPALRSSPFSLSDRLKIETPHKDIQVKLEALFDPRKMPDGHVKPPQRILIRGRAGVGKTTLCKKIVYDFTHGTLWHDKFDRLLWIPLRNLKREARTNVPGYNMGDLFRHEYFSTPEATDLIDALWKETYSALAAIVSRIHASHEMHLHAAVDTERLHREGLRRRKEEFASYREAVRLISRRPVPSVLCTISQGEKEILASFASTAKAIDAFVEEKQPAPSSSDDLWDSHQEHHRNHEISRLYRICVVHILILRYAVAKFHRQAEVQEERALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS65</accession>
    <name>A0A1B7XS65_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151117.1">
        <property type="nucleotide sequence ID" value="XM_018308799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS65"/>
    <dbReference type="GeneID" id="28872906"/>
    <dbReference type="KEGG" id="chig:CH63R_13825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13825"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="428" mass="48792" checksum="93AE96C652A4C858" modified="2016-11-02" version="1">MGVSVLESSSSMTSSIMQYREENGRTYHAFREGRYVLPNDAVENDRLGEAHKLKEVAKVFHRVLTIEAIQTSNIIYALSPLMRSYSSVRRARRSRFAEFLMPAPALASGPWILVITTTFNPGSQATDERADTFFRRQPTSTQRHWSPALTSVRYSHYCKTSKQSVLFMTYFQKTKLSVPPNVTFYIDDLEDDWTYSYKFDFVYGRMLTGSIADWPRFIHQSYEFLEPGGWIELTDILLDLQSDDGTVGPDCAAQRWAVHMREAAAIWKRPLDSCMFYKQQLAEAGFTNVTERVYKWPSNPWPKDGKFKELGQLTRGVPRHVDVRELRSRLVRAEPGPVHEGAGVVEGATGSVSGRCEKGHERQVDTWLVADVSRVAPPLPLFVFLPPSEKKTAERFLVDTSSTRRNQNEQLLDTGDTWGERQVNGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTU8</accession>
    <name>A0A1B7XTU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NupC family nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151696.1">
        <property type="nucleotide sequence ID" value="XM_018307279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTU8"/>
    <dbReference type="GeneID" id="28871386"/>
    <dbReference type="KEGG" id="chig:CH63R_12305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12305"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="421"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="641" mass="70400" checksum="799E882EE90A92AC" modified="2016-11-02" version="1">MASQVTEVNQTNTTGATGGTPLRRDSDPALDIHNQQHHHHHPGAVDAKGHGDNVTYVPTDVSTVPQHADAPHDIEKGEKLSGPPDYDGEKAAVVSSNDEEEEEPQRRSIFASITRWWKRIYKEHRFLVQSKVMFYITAWWVASLVLHRNDKNWIVPFLVWFGCFLRYVFNFVPSSYASRPIKFAWHHSAVYIYNFIPAKYRTLAGGALTLAVIIVGTFASEEVADNTHENRAVSIFGLVFFLFCFWLTSHDRKRINWRPVIGGMLSQYIIALFVLRTSVGYDIFKFIADRAGDLLGFANQGTIFLTAESVIDLHWFISGVIPPIIFFVALVQLMYHVGFLQWFIGKFATFVFWALEVSGAEAVVAAATPFIGQGESAMLVRPFVPHMTKAEIHQIMTCGFATISGSVLVAYINLGLNAQAMVSSCVMSIPASIAISKLRYPENEETLTAGKVVIPPDDEHEAKNAIHAFANGAWLGIKIAGTIIACLLCILAFIALIDALLTWVGSYIQIKELTINFITGYIFVPLAFFLGVPRDGDLLKVARLIALKVVANEYVAFSAMKEPEYLDLSPRSQLIATYALCGFGNISSLGIQIGILSQLAPSRGGDVSALAVSALFSGVIATLTSAAVAGLVVTHQTTQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUA0</accession>
    <name>A0A1B7XUA0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151822.1">
        <property type="nucleotide sequence ID" value="XM_018307405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUA0"/>
    <dbReference type="GeneID" id="28871512"/>
    <dbReference type="KEGG" id="chig:CH63R_12431"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12431"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="107" mass="11616" checksum="92FB9025824285F9" modified="2016-11-02" version="1">MHPPPNEPDPECRPHHHETPKTPPDTTIGYLASNDSAGDRTSSPPTANWLSDSTSRGQGHGEEGVLVNGLLLSRLPALLMYASFLHPANAYPIQQATEQAVRVRREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUS3</accession>
    <name>A0A1B7XUS3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Plasma membrane ATPase</fullName>
            <ecNumber evidence="4 18">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH63R_12646</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cell membrane</location>
            <topology evidence="2 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="4 18"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152037.1">
        <property type="nucleotide sequence ID" value="XM_018307620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUS3"/>
    <dbReference type="SMR" id="A0A1B7XUS3"/>
    <dbReference type="GeneID" id="28871727"/>
    <dbReference type="KEGG" id="chig:CH63R_12646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12646"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="856"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="71"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR03519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="923" mass="100153" checksum="76E2DBA5DD8956AB" modified="2016-11-02" version="1">MADSNATAAPALSTPIESHKFDEKERPLDAPANPKAEVDEEDDEDIDALIEDLESQDGHIDEEEEEDGTPGMGRVVPEEQLQTDTRLGLTEQEVLNRRRKWGRNEMAEQKENLILKFFMFFVGPIQFVMEAAAVLAAGLEDWVDFGVICGLLLLNAVVGFVQEFQAGSIVAELKKTLALKAVVLRDGTLKEIEAPEVVPGDILQVEEGTIIPADGRIVTEDAFLQVDQSAITGESLAVDKHRDDNCYASSAVKRGEAFVIVTATGDNTFVGRAAALVNAASAGSGHFTEVLNGIGTILLVLVIFTLLIVWVSSFYRSKGIVDILRFTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLAEPYTVAGVDPEDLMLTACLAASRKKKGMDAIDKAFLKSLRYYPRAKSVLSKYKVLEFFPFDPVSKKVTALVESPAGERITCVKGAPLFVLKTVEQDHEIPEEIDQAYKNKVAEFATRGFRSLGVARKRGDHGAWEILGIMPCSDPPRHDTARTVNEAKSLGLSIKMLTGDAVGIARETSRQLGLGTNIYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIFLGLWIAILDTSLNIELVVFIAIFADIATLAIAYDNAPFSKSPVKWNLPKLWGMSVLLGIVLAVGTWITVTTMYAHGGPDGGIVQNYGNLDEVVFLQISLTENWLIFITRANGPFWSSLPSWQLAGAILVVDILATCFTIWGWFEDSPTNIVAVVRIWIFSFGVFCVCAGVYYLLQDSAGFDNLMHGKSPKGSQKQRSLEDFVVSMQRVSTQHEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVA4</accession>
    <name>A0A1B7XVA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Intracellular protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152225.1">
        <property type="nucleotide sequence ID" value="XM_018307808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVA4"/>
    <dbReference type="GeneID" id="28871915"/>
    <dbReference type="KEGG" id="chig:CH63R_12834"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12834"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="4">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="5">
        <location>
            <begin position="421"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="552" mass="62949" checksum="EF200F1464A9F553" modified="2016-11-02" version="1">MLHLVFDNSEAKNMAMAVTEGDEKNGEEVVTSIQTVAAHLISGLNREQDSRVVVGYLMLLLGWLFEDLDAVNDFLGEGSNTQSLIQAVNHPYPSGDVVQGLCAMLLGVLYEFSTKDSPIPRADLHNILLSRMGRERYIDKMSKLRSDPLIRDFEVTPQKLGNLGSGKLPDVYFDATFVDFLKDNYSRILRSIDRDPGLEISVVSNGIQKGVSRELVDSLRAQLTEKDQALQEAQVRVETIGRQLGQEQADHRRTRETTAMELARIKQVNEGMQRQHDAELRNLQSRVTSLQEEHQKQDEQTRRKTESLVATLEQQHKKQLDEAQRKADAHVAALEQQHKRRLEEVQRDATSRVTALEQELRKQIDQAQEIAKTQAASQLEEHRKQLEQARKTAESDADRVRHRAEADMADLKATISRLEVDLMKAKKTKLQEIQAVREELEEKAREQETLVVKLEANAKQLEKDLRETREKAMQDDMAAKKAEEDRKTTQNELDDLLMVFGDLEEKVAKYKAKLRELGETVSDGEDEDEDSDEEEERDEDDEKDEAKSDDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVI8</accession>
    <name>A0A1B7XVI8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152320.1">
        <property type="nucleotide sequence ID" value="XM_018307903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVI8"/>
    <dbReference type="GeneID" id="28872010"/>
    <dbReference type="KEGG" id="chig:CH63R_12929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12929"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="172" mass="18696" checksum="52B4348BD7273989" modified="2016-11-02" version="1">MADNDMEMTHAEMWDDSALIDSWNEALDEYKASGPLPSHERRWFPSTLDAQPQAVDQLEIVPGTEGASKTEEAGSSTEVKQPLDPSGNPGRSEKLGSVLMHLVQNDSSDVPIAKAVSGHGDNGLGPATMGPQSLLGTVQDEGLKKLLMSWYYAGYYTGLYEGQQQQQQQQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVM5</accession>
    <name>A0A1B7XVM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich Repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152316.1">
        <property type="nucleotide sequence ID" value="XM_018307899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVM5"/>
    <dbReference type="GeneID" id="28872006"/>
    <dbReference type="KEGG" id="chig:CH63R_12925"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12925"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="641" mass="71479" checksum="8D7BE6C6CFC2E068" modified="2016-11-02" version="1">MAAPRPPLQPHTSSQDHTPPGAPPTGHNISQTQTKYKMDSPEPHRPATPEKNGRSSFSSIRENDSDLAQTFTSSKVSSYAQKVTSAVFDDSSASPSPVASPSLEMGEVQFMPPVTLPSSRLHGGWYPASSFKGWKQINVKGKTASRSFSDLQALHMAWSTPPAPSQGNNKFSNGRAPMERLPLEMLGSIIELLVLDIPPPYGTARRNVDLMSLLLTSRSIHAATLNTLYKHITIPHSRIFRKFLSNITTHPALGTIVRRIDFSHFNNATLFESASERKGTRNLTAETLVQCLELTPHLQEFLAMEHIDDDLGAEVLQKLFFDMPRLQALDFAGCTSPAFKNSFASLVDMAWPQTLSITRLSFHKCLTLPSALFEEVLPRLANVTHLDLAQTKITDRALQSIPKTAKITHLNIAKCTLLTASNVIDFLATHPAVRNLVYLSVATDARSHQLLDVEDVSQLIPVLPKTLKSLSLKGSRMDDAHIELLRPLTKSLEELAVGRNMDVNAAAKLLEPADEKKQEEPHTLRYLDLSDLWGNELDIVDLFSSRNSLLRPSSVPLEVVEISEQSFKSLSRNRTLERIGWSLQEIGSRCWMVRLQDHRKDQDRGYRWWKMGADNWGMRKIPVARAEVGGMYGSFMFGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW41</accession>
    <name>A0A1B7XW41_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152483.1">
        <property type="nucleotide sequence ID" value="XM_018308066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW41"/>
    <dbReference type="GeneID" id="28872173"/>
    <dbReference type="KEGG" id="chig:CH63R_13092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13092"/>
    <dbReference type="OrthoDB" id="4846259at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="29337" checksum="7E92C38A8BCA41F2" modified="2016-11-02" version="1">MAVAEETPAAVRVTEDEIAKPDDRPGAAAEQADITRPIGAQPCSTKTGDVVLRVEEDGDDVAPKLQRDDGAPDEDDDGPPRRRSTAGSGTNWLLLLASFLSSYSMYTFQEGIPEEDMIPLDHLLKRVIGPLWDPSPAVLALVVIVLAASTSAVVYRQGMSWVTTLGLGSAFSHFPVGVWREGWRETALRDAPMRLMIPPLLLQLVRAVEARTGWDITRERSIREGREERRAEESGDREALEMREGDGSGGDGVGGLLDQDRRREGYGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWI6</accession>
    <name>A0A1B7XWI6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152644.1">
        <property type="nucleotide sequence ID" value="XM_018308227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWI6"/>
    <dbReference type="GeneID" id="28872334"/>
    <dbReference type="KEGG" id="chig:CH63R_13253"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13253"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="229" mass="26732" checksum="56D2A0B10D4F8520" modified="2016-11-02" version="1">MEKEVLLTEDPRTDPISQRSSYHDETDSANYTVEVLSKRKARHGRIWSTIAKMALIPAAVVIFYLGRATHDMTPGYPPEPVSLGKCSPDWKVSKARGCVYDFVLSTWMHPRCFNEDMHERYLGYMKWRNTTFWYERERINEVPFDVAAKGEHGEIFTDGTVHHMHCSYVWDRITYASHFNPRVLDSLCRDPKHVEHCILYNGIPQSWEIDLPNITRVYNEPHEVDCLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXP1</accession>
    <name>A0A1B7XXP1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153061.1">
        <property type="nucleotide sequence ID" value="XM_018306220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXP1"/>
    <dbReference type="GeneID" id="28870327"/>
    <dbReference type="KEGG" id="chig:CH63R_11246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11246"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="425" mass="46465" checksum="572908D2D154802B" modified="2016-11-02" version="1">MTTAVPQEPMCLLQRICKVASTPATTPTSAGSKPSYPPVSSIPRTSPSRLAAASPDAPSSPGDNADKDEDAAAQSTVLYLAYGSNLSAETFLGTRGIRPLSRVNVSAPSLTLVFDLPGLPYREPCFANSAPRKVPKLPDPSDPPKLPPVPPLPPPTSSACQSGSSVDLGWDKGLFGVVYEVTPEDYATIVATEGGGSSYADILTPCIPLPPRVSVPEKPPIDIPRPFLAHTLYYPDIPDAPDDDDDKDDDKDDPKKPQDPRKKWYWRFIRPNRRPDPAYAQPSARYLKLITDGAAEHELPDDYQRWLGGLRAYAPTTWRQRAGRWLLTALFLPVLLLFFLLSKRAANKEGKAPLWLGVTLGVIFHLLWTAYDGVLKPVFGDGERTQEEEEEEDGGGGGGTFRKKSWMGRFACTDEEKEGLLEHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYE5</accession>
    <name>A0A1B7XYE5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153287.1">
        <property type="nucleotide sequence ID" value="XM_018306446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYE5"/>
    <dbReference type="GeneID" id="28870553"/>
    <dbReference type="KEGG" id="chig:CH63R_11472"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11472"/>
    <dbReference type="OrthoDB" id="3630276at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601180" evidence="3">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="286" mass="30163" checksum="1E4F02B03DA449E5" modified="2016-11-02" version="1">MRPSHSAPAFVALLCATVASALSPAKLHCLRSRSLELAKLAACGEPGSVAHCLDMLPDELTQTDLEKCYMHAGCEVAEAIIESQWTLDRCGDDGNMPAELRKRHAPVFARQTTAAETTVAAATGTATGTGTRSLIICSTTTTKSTTLCPVVSTGVQRGRTLKEGCYPTQVSFATCAAGLLCKDDPAGKPSCLVLDNTVYPGGVAVALFFAVVITGAIAWITFLCCREKKQKKRIAARAEAAAIARQNIKQRPTVQVGNADSQPLMTHGQPAAGYDAQGPFGDQHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYJ9</accession>
    <name>A0A1B7XYJ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rieske domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153371.1">
        <property type="nucleotide sequence ID" value="XM_018306530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYJ9"/>
    <dbReference type="GeneID" id="28870637"/>
    <dbReference type="KEGG" id="chig:CH63R_11556"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11556"/>
    <dbReference type="OrthoDB" id="4794156at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="221" mass="24061" checksum="2C69FC70663E0E96" modified="2016-11-02" version="1">MSQVVELSWLPVKQDFETSSAIASINELQQKVNVQSDLLGQWEGVQPPNGLDRQPVKAVHLAAVWKSVEAAEATKQSPEAQEVRKAYGQVIDISSALPWTAYFDLAGGDFDKVASANVVFLAGSYLPADVNTAAFYQKWQDLVSSGGVTSGFVAGAHGWSVGHVDYKGEKKKVFMVVTGWDSKESCQAATGGDKRAKFAEALKEFDIQETEHACEHLRKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ85</accession>
    <name>A0A1B7XZ85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP-type transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153578.1">
        <property type="nucleotide sequence ID" value="XM_018306737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ85"/>
    <dbReference type="GeneID" id="28870844"/>
    <dbReference type="KEGG" id="chig:CH63R_11763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11763"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="249" mass="27100" checksum="37864A7FE03C2C62" modified="2016-11-02" version="1">MTSSLSPDQYGKQPSQGQYGGGSGGGGGSGSDQERGPLSSLNLGFLKSLTEKRTTRDGQPPKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEDEVLRLKEIFSNISQDKDKIAEENRQLKQLLVQNGIPLSHYGDDMVSNPSVGYTSSASQSGHSYGQNAYTPPLTSTTAPSVSPSSHGPSHPHSHGQPPPLPQMGSQQLQNRQHGQSSGRGVDFEQAGIDFVLTYDNHHPSKAYLSPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0Z4</accession>
    <name>A0A1B7Y0Z4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154191.1">
        <property type="nucleotide sequence ID" value="XM_018304767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0Z4"/>
    <dbReference type="GeneID" id="28868874"/>
    <dbReference type="KEGG" id="chig:CH63R_09793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09793"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="149" mass="15785" checksum="A7224F38553B1E50" modified="2016-11-02" version="1">MGVGTLGPLAPWAGNAPPMTILSTFWSRGGTEDGDPVDQNVTTNRWPLKFPEFTTCTDGLPPPVLLSSTPARLYRNLDKSAHTRDPDSEPPCANAAAAGLCLVAAMLITRTVVGVFDDDAVQYIFSHAQQLSLEGDVVHSSDDLSGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1D8</accession>
    <name>A0A1B7Y1D8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154344.1">
        <property type="nucleotide sequence ID" value="XM_018304920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1D8"/>
    <dbReference type="GeneID" id="28869027"/>
    <dbReference type="KEGG" id="chig:CH63R_09946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09946"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="415"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="543" mass="60515" checksum="57829EC1BDB453D1" modified="2016-11-02" version="1">MSSPPLRTPLTTRLAAVAGADDDDPLFSSALEETTTPHRRLPSIDPPSSRTSLRTPSNNPLRSSLRSSAHRGLSASGRRSLAANTTPHARAAYRTIDARRAAALTPGKNKRRESFRPRRESLHDVLRGLSRVVKANTQPISSSSSPSDLGSRAPSASLPIRTVGGDRRSLAYDDDDDDDDELPIDRPRLSLPLDVEDEDEDDLVAPELSQIDENATIEFPRRAYTDQVSRMSMGSVRLSEYRNYDDLDDDNDEGGEGFFPGFEVGALDEESGRDREESFGRDEEENLRRQTMASARASDFGFEVPVDADNQTTFVMAVEGQSSPARPLPEVTDEQPSLNITPAYDESVFDELNPPMDEDMGFGGAYDDLRSSTPIEPAEATELDDDETKASAHFEQQQQQRSRKTKRGVKLSRYNVEYPSLPPAVVKRLANTFARSSGISKTKISPEALAEIQRASDWFFEQLGDDLSAYARHAKRKTIDESDMLTLMRRQRQTNQTTTPFSLAHRYLPRELLQELRMPKPPPPAEPRRKRHRVTDGDDGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1P9</accession>
    <name>A0A1B7Y1P9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154425.1">
        <property type="nucleotide sequence ID" value="XM_018305001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1P9"/>
    <dbReference type="GeneID" id="28869108"/>
    <dbReference type="KEGG" id="chig:CH63R_10027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10027"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="242" mass="27456" checksum="3983CC7FEA4E019A" modified="2016-11-02" version="1">MPLPSHNNDHNPPSFGLPTAAPVLEYICLFTHDLKRKQKRWQDGRLKFHTFNKRIMVYDEKGNFIGDMHWREDMDFGEGEELNLERGAVIVQVAECVGSKDQDLTALLDKRAREVEQRHARSSTAAADSPLPTMRLSAVSQNHPQAQFRQRHLADVFNTPRGPQGRASIPTTSPYDERIAAQQTSSPLDENQRPAKRRKRDLSPPSKFGYAQNLFGATLNLSSWTAIAPKWQTIEAANFYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2C5</accession>
    <name>A0A1B7Y2C5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154665.1">
        <property type="nucleotide sequence ID" value="XM_018305241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2C5"/>
    <dbReference type="GeneID" id="28869348"/>
    <dbReference type="KEGG" id="chig:CH63R_10267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10267"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="64" mass="7087" checksum="C50D6F5D169A6B52" modified="2016-11-02" version="1">MAKYVPHLLEIEISEAGPAGPVLEVPGSRYKTRKWSSVSGGKRLAAWRCPQRNSEEIQPEPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2P2</accession>
    <name>A0A1B7Y2P2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_10402</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154800.1">
        <property type="nucleotide sequence ID" value="XM_018305376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2P2"/>
    <dbReference type="GeneID" id="28869483"/>
    <dbReference type="KEGG" id="chig:CH63R_10402"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10402"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR06282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="340" mass="37174" checksum="A3B7213F40071755" modified="2016-11-02" version="1">MGDMTNDIKLLKGSSHGELSEKVAQRGKMGKKLVLTRECADYRLGIPLAKTMSEPGNINDGLMELLIMIHACRTASARRITAVIPCFPYARQDKKDKSRAPISAKLVANMLQVSGCVSFGSFARRRRQGRKDNTNRHVTDAREQNHVITMDLHASQIQGFFNIPVDNLYAEPSVLQWIRSNMNVEDCVIVSPDAGGAKRATGIADRLETGFALIHKERPRPNVVGRMILVGDVTDKIAILVDDMADTCGTLAKAAETLETGGAREVIAIVTHGVLSGNAVETLNKSCLSRIVVTNTVPLGDKIERCPKLRVIDISQVLGEAIRRTHNGESVSYLFNHVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2S6</accession>
    <name>A0A1B7Y2S6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154830.1">
        <property type="nucleotide sequence ID" value="XM_018305406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2S6"/>
    <dbReference type="GeneID" id="28869513"/>
    <dbReference type="KEGG" id="chig:CH63R_10432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10432"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="371" mass="39651" checksum="73243C90B48DA3D4" modified="2016-11-02" version="1">MDNNSAQDGPAPDSNPRALAMFPGKGLATKNVRCGEATAGTGFVLLIAEGKGRKLARSNWGFTNAEKHASACAAHSNSTAGGLAGFQAGGSAQTENGRLHVDDGQDRLLPLPVCFGSDISHGLISTLAEVHTAWAYRACHARAQERARISSASAHMVFERLDTVHMTEGNNIKRSKTRKTSIKIPDAKSNEGIFRTSPRRAIVTHAVSTQCTVYGTRQRGKGARHADPSRSSFVPGPAWRAPPQPASCLWALVVVNTRPRWAMAHRHPSGSGPPPISGCRRTGAALFESFSALGRRFFCPASQGKIAAARPSSRPAGTPRQCTHENRQTLCTNFVPTLPDCCSLSPPDAEPESLFFDGESYLRCIDDAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y354</accession>
    <name>A0A1B7Y354_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_10525</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154923.1">
        <property type="nucleotide sequence ID" value="XM_018305499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y354"/>
    <dbReference type="GeneID" id="28869606"/>
    <dbReference type="KEGG" id="chig:CH63R_10525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10525"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="90"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="590" mass="64907" checksum="F204F83C2E17FED9" modified="2016-11-02" version="1">MQLAGIMRSARPVRSSRGALHQITAPVVLSQRRAKSTMPFRLPDPRNEPNPTYEKNSPERAKLQEALKKLRAQLPAKSDLFYNGQTQAAAKSFNTVLPSEHATTFSNFPLASKEQVSSAIESALEAKKSWENTPFVDRAAIFLKAAELVVTKYRYEIIAATMLGQGKNMWQGEIDAAAELADFFRLNCNFAAEILEKQPTRGSDGMWRRIVADLDSSRLEWRPLEGFVYAISPFNFTAIGGNLISGPALMGNVVVWKPSPSNIYASQLLYNILLEAGLPPNVIQFVPGDAEEVTDVVLGHRDFAGLNFVGSSDVFRSLYARIGQGIGKRTYREFPRVVGETSGKNFHLVHPTADIEHAVNHTVRGAFEYQGQKCSATSRVYLPQSRAEEFLSSLASKVKQITIGSPDGKLDAFMGPVIHERSFNKIKGIIDESNKDPSLKLLVGGTYDGSDGYYVNPTVYLADSPDHRLFNEEIFGPVLAVSVYPDAEWSSTLKKVDQSGGGFALTGAVFANDRVAIREAEDALRYSAGNFYINCKTTAALIGQQSFGGARASGTNDKAGSADVMRRFVSPRLIKEEFFPQTEFLYPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3G4</accession>
    <name>A0A1B7Y3G4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155088.1">
        <property type="nucleotide sequence ID" value="XM_018305664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3G4"/>
    <dbReference type="GeneID" id="28869771"/>
    <dbReference type="KEGG" id="chig:CH63R_10690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10690"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23376" checksum="8B6924DE39A1B8AF" modified="2016-11-02" version="1">METSPGVVTKQGIWPGPITVVGTGLLDRVTFFDHSNRSYANYGTYHNTFIDAPIITSGGLLTHYQPPPRQLASNSGQLWSANDAYYASASFKTTIGSVRTGFTEEQRNKVRAHVQVARQSGLRSRYWDIPDWPIGYRDYIWKVLIEEKVDMLNVDDLESAARRGWTQGYLRDVLWMSLVSTYLLGRTVFVLFLFRRLLKRQCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y444</accession>
    <name>A0A1B7Y444_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A.Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_10930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155328.1">
        <property type="nucleotide sequence ID" value="XM_018305904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y444"/>
    <dbReference type="GeneID" id="28870011"/>
    <dbReference type="KEGG" id="chig:CH63R_10930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10930"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="455"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="524"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR06810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="562" mass="61221" checksum="FE877C627DC4470B" modified="2016-11-02" version="1">MDVQSSNPGFYGAEDPIEWGTSRKDGTERRDVRASAISRDVHRHIVSPSLVRDAFLVCVLRRHQGQHQQRPCQDDNTSPSWPEAGCDMIQPAIAAGLAEACCWHPSSRASLRGKAKAALLELSKCFPSLLLFAVILMRHQSDPAVASGHVLHIQRQPFLPRPGPSTTLTHSLSPLPHGSWSQVGFAGRVYFGWRNIPASSIRRMGAPNRAHQQTLRETHTLTERERGEKREREGLTGRSTKHSAETAAASDSGVRGPRTGARGPRRAANDSNSSSSRHQASPLRSHLPHTAPTRDFLACTESSLAPHSPPPLFFDSCGLPVTDEQQQSPSVLELNFCHLHPPPPKLPSTTPPTSTPTRNRHLQIEGCIFSAHLLAVDNSHFRSGRTLEFYPTHPPSSSTLFFRVSASISTMAGGKGKSGGKTSGGKATAEVPKKQQSHSARAGLQPSQLANHGPFQFPCGRVKRFLKANTQNKMRVGAKAAIYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y500</accession>
    <name>A0A1B7Y500_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155629.1">
        <property type="nucleotide sequence ID" value="XM_018303606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y500"/>
    <dbReference type="GeneID" id="28867713"/>
    <dbReference type="KEGG" id="chig:CH63R_08632"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08632"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7511" checksum="7A249C97B4A516E2" modified="2016-11-02" version="1">MPRQAQDLSLQSHQPPHMLIPPQGPSPTGATCPPSTHPIRLASPDTPLRFDHAGRDLPLAKFLRKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5G5</accession>
    <name>A0A1B7Y5G5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155809.1">
        <property type="nucleotide sequence ID" value="XM_018303786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5G5"/>
    <dbReference type="GeneID" id="28867893"/>
    <dbReference type="KEGG" id="chig:CH63R_08812"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08812"/>
    <dbReference type="OrthoDB" id="4833427at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="778" mass="85789" checksum="4D8D39B130E1018F" modified="2016-11-02" version="1">MPARPKTRSSKSGTTTPTSRGKPAGKAGASAKKVPRSRTFTGCRTCRGRHLKCDEVRPVCSSCRRLNLVCEGYDARLLWVPDPLCSTEQRQSHRGTSYRYPLFTEKERSSMSVDIVDSMGDRAAADIIFDIDERDVVAGDAPHLAGPFGVFRAFEDSTAPGSPPSDPSPSGSSPNTSPIRTLPDEEVGDTGEDVEDVEEVTLEPWSVDDNSLAMGPYFPPGSFYDFNTDSILNSTNQPWTHGEGTGDLTQMMAVDGSALDFLFTPTSPRTPDMAHAGHEPAAEGSTPEEQDSAHGFTSTLTFEQGLPAQRKSPTPFTNHMPGVEPCLPAHAASLLRYYKSMEESSSSVKGVRISPWQLWLLPCALETFAELSLWNTTSHTRHSILCTLLAKSAFHLHQSLSKEGKKEASPWFDIGRSYQKSAQSHLKLALQGESGEPGQAKYNEMLIAILATAMVSVMYNGSRAVKIFLLDAERLIRLRGLAMPKSFHVRVLHHVYTHLRVIAESTDIAIDTPKTQAEAATEMAVSLRKFRIAEDSLGADLDLSREKPAEVGYSDIHLDISGHWPATMYPDIYGVPESLMTLLSQTISFANEKVKLEAIAMYDSRVSLALPRHIKKLEQNIWSWSLESRDVESGPSRPRGLVTKDTRLVDHPAVRSLTLAMHQALIIYFYRRVHNLSAMVVQDSVRKTLDFIQPCLGETADDHDFATSIGWAGFVAACEAMGPDLQERGRKVLEAIDNKGVIFGTDKPSTLAQSVWDRRRETGDWTLSWPDLMPTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5M3</accession>
    <name>A0A1B7Y5M3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155816.1">
        <property type="nucleotide sequence ID" value="XM_018303793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5M3"/>
    <dbReference type="GeneID" id="28867900"/>
    <dbReference type="KEGG" id="chig:CH63R_08819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08819"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="30721" checksum="7BE25C6DABCEF71F" modified="2016-11-02" version="1">MLLRRLQPAAAARPLRSGAFPISAPCPANRHLPRAHSPAAAAAPFTTSRALRDDDASANHYDTLKVAHDASPSDIKKSFYALSKTHHPDHNRNDPHASRKFHAIAEAYSVLGTPAKRAAYDRSLPSSSSAHGHRRGSYHSTGPAGGRPASGLSRRRTTFRGPPPSFYRSGGWGAQSAKRREAHEGGGGGGDGTGTAQAQPGMGPGQDPYGHTRSPKVPHFDSETHTQTQSRQDSRRAYRIMGTEVPNGPQETSVGAFLVVSGILFFSFFIPYLAVGGWSRKKKDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y643</accession>
    <name>A0A1B7Y643_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155991.1">
        <property type="nucleotide sequence ID" value="XM_018303968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y643"/>
    <dbReference type="GeneID" id="28868075"/>
    <dbReference type="KEGG" id="chig:CH63R_08994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08994"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="86" mass="9499" checksum="716E201BB7BCD188" modified="2016-11-02" version="1">MFGRLRRTGSRFWIPERRPRLVQRDYGHTSGIMRLLTSLTFGVFTLLALPVSLVAAQKVNSITDAVAQLPTCAVSSALLLKLTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7B8</accession>
    <name>A0A1B7Y7B8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156392.1">
        <property type="nucleotide sequence ID" value="XM_018304369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7B8"/>
    <dbReference type="GeneID" id="28868476"/>
    <dbReference type="KEGG" id="chig:CH63R_09395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09395"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="270"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="610" mass="68457" checksum="B05063F55812F21E" modified="2016-11-02" version="1">MDLNGVKRRDTTKGPPLRILSLDGGGVRGYSMFIILQELMHRTFVEIEGRAPRRNEIPRPCDHFDLIVGTGTGGLIALMLGRLRLDLEQCKELYVRMTRMVFETDKTIAGIPYRSTLFKASKLEEAIKEAVREHTVYQKEGNDGTENDMMSPLSGYNNSNPRRHASNASTVSFSARSPQAQMTRPAFNSRYGDPNARLYDARETRTKTAVLAMYKGSRKGTPAAILRSYDSRREPPPEFDCKIWQAGRATCAIGLAFKPIQIGQSVFHDDGGGTFNPAPEALDEAVVNEWPGREVGVFLSVGTGRRPRGSDANSHMWYEGFLGEFAEARRKLISKIEGCEVIHEQMKKEHLLKRNVNVENYYRLNVEVGVGEFGMNEWHRLAEISTSTRQYLRREVEQRMIQGASAKMAKIHKANIRFSRMPDVPELVKSNSETVEPLSFAVELPGDTPTSWPPHNTPPSRQSYESGTEHLHIPSPMSPSPRSSGERLQPSPASRLEQRLPPLPKDDEIDRLVVTAPTPSQYRYAAGTDKIAIMSPDEHPRWQNQQYSNGPTQQSQQPQRIPPPLPPKTPLPEHQAAGGRRPIGSSPLPYPVDDEPPPVNMARKPEYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7E6</accession>
    <name>A0A1B7Y7E6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_09451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156448.1">
        <property type="nucleotide sequence ID" value="XM_018304425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7E6"/>
    <dbReference type="GeneID" id="28868532"/>
    <dbReference type="KEGG" id="chig:CH63R_09451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09451"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR07930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="317" mass="34736" checksum="014F4E9694A48E00" modified="2016-11-02" version="1">MQFVRFRETVSQPVIAAFCAGGVAGAVSRTVVSPLERLKILFQVQSVGRDAYKLSVGQGLAKMWREEGWRGFMRGNGTNCVRIVPYSAVQFGSYNFYKRSIFENTPGADLSPLARLTCGGIAGITSVFFTYPLDIVRTRLSIQSASFAELGPKSEQLPGMWATMTKMYQTEGGVSALYRGIVPTVAGVAPYVGLNFMVYEWVRKYLTPEGDKNPSAVRKLLAGAISGAVAQTCTYPFDVLRRRFQINTMTGMGYQYKSISDAVKVIVAQEGIKGMYKGIVPNLLKVAPSMASSWLSFELSRDFLVSLKPEADSEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y864</accession>
    <name>A0A1B7Y864_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156646.1">
        <property type="nucleotide sequence ID" value="XM_018304623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y864"/>
    <dbReference type="GeneID" id="28868730"/>
    <dbReference type="KEGG" id="chig:CH63R_09649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09649"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="192" mass="21586" checksum="AE30F9191EAC108B" modified="2016-11-02" version="1">MSVNPVVKSAMLKSLASIAAQVAARWHDPIPPPLDWQRVVEFAVFGLVQAQINTHWQRLLEDLFPTRRPQLNELDERSFSDRPLPPSPRVSGISWPNVIGKLLLDQTVGLFIMNAVFLVCTNAVRLQSAALVYEAVSSRISDVIRAAWKLWPWVSLLNFLYVPVEKRVLVASCVGFGWNMYLAFTVMAKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8N3</accession>
    <name>A0A1B7Y8N3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156858.1">
        <property type="nucleotide sequence ID" value="XM_018302080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8N3"/>
    <dbReference type="GeneID" id="28866187"/>
    <dbReference type="KEGG" id="chig:CH63R_07105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07105"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="492" mass="55133" checksum="9932C6CB58BBDA22" modified="2016-11-02" version="1">MSAQLTQISFGAQPRDYAPAGQRFNPGDYHQQEADLREALLRLCPENLWHDGSYSAGCPRPILVGEYHQRQMEDLHEALTTAIIDIVQRWWTDDDARFWERMPLEAEEEDLLKWIEKQVSAGNMPAFSKCLGSWRPDFLVEKDEHQEENYRITEINARFSFNGFMHEAYGQEVLNKSVEGEASVLVGATDPNQILEGLFSLFQPNRPLHLLKGAEHGIDIHMFIDAVWRRFGIKPRLITPADLRMLPDRGEKGGRRLCCVTKDPSSPPSPWSFTADNGEIWEEIYQIGLELHQRELAALETETLREISLRCFNDMRTILLVHDKRMLGIVKQELPRLVASGALTPAQASALDRGVVDTILPGSCELDHLISASVASPRLRHSYILKPIRSGKGDGIIFGDDLGPGDWVSALRKLVSPKVVPGITCVVQRRITPREYDLVLKGSVGKVRYPLVGTYHVANGKLLGLGTWRASGGRIVAVSSGGSWICSVMRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8V3</accession>
    <name>A0A1B7Y8V3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157019.1">
        <property type="nucleotide sequence ID" value="XM_018302241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8V3"/>
    <dbReference type="GeneID" id="28866348"/>
    <dbReference type="KEGG" id="chig:CH63R_07266"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07266"/>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="402" mass="44136" checksum="47F6B7D6CFACF05D" modified="2016-11-02" version="1">MARQNEQANGNRFPTPPSSRHFATAEASNIKAFAAVCSQEATAEEYPLAATIQRNVPVYDLPAYSSLTEAQRSALQDEWYRVLISGPGVFVTKGLYRDRRLIEAANAAFASVIEQERESGAAKGDHFASAGKNDRIWNSFSKHGLADPASFVEYYSNPYLGLISGAWLGQGYRITAQVNNTKPDASPQVCHRDYHVGFQTAEAAAQIPRAMQVASQLLTLQGAVAHSDVPLESGPTRVLPFSQTFEPGYVAYRRPEFNAFFLENYVSLPLEVGDGLFFNPALFHAAGENKTADVYRMANLLQISSPFGKPMESVDAVPLIEKCWDHLVTLYEARGLDDEVKAFVAAVAEGYPFPTNLDSNPPRNEGMAPESEQDNITKSLTENRTKEEAVEALKKFVARSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y983</accession>
    <name>A0A1B7Y983_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157171.1">
        <property type="nucleotide sequence ID" value="XM_018302393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y983"/>
    <dbReference type="GeneID" id="28866500"/>
    <dbReference type="KEGG" id="chig:CH63R_07418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07418"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="116" mass="12901" checksum="70A3846B2DD12D44" modified="2016-11-02" version="1">MCFHVSSRDPVFIQEEMLSRSGYLEYDFTGARTSASSGRQRKDNGRPAQTSGPATGYGIRLGKSAGAFNEDDVTKTIWLRHREDATHADGNEWAAGDSHCWQGFARSNSDFFWMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9E2</accession>
    <name>A0A1B7Y9E2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157063.1">
        <property type="nucleotide sequence ID" value="XM_018302285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9E2"/>
    <dbReference type="GeneID" id="28866392"/>
    <dbReference type="KEGG" id="chig:CH63R_07310"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07310"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125789" checksum="F0E411DDA96C012E" modified="2016-11-02" version="1">MRRHESTRSRSTLTRSKSTTSVRSAIQRLEHIDPVTAERDAHIAATLSFARSGLDPGTGMGASVSRHHARSATMNARPAAIVSHDRPQSERGSQGYHENGLRRQNSVRFAIREPRSKRPQTQLSNDDSSETGTVRRRSVLKNVGNCPLGQASDKVERPFVSTYTTSYIDSLPPVESFGSPDECGPPPASYRRLRKSRSMFAPSNPNSKTSHSFKECSEQPSPQPSLRRKSMQNMKGNSHLSKTLGLRAPKSTSFLKVRGAGNGSSIGTREQNDLVVQEAEDNFRRDVENQQHLRPRSSIFFSKTKKSRSPLGLRKSMRDNSYDTHFDGSANVLTVSKDASLRRKARKVSSSLKTKLKEIFRRSKKEDSITPANEAEPAVVAEDQGGVETEQDDPYMDIVDPVLTDECSISQVPSRVPSLHNASSAQRLRSRQGSIESIGSEMKVSDEKSRVTSWTSSGTHTLNSQSTWGGERDRQRLSIIKENGPHQSSSSFRRPSRGDRNPYEFGSLSPPPPSVPVHSGPSVDSARVYSALMTRLNEAKQRQQERESRKRNSGDWSSERLGSVRLSKSDDEEGIEEDGRQKPPTIRCVLHEDDVFRDSPWEQQPSQEADDTEIVNLAENNAASASGSVVHHRQEFESETTLTSYKSYPRFGTSNGKELSSSWSQKAHSEDTTIAPKTLSTRRSAFFGSPTCHLFRTTSPYRKALQASIKESASGPAEARSPTASSLNLDIIPLKRRPSFSKEDPRLAYSESIYSDELLTPPSIPQLVSTPSGLVVPHRDPSHQATHVDLRNTSSATALSDAVVEHGPDRAPLMFARDDDTASTRWAPSGPGEFTSMMQADRTVSNASSVEWKTWLSANASKTDANLANARAHNMREAQHPKTDALRTLGHVREGAEVEESQSPVSYKPTDGEKSRLQTPLRAMSHNSRQTSSTSRIELGVKTHILRRSRDENAAPLSDVRISKHIRGIYGPPPIPPRSSLRSTPSMALMQPRSSQSNIPIKSVDSKNSKMRSLGTILKLQSADVSSSPNSRSPIKAARYNGLHNGLQSSTSSPGLTMAVEKQFGPMLAGEEPSRGSPRERRSSMRRRLLNSSDSEIADRSDSVSLDDWRPHSGGGKQILEDFLSSRRQVSVASNDSVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9V4</accession>
    <name>A0A1B7Y9V4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157350.1">
        <property type="nucleotide sequence ID" value="XM_018302572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9V4"/>
    <dbReference type="GeneID" id="28866679"/>
    <dbReference type="KEGG" id="chig:CH63R_07597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07597"/>
    <dbReference type="OrthoDB" id="4844464at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="595" mass="67018" checksum="D00A3E4427C7C857" modified="2016-11-02" version="1">MAARYPPGFRKYLGDLPDAMDFLDQVTQSDLDPEIIERAKALHRRAHVCATSGDIYGARGLHREVEDIHVEIHKVASYRAFIGRLEDADTANLLACYLPERAWAREWARASGSANACEFCHWAATRDQAMDCELLAIPLVAVLDRYVDERRRYCHWLRRLVAVVDESHNLPPRRAPIDNYMVRVAEYSRARGPADNVWTYNRIVATMRETRARIDGTQANGRQLLRNGWQGAIGKMDRDSATAPARARAFLTPAQTSELTQAIHYDARLYYVARFEIVEGGRCVDQRPRRWVLDHLRTHPPNVHRDRFFGGPLLTLETIWPLYEVDERAGVWVWCLWDETGPERWHRLFVGLLDGRDVDLHDMVVLNQRDEWARDIAIRWLDQERAREDRENEAGGDSSDDQGSGRGSVVGADASLYNADDEAESSEDAAEDEYDKDDDDDDDDDDDDDLSPKLAYAEMHSHVLDQDRMSRPGEFSNLDWEGDAWVDEYSVHGSDGDEWDDSDLYDPSGGEEWDEYSGGSESDLDGGEWVESDSGSGSDSDSDSDSDPDSDDDDKGEMASGSDIGPPMNPGTTLAEVMAACRGCDAREGGTGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9Z3</accession>
    <name>A0A1B7Y9Z3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07562</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157315.1">
        <property type="nucleotide sequence ID" value="XM_018302537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9Z3"/>
    <dbReference type="GeneID" id="28866644"/>
    <dbReference type="KEGG" id="chig:CH63R_07562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07562"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="190" mass="21341" checksum="59EA3E156A33D63D" modified="2016-11-02" version="1">MNGIDILCDAAGSDMLNSLYSPPEVPKEPAQHPPQQLGKRKLSTSDTSPSSIHVCHICKRVYERADHLTRHLRSHENARPYQCSRCPKRFNRADLLTRHETTHDRDNAGKGRTFIRRSDRAAEACLNCAASKSKCEVNIGPTTLYPGHETDAHIGRQALFSLSLQEPAMRSCFQAHTSASVINRWYFNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAX9</accession>
    <name>A0A1B7YAX9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_07813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157565.1">
        <property type="nucleotide sequence ID" value="XM_018302787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAX9"/>
    <dbReference type="GeneID" id="28866894"/>
    <dbReference type="KEGG" id="chig:CH63R_07813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07813"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="292"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="628"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="674"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="964"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114803" checksum="9A5F8D6AB0150318" modified="2016-11-02" version="1">MEPALQQRNPTVENNTELTHAQTDSRPAAAAAADDDHRETPKMLAHDSMVTVRLSEPPALTLDTNVGPDSPPRRRPSTVRIERLPFPVEEADEAEAKNLREDDINDTPPSDPATPLPVTAAAKSLQDELVGCEEKKDEADEDLATSVQAPRDQGGHESQHVHDEDNEEDEDEEVNWDELQKSEAQEPRDADTDRSTAMLLAMLEQENDKLATNPKSIKVQAVEQVAASSRPRPPSMAQLRHMVHGPTPPALRYSMLPPPPMTDLEFYAALVKDYQQTAARLPTLLSNKIRKGIPPPLRGVVWQSMSGARDSTLEEQYERFTGESSPYEPIIGKDLGRSFPGVDMFRDPEGDGQRMLGRVLKCFSLYDTKIGYCQGLAFLVGPLLMHMPDKQAFCVLVRLMERYDLRSCFLPDLSGLHVRIHQFRELLQEHMTPVSNHLEDLQVDPAYVSQWFLSFFAVTCPLPMLFRIYDVIFAEGAPETLMRVALSLMQKNQARILACTELEDVMQLLLSRGLWDCYHYNADEFVQDFVSLSGVVTREKLLQLEQGYRDAQIASANAARSSDVTTAASRFLGRIWASSTIISPKSSSTLSPGLTAPSRPMSMLRRSTSKQSLASTLNSMEASSVSVLSSASTEATTVSRDSSNTTDDYSSIRESTPIPGGKALHGNSGKNNKENALHTQIEDLLTALTELQRNHAQLASELQKEREQREEDKKAVRSLLDGLRKKASNDSVSTDASVDTLKAADDPATEAREGGQGDVSTAKAGGQDGPSPEDLSQLLDSVEERFGRHGSSDRRVSLGRESRSEMQQELQQLKDQLASAVSQSQDYNRKIHDLDQEISTLKDQVRESHSHARILHQDKQRLEKQIHTMRARASAAEADSNTQPDSDGPMRKSSASGASGLRELKLGRSKSTPSQAGLILNKRSSSLPKPHDSTPPSATQAPLPPAPPPPPPIDDQHEALLLELVQAKTAEAIARQEAEETKQKLESLRKAYGAAAAETSPAAGSAASAAMGVFGRLTGAATEPAKPASPATTPAVAGAAAAGGFWGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB35</accession>
    <name>A0A1B7YB35_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157734.1">
        <property type="nucleotide sequence ID" value="XM_018302956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB35"/>
    <dbReference type="GeneID" id="28867063"/>
    <dbReference type="KEGG" id="chig:CH63R_07982"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07982"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="213" mass="22623" checksum="4A871984D0AA2C9D" modified="2016-11-02" version="1">MAATKKVAVIATSTRTPRIGTKVAELVRDVIAPDAAAADVELAFVEVASFNLPVFDEKLLPAQVPAFGEFAHEHSRAWSREIARHDAYVLVVPEYNYGLAGGTKNAIDYLYNEWIGKPVAIVSYGIAGGNSASSQAQKTLEGMKLRVAPTRPALPFAGGGTGPDLMAAIGGEIGDESRENWKAEAETIRKAFAELKELLDAPPPPPPPAKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBD8</accession>
    <name>A0A1B7YBD8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157930.1">
        <property type="nucleotide sequence ID" value="XM_018303152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBD8"/>
    <dbReference type="GeneID" id="28867259"/>
    <dbReference type="KEGG" id="chig:CH63R_08178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08178"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="763" mass="84391" checksum="90FFF67AE191BE54" modified="2016-11-02" version="1">MPDHAGTAAAAPPQSESNPTPPKELYPMVNWKYDLFLWVLGVLVDLFFREVHPRGSWKVPKSGPVLFVAAPHANQFVDALILQRTLRHEAGRRVSLLIAQKSVHGFIGWGSRQVGSVPVGRAQDAAKPGTGLIYLPDPINDPTLIRGVGTKFGQGEGEIHGMLFLPSAKKQTGASVDIAQILGPEEIRIKRPFKGKLPLEQLTGRDDIDDNGNFTNKDLKGCKPGFSGTKYKLAPHIDQTKVYEAVFDRLRSGGCVGIFPEGGSHDRTELLPLKAGVAIMALGALAESPDCGLKIVPVGMNYFHAHKFRSRAVVEFGPPFDVPPHLVEMYKNNQRREAIGQLLDSVYQALSAVTVSTPDYDTLMMLQAARRLYNPTGKKLPLPVVIELNRRLAMGYEKYKDDARVVGVIKSVKQYNKELRYVNLRDHQVQYAKMSIPKVVFLLLYRVTKLLVLLIGVLPGLILFAPVFAASKAISVRKAKQALAGSTVKIQGRDVMATWKLLVAIFLAPTLYHFYSAVVTYKVWQDHLWGHIPEWVPWWSTYLVMWPLMVGITFAALRFGEVGMDIFKSLRPLVLCLNPASSYNIQQLRAKRADLSSQVTDLINTLGPEMFPDFEKTRLVADPYKADGYSRPRTPPTRRDSDASSAYEAATPPSISRRTTHQSSRGLPRNESYSNIGGVGIFSTRPPSRSRSRSSSSGGGLGSGGFPISGFTTLDSAGGFDEASKKIREAMKLRRRKSGDHRMELGADDSEDEEYNEARKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBH8</accession>
    <name>A0A1B7YBH8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Het domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157953.1">
        <property type="nucleotide sequence ID" value="XM_018303175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBH8"/>
    <dbReference type="GeneID" id="28867282"/>
    <dbReference type="KEGG" id="chig:CH63R_08201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08201"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="142" mass="15863" checksum="BDC215A1184365AD" modified="2016-11-02" version="1">MEEHTAYCLLGLFGTSMPLLYGEGSKAFARPQEEIIKSSNLTTIFCWSWTKSVPAHWTSLFAPSPEAFQGYAGVRWETRQDAETLRDTVTYYITNAGLSIRLPVLVTMADYIVSLNGSRTYEDPAGNGISFTEAMNPRPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBY5</accession>
    <name>A0A1B7YBY5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157992.1">
        <property type="nucleotide sequence ID" value="XM_018303214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBY5"/>
    <dbReference type="GeneID" id="28867321"/>
    <dbReference type="KEGG" id="chig:CH63R_08240"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08240"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="249"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110654" checksum="4B5C0FA6C3A3CC99" modified="2016-11-02" version="1">MPYTDTPLGIMADQDPNALFGLDDSALAVAPSFLDDSDSQNLESASNGASNIASDGQSYYNATNWSFQDTPPYDSYSTIAATSAAAATPLFQTASPWEQLSPNQHHQQQQQQQQQQQQQHQHHHAPTNVTSPLDHSTLAQAGFYAAPTPAPSHNQHSHRAGQHHTLPQETLSLLTPAQQEKLRNIAMPAHLQYQSPKSEPSPGSATSDHKAAGLSSPDAHDLSSKDSRKRKSSADADDDDDEDDENHPVKKTAHNMIEKRYRTNLNDKIAALRDSVPSLRIMSKSARGEDTTEDREELHGLTPAHKLNKATVLSKATEYIRHLEKRNNRLCDENTAMQARISAFEKLFVAGAMNGAMSPLQQPPTPMQYPQDHYISTPIGTPRGEPAQGMIPVPDDMKRIISAQMAVGQPYPVPQQGYRGNPALMRQQQIQQQQQQQQQMQQQGRWGAGPYFGKLMVGSLAGLMIIEAVRENEQSNESPEGRGLFAMPIQLLSYLGSTSHMHIGGYYISPAQIISHLKFLLFLGTMLWVFVPSLFVSSEKKPKKAQHLRESLQAAGSVASPIHVRRQAWLTAIQTVWVPQHNFFLEAAALMMKTMKLSMRNAIGVHGYQVLTGLTEEQEAARVKAWSIALDAQLAGGDVEINKSRLTLTLLASGTLPDTPSRLMLKALHVRVLLWDLGSKGLHNIVAKKLARSLWNEARNLNRVRSQLRRNSEQVDDDLPEHLAALIELECDDILNNAVIQRAYNLAWNLATTEGVTEHNDGMDSVVDDQAVRSPLDAVAAWWSSQTIQRALVTSLEAGKDDGDAPRVVSTCLESALKTAPIGSGTQARALVARAVLVDEKRGANIAAAIQNMQPASEQGSIGRIAAIFDSSTSAQSPEVQMALKCAMAIAHLERAKVTAAAPHEGLQQVEKIARPRTTANMSLLGCTALFKLMEELFANRSSTECFSTPLERLAGSLRIWIGSAPGEKCGLEQDVRHKMVDRCLGITKSVVGMETDTGYGSMSECDEEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDH7</accession>
    <name>A0A1B7YDH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158606.1">
        <property type="nucleotide sequence ID" value="XM_018300756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDH7"/>
    <dbReference type="GeneID" id="28864863"/>
    <dbReference type="KEGG" id="chig:CH63R_05781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05781"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="589" mass="66068" checksum="A48B46108B2E9FD1" modified="2016-11-02" version="1">MPPRRQQDLPVESSWRLVEGGENDSFDTSILPDLEEDEGFISTDPSQIPSQSFSIGGSQESHHSVQDFMNKADDERVILRSPFQPTIRRDPNRSPDPEFVMPSMRFGATPGSSTSPRQSSGRSTRTIRPGDDPYQQQEVRRRVIRQASTGSPLKLRRGDHGRGRDYYDDAAEEHRTVTERLSESLPGAIFNVLAWVFNVIGMALGYVQKPLALCLAVWLFFGASIMLQNMVTKSLTASLSPFCRIPGAAYLDLPFCPSFTSTTGGGQDSGPANVEFDDLMNVQSQFEQVLERSADGVSLPMEMKRSESSIRDLRTMVRYSELPQRDELVYEFNEYIDTARLTAADLQKFNVHVGSAVDSVISINRWTSRYLDTLSASETTDVGILSQWSSWIFYPFTPTVTPFSERTLLDKYVEHTAMVSDRISSLIVEAQGVLLLLTKAEEHLNQIYELVTRSSNSVKSRRDEVLWTLWTLVGANNKRLHNLNAQLSLLRQVDRQRSTAVAQLSALIVDLEKIQAGLGDLRDRVAAPELLRDSVAAIPLSVHIETIDRGVERLEDARQRIRANENDKIREALARGGTKEDDKLIDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDP8</accession>
    <name>A0A1B7YDP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_05722</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158547.1">
        <property type="nucleotide sequence ID" value="XM_018300697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDP8"/>
    <dbReference type="GeneID" id="28864804"/>
    <dbReference type="KEGG" id="chig:CH63R_05722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05722"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23952">
        <property type="entry name" value="Utp17_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="544"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="960" mass="105268" checksum="AE8A527BD398A43C" modified="2016-11-02" version="1">MAGPSTPRSREDAKKRKREQNERDGQAKRLRQRGKQSPGKHLKNGQADAGDLRDNALNVLSQLQKTLTDDQIESQLVKLGNTEAQEAGWQVSLPMGGRMADIDPIFAENEKYLIITYNTSLQIYSVAESLLIRRIVLPVVQNTYAEKSSAPTIVATRQSQVKPDFLWVACSDGRVWRVNWKKGTAVYNEFRTQSQTALDMSVVAIDGSNNKTEVIYVSEAKKQSRGEIVAYFGPDFTQPTSEVLFTTKQVDQGIHLLRSSADGKIIVGATREGLVVGTVAPEITQTDVGLECEFFTFDTADIVCSLDIRVTNNKDGSVLDLISGGARGAIYFYNDILRKLQNINAPKSKKDGLQGRKYHWHRRAVHSLKWSKDGHYMISGGSENVLVLWQMDTGKMDHLPHLSGSIENIVVSPTGASYALHLDDNSAMVLSTSEMKPSTYISGIQSAARFTSTPKDLLVKRVWSMSDEVRHPVPAALNPAEPSRLYVCTGTGQQAMLAGELQSAPLLQSFDMESFRSISKQALARTQPTDFNITSKGSPISEPRITHVAFSHDGQWLVTVDDWQPPKRDLEKVAPEAREQFVRERREIYLKFWSASAGEESFALSSRINNPHVTSRPETVLALAADHTANRFATLGDDGMARIWQSRTRQQDGLTSKDAAGEALHSWSCSLAVGLGSNVGADALAIAGETTSERSGSLSFSEDGSTLFVAFGNSNDGTVYVIDTKTGDIRLTLENLWKGHIRRLQVLSPYIITLSDDLRVYDVVADELQYGIQLPSGRNAAAVKEFSHLAIDRKSRTFAVVVPGGQASQLAVFRPEEPELLCVRRIPHRITSLVSTGSSSGFVAVDDAAQLWTIAEATDPASVVLSRPLEDMQLDGEPVATGAILDDAIEDEDMASDNEQEEDVATGEEMDLDDDDAQPAVINRQKLAELFDAAPAFAMPSVEDMFYKVAGLLSTKPLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEB7</accession>
    <name>A0A1B7YEB7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158892.1">
        <property type="nucleotide sequence ID" value="XM_018301042.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865149"/>
    <dbReference type="KEGG" id="chig:CH63R_06067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06067"/>
    <dbReference type="OrthoDB" id="5422628at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1498"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1509" mass="171535" checksum="7D48B84E61616ECA" modified="2016-11-02" version="1">MAQERMSELDSIVRRQYHRFPAETWELTRKALEDPEPYRLFQHIEVLIFTRRIDDVLRKNPEFRALLADMYGNRYDWLRDADLGTGRWENSRENAAESLAARAKESEKERADTDKKKRDLMIEKIAEGGDDVVRWAKVLGFENVAFPIYEIQAAATRMKTERADLGAEGGVAGYGVGEAREDIGGVDATACPDGPEGTYGPSSHMSMGKQLAAMSKEHKQPPPVPKAPAEGGAAPRNPFTTEWRHRDAPNGWTYPATFDPYYSSNQFIRRSTSYKLPYVGRIEDDDDEEESDNAVLETEETEDDEALEAEAERDSQARPATAPTGLAAMITTTRLKPVGVSSRTESRSQALKRKTRRPKEQIRVRRNMTTVSTLRQHSPPVLPFFKTKRRTDSQQGPTTGESAAGPSITITSPTDQTRPFEQFEQETETSALAPALEGSRIYTPPREETLLSPQSTDETTDEDDVDMVDADSEYDVEDVEGEDEDDAVEMMLEEGHGQDWLIEWLKRDRSTSEEDLRMIHYHGWRVHSPKVQLILIKNFLADEDMDRTMDWERKFAEIGEFLQYCLRREGVTSRDWYVDLCECIGMLHMHWMFEQYHYGDKKLVVDFPAYSGVSTRLPPLLDGRDLIVAKRPKDPVRPRYLLHRVPESVQDVDYQIPGPLLRTMFMTWFRQDGNLVWSADPNGPMPGSGQRGEVFQYQPDFNMALTEDLWFVHCMDAGPETTATGLRGEANFYILNSEYVPGEVRESEVGERTHKAQIYYPEGEAQQRFARYRGAKRAALQQCLSHFDAVENVAIQSPFRKLVLPLTRRQKQRAREVAGINIVYKPHAVKTLPKGAQADDPLGLVYWFQKMRDNHGERADTVRGETEEAHRGAVGDLDTVLLPHSFLGPVTPFNFLKESERRLVARHTLLVNLRDRVRRAYGRNPRQMLEGVVENMDRGRCGEASWNMRDELTAHRERHGRYLEMNDMELYWVDFVCGPSTNAKAQREALPNLGRPFEVFTARVQTLLDEPSRECLFGLKENKVGLQQVTMALNTSLRQGDYVFTEDMVNKYSWVLADHGRLGYERAETGEVQISRPECPWHPENRMNWPRDDDHWDPATDPWTAANVPSPDHTWDWETAFANIEKVNATRRATKRMLWSIAYRVGIELDALAAKLAGVDDTLSRTAKWEARAAQLEDLAASWRQRFDRPAVGDGDGNGNENENGDGKVARRPASYISVVKAGYPGRWKKKMTEEQAVEIVRRGIIDELSAGATTLWPSRPRFSRVGGRDVMTLHRERVWEWARPAVVGPKKRFFSVNRWPVHLQSEATQTEIRTSAIRAKAEREAEEAQIATEMARVEARARPTAEEVHKAQLARSLSVPFHEANDPRTQFFPGHTEYWEGDTPLQKKVLEAHVQRVIDEELGPNDGKAPRGTGWFGRGRAQASSSGGGGGSGDAFAFPDVVPDVVPRSVPARAGLSLGRQTAVSDGMPSIVPRVIERREPLLSPRYPPDQQPQSREPQRRVRFEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF10</accession>
    <name>A0A1B7YF10_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_06100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158925.1">
        <property type="nucleotide sequence ID" value="XM_018301075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF10"/>
    <dbReference type="GeneID" id="28865182"/>
    <dbReference type="KEGG" id="chig:CH63R_06100"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06100"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="61959" checksum="25F53B427FA37F78" modified="2016-11-02" version="1">MLMNSNTQNGGIQETQETMAGPDSLKKVPSTDENARGEHVEDFVDDVEISLTPAEDVSYGRTGFRGLADSPYVGGAALLASLGGFSFGYDQGVISIINVMDQFHAVFPQAATPFGKGFMTGMLEFGAFLGCLFMPTLADRISRKRALAVVVVIFNVGAIMQTAARSYGVLVAGRTIGGIGVGTLAMGSPIYISEIAPPNLRGTLLVLESVSIVLGVVISFFITYGTRHMASEASFRLPLGLQMVCSTLLGIGIFFYPYSPRWLALVNRPQEALQSLVRLRRLPADDHRVQAEHRGIVTEVEVMKIMQEKHHPGKKGLMLEVAGWLDLFSPKLWRRTAVAVGIAFFQQFSGINAFIYYAPTLFESLGQTSEMALVMSGVFNVLQLVAVCACFFIIDKLGRRPLAILGGIGGGTAWGIMAILTGVYSKDWAANPAAGWAAVAMAFIFVLLYGISYSPLGWALPAEVYPNSHRSKGVAAGTATVWLCNFIVGVATPPMLDKLGFGTYVFFGAWCFVASVWAYFLVPETKGKTLEQMDEVFKDTTAQEEKEIIKQQILARRGLQPQGGAGGEGAKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFJ4</accession>
    <name>A0A1B7YFJ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_06545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159370.1">
        <property type="nucleotide sequence ID" value="XM_018301520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFJ4"/>
    <dbReference type="GeneID" id="28865627"/>
    <dbReference type="KEGG" id="chig:CH63R_06545"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06545"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="59587" checksum="44FFDBFF4EEEFFE7" modified="2016-11-02" version="1">MGIVEKQTPSPPPDEAQVVVAVDSVPRDATDDEVENLPHLVDKLPPAAWAAALIGASERFSYYCFVSIWQNYMQNERGSHAVPGALGLGQATATAISNGFFIFLFLMPSGFAVVSDVYLGRYNTLLLGLALSLCGSLVMFATALPSSLDSGAGLPGLIVAMVLVGLGVGATKATVSPFIGENLHQKSLEWQRLLVRQRNGTLAVVDGTRTLQFLYNAFYWFTNIASLSSVPATFLEMEFDFWAAYLMAAISLVLAASLLLLFKSRLVKIRPGGNSLPQAIRVMTMAARNGFNLDHAKQSYQMEACGAQVPWGDKFVDELRRSLLACRVIFCFAFFYLAITQMFNNLISQAGQMQLHGVPNDMLQAMAGVACVVFGPVIQALYNFLAKHRISFGPMARIALAFLICGAGMAYAAGLQKIIYSAAPCYDAPRACPASDGGRLPNEVNVWAQLPVYVALAVAEIFGLVTASEYAYSKAHKDMKSIVQAMVQLSACMGSLMAMALSPVSRDPHLVIVYAAIAGVMGLCSALFWWKFRKYDRLDRELNNLDRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFZ6</accession>
    <name>A0A1B7YFZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159387.1">
        <property type="nucleotide sequence ID" value="XM_018301537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFZ6"/>
    <dbReference type="GeneID" id="28865644"/>
    <dbReference type="KEGG" id="chig:CH63R_06562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06562"/>
    <dbReference type="OrthoDB" id="4842973at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="193" mass="22013" checksum="AD5B7739AAF06266" modified="2016-11-02" version="1">MNAPVVLRGKENYKKWDTSIRQHLSDKGLLVIIICDELDPATGGPALVQSLKVCSEAYNFILNSIDDTILLALSAHGLIHERGYPWRLFQAASSLFRRDHRFIASTITKLTQAKFSDFTSMEVFLSYFHLGRICLEEDSTSQTVSLLLLNAIEDRHGEVYRTHKYRQTLIWDDLVADLRAVDRQEKQDSKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHZ6</accession>
    <name>A0A1B7YHZ6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160142.1">
        <property type="nucleotide sequence ID" value="XM_018298896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHZ6"/>
    <dbReference type="GeneID" id="28863003"/>
    <dbReference type="KEGG" id="chig:CH63R_03921"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03921"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="333" mass="37460" checksum="B984FD251616C3FC" modified="2016-11-02" version="1">MASQLKIAAIQAEPVWQDLEGGVTKSITLIEEAAKQGANVVGFPEVFIPGYPWSIWAKSPTDNAAFMDEYFRNSLVKDSDEMKRICAAVKEAGIFVVLGYSERFKNTLYIAQSFIDENGVIVHHRRKIKPTHVERAYWGDGQGESLQTVAPSTLHPSVKIGGLNCWEHTQTLLRYYEYEQNVDLHVSSWPVIWPHPTNKDGERDPDWPGHISDEMSLRFSQIVALEGACFVMVCTQVVSEESKKRCRIDEFGYANSTPGDGGGFSMIYSPWGEELVKRPPPGEECILYADVDLAEKTKAKQNLDIVGHYCRPDQLSLRVNKYPARPVFYAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIE6</accession>
    <name>A0A1B7YIE6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="16">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_03884</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="16"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160105.1">
        <property type="nucleotide sequence ID" value="XM_018298859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIE6"/>
    <dbReference type="GeneID" id="28862966"/>
    <dbReference type="KEGG" id="chig:CH63R_03884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03884"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447774" description="Carboxylic ester hydrolase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="832"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="607"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1027" mass="112865" checksum="213C1F10264E4A62" modified="2016-11-02" version="1">MLPLLLLGALAPNVQAVALSNSNTTFEQQCSSFATSLKISGANATAVEYVPAGTTLQFPNADPSCGRASQTATANLCRVTARIATSPRSGIKFEAWLPEDWTGRFLSTGNGGLGGCIQYEDLDYATSLGFAAVATNNGHDGMSGAPFLNNPDVIEDFSYRALTTGVVVGKDVTKSFYSKPYTKSYYLGCSTGGRQGFKQAQAFPENFDGIVAGAPAFSFNNLTSWSCHFLPLTGQQGADTFIPMSMWPAIHDDILDQCDELDGAKDGFLEAPDLCDYKPESLLCGVGSNQTDGCLTQKQVETLRAIYSPLLDASGDLVYPRMQPGAELTGAPQTYFTGQPFGAADWFKYAIYNDSNWDPATVTSEDYVRSSSLNLFNIETWDGDLSPFEQRGGKILHYHGLVDGTISSDNSPRYYEHVAQTMGRKPAELDEFYRFFRISGLAHCSGGTGAVYIGNQARNAAGLEPEENVLMAMVRWVEEGVAPEHVTGTAFVNNTVSAGVDYKRRHCRWPTRNVFKGPGDFRDENNWDRDVAEGSLWLDPELSKLDFKARDNPPHTRDTETRRHITKKLAAANTGYLPEHIFEPHPTHPATLSLACFCVETMAEAQKDLESQRKPSDERTPLLGTPAEYEANQQEARDRSGHANDDQDREDAEQVPLIAPQDGEETKKRTTGWWLWRAFWAVLAIFFLAIFIKGWVDAKDTNFDLKAALKRALGGGLSGAAAMVLQVLTLMPIRTIMNYQYRFGSGFREAISVLYQDGGVRRYYQGIGPALIQGTSQQVVFRRGGVVPGYDFQSVIRLTDETIGPVSRFGDTAANAGILALLESNSFLNQLPTLIKTIFASLCAAAFRMILTPIDTLKTTLQAQGAKGTAILRQRVKTHGVGSLWWGAFATAAATFVGHYPWFATYNYLSANIPEPEKGQIFLWLLRLAFIGFCASVISDSVSNSLRVVKTYRQVNDTQVSYCQFLRPALSLRSSAKAAKIVIQRDGFLGFLGRGLKTRILANGLQGILFSILWKLFLDLWEKKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJJ7</accession>
    <name>A0A1B7YJJ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-sorbose</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160581.1">
        <property type="nucleotide sequence ID" value="XM_018299335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJJ7"/>
    <dbReference type="GeneID" id="28863442"/>
    <dbReference type="KEGG" id="chig:CH63R_04360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04360"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="452" mass="49460" checksum="6888E710FAFA2013" modified="2016-11-02" version="1">MKFKVSLGVSRASCEPGRTNEPPRAPQCHPTDTDVIKCVDHPSFKVSGRRRNIVWQSAAKQYADVPRTRGGWKMPTTFEHARAPPLSQHQTNIGGSTVSHDSESVRRTKGIIADVAGNPAFQRVAWGISHIEDEPYMMAPGMDHLILVGACYVDTVMSVPHFPEEDSKLRASSLRVRRGGNCPNTVEVLQQLIAEDPPKSPPSRPLRIHLVSPLPERQSQATAQIVASLCPTTGDASQPKDEDDGPPAVSFDHCLFRKGHQAPASSYILRSEAAGTRTIVNHNSLPEMTADEFLRVAEAFKGRGRTWWHFEGRIPETTLKCIRLLRRVLDDVTISVEVEKPGRPGLRELAAEAEVVFYSKSWAEDCGYTSAEACLRSEILPQASVGAGDTFVAGMLYGLICQSDTWDTADKLGYAVELATLKVQREGFGGLGNDIQSRVGGGSSVSDQARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJK6</accession>
    <name>A0A1B7YJK6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160778.1">
        <property type="nucleotide sequence ID" value="XM_018299532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJK6"/>
    <dbReference type="GeneID" id="28863639"/>
    <dbReference type="KEGG" id="chig:CH63R_04557"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04557"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="277"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="663" mass="73839" checksum="FC121488C8D411BC" modified="2016-11-02" version="1">MIKYTVRRLPKPSRIRPPSYVLRPLIAPPRQPAPFSPRYTSFKVQLRDYQEECIQSVLQSLKDGHKRLGISLATGSGKTVIFTQLIERIQPRRGRATQTLILAHRRELVEQAARHCTNSYPNSSVEIEMGSIHASGTADITIASLQSITSGDRLSKFAPEGFKLVLVDEAHHIVAPGYMRVLRHFGLDIKRADSPALVGVSATFSRFDGLKLGAAIDQIVYHKDYVDMIGDKWLSDVVFTTVESTADISRVKNGANGDFQQGDLSRVVNTDQINDITVRSWLARASDRKSTLVFCVDLAHVAGLTQTFRKHGYDARFVTGDTPKVERSHMLEAFRKGEFPVLVNCGVFTEGTDIPNIDCVVLARPTRSRNLLVQMIGRGMRLHEGKRDCHVIDMVSSLETGIVTTPTLFGLDPGEVVNKASSADLNDIKDRKQAEQLRQQHAYSDARDPQPTAVTSVTFTDYNSVFDLIEDTSGEKHIRAISQYAWVQVGADRYVLCAPSGSFIRLSKLESDAASKTEQQPPLWLAVEVRALPAGVAKSPYAAPRELLKATTFADAVHGSDKYASETFPHVFIHRYQRWRKGPPTPGQIEFLNKLRPKEEPLTADDIDKGKATDMITKIKHGAKGRFAGIMTEKRKVQRQHHKISQHEARARHEKVSVGPVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJT8</accession>
    <name>A0A1B7YJT8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_04586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160807.1">
        <property type="nucleotide sequence ID" value="XM_018299561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJT8"/>
    <dbReference type="GeneID" id="28863668"/>
    <dbReference type="KEGG" id="chig:CH63R_04586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04586"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="658" mass="75248" checksum="3C5E7A9D46A3F5F9" modified="2016-11-02" version="1">MKTQWKDLPPVPNSQEFLDIVLSRTQRRLPTQIRSGFKISRIRGFYTRKVRFTQETISEKLGQIIESFPRLNDIHPFHKDLINTLYDADHFKIALGQLSTAKHLIETISRDYVRLLKYGQSLFQCKQLKRAALGRMATLIKRLKDPLVYLDQVRQHLGRLPSIDPNTRTLLITGFPNVGKSSFLKSVSRADVDVQPYAFTTKSLFCGHFDYKYLRFQCIDTPGILDHPLEEMNTIEMQSVTAIAHLRSAILYFMDLSEQCGYSIQAQINLFQSIKPLFQNKIVFIVINKIDVVKPEDLDTATQAQLQGLLKSGEVEMLQLSCNTQEGVQDVKNTVCERLIAERVSQKLNAGTNSSGNIGGRLADVMARIHVAQPGTAPLQTFIPEGIKNLKKYDREDPERRRLAKDVEADNGGAGVYSVDMRQDWLLKNPEWKHDKIPEVWNGQNVYDFIDPEIDAKLQALEEEEERLEKEGYYESDEELDDEEEADVLSKAELIREKQALIRNEAKMKKRLKNQAIIPRKSQKVPLSQMDDALDQLGIDTTDIVNRARSQSRPRGRSAGRSRGGTEDVDMMDMDATPKERLRSHSRARSQSRAPIVNRREDGVQDSEDRTMADRLAKLSQKKRNRMARQGEGDRHTTVSLQRHLVAGKRGLGKNQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJU9</accession>
    <name>A0A1B7YJU9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160691.1">
        <property type="nucleotide sequence ID" value="XM_018299445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJU9"/>
    <dbReference type="GeneID" id="28863552"/>
    <dbReference type="KEGG" id="chig:CH63R_04470"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04470"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="372" mass="41163" checksum="3A9A32947CC910CB" modified="2016-11-02" version="1">MDHTTTAAVDGGDGAAEGLMNMTNAASPKSASQHEHHLVYHRQQPLPPPFPHRRTSSGANFLSKLPFMRSHSDGKQQQPHEAIEDASRSPPTSMSTITQQQQQQQQKSRRRKGSLRKVALLGRGAQRERKEARQLTIDTSHTVSRVMDGAFARSHTTPEHDPLGLNISDLTPRPSMEGYASRSSVAESSLPTSTSLPQPTDTESVITSPTISYTSTTDEDDVLHIPNHIPSPLRPDLSLSSGSDSYFGNRSRRRSLLQAKSPLSYSGLSTTPLPPNDAEWDYSETEWWGWVVLIVTWIVFVVGMGSVLGIWSWAWDVGTTPYAPPELEDDPTLPIVGYYPALIILTCIMAWVWVIVAWVGMKYFRHAKISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKQ2</accession>
    <name>A0A1B7YKQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161113.1">
        <property type="nucleotide sequence ID" value="XM_018299867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKQ2"/>
    <dbReference type="GeneID" id="28863974"/>
    <dbReference type="KEGG" id="chig:CH63R_04892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04892"/>
    <dbReference type="OrthoDB" id="5208908at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23539">
        <property type="entry name" value="MFS TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="343"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="540" mass="56528" checksum="B2BEF4BCF6EECF16" modified="2016-11-02" version="1">MDVKDFQITPSNAIGLESLRLPPSSSDVSVDDKQDAPINASAPVPPTLSDALIREAHTQADSGSTDVNDAKLRRRARWALFVMAFFMGDVQDGIGPFLGVYLQQHGWSPGLRGSVSTASGVATIIATAPIGALIDATKYKRLLVSAFALLVGVSQGLNLLTTHPALVFSTQIVSAVAGTSMMPLLVALTLGVCSRHPGGDGAAKGKNKHSFRALNGRNQAANHAGNMVSAGLAAVLGERFGLTAVFWLVMAFCAATMGSVLLLPERAIDHAAARGGPSVDNDMNTTGGPQDMQERDRSGTGEEAERGGASTTHTREAPIANPKEKKKNRFLNSTLGVLLKNKPLVVVAVTVFLFHLGNAAILFLYGQALVAAGEGNPASTTGLTVIIAQGTMVIVSVLTSWLAGRSGYWFAVLLSYVALPVRAAIAGRFIKSWGVWPVQILDGVGAGIQSVAIPGLLAVMMAGTGRVNVTFGIVGGVTRQTGAAISHSLGGWMAEARGYSFALYLSGVFPLVSLAIWLGFYKMLRPVMDRKPSEGVMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLK4</accession>
    <name>A0A1B7YLK4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161331.1">
        <property type="nucleotide sequence ID" value="XM_018300085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLK4"/>
    <dbReference type="GeneID" id="28864192"/>
    <dbReference type="KEGG" id="chig:CH63R_05110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05110"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601755" evidence="2">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="230" mass="22442" checksum="0591A6F8CE71B846" modified="2016-11-02" version="1">MHSSTLLAAVIPAVMAQYGSGGDSSSSSTASAAASSSSSIAGVHVVKVGDGGLTFEPNSLTAAVGDVVEFHFYPRAHSVAQSAFDSPCQPLANGTATGFFSGPVQVASGVGAEVFTVKVTDSNPKWYYCATGQHCQGGMVGVINPPSSGQRTIEQYAQAAAAAQANVAPSATGGGTLGSAATGSPSSASGTPSASSTTQPSAGIEARGDVRWGLLSLGVAAAGFVGGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM68</accession>
    <name>A0A1B7YM68_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161663.1">
        <property type="nucleotide sequence ID" value="XM_018296847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM68"/>
    <dbReference type="GeneID" id="28860954"/>
    <dbReference type="KEGG" id="chig:CH63R_01872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01872"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="101" mass="10346" checksum="DB545B6FA5174C76" modified="2016-11-02" version="1">MPMFPSAAAAPAAGMGGDAFVDYGPAPDQDLGPGWVADPNFRLEQVPAGRDGGGGSGGGDRCWPPLFAAFRGAPRGAARDPRREAAGERQADMNDDEMEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMR4</accession>
    <name>A0A1B7YMR4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongation factor Tu GTP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_01940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161731.1">
        <property type="nucleotide sequence ID" value="XM_018296915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMR4"/>
    <dbReference type="GeneID" id="28861022"/>
    <dbReference type="KEGG" id="chig:CH63R_01940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01940"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="185"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="641" mass="69709" checksum="BEBEA555433F6222" modified="2016-11-02" version="1">MTSKTIKSLPHEKRKGEAALSDFADYVEKQQALRYPSSKSADISKVPTAAPEHQHAELDELFDNLDLAEATSGVRLKDLLLGTDGGTLQQLEGVVQERILEGHGEAIFELGFESNGESMALTLSQWNDAYTRLKDAAKRIRADCQTLITKNVDGEMDASSAKPGKENHCSGKILIRQAPATVEDVIETRIAVVGNVDAGKSSLLGVLVKGDLDDGRGRARVNLFRHKHEIETGRTSSVGMEILGFDTVGEVVTSETPGRKLSWEEIGKRSAKVITFTDLAGHEKYLRTTVFGLLSSSPNYCLLMVAANNGLIGMSKEHLGIALALNVPVMVVITKIDICPPQILEQTISQITKILKSPGARKIPIFIKDREECINTATQFVSQRICPVFQVSNVTGENLDLVRTFLNILPHHGRYDSDAPFEFHVNDTFSVPFVGTVVSGIIKSGVIHAGDNVLIGPDSLGQFTTTSIRSIERKRLGVPAASAGQSASFALKKVRRKDVRKGMVVLPKLEGQPAPKVHREFIAEVLILSHATTIKTKYQAMLHVGPVSQTCAIIDVDRPYIRTGDRATVAFRFVQRPEYLAPGDRLLFREGRTKGLGIVKSVGYDPNKPLYPHGDDSAQGEDGAAPDNEGEKKPANGQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN29</accession>
    <name>A0A1B7YN29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161968.1">
        <property type="nucleotide sequence ID" value="XM_018297152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN29"/>
    <dbReference type="GeneID" id="28861259"/>
    <dbReference type="KEGG" id="chig:CH63R_02177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02177"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="33839" checksum="2BEE241F3291BA5A" modified="2016-11-02" version="1">MSVLVLGAGELGTAMLKALTAHPSRPRDSPVSVLLRPSTITSSDPTKRDSLAQIAALGVSVEAGDVVHDPVRDLARTFARHHTVISCTGFVGPAGTQRRICEAALLAGVCRFIPWQFGVDYDALGRGGPQPLFDEMLDVRDALRAQADVAWIVVSTGLFMSFLFVREFGVVDLEARTLRALGGWDVEVTLTGPGDIAAMTAEVVYEPRGIPGDDRNVVYVSGDTVSYGRAADLVEQRFPGVEFAREVWDVEALAENLARDPADTWNKYRAIFGAGKGISWPTEKTLNHERGIELEDLETYLGRMETPAALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN63</accession>
    <name>A0A1B7YN63_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161899.1">
        <property type="nucleotide sequence ID" value="XM_018297083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN63"/>
    <dbReference type="GeneID" id="28861190"/>
    <dbReference type="KEGG" id="chig:CH63R_02108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02108"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="519"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="843" mass="93243" checksum="44B79DC80AAFD214" modified="2016-11-02" version="1">MMEASHPAAGWENVGDKWYRKVQLYTEVFDQDLDLDNHIVAGAPYGGAIALLRDDTKIQAYRANPGGGGGGASSSKPGIDIYSYAGKLLRRIPWEQGSGSIKGLGWASVAGGEEKLLVATTDGTVRVYDLQGEFTQFSLGNGADESGVISCRFYESGMVALLGNDTFVSVTSYTEPRPRLLATPPTDQGEIHAWAVVAPDHTLSRSVEVLLSIGETVYVIDAAECEDRFLDLGPFSHISVSPDGRLIALYTKTGKAHVISSDFQERRVEHDSQSKIPPKYVEWCGTDALIAWEDEVHIIGPDAATAEFFYDGRVHVVSEHDGARLITNDVCDFLERVPHATEEVFGTRAESSAASILLDAVGQLELQSPKADDYIQLIRANLTEAVDTCVTAAGREFSIHWQKQLLKAASFGKSVLDIYNSDEFVDMCETLRVLNAVRFFEVGLPLSFEQYQRLTPEGLIKRLINRHEYLLALKIAGYLRLPTDRIYVHWASAKVRSGAEDDDTICRLVVERLSGKPGISFEEIARAAYDEGRGRLATELLNHEPRGGRQVPLLLSMEEDELALDKAVESGDTDLMYTVLLQLKKKLPLAAFFRVINARPAATALVESSAAREADNALLKDLYYQDDRRVDGAGVFIHESLHQPDARTASDKLALAAKLLSDSREAAFEVHALKEAQTLLKMQEAFDRDLTDTFTGLSVNETMFKLIRLGYHKRASKIQSEFKVPDKVAWWIRLRALVAKRDWNEIEELAKTRKSPIGWEPFFNLTLQAGNPRLAAVFVPKCTGLEPGTTITMYEKCGLRVKAAEEAVKLKDAEAWGRLLEAAGRGTQEGRDIERIGSAVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNL3</accession>
    <name>A0A1B7YNL3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162172.1">
        <property type="nucleotide sequence ID" value="XM_018297356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNL3"/>
    <dbReference type="GeneID" id="28861463"/>
    <dbReference type="KEGG" id="chig:CH63R_02381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02381"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="456"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="745" mass="81738" checksum="6F5500DA72697EFD" modified="2016-11-02" version="1">MEFIGLQMMVTLRQPLGTMLKGTVSAIEPGTSLTLSNVFTIGTNHWLPRVIIDAANILELSESREEVVPNTFTAPGVSPVPAPVINQPAFADPAILSMGKRPGSDMRSGSEKQSLPEATPQPTLAETRDPRPGQPGVLSSVHLTGGPRDDVVSLSETLQELDVEEPTPTARRHVPESSAVPQVAHEVHEVQSQSQKRKNRRREKQRAPRNGVMDETIPEITPMRGNAANRGKGWRQTPMLQSSPSFQPFNSLKRGIKGKKDLPENGWASEDVTEEMAEFDFENNLAKFDKRTIFDQMRKEDLIDDADRLVSHNRRPKPGTAGGKNFHYSENVLDIPSASSNAHQDFWNSEADDAANGVDRLSGRDVRSAQSSRRAESKSGPSRRSQSRKASAQLPSQPLNRVNSNVRLNRQPQALLRPQDSPKNILGANHMQHVTQSGFYLVPSNRRLETVSALQMLNLENIAANEIGLTEDMMAENAGRGIAEVTLRALEDPAIQVRFGTGGANAQNNSLATSATVVILAGNNKSGIRAISAARHLRNKGLNILVCVVGVERERDLLEDMRQQIRVFRNFGGRVHSKIELFEQLRKTASTPATSVTLIIDALLGLAISFEELRTGDQATVYELIEWANRNEAFVLAVDVPTGIDPSTGKVSIIDGGRLYVKPRYVVAMGAPKKGLLEAMAPVSDSDPTGTETAVAEEEDWKLFIADMGLGATVWKKAGTKIRRGIDFDDKWVLQMRYQPALSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNX6</accession>
    <name>A0A1B7YNX6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arca-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162278.1">
        <property type="nucleotide sequence ID" value="XM_018297462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNX6"/>
    <dbReference type="GeneID" id="28861569"/>
    <dbReference type="KEGG" id="chig:CH63R_02487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02487"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="482" mass="53986" checksum="286A1CB2EEDE9E31" modified="2016-11-02" version="1">MESQREVSIADDTKKRRRGGQRKKTERHTPCDEKKPVCGNCERLRLSCRPFEPIKQSAWSAPDGTNHLTRRPRQHFQQQQQQQNLFQADEAEASFPGTLDSTGVLFTAHMPGPPWNTTAGTSPSPPKQTASIPHPQHPQQGVGVVVVEDSNGGNGGSSSTSDIISRAQVTLTAEMVHLLTTYRTSVATWMDIFDYGCAYQLEVLRRCMTSKLLVRSVCAFTAKHLSLLPSGDVWVAPATRYYGESLRGLIGYIGTGSVPEDVLTATILLCSYEIIATQGEEHQRHLAGAKLLILNRGVSASSVGLDRANFWIYIRHEITVALFNKTTLQISPRDWRVNWRETEVEEDVLANQLLWLLGRAIDVVFRQEQSVFTTTATLCDERQEIYAEVATWFRCWSPSFKGVKYGEPDDQGFSKFSAIIGGVLRSRADQADALLLSPAAKHITGISRKIRLWNMLDDIETRLGFRTRDQVKKLKELVETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ90</accession>
    <name>A0A1B7YQ90_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162727.1">
        <property type="nucleotide sequence ID" value="XM_018297911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ90"/>
    <dbReference type="GeneID" id="28862018"/>
    <dbReference type="KEGG" id="chig:CH63R_02936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02936"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="137" mass="15259" checksum="3C2FE3FA84F96B87" modified="2016-11-02" version="1">MSLDLDVEGRRAHPHSPIITGHILCPGFRTSTNSGAGGGEGLRARHLQSHLTRARGNRRLRSGDHESKRTNVEILGTRESCRNSCSLWVEHTPVPRARHLYRFKGIEVLFRALKPVRHSTLSHIKTTAAANCEELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ95</accession>
    <name>A0A1B7YQ95_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162736.1">
        <property type="nucleotide sequence ID" value="XM_018297920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ95"/>
    <dbReference type="GeneID" id="28862027"/>
    <dbReference type="KEGG" id="chig:CH63R_02945"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02945"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="34124" checksum="9A9137846DEF0711" modified="2016-11-02" version="1">MSTSAVTKKLVVCGGNGFLGSRICKYAVARGWDVTSIRYAHTIGASHSPSISLLSSSPRLTRSNSRSGEPKWSAVTSSPAPPQWAHQVSWERADMLSPVTYAPLLKGADFVVHSLGILLEADYKGVVSGQESPISGLQKAFAPIKDRGVDPLKTSSEGGDLKPPNPKDQFTYEVMNRDSAIALAKQANAENAKAFVYVSAAGGAPVLPARYITTKREAESTIASEFPRMRGIFPRPPFMYDSSRKFTLPLAAMTGAGALFNRLTGGVLSGFMGASGVKPLPVETVAEAVVEALDDVKVQGPIEVPELEELASKGWRKTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQX6</accession>
    <name>A0A1B7YQX6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 10">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_03167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 10"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162958.1">
        <property type="nucleotide sequence ID" value="XM_018298142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQX6"/>
    <dbReference type="GeneID" id="28862249"/>
    <dbReference type="KEGG" id="chig:CH63R_03167"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03167"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000001">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF51">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="263" mass="30253" checksum="D2163D102DAD8306" modified="2016-11-02" version="1">MQEQRWWEKKGRTVPAPSCATSSFSHIAHRRASDKPNPKMADQDIEHYLKQTHDRVFENNRRWAEEKKKQDPNFFVSLSEGQSPEYLWIGCSDSRIPAEQITGLEPGEAFIHRNIANMVNNIDLNVMSVINYAVRHLKVKHIVVCGHYGCGGVKAAMTPKDLGLLNPWLRNIRDVYRLHEAELDAIADEDARYDRLVELNVVEQCRNVIKTAAIQQSYAKNKFPIVHGWVFGFNDGLLKDLKIDHKSMLHDIQKLYHLPGADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRH1</accession>
    <name>A0A1B7YRH1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163140.1">
        <property type="nucleotide sequence ID" value="XM_018298324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRH1"/>
    <dbReference type="GeneID" id="28862431"/>
    <dbReference type="KEGG" id="chig:CH63R_03349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03349"/>
    <dbReference type="OrthoDB" id="4848569at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601860" evidence="1">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="321" mass="36573" checksum="E3E9B9D94FE76B16" modified="2016-11-02" version="1">MTLSTFHADLYLFAMADVCVSQQCGLCCFKLYNGEDIIAGACTATLCCSRGVDIQLRTRKVGYQLGCTIANSRTTVIGMSQRIWAHFTTFEGVDYIAPLNNAADHLHAELIFEPDPARSVKTVYIAENHLGARQIIFHHSETPLALEPCEELWWRNLHLKGPTKLVLQSDLEESPPPNRMSSLLLNDSGIIGYAFYWKLRLVSMHAVTSEQDLSFYDRDHDGLWIYVPLLERELITEIWIRGQTKWDMSLILKTSRDRVVNVGPHLTIMPWTPVRLLERPNQQTASWILFELSRVGIRNMGFAGGWLHHFSSSTNVQEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRW1</accession>
    <name>A0A1B7YRW1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate:fumarate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_03503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163294.1">
        <property type="nucleotide sequence ID" value="XM_018298478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRW1"/>
    <dbReference type="GeneID" id="28862585"/>
    <dbReference type="KEGG" id="chig:CH63R_03503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03503"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="35075" checksum="849210E7CA44D1E7" modified="2016-11-02" version="1">MASKVKQDGKTPTSAATNLIAGGGAGMMEALACHPLDTIKVRMQLSRRARQPGAPKRGFIRTGVEIVKKETPLGLYKGLGAVLTGIVPKMAIRFTSFEGYKQALADKQTGIVSGQATFMAGLAAGVTEAVAVVTPMEVIKIRLQAQHHSMADPLDIPKYRNAAHALYTVVKEEGFGALYRGVSLTALRQGSNQAVNFTAYSYFKEALKNYQPEFERTTLPGWQTTLIGLVSGAMGPLSNAPIDTIKTRLQKTPAEYGTSAWSRIAKISSDMFKQEGFHAFYKGITPRIMRVAPGQAVTFTVYEFLKEKLERSNLAFTGGNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSW4</accession>
    <name>A0A1B7YSW4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163656.1">
        <property type="nucleotide sequence ID" value="XM_018295294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSW4"/>
    <dbReference type="GeneID" id="28859401"/>
    <dbReference type="KEGG" id="chig:CH63R_00319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00319"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="881" mass="98945" checksum="0CB3CA85B9E75B12" modified="2016-11-02" version="1">MSATPVPPEDQARLLEDALVAVRQQTALMRKCLDTPGKLMDALKCCLGPKQYYELYMAVFDALRYLSVHLRENHPVNHLADLYELVQYAGNIVPRLYLMITVGTAYMSIPDAPVKELMKDMMDMSRGVQHPIRGLFLRYYLSGQARDYLPTGDGDGPEGNLSDSINFILTNFVEMNKLWVRLQHQGHSREREQRTRERKELQLLVGSNIVRLSQLVDLETYKSGILAPLLEQVVQCRDVLAQEYLLEVITQVFPDDFHLHTLDQFLGAVSRLNPHVNVKAIVIGLMDRLSDYAERESKDETEGDRAKLEEEALAALLEKTSLKNEGRGASSAPGGHPDANDEPGQAADLSLNGVNPTSENEARAAEDLPPPEEPTPSIADTDATAVNGEGVAPEKGIPENVQLYEIFFSQVKNLVEAQHLPIQDTIALLCSLTNLALNIYPERLDFVNQILDYATIKVRENANNADLHSPPAQHSLLALLQAPLNRYLSIFTALSLPTYVPLFQSQSYPTRRAVAGEVARTLLRDQTRISTPNQLENVLEVLKVLIKEGSQASSNYPGVAQRRAVETDETMEEQGWLARIVHLVDGEDNDTQFRLLQMTRKAYSEGNERIRTTTPPLITACMKLARRFKAREHYEDNWETQSNALFKFMHSALSTLYTRVNGAGAAELALRLFCASGQTADMAGFEEVAYEFFAQAFTVYEEAISDSKAQFQAVCVIATALHQTRNFGKENYDTLITKCAQHGSKLLRKPDQCRAVYLASHLWWATPMAVYGETDETGLYRDGKRVLECLQRALRVADSCMETATSIELFVEILDRYVYYFDQQNAAVTTKYLNGLIELIHSNLAGNQQDSASVENSKRHFYHILESIKGRQYEGVVLYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT32</accession>
    <name>A0A1B7YT32_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_00380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163717.1">
        <property type="nucleotide sequence ID" value="XM_018295355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT32"/>
    <dbReference type="GeneID" id="28859462"/>
    <dbReference type="KEGG" id="chig:CH63R_00380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00380"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="440" mass="47331" checksum="315AE8E1EE4175C0" modified="2016-11-02" version="1">MVTVGLSLTAAAGAIEVTWDDDESIKSAAGTAAYGLVKYYTGNNTGWEAGAMFGTLVDYWWLTGDDSYNAITTQALLHQAGDDDDYMPQNQTLTEGNDDQGFWAMAAMSAAEHKYPNPPEGKPQWLALVQAVFNEYVSRWDTEHCGGGVRWQIFTWNAGFDYKNSISNGCFFNVAARLARYTGNTTYSDWAEKVWDWQTDVGLLTAEHEVLDGVHFEGKCPSSTDSTKWSYNAGIFLYGAAVMYNVTESDTWKTRVDGMLEDISQHFVQNETIYEAYCEPTAQCSQDAQSFKGYLARWMAATSQVAPHTSDSIRKLLLSSGEKAAKACSGSPASGFKGHPGTACGFSWLSETFDGLVGVGPQMTSLQTIMYNLVRSADGPVTVNSGGNSKGNPDGGKSDDGSGTAKKTFAEITTGDRAGAAILTILVTGGVVGGTAFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTB1</accession>
    <name>A0A1B7YTB1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="6">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the annexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163645.1">
        <property type="nucleotide sequence ID" value="XM_018295283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTB1"/>
    <dbReference type="GeneID" id="28859390"/>
    <dbReference type="KEGG" id="chig:CH63R_00308"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00308"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000002">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0041">Annexin</keyword>
    <keyword evidence="3 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 6" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="464" mass="50702" checksum="2401F970F8C66926" modified="2016-11-02" version="1">MSYPGQHGYGAQPHGQGYGQQYPPPPQAGYGGSPYPPQHGQYPPPAGPPPGQYGAPPPQHGGYYQQPPPGQYPPQGGHYPPPAGPPPGQYPPQGGQYGAPPPIPPSPYGHSPAPSGYGAPPPGPPPSQQYGAPPPQHFGPPTPASLGYGPPQIIQWDGSPDAAAARAAMKGFGTDEKALIRCLATKDPLQIDAIRTAYHRNFKRDLEQDIKKETSSWFQKGLVSVARGPLRSDIYNLYEAMDGLGTKESVLNDVLLGRSNADLQAIKSAYQQTFKRRLEDDVKGDLSLKTERHFLIVLGANRAEDSAPVVPQQVDSDVMELYKATEGKIGTDEMLVCSILSTRNDNQIRAINQAYEQKFRRKLDDVIKKEFSGHMEDALLFQLRHAVDKYMHAAQLLEDSMAGLGTKDHLLVARVVRYHWDREFLANVKGAYQARYKRSLAGRIKGETSGDYQRLMLACIGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTZ6</accession>
    <name>A0A1B7YTZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164000.1">
        <property type="nucleotide sequence ID" value="XM_018295638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTZ6"/>
    <dbReference type="GeneID" id="28859745"/>
    <dbReference type="KEGG" id="chig:CH63R_00663"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00663"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="761"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="832" mass="90162" checksum="3F5175068EFFD421" modified="2016-11-02" version="1">MSVTTTTATAAHAPTHRSLAHPPRTLRKATSYTSNFVPSTTASSPSLNSLYNTHSRLTPSHQTLPRKSSLAALTPKSLASIPDVSESYAYNSVLAESPDRKMPPATPGKAGNDFVVGDVVEVPGNMFGTVRFIGSVDGKKGTFAGVELHPEFSQRGKNSGEVEGVSYFTTTLPGAGIFLPLNKAVRRDSPPGSSYGAFPHTPTASTIGGLKVGTQNSMNYTPPTPSVPMFSKSVGPGRASSPALKKSISRPSVRPESPVRKLQMTPGPRPSLATPGKMPSKYSSPAVNRFAQSVRGTSGDPSKAPRLDRKPSIGPRSASALGQTSMFDEDPAPPATLQRTQTNGSTNSVSSYNSKFRVPSRAGAGSRAASRAQNDDEIERLRTTLEDRERQLRDQASTLAEMESSLTELQTLMESSDLGAPKRNSIDDKDTAQLRALVKEKNEKIAMLTAEFDTHRADFRSTIDTLEMASAETERVYEKRIDELMIEIRDLESRTDDVDSVARQLKQLEELVQELEEGLEDARRGEAEARGEVEFLRGEVERTRTELRREREKTSAAMNGSRGPTGGGDRPSGSKELEQKEDEIRGLKAIIHSLSRDSIPGGGADKSEDPSVRENALARERLERELAELHSVVKDKSQREEELEQELEMLRKGGATTQQPGPMTNGDAHRSSLRDSRDTVVLMRNSEPQPPTATHKRVRTLDTMPESDAYSSVTDNSTLWCEICETGGHDILTCTNMFGTESAKNNGDASKAVKDAIKADMQPTPAKDKPAPLSPIKAKTSAPPSSIKMLPNPMETGPVAGKETGVVDDSKWCAVCERDGHESYDCPFEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV43</accession>
    <name>A0A1B7YV43_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164321.1">
        <property type="nucleotide sequence ID" value="XM_018295959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV43"/>
    <dbReference type="GeneID" id="28860066"/>
    <dbReference type="KEGG" id="chig:CH63R_00984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00984"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="245"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="985" mass="109119" checksum="38C19C35A37013A1" modified="2016-11-02" version="1">MASPPDSASLGSCSRSSSVRINRKTSCATSNPPSPGSQHESATSEDVFEDVDLSSGLDGLHIDGVEVWDTLSNMAAFGLEPNNSNSYDSYDNLVPFPQISLDDSDDALELSDSDMSPKQGPFHKWMRNLHRRAKQRPRPMNADGTLPWKLLDSADRSALSRRTRHRRSSSGSSFGFVAAVKSASVSLASGSAINRPRGNSRHSLAPSRTERSSRASFTAARFSEDSCHVEWPAEVDPLATERALQRRRILEELISTEESYIGDVRFLMNVYITILASLPTLPMGLRSSINRNLTDIVELHEELLGELHRVVPDSEYTQIEIPPSPSRPTGRRHQRLRSLDSVPEDDGRAISWLQEVPGMVSEAQIAGDVAKVFSRKMNRFFIYEEYGAKYEMMIKDVASAHRTMPQWDTYQRGIEALASSLGPASTHADLSKKSLTIGDLLVKVSSISLPLPTKVLTSPQPIQRICKYPLLFAELLKYTPVMDCPNSHMEVESALLRLREATAEINRATNDRRMKSTLEKTWILQDRLVFPEQLDAASKNRIRSFGHVDLCGALHVCWQTKEGAKGQYMICLLYHNVLCLASASKVDQIYTIQACINMGGIKIEETDNGRGLQCHTAPFSWKLVFECDSQLYELLMTACSPREQEEWRSRLTNAAKGEQEQVDPSLYSSMFLSMKSLGTMFRKPGTVARRISIHRATTVGPKSPLCQVILKNTSVMRDNSDAASNSSINRSQSLLTTNPRIPIIAPPRGERARLEALMSDIWSRDILPFPGMTGRSRSEHLVRSSASTMMRKLSVASIASSFAKRSNSVASLGKLVAEDDTGDKGSTLQGHPSKLCRAESSNTEHGPDDEVENTKGARLPKIDDDVEVTSTVSAPATPMLLPSAIFVHADPVEQLWSGHDGRAFSNVLPSRPTVLRTASGNNLPRIRRDPITPKMSPCPSERDEKDLQINAAKAPRLSHKPSMRWGRVGTLNRDDLVQGIRSFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVD6</accession>
    <name>A0A1B7YVD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164500.1">
        <property type="nucleotide sequence ID" value="XM_018296138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVD6"/>
    <dbReference type="GeneID" id="28860245"/>
    <dbReference type="KEGG" id="chig:CH63R_01163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01163"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="116" mass="12997" checksum="13F7D5CED3464337" modified="2016-11-02" version="1">MPVKGDDDGDDDNKKESLLQPANTPRYFAHVDRLGKENPGKKTKEHEIVHSLRLVAGFPSSLRMDFALFPVLVLSKSNLRVANQVNVWMTEPSTPPLRTPLLRLSPLPFQENPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWD9</accession>
    <name>A0A1B7YWD9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164705.1">
        <property type="nucleotide sequence ID" value="XM_018296343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWD9"/>
    <dbReference type="GeneID" id="28860450"/>
    <dbReference type="KEGG" id="chig:CH63R_01368"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01368"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="227" mass="24317" checksum="DD84AA9265192DC6" modified="2016-11-02" version="1">MASTAPTGTRRQDKYDNDDSQGAERSRGRQWNVGLSASVGFPSSRASQQPGPITSRSFHVVVVVVSQGPGPPHSLLLLPTAISKFFEVPFHLPSPTNQPPQCASHVPNRQLCVRRAQKKSRLPSAARPESPADTREFSIESPCIASGRDFPRSSYDTNLRFPGSPPIVAADVLLAFAAAISLHVGLVLALFPFANLGSSLVFLDLDLNLDLDLILNLGSLARSSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWL9</accession>
    <name>A0A1B7YWL9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164950.1">
        <property type="nucleotide sequence ID" value="XM_018296588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWL9"/>
    <dbReference type="GeneID" id="28860695"/>
    <dbReference type="KEGG" id="chig:CH63R_01613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01613"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="307" mass="34185" checksum="09629235501F3093" modified="2016-11-02" version="1">MSWMDSWSRPSKSQATPAPFYLLPNGDATSYCRTCGRVISSRKATAASKAPKTAETKTEPKYCSSRCRGQKPGRLDKEIEQAFVRFLQGEDEVEGSKAKKVKGDTRILVACDAVESKVFGDRQDPNKVYGRKKNRASRVIGGNGASDEDEAIDLGERSQQRPDGDTNTRNDNDNDNDPGAEVIDEMLGLDRSKSAELDPHVQASLSVRSGTRVRPPQTRSQVNGSVGGEKGRAERVEETDEMREKRAEGQRRAHEREMVRCAARRGVVFGFLVDGRDERRKCEAVMQGKVVEPSYAKGDWAVRWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXD3</accession>
    <name>H1UXD3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cra-b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04982</name>
        <name evidence="4" type="ORF">CH63R_04168</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000488">
        <property type="protein sequence ID" value="CCF32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160389.1">
        <property type="nucleotide sequence ID" value="XM_018299143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXD3"/>
    <dbReference type="STRING" id="759273.H1UXD3"/>
    <dbReference type="GeneID" id="28863250"/>
    <dbReference type="KEGG" id="chig:CH63R_04168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04168"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016581_1_0_1"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="600" mass="67362" checksum="9772F2F6A9675568" modified="2012-03-21" version="1">MIPEKPLPCSDEFASPDAYVAALLEFATTTDIFQILCGGVHVLDFFTNESGLFAQILPQEWQPFLLSYDTGALLDLLMRDDLDALPLDSMDPAPPASFLEYIRSVRRLSLRRTFSPSSQAEARPPPKLSRSVAVGMKPKKVHEVSHFARYVDSLAGAISSRWGKETTHFVDFGSGQNYLGRTLALPPYNRHVVAVEGREHNIDGAKGLDVLSGLASKEVVMRNKKLWLQMQADRLGTEAVRNVPSKLSTDAVEDFDFRPIKELEPQYNRALGKGSVSYVVGRLESGDLTEVIGRIEKEVLPEEEDKELKMMAVSIHSCGNLSHYGIRSLVMNPAIHSVAIVGCCYNLLTEKLGPPTYKYTYARPSLQALNGRVVRESARHDPEGFPLSETLSTYKGEGVRMNITARMMACQAPQNWTQTESDDFFTRHLFRAVLQKIFLDRGVINKVYHRGMDDNEAASDENGDARPDESPFNTSTNPVIIGSLRKACYRSLKDYVRGAVAKLTTNREYSQYSDVIRDKMAGISDEDIAAYERDYLCRKKEVAAVWSLMAFSATVVESLIVTDRWLFLREHTDVVRDCWVETVFDYKESPRNMVVVGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXS1</accession>
    <name>H1UXS1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05094</name>
        <name evidence="10" type="ORF">CH63R_04432</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <strain evidence="12">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">IMI 349063</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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        <property type="protein sequence ID" value="CCF33247.1"/>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59722" checksum="751509A13DD95D6A" modified="2012-03-21" version="1">MDLPMSFEVAQYGGDDAVVVPVVHPIEDPVVHHKLELLHLPPETIRNIISFVPLSLASETSFDAGEQVVSRRTLCNLSLTCEALCDLSQERLYSTVSVDNAKRFGLLLRSVAERPALLLLMKQLYIGYFTTDEYSCETGLQAFDACSVDFSRSPLAMLEMVHRCGTYDAKSTIQHLVGFLLAAASRLERLVFAFKRSWDVNTVNQSTEVFFSDILPSVVNVVNLFKRLRELELRSDTRQRYDNANVSVSPFFVPSLLKASNLKTLRIPCDNGNWRFFDRIRPSQHFALENIALNGSSTSGSNLSRLLCRCPKLKSLVIVLNFPVSRWETFCIGTEQVRISDFLPEYCQKLHTLRLQLKRFGGFFVAEEGCFQRFVDMKELAVLRVDLPVLFKNANDMHHAHMQARLPPGLMELELYDVWTDDGRFQREYTLQGDSDLVLISHERVDASAEPLTVMLRRLAAVAPHHLPHLRSVRVKSVIYDHDSGQTASQLAAVFENVGIEFEVISSHDGEDCPLEFGGVLSVMNHLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZA3</accession>
    <name>H1UZA3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05518</name>
        <name evidence="3" type="ORF">CH63R_07425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000707">
        <property type="protein sequence ID" value="CCF33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157178.1">
        <property type="nucleotide sequence ID" value="XM_018302400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZA3"/>
    <dbReference type="STRING" id="759273.H1UZA3"/>
    <dbReference type="GeneID" id="28866507"/>
    <dbReference type="KEGG" id="chig:CH63R_07425"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07425"/>
    <dbReference type="HOGENOM" id="CLU_2096723_0_0_1"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="116" mass="12435" checksum="5BEE8B23CC31529A" modified="2012-03-21" version="1">MVKETGSANGTKHVGTYNVTPVHAEQSAAQSVLGSPGIEAPPSAKACVALVFITTDWVFLIFALCVLGPTHGANKLQFGNVSAARGQYRPRFCKRAALERYGKHVEYRGHGSHLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1V247</accession>
    <name>H1V247_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_06325</name>
        <name evidence="6" type="ORF">CH63R_04578</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001088">
        <property type="protein sequence ID" value="CCF34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160799.1">
        <property type="nucleotide sequence ID" value="XM_018299553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V247"/>
    <dbReference type="STRING" id="759273.H1V247"/>
    <dbReference type="GeneID" id="28863660"/>
    <dbReference type="KEGG" id="chig:CH63R_04578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04578"/>
    <dbReference type="eggNOG" id="ENOG502RQ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_880028_0_0_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="35338" checksum="93E9B306966EF5C6" modified="2012-03-21" version="1">MSAPSSFLGYVSDENRDDEAQSQTKSTPRRKPKYLQYPPDVPRLTRLGLCTYGVNTGPVADDADLTKLTVPMLKEQLAMREMPDNGKKKELMERLRGWRTYKPETVAIREAPENHAFGPISQKASASGEKRFWANPEEKGHISATKKAMQESMYIIKQQDNYDGSLGFTVDVRGSGSDAYQVKVGGKTSCTCSSINYRPKSNCKHIIFVLTHVLHAPAELLPQRTLFREELTKLLDRAPKVRFTAAEASTDTSMSDGVPKSKDGKCCPVCFKDIGKAQTVCCAKCGNHTHSSCFDVYAEEHSGWGVNCAVCQGDWSPAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3A7</accession>
    <name>H1V3A7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06646</name>
        <name evidence="3" type="ORF">CH63R_04574</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001243">
        <property type="protein sequence ID" value="CCF34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160795.1">
        <property type="nucleotide sequence ID" value="XM_018299549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3A7"/>
    <dbReference type="STRING" id="759273.H1V3A7"/>
    <dbReference type="GeneID" id="28863656"/>
    <dbReference type="KEGG" id="chig:CH63R_04574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04574"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="38791" checksum="5F583FD6B03696E3" modified="2012-03-21" version="1">MPHSITVKQIEGKPGAVYYPLQLNEVPKPSPGPKDVLVRLTAAALNHRDLFIRRHLYPGISFDHPMLADGYGIVVEVGKDASQDLLNKAVLITPSRGWASSPDGPEDIRKFSVIGATKIYPDGTAQDYLALPETEVELAPEHLTPVEGAALSLVGLTGWRALVTKSGNAEKGRNILVTGIGGGVALQVLQFAVAFGCNVYVTSGDEAKLEKAKKLGAAGGVNYKKPGWEKDLQAQLPKSRPYLDAVIDGAGGDIVGKAVKVLKPGGVISQYGMTVSPQMDWLMQAVLKHVELKGTTMGSREEFRDMVAFVREKKIRPVVSRVVTGLTNLEGIDGLFKDMDAGTQFGKLVIKFEEEPASPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3P5</accession>
    <name>H1V3P5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_06759</name>
        <name evidence="12" type="ORF">CH63R_06131</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
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            <authorList>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
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                <person name="Hainaut M."/>
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                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018299201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5N7"/>
    <dbReference type="STRING" id="759273.H1V5N7"/>
    <dbReference type="GeneID" id="28863308"/>
    <dbReference type="KEGG" id="chig:CH63R_04226"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04226"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:PeBoW complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="NLE"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="375"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="480" mass="50991" checksum="99D11A46132B2C83" modified="2012-03-21" version="1">MESSAAQVKVNFTTTHEDLQLDESKKQLIVPADIKRYGLSRILNSESMLNTSSPVPLDFLVNGTFLRTTIEEYLKENGLSLETTITLQYVRSLLPPVYEASFEHDDWVAAVDILSATSAAGRWSGDALAHGQDRILSASYDGLVRVWDGSGQCLATSPSTRAGGHAKLLTDAKFLSSSQIASVGLDQKVLVWKYTESADRFSGELKPTLELHGHKKMINSLAVHGPSKKLLTASADGRVGLWLASKKGSPDVDADDIPATHASSVKRAKLSNSSVTVPQKGALAMIHAHADASVTGAAFHPTDPTVAYSVSVDHTLRTLDLTTASVVSTLTTLHPLLCLTPMPRNSSLVAAGSAARHVALLDPRVSASATSVLTLRGHANMISALAPSPDNDYSLASASHDGTVKIWDLRSVRPATKDEGGGSASEAVYSIGREWLKGKKTPAGGEGAKVFALAWDQTWGIVSGGEDKKVQINRGRDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6C7</accession>
    <name>H1V6C7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP synthase complex subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_01373</name>
        <name evidence="2" type="ORF">CH63R_00605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001691">
        <property type="protein sequence ID" value="CCF35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163942.1">
        <property type="nucleotide sequence ID" value="XM_018295580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6C7"/>
    <dbReference type="STRING" id="759273.H1V6C7"/>
    <dbReference type="GeneID" id="28859687"/>
    <dbReference type="KEGG" id="chig:CH63R_00605"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00605"/>
    <dbReference type="eggNOG" id="ENOG502SDW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122989_0_1_1"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018301541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9K6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06566"/>
    <dbReference type="eggNOG" id="ENOG502T544">
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    <dbReference type="OrthoDB" id="4851285at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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        <property type="entry name" value="DUF427_sf"/>
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    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="164"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="275" mass="31159" checksum="3EAB6E5F4EC6FF9D" modified="2012-03-21" version="1">MSKPGQFRADLPELARHLLTNGPHKSQPTSRRVRVILNHTYIVDTTKAIHVWEHVAYPQYYVPTSELRNCSWEDKQDIPSPKDTSAVAAHVIRVTIPGKNGSESVATDRALRFSDDEELGGVLRGMVRLEFGSMDGWLEEETPIYVHPKDPFKRIEVLPSSRPVEVRVAGKTVAKTDFAVHLLETGLPTRYYLPLASVDQAALRKSELVTQCPYKGDAEYYHVVVDGEEHRDLIWYYRLPTHESAGIAGLLCFYNEKVDILLDGELLERPTTFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBP0</accession>
    <name>H1VBP0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_08925</name>
        <name evidence="13" type="ORF">CH63R_08739</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002560">
        <property type="protein sequence ID" value="CCF37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155736.1">
        <property type="nucleotide sequence ID" value="XM_018303713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBP0"/>
    <dbReference type="STRING" id="759273.H1VBP0"/>
    <dbReference type="GeneID" id="28867820"/>
    <dbReference type="KEGG" id="chig:CH63R_08739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08739"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR07218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="125" mass="13534" checksum="0FE3D7BED14A5CF6" modified="2012-03-21" version="1">MADQSAAWPLADDALQQEILDLVQQCQHYRQLKKGANEATKTLNRGVSELIILAADTNPLSIVLHLPLLSEDKNVPYVYVKSKTALGRACGVSRAVIAASITSNEGSELAGPIRALRDKIERLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCB8</accession>
    <name>H1VCB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01786</name>
        <name evidence="4" type="ORF">CH63R_05120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    </evidence>
    <sequence length="678" mass="74657" checksum="A6850E3927DB6AE4" modified="2012-03-21" version="1">MADVEEPKFNSLAERIAALNQQKNFKAPEVKPKRPPPPPPPTNRPVPRSQTLPVAQTNGLPTPQISPTIPPRPVKTTPAKPSPPPLPRRTTDSSQVDTSPPRDRIAPPPLPTRTSTQHISPALPPRRPSTQQLAVRRSSNASEISNLSSLSLNHTVSSATSIHSIDGPTRKLPPTLDQANLPPLPPTKREREAQAKDAAAQQTQPHKHALVSVKSSPAIRQIEPPHRPVLPPRLTSRSTSQQVHEPTLQEEAPAKPRRLPPPPTSYVKSQPHAIGYTGQEQQANDRPPLPGRRPGTDDDAPPPVPLSSRPSVSQIEAVSAKAVARANDCLICRDFSGPDGVAAQHPRQSLPRNDPVGYLAQVLCGPFASHTDKARAIFTWFHHNIAYDCAAFFGNNIRGRSGADTIFMGKAVCSGYADTYKEIALRAGLECITVTGHGKGYGYTPLEKGERPPPKKADGHAWNAVRIDGGEWKLLDACWGAGNVSDVTKDYTPDFKPHEFTRRNDIFGLSHYPSDDRHFFRPDGRVPSWEEYYIGPVHGDKPTVYSHAYEEGVWDHTISPKELQIPVYSGQVVRFQWSNKCEHWTSERHGKGKPPLLLLSIKGRDGRKEDMVPVETDGFWHWADVNAIDLGAPGQSVTVAMITTIDGQDARGVTAKEYFAKKGRCSMSWTYLMKWELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VE43</accession>
    <name>H1VE43_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_01922</name>
        <name evidence="13" type="ORF">CH63R_10443</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02003001">
        <property type="protein sequence ID" value="CCF38496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154841.1">
        <property type="nucleotide sequence ID" value="XM_018305417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VE43"/>
    <dbReference type="STRING" id="759273.H1VE43"/>
    <dbReference type="GeneID" id="28869524"/>
    <dbReference type="KEGG" id="chig:CH63R_10443"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10443"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_2_1"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="215"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF38496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="54283" checksum="DA76C0A60964BCC3" modified="2012-03-21" version="1">MSRTYNIAMVSDFFFPQPGGVESHIYQLSTKLIDRGHKVIIITHAYEGRSGVRNLTNGLRVYHVPFLVIFRSATFPTVFSFFPILRNILIREQIEIVHGHASLSSMCHEAILHARTMGLRTVFTDHSLFGFADAASILTNKILKFSLSDVDHVICVSHTCKENTVLRASLDPLMVSVIPNAVVAENFRPLDYPSSDAAGQPFGQNPPPAHHLGPNDVITIVVISRLFYNKGTDLLTAAIPRILENHPNTRFIIAGSGPKAIDLEQMIEQNVLQDRVEMLGPIRHEEVRDVMVRGHIYLHPSLTEAFGTVIVEAASCGLYVVCTQVGGIPEVLPSHMTVFAKPEEDDLVVATGKAIAALRANKVRTERFHEQVRKMYSWTNVAIRTERVYHGITGELSEAEFYGFDTANPSTFGNSRVRSFTLIDRLKRYYGCGIWAGKLFCLCVIVDYLLFLFLELWFPREQIDICPEWPRKIVDDAEDSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFC7</accession>
    <name>H1VFC7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_09901</name>
        <name evidence="9" type="ORF">CH63R_08330</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
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    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">IMI 349063</strain>
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    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
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    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="19">IMI 349063</strain>
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        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
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            <location evidence="3">Chromosome</location>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
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        <property type="component" value="Chromosome 8"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR05180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="137" mass="14817" checksum="2BA9A67A103A9182" modified="2012-03-21" version="1">MPPKAADKKPASKAPATASKAPEKKDAGKKTAASGDKKKRTKSRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVASEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VID3</accession>
    <name>H1VID3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Csi2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_10672</name>
        <name evidence="5" type="ORF">CH63R_04147</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003810">
        <property type="protein sequence ID" value="CCF39986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160368.1">
        <property type="nucleotide sequence ID" value="XM_018299122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VID3"/>
    <dbReference type="GeneID" id="28863229"/>
    <dbReference type="KEGG" id="chig:CH63R_04147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04147"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037244_1_0_1"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497690" evidence="3">
        <location>
            <begin position="30"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF39986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="368" mass="38355" checksum="779EA4C199CC3690" modified="2012-03-21" version="1">MAPSHNSLKRTLLLSTFAALSLFSATGLAQDNTNGGDAQTSARQSSQAASTNAASTNQQEPSTTAEPTRTTQPTAVITNTGAVATTEESISAPRITGGSQTDGEILTGLPSLTNAPLVTTYPPPTVPPTNNAPYMHRSTAPQGTVFIAVGAILGAFGLGILIWRGIVACLLHRSVARAANAQHAVNDKASFPAPPAQFYKYTDRESTPSLVPNGGRGVRRTQRGPIPSATPSQSNLFFSPTAAGGGNNNSTNNRDSRFLPSGFYAAATSSPGPAHSHSISLTNLRPDSRGQYGSRNTLRESTPPDSPSFGARRDFSTSSVNLSTTPGNGQRAPSAYLEDLLDENPHAFPPNTMRPGSRNANNSPGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIJ9</accession>
    <name>H1VIJ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10718</name>
        <name evidence="3" type="ORF">CH63R_00815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003843">
        <property type="protein sequence ID" value="CCF40052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H1VIJ9"/>
    <dbReference type="GeneID" id="28859897"/>
    <dbReference type="KEGG" id="chig:CH63R_00815"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00815"/>
    <dbReference type="eggNOG" id="ENOG502T48U">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="4794991at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15635.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="213" mass="23329" checksum="2184EDFF5375F9B3" modified="2012-03-21" version="1">MAVRIPRLDTKMPHPQDRKHNHMLFHVDPTDYQHDNYSPQRSPQYKLSNESASSLAQGHDPLADSEDDGSFAVISLSEEATASGALSETTGSDDTVVDQTATRRAAGTPAVLGSALTQDNIHLHDRVYPLGSLSTYQWVWGQPCLGGFDIKDTSSKESMKVHVSRSRVSQATENLDSEYGVVNHPSEAYVAFAGDWADVAADPAMMEELDRLE</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
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        <name evidence="13" type="ORF">CH63R_00550</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02004857">
        <property type="protein sequence ID" value="CCF41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163887.1">
        <property type="nucleotide sequence ID" value="XM_018295525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VN82"/>
    <dbReference type="STRING" id="759273.H1VN82"/>
    <dbReference type="GeneID" id="28859632"/>
    <dbReference type="KEGG" id="chig:CH63R_00550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00550"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_003182_0_2_1"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
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        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Jelly Rolls"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="cNMP-bd_dom_sf"/>
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        <property type="entry name" value="Membrane-Transporter-like"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="SLC26A/SulP_dom"/>
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    <dbReference type="Pfam" id="PF00027">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="cAMP-binding domain-like"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="361"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="422"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="456"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="528"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="588"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="782"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="118"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="25"/>
            <end position="34"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="130"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="146"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="176"/>
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            <begin position="258"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF41686.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR15370.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124138" checksum="805A26ED2C57E3B2" modified="2012-03-21" version="1">MASPNLGFSPWRRRAASLSSQRTGENNNPENPLLSPGRNSQMADPRILSSSVSSSHREPIRSFIHGNVRDHLGKHPVTGAYVTPVAHAANRLQTAPVDSAQYARSVREDTAELASYLLSDKKTGQSPAFLSRQRSQSSALARETAVSDDEDGDEDGDEIAHVTSSETIPEVSEPPSPDEDAEGVIEDGPSILTNLLKKSPPQSHRDPSPEPRPEPLALSDPEPKRTLSTDTPRCEPQRSTERVVDEPTERTPLIPRMSSDSFESYDTTGSTDGVDVEGQKQRPRKKWLRGLKDLTVNVEEHLVHGIQIATSPKAWDRRALWQNAVVAPASCLPAVVVGLLLNVLDALSYGMILFPLGKPIFAGLGSAGISIFYVSTIVSQLTFSTGSIFKGGVGSELIEVVPFFHNMAQTITDHIGEDQPDAVIATTIVSYAISSMMTGTVFYLMGRFNFGYMVGFIPRHILIGCIGGVGWFLVATGFEVSARMDGSLEYDMDTLHKLFRSDTIPLWVTPLLLAIVLFYSQTRGASKYFLPLYIISIPVVFYFFVFSLDALEPDSLRDNGWIFEGPPSDEPWWYFYTLYKFNLVEWDAVLECVPAMLALTFFGILHVPINVPALALQSGEDNADLDRELKLHGYSNFISGMAGSIQNYLVYANTVFFMRSGGDSRLAGYMLAALTFGVMIIGPKIIGFIPIMMVGTLIFDLGFELLLEAVWLPRKKLKLAEYLTVIVIVLVMGIYDFVIGIGVGIILAFVSLIIQTSRVSAVRASYTGEIVGSTVRRNPSQHHYLQEVRRQIYIVKLTGFLFFGTVVSVEEKIRALIDDSAFAERPIKYLILDLYHVTGLDYSAGEAFNTISRLLDNKGIVLVLSGKDAESEVGRNLRAMGLGNDSIEVTLLPDLNSALESCENELLKTLYASQEELRKGSRHAPTANLDVPTKPDQTSFDLVINSPRRNHLHEAARNALANTESSGTKRWQSFKEPLRLMLQIFQGLSDKNEDFWFRAVGYFVRKEYTAGTVLFTRGEPAKGFYLVEKGILRADYDLPQGSLTESIVAGTTCGELPFFSETDRTATVTVDRDCVAWRMDKEGWQKLQKDQPDVAQELLRVSLKLTSERMTSITSYILTMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNZ5</accession>
    <name>H1VNZ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_02719</name>
        <name evidence="2" type="ORF">CH63R_05141</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005046">
        <property type="protein sequence ID" value="CCF41949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161362.1">
        <property type="nucleotide sequence ID" value="XM_018300116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNZ5"/>
    <dbReference type="STRING" id="759273.H1VNZ5"/>
    <dbReference type="GeneID" id="28864223"/>
    <dbReference type="KEGG" id="chig:CH63R_05141"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05141"/>
    <dbReference type="HOGENOM" id="CLU_2941606_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF41949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6759" checksum="19446F60DA9D520F" modified="2012-03-21" version="1">MINDPREFLEHGRPADVPEPYLIFRPSRDTLEVLVQKVPNMTEQVTVAAIYDECGCSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRB3</accession>
    <name>H1VRB3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_02921</name>
        <name evidence="9" type="ORF">CH63R_07023</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005634">
        <property type="protein sequence ID" value="CCF42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156776.1">
        <property type="nucleotide sequence ID" value="XM_018301998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRB3"/>
    <dbReference type="STRING" id="759273.H1VRB3"/>
    <dbReference type="GeneID" id="28866105"/>
    <dbReference type="KEGG" id="chig:CH63R_07023"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07023"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="90"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="519" mass="56480" checksum="61D292269E636354" modified="2012-03-21" version="1">MNNNKHTQEPVDSSRRTSSDQRDEDIEEYADIIPARSKSHNREIPGDSVLSKLPSGVLNFQDDPVSRHQSHAEIPYEAYNRFSKHRKHVIVAVISWCGLLSPISSTAVLSALPEVASEYKTTGDIISLSNALYLVFMAISPCFWGPLSQVYGRKWTCAVTASLFLGCSIGTALSPNIAAFFVFRMLTAFAGTSFLVTGPAVIGDLYHPTGRATAMGWFLSGTLIGPTVGPVLGGIIVTYTSWRAIFWLQTALAGVGVGGALFLMPETLQELKSAELKGLPMSKKIGVLWGMTNPIRVIRLFRFPNLVLVAIASGSLVWNMYGMLTPIRYVLNPRFSLTSPAQSGLFYLAPGCGYLAGTLVGGRYADYTVRRWIAERHGRRISEDRLRSCIPFLGAALPCCMLIYGWTVQQRAGGVAVPVVFMFLGGVSQLFCFPSLNTYCLDVIQGRSAEVIAGNFMVRYLFGAAGSAVVLPAIKKIGVGWFSTISAAFLVIGSLSVLAVALWGRSWRTRIDEKTTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRB8</accession>
    <name>H1VRB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12669</name>
        <name evidence="4" type="ORF">CH63R_06957</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005637">
        <property type="protein sequence ID" value="CCF42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156710.1">
        <property type="nucleotide sequence ID" value="XM_018301932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRB8"/>
    <dbReference type="STRING" id="759273.H1VRB8"/>
    <dbReference type="GeneID" id="28866039"/>
    <dbReference type="KEGG" id="chig:CH63R_06957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06957"/>
    <dbReference type="eggNOG" id="ENOG502QSKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_4_0_1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF42774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="380" mass="41679" checksum="D7F7EF354E8A7826" modified="2012-03-21" version="1">MGEDVGAATGDPGVGDSGGLGADDASVTRDCGDYKERRRHSRAAAAEAKVMNDDNYDDHYDGSDACSDFSSVSVDELPPIRAYGHTYHGSGLLLMPNDESERARLEIQHQLFKLCLEGALTATKLPTDRALNVLDIGSGTGNWAVEMGEQYPLANIMGVDISAALLPTTVPPNVVFEVEDANEDWAREKNSLDFVHMRNLVGGGIPDWRALFQQAYEHLKPGGQIEFSEVRTRYFDLVDSSGDEPTAPTEEEKDHGSMTACREFEIGFAQMAAIAGVDFDPIPKIPAILSSVGFERVGRWSDLVPIQAVGHDEKMVRKGAQFAQMLEYGLENYSLAVFVKGGWDEKETRNLLQRVHKESRDTANEAYGKVSFVTARKPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRY8</accession>
    <name>H1VRY8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II Aldolase and Adducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00455</name>
        <name evidence="3" type="ORF">CH63R_09697</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005790">
        <property type="protein sequence ID" value="CCF42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156694.1">
        <property type="nucleotide sequence ID" value="XM_018304671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRY8"/>
    <dbReference type="STRING" id="759273.H1VRY8"/>
    <dbReference type="GeneID" id="28868778"/>
    <dbReference type="KEGG" id="chig:CH63R_09697"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09697"/>
    <dbReference type="eggNOG" id="KOG3699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_1_2_1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="292" mass="31803" checksum="3E458757BE958783" modified="2012-03-21" version="1">MSTATITLAPSAADASLEVKPDMTEKSGVTALSTGGYEFPGIPDIPDLYKKRQWQLEHMAGAFRVFARKGFTEGTSGHISVRDPVDPNTFWINPLGKHFGMLKASDMVHIDENGQVIGGNRAAVNAAGFMIHSAIHKARPDIHAACHTHSPAGKAWSTFGRPLDIISQDTCNFWGIQAVYKTFGGVVLEADESEKIAATLGEKGRVIVLQNHGLLTTGGTVDEAAYLFTLMEKSCEVQIMVESTGLPKNFIGDNEAEFSAKVNADPETLYTEFQPDFEYEIWKSRGELHKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSQ7</accession>
    <name>H1VSQ7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_03029</name>
        <name evidence="13" type="ORF">CH63R_02830</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005968">
        <property type="protein sequence ID" value="CCF43265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162621.1">
        <property type="nucleotide sequence ID" value="XM_018297805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSQ7"/>
    <dbReference type="STRING" id="759273.H1VSQ7"/>
    <dbReference type="GeneID" id="28861912"/>
    <dbReference type="KEGG" id="chig:CH63R_02830"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02830"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_0_2_1"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF43265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="44629" checksum="73ABD339A0C8AC9E" modified="2012-03-21" version="1">MARSKQATPIRRQTSSEYFSKADALARTPSHGNGVATTATSSKSNGKVSVPAAPVEAKEAGVVQILIAVGGIYASFLTWAYLQEKLTTTPYGPASKPEVFKYPVFLNTIQSLFAATTGFLYLWFSSRGTTSLPPVFPSRGIVMPLALVAVTSSLASPFGYASLAHIDYITFLLAKSCKLVPVMLLHTTLFGKRYPLYKYLVVAGVTAGVAVFTLHSGSKKKKSVVNPDANMPWGMLLLSINLLFDGLTNSTQDYIFSTFKGYTGPQMMCANNLMSTAVTLGYLVLSPWLVHTGLGEYLGMDVAGNAGELKAALAFMARYPAVWWDVLGFAACGAVGQVFIFYTLSTFSSVLLVTVTVTRKMVTMALSVFAFGHSLTSMQWLGVSLVFGAIGAEAQIATKEKRAKEVAKRAAAAGKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQJ8</accession>
    <name>A0A1B7XQJ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Potassium transport protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_14612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150558.1">
        <property type="nucleotide sequence ID" value="XM_018309586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQJ8"/>
    <dbReference type="GeneID" id="28873693"/>
    <dbReference type="KEGG" id="chig:CH63R_14612"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14612"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="890" mass="97761" checksum="103176478D944319" modified="2016-11-02" version="1">MAWRPWEKFKADHPATADRMVEPWAAVRPYLPPVNFITVHYAYFILTGLIFAGIFHGLSHPANSVSFIDSLFLVISAFTTSGLNTVDISKLSTAQQAILALMMILGSPVFVSIFTIWLRARVFEKRFEDIVEAERNRRIKKTGTIVGMAGAMIGLPVMSSFKGSKRKQKKGRHERQAEADAFQLTGSTSREKGHDRSQSQTTNQESAPSGGMLESIEEGQKLGVSTSSTEPLSPKSNATTRRRPFSRDDGRQYISESFDFKTFIHENKKSVGRNGQFFDLTEEQREYLGGVEYRALKILFTIVCVYFVLWQLLGAITLGAWSYVHSQSITAVNSQNSWWAGIFLAISSFNNAGMTLLDAGVAAFDNDAFVLTIVTILSLAGNAAFPAFLRATVYFCSLVLKISVDDDEYTVWKEAFDFIVKYPRRLYMMMFPAKANFVFVTMFSTIAIMDWVLLLVLSIGNSAIEAYPVGKRVGLAVFQALSFAVVPVSSLYFDVLVLWVIVMYISAYPEIIVMRNSNVYEERSLGIYTTEPGKSEDLDSTANQSTDELLPTFGPLLSQPTFGHALGTERTAISASGLSQAKSGISTKPVKKLAAIGRRGTSFVGKQIQSRMNNFQGVGVTARPRLKRSAAINFDNPNAPPGSASTPEGHVSLVSQHLRGQLSHDIWAIAFALFLITLIETSHSIADPRSYSVFNFLFEIVSGYTNIGLSIGLPDHSFSFAGGWYTGSKLVMIMMMIRGRHRGLQVALDHAVKLPGWDNEAIAGLAAHILVSNAGIRRDPVTPCNVTSASLAELQDSMWSHQHSDWADTFSVNTAAHYFLSVAFMPLLAAAAQQDLGAGIKGRSEGRGAVFVTSSCASMHNATNVDMSSYATSKAATDHLVRLLAAKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQK3</accession>
    <name>A0A1B7XQK3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150563.1">
        <property type="nucleotide sequence ID" value="XM_018309591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQK3"/>
    <dbReference type="GeneID" id="28873698"/>
    <dbReference type="KEGG" id="chig:CH63R_14617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14617"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="113" mass="11950" checksum="FC93D7EE73308A66" modified="2016-11-02" version="1">MAPNGNAFVINPSAPEPPTQYAHARLAPAGSHRTIYISGIACVHLATGEWPGAKDNGDGTYELDVRVQTAAVLSNIDLIIRKATGGKGSVKNLIDSVVYVVDMKGDYQGINEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQR0</accession>
    <name>A0A1B7XQR0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150609.1">
        <property type="nucleotide sequence ID" value="XM_018309366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQR0"/>
    <dbReference type="GeneID" id="28873473"/>
    <dbReference type="KEGG" id="chig:CH63R_14392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14392"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600989" evidence="6">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="15557" checksum="3BC592305732FED2" modified="2016-11-02" version="1">MKEGTFLKKVFICFCVWLVPIATGAAAAGIGVMEPVSGNWCWITRDRPDLRFSLTYVWRLLIMFATIYIYAYIWRYLGRRLRPSAKTPDLLQRTDASVDTSAAVPPHNRIQFVQGLKRVAIGKLYQRRRSATTSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQT3</accession>
    <name>A0A1B7XQT3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150635.1">
        <property type="nucleotide sequence ID" value="XM_018309392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873499"/>
    <dbReference type="KEGG" id="chig:CH63R_14418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14418"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="436"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1562" mass="174267" checksum="D7548B4BA8914E28" modified="2016-11-02" version="1">MASGGLILLLAGVAAVGFLWLYRPARALSATIPSATYLEQNRGVQLRQVNLCADNDGETGKSIDIIAIHGLDTKSPETWEYRTPDGQKVNWLQDRHMLPAEVSNARIFTCNWPAELLETLDSDQDTLEELALLLLAGVQGRPPATNDRPILFIASCLGGIILTKALVTAKSEYLPVRNATRGIIFLATPFRGTSFEDVARWAEPGLRAWASIQGRQVTRLLDWVKSPAFDLIRLVGEFTQLCDNGNGKGYKVLTFYETQYTNLPAKIPFLSFLFSPSKKQLVDKSSAVLDCVPNPLRLNRTHVLMNKFRGPKDSDPDYKLVVDQIRHCLEEIRKGTPLERADAWIREKHYTQERLKIERLSGDLLSMDQCYINLALVETQRADRSKDTPEERALRPSPFSLSDRLKIKTPHENIQVKLEALFDLRKMPDGHIKPPRRILIRGRAGIGKTTLCKKIVYDFTHGTLWHDKFDRLLWIPLRNLKREARTNVPGYSMGHLFLHEYFSSPGATDLINALWIETHSEKTLFILDGLDEISSDLRDDMFQFLKELLNQPNIILTSRPHAVLPSGLKPLDLELETIGFYPQQVGEYIRACCKMTTANGIETFLQGRQLIRDLVRIPIQLDALCFTWDGLNAGPSLQTMTEFYMAIEERLWKKDVVKLGKLHEGQIPNLRPRDVIDLVDDELKFLEALAFTGMHTETIEFEPKHRDAVFNHFINKRILLLDATVAALSFLRTSDSLSQPKNQQYHFLHLTFQEYFAARYFVRHWNTNKPLKCLMFSQDSVKDILPVWFLQEHKYNSHYNIMWRFVVGLLDEGKKAARFFEEIEKEPVDLLGPTHQRLVMHCLSEAVSLPNEFRRNRENRLTEWVLFESDFTGSSTFARESELPERVLQDVLAASRNKRPILDGLAYSGKYLSETNVASLLEFLKDKDWNIPVSAAAALGKQSTLSDTTFTVLVGLLKDKDNGVRNYAASALGNQSTLSETTSTAITTITALLELLKDSDNGVRRSVAFVLGKQSTLSDTTFTALMELLKDKDNDVRGYAASALGNQSTLSETTIIVLVKLLNDDDSYIRRSAAEALGNHSTLSETTTTALIELLDDEDSYVQGSAASALGSQSTLSETTTTALVELFKHKNSYTRLSAASALGHQSTLSETITTALVELLDDKDKYVRRSAASALSNQSTLSETTTTALVGLFKHKDSYARSSAASALGMQLVLSETTITALLELFNDENSDVRRSAVEALGTRLTLSEKTATALNELLDDEDSDVRGSAAFALGNQLMSETTMIALAELLDDEDSYVRRSAAEALGNHSTLSETTTTALIELLDDEDSDVRGYAASALGNQSTLLETTTTALVELLDDEDIEVRRSATEALGNHSMLSETTTTALVGLLRHKDSYARSSAASALGMQLMLSETTITALLELFNNENSDAKSSAIEALGTQSNLMCRVLEALGLLIRSESQACFQASVFHHSRHIEFLYGSLLRQSFEKPFSLYSVDNQCTINEPSGLRTATLENGELLQDAVSNGRHGLRNISSYKLWGPFEEDEPQSSAASTLENQSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR77</accession>
    <name>A0A1B7XR77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150791.1">
        <property type="nucleotide sequence ID" value="XM_018308473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR77"/>
    <dbReference type="GeneID" id="28872580"/>
    <dbReference type="KEGG" id="chig:CH63R_13499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13499"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="407" mass="44161" checksum="7116D18E9CBBED00" modified="2016-11-02" version="1">MSANDTTVRRPFRECTEVSQLCPVDMTVLAYYPNFGANIFFAVAFGLVVLASATIGTWKRTWTFMLFVTGGSILETVGYAGRVLLHENPWNSSAFQIQICTIILGPTFICAGIYLTLKHVSANLHPALSRIRPRLYPLIFLPADLTCLIIQAIGGGLAAAAGQTNKKLLDGGNQAIIAGIVLQVVVLMLFGATGADYWIRVRKWAHAGDHGAGDIALYRAKKFRSFIYAVAVAYACVMIRCVYRVAEMAGGWGNHIMQDEVSFMVLDGSLVLVCVTLLTVFHPGLYFPAMSVTRKARAGEKSESTTTTTSTPENVKAESGHQSVTMCMVDAIHHKCGICHARLGKPRRRDLEQCFAALAAETPHRGTLRDTGLGPALSDPALQPSGLEFGVLKTAPAYTLTEPQHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSM9</accession>
    <name>A0A1B7XSM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151306.1">
        <property type="nucleotide sequence ID" value="XM_018308988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSM9"/>
    <dbReference type="GeneID" id="28873095"/>
    <dbReference type="KEGG" id="chig:CH63R_14014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14014"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="39225" checksum="6CD52FCEB3D1DD50" modified="2016-11-02" version="1">MDLPQPSLEELSRDRSPIVVGVVSMCLIISTAILALRLWTRYYIVKKIGVDDYAAAFSLVGEKMAGNLGAVSINPANCLTRLYVVIRYGLGRHQQTVTSEEYVKFRKCFWSCVFFHSLGHLSFKMSFLLQYHRVLCTPRMQGLYAAAMVLVASSGIGVVVTCFVFCVPLDGFWDQRVPARCLSQQVIFYVFGAGTIVTDIVIFLLPLPALSKLQIPRSQRFYLLGIFSLGFFIVGISVVRLQFLKIQPDFTWWNVDPGLWSIGELSAAMVCLCLPPLKILVNRARTTRTCPSRNASSRNFGALPSNAPLSPSSKITNLSTAKSSCVKPSSCGNVVVVETETLQDAMYRPTPALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSN0</accession>
    <name>A0A1B7XSN0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151283.1">
        <property type="nucleotide sequence ID" value="XM_018308965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSN0"/>
    <dbReference type="GeneID" id="28873072"/>
    <dbReference type="KEGG" id="chig:CH63R_13991"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13991"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="162" mass="17152" checksum="51D67193D1138F4F" modified="2016-11-02" version="1">MLNTCARMPLTCSLPPSSYSSTEPGIHRREHHAHEHALAFTVASRIRPSEPIISGAPADPNALAVLGSIWWIAKAGRSVTWQKDAEDADLGPLSVGNAGPAPMVPVFAAAVAVGDQHDEAVARPSSVLDSSFSHRTTMAIVTLAARLAAVFRPDLVSRLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSP2</accession>
    <name>A0A1B7XSP2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_14005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151297.1">
        <property type="nucleotide sequence ID" value="XM_018308979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSP2"/>
    <dbReference type="GeneID" id="28873086"/>
    <dbReference type="KEGG" id="chig:CH63R_14005"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14005"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601028" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="639" mass="70597" checksum="EF1EA2EEFB880A13" modified="2016-11-02" version="1">MLPVPSLSTLATLALGASAVVARTVQPRQPNIVFILTDDQDEQLGSIDYMPYVQKHFVKEGTYYRKHFCTIAICCPSRVSLLTGQAAHNTNVTYVTPPHGEAVPNGAIGGYPKFVSQGYNDKYLPVWLQDAGYNTYYTGKLFNSHDVDNWNNPFPKGWTGSDYRFMECCPHADVHEPVLLDPNTYLYLNATFQRNQSPPQSFPGEYSNDLVSDRALGFLDDALKYNGSKPFFLGVAPIGPHNNGLGGETSPGATPPIPAKRHENLFSNVTVPRTYNFNPDKLCPASLACLPGPGRIDPSSSLQVSNTAPQQQQPSMANWGLIIPQLNATEVAYGDNYYRRRLQTLQSVDEMVDAIIDRLDRAGVLDNTYVIFTSDNGFHIGQHRLKPGKTCAIEEDINVPFLIRGPGVPKGKTVDFVTTHTDIAPTIFSIANITLRDDFDGSPIPFSEEGIANAQNDPKHDHVNVEFWGTQRGYDAFGGVSANNTYKAMRVLGDGYSLFYSVWCSNEREFYDMKKDPGQMTNLAGSASGSGRLLDRPLSAVQDRLDTLLLVLKSCKAETCRLPWKRVHPEGGVENLRDALDAKYDAFYARQPKISFSDCKDFYDIAAEGAQDTLVYYDPRLAATGKLHGSEPTVVSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT12</accession>
    <name>A0A1B7XT12_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151427.1">
        <property type="nucleotide sequence ID" value="XM_018309109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT12"/>
    <dbReference type="GeneID" id="28873216"/>
    <dbReference type="KEGG" id="chig:CH63R_14135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14135"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="162" mass="18093" checksum="8B2A51C8BF8C1661" modified="2016-11-02" version="1">MSSKLFFDPMTLFRVAPLVTASFSVCFSWDQQFFLQNFLHPTTRSKIDGILPAYFDTFFRAGLPRVLVLFTTSTALGIANAVTGKPNTSRFYVAGAVLSAAHYLFVPWVMYPIRAIVHNESHGRSSEDLEKWLGVHTTRTLLVDVPAWACFFLAILGAVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUI9</accession>
    <name>A0A1B7XUI9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151926.1">
        <property type="nucleotide sequence ID" value="XM_018307509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUI9"/>
    <dbReference type="GeneID" id="28871616"/>
    <dbReference type="KEGG" id="chig:CH63R_12535"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12535"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601099" evidence="7">
        <location>
            <begin position="22"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="198"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="689" mass="73245" checksum="E2F17B93EA5CC15F" modified="2016-11-02" version="1">MLSGDLLRWLAVLILSNRVFSVPHQDKWQDLTIHKRNHLLARQDPPPDTMAPTPYIILADRDATREQIQNLKNILSTEAVPGSLEEVPSKRTGLVVFFKAAITSAQADAIAKVPGFGSATPDSKLEEDQPPSPAAPPSSSTPSQPSATGPPGSPQTTLPNPADIGLQSDAADDLKIISQPRGSSLKDIPAFGYASEAGKGVTIYAIDTGANIQHPEWTGMTGDKSFIYAPGAVQEETDFASHGSCVASKSAGPAYGTAKDANMVMVKLPDDLSLSAVFAALVEVSNDVYEKGIEGKAVIVMALGHTIPDLQMSTETAYRLLIIAIMAEDIVIVTASGNEATDEFDDLSDYPALFGDTTDIIVVGGVTNDGSRAFFSQGTGDQLTTSAPAFISCASGGSSGSKRAYGTSFGEPLSLSLPFHHSPFPLSVETHTQEEASLADCNAPAAPTVAGVVAVWLSQAEHHARLQVPGEVAAKAKAMVKSFSYPRVTGGPPVIWNGIDPRRRACRGMGNTANRRRQDGDATDCEEETTPTSAAAAAAPTGSSSTTSRPPPPPPPFRPSWSENPQGFRRVFERDGVASDNYDATSNSASERVTGNIEQWCLAKCTGESPPPPRPPLGIDLLLLETPRLTRDFGTNPDRCASVFLYRVLQFRRGAYFNPYYVCNRYNSAWSTDFVKPSSSSIDSGVAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUK0</accession>
    <name>A0A1B7XUK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151932.1">
        <property type="nucleotide sequence ID" value="XM_018307515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUK0"/>
    <dbReference type="GeneID" id="28871622"/>
    <dbReference type="KEGG" id="chig:CH63R_12541"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12541"/>
    <dbReference type="OrthoDB" id="4788795at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601085" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="152" mass="16558" checksum="D64D1ACF8F42D5B9" modified="2016-11-02" version="1">MRPIALVSILLLAAFAPEAAPAAVPAPKDLHLHAKVAGAPRPGWPYFQHPVCRLYAYGFFGRHHVVAASGVRDIPQTCSQLWANLREFDGCRLLTKAHCGGTDGYLQWRFQGWVSCNLGMVSSAWFDATGQALGILDCAGKQPDVQPEDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVR7</accession>
    <name>A0A1B7XVR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152374.1">
        <property type="nucleotide sequence ID" value="XM_018307957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVR7"/>
    <dbReference type="GeneID" id="28872064"/>
    <dbReference type="KEGG" id="chig:CH63R_12983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12983"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="190"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="510"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="799" mass="86027" checksum="3DF741EFF8A537C2" modified="2016-11-02" version="1">MATGVARSAVLLPHRVGSCPTTSNSLLATLPGLRNASTRSVSLQHSLLSQIRSVSSVPNRSSPLSRPVGPRCFAQRHPVPFAGKPQLPASIAILRYFSAGFPRHQQDSKPITDAQTAREENKDAKQAEPTMQDGEQLDDFQKTERAAKAAEVNLSAKLSKEGKSQGGKAGFSEIWRLIKIARPELRWLGIAMVFLVISSSVTMSIPFSVGRILDMATKDPAEDVRLFGLTMPQFFTALGVILTVGAVANFGRVILLRIVGERVVARLRSSLYRRTYVQDAEFFDANRVGDLISRLSSDTVIVGKSITQNISDGLRALFSGGAGFCVMVWLSPKLTGLLLIMLPPVAVGAFFYGRSIRNVSKGIQKNLGTLTKIAEERLGNVKTSQAFVGEVQEVGRYNNQVKKIFALGKKESTIAATFFASTGWAGNMTILAMLVVGGNFVREGAMSLGDLTSFMMYTAFAGSSLFGLSSFYSELMKGVGAASRLFELQDRKPGISQTVGLKVKSAQGPIKFSNVSFAYPTRPAVKIFNDLNFEIPWGSNVCVVGPSGGGKSTVAGLLLRFYNPTSGSITINGVDISRMNVKSLRRRIGMVAQEPVLFSGSIAENISYGKPNATRAEIIAAARQANCNFISDLPAGLDTQVGARGSQLSGGQKQRIAIARALIKDPDILILDEATSALDAESETLVNAALASLLKGKNTTISIAHRLSTIKRSDLIIVLSNNGGVAEIGKYTELAADNNSAFSKLMEWQMSGGELPDSRPGDRGHITESEEIESDLGREDPEGDVESQLQEEIKEHTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWB7</accession>
    <name>A0A1B7XWB7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152562.1">
        <property type="nucleotide sequence ID" value="XM_018308145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWB7"/>
    <dbReference type="GeneID" id="28872252"/>
    <dbReference type="KEGG" id="chig:CH63R_13171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13171"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="175" mass="19903" checksum="1B726A8CA138A735" modified="2016-11-02" version="1">MIETGRQEASSFGSTGWRDENPESRHPEKKRRNYMMNSLGKSRVGKGERPHSPAYQARNDIWNQTSSEVRFLMLRRKHASLCWPAAFSQAGVVVKPGRRMWCRGLKSYEVLCCRDVPGPRPSRYCLFHRSNLERVGGRSNLSGSCNAPWGGLASRHLEILLSRPVQDGSRIALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX28</accession>
    <name>A0A1B7XX28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152845.1">
        <property type="nucleotide sequence ID" value="XM_018306004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX28"/>
    <dbReference type="GeneID" id="28870111"/>
    <dbReference type="KEGG" id="chig:CH63R_11030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11030"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="278" mass="30199" checksum="8C2BB13136170F6F" modified="2016-11-02" version="1">MFATLRTEDRHGEVPRRRKVDRTSALDNVEAAKTTVAAQTIITTSAEGFRSEQLLPAAHTQSARGSQIGESLVQAPGFIDSSQSSGSQSCELLPGTSPDFQDLDLPDYMESNTNDFDMDELLDVHGALSEQDAEALEMGSAFATCTSPKDKATTRESSLATSNSSSEKVVGILEDVASVWESTTLACGSDGNAAQIEVYGHAHRWVPISLGQYHIDTVQERCEIFGFLILAQAKNLGSLLDRLRLHAEERRLESQQSSLQPIALRVQELQEALSGMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY86</accession>
    <name>A0A1B7XY86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch-like protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153222.1">
        <property type="nucleotide sequence ID" value="XM_018306381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY86"/>
    <dbReference type="GeneID" id="28870488"/>
    <dbReference type="KEGG" id="chig:CH63R_11407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11407"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="45882" checksum="C4E547E5F1B59408" modified="2016-11-02" version="1">MRNIESGPQGSHGTAASKDAAAWFFLAPKPKELVKLKCGDKSFSFRKSILVKDSEYFRACLTNPAFVEARTSTIVFDDIEPELFGFYLHMVYLRAAGKRVDTTPILFKDDSLTAPGKGLAAVVKLYQIADRFLNTSLLSELGNEIVHFAEHGSCSVELPGPRALQKPFANPDQPRRKEHRTMNPETPVGRIWWTKVLRNAYDVLDKDRADQNFMKTRLVEILCDKVPTEHAFDIVPVLSESKEFLSAVSFCLAKKVSSLKAQVKVQSREVERLRYQNQTSGSQLATLRATTNAEISRLYNKTSHMSVMPSYSYPDDSSDDDDDYDGGNVGQGDPDGSGHDFSYDHDDDGELNHDDVGGQEDGDGIVGAYDETDVASEYGYDCDGNGHDDDGGGYCSDGGCSDGDYSDDGYSDGGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYB9</accession>
    <name>A0A1B7XYB9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153274.1">
        <property type="nucleotide sequence ID" value="XM_018306433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYB9"/>
    <dbReference type="GeneID" id="28870540"/>
    <dbReference type="KEGG" id="chig:CH63R_11459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11459"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="44099" checksum="166C1BEBB83DF462" modified="2016-11-02" version="1">MHRGPVHHPPSPASHAAWSLQGPSRPPLPSHPHVSRWVLKKKVHPSTHGCSASLSTYPISPSSRRKKCWRLPERRRGSTYNRGSRTDIENRGEWILSGLNDSVGRSPHQSTMASDQERQNSLIITACLFTGISTLVVVARTFVRTVVIRKPGLDDYAMLVAMAFTLAYLAEIFMGKANHIGFPRDSLSMENMTNLLKITLAIECQPLHKMWDLTQTVEGVCINTTAFFYFTSGFNIVTDIWILVLPVKTLSGILRPRREKIALSIIFGVGLFATITSVIRLHTIYTYTLAEDVFRESILVNIWSMLEINIGIICASVPALKPLFTPKALREATNRNRRTGYQYHSQERSAFNSNGSNSRDGAFDLNRVGEQANSKTMFQSTSRKSRSEDSILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYI1</accession>
    <name>A0A1B7XYI1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase GroES-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153346.1">
        <property type="nucleotide sequence ID" value="XM_018306505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYI1"/>
    <dbReference type="GeneID" id="28870612"/>
    <dbReference type="KEGG" id="chig:CH63R_11531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11531"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="54681" checksum="96EC588B28D02A0B" modified="2016-11-02" version="1">MADIPETQTVLILYAAKQPYETAEGYQVPEIEDEHEVLVKTEHIGLNPIDWKAPDFNFAIPSLPYISGRELVGRVVRRRPSSHSRLRDGDRVLVISTDYRDLRKAAYQQYVVTADFNAARIPPSVSPRAAATLGVAFVAAVLSLGVCMGVDFSTVPGAPGPDLLTLLRGVDPESLPRDIRDECLAGIRDHERAVAGDWVVVWGGSSTSANIAVQLARLAGLRVVTVVDKLRHGLRLSNHTVLRPDLLVDSHDPSRAVDIIRANVGKNLRFALDTSGRESAGWLLRALRPEQDAAGAPPSPPDTPRNTSPTLKHLIGLTGLPKEQAPDSVAYHTVPIKVFHEVPAVGEALVTWLERLLESGLISPPELLGVEQGFDGINRGLDRMRRGEIRGGRMVVSLDPAGAEAEVTRDASVPPALVDSPMAGGGVEEPQQSESSVASSPEFTSQKLADTGSRRGSATLWQGGPAVSSVPRSVPDGGQLSSEGEAAQGSQRRGSLWQPKPEGIAVETSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZM4</accession>
    <name>A0A1B7XZM4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_11903</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153718.1">
        <property type="nucleotide sequence ID" value="XM_018306877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28870984"/>
    <dbReference type="KEGG" id="chig:CH63R_11903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11903"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1413"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1530"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1620"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1666"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1705"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1736"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1802"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1862"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="363"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1935"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR05200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1954" mass="223326" checksum="CFF3D92B6FD75DB4" modified="2016-11-02" version="1">MSGHPAGSAGGGGHQDYDDGYGQQGRGHGNGTQQTDSYYQDDQQYYDQNGYDAHGHPQQGAEGYYDESLDTNMTSLTTFLFRGYYNADPNNAYHQDGGYYDNNEQYQDEYYNNNGNGNGYYDQDYNQGYAGGPRRQGSEEDSETFSDFTMRSDMARATDMDYYGRGDERYNSYDQGGARGFRPPSSQISYGGNRSSGASTPNYGMDYANMMSAASREPYPAWTSDAQIPLSKEEIEDIFLDLCAKFGFQRDSMRNMYDHFMILLDSRASRMTPNQALLSLHADYIGGDNANYRKWYFAAHLDLDDAVGFANMKGKGLRRKAKNKKKKGEAENDAEALEDLEGDNSLEAAEYRWKTRMNRMSQHDRVRQLALYLLCWGEANQVRFMPECLCFIFKCADDFLNSPACQNMVEPVEEFTFLNNVITPLYQFCRDQGYEISDGVYVRRERDHDKVIGYDDCNQLFWYPEGIEKIVLEDKSKLVDVPPAERYLKFKDINWKKCFFKTYKETRSWFHLLVNFNRIWIIHLTMFWFYTSANAPSIILGNKYEQEANNQPTKAQLFSIMGFGGTIAALIQVLATLAEWAYVPRKWAGAQHLTKRLLFLLLILVINVAPFVYVFVLPNPNEKIAEILAIVEFVIALLTFIFYSVMPLGGLFGSYLTKNSRKYVASQTFTASYPRLKGNDMAMSYGLWLLVFGAKFGESYVYLTLSFRDPIRYLSIMKLDCMGDALFGNILCKNQHYVLLALMTFTDLIFFFLDTYLWYVLVNALFSIARSFYIGSSILTPWRNVFSRLPKRIYSKILATGDMEIKYKPKVLISQVWNAIVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDHSFKTEFFPTNSEAERRLSFFAQSLSTPIPEPVPVDNMPTFTVLIPHYSEKILLSLREIIREDEPYSRVTLLEYLKQLHPHEWDCFVKDTKILADETSQFNGDNEKNEKDTAKSKIDDLPFYCIGFKSSAPEYTLRTRIWASLRFQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSDKLERELERMARRKFKLCVSMQRYAKFKKEEMENAEFLLRAYPDLQIAYLDEEPPLAEGEEPRLYSALIDGHSEIMENGMRKPKFRIQLSGNPILGDGKSDNQNHSLIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMKTENVSPYTPGVKNKMINPVAILGAREYIFSENIGILGDVAAGKEQTFGTLFARTLSQIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNALLRGGRIKHCEYYQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHLNNMFIMLSVQMFMICLLSLGALRHETKSCNYNRDVPITDPLYPTGCQNTDALMDWVYRCILSIIFVLLLAFVPLVVQEVTERGVWRAAKRLAKQFGSLSPFFEVFVCQIYANSVQQDLSFGGARYIGTGRGFATARIPFGVLYSRFAGPSIYFGSRLLMMLLFATVTIWQGLLVYFWISLLALVISPFLYNPHQFAWSDFFIDYRDFLRWLSRGNSRSHASSWIAFCRLSRTRITGYKRKALGDPSAKMSSDVPRAAITNMFLGEILTPLLLVAVTVIPYLFINAQTGVEGANNSNVSGDPPKRTNSLIRVGLVALAPIAINAGVLLMMFFMACFMGPLLSMCCKKFGSVLAAIAHGLAVVMLLVFFEVMFLLESFEFARTLLGMIAVVAIQRFVFKLIISLTLTREIKTDAANIAFWTGKWYSMGWHSVSQPAREFLCKITELSMFAADFVLGHFLLFIMLPVILIPKVDMLHSMMLFWLRPGRQIRPPIYSMKQSKLRRKRVFRYAILYFTMFILFMALMIGPAVVGDLIPMDIFKQLDTTSIALIQPTKYNNDNTQQSSKTGTGRDDYSGAYLTMTPSSSSSATGNSERVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0Y5</accession>
    <name>A0A1B7Y0Y5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_09794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154192.1">
        <property type="nucleotide sequence ID" value="XM_018304768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0Y5"/>
    <dbReference type="GeneID" id="28868875"/>
    <dbReference type="KEGG" id="chig:CH63R_09794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09794"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="557" mass="60663" checksum="DF186C8BEBA1242C" modified="2016-11-02" version="1">MAATTTHDAHDEKDLSVHEAKQPAVVITKTVMGDEAFQQAMLKEPPSWFGNPIIIPAIMVAFCCSTTNGYDGSLFGTLLSNDDFKNFFGVENKGIAAGIVTAMYQIGSVVSIPFVGPAIDTWGRRVGMFLGSLIIIIGVIIQITCIQTGSVNQFMAGRFFLGFGVQIAAAAGPIYVVEIAHPAHRGVCGGLYNVMWPVGALVASSAARGALDIGGSTSWAIPVGLQAMFPGIILLGSLLLPESPRWLYTNNKREEARRILSRLHARGNNDSEWVKLQINEYEEFLELEGSDKKWWDYRALFKNRASFYRLTCNCLVSCFGQWAGNGIVSYFLSAFLDTAGIRGGPTQMNVQMGMNAIQIVFAAAGASIVDGVGRRPMLIVVNIVCGLCWIGVIVPASIANIVDMDDKDAAAAINPNVSRAMLAWVYIFQICYSAGWTPMQALYPVEVLSYEIRAKGMAFSGLFTNFALLSNQFGVPVALEDIQWRTYIVFCVWCFVQAGILYFLVPETKNRTLEELDIIFSSPNPVKASTAKKHYEVDAGANIVHVEGSTGHDAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0Z8</accession>
    <name>A0A1B7Y0Z8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EC35 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_09807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154205.1">
        <property type="nucleotide sequence ID" value="XM_018304781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0Z8"/>
    <dbReference type="GeneID" id="28868888"/>
    <dbReference type="KEGG" id="chig:CH63R_09807"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09807"/>
    <dbReference type="OrthoDB" id="4927890at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601257" evidence="5">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="163" mass="18683" checksum="6A1E125015E18CA6" modified="2016-11-02" version="1">MHTSSFILFFGLLASVVSAVTLYRGDSRGPKQIKEAGGFKSRADHDHAEGTLFEHVTKQLKHPMKNRYIPTTVDINEAKKQGGSKYLYHLNSDEIEEQIWDVAAEYEKAGKTYPYASEQEFAVEYHIPWEAITKVERNVDGQWKTIKLSKRGVELFEENVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y242</accession>
    <name>A0A1B7Y242_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA recognition domain-containing protein containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154585.1">
        <property type="nucleotide sequence ID" value="XM_018305161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y242"/>
    <dbReference type="GeneID" id="28869268"/>
    <dbReference type="KEGG" id="chig:CH63R_10187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10187"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="147" mass="15437" checksum="AE194B2E8EF4BF90" modified="2016-11-02" version="1">MSGKLDQSLDEILSTQRRSAGGPGRRSQRRSTGGRPAAAAPVGGVQKTSKPARAAANKPNAAKPAPGTGDSKVIVSNLPKDVNEQQIKLSDFVRHVISRPSSFPAGVVARSNLWVAIATCQPEFAKTPQDSFHDTAILKYGAESFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4X0</accession>
    <name>A0A1B7Y4X0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155552.1">
        <property type="nucleotide sequence ID" value="XM_018303529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4X0"/>
    <dbReference type="GeneID" id="28867636"/>
    <dbReference type="KEGG" id="chig:CH63R_08555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08555"/>
    <dbReference type="OrthoDB" id="3542181at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601334" evidence="2">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="236" mass="24586" checksum="B8D1F7810F23B551" modified="2016-11-02" version="1">MHSLSFLLVLFASSTVALPATPAAPTSPLSTPTNTPDRPGSSQHLQPEPFLPTAIPVSTDVPETDPTPTPIYTTLTPKTPSNSSSPAINSTAPCFSRRPPLRLGPARLHRKPSRDSLLSTTGTRQTTPTSFAAPAVAVAVAAAAVETPTDSGPRDYASLIPPAPGVTPRPEPNLAELGFYQTTYYSCVTRKASVHCGWHRPILVAPANNAAGSPSASRRVGMWVLVAGLVGALVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y521</accession>
    <name>A0A1B7Y521_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155613.1">
        <property type="nucleotide sequence ID" value="XM_018303590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y521"/>
    <dbReference type="GeneID" id="28867697"/>
    <dbReference type="KEGG" id="chig:CH63R_08616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08616"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="81" mass="8604" checksum="754034CC9E99F1E7" modified="2016-11-02" version="1">MVSFANVLKPQASDESDEGRASTEVEKDSGGIGDGEGSSGRRNSKPSLTFLEAVLGLNGVGFRGTEVPIRFMSKKLVRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5T5</accession>
    <name>A0A1B7Y5T5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_08879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155876.1">
        <property type="nucleotide sequence ID" value="XM_018303853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5T5"/>
    <dbReference type="GeneID" id="28867960"/>
    <dbReference type="KEGG" id="chig:CH63R_08879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08879"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="665"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="916" mass="103512" checksum="1E0BFC6A42D5407A" modified="2016-11-02" version="1">MSYNRLDDDYYNDRMDPRYHRTPSPGQPLQHGYQLEDNPFNNAAYQQAPPQHIDDPYGRPSPHQQLDVPTGPARYGTPSDQLQLNAAHSVSNLSGYETPVNHGEYGVNPEAHHDAYYNQPYEPSPHDPSMPYDQPTGYSEYDDNRPMLPHQDSTATDGYQDNPTPQPAGGIKRWKTVKQVLLYRGNLVLDCPVPPRLLNQIPHGERDEFTHMRYSAATCDPDFFYDDNFTLRQKLFSKPRHTELFIVVTMYNEDEILFARTMIGVLKNVEYMCSRKESKSWGKDAWKKIVVCVVSDGRAKINPRTRALLAGMGVYQEGIAKQQVNNKDVTAHIYEYTSQVGMSIKNDVVTLVPKQQPVQMLFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLIDAGTKPGGNSIYHLWKAFDLEPMCAGACGEIKAMLGTGGKHLLNPLVATQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGQGPLEKYFAGEKLEGAGAGIFTSNMYLAEDRILCFELVTKRNCHWILQYVKSATGETDVPDTVTELVLQRRRWLNGSFFAGIYAIAHFYEFFRSDHSMLRKLMFFIEFVFNTINLIFAWFAIGNFFLVFKILTTSLGEDNLLGRTGEILGVVFTWVYGIALITCFVLSMGNRPAGSGPYYITMVYFWAFIMVYLLFAAVFIAVKAIIADVNDANGFNVTDLFKNPVFYTLIISVMSTYGIWLIASLLMFDPWHMVTSFAQYMLLTPTYTNILNVYAFCNTHDISWGTKGDDKAETLPTVSTKDGSGKTDLPDEADLNAQYERELKVFSTKFVKEVKQPTESQLAEAQMDYYRGVRSVTVLAWMISNFGLAAVVLSAAGLERINPSAGTTDDTDGRANIYMSVVLWSVAGLSAFKFIGAMWFLVVRMFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6W7</accession>
    <name>A0A1B7Y6W7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156243.1">
        <property type="nucleotide sequence ID" value="XM_018304220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6W7"/>
    <dbReference type="GeneID" id="28868327"/>
    <dbReference type="KEGG" id="chig:CH63R_09246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09246"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601387" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="128" mass="13638" checksum="A3784B7D86C07AE4" modified="2016-11-02" version="1">MQLLSFLAAGLVAATGVHSFGIGISGVALGLVLVLAQAAPFIPETASSNLKRQDGRCRSRNPADCQKEETRERSGGAVVAAEAAAGPEDEDLEERQGGRCQSADPRDCQKDKREELDAARLEDEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7W0</accession>
    <name>A0A1B7Y7W0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156630.1">
        <property type="nucleotide sequence ID" value="XM_018304607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7W0"/>
    <dbReference type="GeneID" id="28868714"/>
    <dbReference type="KEGG" id="chig:CH63R_09633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09633"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="143" mass="16266" checksum="5B8E32B904653C4A" modified="2016-11-02" version="1">MEWTRLTEKGAFLELYPSDFGDRTSTCTRPIRRKSQRRDMASDADTDTEAGAEVAIRIDFKHIVEKLCEAVHLAIAHENTQPVFRKRLEPGKRQAQTTSKPKPNSKIRIRAPANIHSELVGAEPLRRSSRLASRTRFENATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y857</accession>
    <name>A0A1B7Y857_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein with serine-rich domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_06981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156734.1">
        <property type="nucleotide sequence ID" value="XM_018301956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y857"/>
    <dbReference type="GeneID" id="28866063"/>
    <dbReference type="KEGG" id="chig:CH63R_06981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06981"/>
    <dbReference type="OrthoDB" id="252020at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="338" mass="37061" checksum="8908B9DCCB7098B2" modified="2016-11-02" version="1">MASASRSPSRDRYRSRTRSLTPMSNRSRSPARRRSYDSRSPSRSRSPTPRRSGRHRTESRSRSRSRSDSRGRSASPSVRTTKIVVERLTKNINVDHLEEIFGQYGRIKDLHLPINGTRKSPSSFRLAPMFGLQIHQADVPYLVGTNRGTAYILYETEADAEEAIAHMHEAQLDGTVINVSIVLPRRKVSPAPPQARRGGGFDPRGPPPGGRGGRGGGGRGAGSFGHNGPRRGASPPPGRFGPRSDTYRPGSPSRSPTRSPGAAPPSRGGGSRYRSRSRSYSRSPSPPPRRGGGGRGNDRNRRRRSPSRDSYDSYDSRRSRSPSQSRDRGGRGGGRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8F4</accession>
    <name>A0A1B7Y8F4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_07118</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156871.1">
        <property type="nucleotide sequence ID" value="XM_018302093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28866200"/>
    <dbReference type="KEGG" id="chig:CH63R_07118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07118"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1206"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1284"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="106"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="803"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="757"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="775"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1433" mass="159341" checksum="2F9B4B0056CBB75E" modified="2016-11-02" version="1">MTFTAPDTKEEVTLSSSSIRAGVMESDGTLASGSNYERSIELSAVPDDNNNNNNTTWSLKHKVEAVRERDQRSGFPARELGVTWQNLTVQAVSSDASIHENVLTQFNIPKLVKESRHKPPLKTILDNTHGCVKPGEMLLVLGRPGSGCTTLLNILANHRRGYSSVTGDVHYGSMTADEAQQYRGQIVMNTEEELFFPTLTVGQTMDFATRLKIPFRLPEGVASDEELRVQNRDFLLESMGIQHTFDTRVGNEYVRGVSGGERKRVSIIECMATRGSVFCWDNSTRGLDASTALEYTKAVRAMTDVLGLASIVTLYQAGNGIYDLFDKVLVLDNGKEMYYGPMKEARPFMESLGFICSDGANVADFLTGVTVPTERAVRPGYEKTFPRNADTLRAEYQKSDIYPRMVAEYDFPTKEDTKERTRLFKEGVAGEKHKQLPANSPLTTSFATQVKACIARQYQIIWGDKATFIITQVSTLIQALIAGSLFYNAPNTSGGLFMKGGALFFALLFNSLLSMAEVTNSFTGRPVLIKHKSFAYYHPAAFCIAQIAADIPVILFQVTIFSVVLYFMVGLKTTAEAFFTFWIVVVATTMCMTAMFRSIGAGFKTFDDASKASGFLVSAAIMYNGYMIQKPQMHPWFVWIFWIDPLSYAFDALMSTEFHRQLIPCVGPNLVPNGPGYTDPAHQSCAGVAGAIQGETSLTGDQYLSALSYSKSHVWRNFGIVWAWWALFVALTIIATSRWRPSAESGSSLLIPRENAKTVRVPREDEEAQSSEETAVEKDKSDSEKRDGGDNDNQDLVRNTSIFTWKDLTYTVKTPSGDRVLLDKVSGWVRPGMLGALMGSSGAGKTTLLDVLAQRKTDGTIRGSIMVDGRPLPVSFQRSAGYCEQLDVHEPYATVREALEFSALLRQSRDTPRAEKLAYVDTIIDLLELHDLADTLIGRVGNGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAFNTVRFLRKLADVGQAVLVTIHQPSAQLFSQFDTLLLLAKGGKTVYFGDIGDNAGTIRDYFGRYGAPCPEEANPAEHMIDVVSGHLSKGKDWNEIWLSSPEHDAVVRELDHMIDDAASRPPGTSDDGHEFALPLWDQVKIVTQRANVSLYRNVDYINNKFALHIFSALFNGFSFWMIGDSVGDITLRLFTIFNFIFVAPGVLAQLQPLFIDRRDIFETREKKSKMYSWIAFVSGSVVSEVPYLVICAVLYFVCWYYTVGFPSDSARAGGTFFVMLMYEFVYTGIGQFIAAYAPNAVFASLVNPLVIGVLVSFCGVLVPYSQLQTFWKYWMYYLNPFNYLMGSMLVFDVWGTKVECKDQEFALFDPANGTTCGEYLAGYMQGMGASSNLINPDAVSECRVCQYRDGSDYLRTINLNEYYYGWRDAAIVVIFAFSSYALVYLLMKLRTKTSKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y916</accession>
    <name>A0A1B7Y916_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156943.1">
        <property type="nucleotide sequence ID" value="XM_018302165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y916"/>
    <dbReference type="GeneID" id="28866272"/>
    <dbReference type="KEGG" id="chig:CH63R_07190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07190"/>
    <dbReference type="OrthoDB" id="4851011at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="721" mass="75965" checksum="5B456A34CC8D44C3" modified="2016-11-02" version="1">MGAGQGPPTQPHYAHAPYPPQQQYYAHPSQQSEPQYQQSQYQHQHQQHPQYQQYQQPHPAYQQPPPQQQQYYYPPQQPQYASPHPAAAAAAAAATTPGAPQPSPPVVSPPPQQQQFFAELDASEPPPTTLSQKPNPTSASVSTPSTATAAAHAQLSSPSPAVFEMPAEAPPPSKAQDPSPKPHAAAPVSGTEQQAGQKPPAVPQANPWGFFLDDGNDLSECVAPSSALAPSSTPATPAEDALSVKPLRIVKTGPADEKPPADSRPQSGGTQDVASQETGAGGSPDAAKLAPAPLHIVRPQSPAGPASPVPAAPPITQLPYPVNGPSIPTPESHPGARITLPLHPRSAAGSPSNPASPTTFAPSPLTPIQTATAVAQQQQPQQQHYHAQPPQAYTQPLPVSPVVIQAGLPPTLPVGSYFPQQPTYARPEATQQPAQAGAAASSSAHHSPAPSISSTIHAGDPQTVQTAQAQHSPARLYASPPPSYTQAVTQAQPATTSSRPAPAQFHHQPPTPTQPLSPTATGVSPPMSPPPSKYPYSPSCVGADKLNLHHHQGPAIPQPQHPSYNPHVSPPVPQPLYVNGPQQYHPNAPPLPPRTSPPTPGGQYGHAAPSPSSYGPPPTRPNYQAQPLPPKPDSRLFSSATARKLLSKTTELVDQTITPYLQDHRYRPPYNAYQYQYQHPNNRPLPGSQGPPYYQQGYGPSQPTYAAPPVARENPDVSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9M2</accession>
    <name>A0A1B7Y9M2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157301.1">
        <property type="nucleotide sequence ID" value="XM_018302523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9M2"/>
    <dbReference type="GeneID" id="28866630"/>
    <dbReference type="KEGG" id="chig:CH63R_07548"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07548"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="181" mass="19416" checksum="8A6F6B9D28F2B699" modified="2016-11-02" version="1">MRQGVYPSLARRPPSRTSPTTVYDKCSTTASTLTWPGPACLPSRGPNAIDLMGQTATCPSSGQEMMNGVEAMVTDTHPALLHPSSPVGACLGACLHSRERAALPAQSGRQAVRTGPVRARSCLHPLVRIDFFPLLWANLGPLAPRFVPPFHTSPHLQGAHRLLTLQKADYTVHPPSTLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9U5</accession>
    <name>A0A1B7Y9U5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157233.1">
        <property type="nucleotide sequence ID" value="XM_018302455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9U5"/>
    <dbReference type="GeneID" id="28866562"/>
    <dbReference type="KEGG" id="chig:CH63R_07480"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07480"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="84" mass="9670" checksum="2E1E682819D7A14E" modified="2016-11-02" version="1">MADKLRNQQELERLQAKYVGTGHPDTTSWEWKTNIYRDTYSSIAGHPPMLSYMALAENEPTQLLRARLIRKMMQPAGPPPARED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA18</accession>
    <name>A0A1B7YA18_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157313.1">
        <property type="nucleotide sequence ID" value="XM_018302535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA18"/>
    <dbReference type="GeneID" id="28866642"/>
    <dbReference type="KEGG" id="chig:CH63R_07560"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07560"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="509"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="785" mass="88117" checksum="84F8B57812CAAA57" modified="2016-11-02" version="1">MCLSVRSSSDPVPKDEGREGRFWRRKAPNGEKPRTKKRALTMPLWSTSNKTSANTLKGMVGLTTILAPTRDGFHFKLAQPMPSINVTNVDGATDPSSSSANSDHKDTPATSTSDEILLSFAIQNRLKKIFDDLRSRRSSLSRDPFVTREQLLVFLEKTQGEDDVENILPEDKERYNFGEFLETWWTHYGWDAVRPLKSEDKDLARPITNYFISSSHNTYLEGNQLASKSSPEAYRAVLRRGCRCIEIDVWNGDTPITTQEGARPDHSRNLSGSSLPNVAASVKETVEDILIDRNGHGSGHSRNPSNASRSLNPRDSTTLLGPSESTESLGNTLRPQSAGKNRLPYPKDEPIVTHGWTLTTPCGFREVCRAVRESAFETNDLPIIVSLEVHADKEQQEVMVKIMKQEWEGMLIDKSWEGIDPRFRLPKLEELKRKILVKVKKAPNKIEVPVSTTALSRVYANDEDASGSDDERIKEVPKTPNTPRTDTPVKIHSGSEAPTSAKVAICQALSSLAIYTHSEHFKSFETAAAKKPSHIFSISESRILELHATKAREMFTHNKNFFMRAFPNGARVDSSNPDPSLFWRKGVQMVALNWQYLDEGMMLNEGMFADEQGWVLKPIGYRSCDKDTVTEVDAAPQGDLELAVTIIAGQHIWAASDSDSNSSRAKHLRPFVKCELHVEIGAVNGKAADEDDFKLKTGSRKTDHPEWENGARLKFPKISRVVEELSFLRFKVEDDPILGSDELLSWACIRLDRLRPGFRFIRLMDIKNRPIEGGKLLVKIDKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAG8</accession>
    <name>A0A1B7YAG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157396.1">
        <property type="nucleotide sequence ID" value="XM_018302618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAG8"/>
    <dbReference type="GeneID" id="28866725"/>
    <dbReference type="KEGG" id="chig:CH63R_07643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07643"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="16585" checksum="4B20B5B842867411" modified="2016-11-02" version="1">MFSTTSNLRFGGGASSAFSPTAISCLRYGNESGNSAGVASARHGNAAARRKAHIAGSKARATSAMSGRSARITTQRSHSAIADPQERHDSEARPPPSPPIQSGAAAHVELHHKPICVPSSPPSPPSVKAGASHVIPDTMWAFPLRHRGIEYKTDRAICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAP6</accession>
    <name>A0A1B7YAP6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase transmembrane component 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_07911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157663.1">
        <property type="nucleotide sequence ID" value="XM_018302885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAP6"/>
    <dbReference type="GeneID" id="28866992"/>
    <dbReference type="KEGG" id="chig:CH63R_07911"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07911"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="138"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="12">
        <location>
            <begin position="389"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR09146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="579" mass="64414" checksum="2CFC7E59DE84789E" modified="2016-11-02" version="1">MLVGWFTLDLHHAALSMPTATMMQALRPPTTKQHCNEKTLKIYAVFLCGLLVLAFVARWLREICNRTPSSAASRASRDPHLFKWFHLFRKLERQADWGWFGRRSFGLIILVGIYLAGNTVFSSTNLAMYQLNHWASRFGWMCAANMALCVFFGLKNTPLAYITPISHAQLNIFHRIAGYTAVLLVLLHAIFYTIHFGRQGRWANMVKQENLEGIGAGISMLALLMGVLRHRSYEIFYVSHIVGFVAAVVLTSLHRPNWAKKLPVLMLFIATLWVADRVLRAARITYNLVNNTATFYSLPGGGTRLLLKKPGIEVAPPGAHCFLWIPRIHLFQSHPFTIVSNGPSGLELVMKSRKGFTKTVGNFAARYPRCTAWASVDGPYTSCPNTESYDKLILIAGGSGAAFTVGLMNRILSQSERPIHQSIEFVWAVKRAEQLSWFSEHLRNLSKAGSGVSVRLYVTSEDSVASPSLATYSDVESGVQPEMERSLSSKTGFANYGSISEVCDTDALLGGTDWDAVTFTRMDIEMVIGKAMGTSKSCQRVFVAACGPESLMDAVKDSADDWRSKRGFRIDVHCEDFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAY1</accession>
    <name>A0A1B7YAY1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pepsinogen c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_07954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157706.1">
        <property type="nucleotide sequence ID" value="XM_018302928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAY1"/>
    <dbReference type="GeneID" id="28867035"/>
    <dbReference type="KEGG" id="chig:CH63R_07954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07954"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF68">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601482" evidence="4">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR09189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="385" mass="40992" checksum="A961119DF0AE4C2A" modified="2016-11-02" version="1">MASVTRFFSAAAVVSVAAAAVLDLPIIVQNGYKTVEIDIGTPAKTYRLLFDTGSSSSWAVDSECARSTCANVSGYDRVGYSINASTSGSYTGGYADIAYLGGDTAGPTVSETWAASGISWRQDFIAANETNWAAMAGDGFLGLGFSSIIDGGANTVVETLMAQGLLDEAKFGIYYGTEHNQTGGEPGDGVLTIGGSRAADFVDGELVTVPVTRVDGGYDVWRTTMLAINGTRTTAADGSVVETETSFDFDRVVFDTGAGSITLPTEKNLAAYESIGWNYTAILRGEHVPLCSEFNATWSFKFTFGDYRDPQTVEVTGDQLRRPGFAYRDDACWPPFQDGGAGLVLIGTPFLRNFYTVWDYGAAANETEIGRFDPKLSFGKLKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBE4</accession>
    <name>A0A1B7YBE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157801.1">
        <property type="nucleotide sequence ID" value="XM_018303023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBE4"/>
    <dbReference type="GeneID" id="28867130"/>
    <dbReference type="KEGG" id="chig:CH63R_08049"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08049"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="13753" checksum="4D405C625F733A3F" modified="2016-11-02" version="1">MASRALRTLNLGVAAATPSLIARTPAATRSFANAAARRYAYKDTQDRESLNPSGTEGTKSGRDSEVAHEKEAFDPSTTRPGAEKREADGGALDVSGANQAASKPQGDEPHSGGGGGEEVRKGGRSGGGGGAKDGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD19</accession>
    <name>A0A1B7YD19_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immunogenic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158508.1">
        <property type="nucleotide sequence ID" value="XM_018300658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD19"/>
    <dbReference type="GeneID" id="28864765"/>
    <dbReference type="KEGG" id="chig:CH63R_05683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05683"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="72"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="567" mass="59688" checksum="B3128D86C7C57733" modified="2016-11-02" version="1">MAEEQKPVEVPKETVPAVTTEQPAAETKPVETTEAPAAVTADATTETPATTTATETPAEAVAPVEEAKKEVVPVEEGTLEHKGANFPKNFIYSKEFFWFGNDAVEFKNLSSYLKSEKSTEAAHHNAAWASHTGKGLLFFGDKTAPQGVINLADAAEPAADGANKFHFTAKGHKHTFKAANAEDRDNWISQLKLKIAEAKELASTIAETEAYKTALESLKPAKKEEKAAEAPAAEAAAVAEAPAAEAVAVPAATEEAAVKETPKEEEPKKEESKRRSASRKRGSIFGNLLGKKDEKKEEKEETAPVAEAAKEETPAVPVTEAPVAEVAAPAETPVAPVTEAPVVATETAAEDKPAEAAKETPKEEKKEKPVPTKRNSIFGVFGKKEKKAAAAADAEAAPTLAKEGEVTPAAETAPVIPPVEATTPLAVDVANPSTVPVEIKETAPATNGESRPELKEKRKSSLPFGFGKRDKSPAKSPAQSDGEETEKAEKTSTFSKLRATIKGRGKTEKSAEKLEKTEEKPEEAPAADAVKPATETPAAETSKAAEEPENKPENVASSTPAPVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD24</accession>
    <name>A0A1B7YD24_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158351.1">
        <property type="nucleotide sequence ID" value="XM_018300501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD24"/>
    <dbReference type="GeneID" id="28864608"/>
    <dbReference type="KEGG" id="chig:CH63R_05526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05526"/>
    <dbReference type="OrthoDB" id="4835975at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="476" mass="55411" checksum="C57B4B2F24A00922" modified="2016-11-02" version="1">MARTRGRGRPQIFRLPSELHYQILMELDSVSDLRAWVSTSHIAFEHFLEYKATVLDLHINDYVLPEALTVVRLRRIHEESTKPAKARDLVNLTCKLLESMEPLAPISALLPGDSYTSVALLELIEDVSLIESGITQCQSHPTLSAGSAPCSQPGCRTGWVWTDSYSDERYSDKWYQRPILVFELYAQCLYRNYEVYEAGEEQELYDRLGKMIEARADPYLGCPKRNLSNFNQVVEFVCRRNDDYLQLALRQVVRIYKISGEHSLKPHITVKESAQNLREAVDDPIVCSRSTRLFWANEDKMREIQMLDKPAIDLMRRNKDSNVSVAHVGTWHAASGDVPVYRLACPEWENAVWNGYPREFLYKKDRDGFTAVASLLLLRERKGWTPVDDIYNLWRMAAGGIRPLARLMRMTPPERQQQILNHYVRPASEVRGRIKDDLKWRSWHDPFLRKHVIRLYSGIRFFLPELCQWLSRHFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE40</accession>
    <name>A0A1B7YE40_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158864.1">
        <property type="nucleotide sequence ID" value="XM_018301014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE40"/>
    <dbReference type="GeneID" id="28865121"/>
    <dbReference type="KEGG" id="chig:CH63R_06039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06039"/>
    <dbReference type="OrthoDB" id="4842237at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="106" mass="11100" checksum="34BFF40432B49282" modified="2016-11-02" version="1">MPSGQGYEYKSSGTNSQARLLRNRRATVPVTRRAGNHYCARDYGSSASNPNSYHYSNTDGSYYYSNPNGSTYYNDGAGGSTYTSSSGERSSSGSGSGSGSGSSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE58</accession>
    <name>A0A1B7YE58_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158829.1">
        <property type="nucleotide sequence ID" value="XM_018300979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE58"/>
    <dbReference type="GeneID" id="28865086"/>
    <dbReference type="KEGG" id="chig:CH63R_06004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06004"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="30359" checksum="59EB3B913DF888CB" modified="2016-11-02" version="1">MDAVRSALQPVTHNLPAPIRDLGVSIIGEHCYKSLLLDINVEDVDCIKLGLSKGVGLGIVGVSSIVKLPQIRKLTASQSGDGISVLSYLLETASYIVSLAYNYRNQFPFSTYGETALIMGQNVIITVLVLNYTRRAGLAAVFVTALAAAVAALFTGSLVDMQTLGYLQAGAGVLSVASKVPQILAIWQEGGTGQLSAFAVFNYLAGSLSRIFTTLQEVDDKLILYNFIAGFLLNAVLASQMAYYWNAPSKKAKGKQKVPIAAAPPVSTGSSTATSAPRKGPSTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEA4</accession>
    <name>A0A1B7YEA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158934.1">
        <property type="nucleotide sequence ID" value="XM_018301084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEA4"/>
    <dbReference type="GeneID" id="28865191"/>
    <dbReference type="KEGG" id="chig:CH63R_06109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06109"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="85" mass="9734" checksum="24CDC74705779A81" modified="2016-11-02" version="1">MSQSGNTFYGQILSIEGEDRQHERAIDEEGLTDNDDNSEDEMTFSSHLLTMTNIDKFVQRLDQVSKTQPIDSHECIASRIHLFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFM8</accession>
    <name>A0A1B7YFM8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-beta-1,6-galactanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159386.1">
        <property type="nucleotide sequence ID" value="XM_018301536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFM8"/>
    <dbReference type="GeneID" id="28865643"/>
    <dbReference type="KEGG" id="chig:CH63R_06561"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06561"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039743">
        <property type="entry name" value="6GAL/EXGAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42767:SF1">
        <property type="entry name" value="ENDO-BETA-1,6-GALACTANASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601605" evidence="1">
        <location>
            <begin position="22"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="53050" checksum="18E81BCD15509D0B" modified="2016-11-02" version="1">MHFNPLAAVALGLASLSVVAADTTTIIDAKSDHGTWEGWGTSLAWWARRFGTRDDLADIFFTTKTTSLGGASLPGLGFNIVRHNAGACSWNAVNGERMVVSPKMMLSRQIEGHWVDWASADPASSSWRWDVDTAQRAMLQKAKSRGANRFELFSNSPMWWMTKNHNPSGSADGSENIQPWNLAQHAVYMATVARHARDNWGIDFESVEPFNEPSANWWKADGTQEGCHIDVPTQATIINALRTELDGRGLGAVTIAASDESYYDQAAATLTGLANAGALRHVARVNVHGYQYANGRRDLVSSLAAASGLRVWNSEYGESDATGERLASNLLLDLRWLRPTAWVYWQVLDGGGWGVVDADNEAGTVGAANQKYFVLAQFARHIREGMRILDGGADNVVAAYDAARSRLVIVAVNWGDAQYLNFDLSRFAQASTNGAKVTRWRTQIGASGDRYIQANDTTMSGTKFWSFFEKKMVQTFEIENVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG87</accession>
    <name>A0A1B7YG87_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_06873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159698.1">
        <property type="nucleotide sequence ID" value="XM_018301848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG87"/>
    <dbReference type="GeneID" id="28865955"/>
    <dbReference type="KEGG" id="chig:CH63R_06873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06873"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="486" mass="51789" checksum="7291EA427AAB45AE" modified="2016-11-02" version="1">MEPSVVSWPLWLRIWILLNVSFYNLLGNAFAAGAPPLFSRIIQELNCTSEEASQLSTYVLLTLGLSNVFALPAASLIGKRYTILASLVLFFVFCLWSAEASTFADLRASRILGGLAGGLVEALGPSFVAESFPEQQLASAMVVYVGLLAAGSAIGPIVAGVVAEGLGDWRWYFRILSAMIFVTFFGSLIMLPETRVEVSREAEVELSTITEDSPKGQLPSPTCTEIETANGRSGALSRRTSLGQQWRLRSFSMAYVDMDWKLAASSLIHPIQLLVAPQVLITTFIFGLTIGWTVLVSILVSVVYSPPPFLWGARAIGLLSIGPLVGLLVGLPVGGALADYLFNRATRRNGGISDPASRLPAVAIGGLISPAGCLVIGYGLQSPDKWAQVSIGYGMVATGLTCSANILLTYAVDTMPPRASHIGVLVNLIKNSVGFGVSYAATSWMAQVGPVAQFGTMAGILWGVYLLVIPLYLFSDTIIRKTSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGC0</accession>
    <name>A0A1B7YGC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_06798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159623.1">
        <property type="nucleotide sequence ID" value="XM_018301773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGC0"/>
    <dbReference type="GeneID" id="28865880"/>
    <dbReference type="KEGG" id="chig:CH63R_06798"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06798"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="770" mass="84719" checksum="3EBB0EDE6049638E" modified="2016-11-02" version="1">MESAPISTITRTPTTTTSAKPFSPAQAADTPSSDPSQPPTSVNNNGSNNPVVRPETGDLSGSRVRSSPGAGTSPGTGRKIERSCHLCHRRKVRCDKKLPCASCIRGGFQCYYPPVGQPVRRVRKTTIADVANRISDLEKSLVAGAVDQHHAAFRTPSAPGSVSDFASNHHHQQQQQHQQQHHQNPPASAPRSGIAPPPESHGKVAGDEILVRKGTSTQYFDEVLISRVIEEEHDIQSVLSTPGSEPAPQAAPSPFNPMGILSTPDPKLHLADLLPPKSGAVELWRNYVDNIEVCNKVLHRPTAEILVYTAIDDPHNAPVEAMAIIFSVFFMSVITLEPATVQSLTGEDKTTNLHRFKTGLEQAFAKADFLEHPSVRLLEALAIYLAALRIHNPGRGLWTLNGLAIRAAQSIGLHRDGTKLGLTTFESEIRRRIWWHLLGRDGRAGEDYGIQNSTGFSLHAGVSYPSNLDDGDLYPEMRELPPPRPGWTQLTIVLINIQSGRTWHRLATMASSWAERPTPESVRAQIVRELHDYAEGFLRNCNPVIPQQRQTMLVARFIIRKLDLVTRQQWLHLEHPEARESFATEENLQEALGILEAGMNLASDELLRPYRWSMRAYPPYHMLLYVLWHLCVKPEGPSVDKAWRAVDEHSALIRQVSSGSGPAAKMTILDALRAKALAVRQRLAQQNEGDGEGAGDAVGDVEAAGNADKEAYPTPRAEDRPDADGQDPSLYGSAGAEGMDWSSMMQDFPDWGTLMNEFQVDGLDFPNYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGP0</accession>
    <name>A0A1B7YGP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin fusion degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159756.1">
        <property type="nucleotide sequence ID" value="XM_018301906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGP0"/>
    <dbReference type="GeneID" id="28866013"/>
    <dbReference type="KEGG" id="chig:CH63R_06931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06931"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="445" mass="48214" checksum="CC06EBE45CB28BC7" modified="2016-11-02" version="1">MLPDVQDAYTLYGNPATTLLSLLSNPLILAHTAPHLSAYDRLVLASTSRAFRELIKHTSGVFRHLDLAQVRGAQFDIDGIDRGGEVWRNAQLDGNLTEDDFYSGPLRGILSNIRRQNILQDVQTLILDGLSVTAELCHEIILDPAYNVRLLSIRGVKNLNERKLCASLQYACRPSRPEGMPRLKGLYVFGAKDAPLLPMTASGVSSRTVGTPSQGAQIGAGWNAKSQQALTSSLRSEGEDWYQKKGRIIARPLVEEWANALVDCYGIIAFDGLACTGPHHMNSPAYGKVRIPPTARHWAVATVALGGCAGCGAAPEGMTIHTGTPAIERPLLSPPPLLTSSVKAATAPHSGPEAPSSSFVARCIDCLRERYCAGCDKWWCEECYQAPGAVTELADSDVIVVDAEGGTWVQHQEHEILPKIKVRNGACFPDCIMGEVMDAQRVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGR3</accession>
    <name>A0A1B7YGR3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159712.1">
        <property type="nucleotide sequence ID" value="XM_018301862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGR3"/>
    <dbReference type="GeneID" id="28865969"/>
    <dbReference type="KEGG" id="chig:CH63R_06887"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06887"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="124"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="292"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="556"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="697" mass="76523" checksum="C9119A9A90699B67" modified="2016-11-02" version="1">MDPVAKGPVLLLSLSTCPSKTPLGPSLEVSPQLNISWGTTAKMKSKDQLIEPTQLGTPQGRSQTRKSRVFWASCLSTLCLFALFGAWHRADPQRQLLGTWGRQPADKQDRLTRSYTLQSGVRWMNPDGGRWRVMFVCNGQSPCPTLYAEEGDLVELTVRSDVYSQSTIHWSGIGHKETGGWNDGVAGVSQFPILPRGNFTSFIDTTGSWGLNWYAEHTTAASADGLYGMVYVAPSSSRPRPYRLITSDGIELRKIMEAERQVRHLAIKNHQHRDTGWKMLRMRAEGSEFYCYDSILVNGKGRVHCRQPGFEKLNGQDLDETGCIQPPGLPDESCTPSNADYEVIETEGRSYIMMNLINIGFEHSVVVSIDNHKMIVVANNGGFVNPEETDVVYVPSAGRVTVLVRLNAEPGDYAMRISSTSQMQNLQSYSILRYPASRRPVYGQPMEVPQPSSPDSICVLPDGSARDGCKTVNGQFIAPHPASPPPKAEKSGNEAAADYTFHLAAGSQESLTEPHVPEYFLNGKPWQLFRSSLTPLLFQVANKSSSGDSLGKPVIEGIPMGSVVDLIIENELNDTIPLYKHAEAAWLLGAQPHQGFPFQSVEDAVAAQGEVSRSLNLHDPSLVTVHDLPPLGWSVLRFKVTAKAATMIHAVKLRYFALGMSAPIMEGILADDPVKLPESAVNRPHVVFEPKNDGVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHF1</accession>
    <name>A0A1B7YHF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160024.1">
        <property type="nucleotide sequence ID" value="XM_018298778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHF1"/>
    <dbReference type="GeneID" id="28862885"/>
    <dbReference type="KEGG" id="chig:CH63R_03803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03803"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="205" mass="22129" checksum="BC80F33A1E31DC3C" modified="2016-11-02" version="1">MDGYTAEVGGMGPQDEPAARIAPFFIPPLVPSVSINESIYPHSSKNLVLRTTQKLPQFSQVGGGGGEGGGGGVPAHDREGETESPSVFTQRDSQGAAGVGTTGATRSECRWLIGVLTGDPTLSFRKETAKEALPDCPGLWEDIPPPRLMSPPKRAYCSWCFRLHWETETLGTWATRRKASKVCLPNALETENQVFDAQDEGEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHM0</accession>
    <name>A0A1B7YHM0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160012.1">
        <property type="nucleotide sequence ID" value="XM_018298766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHM0"/>
    <dbReference type="GeneID" id="28862873"/>
    <dbReference type="KEGG" id="chig:CH63R_03791"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03791"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF37">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="761" mass="86678" checksum="77044F44651B73C7" modified="2016-11-02" version="1">MERTTTPNEESGGRKHGVEFSFSLDAPDNTRASTSCRDSLIQSEELVHRIPSSAEAEDRPRLGQPSVLDNHFPSPSIPPPGTGERSVWGKIIQNHGDYPDSPQIASDSGYSDHISVEDRDRYPPTPGHPRPPITAKKIANWMRSSYITSAQDQHDFLPCEKLREIISPDVLRTLFRGTFDYNDSAIEVLISKVLGQQNTLGNQPQLSRHKIIAILVLMDKIALIEDFIRGDIKDDDLPLKIKRTKVKNFEVTVRLCKKWETDPSDGSKSVEHLESLECLDSWSFNDMEDFEARQTTICTPFFELPGDKLRFYNLRDRPTLPFLEYAQPQVQEGASRHFAVKELHSVTEAAYREEIELFEKIGVRGPAQDPRHLLQLQFSYLHGDHYFLVFPWADGNLREFWRKNHSFKPGIRDHVLWFFKQCKGLVGALHKIHHYTSMSNPKANIKARIDDLKQGKKLKDWGRHGDIKPENILWFQQYENMTDFLVISDFGLTRFNTTKSRSKVPQDAIAGYSGTYRPPELDLGTSISPKYDIWSLGCVFLEFVSWFILGDTKTRDDFTDQRLRSEENTNLKEDKFFVLGEASDSIRYREAKVKPSVVSWIAELHAQKRCTEPLHELLDFIEFGMLQPDPKDRSACGQITREITCLLDRCKREPEYATRGKAGTRNPARFQSSERTAQAVNYMHLRTLKHSDEIQAPAEEDLLYGISPASSKEPTDIFTSPTLVSNVSGTEGLPSRLYTTSPPYQGMNGGLFGSGSQFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIC0</accession>
    <name>A0A1B7YIC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrogen assimilation transcription factor nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_03920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160141.1">
        <property type="nucleotide sequence ID" value="XM_018298895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIC0"/>
    <dbReference type="GeneID" id="28863002"/>
    <dbReference type="KEGG" id="chig:CH63R_03920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03920"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="272"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="716" mass="78810" checksum="6790DD392955A4F4" modified="2016-11-02" version="1">MSSSAAPREGAKRQRVSIACLACRQRRMRCDGQQPVCGSPPSKKYVESLQTRIRHLEAQVVSLGSQPASTQSDPNAQEADQAESTGEDDEQSPLSDLTGLVGRLNVIDDGQLHYFGSQSSYNLVREPLCDTDPHEPSLRVRRQGLAAAAQLGKIVSVSDDLQEHLLELYWRWQNPWNYVIHKSAFLKSFRGEDDGKYCSPLLLCSIFAIAARYSDRIELRSVADEPSTAGDAFCEHAKILLLYESEAPSITTVQSACLLALRIMSDGKEALGWLYSGNATRMAHNLGLHLDGSKWTTAGLVSEEEAEARKVTWWGCYVVDKLFAIGLGRPSSTPKSTISCPKPSIDNVEEFTPWLPGSDSLGGEKSLGIHSHISSTACHLSEIMTIACEAMDDIYAANRKLAIPEMEDIVSKTDVELRTHYRELPSYLRLPASIKTPMLPHVCLFQYVGGRTSRRRTLICRNLSDSINLCSIQYHAHLILLHRPLVHKRKRRSVVGVDVALENVGDEGDEYANRHMATCRDSAAEIARLLRVYKQQYTLRRIPIAAVHLCFSATVIHLIDARPTNPNRQQAIRHLQTCIDALRDLRTAWWAWSERALRAVRLLAREWYRCEDVSQLQDRSGLRAETAAGAPADFDIPDGAVAGVAGVSFGSSRGQGNCSSSGDGGSGGGGMGGRGIVESDTLAFLFDVATPDQYTDGLVKEWLAESGYDVLNSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIM8</accession>
    <name>A0A1B7YIM8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_04192</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160413.1">
        <property type="nucleotide sequence ID" value="XM_018299167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28863274"/>
    <dbReference type="KEGG" id="chig:CH63R_04192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04192"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="995"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1483"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1553"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="921"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1484"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1554"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1626"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1678"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1774"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1819"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1876"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1911"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1945"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1970"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1992"/>
            <end position="2001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2009" mass="213221" checksum="C1DE63856CCB0E5A" modified="2016-11-02" version="1">MSSETANASWHPAFMPNDAGGDATSRANLDASQPPALAPTQVAQDAEPLMPTQQVNQLEEEPGQETSPWLAEAPEEDATDDWPVFDREVIDVPVESDAATEEVADMNATAEPGPASPSPLPQASEGAAPEPRTVAEGSKPAAPVLGHTSNNSFTRTVSHEFNWDDDHDAEWTLPRTDTDPFKFMPPSDRTNSFPPVPPVSGASTTAPVPGTEQPLPSNQAEDLINEIESAPEHFDTGAREEMNHDATGFDGGFGDDEPRDDEQHYVGRDATFTEEENLGSRYEEGVPLIPHAETNGGGSQPSQILAGFEEEATGDDDFFSQVQSSGNDDFPDFAGNQPLERKSTIQVMGDMDTTTLSKVDTLMEMLEEDEDEAEDVNENKDEKKNNDDENDAAAETQPTDASDGLEANPEFAQLEDTEAKPTDDLAAKWEEAFADDDGEDFLLDDTNDESKPVDPSAFFGSDDEGFLEDDDEPQPPHPLPAAPSQVQPASQHGRYTPAAVPQQAASSPYAPITQAVSSPYQPQAPATPFVPAAPYGAQRTQSAALHAVQQTRPEPPKAQSFAAQSKGGYTSPYDLPMEVVVPKKRASMQQLPRSSSTGPALAPPRSSSMKAHTPPPPPGPALSSTPPARSSQSVQPPPAGNQGAPTLRNKDSFFEELPVASKPRSASRQSYRVSSPSLAGPPEPLQPSTQAQLAPSPLSPPMLSPPGMSRSASGGIPNLVPGERVNPYAPQSAQQQVPGIPSNARYSPAPPSAPTTNGVSRPTSSSRYSPAPTGARPPVPAFHSATASPTVLPHLPRTSSPLAHFEVSREAPANNGDHAQPDRRSSYSLEPRRVPSLPTTREVEEEDESKSSQPSQSANGVPAESRYSPAPPAAARQTPPPSYAPPMSSTLSPPKRSTSGYLPQAALHDSPPDNRFAPPQRSYTQSPVSSHEARPSSQPVPRPASVQSPTSPRAARAFQSAQASVPRPRGSSQSLNLVAPTDGRENDPLQRWKGAPIISWGVGGTIITSFPKNVPRYSMGSTAPMIIRSPGEVHVKHVKDIQPLEERLAKFPGPLRGKSKKKETVAWLTAGIETLEKELPDVSFQTHLSHEHKRTIERVLLWKILRVFVEHDGVLEGNAAVDKAVRDVLAPGLGTDEAEGATTTGYGAGVSGVDALQESSSTQMKADAVDSSVMNQIRKHLLVGDREKAVWVAADKRLWGHAMLISNTVSQDLYKQVAQEFVRKEVNYTGHNNESVAALYKVLSGNHDDCVDELVPAHARAGFQLVNTTSSTGPTKDATEGLDKWRETLGLVLSNRSHEDVRALNALGSLLSSYGRAEAAHICFLFARKTTVFGGLDDAASNFVLVGADHKTQGEQFAKETEALLLSEVYEYGLSLAGGSTLSAGVPHLAAYKLQHAMTLAEYGLRDKALQYCEALATSINAQTKRSPYHHPILETAVENLRARLKQAPKEESSSWITKPSMNKVSDTVWSRFNKFVAGDENDGSAAGASAEGGVESGPFARLAGGTPTISRSPSVSNFEPIYGAGAPSFPVGSPPAAVPLPVTRAASRYAPAASQTPALSSSYEPGSGYTPGPASVGRSSNEYSRSAYEPRTSMDSQPGHTNGGYIPQTPAAPSQNYTPLGYGNGQDTTASAQIQPGASTMSPTLQSPTKSKYQGYEPYGASHTPAVAADESRSQEPTENNQQPNPASSGYQPPSYGYEPPSLTPNDETETHAGESGGAGGYEPPTYQPYGYEPPSYNPEPGNDDEATEHKPKPKSFMDDDDDDDIPALKALKSQDKSKSDKDKENEEMFKKAAEEDGKHQERTTEAAGSLTLDTAKRAAAAQQQQKKGWGFTSWFGGKKEASPDPQQGNKPVKANLGESSSFVYDPDLKRWVNKKGGADATPAKTATPPPPKGAPRSNAGTPPPPRTMTPPMGRASAPPGGPPGPALGKASSQESLSVPPGASRPSSLIRSVSSTSTGGPLAGPPSRPATSMSNASSIDDLISAAGPRKPGAKKAKKGGRYVDVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJP0</accession>
    <name>A0A1B7YJP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160816.1">
        <property type="nucleotide sequence ID" value="XM_018299570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJP0"/>
    <dbReference type="GeneID" id="28863677"/>
    <dbReference type="KEGG" id="chig:CH63R_04595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04595"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="104" mass="11609" checksum="8E6F7397681B6502" modified="2016-11-02" version="1">MYPKGTPCPCAKSLDVPKIREDAELTRVGATIDIFRYHTRSGAAGSESHSQRTNRFGLDPETWVTFSSEVSCSFLIWPWPLSISVSTHTHLSYCLDESSRSWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKI0</accession>
    <name>A0A1B7YKI0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160885.1">
        <property type="nucleotide sequence ID" value="XM_018299639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKI0"/>
    <dbReference type="GeneID" id="28863746"/>
    <dbReference type="KEGG" id="chig:CH63R_04664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04664"/>
    <dbReference type="OrthoDB" id="5287295at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="52315" checksum="1F64E3C9114457EA" modified="2016-11-02" version="1">MAIQLPREELGTAVGVLVYSFFCLACSLLMAWLVYAHREGLSWLSTAASVAQQTHTLVRWRDIKLEQFRHSSINVGNPELAIAGQSTGLDLVLFYIQFYSYNVEALVTLFWAFALTQSIFQLEPARSLRKRVNYISKAVAVLLPALLVGILRLEAVQKQTVPFLVLADGIMGFCLSGSGVLLVVILIKYVYTRRNLLSWNVRYGQRSNSTKSSDTLVFDSSNGRRRGSIYDRWLVVRFSIAFVALAIFQVVTIMFQVTSARQNTRDSLSDSPDLSTERLHLDLLLFIPGVSASLLTFVVFGTTKTFRDYIASKLIPRWLRDRSRMKTSSPPSRRNRLSQTVSKRTAAYPPRLSLTPYVTNDGGLYSPIYDGNDIQLGDLNVNGSSKVAEDDQWPLVSPNAGSSDLKKPANVLAFCLKAMSQAFAGGSGRNVASSLLIRAAHVARRHSEGYATELRDILTGIVVHGPTGNYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKU8</accession>
    <name>A0A1B7YKU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161196.1">
        <property type="nucleotide sequence ID" value="XM_018299950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKU8"/>
    <dbReference type="GeneID" id="28864057"/>
    <dbReference type="KEGG" id="chig:CH63R_04975"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04975"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="799" mass="88083" checksum="772E85F6D4D4265F" modified="2016-11-02" version="1">MSLQYTAEFLVHLRESPLCIKPPALPPAEEWMGPLPDNSRTQGSSNNNNSQTKTPADRRSNDNPLLDQTNRRPALDRHVSRNSANPEDIILGPPRTAFASATLRNGKPFDSEKGIKDADSPSRFNFRNRNGDTPEGDRFRDSRNANFRRRGDGDQDQEGWSTVKPRKSFGHEGAERFQGRMGAGGGDRLPNERRPRDRDDREGHRDRTLRNFEHHDKDKDHDHEEAESRPRNGLSRGKSEPWFKNDSNSNNNISNNSNVASTPEKPPMTARERIDRAKSWRDRNRDAEPVEEKTTSRNYERRWDRGDHRQEREPEWFDEPAGEKSGGHTEEDFKKFMESMKASRNASAGDKAPVAVAEAAIKAEQPAVASAPAVEVGPDQFFLKFASTAGLDAGSPIEPNKETPAKPKTGGGKSSRFTSFFNAPQDDPSRRMQTEPSTPLAGLSIGAPDGSAPAPDSEKQAFQALLMKLQRSNVQSSTPPASHPFQEPPPLAREPASSSSVASPEPFQQYGGERREEHRPRMPQASMSMSDILAPRPTMPGQQPAVRQDQLLQELVGQRHQASSQGSGRMEPNQGRNMSNTEFLMNLMRNQPEPPRTEQLLMRMPQPQRAAQIPHAPERDPDFPQGIPQGIPQGMPQGGRGSQRQMRGQGPPGFMDEAFHHPEPEARMQPTQILQRPPPPPGLDQMNPNWIQGGGPLPPQQRSIIPPPGLAGGPGRNHPMGAMFPPNFPPGAFPPPEVMAGPPPRNMPPPPGFFGGPPPGFIPPPGMPGFPGPAGPEGHGFHFDGRMPPPGAAQAFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLC8</accession>
    <name>A0A1B7YLC8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161225.1">
        <property type="nucleotide sequence ID" value="XM_018299979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLC8"/>
    <dbReference type="GeneID" id="28864086"/>
    <dbReference type="KEGG" id="chig:CH63R_05004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05004"/>
    <dbReference type="OrthoDB" id="4840236at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="945" mass="104139" checksum="68444297D388BBFD" modified="2016-11-02" version="1">MNPLETEHEPDGTRLQNARQDDAENKQPGQRVARGFRRTYKACNPCRRKKTRCVVEIRDSPSCLRCDREGRECVFPPDRAASSQKNAAADALAQGRGGPASEGTSLAGQPGTPQPRSRDGYQHRRPQGSQRHALPRNPSPTVPPPFEQWDPMATENDNSFNTRCFGQAGGVSPGLEPVDLTNSMIRTIVSNGNDALKLLFRAAAEQEASGSGAAAPRVPSHASTSTLPSEPGNPASAPPPCLFCSFGTPSDLSRWAGSPPRKASGHFRLTAKEPLLCCVILLISTRYHHLPQPGGVARGVLVHNRLWEHCQHLIMRIITGQEKGSTARTRTRGSVEALLLLVEWHPRAVYFPPVPDGWDSSLLHSAFELGRTDDYGTREHISDESSGPAWQRDVVTPARTSDRMAWMLLGNAQTLALELGIYDTASRADAGVAHARQPGLHARSARVREVLYILMEQHSFRLGCPSMVPDTLARSVTGYPSANDGGGGGDDDEDSRVARAWIGLTMLVRSIHDMLFPTAGAVRHLLRTGRYASITRHFQQQLVEWRRKHLDSTAISPNAIEELHIEYHHAQAFLNSLGVQAIVERVMGSASASPTIRATLNSTVQGVEYDFIKKVVDGSVQVLRATQRLFVAGLLRYCPVRIYLRVIAASIFLLKALSLGTHAADLRSSLGCLHECIACLKASSLDDGDLAARYAALLEVFLAKFEQGMVPTSAPRISSMLLGQGELSVDDSGEGLGGADEGWDDVPEDWLALPLSHSLAPFQLWGEAPETMEPEVSFWDAMWNLPQEVINYLSGNTGFRDNVASHLFNLYDSLRSRRGKEDERAENGKSAVSLRDLLITRLKQPPQSQNCKKSRTPKTKHHPQCEPIPDPQRRGDFNPMDEQDKAYDRDMFFIQCTCHSFFRYTENILAQIGRSLLNAVICLTGRFTRNTTYFLDNPVSEEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLK8</accession>
    <name>A0A1B7YLK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Male sterility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161450.1">
        <property type="nucleotide sequence ID" value="XM_018300204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLK8"/>
    <dbReference type="GeneID" id="28864311"/>
    <dbReference type="KEGG" id="chig:CH63R_05229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05229"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="568"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119609" checksum="CB1FAA5B397F3FBA" modified="2016-11-02" version="1">MATTTVRVTEPRSLTVCGQRTLPAIVDERAIYEPEKTCFSTPYTSEPRDGWRKVSYKVFANAINYVAHVILENCGRPAPDTFPTIAYIGPNDARYAIMMVAAIKAGYKALFVSPRNPIEAQLNLFKMSDCRVVARPQSHRSVAEFWLQHWDMKQLEMEPLHDILSKPEFPNVPYTKTAAEAEWDPFLVLHTSGSTGLPKPIVVKHGSVALSDALHLMPDWNGAEPVSRVMERLAEKHFSPMPMFHAGGVYGFMSTAILSGKEVIYPPPERPLTADLAIEVIQATGATSASLPPSLLEEMCHRPDQIAIMKRLNFVGFGGGPLNKEAGDILWRNGIQLMNIIGATETLPFSLYYQKNSELWQYFIYNEELSGLEFRKATSEDNVYEMVITRKSTQLPTQGVFYTFPDKEEYRTSDLYQPHPTLPHHWKFHGRADNIINLSNGEKLNPVQMEEIISGNPAVKAAIIVGAQRFQPALIIEPFVQPKTAEETDDLIDRIMPQVAEANATIATHGRIVRHLITVSKPDKPFVMADKGALKRMATVRLYAEEIEELYANPREIPLSKVPTLDLSSRAALSKSIENLLREHLGVPHLDSDTDFFAAGMDSLQIIAAARFITASLRATGDRCGGVVIEARDIYSHASPIQLAGHILEAVAHGTSQGNGEDEAQSHRLMDQLYRTMTQDLIRAKSGRPEPAKEQQTVILTGSTGNMGCYLLDELIRNPRVKKVVCFNRSADGGAGKQAKAMEERGLRQPAESGKVEFLHTNLAQPNMGLPEAVYSRLLREADRVVHNAWAVNFNMPLEAFRPHIQGVRKLADFAAAADKRVVVVFVSTIGSTSNWDPSRGPVPETSLREYGLSGLGYGQSKLISSMVLEDAAKVGDFPLAIIRVGQIAGPLADDGAWSRQEWLPSIVASSLVLKALPRHLSGMNAVAWVPVETMSRMILDIGGLTEESRDYHEGYFHGSNPSVTLFDRLAPSIQRYYGKDRLPELISFKDWVDRLEASRTSAGALGADRNPGLKLVDFYRGAASSGEDLPRTRTHETRRTVSCSPSLRSVRPITPELMVHWCKQWNFEGAPQRVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNV3</accession>
    <name>A0A1B7YNV3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_02463</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162254.1">
        <property type="nucleotide sequence ID" value="XM_018297438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861545"/>
    <dbReference type="KEGG" id="chig:CH63R_02463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02463"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1375"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="18">
        <location>
            <begin position="674"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="696"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="732"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="768"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="804"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="876"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="912"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="15">
        <location>
            <begin position="948"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="297"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="423"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1183"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="312"/>
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        </location>
    </feature>
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            <begin position="333"/>
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    </feature>
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            <begin position="1043"/>
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            <begin position="1119"/>
            <end position="1128"/>
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    </feature>
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            <begin position="1183"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1201"/>
            <end position="1210"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1440" mass="156886" checksum="2F80D9C6A38FE493" modified="2016-11-02" version="1">MSGASVAQDSCREFRVAQIFKVPTPTAFYQLHPRYLTHLAYPPTSAPLHLCTTPPVPSIPCPGQVDKNQDPRRRSSRFSSPLQTSLSTPPSSLQPPLPSQSVVVPVDASSLQFASQAPAPAPAPSTSATCTLNPNSKGGDDGRQTTGAPTRAAIAIAHLETLDPPLPLHPRPSTLDRTRATVSAAKQRPPANMTTTPRHGPWLESLTRRSELRLDLANRSKKLASRLVTSHLPPIPSLFSHMAATLLTCHVLQARPTGRYGSFPMANGQNEKQAPAVPPTFAASNLYSQNIWTSTYGGAKRDTRGPEDSFPGQPSGSSALRENSEAETWGQRPWNQDSQTRTASGSASPNRTRDSLHSTTSFFDNNAVGQGRSLINGRPKSYLEDDKENTAFAPSYNSPFDATYARQEKRGSKDNAYLSLGVVGAPSRDSSIPPSRQSDDSQHHSPPAFRDTFGYGHTPSNSITSSRPVIPGHSSSFPTQTTNNRAFMANGRQMDDADLASQFKKSLTLDEAQSLAASAQNFQFNPVSQPWRGDVAATGDVYADAMAQYLPHNKRSSVVGASGGQYRVVASPKTFPPQSSDPWAQRQSPRDLRMVPDGDRRTPVPAFMQAQAPAFYPGPYYSPNFAGQYPPQMFDPYGRPSLPLPGYGLHMAPYSIPGVMPVRPGKDQDPGKGVRSLLLEEFRSSSKSNKRYELKDIYGHVVEFSGDQHGSRFIQQKLETANSDEKDQVFREIEPNAIQLMKDVFGNYVIQKFFEHGNQVQKKVLASQMKGKVVDLSMQMYACRVVQKALEHVLVEQQAELVKELEPEILKVVKDQNGNHVVQKIIELVPRQYIDFVMDSFRGQVSQLAAHMYACRVIQRMLEYGTEQDKETILAELHSSTQVLITDQYGNYVVQHIIEHGKSEDRSRIIQLVIAQLVTLSKHKFASNVVEKCIQYGTAEERKGIREQIISHAADGTSSLQLMMKDQYGNYVIQKLLNQLEGAEREAFVEEMRPQFNTLRKTSTSRQLAAIDRLIYATQTPPSKSGGSQADSTAPTPVLTMEPNSPQSSSPPSTSASAVGEVAEDDNHKISARGGVSLKVEAGDRRGAATGVRRVRPDAGGATVRLRAAARKGHRARGDDDEDDDDDGDKSRAGGGGCVQGGYRRRAGPAGRPERGDEEDYGIFPPAAAVAIAIANVVADGGSGRGGRGQGGEAGGAGPGEEERAARGDPAHGPAGGGGEAAPAHVADADLERGGYSKEQSITLMKAIRAILAQNLDVAQESLVSKSDVENETYLFRAACSELSTEVRNNQKLADEEMRQKRTLLQHEVDILTQSLNQELLTLNDNVRGMFNDRKMAVREEQKAGDSVIQQINYKISLHLSSDAKSEIEGLRWILIRRSVIGILFMAVLTLGTLRYGTYVSHAKQAEADRVRKQAEMIKMADGKRDHSSAPDAAEILAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPE2</accession>
    <name>A0A1B7YPE2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Decapping enzyme dcp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162341.1">
        <property type="nucleotide sequence ID" value="XM_018297525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPE2"/>
    <dbReference type="GeneID" id="28861632"/>
    <dbReference type="KEGG" id="chig:CH63R_02550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02550"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="129"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="399"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="736"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="794"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="909" mass="99354" checksum="3A0A5DE7B32B1528" modified="2016-11-02" version="1">MAEEKMQLEDCWLPHTPDDLGGIKYQPCVLSSFCRFAVWLTQSIGLDDLCVRFIINLPEEDLSSVARICFQIEEAQWFYEDFVRPLDPTLPSMTLRSFSLRIFQHCPLLAPFSVENHTKAFEEFLQYKTRVPVRGAILLNEAMDSTILVKGWKKGANWSFPRGKINKDEDDLECAVREVYEETGYDLHAAGLVPENRDDVKYIEVTMREQQLRLYVFRDVPMDTHFQPRTRKEISKIQWYKLSELPAFRKKGNQPQNDAAAAANANKFYMVAPFLVPLKKWVVQQKRKDAVKAANEAHFNPYSLHEEPLTEDDVWQTEPATDVSNRTPGLDTLEGATQELQRLLKVKPTAAQATSKPASPDVGSDKGASLLAILQAKNQAAAQGIPITQLPHTPLDHTIREAPLPHSPHGQHHPQQRAPLASYQAPPEFPVVPDGTPQSWAFNQSGNSGPVPPQAGHHDQSMMGGPSYVPHPPLRHPQPLPPQVQQTLLARGGFPDTTPPPPPKHAQGTVNQPMANAQFPQVHFQQQTQNILYRNKLPSAQLSNHSMALLGVLKSDTKTDNPDRAYQTGSQPFAPTPSGHDQPFDGIQGHGGVSAYVQPPVSNVGEQHQVNPAVNSRSQQPGDPLHRSTLLQMFKKPEIHSPPTNQPAELPANTASATLMKGLSTVKATNQGTHSPIFQGRVAQPVSSSPLSRPPQGVSDVSSQVNIQSLSLQPQGGRREHQSPQTITGYNSRAAENRVSSHQGTYSHPAVYNNKSPQMFSSQTRERGENLNKPGGPRAPAIASILGAAGADKPSSLASPPAASALPAPGALQQKSQMSTEQRQKLLSLFGKPQSPSPGPVFDLDDKGKTREMAAPDGSKRSRVASLASASGQGAPEGLSESRRGSQTPISPADRSFLLGYLASVANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPT3</accession>
    <name>A0A1B7YPT3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_02688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162479.1">
        <property type="nucleotide sequence ID" value="XM_018297663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPT3"/>
    <dbReference type="GeneID" id="28861770"/>
    <dbReference type="KEGG" id="chig:CH63R_02688"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02688"/>
    <dbReference type="OrthoDB" id="2830640at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="502" mass="57866" checksum="9CE47884AC8DE1B9" modified="2016-11-02" version="1">MDDYMFREHVSKCRQISEATHYVEILNYSARKRGFSMNSERLKPIDFQDPFYNTCEEHPLTMDEFDNFLHRRGAFEPAKVKEDVKLLNGIRLVLQKNAKHKDTFTPHTITFTADAYQSMVRAMRLPFRAIEGTSVVGPFFWCAYDQDDDDPTLPVPEIIFRKSDVRKKGKTRGWEIMLSHCFSNGITSGYVKGTPSSDIVAAIQHLTFCARQVGHPMLLPIIILSHDLSSQNDQKQRDARDWLRKLEHAVSMRNEIEDEEGYVSKDGYLEVDAISRDLVECHSQVLWKRPQAYLEIVKEIEAGLHKFKEKVPADHLTPDLDKLHRSMIARLDFYRLKLKGIENYQATTLERLHIQRSALYNLLSQRESKIQFQMAGEQRRLAHASKRDSTAMKTISLLGAVFLPGTFLASVFSMTFFDFGNGADPVISKELWVYFAITIPLTIVIVGGWIVFDRRREGKFASEDADLEKNIEHMEADIMAMMRKRTMSKANTWTSVTSPIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ88</accession>
    <name>A0A1B7YQ88_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162718.1">
        <property type="nucleotide sequence ID" value="XM_018297902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ88"/>
    <dbReference type="GeneID" id="28862009"/>
    <dbReference type="KEGG" id="chig:CH63R_02927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02927"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="259" mass="28711" checksum="06CC0021EEF0B7AF" modified="2016-11-02" version="1">MEESFVLVERERQRESRSRGSSIAAESSNTSRRAATIVDFDIANIVDDYRSHTARARRTDNPAHRDTWTTDLGFDGCSAKNRSVVVHYLSRHQTTDPASSLPFGKPPSTSAQAAATPWRPSSPVARPVPAPPLHRPHTHAHTPTTPSQTEAAAETQAPQMSDVKSLAKSLSAHPPDGRHARFHTLTHTHPYKHYATRRQCRAAQRNAPSGRSFPHRTRHCGYARRLDARPSTADVCRSATKGLYPDRWRLACSSSPMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQN1</accession>
    <name>A0A1B7YQN1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xylanase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162876.1">
        <property type="nucleotide sequence ID" value="XM_018298060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQN1"/>
    <dbReference type="GeneID" id="28862167"/>
    <dbReference type="KEGG" id="chig:CH63R_03085"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03085"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601835" evidence="2">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="69"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="395" mass="43929" checksum="A9F70E0650C707D4" modified="2016-11-02" version="1">MIFRRSHLVGLAVALAPLAVADDHPYVADSVCNCYLTNSSESYFTNHLFFDFRNLSQYARVPDLLTDWDASANAPVTSDYFNSDAWTSIWGIQNWNNTDKKGKDGNDATVDMVNSANNIYIEKNNDQDASSDTFMSMRTARLKGFQTSAEMETVSMGYHYVSVRMLARTLGDPGACTALFTYREADKYANVQEADIEVLTKDPENRIQYTNQPSFDSKGDTIDKSTQNGTMPSGTSWRDWAVHRLDWDKKDSTWLVDGSEVSSISFQVPRDPSRVMLNSWSDGGSWSGVMKVGDSAVMQIQWIDMVFNITTDESSEKRDLGLQQRHSHGPAGQLERRSGHGKCQVVCSIDSSDVVGQAVMLHNGTAPGRLLGQSSAVAFWLPVALMSAMVYHLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR42</accession>
    <name>A0A1B7YR42_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_03150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162941.1">
        <property type="nucleotide sequence ID" value="XM_018298125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR42"/>
    <dbReference type="GeneID" id="28862232"/>
    <dbReference type="KEGG" id="chig:CH63R_03150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03150"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="575"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="844" mass="93516" checksum="DD0E4340C730C865" modified="2016-11-02" version="1">MASYIYIASTPTADTGASLLLHFDHRRYLFGNLSEGTQRALTQRKFSLAKMETIFISGQTKWANTGGMIGMLLTIADVVEGSRREMQAQSDEKKKKARKQEAFERLEIHGAQNLNYSIATARGFVFRKGIPIRAMELYQDPRLANPGGSTPDWEDDAIQAWKIPISAGQPSSPSAYGKSRKRSHEVMTAEDDAAVATSQTTPATDVAADSATSEQQKITNREAVEAVVQEMFSSDWAMDQLYETKLSQVNLPATIFIRENGQIQKYKGPMPGDEGEVPDLDVLVRYPWPATKVRDLPDPERSTSAVCYVVKNRGRRGKFDPAAAKALGVAPVDFKHLTNGQTVKGKTGNDVTPDMVLGAPTKPVGFAIIDIASTSYIESFLGRPEWKNATLMDNVPAFFWILGRSVIDDARIQNFIRERPHIRHTIMAPDVSPNMVAMESYGLLHAKLRRIDPERFPPLQADNTVRDLSHIGSNVEAARVGMKAVLGAKIKAVNDDIVPFPTFKEASNIDGGALRMAAHAAAKVRKPAFLEEVQRTEQDIPNRDTEIIPLGTGSALPSKYRNVSATLIRVPQYGNYLLDCGENTLGQLRRAFPAEEVVKILRETRCVAISHIHADHQLGLASFVTAWAEATAALDHLPRLGIVGPLSIQNFLLEYNQMEWMDLRRLEFIRKHNIFPYGDGRLPEDSCTRLASVQLVPVRHCHHSYAVVLAWPSGLKIAYSGDCRPSDDLVEAGKGATLLIHESTFDDDKQGDALAKKHSTMSEALDVGYRMGARRVLLTHFSQRYAKIPLVEKRTTETGADQTVLMAFDQMRVKLGEFRQAQAFLPAIRQMLDAEEAPKADEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRE8</accession>
    <name>A0A1B7YRE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_03341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163132.1">
        <property type="nucleotide sequence ID" value="XM_018298316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRE8"/>
    <dbReference type="GeneID" id="28862423"/>
    <dbReference type="KEGG" id="chig:CH63R_03341"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03341"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="340"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="533" mass="58819" checksum="00B7E6A019F3383E" modified="2016-11-02" version="1">MVVKQVYHNPIIPGFAPDPSVVLVDGVFFLVTSSFHVFPGLPIYASTDLQEWKHIGNAINRKEQLSLEQATTAVMPLDTGNIMVASAGLFAPTIRHHDGRFYIVCTNTAHEGGSFATNNFYISTTDIWSGKWSDPIYFPFNGIDPSLFFDDDGRVYVQGCWAISRMEQPSCTIKQFEINIETGEPLSETREIWGGHARYDTEGPHIYKRGGYYYLLVAEGGTFEHHLLSIGRSRDIWGPYESCAANPIMTADGKPDEYVQNVGHGELFQDQGGAWWAAVLGVRNEDGHPPLGRETFLTAVDWPDGGWPTIAQPKMEFCRSSGVTGPGDVTTIPRSPAGVDHVYIRNPQLDNYELRGEGDERLYVLRAAQSNLSSPSGTSTFIGKRQRHIEASASVVLDLSSVAADKPVVAGLALYKDALRHVSLSYDFTSSRLTFEVVTTSKDKSHILSYPVRRSSQTLSLRTQTTAAEYKFSYQEEGGQWTVAGSVRVSDLVEREMTGPVFGLYAHALEDEGVGQGVVFRNFTVNGGTDWSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRY4</accession>
    <name>A0A1B7YRY4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_03440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163231.1">
        <property type="nucleotide sequence ID" value="XM_018298415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRY4"/>
    <dbReference type="GeneID" id="28862522"/>
    <dbReference type="KEGG" id="chig:CH63R_03440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03440"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="547" mass="59805" checksum="C464FF6D1B31C323" modified="2016-11-02" version="1">MSKFLGKFNGASTSATANKNGGDLPAAATYDSEVGRIEDAREAKRTIGVTTAIFLIVNRVVGTGIFATPGTIFALSGSVGLALFIWVAGMIIALAGTAVYLEWGTAIPKNGGEKNYLEYVFRKPKFLTTGLYTGYVVLLGWASGNSVVFGEYILHAANVEVDRWNQRAIGLACITSAFLIHGLALKWGLRLQNLLGSIKLIIILIIILCGFVALGGHVKLPEDQKPRNFENAFAGTTGSAYGVVTALYNVIWSYIGYSNANYALSETRNPVRTLKIAAPVGIITISILYMLVNVAYFAAVPREEILEGGRLVAASLFRNVMGSKAERALSVFVALSAFGNVLSVIFSQGRLVQELGREGILPWSRFFASNRPFNAPLAGLFEHWLICVITMLAPPPGDAYNFILNLISYPLAIINVFVSGGLAYLYLNRKEWNWNPPISATLPVTIFFMLSNVYLVIAPFVPPEEGQNVYESLPYYLHCVVGIAIIVAGGLYWVVWAKILPKLGKYELVRETVVDDIDGWERNVFFRRPYGESVGSEHNEISQEVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS25</accession>
    <name>A0A1B7YS25_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mpv17/PMP22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_00035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163372.1">
        <property type="nucleotide sequence ID" value="XM_018295010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS25"/>
    <dbReference type="GeneID" id="28859117"/>
    <dbReference type="KEGG" id="chig:CH63R_00035"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00035"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="273" mass="31056" checksum="61864597B7D35A34" modified="2016-11-02" version="1">MSWELSRRRIVRAVNSKYIYGRLPLLHAVIALIEMALVARLVSKFNQYYDERPLLTMMVTNAILGGIADTTAQTVTALRLKAVRKPGGLDKNDGVAIEIHDLDRKNPFYEKDLIPDSKHLPPPFDFERLTRFMAYGFGMAPLQFRWFKFLSTTFPMTKTSAFVPAMKRVAFDQLIFAPFGLLCFFSVMTVAEGGGRRAVLNKLRDMYVPTLKANFIVWPAVQIINFRLMPVQFQLPFVSTIGIAWTAYLSLTNASDEVDNRPAARDDDHIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSZ8</accession>
    <name>A0A1B7YSZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163687.1">
        <property type="nucleotide sequence ID" value="XM_018295325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSZ8"/>
    <dbReference type="GeneID" id="28859432"/>
    <dbReference type="KEGG" id="chig:CH63R_00350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00350"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="36231" checksum="E86D0D1227A54CEA" modified="2016-11-02" version="1">MGGLERRSFVTSQDRGYAPETPWHIHGSGILSLMRARGDRQLYTKAGRQIFWTMHNMIVSRHDRHANIHYANRNQQIQHTITNTPCPPEFDHWLNVIEQTLQPAEALFLHTGRYISSACSLLSRLIPIVRNVDLKRACAEYDQLLFECDLAELVMSEWMRTSPEYQVDPGPVHTYFWDSWRSARIKLHHMIILLANLVEHVPDCAFDCGALQSRRRLSAEIIAVSGRDIVDGIPPSLGGKSPASDPRSPATYLEAVRLVWPLSHVYVIPTAPRHLRIAAKAALLRIGKENGILSALRPRAGGALFPSEALKGMPVDDLGDGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTX1</accession>
    <name>A0A1B7YTX1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163919.1">
        <property type="nucleotide sequence ID" value="XM_018295557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTX1"/>
    <dbReference type="GeneID" id="28859664"/>
    <dbReference type="KEGG" id="chig:CH63R_00582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00582"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR15402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="354" mass="38823" checksum="BC372CF2E61575E0" modified="2016-11-02" version="1">MPTPESEMFLAQKPKVPPTFDGVDYDDTKAFKQAQDAIIREQWVGAMMLRLVGEELGKCYKKEGVNHLEKCGHLRVLVGPGGGALVETSFSIREGERRDEAMTVSRQLATHASCINSWSGPRDDNQQRKPAATPRRARPTPHNMICRTCLRRASALPRLQAPRATAALVIRPFSLSAPSRNAAAAPDDSTKTKATDVPPNLSSLKNDAPAPAPISSCPAGTVLNGLNYFKGRTDPVALRDEEYPEWLWTVLESKKVTVESADDLAAEMFSKSKKQRKAAAKRQKAIEAKLVASGDVEALAPKVPLPQQSINLPGEKGGDVEHNLHAATKRDELRKAMRTERKAKIKESNYLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU60</accession>
    <name>A0A1B7YU60_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Double-strand-break repair protein rad21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164106.1">
        <property type="nucleotide sequence ID" value="XM_018295744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU60"/>
    <dbReference type="GeneID" id="28859851"/>
    <dbReference type="KEGG" id="chig:CH63R_00769"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00769"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="6">
        <location>
            <begin position="707"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="795" mass="87762" checksum="99C5F9ADC050FB6B" modified="2016-11-02" version="1">MRPNSARTNPCPIPAPSFCLSIGTASRKRRPLHLDSPLLLTSSITLIAAHRAFAAIATGASHSSAFRDRDHLLSCRRASKFARVRPRPDRYIPNATRFPTTTRSRVYQSFRKPPLQPRRASLPIYLASSSSYFLLLFSYTFILLCSVAAMFYSETLLQKSGPLARVWLSANIERKLSKTHILQSNLPDSVEAIITPGQAPMALRLSGQLLLGVVRIYNRKARYLLEDCNEASMKIKMAFRSSDNHDMAVANLYANNREALLLPDKITPLDNLDLPPPPDAAWLLSQMDDVAATPVGRKGRVSHRDINLQEDFNNSQFLTQGDTLDDELELAPMEDLDLELDFGMDIDDRPTRMDTTIEMGRDAPLARSVEDDIFSELDIMPRGKDQPEREPSLGLALDFGDDNVRIADEEGDIQMGDDNEFQFPTGDQSLAPGFPGALDMPRARISESPLSEIDPEFAREVEEEYSRIQHTDLYEPDEDQERTVVRHPQRSKKRKILLPDEQTMLSSNHIKDQQANHGNILRAQSFLPRDPFVLALMEMQKSGGFVSNIMLEGRSAGWAPELRGMLSLEAVSRSSELKRKRDSGVADVESDHGATSKSPRLITEEEDVFAIEGVGFGNQSVAGDGTVLEIPADEEGIAFGGDDDDTARPISGQGSPMPDFDETTAPAVHPQDSGPVSIGTKHAVHILRDIFGPEAEHDAAKRKNTAVVFQDLLPEQRTTKADATKMFFECLVLATKDAIKVEQGEALGAPIRVRAKRGLWGAWAEREAGGEIAEEEEANQPEPAAVSAPAVAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVB9</accession>
    <name>A0A1B7YVB9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164507.1">
        <property type="nucleotide sequence ID" value="XM_018296145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVB9"/>
    <dbReference type="GeneID" id="28860252"/>
    <dbReference type="KEGG" id="chig:CH63R_01170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01170"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="84"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="296" mass="32327" checksum="CAE3681EDAA43A25" modified="2016-11-02" version="1">MWSGLIRRFSSDIPESYPHSGHSQESSHLAHAHTEPVSGAALKDGVNGVFVPSHINRTASPFRPPPLDPIVLSGFKDSTPPSARLLSHGVAEEIRIMLPERLRIMEDWKLIYSLEQDGASLTTLYQKAADYQGRRVGFVLVVRDDAGGTFGAYLSEYPRPAPKYFGNGECFLWRASTLTPLPPPPSADTTNLTRITTVASPTRSTFLDSDRPTPSPAPSESIRFKAFPYSGVNDYYINCETGFLSVGAGDGHYGLWLDDSLDRGHSGRSQTFGNEPLSDEGEKFGVLGVELWVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWV1</accession>
    <name>A0A1B7YWV1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_01696</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165033.1">
        <property type="nucleotide sequence ID" value="XM_018296671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWV1"/>
    <dbReference type="GeneID" id="28860778"/>
    <dbReference type="KEGG" id="chig:CH63R_01696"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01696"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601998" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="725"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="458"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="805" mass="84399" checksum="5ABE2E39DDE6457F" modified="2016-11-02" version="1">MRVSTSAGALAALSFVSSTSAASNSSTSSTNAILSDGYVSLGRYDAAYQKAKSFVATLDNAQKVSIITGQSVTGNATWTALNNKDGVSGINYQFYVSGFTMANALTMSWNRELIEQQFKAVGDEFYGVGYNLINGPEAGPLGRTPYGGRTPETFGADPYLTGIAMGKAISGMNSAGVIAGGRHFLLNEQETNRSSGISATTSNVYSSNADDKTIHELYSWPFADGVQAGMMAVMCGMTRVNGTLSCENNNLVSALLKKEMGFLGLVFPDVNSQTTSYGSANAGLDYGSSNYWTEDILNAGISNGSFTQERLDDMAVRNVIGYYHVGLDDGKQPSKAATTEYRDVRGNHSKLIRQVAGESIVLLKNSNVSGLGLPLQRPRTISLFGAHAGPALAGPNQPFSVQGTDSDVYQGHLASGTGSGQLSLPYLVTPFQAITSRAIEDNSMIWWLLNNTYTSSSSGGGGMSGGGGGGSPPDGMSGNSTGGGMGGSVGGNSTGGGMTAGGGGGGLGNLGQGTAMTPSFTNYAENSQVCIAFINSYSGEGADRSLLYDDEQDAMVTSVASNCNNTVVVVNTAGPRVLDAWIENENITAVLYSGLLGQESGNAIADVLYGDVNPSGKLSHTIAKSADDYPVSICYTEQCDFSEGVFIDYRYFDAKNRTVRYPFGHGLSYTSFSYGKVDAKVTNQTAADSKYPGGALVPGGQEDLWEEIISVKANVRNDGGVQGAEVAQLYVSFPAEAAQPPRVLRGFEKINLKPGAAGDVTFSVRRRDVSYWDTAAQKWAVARGKYTFSVGASSRDIRAVADITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVQ9</accession>
    <name>H1UVQ9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">CH063_04518</name>
        <name evidence="25" type="ORF">CH63R_04980</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="27" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CACQ02000308">
        <property type="protein sequence ID" value="CCF32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161201.1">
        <property type="nucleotide sequence ID" value="XM_018299955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVQ9"/>
    <dbReference type="STRING" id="759273.H1UVQ9"/>
    <dbReference type="GeneID" id="28864062"/>
    <dbReference type="KEGG" id="chig:CH63R_04980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04980"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CCF32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OBR12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="692" mass="76796" checksum="8803479C4EC9F5C4" modified="2012-03-21" version="1">MAELDTLDIIVLAAILLGTAAYFTKGKYWGVVKDPYANAFANANGAKAGKTRNILEKMEESGKNCIVFYGSQTGTAEDYASRLAKEGKSRFGLETMVADLEDYDYDNLDAIPSDKVVMFVLATYGEGEPTDNAVDFYEFITGEDVSFSEGNDPALSNLNFVAFGLGNNTYEHYNSMVRNVTKALVKLGAHKIGEAGEGDDGAGTMEEDFLAWKDPMWSALAEKMGLEEREAVYEPTFSILEREGLDASSPEVYVGEPNKMHLEGTAKGPFNAHNPYIAPIAESKELFSVKDRNCLHMEVDISGSNLSYQTGDHIAIWPTNPGEEVDRFLDLVGLTDKRHSVISVKALEPTAKVPFPTPTTYDAIIRYHLEICAPVSRQFVSTLAAFAPSEDIKAEMVRLGGDKDLFHEKTGAHFFNIARFLDSVSGGQKWTNIPFSAWIEGLTKLQPRYYSISSSSLVQPKKISITAVVENQTLPGRDDAFRGVATNYLLALKQKQNGDPEPTAFGLTYEITGPRNKYDGIHVPVHVRHSNFKLPSDPSKPVICIGPGTGVAPFRGFIQERAKLAREGADVGQTILFFGCRKSTEDFLYKDEWEQYKKDLGDKFELVTAFSREGPKKVYVQHRLKERSEEINKLLEKKAYFYVCGDAANMAREVNTVLAQILSEQRGISEAKAEEIVKNMRAANQYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVZ3</accession>
    <name>H1UVZ3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_00760</name>
        <name evidence="17" type="ORF">CH63R_11799</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CACQ02000335">
        <property type="protein sequence ID" value="CCF32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153614.1">
        <property type="nucleotide sequence ID" value="XM_018306773.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1UVZ3"/>
    <dbReference type="GeneID" id="28870880"/>
    <dbReference type="KEGG" id="chig:CH63R_11799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11799"/>
    <dbReference type="eggNOG" id="KOG4645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001999_2_0_1"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1055"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1334"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="970"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR05096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1359" mass="153233" checksum="E342257A0C83572F" modified="2012-03-21" version="1">MSTEPSPRAVRFSNGDDELRPDTTMPHRPVPVAVDSDNSASSADSHPDDPHALERQDEVGSLVRYQEGHIAGSMSNIVQAAVANGGTTRSLRSNASDGDASYANGTAATKIQRPSAPARTPSNTYAPAAHRRPQPAPSFVESVRASSRGRPRPSERFRQQERAYVQRLRQDHNDGYPFDGGYVNGINGISQGGDSDSEGETPSSEGPFDDRYDQETIMFYGNDDLQPSDEDLKDPTNRERLEWHGMLEAVLTGDVVKQEKKRLIGSNEQAVGKSGQKAELWLGIRSKVCGRHLPVQRRMVEEARATLDRTLDEIINFSVKGESEAGKPPYEQVKDVVKKIDKAESLYPSWTSLAAEHQSASSPLFQEASESIIAWYNTNELINTELAILKKWVGNEELDFTRTRQRSPVGNGISDESSFLDRLMKEDGLRSLYDEEFDDEKNKDAHKGMLPGISTVINKSKETLIRNFAAFQKRHLPPYIEELLTLISFPSRLIEEIIKVRLAYAKKVKESAQQNPMMQDQMISQFQLLLKLAIRIKLECLAVTQPEPGWELPPCIDESFDQVVLDALKYYFKMLNWKLSGNKNTFKEAELLFAEWDFANEIGSHLLGGDVEVAEQFSSLTFKAINRLSVTFEKELQVKPRESTAEMSKRYKQCLDSVRVRQRMLQRFSKMLSENYENASDFSIAFAPEKLQEFYDRLIVSGHFQVFTDLYEQEGIFIMASPSLMDRHDAIQSILGLSSPEQFAEDPTDPYLLILRPEGNPHWFGDVVQLSVRERSVDLKKGHMRLVAVGAQARLVDARRAFIDAVDMHVDLVVEQRSNLHKVNTRLMEIRRVAYKLSNNFMDSVEIIRKQTEGREVQELIQTCFVFATEFGQRSLLVMDSNRKQMNNLKLTKLALDWVSFICDDCIASDRKTFRWAVLALEFAMGMTRGRHILALGEEEYARLRAKVAGCMALLISHFDIMGARSNLAAQAEKERIEALVGQFKRLDKNRMLDDHEASKYITEQRLEELEKVDEIRRAKEAERQALGHVLEGNNEVDRSLAYLSSSATNITMRWQQGHFVGGGTFGNVYAAMNLDSGHLMAVKEIRLQDPKLIPTIAEQIKDEMGVLEVLDHPNVVSYYGIEVHRDRVYIFMEFCQGGSLANLLEHGRIEDEQVIMVYALQLLEGLAYLHESGIAHRDIKPENILLDHNGIIKYVDFGAAKVIARQGKTLVQDLSSTKPNKSMTGTPMYMSPEVIKGENPGRAGSVDIWSLGCVILEMATGRRPWANLDNEWAIMYNIAQGNPPQMPSTEQLSPQGIDFLGRCFTRDPKHRASAVELLQHEWIMTIRSQVVEPATPSDASSSAQSTPSSRSNTNDGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW08</accession>
    <name>H1UW08_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_04600</name>
        <name evidence="13" type="ORF">CH63R_07527</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
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        <text evidence="1">The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">May form a complex with LTO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YAE1 family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07527"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018295533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXE0"/>
    <dbReference type="STRING" id="759273.H1UXE0"/>
    <dbReference type="GeneID" id="28859640"/>
    <dbReference type="KEGG" id="chig:CH63R_00558"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00558"/>
    <dbReference type="eggNOG" id="ENOG502QTT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045430_0_0_1"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="109"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="368" mass="39863" checksum="397FB9BFC01AEDCF" modified="2012-03-21" version="1">MNTEDENLGPLVRLWGIRTEQLPASSATKADLAPFLIAVLQEAVPFIDAVAPKDGTARPNEWKAKGTKTFPESTAPVEQYERIISAVELEKEAARNQLPNNNSISTETWACRRSVHKDRPGKGTAAWEEFVKCFKDDHVEAEKAFTPNVMETREALMWDCKGVVVEEAGLLWEDFKVGVSEIKHKLGMPLKNRVFPELIVSAKARGVDEFVVVSMPVTDLAESDHGQLVKDKGVVVGAYVSVERVRRLPTGAIEWIMATASDAKGMLPVWIQAKAVLGVVSKDVALFLGWIAEEREQGTSVGKWTAVKGDGGGGEVRPGSNNRKASVALEDGESSTVQGRSPRQSVPSRNGKDLAVGGTNGTNGQVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1UY27</accession>
    <name>H1UY27_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_00884</name>
        <name evidence="18" type="ORF">CH63R_06406</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000568">
        <property type="protein sequence ID" value="CCF32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159231.1">
        <property type="nucleotide sequence ID" value="XM_018301381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UY27"/>
    <dbReference type="STRING" id="759273.H1UY27"/>
    <dbReference type="GeneID" id="28865488"/>
    <dbReference type="KEGG" id="chig:CH63R_06406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06406"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="282"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="80"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="716" mass="77641" checksum="3827C3C5B69CB3BA" modified="2012-03-21" version="1">MSNLNSWEDDPSAQDDNLSRQAQQQLNLNQQQNPQAGAFRPGASSFTPGVQAFQPGQQYGGYAPQYQQYYNQGYGGAAGAAGAGGFPQYGGQGQQAFNQYGQGNYGGYGQQGYQQAYGQGYPQYGQQQQQQQQNQPKPAPTIAKRPADATASGSDVPASQSQPTVKKEGGAKVLSIGGDAPKPKAKVLSIGGTVPPKKEEKKEEPTKAAAGAEAGAKATATKAIEKTGASTTKSGKTSPSPSSGRSSPSEGDKKAAVRDVDAVQKEQTADVDEATLKEIYGKEHVNIIFIGHVDAGKSTLGGSILYNTGMVDERTMEKYKKEARELGNPSWYLSWVMDLNKEERSQGKTIEVGRGYFETEVRRYSILDAPGHKTYVPNMIGGASQADVGILVISARRGEYETGFERGGQTREHAMLAKTQGVNKLIVAINKMDDATVEWSHERYQECTSKLSQFLKGTGYNLKTDVFFIPVAAQQSINIKERIPKGTADWYDGPSLLEYLDGMKALERKVNAPFMMAVSGKYRDMGTMIEGKIEAGVIKKGMSLVMMPNKQSVDASAIYGETEEEVQVAQCGDQVRIRLRGIEEEDIMPGFVLCSPKRLVHNVQTFEAQIRILELKSILSAGFNCVLHVHAAIEEVTFAALLHKLQKGTNRKSKLPPSHAKKGDSIIARLQVIGGAGSVCIEKFEDYPQMGRFTLRDQGQTIAIGKITKLITDETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UY47</accession>
    <name>H1UY47_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05181</name>
        <name evidence="10" type="ORF">CH63R_13714</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000572">
        <property type="protein sequence ID" value="CCF32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151006.1">
        <property type="nucleotide sequence ID" value="XM_018308688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UY47"/>
    <dbReference type="STRING" id="759273.H1UY47"/>
    <dbReference type="GeneID" id="28872795"/>
    <dbReference type="KEGG" id="chig:CH63R_13714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13714"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_1_3_1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="143"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR02488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="586" mass="64043" checksum="D77664E13CD23C1D" modified="2012-03-21" version="1">MTETNNTTQNEARHGDPSTGPRRTTLRQEVEKAISAPAEKEAQEKQLDSSQHSICSDDTDSSSGHGERVHQSLRSATSQSLSRTISEVRDGIENRRDLELGPPSDLEKTPTTRNPQDPNLVTWDGPDDPGNPKQWSMKRKWAAVFCISCFTLLSPVSSSMVAPALEAIGDEFNIASSFEQALVLSIFVLAYAIGPLAWGPLSELYGRVIVLQLTNLFYMFFNLGCGLARTKSQIIAFRFFAGLGGSAPLAIGGGVLGDLFEAEQRGKAISIYSLMPLLGPAIGPIAGGFITQNTTWRWIFYSTTILTAVIQFIGFFVLQETFAPVLLARRKKRLIKETGNNALHTDFDHPDRTFARTLGIALTRPFRLLGTQPLVQFLALYMMYLYGLMYLVLSTFPALWTGEYGQSVGIGGLNYISLGLGFFIGAQTCAPLQDRIYAALKRRYAPDGGPGRPEFRVPMMLPGALLVPIGLVIYGWTAQHHAHWIAPNIGAVIFSAGVIVGFQCIQGFLVDTYTKYAASAVAATTVLRSLAGFGFPLFAPSMYQRLEYGWGNTLLAFLGIAIGWPGPFLLWKFGPGLRKKSQFAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1V290</accession>
    <name>H1V290_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_06360</name>
        <name evidence="4" type="ORF">CH63R_14462</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
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                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
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        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
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        <text evidence="2 8">Belongs to the universal ribosomal protein uL13 family.</text>
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        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="179" mass="19912" checksum="4282C53CD8E015B2" modified="2012-03-21" version="1">MSQTIGLTRLSYSRVWHHVSASAPHETLSTQPGVTPPSLGRLASRIAVLLMGKHKPTWDPSTDCGDYVVVTDCAALHVTGRKKWQKTYYRHNTRPGSLQAVTMDVLMAKHGGAEVLRKAVSGMLPKNRLRAPRLARLKAFEGEAHPYKKNVIRFGDVPVGQHGWEEQVKAIREADSERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4T3</accession>
    <name>H1V4T3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07066</name>
        <name evidence="8" type="ORF">CH63R_10528</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001455">
        <property type="protein sequence ID" value="CCF35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154926.1">
        <property type="nucleotide sequence ID" value="XM_018305502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4T3"/>
    <dbReference type="STRING" id="759273.H1V4T3"/>
    <dbReference type="GeneID" id="28869609"/>
    <dbReference type="KEGG" id="chig:CH63R_10528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10528"/>
    <dbReference type="eggNOG" id="KOG3124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_1_1_1"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF27">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="31728" checksum="E332B2CD2EDA2222" modified="2012-03-21" version="1">MDSLKDLTLCVLGCGNLGIPILKALLDNAESASSTLPITRFIACVRSESSEMSLKERFAAAGDKLVVSRGDNAAALQKSDVVVLGVDPGDVEAVLSQPGTKEALGDKLLISVAAGWTRGRLETTIYGSETTSENAAGRAWVVRTLPNIAAMVSQSLTAIEISEPAVPARYLDLTEAIFNRIGKTVQIAPKLMNATTALGGSTPAFFAVICDALIDAAVAVGVPRNLAHIMTFQSMLGTATLMQNGLHPALLKDQGTSPEGCTIGGLMVLEEGAVRGHVGKALREAVTVARLMESQPHVNDTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4V1</accession>
    <name>H1V4V1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_07075</name>
        <name evidence="6" type="ORF">CH63R_02552</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001461">
        <property type="protein sequence ID" value="CCF35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162343.1">
        <property type="nucleotide sequence ID" value="XM_018297527.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V4V1"/>
    <dbReference type="GeneID" id="28861634"/>
    <dbReference type="KEGG" id="chig:CH63R_02552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02552"/>
    <dbReference type="eggNOG" id="ENOG502RYRY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058864_0_0_1"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497585" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="286" mass="29754" checksum="ECF02FF390024FF8" modified="2012-03-21" version="1">MKAAQSLALGLAVLAPLASAWPKWLPDVDALVVRQNDESSAPAATETPASRTGATATPTATGTAEGTRTGGARTTNLNTAQGSTGTGTARGTQTGTGTRTGTGQSKSTAFDETDPQGSVVMITPAATAQSINLYKIGDFVTWGWNYTNLQATPTAIDVLVSCSSMAQTWTLTQNMSFAQPASFTWDSSVQKTDASAPLRNDEYTLVIYDAESSVSATAAAGYLGVSNSFKFGMYLPQEYKPLNEWNCAVCKSAAPSLNSKAIGMAVGMSMVTVASFTWFVAGLGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAJ7</accession>
    <name>H1VAJ7_COLHI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_01662</name>
        <name evidence="2" type="ORF">CH63R_01863</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002379">
        <property type="protein sequence ID" value="CCF37250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161654.1">
        <property type="nucleotide sequence ID" value="XM_018296838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAJ7"/>
    <dbReference type="STRING" id="759273.H1VAJ7"/>
    <dbReference type="GeneID" id="28860945"/>
    <dbReference type="KEGG" id="chig:CH63R_01863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01863"/>
    <dbReference type="eggNOG" id="ENOG502S1FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013566_0_0_1"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF37250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13137.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="892" mass="97181" checksum="CC1C5E6306317403" modified="2012-03-21" version="1">MAPTFRIHRPDVLASLPRPLDHTKGQYHIGEVYTQKPGSKKRKRLEVVVGVDGEAANIYHVPSSGLRTSYPIPPQESFTCAPHSIRYQGADASGSGRNNYTYLSTQDSTGAKVTLCRDVIDVTGKTNSTSVSQRVRHKSPITYLFTSSAVDTTVVSDSPQAERGDVLGLCRDGQVLCLDGEALEQKWSASSYSLCKDLLPSTVSKYEVEFSLHAAASEILNGLFQGRQDAFGSFGRLIDPKTFNPDVLTIVVRTNTEDTTSRFLIILGVLPTVASQPLVQLHVTPLPSQDDIATESAAYQLHTQSGKLLQLCGPVLRTYDLTSAVPKLQGRLPLPELTSFLQLSEHSVLCLSNNFASMLNPTFHSVQASTAIELPESTEQQKPTLITFLSKLDMAVAVVGNTLVSIQIERPKSHGKEGLLIDSIGKGLPRSDRVPASLPKTGNTTFETYLPGTLSDEYVKESLADVEKADGYLLAQDWKAFEGLLAQRFGVAIDQEAEVTGVQTPDWKWLERSDKYPAVDRRWVLYAISRVFSMDVQAAEGGLLRCMLPASNVMIYLIAAGHLTNANMSAAFKNELIEAASKESIIDKLVQRLVDMDPALELLLNYVSATKLGEKELLLVIRIIMRSLDQQSRLLPPAPTETKEEEYVAMEIDLLEKELELAEYHLGDDSNLRARALTTAFEKLSNYSSVATVRALRETFSPTEVLSLIHLLRVQLIGSAWTSRYVDTTNFDKDEAARAPPDGAISLIAELLSRCIDSVGPSGWLTNGTSSSGDRADAADFITALKLEVSAALEGLNEAVYLDGIVGEAVQYGRAVRAGVKTGPSGRAQVLAKPVSLDVESSPHLPLGLVSKQNVSNIKIVSGGEVLERSSREKGHLLSQKVKAYSLEKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDG0</accession>
    <name>H1VDG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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        <name evidence="3" type="ORF">CH63R_07619</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
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                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Shenoy N."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
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        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="555" mass="61499" checksum="143ED1D0B6DE8F73" modified="2012-03-21" version="1">MDKDYRGGGPLNDVESKHAGESYPRDVNFAALSGDPNSLINSQDQLQRGLKSRHIQFLALGGAIGTGLFVGSGSILSTVGPAPLFMGYLSMMMVVWNIMNNLGEMATYLPLKGISIPYFVERFVEPSLAFAAGWNYWYAYAMLVGAEASAGAILLDYWQTPVHPAVWITIILLVTLALNIFAIEIFGEAEFWFASIKLITILGLIMVSLVIILGGAPDEGRIGFLYWYDPGAIIPYMAEGNTGRFLAYWTGFVRAGFAFITSPELIALAAGETIAPRRNIPKAARRFVWRLAIFYGIGSLMIGAITPSNDPRLLNPNSNAASSPWVIGIQRAGIGGLNHVINAAILTSAWSAGNAFLYSGSRILYSLALNKQAPRFFARTTKRGVPYTAVLGTWSIALLSYLTISSGTSTVFTWFMNISTISGFIAWIVVMITYLRFRKAMTYHNMMHRLPFRTPLQPYFTWFILGLLVILTLTNGFQVFFPGEWSTSDFLAAYITLPIFFVLYVGHKIWFRTPFARRVADVDVTTGVAEMEAMAELDEEPIPKNMLQKVWFWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VH05</accession>
    <name>H1VH05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_10338</name>
        <name evidence="2" type="ORF">CH63R_11610</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003537">
        <property type="protein sequence ID" value="CCF39508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153425.1">
        <property type="nucleotide sequence ID" value="XM_018306584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VH05"/>
    <dbReference type="GeneID" id="28870691"/>
    <dbReference type="KEGG" id="chig:CH63R_11610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11610"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCF39508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="59775" checksum="B011F591F077BDE0" modified="2012-03-21" version="1">MRQTTWDRMVVVPLSFADFQQHYGSIRVERRDQMAREETKERKAWLATSNMIRDAENRELDDLKDIFSCYGFCAKPFFRFPQDKPSVQKRPLDYTFYAAPVPRDENSLWYSLAILVEDKPTDAKWIKGKVAHWFYENLMRPRSERFRMYHHLLAESVDCVDEDDANDWGMMDLLRCLNRNDTEAGMPREAGFHEMLHLVADFLDTEVITFTRPRFPSTYNAGERVMKQWLQENPYEMRVYGNQSSQETYQLPRFQNRKQILLVTDPELRHFQPVVRVTPEMPRYEAGDRSFHGHYLPTGGFEVWDRHMPMPWWPGFRWDADNRRWTGDWDDDDLRRRITIYQKLQMKPSDITTGNIIHSVSKSQLQGPYFANEPAGHLLQGLQTMYNLRQSYVGDADTDRKALFRWSKQSRLTWTAEAPSRDQPLDPAPRLRDFDARIGSTQFPARFPSKRQWDAMASGGRDYPEQINIGRHEDCGWLRLEATETENRRPDWHDNKRRRKVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIM9</accession>
    <name>H1VIM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10747</name>
        <name evidence="3" type="ORF">CH63R_10177</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003861">
        <property type="protein sequence ID" value="CCF40082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR06057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154575.1">
        <property type="nucleotide sequence ID" value="XM_018305151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIM9"/>
    <dbReference type="STRING" id="759273.H1VIM9"/>
    <dbReference type="GeneID" id="28869258"/>
    <dbReference type="KEGG" id="chig:CH63R_10177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10177"/>
    <dbReference type="eggNOG" id="ENOG502RES8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142375_2_0_1"/>
    <dbReference type="OrthoDB" id="5239281at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40082.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="149" mass="16015" checksum="7D49C61B27904D19" modified="2012-03-21" version="1">MPPKKNPTSEGQGSNFTENEVTFVKAVFDSMNSRPDVDFAKVATIMSLANAKCAKDRFRTISKRHGWSSTDGSGGASPSKGALGAKNTSKVMKTPTKKKGTAQKKKQTKKESSSESDNDDDVSSKLESDSDGQKAAKDELMQEDSSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK22</accession>
    <name>H1VK22_COLHI</name>
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        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">CH063_11106</name>
        <name evidence="10" type="ORF">CH63R_04550</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF40575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018299525.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VK22"/>
    <dbReference type="STRING" id="759273.H1VK22"/>
    <dbReference type="GeneID" id="28863632"/>
    <dbReference type="KEGG" id="chig:CH63R_04550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04550"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_059606_2_1_1"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
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        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="182"/>
            <end position="200"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="262"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
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            <begin position="19"/>
            <end position="31"/>
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            <end position="294"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CCF40575.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12254.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="294" mass="31643" checksum="B4C0480BEBABC7EA" modified="2012-03-21" version="1">MSRSGSGYDAVVDVDDEGDLGHTDLQDDLEFHSSNFQDSTPGARKAPASGLPPPATASPGSSKRFLWSINFYAQYFDVDTSAVLSRCWAALYPRANFLDVLEGNPDLYGPFWIATTVVLILFLGGTISQYLASTGTGPFAYDFKLLSGAAGLIYGYTLFVPVALYLALRYFGSDSANLLEQWALYGYANLIWIPVALISWSPINILNWVFVAIGCGLSIAFLLRNLYPVLSATDHQTSKILLVVVVALHLGLSLAIKILFFAHNSPVASKDPTAAQPPAAAPPADGQPPKPAFF</sequence>
</entry>
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    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02004523">
        <property type="protein sequence ID" value="CCF41159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158589.1">
        <property type="nucleotide sequence ID" value="XM_018300739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLQ6"/>
    <dbReference type="STRING" id="759273.H1VLQ6"/>
    <dbReference type="GeneID" id="28864846"/>
    <dbReference type="KEGG" id="chig:CH63R_05764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05764"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="277"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF41159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="400" mass="41514" checksum="00050FFD9B000D7B" modified="2012-03-21" version="1">MANLPPVYIVSAARTPVGSFLGSLSSLSATQLGAHAIKAAVERVPQIKPEDVEEVFYGNVLSANLGQAPARQCALGAGLSQGVAATTVNKVCASGMKAIILGAQTILTGNADIVVAGGTESMTNTPHYLPVLRNGAKYGDQTLVDGVLKDGLTDAYGKKEHMGMAAELCAKEHELTREQQDEYAINTYKKAQAATEAGIFSTEIAPVEVSGGRGKPNVKVDRDDEVKNLNVDKLKAMRPAFIPNGGTVTAPNAAPLNDGAAAVVLMSEAKVKELGVTPIAKIRGWADAAREPERFTIAPALAIPKAIKHAGLTEKDVDFYEINEAFSVVALANIKLLNLDPETVNVFGGSVAIGHPLGCSGARIVTTLTTVLREKKAKIGVAGICNGGGGASAIVIESLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLW5</accession>
    <name>H1VLW5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_11569</name>
        <name evidence="6" type="ORF">CH63R_09542</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004565">
        <property type="protein sequence ID" value="CCF41218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018304516.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VLW5"/>
    <dbReference type="GeneID" id="28868623"/>
    <dbReference type="KEGG" id="chig:CH63R_09542"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09542"/>
    <dbReference type="eggNOG" id="KOG3178">
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    <dbReference type="HOGENOM" id="CLU_005533_5_0_1"/>
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    <dbReference type="Proteomes" id="UP000092177">
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
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        <property type="entry name" value="COMT_C"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF8">
        <property type="entry name" value="O-METHYLTRANSFERASE AF390-400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
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    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="255"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF41218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="426" mass="47764" checksum="C56DE8B2831E920C" modified="2012-03-21" version="1">MTSAAKPSTANMTFATKPSIAENGINGVAALSVKQIISALDGVTLDTCDGSEEARYQLLEASRRLIARLETPFERMWYHTWVAFNNLAIFRIMTDLGLWEGWRAAGSEEASLDELLGYCKRDCDKSLFRRLLRHLTADHMLQETGVDRYKPTRLTIELGDSSTPTAAAVRGAIDHQIPSTTHFPSFLASTDYAEPRDHDATNYVSLDPDNLGLFARCQATPSKQESFITCMQGVAAMKTPWTRIYDTRELLTGRKQGTPLVVDVGGGHGRDLARVLESYPDPEEGDLVLQDLPEVIRIAKPDEKGRIKCMEHDFFEKQPVTGARAYYMHTVLHDWDDERCRQILRSTAGAMTPGYSKLLLHETMMPARGANWYHAMVDVCIMHLVSAAERTEEQWRALLASEGFRIVKIWHSNPSVECVIEAELAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNE0</accession>
    <name>H1VNE0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_00410</name>
        <name evidence="5" type="ORF">CH63R_00764</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004902">
        <property type="protein sequence ID" value="CCF41744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164101.1">
        <property type="nucleotide sequence ID" value="XM_018295739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNE0"/>
    <dbReference type="STRING" id="759273.H1VNE0"/>
    <dbReference type="GeneID" id="28859846"/>
    <dbReference type="KEGG" id="chig:CH63R_00764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00764"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011302_3_0_1"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
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    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF41744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="62007" checksum="1EBF9A9FC3B6F9DF" modified="2012-03-21" version="1">MPVLRPTTEWGHCMPPESDYGITTYAPGWDSAIKIRDGDPATMARIVHLYPRFGPFGPVARALKAICAKIQTPEGHGALYFTSPVSFAAVRAHALHPYRKQHVLVERDLGYRCVDVGDVRLYLVTYPMPKTPGVIGAWQNPGFGVSIRLAEKLLRDLDSLKEVGLEADLPPPSTEFLPEGEAHGKLRGRIAGLLRRAAIDPENARAESKDVFLYPTGMAAIAAANRTIQDYRPGSVVVLGCAFRSTLQHLEESSPRGYKHFGPVDAKGLGVFESWLDEEFVAGKGVSYVFAEFPNNPLLASIDIGRLGKLAEKHGFMIVLDDTVGSFANIDVLSEADILVSSLTKSFSGYANVMGGSTVLNPLSPHYPALSPLWYETYHNELYIGDAEVLLSNSDDYLPRTAILNRNAAAMAKHLHAHAKDPSTPVARVLYPSLLPDYEVYRARLRKPTPELPEPAAGCLMSVEFDSVAAARAFYDRLAFYPGPHLGAHRTLSFAYNLLAFSKHPDEAAYHRSYGILEEMVRISAGLEDVQDLLDTLDDALVAAREAKDKLAEGPRTLEAAAGLGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPF4</accession>
    <name>H1VPF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentatricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_02757</name>
        <name evidence="8" type="ORF">CH63R_02535</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005146">
        <property type="protein sequence ID" value="CCF42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162326.1">
        <property type="nucleotide sequence ID" value="XM_018297510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPF4"/>
    <dbReference type="STRING" id="759273.H1VPF4"/>
    <dbReference type="GeneID" id="28861617"/>
    <dbReference type="KEGG" id="chig:CH63R_02535"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02535"/>
    <dbReference type="eggNOG" id="ENOG502QSY4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014304_2_0_1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="645" mass="72233" checksum="E3103A013450569B" modified="2012-03-21" version="1">MLSCKACLRRAIQPLSTKASFVETSATVSTLQHGLPPHLQLQQRSQTTVSRAAFMKEARRSPRDTDNADDVAEKNRKRKMDWAVDQHLKHMDDPYNIAQHVEATLKKGRFDEALLLVQRSSKDKQVAVAWNHLIEYKVRDKSVNAAIKLFNDMKKRGQQPNDRTYTILLTGCAKSLDPKAAVPKAVAIYNSLLKENSAVRANSFHLNAVLQVCGRAGDVDAMFSIAETADARAGRKTTAYTYTTIINALRFEAENPEKQRSQSLQEILDTMAQMVKRCKAIWEEVMRNWRKGTLELDEDLVCAMARVLLLGDKKDQANIIPLLEETMSVRDLACKNPAKDHALRMNEGMKGIAAAVGTAGSAQQKAVPSTKPRINYAIPRSNTLSLVLTTLLQNRQAKLAVQYWNLFVYYYGLEPDSDNWNQLLRIYERNGSSRDAAKVVQKLPDEMLVPIMYRRALSACVNDKMNQKAFENATAVLERMTAHVAASKGTTPLDVRALHIYLKVGLSSNFQFRQVAKSGEVEEARRAYGEQLAAAVNNIWAPFTSAKDAMLKKKPKAGGKPSSKTSQMHGFAVKELIEIARNMISAVDKIVNENRLADEEAVEALKQKRNKLNRFVVEFTDPNQQKEEDLVVTKNTPMKDGEGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQM1</accession>
    <name>H1VQM1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_00429</name>
        <name evidence="19" type="ORF">CH63R_13695</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="CACQ02005457">
        <property type="protein sequence ID" value="CCF42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150987.1">
        <property type="nucleotide sequence ID" value="XM_018308669.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1VQM1"/>
    <dbReference type="GeneID" id="28872776"/>
    <dbReference type="KEGG" id="chig:CH63R_13695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13695"/>
    <dbReference type="eggNOG" id="KOG0803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000471_0_0_1"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057030">
        <property type="entry name" value="TPR_Rkr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23280">
        <property type="entry name" value="TPR_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1567"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR02469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1629" mass="179505" checksum="25EC4B63EEC2530B" modified="2012-03-21" version="1">MSRAFGKGGRSSGARGFGSPASAFGGFSSTPGSGLSYLTEPPDLSSISDANAVVSFKNTLKKDATTKAKALEDLLAYIQAHPFEKDGGAEEAVLEAWVQIYPRISIDNSRRVRELSHTLQLELMKSARKRMEKHVPKIVGAWLAGLYDKDRVVSRAANDGLSSFLNSPEKVALFWKKCQSQIMAYATDAIQETKDTLSDERSTTADDAEAKYLRVVGASISLVLGLLQKLEPVDIQREEEAYDTFFTEEKVWKSVVMGDPSVRRSACQLLWTCLDKRLESVSSQLPRLKKSFIAEGLKSNQTGSAVEYVRVLTKLTSKFPEIWTSSSEKKTPITRLNGFLEKGSHNSSAKYWEHLEELIKAIPAEHYTIEASADALKSMKTGITSREEPRMNATLAWTCYVRTTKHFLQGLPSDGSRAKLVQDYIFPLLEHFLFPTPENSSWEIGGAGRLDVLGEVYDVAVDSSSPDLIQVVTEKLENLSSAFCTRISNSLPEVSKDYERSQEAVSSEGNRWFTLVGQVQKNGQSSAELLVRPSKAIITSSLNLLANRNLKPYGAAGVVYSVGKNAPQLWEDAEAAHALEQFLVAQGRDRMDVLMASRSAAALLNCVNVLGTLKGQETAYATIWKTWVDALLDLSDEKLAAKGVERLVASQQASTLAKAHEKLQSFLVAKCSGAARGESDSWSLFEAVFGNDTVTESTAKELVDNSISALSQDKQNSLQALRALEIVANNKPGLLSQDESTHMAVVTELLGLAELNDRSISPRATSLRALLEQPTDGTSPVVAIIQRNLEEADQQSLGIETLVQQALQAARAGSISTEDLFPSTNVWMQQLSIFFHGSLNPSLSITSDLKGAHFLVQAPEQTQRIRARRDRDGYSIPARMASYTSKLLSSDISVSNLPESFQVELLYLLCVSIQMVSDQITLMDENKLFLSLEVGDALASAESFVSATRVTINTIAEEAKGWRDGSEAGSTKLIHSLIAIMTQETKELTSLGVYSARALSELIQTLTEKHGFPATGDEKINQLATLKATPPTILAATAVLVGFGESLESSKTVNMLCNRLVSDIAGASVEPEKAEKTLQILVLLNACLQVYEVGEVPVANNRIVFAVRQITSWMDDTLNVTPALSTEICRALQRLLPSMKDVYGSYWEKAIEFSTALWAKASDDRLDDSLPYIHTSLRLMTVLETMSEPNDDLADALKEFAETKSLSLIELLKLDRAKSTQPLEIVDAIICRQVNKIPLKHVNDLSDLYGLIAADSRSIQTAAFNLLHYALPAQQEELSVNVLLEKTDARLPDELLSLLLDAPTLERYPDEVLAQFPLAIRSYLLSWHLVFDAFSTASLKVRNDYTEHLKTENYIAPLLDFTFDVLGHSAAHPLNLEREGLTTQHITSYNVSLADAESDERNLHWLLVHLYYLTLKYTPGLFKTWYLACRSKQTRIAVEGWMTRYFSPIIVSDALDEVSAWAASQEPPADDDEKELVVKVSKSGKEITAGYEVDESMASIAVKVPASYPIEGVSVVGINRVAVSERKWQSWLLTTQGVITFSNGSIIDGLSAFRRNIVGALKGQTECAICYSIISTDKKMPDKRCQTCKNLFHRTCLYKWFQSSNQNTCPLCRNPIDYLGSDTKGRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRC9</accession>
    <name>H1VRC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arrestin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_02923</name>
        <name evidence="2" type="ORF">CH63R_08333</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005645">
        <property type="protein sequence ID" value="CCF42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR09568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018303307.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VRC9"/>
    <dbReference type="STRING" id="759273.H1VRC9"/>
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    <dbReference type="eggNOG" id="ENOG502QSAC">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
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        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="429" mass="47406" checksum="E5E9A2775534580E" modified="2012-03-21" version="1">MGEARSAAAKLIGMPTKEDMTILIDHHYTSKVYTCGSTVSGILKIVPRCDVRFDLVRINLLGSAGIHREHIYVTTHRTHLFLRLDMPVPESTYPTPRVYRAGTTYTIPFKFTVPHNLPENSCRHPVESDSIRSRHLHLPSSLRGWDKDDLSPEMTIVKYFVRARALELIGGEGKRIPVVKMEAEHALKLLTASPEDPPMIIARHNAHFALEEARTLRGNILSGSSGRITARSSQPEAIRLNADGHGARGSSVHIEFIFKPSTAEALPPEVTVNSAKIMAHTWGSPQPIRDLPEMGSGVEPFVLSTRVVMNSVSTASWTTHVDPADRETAGKSHRHDSPVTHKTSMKISFRLPTLTHVFPPTFYSCLLSRTYCLTIGLSAGGRRLRLILPVQVAMEPQAEHTETSPDDELPTWQEACGSIARGCYADAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSM0</accession>
    <name>H1VSM0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase ucpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12989</name>
        <name evidence="4" type="ORF">CH63R_08660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005943">
        <property type="protein sequence ID" value="CCF43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155657.1">
        <property type="nucleotide sequence ID" value="XM_018303634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSM0"/>
    <dbReference type="STRING" id="759273.H1VSM0"/>
    <dbReference type="GeneID" id="28867741"/>
    <dbReference type="KEGG" id="chig:CH63R_08660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08660"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="28076" checksum="FDDCE48F6E111C5E" modified="2012-03-21" version="1">MLNLQGKVALVIGLGQSGSDGWGIGAACAVTLAKQGALIFGGNRTVESTTKTRTAIEEAGGVCDVVATDATSSESVRALVDACLARHGRIDILVTNVGQSQPGCPATMAEATWDAQMDLNLKSVYLACHHVLPVMAAQPSGGSVVCVSSIAGMRYIGKPQVAYNTTKAAVMQFVKATAVIYAGKGVRLNTVVPGLMDTPYTKGLSQRFPQEGGYEAFRKMRDDQVPMGRMGDAWDVANAAVFLASDEARYITGQKIVVDGGITSSTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSQ4</accession>
    <name>H1VSQ4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_13021</name>
        <name evidence="8" type="ORF">CH63R_10361</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005967">
        <property type="protein sequence ID" value="CCF43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154759.1">
        <property type="nucleotide sequence ID" value="XM_018305335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSQ4"/>
    <dbReference type="STRING" id="759273.H1VSQ4"/>
    <dbReference type="GeneID" id="28869442"/>
    <dbReference type="KEGG" id="chig:CH63R_10361"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10361"/>
    <dbReference type="eggNOG" id="KOG3380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101888_0_0_1"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="202" mass="21386" checksum="A7289C6F1DB8BF25" modified="2012-03-21" version="1">MSIIQQHTSASLSDAWRTINIDALQEDSACNFDTSTLHPPQPEIGEDEVRQLAGQVRQLLRGGDAEGALRGCLEFPVYNGPDAAKDAHLQTITEVLQSIKASEMTPLLKSIYGSAGGPELLDVLMKYIYKGMAGSAASSGGLRSPPPQQAAPGGFSQIGGRPGGTNENVGSAMSVLLSWHEKVVDVAGLGTIGRVMTDWRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTG1</accession>
    <name>H1VTG1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Preprotein translocase subunit Sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03093</name>
        <name evidence="4" type="ORF">CH63R_00674</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006168">
        <property type="protein sequence ID" value="CCF43519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164011.1">
        <property type="nucleotide sequence ID" value="XM_018295649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTG1"/>
    <dbReference type="STRING" id="759273.H1VTG1"/>
    <dbReference type="GeneID" id="28859756"/>
    <dbReference type="KEGG" id="chig:CH63R_00674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00674"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_0_0_1"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="26071" checksum="749FEF8D5D6E3ACB" modified="2012-03-21" version="1">MFDVDWMSLVLPFAYLTVLGGVFMTFSTIYRKRKATQSANLAPWFGPHLQRNIYLSLLHLESPEEGQEKAPKIPHTVIKAALLRRAVEDIHRLVQIRSAKQACSTLLQRGSVGDDLWQRFQRAEKEMEDELRDVVMEANALAPNWGQSIFQSANEIAANTIARSRLEEVSNTVEQEKAWWEKRRATIQTDFMKELDESEKSSTAPPSVDGDAVLVDSGAANTPSKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTS6</accession>
    <name>H1VTS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03120</name>
        <name evidence="3" type="ORF">CH63R_11184</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006246">
        <property type="protein sequence ID" value="CCF43634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018306158.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VTS6"/>
    <dbReference type="GeneID" id="28870265"/>
    <dbReference type="KEGG" id="chig:CH63R_11184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11184"/>
    <dbReference type="HOGENOM" id="CLU_2904082_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04481.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="62" mass="6533" checksum="A6D842B05B6E2182" modified="2012-03-21" version="1">MERTREATSQLEADYDVQTDTAAWGSKQVTDMCLPSTAGGVSEHGSSGYSKAATVATRQVPP</sequence>
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            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007388">
        <property type="protein sequence ID" value="CCF45046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VXT4"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04901"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="OB_NMD3"/>
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            <begin position="9"/>
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    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
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        <source>
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    </evidence>
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    <sequence length="498" mass="56234" checksum="D7E8FFB93AA75973" modified="2012-03-21" version="1">MSMHATILCCNCGAPIDGTTAAGALCYDCIKLTVDISQGVQREATLNFCRDCDRWLLPPSSWVVAAPESRELLALCLKKLKGLNKIRIIDASFVWTEPHSRRVKVKITIQDEVQTGVLLQQAFEAIYIVAYQQCPDCAKSYTANVWRASVQVRQKVLHKRTFLFLEQLIMKHGAHRDTLNIKEAKDGIDFFFSARNQAEKFCDFLNSVVPCKAKKSQELISQDVHTSTKSFKFTFSVELVPICRDDLVAMPIKLAKASGNISPLVICHKIGTSVYLLDPNTLQTADISAAIYWRAPFYSLADVKQFVEFIVMDIEPTNITKGKWRLAEVQVARASDLGVNDKTYFARTHLGNLLHAGDSVLGYMLTGTNFNNEEFDAIEASGVYASTIPDVMLVKKHYPNRRKHRNRNWKLKRMNKDEGELLPKKADQDRMNEDYEQFLRDVEEDDELRATMALYKAQQAAKVDPDAMSIAETEDGDGVPGVDMDELLDDMDELQIKE</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYK4</accession>
    <name>H1VYK4_COLHI</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007635">
        <property type="protein sequence ID" value="CCF45316.1"/>
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        <property type="protein sequence ID" value="OBR11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04036"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45316.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11740.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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    <accession>H1W1F2</accession>
    <name>H1W1F2_COLHI</name>
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        <submittedName>
            <fullName evidence="8">Alpha amylase</fullName>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008568">
        <property type="protein sequence ID" value="CCF46315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155182.1">
        <property type="nucleotide sequence ID" value="XM_018305758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1F2"/>
    <dbReference type="STRING" id="759273.H1W1F2"/>
    <dbReference type="GeneID" id="28869865"/>
    <dbReference type="KEGG" id="chig:CH63R_10784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10784"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024572_2_0_1"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="12"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF46315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="60347" checksum="61C00E68363A3F9D" modified="2012-03-21" version="1">MDEEQKPTAENHTMMQGFEWYVPADQKHWVRLEKQIPQLKRYGIDNIWIPPACKGSSKTGNGYDIYDLYDLGEFDQKGSVGTKWGTKEELLKLAHTAKSNGVGLYWDAVLNHKFAADRKEKCQAAEVDPEDRTKFVSDKYEIDAWVGYDFPGRKGKYSDMKYHWYHFSGVDYNARNEKTAIYKILGEKGDQEWAESVDDEKGNYDFLMGSDLDYDHPEVVKDVLNWGKWLANEVPLKGIRFDAVKHYSEDFLRQFITELDKDYGKGWFFVGEFWKDSLDDMSEYLARMGRRFTLFDVPLVYNFSNISRGDGADMRKVFDGTLVQKEPMNAVTLVMNHDSQPTQSLEVPIEGWFKPIAYALILLRGEGYPCVWYGDIYGVKGEQPFPPSCGGALHKITLARKLYAYGKQADYFDYPTCLGWVKYGTWDRRFGCAVVASNAGPGSKRMHVGEMHAGEVWTDVLGWNDREVTIGDDGFGEFVCSGTSVSIFVNREAEGRDKFNEELWVPMPFKRASPLTIHSDSNIYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR17</accession>
    <name>A0A1B7XR17_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EC7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14383</name>
        <name evidence="2" type="ORF">CH63R_14509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150600.1">
        <property type="nucleotide sequence ID" value="XM_018309357.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150726.1">
        <property type="nucleotide sequence ID" value="XM_018309483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR17"/>
    <dbReference type="GeneID" id="28873464"/>
    <dbReference type="GeneID" id="28873590"/>
    <dbReference type="KEGG" id="chig:CH63R_14383"/>
    <dbReference type="KEGG" id="chig:CH63R_14509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14509"/>
    <dbReference type="OrthoDB" id="4817122at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="7191" checksum="3818DF763263791C" modified="2016-11-02" version="1">MPSSNFASFPLVARHCAQPTNCGAVVQGTMCDFCCASNVKPDSIHCKSRNVACQSGGQPGGQTFNCDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRM4</accession>
    <name>A0A1B7XRM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150927.1">
        <property type="nucleotide sequence ID" value="XM_018308609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRM4"/>
    <dbReference type="GeneID" id="28872716"/>
    <dbReference type="KEGG" id="chig:CH63R_13635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13635"/>
    <dbReference type="OrthoDB" id="5404773at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601006" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="124" mass="13290" checksum="D753606FD1A64D80" modified="2016-11-02" version="1">MHTSFILNTLVTLGAATAVSASAIAPRANRKANEFSSGNCAQGTASYEHESNFNVDVTMDDTSHSVYFASGPWFYYGGKTGNGGSCTGDLLGSWANDEKNPCVNLDRRGDDGRRIKCVRWNNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRY5</accession>
    <name>A0A1B7XRY5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_13774</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151066.1">
        <property type="nucleotide sequence ID" value="XM_018308748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRY5"/>
    <dbReference type="GeneID" id="28872855"/>
    <dbReference type="KEGG" id="chig:CH63R_13774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13774"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601014" description="Probable beta-glucosidase G" evidence="18">
        <location>
            <begin position="18"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="19">
        <location>
            <begin position="666"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR02548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="757" mass="81202" checksum="0384C5CEC96CC050" modified="2016-11-02" version="1">MLLSLITTAALVGAAAPSPPVYTNRSDHFIVVPTFPTPQSAESTGEGWKAAFEKAQEAVSRLNLTQKVGLTTGFTYGLSCNGNIAPIPEIDFPGLCLADGPVSVRIADLTTVFPAGLTAAATWDRQLIYERGRGLGAEFRGKGASVHLGFAEDGTEIQAISANIDDRTMHELYLWPFANAVRSGVVSVMCGYNRVNQTYACENSKLLNGLLKGELGFQGYVVSDWYATHSGVNSVEAGMDMTMPGPMNTAATTLPGMPSYLGGNLTQAVLNGTVPESKVDDMARRVLSAYFFLHQDDDFPSIDPSTGFVFAATYAYPDEYLTLAGYDPSNPPPARDVRGNHSEIVRKVAAAGTVLLKNTNGTLPLKEPKNVAVFGNGAADVSEGLTYTGDESGPWGANVGALSVGGGSGAGRHTRLISPLFAIRNRVEEGTAGGRVQYLTDNAKIVEGDFTSIYPPPDVCLVFLKTWSREGTDRLSFENDWDSTAVVNNVARKCPNTVVVTHSGGINTMPWADNPNVTAILAAHYPGQENGHSIVDVLYGDVNPSGRLPYTIPKQPADYDFPIVNITVTLAQDPDAWQADFTEGLMIDYRHFDAKNITPQYEFGFGLGYTTFALAGDATFAPKSENVSAYPPPAARAYPGGNPALWDTIGSISATVENTGSVDGEQVVQLYVSLPRRGVPSNTPVQILRGFEKVALAPGASKLIEFPVLRRDVSFWNTTAQDWELPVGEIEFRVGFSSRDIKSKTFGTFLSFDISPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS25</accession>
    <name>A0A1B7XS25_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151079.1">
        <property type="nucleotide sequence ID" value="XM_018308761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS25"/>
    <dbReference type="GeneID" id="28872868"/>
    <dbReference type="KEGG" id="chig:CH63R_13787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13787"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="210" mass="23614" checksum="4B5DD250256CF08B" modified="2016-11-02" version="1">MITQEIISIRTVITMAGQPTACNRNLPRLIWAPNENHNRYPSPAWRYESRRVALIVPPSAERETEKEALGQDDGKGMCLRVLATQTNNSGGIRTRAQATRNSTSTNLCHIANVENISPQSLKESTSWNKLFQDQQREDLQDDLHLLVSDLSGQKTTNFAVNLDGYTLFKNLYGLIFLLNHDFSPPFPAPDCHGPRWIECRSLSANQAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS75</accession>
    <name>A0A1B7XS75_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151141.1">
        <property type="nucleotide sequence ID" value="XM_018308823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS75"/>
    <dbReference type="GeneID" id="28872930"/>
    <dbReference type="KEGG" id="chig:CH63R_13849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13849"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="37353" checksum="99A3995EAB7EAC48" modified="2016-11-02" version="1">MTNLLNPHLSRHSHLAFWGSRISLAFGHLHSVVLTLGHPHSITSAFSYFHLTVSRFWGSRIMTYTLQPSLYLTFTSRIPGQQNPFGSQPSPHHHHLGSQPCFIFSCFWGSRFTVQPRSLSTSITHFIIIFLTSTFWGSRLFGLRPSTLHHLVFLEQQIHGSTSITLNLDHSLYHHFLDFNILGQQIVWPSTIFTSSSRVSGAADTRLAASLRGITSRHHFAASLRGITSRHHPHILLNHYSPSTFWGSRLFSLGSRPSTLHRLVSLGQQIHVSRLHFAAPPTHFTQPLFSFDILGQQIHSSRDHRDFTHPPHHHHSLGFNILGQQIVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSS8</accession>
    <name>A0A1B7XSS8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_14010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151302.1">
        <property type="nucleotide sequence ID" value="XM_018308984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSS8"/>
    <dbReference type="GeneID" id="28873091"/>
    <dbReference type="KEGG" id="chig:CH63R_14010"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14010"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="57367" checksum="292E6DE3189A8688" modified="2016-11-02" version="1">MSEGHAKRSRAGSTAKALTSHHKGCANCERRRIRCDFQSPKCAKCHKKGLECPGYNRQLRWVNGVAARGYLRGRAVPVRPGPRVQDEPATSHRPSLDVSTHIPRPREAGGSMTQAVVSGPDTVPRAAGCDLLGPTTAFVDYYRQNVAGLMVWLDSDENFYRRKVVPLAESHPAIRFAIMALAAQHGTWTLPPESITVIAEDSRNRCLTLLRRRAREMTTRLMGGSELDQQEDMADAEWMLASILIMANFENARCSPQVADGHRRAARTIVNLFGDATWTAGGRELFAFLRNQLAIDNILGATTSFDPSLIRDAITPAPGSDDQLFSKYLAFLHEVTLSTSTASTDADLPAGSAEPGGPRRLTLRMVQSEFTQARGADLIAAGRMGLAGSRLSRDFVRLVEVYHNAGLLYSFRCLGCADEGSTEWDAAASGLFRHLVGFEDQAVFVQNLPWPAFIAGTACYRDRARQKVVLELFAAIHRATRFNHYLDAVDFLETFWAEDDPDWRPLARAREAAGNRILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT90</accession>
    <name>A0A1B7XT90_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_14170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151462.1">
        <property type="nucleotide sequence ID" value="XM_018309144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT90"/>
    <dbReference type="GeneID" id="28873251"/>
    <dbReference type="KEGG" id="chig:CH63R_14170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14170"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601040" evidence="2">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="35"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="474" mass="51345" checksum="F6E46AF4C55628B9" modified="2016-11-02" version="1">MTSLLVLVSLAITQLLSTLAQECRNQLKPVYRTPIAADGWTFRLVSNGFDRPRSILFDHLGAILLVDARSGIKHLRLTDDGGTCLYVAEERIVIESLDLNHGIALSPDGKTLYASTVDKVYAWSYDAIEGVVNDSNRTLVANMSNTGHTTRTLPLSNKKPGIILVSRGSAANIDQDAARQETGHSQLRAFDIGNLGENSQPFDFTIHGTMLEWGLRNSVGIAEEPVTGGIWTVENSADQLRRNGVDIHRDNPAEELNFHGYLDNSAEKRSRGVTTATQTALRCDKGGMNTGEQFTLTSLRTLNDTTCAFSHVPPRLSFQAHTAPLDIKFTPSGSEAFVTFHGSWNRDEPVGYKLSSIPFTNGMPTEPADSRTPLTDVLTNADINDCPDNYFRPVGLAWDSRQRLFMTSDATGELYVLQRTDVLASASSPAVPISTSSQGTPEVPSSPIFVGGLAMSAALALGGFGIFGFPLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTG7</accession>
    <name>A0A1B7XTG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nacht domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_14269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151561.1">
        <property type="nucleotide sequence ID" value="XM_018309243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTG7"/>
    <dbReference type="GeneID" id="28873350"/>
    <dbReference type="KEGG" id="chig:CH63R_14269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14269"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="280"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1132" mass="129397" checksum="D1E5DBA021CDA2F5" modified="2016-11-02" version="1">MGDTYDPAQHAFKSAIHEFKSNLKNEELYRQILETTSIDQVYDATDSLQKEQAKKGHLRNLSKIDVYLSRLREYAGVVEVFVQVQPDILALIWGPIKLILQWANVLKQSFDAIVNTLEEIGILLPEFTEMSRIFEDNDRVKEVLVLFFKDILDFYLITLQFFSSSRLKFVFEMLWPSRREKIKMVGDLIKRHTLLMRNKVRLEEIREAHNSRRRDLEHLQLTERVFTQQEYNSVRVHVSPRSYDEDLYRLSESICPRTGRWLFQDKFFQEWINSTASVFKILWLKGIPGSGKTFLAATIINHAKALKSKVLGHNATLFVFLSYKESHTTALSVIHSLIFQLTDDSGTLQTALCQSSRQNMRSSLEVAVGLLESLLRCAGFTFIVVDGIDEIEEVERVALLKRLLQILKSCEGCRILLSSRPESDITAILKDHTVDIEVNKRNSGSVQAYVNNRMAEWFQVKAFDPEFQRGIEGSLAKLAHTANGMFLYARVIFAIIWEIDTLEELRSLLRSPPATLNDAYGRIFDRINQSTNVLLKSKARRILGWVCCAPSPLTRREIEHALIVNSGDIEGEARVVSVLDVVRVCGPMVEVVDDYVQFVHFTAKEYILHNKTLDHITLLDATLSLTTCCITYLCQAHHNEELSREDIGENLLSGAYRLHDFAALFWFELLKQFLILNKTDKLPDDLVDGLESLYDERYDAGHQANAESQDIKAEFDIFGPKLAPLQQMLNNVSGFQMTVANSDYHLGQETRWIHLDPLTNSRISTGIYAQLDRLLCPTAYHERGCACSTIRQNYGPRVFKCGFLRCQSRRHGFKTRSERNSHERHHEQPWKCDVPGCEYSDTGFLTRKWRDYHLQSDHRPEKKATVGVLGDPDEDEIQPLLFDLVGTDNVEAVRALLPRFESLPNSVKDELYVQAAISGSSSMLDLIWPTLWERGKGINDDLSRIATFIAAIRAGNFNSSTWLVAKLRAHASSLHQWSRIYYCGRILAAVVTSESKEMYDNWKAAILSCAIDGIDNREAMRYVSDFTGSLVNVASTTCSVDLARTLLDAGAEVDFRRSSKYLTPLHCAARKSTEEAARLMEFLLHRGADPNTSSKHRKLEDEEGIRQISRWLGYSWDELVEKTMANRKATEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTM1</accession>
    <name>A0A1B7XTM1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151618.1">
        <property type="nucleotide sequence ID" value="XM_018309300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTM1"/>
    <dbReference type="GeneID" id="28873407"/>
    <dbReference type="KEGG" id="chig:CH63R_14326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14326"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="221" mass="25053" checksum="4CA6C62364DA8EBB" modified="2016-11-02" version="1">MSAAMSAHELAHLAAMGLPPPSVPTATEPAPETPVTRANALVIPVMESSKANNYLTERVKDGFRSMRAKDRKSTKDEGFATQRLRHKRIQAMQYAYHPWMDRRLPKIPLVAVSKLAGMADVAAHLAVAQAEAHAYLLRIGPRPRLEAEAKAKAKAKSKDVDEPARAWEYGYYTFKERRKHEGYAESNRLDAFEWSRVSATLRARLKAEETRIRRRYLRQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTV6</accession>
    <name>A0A1B7XTV6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151708.1">
        <property type="nucleotide sequence ID" value="XM_018307291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTV6"/>
    <dbReference type="GeneID" id="28871398"/>
    <dbReference type="KEGG" id="chig:CH63R_12317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12317"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601046" evidence="3">
        <location>
            <begin position="20"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="426"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="550" mass="60364" checksum="F86C588DEEE1624D" modified="2016-11-02" version="1">MARLSILLHAGLLIQVGLAATSPGGNRINWGPCPDFNSTEPIQCANISVPLDYTQPESNKTLQLQLLRIPALRQPSKGSILFNFGGPSVAGRPAMATSGSLFRNSTSEYHDLVTFDPRGTGNTLPISCFEDEQERTSYVLKNPKAWGSLIPPNFWAKSSDNTPARLWAYAKLYVDKCYERNKEVGGLVGTAFVARDMMQIVDALGEDGLLRYWGRITPRFLWILWHQGSGTDFVLPGGSYGTLLGQTAAAMFPERIDKMVLDGNLNPHEYYHGYDDEQWTDSDKAFSAVFQSCVANPSTCRLAQRYQNKTASQLEETIYTLINNLNDRPVPFNGTLIDYGFVKSGVMAALYSPGLWVLLDVGFDALISRDLARFTQIWAVLATTYDSIGAAVDAQVGIRCGDKIARVESLDEFLPIMEQQFGISRIFGDVQTATEMVCAQWRLPAKEQYAGDFRVKTRRPILFIGNTADAFTPLASARNASAGFEGSVVLQTNGYGHSSTGTSSCVDLVTEAYYVNGTLPENGTFCELDNPVLPGGATKKQRAKRSLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV56</accession>
    <name>A0A1B7XV56_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ploidy protein mob1 maintenance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152154.1">
        <property type="nucleotide sequence ID" value="XM_018307737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV56"/>
    <dbReference type="GeneID" id="28871844"/>
    <dbReference type="KEGG" id="chig:CH63R_12763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12763"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="283" mass="31948" checksum="9C3C848E46E2319A" modified="2016-11-02" version="1">MDRVAGLTVVRTGLLAEIPSLPPPVVPPAAPDPPRSYEGGLVSRDMTVINLSELQVPEPVLTAADDNCADDSNQKAARNQFRARTVKGANNGVALRQYAEATLGGGSLRKVVKLPEGEDENEWMAVNMVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWQDNENYKRPTKMAAPDYIEHLMAWVQRHIDDEQILPSRIGVPFPKSFPSTVRQIFKRMYRVYAHVYCHHYAVIRELGLEPHLNTSFKQYVLFVDEHKLASGKDFYGPLNDLAEKMIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVW2</accession>
    <name>A0A1B7XVW2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152401.1">
        <property type="nucleotide sequence ID" value="XM_018307984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVW2"/>
    <dbReference type="GeneID" id="28872091"/>
    <dbReference type="KEGG" id="chig:CH63R_13010"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13010"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="285" mass="29220" checksum="3F9AE2EC8DAFE93A" modified="2016-11-02" version="1">MAEAQLKDFPSLFSLKGKVAVVTGGSRGLGLHAASAFLQAGASKVFISSRKGAACQEACKALNALPNLAPGAVAIPVPADAADIKGVEHLVAEVKKHTDRVDVLFANAGATWGEAFDTHPDAAFAKVMDLNVKGVFNTIRLFTPLLEKAAGADDPARVIITASVAGLGIGTLGKQGTYGYSASKAAVIHLGRNLALELAPRHITVNSIAPGFFPSKMSNGLLEIGGGADKIGKGNPMGRLGRPEDIAGAVVYLASRAGSHVNGEVIAIDGGSLWQRGELNVPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWR5</accession>
    <name>A0A1B7XWR5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152717.1">
        <property type="nucleotide sequence ID" value="XM_018308300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWR5"/>
    <dbReference type="GeneID" id="28872407"/>
    <dbReference type="KEGG" id="chig:CH63R_13326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13326"/>
    <dbReference type="OrthoDB" id="3942074at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601145" evidence="2">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="213" mass="21206" checksum="DBEA7E40B8BD56A0" modified="2016-11-02" version="1">MARYLLPVLAFTVAVLAKTDLEGCTSFTSTVTVNPSPGYGNTYETVIWYVPDTLEICAGVDCGGGRAPPRKVPGCPAYSGTETVTASFLPTNPAAIRPTATPTATPTAFTTALGETDADKDTATTSAAIVSKRTSTVIMIVTTTLSTGQASGTKHAIGSVDPTDGASRGNGTASATTRATVTSTITTTPAAGPTARAGVAAIIGVAAAVAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYB2</accession>
    <name>A0A1B7XYB2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153285.1">
        <property type="nucleotide sequence ID" value="XM_018306444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYB2"/>
    <dbReference type="GeneID" id="28870551"/>
    <dbReference type="KEGG" id="chig:CH63R_11470"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11470"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="219" mass="23126" checksum="A5A7F0495A15FF04" modified="2016-11-02" version="1">MSSSPALPSQHVQISPAGAPPARRDPPRRRVLLAKHLDPFQRTLQAPQLAQREVDDATALAHAPRAGQDGLGAKQDPADRFQHLLLPGAEPVERRVRHHPRPPRAFAAICPGPLAAVGLEDDLPAPELGGEVAPPDEVLVAAAPAESLEVTVEGLQGGEVHSRSHSPGANVCGQGRRPRHQGWGVLVGLEEGGLANVGAHARHPGGGGCMCFWERLVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ48</accession>
    <name>A0A1B7XZ48_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153553.1">
        <property type="nucleotide sequence ID" value="XM_018306712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ48"/>
    <dbReference type="GeneID" id="28870819"/>
    <dbReference type="KEGG" id="chig:CH63R_11738"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11738"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="556" mass="60848" checksum="E89C7DEF0622C6CF" modified="2016-11-02" version="1">MPQNIPPPQTPQNQSAPLPGGQAVAYAPAQASPPPKTTPTKTTLKALPTVRDHTTDQLNPAGDEYLPREIDEFGEKKVMPNGQLLGGREYRCRTFLVPNRGDKLFMLATECARVLGYRDSYLLFNKNRSLYKIIASQPEKDDLVSQEILPFSYRSRQIAIVTARSMFRQFGSRVIVNGRRVRDDYWETKARKQGFTEADPAGEKRPGAAKAREAAAEAQNQVLLGGPHGEIVYSNTPSQFPGAPQPQIVQPGMLGAPTGTTTRMPVITLGSELSDNRPRDYSGILKGGPRQEITGPAYQDQTRPAQVGEVHTQAHHAAEYNRTLNQQREMRGDYLQGIWRRPHEQPQSTNLAQNVATSDAAVPPTRATQSPHASTSNMPQSGVVPNQSPQQMMMSAPPYSQSIHAQNPISQAPMRGMAQPPSQKNNKSTTLPAAGSAGSMPQGGQGYHYPGTGQMWPQTQQNPQQHNYSGYTTQGQQSHQQPPAPQLRHANSGVQPAMQFSGMPGMGQSYGGGQGIYPADQTPRQYMPQPNQGSPAVTQAWSNQQTPAQWWTNQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZZ5</accession>
    <name>A0A1B7XZZ5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153856.1">
        <property type="nucleotide sequence ID" value="XM_018307015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZZ5"/>
    <dbReference type="GeneID" id="28871122"/>
    <dbReference type="KEGG" id="chig:CH63R_12041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12041"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="74965" checksum="FF00A265CED72369" modified="2016-11-02" version="1">MDLNGRDQSQEDIDATLGELLSNFSSAASGDDDASWYSQCTGRVKAKWEEGNSSETNDIRSHIRNQIVVDIQGKRFDSSMTAKDIGNAWGISIGLCKEYCGRDKLNMVTSFNRLAAGSTSYLLPWLALTAQLPYETGSTETDIMSVCVGLGSPMLMTFSLMMTILNKRWIRKRFRDLAGSCEGDGFTQMRVRLKSARVIAEEARQVPTRLSQRHAWLARLVMLDANTAWWRAASESLRSTRRGATLSLYAQLSVAAIAWVLTAIGSLKTKVGDTEEALVLSSGSLWIWLVPVIIGWVLVGTQDKEDTMRVALANANKTINIRNEETGIEVVSDRKSALLTDPDTRCVNVSPATSKAAHNTKPRMNLRIFDVAGFQRQQGPVFNYARSITWLNFADRLYMAFEAATDRMKEHENLSSQPDDTRDARVKISADCGLVTDYCDHGDAARSPPAAVPDASASTSTNNDTDSSRQQLLGAEAPPGHELVEYPSLEEMSPAAMSTFWRHAAFSAAVALALQWGTTGWAIYMSYETVVKGLGCRSGSYVIYGLLASASCAAMLVSAWLSHSTMRGYQGELNTTGFLTSHGATRLRGAAAVTARLAGQFLLVGNTVWLLLISIFELIGFFDSCYCAGTQLSKGLDHGWILLFKGADYLKSDAQAAWGTGIGMGFLTIFLAVMIFYLASRQKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y037</accession>
    <name>A0A1B7Y037_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153884.1">
        <property type="nucleotide sequence ID" value="XM_018307043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y037"/>
    <dbReference type="GeneID" id="28871150"/>
    <dbReference type="KEGG" id="chig:CH63R_12069"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12069"/>
    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="468" mass="51428" checksum="C9E1F0F2AC94832B" modified="2016-11-02" version="1">MAILLAPYNPSMQLGSGFNSFTQQLCINNAVMRGPTVEANAEKTFKGQAPEITYKTSVIEKVTDITSAMDINPAFSIKYDTFDAKGKGDFINISKVKESDISFLVSITVVNEVVEDYSLTKFDHIPDVKPEHFAEVYGDSFISGFQEGGEFTAVISIKAKDRQKASIIKARWVSSLMTANFLAIFNGGKYSAATYFTKEKFIMDADGESKMDDMSLLEENETTVSVTWTGGGREFKRRMLDIAEDGWTFETIRAAALKFPDLVARTPTRTKAILTKYSALQSFQSALAAGQSFMALIPSYEKAEVYIAILQEAYIDLKIIAKNLQVLSFNVDAGTEELVESPAARRLREQGGNAHGAKGEDKNQAADSDDDLPIVTVKKDSSRATRPYEPSLAGLEVARRDVRVMLNRIVAEVDAITRKPELAVDKTRPSPCPSPSMFKELLPESRPVQDSAGAFEVSSKTAGICWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0S7</accession>
    <name>A0A1B7Y0S7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154140.1">
        <property type="nucleotide sequence ID" value="XM_018304716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0S7"/>
    <dbReference type="GeneID" id="28868823"/>
    <dbReference type="KEGG" id="chig:CH63R_09742"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09742"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="35268" checksum="7EF0922E7C068AE0" modified="2016-11-02" version="1">MSNFVKPIPKSILIFGAAAHIGRPLTEYLTREAPSIKLRLATSSPNKKKQLQDAFPNAEVVQANYSDVASLSAAVSGIEGVFVITPGGLSEHEAMTNLVTALKEANSAIHIIRLVGVFPEIPASQIPATVGPGSLAVEHPIAKRILDESGLPVTYINSGATFIDNFWIQIRPVLAKKTLIWPEHRVPFIDPRDIGEVAARLFLSDNAKHIGAFHTMNNGHDWLTYREVADILSEVLGEPIGYEGDFEAFSGFYGPVMGPQIVQYLWNFFKYEESHEVMWSLNNFVERTLGRKPTTVKGWLLEHKEKLTQGPGGNGWASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1Q7</accession>
    <name>A0A1B7Y1Q7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome subunit alpha type-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154468.1">
        <property type="nucleotide sequence ID" value="XM_018305044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1Q7"/>
    <dbReference type="GeneID" id="28869151"/>
    <dbReference type="KEGG" id="chig:CH63R_10070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10070"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="288" mass="31167" checksum="9C385AA64313CAB4" modified="2016-11-02" version="1">MADRYSFSLTTFSPSGKLVQIGTLPHRPPPLLICYDDEAGGSTYKLTISQTTNGIVLATEKKSSSPLADPSSLSKISLVTPNIGMVYSGMGPDYRILVDKARKVSHTGYKRIYNEYPPTRILVQDVARVMQEATQSGGVRPYGVSLLIAGWDEGILPEDEAETKEGEEKKPTGKTGGTLKGGPMLYQVDPSGSYFPWKATAIGKSATSAKTFLEKRYTEGLELEDAVHIALLTLKETIEGEMNGETIEIGIVGPPADHLLGIEGVEGATGPRFRKLSPQEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1T7</accession>
    <name>A0A1B7Y1T7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154465.1">
        <property type="nucleotide sequence ID" value="XM_018305041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1T7"/>
    <dbReference type="GeneID" id="28869148"/>
    <dbReference type="KEGG" id="chig:CH63R_10067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10067"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="326" mass="37194" checksum="66FD1119B890D32C" modified="2016-11-02" version="1">MAIIHDLPGVKITVQVDGQDAVEYDDPDGLENDANRMNARWRTLNYVESKDDAFFSVRYQIDNSHRWESPVHALSLTLYVDGKRVDGVVCEATRFHNYNPFFVWDHTVDGSRERSTASGYERLNKFKFSKVTTTDDAAKDRVESDSTRAKLLGTIEVFIYPIIITGPSRYIGSGHRHETQRDGFNIAEKALKGRAVSHGTSFTDGGVVSQRLSVTAEYLNDHLPIAAFSFQYRSRDALHKELIIPRSPSPEPIDGLSEAEIRRLAAERLDEINNRQRSPTVKREGRRPIIKREFVEMLDLTEESVKREWKKVKIEGNRVAIDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y306</accession>
    <name>A0A1B7Y306_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154904.1">
        <property type="nucleotide sequence ID" value="XM_018305480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y306"/>
    <dbReference type="GeneID" id="28869587"/>
    <dbReference type="KEGG" id="chig:CH63R_10506"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10506"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="237" mass="26090" checksum="08F73AED976EE677" modified="2016-11-02" version="1">MLSFSLKNTKDDSVPIIHQSLNSPNTTSLTPSNPRAPSHFQPEFHKQPSHKTKKKMPSNLALTPLSSLRVSRHLIPAHGLLPNTSIQNKPLLIYHGVFLSSSASAIEAHLRSVGVVEPQWRYTMYTATHYHSTTHEVLCVSAGRARLCFGGEANPHRVEPVVEGGDVLVVPAGVAHRLLEDLDGGRFEMVGSYPRGHDWDMCYGRQGEETKAGDIGRVAWFSRDPVYGDDGPVVKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3F1</accession>
    <name>A0A1B7Y3F1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp90-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155075.1">
        <property type="nucleotide sequence ID" value="XM_018305651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3F1"/>
    <dbReference type="GeneID" id="28869758"/>
    <dbReference type="KEGG" id="chig:CH63R_10677"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10677"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="576"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1227" mass="133972" checksum="01087B6092E86F6E" modified="2016-11-02" version="1">MSEAQREREVQRYLQSWQVAQGSSLNVALSVDSIAAPDLHGSGYRPKPSSDKALTAFAQLAVLRLNVKRAMVSLIDTTTQTILAEATRNVQLGDLDDLQDHQSDGLNKDGDQPSSTNGDLWLGAVILSRPDAVCEHSLVNTCTGLDHRGKPYTATGLIVNDCREDSRFCNRPYVLTEPGVRFYAGVPIISRTGHKIGSFAVSDERPHDGLTADEIRFMQGVAQTVMEHLEWARDRVDRFKGERIVRGLATFIEGCSTLNEDHTAPKDELPRSPSTVRPPDMALTSTRRPLPRSNSYFRNAEARDRSKESSTSRQSEPAPPFSETPPSPKKVPQPKADGLSKLFNRAAEVLRQSTLADGVALFGATATTSAAPVNRSRSGRNQSSDEEDVARPATSGSGLDSSDSDTSPASRPCKILSFSVADERARAKIEQGPALSLGILEKYFSMFPMGKTFSFTEAGIGVSSGDDSASDRETMGVDGAVPVDRSEGRRRKVKMVHEELLKKIPGAKAVVFVPLFDYGEDKLAGGCFLWTSVTGRMMNLDQDLSYLRAFSNSIMTQVGRINSQKNEAAKTTFIASMSHELRSPLHGILGSAELLQDTSTDPYQSGLISSIATCGKTLLDTLNHVLDYSKINRLGRAQMRKRARQNQNRPVAITSDSLESLSMTSVVDLAMLVEEVVDAIAAGHAFKKLAGAGPFEAPKPSISVNESNNVRSVVNFQHQGSKGLVSVLIDIDPKTPWLVKTQPGALRRIIMNLFGNALKYTSSGFVLVSLSGQARAEGSKIDALIRVADSGKGMSEEFQQTRLFLPFSQEDTFQPGTGLGLSIVKQIVDSLRGSLEVRSEQNRGTEIDVHLSFSPVSDDAARGEPDDVMRNAVEQTRGLQVVFLDAADGSKIELQPLSTPTAKLTGILTETCTEWFQMSVAREDAASPPEADIYLYSEPPSVEILEKRFRDNTQRSVSRRKAPFVIVSPNAEEAVRILQEHSKLLMEFSEIVEVIPQPCGPRKLAKVFTHCLKRAEDMRENHGAAGIPAGSLAGNEKRTHEVERVGTPLHQDARLSELEPAMSVQPLIKPLGALAVSPALNGGQPVIVEQKQHTLHILLVDDNQINLKLLVMFMKKCGFSFEQAENGQEALDKFIAASSASTAASASKRRRFDFVLMDISMPVMDGFEATKRIREYEREHKLQATTVVALTGLASSDARRDAESAGFDVFLPKPVRFAELQKLLMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3H3</accession>
    <name>A0A1B7Y3H3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WSC2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155070.1">
        <property type="nucleotide sequence ID" value="XM_018305646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3H3"/>
    <dbReference type="GeneID" id="28869753"/>
    <dbReference type="KEGG" id="chig:CH63R_10672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10672"/>
    <dbReference type="OrthoDB" id="4764360at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601296" evidence="7">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="31904" checksum="F41BEBDBCBB3D56A" modified="2016-11-02" version="1">MAPDAGVWQLRLRSLLLAATVGTQKAFAQECAYAGGWALRNDRSCPPTAPVECGTGAQPRCCPSGFKCTGDGDYCPDSTWSLWGVNGKLDNGGWCCQSGQNGTYREDLNGIALLCTPSTATSLPQSHFWGEAISTASCSTTSTTTTTASTTATATGTGADTTLVSTTNAAPTASSNPAESTVATEPETAGSGSISTGAIAGAAVGGVAGGALLAAAIFFLWRRKRRQSAAGSPESTATTVATGGGSPGWAYEEQNAKFGHGHSELAAPGPRFEMESTAHQAYELDASGQASHELDSANTSTRPTQREDAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y406</accession>
    <name>A0A1B7Y406_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_10869</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155267.1">
        <property type="nucleotide sequence ID" value="XM_018305843.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28869950"/>
    <dbReference type="KEGG" id="chig:CH63R_10869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10869"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="388"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="640"/>
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        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1711" mass="189065" checksum="B305B3E7284CBBFA" modified="2016-11-02" version="1">MMSTDAVSAPVPEPATVPAQSTTTADHDQEEPALGQIECAKPAFLHSPPDSNNAHKSEASDSELSDLDEDDVDPSANATAKQDEPPVEDDIGEVLPDHWSGTVPIFKPTMHQFKDFKLFMTKVDKFGMKSGIVKIIPPSEWKESLPRLDDLVKQIRVREPIKQDIMGSNGTYRQVNILHQRSYNLPQWRQLCDQSEHQPPARRGERRANVEKPKPRSAPRPRAEAKSTASGSKKKGRGRPRRGKAKAKGQDEDEEDDAQDDEKRPMTPVSPNPDADVEVKKEEVVDSVEDPGMDVDEDEEPRSLGRMGRMGGARPAKPKTQTVSARRKYSKREGSAMIDEKAFEDFDYQMDVSDYTPERCEELERIYWKTLTYAPPLYGADLMGTLFHESTELWNLNKLPNLLDVLGTKVPGVNTAYLYLGMWKATFAWHLEDVDLYSINYLHFGAPKQWYSISQADARRFEAAMKNIWPTDAKACDQFLRHKGFLISPSHLKQHYNITVNKCVSYPGEFVVTYPYGYHSGYNLGYNCAEAVNFALDSWLPMGKIAKRCECAQAQDSVWVDVYDIERKLRGEPTPEYEETEDEDDDEDEDEDEDDATGLPSPPDSNGVVKPARKRKRAAGDKDGKTKVKKIRLKIKTRAEPICCLCPSDIPGAEILPTDDGRKAHRMCALYLPETYIDTIDDKEIIANIANINKERLDLKCLYCRSKKGACFQCSQKKCARAYHATCAAAAGVFVEEAEVPVFGEDGTEYKEQAFEFSCRFHRTKRDRKYDGDALEDDTRIREAAAALNKGEICQLQYFKGDIFAGVVVENRSEEQTLLLDIIPNGYASSTVSNVLGLTRTSDRLEVEWKWLLLPDPSDYHLPKASARAISMPSSQKAKDQLNAKRPADETPRKDAPFVEGFTWAEFHPCNECVNPNQAKVNLSKDNQLWHYLGKTSTEAKAQYSEEPSRELHNPKSNFLDTIPKPPKPVSASTAHRRVSNLSPQQSPMFVPGPTTQIGPKSEKPYVYKPRKPVETNYAGTGSFTIQRFAPTASPAPSPMGQQLHFGSDPRHPTTGAQFAQQRSTPDSHQQHAPRISPSGQGYYQSSNAVQRASPYSTPGSQSAGGGQPAQQTWATPSQNPKPLLPHVNSYGSSQQTHRRYSVAHTPSVAMKYAFFQVHHNRSEPPPLCRVLNVTYAIPRDSKTYRTPYAPWGGFTNGYEGNLRAHLMRTSPEVFFKNRQGSVQGGTPTSNPPAGPQAPGYGGPYYNTLTNTISQGSIGMYGVKTTTPSHSSPAQQAPQDNAGRQYPASMSPSPAANGPQLMPNYHGNGWHMQQPQSTPLHPAIRPQYGAWPNQPNQPQQPAQSPSQAAQQQFSQPSSQQQTTQQPVASQSQQSQAKTQPVAKPAAPKVQYKIPEKQTPVPLPAKYLAAMGKLPSTTTTSRASSQSGAKSQGTASASGSADVTNRIAPAIDAHASRTESSALPHSPTNSNGPRAQAAPRASQTPVPVPHAPAPASNSRMPFTNQSSTVAFPRQSFQPIQSTPHHTQVCTAPSSQHLSQPMNQPRAEHHTLNPAEILAQIATQPRMNPPTPTTPSHQSMPSPVSQAAAVPPYQHHGSSWGVMQQGQQSQGQQSQGYASTPGQYSQSATHHHYQPQHQLHHPYQGQVQHQHQHQYQPPQHQHQTQPGPMQSGTPHCPPPQVAGGEVPLPEVPADSTALVERMMQNLRRAAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4C6</accession>
    <name>A0A1B7Y4C6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="28870083"/>
    <dbReference type="KEGG" id="chig:CH63R_11002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11002"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6935" checksum="9517686A4D70FB19" modified="2016-11-02" version="1">MKKRLWVIILLRESDLQQWPHQVVGSELLQEADEVLLASALMVGEDEKEEEEEEAAVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4X2</accession>
    <name>A0A1B7Y4X2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dimethylaniline monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="OBR07006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018303501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4X2"/>
    <dbReference type="GeneID" id="28867608"/>
    <dbReference type="KEGG" id="chig:CH63R_08527"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08527"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="88" mass="9589" checksum="E01E21E2DFA52041" modified="2016-11-02" version="1">MPAELRQDHGIINQNITARSDVAEKLQTGIFTLRRSSIASFTNRKLTRQGGHEWKPVEGAEGPVCRLLWDAGPCAVEAFWRGGQAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4X6</accession>
    <name>A0A1B7Y4X6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155573.1">
        <property type="nucleotide sequence ID" value="XM_018303550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4X6"/>
    <dbReference type="GeneID" id="28867657"/>
    <dbReference type="KEGG" id="chig:CH63R_08576"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08576"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="127" mass="13146" checksum="E72DF521931D3979" modified="2016-11-02" version="1">MRVETALVSTVVAFASSRTARADMTCGTSASLNTRLAWKAHIACAATPVRKTSVGRTASVGIREAGRLGAGAASIRRVEETTKCGGFKRNPLSGLGRSSPSELPWEASGPVELGGDPLPPTRVEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y535</accession>
    <name>A0A1B7Y535_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155648.1">
        <property type="nucleotide sequence ID" value="XM_018303625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y535"/>
    <dbReference type="GeneID" id="28867732"/>
    <dbReference type="KEGG" id="chig:CH63R_08651"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08651"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="500" mass="54000" checksum="04166C8DC9BE53A6" modified="2016-11-02" version="1">MHTSGPQILAAALTAAVGVNGHTLWSRQDADYQALVASLSSTAKVFYAGSDDFNNITTRWSNLEMPTVNVVVRPTTENDVVETVKFANKKGLPFLATNSAHGAITTLGKMKSGILLSLDELTGVEIAADGQTVTVAGGTKSHVLSHALWDAGKQAVTGACECVSYLGPGLGGGHGFLQGRHGLIGDQFRSMNVVLANGTLVTINEAATPDLWWAMNGAGHNFGIVTSVTSQIYDVEHPDWALELMNFSGDLVEELYEVTNNEILKNGTQPVDLINWSYWMMSPDLDAEKPIVQILLMQEGVTAVDPAYTAPFHALGPLSNSSESGVYTDLAKFVGVRTTDGPCQNTGANNPRFPIYLETYNTTAQKLAFDFFADSIVTNPALSASLVTFDDYPMQGVKAKAGDSSAYGHRAQNVLVGPLLQYMPGDAALDEEVARLGNEFRQILHQGTGRDFVPAYLNYAFGNEGPEQWYGHEEWRMTRLREVKAAYDPNGLFSFYGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y545</accession>
    <name>A0A1B7Y545_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155687.1">
        <property type="nucleotide sequence ID" value="XM_018303664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y545"/>
    <dbReference type="GeneID" id="28867771"/>
    <dbReference type="KEGG" id="chig:CH63R_08690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08690"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="415" mass="45051" checksum="3BC5DBC35FD172A8" modified="2016-11-02" version="1">MAMKGISLGLHRISRALEGVPQKWDAIHVAGTNGKGTTCTYLAALCRSFGISNGLFTSPYLVEPRDAIKINGVPVQQDIYNDVRRKILDDEQARLSQDASQEALTIFEVTTLIAFGVFGRADVQMGLVEVGLGGRLDSTNALKRKKVTVITKIGLDHQAFLGNTLPEIAKEKAGIMMAGVPCVVDGSNPPEVLEVFRQHAASVSAPLHLTTNQTGLLETLYRSELMPHQAQNMACAITAFQLAYPHLDLSVEKALPILKDITHLGRLSWLELGEKYPSRKGNPILIDGAHNPQSAETLSTYVERRLRDADKPVTWIVSVSKQDGKDAGGMLRTLLRPGDSVACVPFSKRETMPWVEPLPLDTLREMASNAGAKEIFMGEGGLEAATQWAVDTARDGPVVLTGSLYLVGDAYRILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y679</accession>
    <name>A0A1B7Y679_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156065.1">
        <property type="nucleotide sequence ID" value="XM_018304042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y679"/>
    <dbReference type="GeneID" id="28868149"/>
    <dbReference type="KEGG" id="chig:CH63R_09068"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09068"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="208" mass="23037" checksum="8A56B2500326B803" modified="2016-11-02" version="1">MIRLLLLLLLLLLLLLLPLLLLLPLLKEVHDLFSRPALLVKRNEVIKNGLPLYRDLTAPQGWNIKQRCQDRLVIIFATAEARHTLCRETIRPVAAQRNQSPSPRDVKVSECLHLTFSGFRVTHLLLAPACEALRAPPKKTQATANHRATSPSAWQDIALAYSRGCGGLASATSALLLVEGFPLSPRPGCYALVSSEQSHEHRILSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7H9</accession>
    <name>A0A1B7Y7H9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156519.1">
        <property type="nucleotide sequence ID" value="XM_018304496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7H9"/>
    <dbReference type="GeneID" id="28868603"/>
    <dbReference type="KEGG" id="chig:CH63R_09522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09522"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="390" mass="42065" checksum="BAE5A1957A078153" modified="2016-11-02" version="1">MSASKPILISGAGLSSLLLAQSLRQSNIPFRIFERDASFAFRAQGYRLRLSAEGLDAIESVLDPRKWQHFWDKCGKTGGSGFTELDATTAEQKDHAVREELSSRDNKIVGIARGTMRELFAEGCEEHIEWSKSVTGYELTEEGVRALFADGTKSVEGSMLVGGEGIRSKVAKQVSGGRLKVYDTGARGIHGQAPTTAFKHLGEGVFRLRDGTRPDGTVIVMTNVRSSDMDDPNIKFGWTLGGQPGVINAPNDDLAIVGKKAADIAKSLTKDWHPHLKPLFDEMDESEAAFWKITCSTPWGVPEWPNEPRVTVIGDAAHSMTPAGGLGANTAVQDAALLGRLLREAGGYKPGVTAAYEKEMRVYGSSAVHKSYSIAVGVFGIQVDENSPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y819</accession>
    <name>A0A1B7Y819_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_09599</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156596.1">
        <property type="nucleotide sequence ID" value="XM_018304573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28868680"/>
    <dbReference type="KEGG" id="chig:CH63R_09599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09599"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="942"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1183"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1212"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="306"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="678"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="951"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="901"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR08078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1547" mass="168511" checksum="8DBA0B2107328257" modified="2016-11-02" version="1">MNNVSNVCHDELFGPAVATESCRGGFDFTVLFEESVLSIPLSAGFLLIAPIQVARIFKAVSAAIATSINVQTRSYFSVTLVVTPFCNHQQVHVINIGWKVSTLVYAGLNLALLVLWASGHGFTTRATLASSVLSLCAALALAVLSQVQHGKSPRPSFTITGYLTISLPLNGARVRTAWLLASDKHLMPAILTAALAVQVLILVLETKNKRKILAGAYHSFSREATSGLLSRGLFWWLRHLLSDGSRRILAVEDLESINEKLRSSKLSSELQVRWMNKNHNRHKHALALATLSAWRLELAKIALPRLFLVALSLAQPFLIHQIVETISAPVSQQTWNQGHGLIGAVALVYTGIPVISTSFLPPGLLLIRCVCHKIATGFYQHLSFRLMAMVRGGLISLIYAKIVQSPSTQVGDSAAMTLIGTDVERICETWHLVVAESWASVIQLAFAVWFLQMQIGPVCITPVIVALVATAMSVRAAGFVTARQKVWLEAIQARINFTAHTLGSMTSVKMLGLSNKFESLIQGMRVAELDLSKRFRRLSSFNVCLVNLPSLFSQFFTFATFAIAAKIQGNSFVTVSQAVTALSILSILMEPLGKLLVVIPQAYAALGCFQRIQDFLASESWDDKRLPECPLGTTNLESHNKPDTIQTPLDHNRVEMIQRPQSTPKEPLPRTIFNSDHVVIHNATVGWRGSSHVVKDMSLRISQNHHLTVILGPVGCGKSTILKAILGEATIFNGSVWISSKELAYCDQSPWVSNGSVRENIVSGTDFDAAWYNTVVHACALQVDLLQLSDGDATNVGSKGVSLSGGQKQRLTLARALYARKPIAVLDDVLSGLDAATHDIVTTRVFGADGLIRKLGMAAILATHSVSLCAIADQTIILDDQGQIIQRSSSENMASLAPQLAGDVGSSASSGNSPPPKFSAGETLGLSTRRDDNRQVGDLSIYLYYFSSLGWLSFALFGFFVASNVAFGTLQYAWITLWAQSSDGSQASRISYWLGLYALFGVFTAAGLISAVYYMYVVIVPKSAQSLHLTVLQAVIRAPMSFLAKTDTGVLVNRYFMTFAFSQDMQLVDMTLPGALVNASFQLAACFAVAALAIVAVPYFAAVLPFVACALFFLQRFYLRTSRQLRLLDLEAKAPLYSHVLESLQGIATIRAYGWTSNHVAKNLALLDRAQKPYYLLLCIQRWLTLVLGLTVAGLAILLTALGVTLRSRLDAGFLGVALVSMMNLGQSLAALITFWTLLETSLGAISRVKTFSEDTPTEKPREIVDTRILAGWPSQGSVVIENWSAHYNGYIYLTFYFLEFCTRLKHHPVLRNIDISIQAGEKVAICGRTGSGKSSLLLSLLGMVDESTGRIVLDNVDLALVPKDVTRQKLTCLTQDPFLFGGSVRLNADPHGEATDIDIISALQKVGLWDIFRSKESTETSHPLEFSILDMNMEEDFLSQGQRKLFCLGRALLRKSPVLVLDEPSSGVDASTKSYIEAIVESEFATSTVIMATHSLAGVRRFDKVAVLDGGVLLEYGEPDELLGRIDGAFAKLYAVQRGRPETASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y880</accession>
    <name>A0A1B7Y880_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156750.1">
        <property type="nucleotide sequence ID" value="XM_018301972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y880"/>
    <dbReference type="GeneID" id="28866079"/>
    <dbReference type="KEGG" id="chig:CH63R_06997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06997"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="318" mass="33032" checksum="7A072349C7CD29F1" modified="2016-11-02" version="1">MTTSGRQKRIFMTGASGYTGSVVTELAIADGYIIHALSRTEASDGKLRDLGAVPIRGDLCSLDTLRRESAQADAVIHLATAYVFGGEPYETFRPMDTAAVDAIADALAGTDKPLVVTSGTLCVAADPTGAETTEASPAEPNPINTRIKTELHSLSHAAKGVRVTSIRLAPYVYGRGGSGVAQFLGIAAKTGGVVCVGGGRNRTTVVHVDDAARLYLLAAEKGRAGEIYNASAATDVTSRRLSEAMAAAVGVPLRDISAEDAKAQLGATVAFFLAAENRASGEKARRELGWTPRGPGILEEIGSSKGSYGELAKALRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8Y2</accession>
    <name>A0A1B7Y8Y2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157000.1">
        <property type="nucleotide sequence ID" value="XM_018302222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8Y2"/>
    <dbReference type="GeneID" id="28866329"/>
    <dbReference type="KEGG" id="chig:CH63R_07247"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07247"/>
    <dbReference type="OrthoDB" id="2956246at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="440" mass="45445" checksum="E4E79BDC36137472" modified="2016-11-02" version="1">MPFPLLSKEPIPGLSLSAAGLVALADLHTVANRTALKGTSSWLDALVLAPGLHYQQAADGVAGDSGGGGGGGGVAAATFGTGGTGGNGSAAGIFGTQALPGGRRRDVRVTNPGLLLFLSRLGVREEETEKKKRGRRRRGSKQAEGGEAEEAFGIRAVCGAGCGAGAGEKKKKIITLDVGTLGDRRRRRGRVFAHDAGWEFERGSHLLYLASPALTLAALTIVVLLGDWWALASILALITSRLLNIYIIKQRTSPPPAYPPPFPAEAAAAAATTTRTTPSSSPPPKLAEYIIPLAPTLKIRLRGPELALAALTTDAPMRPKTTAQNYLEAAAKLAVYTVAVLGGNVSQAGNLVLLVLLLGSAGLLGLSNGFVRGVGASGGRVVARVRDGEVAVAVADGTARGGREGEGEDEERAVDSADWDVQVGRVIRDPYPFEEGVEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y996</accession>
    <name>A0A1B7Y996_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_07312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157065.1">
        <property type="nucleotide sequence ID" value="XM_018302287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y996"/>
    <dbReference type="GeneID" id="28866394"/>
    <dbReference type="KEGG" id="chig:CH63R_07312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07312"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601440" description="Acyl-protein thioesterase 1" evidence="11">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="210"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="358" mass="38148" checksum="FECE51E170C12EC6" modified="2016-11-02" version="1">MLTSRAHASRLLFFFFILANLASLTAASHPADQRHEHHQGPLLNPGEAIASGSDQQHPPLAAVADAELLLPFAGPLAPAAPAAPEAMSSSLARTAPLVFPAAGKHTATVIFAHGLGDTGHGWASAVENWRRRQRLDEVKFVLPHAPQIPITCNWGMRMPGWFDIVSRNTIFDRHRRQASSSSPASSSSSSSSPLTVPQKRLDGTVESLRESEDEPGIRASSEYFQSLVQAEVDAGIPAERIVLGGFSQGGAMAIFSGLTGPHRIGGIVGLSCWLPLSNKFAGIVAAGSPSQDTPVWLGHGDADPLVRPELGELSAEALKKLGFKVSRTLYPGMPHAACPEELDDVEAFLRERLPPTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9D1</accession>
    <name>A0A1B7Y9D1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157209.1">
        <property type="nucleotide sequence ID" value="XM_018302431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9D1"/>
    <dbReference type="GeneID" id="28866538"/>
    <dbReference type="KEGG" id="chig:CH63R_07456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07456"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="126" mass="14290" checksum="74B6072312BBEC36" modified="2016-11-02" version="1">MLLLLDDDEDRPRFLKCWDLRSSAADFWDDKTHPTARTAKGKEGKADGTRNTVFVDGLCFGLLHWHQRPGCRAMTSPTQAPRGWLQTSRPTNTTRSRASIILAEGWANRHIIAYAYNPEPLVLPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9L5</accession>
    <name>A0A1B7Y9L5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157192.1">
        <property type="nucleotide sequence ID" value="XM_018302414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9L5"/>
    <dbReference type="GeneID" id="28866521"/>
    <dbReference type="KEGG" id="chig:CH63R_07439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07439"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1155" mass="124015" checksum="5DB1307A9A27777E" modified="2016-11-02" version="1">MNNYYPYGYSPYPGQAPAQQQQEPYFPIMPPFPPQVASYPPHTNTFEARPQPPDSYDQNQTMIPGLGYNHLQGFGWSQPQPQPQPQQQQQQQQQQPAAAQIPFQQSWQPPREGPNLISAAQYYQPNNVPKSKAPMGSETLPPTVPRGPAKPTTDDAEEGELSDGELEDVYEPQETVRSGRDTRATTNATAENGDNSVGRAAASWYGDLRDGGMRVPTAADIDERERTRSYSPHLSPNEVHSRTATNDQHNDSPRTQAFGSKATQSSTALAGQQSGKKALEDARQRAQSAVLSLWPLGVRHQDYLDEGIDKNVVKELFNELKLDSGTSSQFAIPGLSVTAQLPGLSQSYTQSSSQPNSASTSTATLKPTNKASPTVAKSAGEERKDRIARLLAAKNAKSAPSALNNGAPAAGASDKVLIQQQKQDALQKSREARAQKAAERKGSLQASQSKETSPASSIRRPPSATNITSAAPSTAQQAQVASSQQSTSQVAPVSTIPGLFMSTPQSAPINNQRKRPVAADFVSNSNVNKRPFGPTRQDEPFVIDVSDVSDDEDVEMEIGSPTDEPASIQRTDTPSRKTASFRDFPPIREGIPQRQLSSPAPSNVATPQSGILGAQPKQAHLEVMDKQIEAMKRKIALAEARAKLKAVMSNQAGGQKSKGQTPDVAVDSDSGKPAIRRVQSMDASSASDQLNGQASPVIAEPSGSMRLPKLSDKRVEGDSTRAQKLRVVSTNLPLIENRLQAKKSKLRLLQSQMSRLEKEIEQEIAEKQKLSEEMEQLNQDSDESEEPQNQLKSNSVDPVVTQTSTGSQSNVQSPSAVATAPKDQSAGMITSASADVAAAARPFRSPSTDHGEKVPTPTREVAVTGKAATSPLEAPTSTDNQVTTTAVAEVPVGHVIAGDDEESQPATSDDASDVVMGESDSSSSLEQDRESSSDAYEPPENVAPAVATKSPSIGLAVADSTVSLANSDTDLQQPSSRASPVPQQISVGVNESTPEQGVDAAPPVAQSTIEPSSGDGFTPYESPLQYFRAYRYHPKFAETVPGGLRSLTYSNRIDPNLPICPDELAGRDCPRGADCIYQHFESMKLPDDQILLQLGGTTLEGPERAQFNDGLRKLLQEMRSQNIKDFSSIAQGIVDYRNRFTSDPSKMLPLGNASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA23</accession>
    <name>A0A1B7YA23_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157298.1">
        <property type="nucleotide sequence ID" value="XM_018302520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA23"/>
    <dbReference type="GeneID" id="28866627"/>
    <dbReference type="KEGG" id="chig:CH63R_07545"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07545"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="40835" checksum="59B68ADDDCFCF87A" modified="2016-11-02" version="1">MDQKSPSKENRNLVDGVGREKRGGSCCWRWFLQGERGLSRWGRESGRREDEKRTRNTMGTVGQASHTVNGSLLWSTHHPKERCEIRRTHTEGEDWRTTRRAEEGHDESDSLTRPRADAGVLGSWPIITLELPKSRLIGGGCPFGQWLVAAVGWLDPCKLHHCVALLPKDDGSDVQHRRAHVTAHRAFLELPVQIFPAFSHLTCGKRGVCLQRWGLPQRLEERDNSHLTLEPPRLTSSHCQEGVRDITRHVTKLGGTSATPGYLKRVVTTQPLPADVPEIEEARVGLPSRTEDTPRTPEHHTDGEVDFDAELQAPSWHDPDCGLAFHRIRWHDITAADAQFPSSWLLPCRTLSLAATVPTTLVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAE7</accession>
    <name>A0A1B7YAE7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157559.1">
        <property type="nucleotide sequence ID" value="XM_018302781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAE7"/>
    <dbReference type="GeneID" id="28866888"/>
    <dbReference type="KEGG" id="chig:CH63R_07807"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07807"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="6">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="887" mass="99908" checksum="94F4736C78A80516" modified="2016-11-02" version="1">MDQIFRKVERGIDALFGDERHAHTHMGHQCHEHHPADHAENRYQSFAPQTTGNAKWYVDGCSYFWAVSEAIEQARESIYILDWWLSPELYLRRPPSQNERYRIDNLLKAAAERGVKVNIIVYKEVEAALTLPPSHTDFIIKHTRTYLESLHPNIGVFRHPDHVPTGYDFQAELRQNFSNMNLNTFSLSKASGDAIKAIYGTASDGVTLFWAHHEKLCLIDGKIAFMGGLDMCFGRWDTNSHPIADAHPGNLDAVIFPGQDYNNARVYDFADVDNWEQNKLDRTKSSRMGWSDVSLCLNGPIVQHLADHFVDRWNFIYGEKYGKKNPGKYQALGGANGNSEAGRIAENQTESSGFFGGGGGGGGGGGHLFGDLSERINRGVSRLMVSDDHDDGRLSRVDHGDRAANIQLTRSCTKWSSGHATEHSIANAYIEAITKARHFVYMENQASFHTHILHFFITATSKEQHPVTNKIGRAMVDRIIRADRDGEDFKIIVAMPAVPAFAGDLKADDALGTRAIMEFQYNSISRGGYSILETLRSEGGIEDPGRYIRFYNLRNYDRINTSSTMAAAEQRSGVRYEDARREHDDVVGAGYGDRGEGTGARWGERNSQYERYQEAASRVSDQTWDSVSACYMDSGPDLHSVPWHGEPEAEMDAFVSEELYIHSKLLIADDSLVICGSANLNDRSQLGSHDSEIAVIIEDPTPVESEMAGRPFTASKFATSLRRQIFRKHLGLLPDQPCDRPNDNWTSVDRGPNTYDWNSPADRLVRDPMSRGFWDLWERTARTNTEVFSKVFHNVPNDHVRTWKDYDEFFSKHFIIPGAKEQGNTSGKVEYGHVVREEFPGGVGEVKDWLNRVRGNLVEMPLDFLVDVDDIAKEGLSLNSFTDEIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBK3</accession>
    <name>A0A1B7YBK3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157973.1">
        <property type="nucleotide sequence ID" value="XM_018303195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBK3"/>
    <dbReference type="GeneID" id="28867302"/>
    <dbReference type="KEGG" id="chig:CH63R_08221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08221"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="817" mass="90688" checksum="FB743AE33FF1BE96" modified="2016-11-02" version="1">MPPQTRSGGRARVAPPPDRVYKSTKPAKQATFPHRRTEVRTYSARKPTARISDHQQRTLTQMFETTRSSPVRFDLSDDEEDPVPRKKRRKTAGDSPTPSSSFHTQTLTQMSRRSLEKSSGDEEEDDVWQFQPSDDEIEKHAPVLPSAKDKENQVPGKKALSRTPSVIPQTPTNKRVILEIPSSQGSPLTPMLARYSPAPKRSPLKNKSTNTMSPLPKLTGSVKRPRTLTVQDSYATTGSQASSQLTSPSKMPLQPAKNVRFITPHPTASLVPMEEDEEEETEGEEQEGRDVSPSPRRPARSPLREIADSEDELDDLEILDEEAEGYDAVGEETQVQMDQLLASSEEKQASKEASPAEEDDSDKENVTPAASDEDDEEATVVLSKPFAFPKLARLDSGASGRRETVEVITSSPEPTHNSGSSVIGEASGETNDESVSQTPTQGQKTPKSKGKASVETPKTPHTQGLESQRLPQDVVDGMGPQGDRTDIFISIRPEHMENIVAGRKNYEFRNYKIPHTVSRMWLYVTQPVGELRYMACFSDAKTPGEIDEDGIGNAEFNQKKGSKFAYRLDRLYELNDPLSLQYMMDRDYLHGPPQKYNYVLPAVVGHLMANLRCSVFGDDEDEDEEDRAETEAKPEPETGRKGSLPAASGPSQDRTMSQELAEQIRSDIERSTQHHSSDADLLVPSSQTPTRSRRKFGTELHLTKPTLPPTPFSRPPNPTPRRAVRPSQATTVSHASSSPSQMRFESVPRPTHADSSLPIFVDDEDDSPIRLPSGTFQLDSSQLLSKSQMLPESLLLENRGDEDEEEIVFDSEQDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCS7</accession>
    <name>A0A1B7YCS7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158165.1">
        <property type="nucleotide sequence ID" value="XM_018303387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCS7"/>
    <dbReference type="GeneID" id="28867494"/>
    <dbReference type="KEGG" id="chig:CH63R_08413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08413"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="492" mass="54409" checksum="24E9DA62BBB55DD9" modified="2016-11-02" version="1">METKPNDIAPKVVIVGGSIAGLALGLMLQRIGVDFVILEAYREIAPQAGASIALLPNGIRVLDQLGCWEDIYAAAEKGTNKFTIRYNDMSPILVLDDLEDKVTQRLGYGLIFLDRRMVIEVLYNHILDKSKVITSQKVVSVESYAEGVKVLTNEGSEFTGDMVLGCDGVHSTVRKEIAKLEGASQENQLKATYCCVWGIATDVPHVPRGTLVNTYGNDYSYLFADGPGNRVYCALLMRMKETYAGDAIPKFTSDDEAEMAKLHEDDLILPGVKFGDVHRRMIARICTPLAEVVFKKWHSGRLMLVGDSAHKFEPLSGQGGNNAIETAAAFTNALNRALKENPNRRLGSGQISEVFKSTQLVREPRVSRLVKASHDQQNIEASQASIQTAISSQFIKILSEEMQLAQFGDVTLDAISLDMLPIPNRPRRIAWHDERHRQPDSPTELLTSRIWLIAVADITTGISPYKHSPAQVPSTSSLGRLWLFSIRQLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCY0</accession>
    <name>A0A1B7YCY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158379.1">
        <property type="nucleotide sequence ID" value="XM_018300529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCY0"/>
    <dbReference type="GeneID" id="28864636"/>
    <dbReference type="KEGG" id="chig:CH63R_05554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05554"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="84" mass="9035" checksum="043632F9F871D62A" modified="2016-11-02" version="1">MEKEPQITDLGESTVRSYSRIVSDRERRNPIFCVPSAAHGKLVRVEDDKQDAAAAAAAAAVSPVTVLLARQVPFSPDGPHRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCY9</accession>
    <name>A0A1B7YCY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158424.1">
        <property type="nucleotide sequence ID" value="XM_018300574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCY9"/>
    <dbReference type="GeneID" id="28864681"/>
    <dbReference type="KEGG" id="chig:CH63R_05599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05599"/>
    <dbReference type="OrthoDB" id="5426765at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="469" mass="52829" checksum="3B48B4567202C735" modified="2016-11-02" version="1">MEAVSLAASILAVVDLWRVLKQSITKFYPKSADLKSISYRTNRSILLVQLWLSEAGLDERIKGQTWDEYRLFIHDEIQELHRFLESSKLKMPIRLMSAGLPPERIMIQLAERIEKLAYFSRDVAQILASKGIQQHLDTILEMLGKSTRESAETWETAQSIKKHTEAGASFDNEFAAALTKMEEEHPEWSSNERQRKIDEVRAIIRLNMRNHDQFDRDRMTFPFCIVVQNSDPLETRVKLDTGSRPNWISAQLLSRAAISFQPEDDLGQFIGAGKDALPFEPLGVTSVTWFSENQARTRTTEFLVHNGELPVNVLLGSEWVIEDIAQERFPEPVLPVVRHILNSDELNKLETDAREDGASNDLLIRLQNQQKKAKREENRLLKAASRAMTPRSAVSLFGSVTPTRATRRGSLASVAPPFVISPQTLTLTPETTVSTGVGYPEVGESSTAASSQTSGLELREEVDVEAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDU2</accession>
    <name>A0A1B7YDU2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158712.1">
        <property type="nucleotide sequence ID" value="XM_018300862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDU2"/>
    <dbReference type="GeneID" id="28864969"/>
    <dbReference type="KEGG" id="chig:CH63R_05887"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05887"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="697"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="791" mass="88533" checksum="9CEFD844F416E977" modified="2016-11-02" version="1">MEQSPEAQQQHSPTDGQPANRGSDALPRPRPLACTPCRRRKMRPQNANLLQLREVWLGMRLARRPSLFRTPSETVSHPCPVFRLALNLTLTLAPPILFTEEMELYEDVVSRLAQMEKLVEELQTTKPDQGATPPPPQLQHANSHDAAASLSPLATTTSSSNPHSPLSRRKASSASPSSANHDSYPSPPSATSSTGARLYYTGAPDDSTVFAAGNEPEPSSKERKRDRQRNALQPKALALHHQPYLAHEDLNHPLPPNHVIMDCVNEFFVTMNAGIRTFQEHEVRAALRSYFQGQPPADPGWRMAVNVMIAHTLRKRNGMRNKEEYQKYIYNALGMVPNIILRTPSPMTIGALLSTVLYFSFTSENHIAMTLMGLTVQLLLMAGYHRLEPDLVHANPQNLDPVNHLHRRRLFWQAYIIDHDLMLRIGKPPLISDDFLLDLPEEHPADGYSMYYYPGDVTLNFFLQQVRLAQIQGRIASSLYHRTGVPPAELEAEIRRLDGELQEWRESIPPMIRADNVDALLDGDYYRMVSLTTLHFTYFQLVVAIHSAAFRLPMLEDQEGTEAADIGPSLALCVSASRAAISLLNYHQIEHPYTPYLLYQIAWSVDILFVNILQNKTNPRARRDLDLIRTVISFFEKYDPGHQTVVSYQIIKVIADVAASVLANTPTLPPHMLPVSRGPSAVVQQPQTPIQNIPLDTLSPPIGGPGSARSGSVNSGTGDVLGSMTSLSMSDTQQQQRQTQQQGFMDISAGLTQPNEGQFFTGFMDMAADWRLPMDYQPELWQYDTDTRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE93</accession>
    <name>A0A1B7YE93_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nad binding rossmann fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_06099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158924.1">
        <property type="nucleotide sequence ID" value="XM_018301074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE93"/>
    <dbReference type="GeneID" id="28865181"/>
    <dbReference type="KEGG" id="chig:CH63R_06099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06099"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="179"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="397" mass="43257" checksum="80C7AF83FE2549D5" modified="2016-11-02" version="1">MSGEKLNVAVAGLGRMGLRHARHFATLTPKANLIAVSSPVQAELDAAVAEFGPLKTYLDYDEMLRQEPTLQAVIVASATTVHAEQAIKAIERGLHVLCEKPLSTSVDIVCSDPPSLSSTYPIFYLCFLGTMTIASSAPPTDCEGKQQSQSVVTAYEKSLIKNPSQKVICGFSRRFDASYRDAHQRVARGDIGAPSVFRSQTCDKLDPSGFFVDYAEFSGGIFVDCSIHDIDLALWFFGEDSVVKSVAAVGITAVQEGLRKHNDRDNAVAVVEFYGGKIAQLFCSRMMAAGQEDTTEIFGTRGKVAVNTQPQLNLVNLYEPTGIRREIPPDYYGRFREAFIAEANEFTACCLNDTEPPMKLTGAVSAVKIGCALQESLITGKKIEFDERGERIESARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEB1</accession>
    <name>A0A1B7YEB1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158889.1">
        <property type="nucleotide sequence ID" value="XM_018301039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEB1"/>
    <dbReference type="GeneID" id="28865146"/>
    <dbReference type="KEGG" id="chig:CH63R_06064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06064"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601573" description="Secreted protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="7433" checksum="BD3764E2E3182170" modified="2016-11-02" version="1">MSAVLSCGSPSSSCLCAVPVALLLADAAVAAAAAALGKPNACRLAEMDGRRLDASPDPALTVVCGDGYTSGRPPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEB6</accession>
    <name>A0A1B7YEB6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158741.1">
        <property type="nucleotide sequence ID" value="XM_018300891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEB6"/>
    <dbReference type="GeneID" id="28864998"/>
    <dbReference type="KEGG" id="chig:CH63R_05916"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05916"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6878" checksum="43043FB44E292B35" modified="2016-11-02" version="1">MYRRFPVLTPYEDDPNITGPFLGRIEQGRWSRGSWLVRPPDNALFLSLPSLSNTGRREGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEM4</accession>
    <name>A0A1B7YEM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159118.1">
        <property type="nucleotide sequence ID" value="XM_018301268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEM4"/>
    <dbReference type="GeneID" id="28865375"/>
    <dbReference type="KEGG" id="chig:CH63R_06293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06293"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="147" mass="16913" checksum="BB81BD1F1AEF5181" modified="2016-11-02" version="1">MSRRPRQKPRRRVRFCQGDHDGAVDDDDEAEEGPPRPLPNHDYKAIYKWWNDEYRLVAVCITGAIVLGIIFGRFDKQVVPQLKGGIDFDVVIVAMFTCVRVAMSGIVESSISQAAWIWVSEARQRRTNNMRARLEDFKIYDEASRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHI6</accession>
    <name>A0A1B7YHI6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159972.1">
        <property type="nucleotide sequence ID" value="XM_018298726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHI6"/>
    <dbReference type="GeneID" id="28862833"/>
    <dbReference type="KEGG" id="chig:CH63R_03751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03751"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="71" mass="8516" checksum="D1382984116324AD" modified="2016-11-02" version="1">MKQGQIQSFRSMDQLEAGSQKRLSEEDILFLTLKDWRLFVELQDILQPLYKQSIRTQGWQKMCLTEPSRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHT1</accession>
    <name>A0A1B7YHT1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159951.1">
        <property type="nucleotide sequence ID" value="XM_018298705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHT1"/>
    <dbReference type="GeneID" id="28862812"/>
    <dbReference type="KEGG" id="chig:CH63R_03730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03730"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="301" mass="31930" checksum="2833B92C76C45CBC" modified="2016-11-02" version="1">MGRRDASPARSDDDWGKLPDEEDVDIDNDLALDPEASSRGREEASTSLLASHSVYNSNKARPSRRSFTTSYPVLAIIVLSCLLLGALASTALTALVSHIRNTSSSSNSSTAHRNDNTLASPSHDNQTAATYLLPAPCGTSPSQARAAGCLFDLVSFNWLPPQCHDAELAASFEADLRSAGHLAWYEDPRGARPIPRARVATGEVSGVYVSLGYHLRHCTAMWRRMHRALMQGGGGLGRVDGYIWSYHHTRHCEEMLLAAALDSGSSGGGGGGGGGGGGGEMAVYSTEVRIKYPDCGVVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI73</accession>
    <name>A0A1B7YI73_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160177.1">
        <property type="nucleotide sequence ID" value="XM_018298931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI73"/>
    <dbReference type="GeneID" id="28863038"/>
    <dbReference type="KEGG" id="chig:CH63R_03956"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03956"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="289" mass="31987" checksum="557C36A2E06D1887" modified="2016-11-02" version="1">MPQQQKFALVTGCGRGGIGEALVTEYTRRGVHAIATVLPHEASDHLSDAGITFFPLDVTNEQSIIDLKAALQKLTSGNLDILVNCAGIAYTMTAIDTDVGAVQRMFDINLFGPMRMVHHLHEMIIQAKGTIVNIGSIGGIIPFMYGSSYNASKAGLHHWGNTLRVEMAPLGVKVITVISGEVSTNILKNDAHRKLPEGSYYSVLSENFQRHVLRTPEGATDRFDYATNVVAQSLKSSPPSWFWYGSFTGVTRFLDMFCWRTVWDTLMWNMFSLDKLKQAHSTIAKKLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIF5</accession>
    <name>A0A1B7YIF5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc c2h2 type domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_03894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160115.1">
        <property type="nucleotide sequence ID" value="XM_018298869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIF5"/>
    <dbReference type="GeneID" id="28862976"/>
    <dbReference type="KEGG" id="chig:CH63R_03894"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03894"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="819" mass="91466" checksum="6ACDE353BB7BE526" modified="2016-11-02" version="1">MAVLGPTTNAPAAKEHLVALFATIPDDPKEIFVCDVPGCDQKFVRADLLSRHQKRHSSTYIPRNRAPSFSTSVASAAVSSPTSAGLSRSTYPQHSSSGGPHDAAILLTPGSDATPTPTTAATNPSLTQQAARLGQPSTWPSIDDMAADMMRPKPNFYVREQVSLPEAPPLMPSYTSVSFQPDEALSRENFAMWLFDSQASFSEFNGVANIPFLEGGLESTFNNNIHYDYESLTSRSQLDPTPPRQVEVSDELISEHRRQEVLRWLQVFRQKQPKYEPRIVSLVQESGGDLPALNLDMMRDCLQEYWKNISPRLPIVHQPTFSSNRCPILLLMVMIALGAASLSSRDSTGNLEQYGGFADVVISSIRWEILTADEASPPVGLYVAQSLLLLEFYEKMFSSRRMHERAHIYHSATLTLLRRGSPLIGRAGSESPPEEAAPTVNDGSSSDSRTWWIRWAESESMHRVVFAAFMMDIIHALTFGHSADMAPHEIRLPLPCDDGLWTAATPDVFRQLDSNYRMYGIKQVSFLDGLKSALHGQEVKTHTFGRMIIMSGLLSVGWHLSHRESHTKWLDLRTPSAESRDGWKKILLRAFDEWKESFDNAVGANDTPEVPGQPSTSNGPIHSAAVLYHLAHISLRVDIVDCQVYAGAKYLVGRKVSTRDYANAVSRMRTWSNAPSTRHAVLHAFKLLYHVLVDQRGPKRRTSSFDSLPEPVSVFYSCRTEPDPHRPWVMFYAALTIWSFVQALGMPSKNAPPGRYSEIARYLAHFAALDELTDEAARDLNDRLPELLDLLGTSLQQSHSEIMREASQRLKRCCDMMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIS9</accession>
    <name>A0A1B7YIS9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160311.1">
        <property type="nucleotide sequence ID" value="XM_018299065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIS9"/>
    <dbReference type="GeneID" id="28863172"/>
    <dbReference type="KEGG" id="chig:CH63R_04090"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04090"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="175" mass="19126" checksum="6AB59F84F7C69DE5" modified="2016-11-02" version="1">MVPPDKGPMLTTCGQHHKATSRSGTASCIRTFQENVKAGASPEPDAPVRSGRTRGNPRQQITKVSVERRGLDDRTRVWHMSRAGVASHIQAHRTTFPRRGAFVAPSLVIASGKAGRITVTKKGVSGWHVRSLGMADARRTLCAQRRARSRQNGPSTPPVPSDIRKEARVRTPQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ52</accession>
    <name>A0A1B7YJ52_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_04210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160431.1">
        <property type="nucleotide sequence ID" value="XM_018299185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ52"/>
    <dbReference type="GeneID" id="28863292"/>
    <dbReference type="KEGG" id="chig:CH63R_04210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04210"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="545"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="798"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="891" mass="101443" checksum="DBDD6B3F70738B7B" modified="2016-11-02" version="1">MAFAAKLGALTDELVEVITSTPDKKISQERFNLLRESSLRSLRYHSFLRTNQFDVESQLVGLEERFRVHHREGLADAFRDRLDAFSRFRTKWHPDILHFILELADRPTQKTRLSDLQLLKESEEDKQPPLRWEDIAKEDGWHEDAEIWRSIDYSDNSGDEYGDPQAEISSESDETSLSTLDTSLGREPEDFEISSSDEVALKEVFDSQAWRAETNKTASTRQHKVPITEFQATREALFMLQGLPTTLFQKDGVPDPAYQISSVAWDTYKALVTCFAESGRQLFQLRSFSKRPQTAPLFQVFRDNVIASLQSFDKSISSVQERLVVARRDTVVSMAAILEELRPQLEPLMSLSEIVRQLYDPANGGAFRFLELIYDEIAIAQLAGRDTTYEFLGRIFFNCFQVYLRPIRLWMLEGQLMPGDKVFFVSESSTQVPLRQVWTEQFKLRRTSDGVLHAPSFLQPSVGKVFTAGKSIVVLRHLGKFESLRELWDEQEPPLTFDTVCPLGLELAPFPELFTSSFNLWMQSKYHATSETLKQALFDSCGLEANIEALQQLYLMADGAAADEFCKGLFARLDALRPDWHDRYSLSGLAQEAFSLRVDTTRLFVTVRLEGQKKPVVAARDLIRTALPEVLLQYRLPWPVQLVVTEDTITQYQAVFTLLMQIRRAMSLIQRTRILDELAYRRDIWGSRALYYLLRSKLMWFCNCIQTYLATLVLAPYTENLRQSLRQAYDVDAMIGLHATFMRQVVDAACLGRKLDPIRGGILDILDLAARLEDAQSASVAEEAEEAQELSRLSIMSSPMKASPRRRKPAVYAEDSDDDRAGSFGGRAKRGAINAGKGYHQCLREIKTDFERHLRFICGGLRGVARASGDEAAVKWDLLAEMLEVGVKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJH6</accession>
    <name>A0A1B7YJH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160672.1">
        <property type="nucleotide sequence ID" value="XM_018299426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJH6"/>
    <dbReference type="GeneID" id="28863533"/>
    <dbReference type="KEGG" id="chig:CH63R_04451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04451"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="183" mass="19650" checksum="70B33F81C7E849DC" modified="2016-11-02" version="1">MVWTLVEPGAAIVASSLVTVRPLLRAWRLSGFISTDRTPGMSGAISGGMRSGTARTAPRSAPRHDPYGVDDGDTDLELNDMAKDKPMPRPTPQIGYPSPFAQAGLERTRGQFDSDFVKPPNQRRGSLAKSEMYVIEGDKASDIWRGDRIGSPSASSVDLEGLDGLDAQSQHSGRVGLGGRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJT2</accession>
    <name>A0A1B7YJT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160782.1">
        <property type="nucleotide sequence ID" value="XM_018299536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJT2"/>
    <dbReference type="GeneID" id="28863643"/>
    <dbReference type="KEGG" id="chig:CH63R_04561"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04561"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="302" mass="34753" checksum="38F0308DE29C1276" modified="2016-11-02" version="1">MPARLPPRISRSLSSPIRPPGSFCSHNTKYFTSNRAPEPTRPALLLRPSFQYPPSRLYSSISSMDPIKPQANGVLTPKPVLFFDIDNCLYPRSSRVQDHMAQLIDEYFAKHLSLSWEDAVKLHKEYYTNYGLAIEGLVRHHQIDPLEYNSKVDDALPLEDILKPNPKLRQLLEDVDKSKCTMWLLTNAYVNHAKRVLKLLGIEDLFDGLTFCDYGQQPLVCKPAKEMYLRAMREAGVEKMEDCYFVDDSYLNCQKAQGYGWNVAHLVEEDLPVPQTPASAHQIRHLRELRDVFPQFFKSKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL63</accession>
    <name>A0A1B7YL63_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_05075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161296.1">
        <property type="nucleotide sequence ID" value="XM_018300050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL63"/>
    <dbReference type="GeneID" id="28864157"/>
    <dbReference type="KEGG" id="chig:CH63R_05075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05075"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="597" mass="66804" checksum="19A960DAECD5C392" modified="2016-11-02" version="1">MGGSLYRWTRVRTLVLTFIIIVFLVYILDAIWLHPRTETAMLERHMNAANNAATPPPPPVSPKSSFDWSAVKFKYPPQTPLTPVPAGGKGSSSLPRVQHRFPSESASAARLREARRREVRQLFRRCWASYREFAWMKDALNPISATAKDQFSGWAATLVDSLDTLWIMGLRAEFDEAVAAVASIDFGASSSERVNTFETNIRYLGGLMAAYDLSRRPVLLAKAVELGDMLYGAFNTEHRMPVDFINFNDAKTGNGLVVEGSVVSASPGTLSLEMTRLSQLTGDPKYYDAAAKVMDLFHDGQQKTKLPGMWPMFVSMSNRDVTSGSTFTIAGCADSLYEYLPKMLALLDGHEPKYRDMTENFLRAANESLFFRPMLPGGENVLISGNVDVDGAGNKVLDPESEHLACFIGGAYALAGRLLGREEWVAVGARLTLGCYYAYQAMPTGMMPERFNMVACARRDDCPWDEALWEAGKKLRPEYKEHLPKGFTTAKDARYILRPEAIESVFVLYRVTGERGFQEAAWEMWKAVSNGTLVELGNAAVLDVTRKQDPLPKEDYMESFWLAETLKYFYLVFSPPDLISLDDYVLNTEAHPFRRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMK2</accession>
    <name>A0A1B7YMK2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dual specificity phosphatase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161788.1">
        <property type="nucleotide sequence ID" value="XM_018296972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMK2"/>
    <dbReference type="GeneID" id="28861079"/>
    <dbReference type="KEGG" id="chig:CH63R_01997"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01997"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="540"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="644" mass="72690" checksum="15807EA589E83461" modified="2016-11-02" version="1">MADQQQAAARPSSANPHDPEATDPALLKDNSEIRDYKTDRFTYSGIRTFYKRHLQADQLPKPPLPLLVFIHGLGGSVAQFHPLLTSLVHISSCLAIDLPGCGRSEFTEQAWDAYTPEALRELLELIIDEYRQKEPGRSVVLIGHSMGTIMCARLASHSVHNKTKLRKYVVGLVAVCPLAGPPAEEKTKIFRTLLWIPGWLFDLWRAYDRWGGPQSASVSRFVGPEADLELRKLQDRFNNQSRTPVWRRMAWGSLPRYENGVAKGGIPGKDVWAGVDVPVYLIAGAEDKLTPPSEVDKIRECLSGKASPLMETGSDDDWHETTVEAVTSSNTSKDAEDYGPESIDDIRDEDFHRDRDRRPIDDAENALEDPSTPQESPANVPPQPRHPTKVVKSIIMPRPANHALLFNPATVRVLAGLISDFLATHVTGRFSLGWQLQYLSREGKWDVKNLAKWKGVVPVSHPIGPKGKPAVFRAMKTLREADDTHCPTEFVKNWGGIIKDVIDISHDKPVYDPRSMEKGGVRYHKYATVSKIPPKDDEVAHFILLVDKLREQQKTRAEQEKWTEVDGQTQVIGVHCHYGFNRTGYFIVCYLVERCGMTVGEAIETFKAARPNGIRHYHFRDRLHMRYSGLKLEEDQLQEERQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN51</accession>
    <name>A0A1B7YN51_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161845.1">
        <property type="nucleotide sequence ID" value="XM_018297029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN51"/>
    <dbReference type="GeneID" id="28861136"/>
    <dbReference type="KEGG" id="chig:CH63R_02054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02054"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="616" mass="68289" checksum="266496EC261BB2DA" modified="2016-11-02" version="1">MQEISGTSALPSYSRPPRRSVRSREGCLTCKRRKVKCDESRPRCSHCERLNLECKWRPQSSITAAHSMLAAAGPSGPGHSPAVPSHATDASVSPAASVFQPMQAVDEIFDYASFMWDAGDAWQQVNPEPGPQMSLDGQVLRTHYGSQPLGGRQAPLMSSPPNLSFPNRTAMDGLPDPSPIPDAGSQSEQVMALNVPTEDDRLMDYFSRVVVPPILAEVETQKKWLAIRQVVVEMAGACQMVKWAVLAFSNLMLSRRESTWLASPEDHYQKAVSEVAACGDESSPVTEGHSSRREHLLATLFFLSYVDILRGQIKAADSFLKRAYGLFQQGEKSSFAAIEKQFLQWMRLLDARAVSAGGQGLLLSKDDELLLVEASPASFDGGVADSAREDLADGDIEDVLFQVLYQPGIVFFQKVQSFMGRISKIDPWHRSRGTVEDETEVMNIGAAIAADLRTLYEQRPPLMDYAVAGKLTEPHVSPHLAFVITRAFRTYLANYHASKVHLHRVAYKSFPLTKEADDALGQIRRLARLLVDSLDADNSLPVNMLWPLLMLGSEEQDPQERIWIKTQILRMERVAGNAKITAQVLEEVQARQDAEKVRVDIRSVMHAIFNSCFAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN66</accession>
    <name>A0A1B7YN66_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf647 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161997.1">
        <property type="nucleotide sequence ID" value="XM_018297181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN66"/>
    <dbReference type="GeneID" id="28861288"/>
    <dbReference type="KEGG" id="chig:CH63R_02206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02206"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="6">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="12887" checksum="22AD2001E6AD168E" modified="2016-11-02" version="1">MPTSSTQVLLERPRMASRSASLAIAEYDKAGNLKAKYVESASRIGPSRVDVLLPFKRKKPWLRLLEIFLPDGYPHSVTEDYAAYQIYDSVQAFAGSIAGMISSRAVWEGKSIGHDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ31</accession>
    <name>A0A1B7YQ31_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Steroid monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162658.1">
        <property type="nucleotide sequence ID" value="XM_018297842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ31"/>
    <dbReference type="GeneID" id="28861949"/>
    <dbReference type="KEGG" id="chig:CH63R_02867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02867"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="65132" checksum="283476A4B9DDB9C1" modified="2016-11-02" version="1">MGSLPAPPAKTGYQILEKASRSGRKLRVVCLGGGASALNLAHEIDTCRTLDLELVCYEKNPSIGGTWYENRYPGCGCDIPSVNYQFSWAPSPNWSKFYSSAPEILQYFKDVAEKYDLNKYMRLNHTVTGAFWDEEEQKWHVRVQRQDGTTFEDKADVFVNASGVLNKWKWPAIKGRETFKGTMMHSANWDNTVDLKGKRVGVIGSGSSAVQIVPSIQPIVGTMSCFIRSSSWVVGGFGQRFAGKNGGNFEYTEEQHEILRNDPKKYLAYRKKIESELNSRFRFILNGSKEQAEAKAFAEKDMRSKLAGRPDLQDLIIPKDFAVGCRRPTPGNGYLEALCEDNVTVVSSSIQEMTPKGIKTADGKEHEFDIIICATGFDVSWRPHYPTIGRNGVSLSEYWRDVPNTYLSLAVANMPNYVIFNGPFGPYGHGSFLPITETVARYVMQMLRKMSEEEIASFCPKQAAVDDFAEHRRRFLPRTAWTSPCRSWFKQGTVDGEPMMWPGSRIQFFETVATPRWEDYELRYTTANRFGYWGNGFAQRETDGRDLSWYLGLLDGVDEQPALPDEDFEAFIMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ32</accession>
    <name>A0A1B7YQ32_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162673.1">
        <property type="nucleotide sequence ID" value="XM_018297857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ32"/>
    <dbReference type="GeneID" id="28861964"/>
    <dbReference type="KEGG" id="chig:CH63R_02882"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02882"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="72" mass="7817" checksum="3CE914266C8D3C42" modified="2016-11-02" version="1">MFDDTTRPAGHVGTVTLLSFPECLTLQLHAERPPKDGLTKNLAASGFARSDSYNMNTELDVRVPTLGWNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQD6</accession>
    <name>A0A1B7YQD6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162774.1">
        <property type="nucleotide sequence ID" value="XM_018297958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQD6"/>
    <dbReference type="GeneID" id="28862065"/>
    <dbReference type="KEGG" id="chig:CH63R_02983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02983"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="349" mass="40227" checksum="260DB9590C77589E" modified="2016-11-02" version="1">MDFAALMSKELDKSKEATPASSSSSSKYLKRADVEAKRREEYLAEQARIEAEREARAASKRKREEDEAAEKKVREEKRQKLAEESRRRREEKEAEEERVRRKRLGLPELVKASSEDVAEVEDGMEDVPDGELAGRLRALGEPATLFGEGHVARLRRYRRLTTVVTKGPIPTTLQLVEEKDMKVDGAVPKDKEGRRWLFRQLASYFTMVLTEYERAMEQERRDTTASKTAYSAMVQSRENLKPLFRKFEKYDLDDDLLAPIIEIVKAAQERRYVDANDGYLRLSIGKAAWPIGVTMVGIHERSAREKLHNGERGHVMGDEVTRKYLQSIKRLLTFAQVRWPPTDVRQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR75</accession>
    <name>A0A1B7YR75_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163040.1">
        <property type="nucleotide sequence ID" value="XM_018298224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR75"/>
    <dbReference type="GeneID" id="28862331"/>
    <dbReference type="KEGG" id="chig:CH63R_03249"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03249"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="379"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="747" mass="82994" checksum="E7E1DE0B4CA8A272" modified="2016-11-02" version="1">MGLVQQANAELDVDEPVAAHPTLNNVDFGLQIGVEEILGDVDPDVSLEFLKKADAHAGKPPPTRVPRESLVSTHNSYVEQQQQSEQQNAPRMVKKVVLALSYPPSVKPVSDLSPMRLDELLVENHHEDRYLVLKTIAPPYMGAGTITIVEDEHGNTDKLVLYNQGSSTILQAVPEGSVILLKEPYYKFSGDDDFMLCVDHPSDAILLRHGPDDSLIPDGFKQTSQSEVAAEWKNAGDRAFISKNLPLAAANYSRALDLSSEDDTAFRVDVLLKRASINITVKRFDDALSDSLASRRGGPTDWKAYFVAGKAAYELTEFQASKQYFEAALEQKPEAVNIQKEYERCLARLEEERGHYDLAAMTVNVTPKNISIDRASFLSRTEVRDSPHHGRGLFATQDIKAGEMIFAEKATSVPNEFNPEHNSAAAYAQLVELCADNPTIHRKVLDLYGGSYKRSGHEGIIVDGRPVVDVFLLESIRRKNCFSGAQVSAQAANPDWDMWKQGMSRGLWVHSAYANHACLPNANRSFIGDMLIVTATVDIPAGAEITHIYLPPKAAYLLRMPQFRSSWGFVCSCALCAGEAKSPAEQHKRRVAALAEIEAVIRKKRPTRFQPDATIRQIERLTSRFSALHEAEVYDDLGLPRLMLVWPTMWLVEACHTRKQWAKVVRWAGEVFRNFGFVEPVRGGRLWMYRDTQAVTTFEVIKALKLAAEAHAALGSGVLARDCLDAARVGLTTMVGYVTDETFEAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR80</accession>
    <name>A0A1B7YR80_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163064.1">
        <property type="nucleotide sequence ID" value="XM_018298248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR80"/>
    <dbReference type="GeneID" id="28862355"/>
    <dbReference type="KEGG" id="chig:CH63R_03273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03273"/>
    <dbReference type="OrthoDB" id="4828213at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="41072" checksum="794F1F884FB07977" modified="2016-11-02" version="1">MVSESRGRKGAATRIKATDVPTIEPFAIRFQSSYFNPANNKHQLNPESSTLPANMKFTAAISFLFAAAVSAQTCSGSELQVCVGNRIKFCNLAKNNVFDLFQTSRQQPKAVILFRHCAQTSFQWHLFFNCTGFPLVSDSTPLEEEEHLDEFKAGQYYPAIIGDVYDEKYQVLGKLDFGEHRDHIYVASKSYTVDGGNLEEFQTYEALGKGNRSHPGYPHNPMWDSWKDVVRWNPAGLFNAELLKAGIAKLFLALNYLHSEDIKAENIMLELMDVTVLEAFARSELEDPSPRKFVDGAPIYKSRQFGHPKKFGDVVLGDFGAAVRGDRKRNHDAQPNVYRSPEVMLKTEWSYPIDVWNVGVMARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSQ8</accession>
    <name>A0A1B7YSQ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-ketoacyl synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163596.1">
        <property type="nucleotide sequence ID" value="XM_018295234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSQ8"/>
    <dbReference type="GeneID" id="28859341"/>
    <dbReference type="KEGG" id="chig:CH63R_00259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00259"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="111" mass="12051" checksum="ECB8A94ED5C208C4" modified="2016-11-02" version="1">MSDTKSNTTALDHKSVSEDEEGGRASEEGLQGTPVPIDEDEIAARMNNLDPPFLALFAEAVGSGRRTPGSRPVDITDISDLNVITGIPEFSAWHKDTVKFYNDPTTRDSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTP0</accession>
    <name>A0A1B7YTP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163932.1">
        <property type="nucleotide sequence ID" value="XM_018295570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTP0"/>
    <dbReference type="GeneID" id="28859677"/>
    <dbReference type="KEGG" id="chig:CH63R_00595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00595"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="692"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128784" checksum="AC13C269803724AA" modified="2016-11-02" version="1">MVFTYLQRREGLLVAAPQGNRPPERRSPLSITFLGGAGRADAGGLLVHDFIESSKSIGLQQLQLSPSIIFPSACLSSQSRNLIRCRPSPRRLLHGEHCQLAFWSSFRFLPSRAKIYPKLRAKVPSQRLRDIDGALHYARKFLLGPPKPTVTARHPLRIAEATPTLLLQSSSYAGRLVRLATAVIDSKVRRIRAPCSVAISQLHPQLIDTPDYLAPVTSRASQELGKKQLSLRRHLRHWCATPVLLAPCPFGEILVEAHYVCIGLSIAPASCRVFQAAYRHAVVIAQFAGYISYPLLGTPTATLPDLGSRWYCYHWTSSQVVFDAYLAFSSSIAVVMTPTPPSTTPSSGSGRSPEEQFRVLANASGRLKCDRGHPCSNCVKREGGDASSCSYATPSTRKKNQSQGSSSPDDMQNRIDRLEGLVLSLMHGGAVVDPSTSAVATAAATSAPTGKSNTDSTPKSGKADPDDETRMRDDEDDDSDPDGELATSLGVLKVDTEKGKSMYVGQEHWHTILKDISEVKAYFSNHKKDLEKSYEKVMMSKPASAREGPTFLLGATPASEVELRAELPPKSTILVLCSRYFNSMDNAVNIIHAPTFQQQLRAHWQDPSKTPIMWLGLLYSILCLAMLSYHKVGDEPPEWKGRALDLASEYRLRTVQCLIAADYTRPVEYTVETMILYVFGEYSSRWDADLGIYLIVSLLIRVAFRMGYHRDAKWFPTITPFQAEMRRRTWALVRMADVFFSHQVGLPSMIYGHDCDTQLPNNIFDEEFGLDTKVLPPSRPKTEPTPIAYMIAKSRLSTEMGEILQATNRVGRQLPYDEILRFDARLREINDEIPPHLKVSSLEGSHDPVTLIIARFNINVLYNKIICLLHKKYVPRARQNPRYAYSRRTAVEAALETLRHLITLDRESQPTGRLRSLKWFVNSIATKDFLLSAMLVALDLHFDRVAETSNERRRSETAIFWTPEQRLEMTRSLELTKDIWAGLADGSVEAYKASKILEIMLQKIKSPNADAETSKGGDGGGSLPSFDASPEMEPEHNAAMTLGMLSGGMTPNTAAAIESSLQASNNFGGGMDFGVSLPMTGTGMTPNFQGDFGMNNAGSPFSMFNNLEAGADFPANFDWNAFETYTQNANWAPDTGFQQIYPGQSSPETDASGMPFGSANGNMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUF5</accession>
    <name>A0A1B7YUF5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164188.1">
        <property type="nucleotide sequence ID" value="XM_018295826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUF5"/>
    <dbReference type="GeneID" id="28859933"/>
    <dbReference type="KEGG" id="chig:CH63R_00851"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00851"/>
    <dbReference type="OrthoDB" id="4848745at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="404" mass="44015" checksum="CAA1EE1017387A56" modified="2016-11-02" version="1">MIVDFGSYDMNDVRSPLDRLPSILRRRSFFGDTPDPLLSTGEVEKGKQKGPDGKLATTTEKDDGDLRVRKDSVMTGVEESTSGSSSVSVSSVSSCKRTVVTVRKRVLDVDEEGESSRSAEKGIPDSNDEDNDGGKDDVEDDAAEILSSTAVSQPAEKPSTATPRRSRFVEDLDDVRVETVSRTPAELCQQLCLLEAARDAAREAASAALYFPPVIAAQQESQAARDDDANDGRSSHEWRHYDGGCSQKKGQRRRVQALARAMVKLAKTPVCWRKEDKGKNRAVCDICGEDICLDLRGWARDSGRAQEARDAGDESVAAEVAELLGQLYDRDEAESRRRCGVCGQNVDEDLGWERDGGGDAREPKGDDGAMFGSSGEEGVTAGSVAKAVIITEMPEAWWTRRFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV72</accession>
    <name>A0A1B7YV72_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_01125</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
            <location evidence="11">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164462.1">
        <property type="nucleotide sequence ID" value="XM_018296100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV72"/>
    <dbReference type="GeneID" id="28860207"/>
    <dbReference type="KEGG" id="chig:CH63R_01125"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01125"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1159" mass="129766" checksum="6AC1DD33D15016FC" modified="2016-11-02" version="1">MKMNGPLGPEVEVFANALDDCLAPQGTVEEKQARILNLVNTYYDYSNERLSQLRKQARQASVGDTEMDLDDDAEAGSTASLEEIQEWEQERQTWDLVRRLIPLRYSTPKSKSQRTTSATKKNKEGNDLWGAFLANDELAVERRTILEWLQQSASSGPDLNDLVRELQQNADRGDIIAHGWIHTRSAIKLQKGVIGYARPLDVQFPEVARSLVNSDKAPLVAELDPDSVTRQSRKLEPQDEYFERAIWVGCFQLLRRGSSLEAIREWCLERTEVWRAVSMSALPLATDHGDTSLVEDPATLALWRRMCFAAARQGGVDDIERAVYGVLSGDIPSVQKVCKTWDDFMFMHYNALVRTQLDTFVLGQCPPEVSASLRSSFPAFDAVQFHGDATTLEQRLIHKLETSPHTSKEALEPVKALQAAIISKELERHFYEQGVAITLKANSKESSILMPDDFCRDVSVATEKFADFESSGRLRLAVHALIIFGTLDKLVDSPPNSATMSTSSDRREIQENTITLYISLLRLSGLEELIPLYCSRILNTRALQVLSTNLLPITDNEARLLQLSLIRKAGLDVLQFVHYQPASLFRSLGPEAGKTRRFQIVDAGPPSLKYGRSIRTDFFGEDPDTIESIDERLIRSVEWLLLVDEAWPHVFRVGVDIYKYFLKTLRLNAARSFASRVPFSTIMAHRVEFAEQDANDTWWTEDAEFWAGQIEASGAKSLSPSQLGMEARAFRDLECLVKALDTMETIASLTELSKEDPSVKRDFWTKVGNEVKSAKEHVRPLLKQWLRGQGSWLQAQSSRANADYIPIEDEDLEALRDMYLPETLLAYVSTLHFAGTTLTRDNFLECMELAATVAEKDSDVADCFMKAARMKELVESFAACSKALAIASGEKKAAGSSSKKLREMGWSRDLCDAMDTPPPVLPPKPGSHETSRIGTPITSNSPWPGAGAGLDANGAGVSRVHPAHQPAGLEFARPEPVPDPGDQWLPKLLQDKPKQDLADIATNPELLNALTHAPSTIHPSLSSSHKALQTALTDNLELASRLIELETRLAHQRSATQAQLLSTHALERQWRQKQSDMDHALAPFSPTSMYQRLGQGVHEQASVCHVLEESFIEGEGDGAYASERETLDWIKRYRDAKVLYNLRQERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV79</accession>
    <name>A0A1B7YV79_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01042</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164379.1">
        <property type="nucleotide sequence ID" value="XM_018296017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV79"/>
    <dbReference type="GeneID" id="28860124"/>
    <dbReference type="KEGG" id="chig:CH63R_01042"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01042"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601970" evidence="6">
        <location>
            <begin position="29"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="572" mass="63326" checksum="504A992A5C4BA724" modified="2016-11-02" version="1">MAPPPWRGALITSAAVTVFLALRQPVLSRCNLVCTFAGAYVLQMVAWGIFIVLLFPQYLSSLRSIPGPKDDHWLMGQYPRIIREPTGVPMMEWVNTIPHEGIIRYRGLFNQERLLITSPKALAEVLVTRNYDFHKPSAVRSSIGRILGVGVLLAEGDEHKFQRKNLMPAFAFRHVKDLYPRFWSKACEGVQAITDAVHADAAKGPPKGLTETEKAGMGPNVAVLEIGNWASRTTLDIIGMAGMGRDFGAIRDPSNPLAQTYQQVFKPSRQAQILAVLGMFLPGPLVHHLPFSRNGDIAKAANTIRATCRELIREKQDKLRHKKLTDVDILSVALESGCFTEDNLVDQMMTFLAAGHETTASAMMWAIYCLCLHPDVQSRLRREVRDRLPAPGTPGDITALDIDHMPYLNAVCNEVLRYYSPVPMTLREAVVDTVIDGHKVPKGTRIMLCPWAINKDTALWGPDAGRFDPERWLTRSDGSGGDNNAESKKTAASGGATSNYAFMTFLHGPRSCIGQGFAKAEFACILASWIGRFEFSLRNKEEYDEKNLSIKGGVTARPSKGLHVYVKVVDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWK0</accession>
    <name>A0A1B7YWK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_01590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164927.1">
        <property type="nucleotide sequence ID" value="XM_018296565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWK0"/>
    <dbReference type="GeneID" id="28860672"/>
    <dbReference type="KEGG" id="chig:CH63R_01590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01590"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="253"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="753" mass="82454" checksum="BDD2167103ADCE68" modified="2016-11-02" version="1">MEAVESPNATSESGTLSPAHFNQSRKRKLSGSTDRPTREYGLMRDTGKHDTARFVGSGSGIHFIRGVYVRLARKSALRTTATSSNSQSSNINDLVPGEDDQLQREASSRDGDEQNIWHDHELVPETERQDVNPSFEQLVEWSRSYFEAWHPTLPFLSAPDVLGLFEEVSAAGVASLGHLERSIVKSILSISLADSRQRAAFAQPLPASLVFRTVEEAMSASQFALYQPASVQATQAALAIQLFLVSMLRLNSASRLGGLIVRMAFHLGLHRCPSRYPFFTKEEAHMRRRVFWCIYCTERFLCQALGLPLDIRDDDVDVCYPGEERHGGGGGGGEEDNRLQLLTYLVKHARIRGLILELRNKSIHSRDDTADRASYVQAELAKWSNEIHDAVEDEQVQDENAPQPPISSGHRVFLLLLKYESMISLNRPMMTSDPSSPAYSAGLQNCIFAAKSIFISLKRYHSQNRIPAEPTSARLLEPMLQPAFTWAVWISAFILIYAAFERQLPLASALKHVESGKEILRHIASRDTSWPEYCLSAIDELTAAVRELSAPPGSLRRQPSTSNPAAPPNHLRPDMGQPARPSSSSHRPKPSHPRTRFSPSVAASTGRPDDHGLGGPPDGTTMWPPPQNQADGFSGPDDQSSGRWPTQASPASGTSAPAAGWTAGTPGAQPGFQAAAHQDSPGFDATQPFSISLAATSFPSAGVNATETAPGEGQESMVWYDQLFANSFGAIDYPFLAAAQFDPSVDPTWSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVQ2</accession>
    <name>H1UVQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04511</name>
        <name evidence="3" type="ORF">CH63R_01841</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000312">
        <property type="protein sequence ID" value="CCF32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161398.1">
        <property type="nucleotide sequence ID" value="XM_018300152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVR8"/>
    <dbReference type="STRING" id="759273.H1UVR8"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05177"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF32069.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="33900" checksum="42D53728C9C731DE" modified="2012-03-21" version="1">MSNFCSKSVVFEPESDIPDLAGKVIVITGANAGLGRQCVLEFSRHNPAQIWLAARNLDKATAAADEIRQHVPNAPIRLLELDLTSFESVKRAAQQLLAQADRLDILMLNAGIMATPPGLTKEGYEVQFGTNHMGHALFAKLLLPLLDRTAKSNPDSDVRVISLSSHGHTYAAKGGLKYDTLKTDADALGSYGRYTQSKLANVLWARHMAKEYPQFTVASVHPGVVSTNLVAGTTGSPKALQYLMGFANRWLVNSVEKGAKNQLWVSVSKDVETGQYYEPVGVGGQASKEGQDDVLAKGLWDWTEKELRSHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW24</accession>
    <name>H1UW24_COLHI</name>
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            <fullName evidence="10">Integral membrane protein</fullName>
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        <name evidence="10" type="ORF">CH63R_03348</name>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000346">
        <property type="protein sequence ID" value="CCF32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163139.1">
        <property type="nucleotide sequence ID" value="XM_018298323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW24"/>
    <dbReference type="GeneID" id="28862430"/>
    <dbReference type="KEGG" id="chig:CH63R_03348"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03348"/>
    <dbReference type="eggNOG" id="ENOG502RAKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_0_1"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="40587" checksum="B4D9873CCE03A18A" modified="2012-03-21" version="1">MAWTASNLSVLVHSTTWTMFFVASVFLGLRVYSRVRNSGVGLKADDWVLIAGWVFLMLASANASWLMSIFLLRGNLTKITLARTHHNLQSVALGLTKTSFGITLVRLMPGGWEAKLIWGLIITMNLQFAVHIIATWQAICGAPDQAHIGGDRCWGLDQSVTFTIFSALYSATCDLILALLPWKMIFNLQMKRSERISIAVALSMGVLAGVTGIMKAVQGRMLIDVRSPDYLYNQAIYWIWSMAEPNVTIISASIPVLRGFVRSVRKRSESSPGAGAYVKTGDTSGRFYNRSTITAARAEPSDQDAASDSSILARSPDPSASGGGITWTTEVTVKHEPRPETGQDGGVLLGSKGPGTVAAIEMGPIGHPGKPASRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYH5</accession>
    <name>H1UYH5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05292</name>
        <name evidence="3" type="ORF">CH63R_13947</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000615">
        <property type="protein sequence ID" value="CCF33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151239.1">
        <property type="nucleotide sequence ID" value="XM_018308921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYH5"/>
    <dbReference type="STRING" id="759273.H1UYH5"/>
    <dbReference type="GeneID" id="28873028"/>
    <dbReference type="KEGG" id="chig:CH63R_13947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13947"/>
    <dbReference type="eggNOG" id="ENOG502RZBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_0_1_1"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="208" mass="22173" checksum="F6F37876BD171890" modified="2012-03-21" version="1">MSFSNADTGNKTADPYKAANLDNDVSVKEKVETFVKFAEKSKFGMMTTRDAKSGALVSRAMALAATENGGIDLLFHTNTESHKTDEIDSDPHINIAFINSSGDWASVSGVSSVVTDRSLVKKHYTPTLKAWLGDLGDGTHDGSENDPRIGVIRVKTTSITYAVSNATIVGKVVQLAEGVVTGNAAQVNKLREVSSQEVEQYRSAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZX4</accession>
    <name>H1UZX4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_05694</name>
        <name evidence="15" type="ORF">CH63R_04911</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_DEAD"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="SPB4-like_CTE"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="DEXDc"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
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            <end position="382"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V108</accession>
    <name>H1V108_COLHI</name>
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        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_06006</name>
        <name evidence="11" type="ORF">CH63R_08875</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
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                <person name="Sukno S.A."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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            <strain evidence="13">IMI 349063</strain>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="640" mass="71367" checksum="76E6AF7BE2F15565" modified="2012-03-21" version="1">MYGQRRKYMSKRQRPCDFCRSRKAACRIDQAPPCRLCLLHGRECTFVEAAAPRKRLLPSEGIRDLDSSQSSVKTPMSMITTASQAQVPPVLTDEHPSDDAVMDFVDGINFETTQSEFEAMFRSPRALSSTPATAWTSNTPRQLRSRDEDNYPPGANPQLLGLSGDMDPLLLRHYRFDEGGMFGFKELAVHSVQSSPLPCHFLVSQQSIFSRRRDECGLERPDDETLSRQLQDIVPAAVGRRLVSLCMDFVQPLFPIFSTAEPPDPATAPTYLLAAIYAISLPFAVHDDKLSVDVAYDKPPYPALSRIVDSALSFELHSPSVPVVQTLLLLILRPSADPLVADTAYRRDALGRLVSCATTLGLHLDPSEWPMTDGRKAHRRRLSFTVYAVDQWIASSHGTPPSTHRDNWLVTNVKPGDFVDSGLGSHDESRLVDFATITEILGSALSSLYSLRAVHELYKSRDAIPAVSQPLLQALISIPNLNQTESSMSRLAILYTQLVIRRAELRPSLAQHSPHSPREDDFELSARRNIKTCTRALTDVIQDLNPDTDGVFWPSWTQLVFSSVCFTLMTMAVSSPDAEEASAWIADLQSTRRGLRLKVASFPFLRLGLLRIDALFWRGITNVLDLRPHVEEAFRAADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1V6</accession>
    <name>H1V1V6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_06252</name>
        <name evidence="13" type="ORF">CH63R_00509</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001056">
        <property type="protein sequence ID" value="CCF34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163846.1">
        <property type="nucleotide sequence ID" value="XM_018295484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1V6"/>
    <dbReference type="STRING" id="759273.H1V1V6"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="GeneID" id="28859591"/>
    <dbReference type="KEGG" id="chig:CH63R_00509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00509"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_1_1"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="286" mass="31426" checksum="0A4353368892EA8F" modified="2012-03-21" version="1">MDSLVAKYSRPAFEQHNTFRDDEQEDLELMGGAPPLSLKFAMPPVAHPSSWLRAATDDRSNPDCPIKIAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIEINSVLLGTMAGGAADCQYWLAWLGMQCRLHELRHKRRISVAAASKILANLVYSYKGMGLSMGTMCAGVTKEEGPALYYVDSDGTRLPGNLFCVGSGQTFAYGVLDAEYRYDLTDQEALDLGSRSILAATHRDAYSGGFINLYHVKEEGWVKHGFNDTNPIFWKTKLEKGEFTNVTADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V383</accession>
    <name>H1V383_COLHI</name>
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        <submittedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00182</name>
        <name evidence="7" type="ORF">CH63R_00353</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001235">
        <property type="protein sequence ID" value="CCF34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163690.1">
        <property type="nucleotide sequence ID" value="XM_018295328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V383"/>
    <dbReference type="STRING" id="759273.H1V383"/>
    <dbReference type="GeneID" id="28859435"/>
    <dbReference type="KEGG" id="chig:CH63R_00353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00353"/>
    <dbReference type="eggNOG" id="ENOG502SMKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012508_3_1_1"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12094">
        <property type="entry name" value="TM_ErbB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497577" evidence="5">
        <location>
            <begin position="25"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="606" mass="66294" checksum="9B29DAC282CDAC3D" modified="2012-03-21" version="1">MFLCSLSQAALLCLALHLPKVANAEAKRDWGLAAAPPPSLFLRRAFATVGVLGDFAYIDGGEVSQLDADGRPIKSYPSNGINSTLSIDLSESWSASEVKIRELPKQPQVRNRQGLWKNEATNTLWIWGGSSVNGAPRENTESWKFDADGQGGGKWSREEPTNPTFFSELRRSAEGAFASTEDAGFWFGGRAIGRMNRDKDSYVQPVPGILSYNMTTKTWANETTNAFSENGTVSGGNALYIPTFGPNGLITLLGGSTWGLDVNPGAPTGWLDFYNLTFFDPVTRDWYWQKTTGNAPTARQDFCSVGASGTNGTYEIFVFGGTNTVNTYDDVFVLSLPGFVWTQVIYDAKNPRRFHTCAVVGRRQMLSVGGSDGQTGWSGVDPWPQGLGLFDMTEWVWKTDYDANAKDYEASSVIQDWYKKNDASSIEWSSDRVEALFNQTNSRASVDRDENANNDGKSSNSTVPVTAIVGAVVGAIVGVIIGLALLYFVRRRARNKGTAFAKDDVAPTSQTHYEALPPTELHAPAKQHELDSRQMPGQELWAPVLKPEMAGSDGHHYTVTELDAQQGLLGRNDEDRRDDVCENAVTVYVIMSRGRTCALGSLHLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5M4</accession>
    <name>H1V5M4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_07285</name>
        <name evidence="15" type="ORF">CH63R_00328</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CACQ02001572">
        <property type="protein sequence ID" value="CCF35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163665.1">
        <property type="nucleotide sequence ID" value="XM_018295303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5M4"/>
    <dbReference type="STRING" id="759273.H1V5M4"/>
    <dbReference type="GeneID" id="28859410"/>
    <dbReference type="KEGG" id="chig:CH63R_00328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00328"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011500_3_1_1"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000026">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="669" mass="74899" checksum="7808CE20C9C6A556" modified="2012-03-21" version="1">MGDTSAARKVHPLDPLRPEEISQAAEVVRRSNEHARIFFRAISLAEPPKRVLKDFLDNEHAGNTTLVHPARQARVQAYIDETLHELVVDLDSATVASDDLLRGKHSYIDTEFMAQVAAACLADQKVQKEIQTLKLPEGATVVVEPWAYATDGMKDMSERWTMAWFYMRLSDNPDANYYAYPLDICAEVSNSLEVVEIYRLPSGEHDAIHSVAKEFDRQKIHSNSEYHPDLVPERRTTTKPYHVSQPEGPSFSVDGNHISWEKWTMRLGFNYREGMTLHDVRFEGRGLFYRLSLAEMFVPYGDPRRPYPRKAAFDLGNDGAGVNANNLQLGCDCLGHIKYFDGWLSTSAGEPLRMPNVVCCHEVDDGILWKHTNFRTGNAVVARSRVLVLQTIITVSNYEYIFLFLFQQDGSVSYEVRATGIMSTAPIDLGTTVPWATVVAPGVAAPYHQHIFCLRIDPAIDGHRNSLVVEESHPIPFAGESDAYNPFGVGYTTKSQTVEREAGLDLDFATNRTFKIVNEGVVNPTTGTPVGFKLLPCYSQLLLAHPDSWHGKRAEYAAHAVWVTRHRDEELFPAGRFTMQSTGGEGIASWIRRRAGDDDDGLSLVRDQDIVVWHTFGSTHNPRAEDWPVMPCEKMVVGLKPANFFRGNPALDVPISSQDGNRSVLVQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7E6</accession>
    <name>H1V7E6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07782</name>
        <name evidence="3" type="ORF">CH63R_01635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001856">
        <property type="protein sequence ID" value="CCF36148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164972.1">
        <property type="nucleotide sequence ID" value="XM_018296610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7E6"/>
    <dbReference type="STRING" id="759273.H1V7E6"/>
    <dbReference type="GeneID" id="28860717"/>
    <dbReference type="KEGG" id="chig:CH63R_01635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01635"/>
    <dbReference type="eggNOG" id="ENOG502SNM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129980_0_0_1"/>
    <dbReference type="OrthoDB" id="5176208at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497618" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19215" checksum="9B16149A8C50B91A" modified="2012-03-21" version="1">MKISEVLLPVTLLLGSALAVDMSKYQAEADVDASFKPFLEALYASAEDYKSTDTFTDFFVPESGRLIVLENTAEGPAAIVKLKQALLPTTGQKHWNHLPNVTSVYTETATQKTYDVLGLIQTRFDGGNCSAAYYSSRFTVLKDSKGNVRNQPHSGSLVAYDDYIVSPAESPTHIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7Z4</accession>
    <name>H1V7Z4_COLHI</name>
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        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07934</name>
        <name evidence="9" type="ORF">CH63R_12659</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001937">
        <property type="protein sequence ID" value="CCF36346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152050.1">
        <property type="nucleotide sequence ID" value="XM_018307633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7Z4"/>
    <dbReference type="STRING" id="759273.H1V7Z4"/>
    <dbReference type="GeneID" id="28871740"/>
    <dbReference type="KEGG" id="chig:CH63R_12659"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12659"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010891_0_0_1"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF36346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="762" mass="84329" checksum="85B31272EF40EA33" modified="2012-03-21" version="1">MFSEYASRFLAQSQSRLSNFAGQVEGNENRPRQPNDWSSRPPRNGGRSFLSRGYGGNPYQAGSSRFGQVGFGSRISTAQDAPLFHSTLDEYMEDDEGDERDREAADMAALHMSRRVAAASKMAESSETEPDASRGSLEQSNEGPGRRYQDRGLRRGIRSSWNGTRSFGGRTRGRDVIDEEGEDIPREGSDRDSDTNPKMVDIGLDSQIQDAEGDHDDDDDDPSASLLNEAPTDSSPPAFQKFRPKSGDRRKFPLRREATQEDDFEETQQAGSDDEALPETVPLAEGEIFKYDPFFAWIFLIALAGLVSTFVLVWLHTGTPKKGWGDTVYTTLQASFHMLAVDTLISVLVSFVWLAALRSFARPLALVILVAVPIIMFSFTLYPFISSYEGRSHGASFQDRAMRWAALVPAISAVVWVYMAYKGRYAIRQAIEILEFSTRILAANTALLILGFGCLALIVSWTWIWMWMFSRIFLGGYFSRRLARFIISVSSWWLGIWFVLMYMWTIGVINAVQRATTAATVSQWYFHRNAAPAPTSAEIVTAALNHATTTIFGSICESTLLALLIRAPLLVLPRRVANILQHIAAMWIPTPIAALTNPLTITYGAIHSQNLHTAARGLSQMDFLSPQRPTTTLTPQVFSSRRSSHSPLLPYRLAKMLLYATRFIMATALGFAGWVMTAKQLSIALPDGMGVRGSAYAYVVGIVASFIGFSVMGAMEGILSGILDAVVICYGSERRMASGGGAYCMEAAYLFGERRRDERGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V959</accession>
    <name>H1V959_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_08254</name>
        <name evidence="10" type="ORF">CH63R_01202</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01202"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="444265at2759"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCF36762.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OBR16022.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
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    <sequence length="359" mass="41879" checksum="5BF057972F4A66AB" modified="2012-03-21" version="1">MSPEAATGDTSNPRDLRSAVLQTTLQEISSRPADLQDCCVICLEEITEGCETQPCHHRNFDYLCLITWLEQQTACPLCKTEIKEVRYDFSDDRKRWKTFEVPERPQNKANAAGASPPSQQPRRYYSQTRPRHPRPHAHASRAFTPSQDGAIARRRAVYRNQLYSLHVGSNRISRYRDLTPQIFASDTELVSRARTFLRRELQVFEFLSPDIDARPQDADPVRRRRANNAEFLLEYIVAILKTVDMQGSMGQAEELIQEFLGRENTRLLLHELRAWLRSPYMSLESWDRAVQYPDVVPKRRRSQSPGASNRAETSGGADGIYPSSWRRDERRRYRREPYESRRSRNDERLREATERYTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCA4</accession>
    <name>H1VCA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_09099</name>
        <name evidence="10" type="ORF">CH63R_04016</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02002672">
        <property type="protein sequence ID" value="CCF37857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160237.1">
        <property type="nucleotide sequence ID" value="XM_018298991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCA4"/>
    <dbReference type="STRING" id="759273.H1VCA4"/>
    <dbReference type="GeneID" id="28863098"/>
    <dbReference type="KEGG" id="chig:CH63R_04016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04016"/>
    <dbReference type="eggNOG" id="KOG0849">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023524_1_0_1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF37857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="617" mass="67401" checksum="05FFEDD61E284F64" modified="2012-03-21" version="1">MATEVEHQMALAPNASTPGSSTPLDTSPTSAGKMNQTPSPSASTHNGQAPSSQSRRPPRKSTLTQQQKNQKRQRATQDQLTTLEMEFNKNPTPTATVRERIAEEINMTERSVQIWFQNRRAKIKLLAKKSLETGEDIDSIPESMRAYLAMQAMESGKGLGGPFLGRTGLLPYGHSNMLIGGDQSGQGKVLIHHLTCRSLSIGKWTRVGQNTMDLIIFYSPDKCTMTYYINNEQAGYKIEYPFAYIKNIFLENQEGDPNKPGGIVIELNRPPNFFMDSSPQANGFFQCGDFTEDQQASQCLVHHLGGNPKVLSGQLAKLVSLEAFMNRNNPHPFIDQQHALSVSAPVSPTGRPSSQPNFAQPHIGMFQESWGINSMHPGMRGPGHKRQRSRSVPMAVDFSMLQTPMPSFYIQQPGEMAAPQTPGPNIYAPIPQQPGGLGPNLRIDTQAGFGLDMRQYPMSATTASPSEFPTSPNFFSQGPEPSPLPASSYNTPYGSAFLSPMANPSPNMIPPSVSPLSFGSHHGEPSIVEQSPPFSMPGRSASADIYHQGDNGSCAVSDDGTGLNEMYSKHTINLPMHPHSPAYGDQGQNDLDMNQLVQFDHVDPNSMSPESMHQTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFH6</accession>
    <name>H1VFH6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_02034</name>
        <name evidence="11" type="ORF">CH63R_07698</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02003246">
        <property type="protein sequence ID" value="CCF38979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157451.1">
        <property type="nucleotide sequence ID" value="XM_018302673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFH6"/>
    <dbReference type="STRING" id="759273.H1VFH6"/>
    <dbReference type="GeneID" id="28866780"/>
    <dbReference type="KEGG" id="chig:CH63R_07698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07698"/>
    <dbReference type="eggNOG" id="KOG4133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049366_0_0_1"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF38979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="293" mass="31794" checksum="DF5588D2E8BCA984" modified="2012-03-21" version="1">MSTSNATKVPLVRISKIADRYLVFDAQDVAVIRRDHNICSVLVGTTPQNPTQNVFLSLPLELLPEEASVLVEKKVGRLVDETSHHLSSLRSSDKATRQGYIALLKDRRHKAQKLLAEDHVKKAATEQTRRAKGAMASPAAPEADDLFGLFSPGTPAHDSRGKSRDSADVNLSLTVTPTTSCGLQAPGGGACDAVRLPAAGALHRHLQSKGYFMTPGLRFGADYSVYPGDPLRFHAHFLATNYAWDEKIPMLDVVGSGRLGTSVKKGFLFGGEVPFMDESPKRVRAFCVEWAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFK5</accession>
    <name>H1VFK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09954</name>
        <name evidence="3" type="ORF">CH63R_03874</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003261">
        <property type="protein sequence ID" value="CCF39008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160095.1">
        <property type="nucleotide sequence ID" value="XM_018298849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFK5"/>
    <dbReference type="STRING" id="759273.H1VFK5"/>
    <dbReference type="GeneID" id="28862956"/>
    <dbReference type="KEGG" id="chig:CH63R_03874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03874"/>
    <dbReference type="eggNOG" id="ENOG502T4KZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1686445_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="156" mass="16806" checksum="EB25A1906FD547C1" modified="2012-03-21" version="1">MPLSGSPSGSSSGPSNPDTRSLERKIRDDLCILSNTASVPWIQFEVTTLGALAELNNEFAQAWGAQMRKDEEDAMDIDGQGDANGGESNNNDDDDDEDDDQGNINVNIDDDNDNNNDNDAPAAAEAAEAAEAAKRTRTRHIKDKHPNQPVPPFNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VG76</accession>
    <name>H1VG76_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_10110</name>
        <name evidence="11" type="ORF">CH63R_06786</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003378">
        <property type="protein sequence ID" value="CCF39229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159611.1">
        <property type="nucleotide sequence ID" value="XM_018301761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VG76"/>
    <dbReference type="GeneID" id="28865868"/>
    <dbReference type="KEGG" id="chig:CH63R_06786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06786"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="77"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="53"/>
            <end position="64"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF39229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="469" mass="50603" checksum="AACCFAB2FC1DAF3F" modified="2012-03-21" version="1">MPRPDHPASPTDSQMTFTEPQAPTTLFKEDPGPADSSSDHPSTIQQPDPEKSAGAPTPAGGAKPSYPGSDAPDGGVVAWLVVLGAWCTSFCSFGWVNSVGAFQEYYQNDLLRNYSPSTISWIPSLQIFFMMALGPVIGKLYDNYGPRWLILVGSFLHVFGLMMTSLSTQYWQILLAQGICSAVGVAAIFQPALNTIHGWFNVNRGAAFGLLSTGSSIGGIVFPIMVTRLIKSVGYGWAMRICAFMILGLLIIANLTVKSLHPPRPQKVNREQLLRPFKEFEFVCVVVGFFLFTYGIFVPINYIQVQALEAGMDPDLAQYLVAMLNAGSLFGRIASGILGDKIGKYNIFVVVCYLTSIWMLALWIPANTDGALIAFAVLFGFCSGAYVSLIAPLVAQISPFQEIGFRTGITFFTNSIGGLTTNPINGAILAGPSGWIGIKVFSGVFCLAGTTFILAARIHRTGWKLAVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VI19</accession>
    <name>H1VI19_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UBA/TS-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_02225</name>
        <name evidence="10" type="ORF">CH63R_08696</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003746">
        <property type="protein sequence ID" value="CCF39872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155693.1">
        <property type="nucleotide sequence ID" value="XM_018303670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VI19"/>
    <dbReference type="STRING" id="759273.H1VI19"/>
    <dbReference type="GeneID" id="28867777"/>
    <dbReference type="KEGG" id="chig:CH63R_08696"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08696"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047594_0_0_1"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
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    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
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    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="251"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF39872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="316" mass="35000" checksum="304B4553C165F350" modified="2012-03-21" version="1">MTQSDLDQLLDMGFEKARAELAVKKTGNLNGALEWLEANQDKPLDELTAAASSTAAKDDDDDAGEVQANIDALESGATAKSLVCNECGKRFRSQDTASYHATKTDHTDFSESTEEIAPLTDDQKKAKLDELREQLKEKKAKQALLDKEEAKRNEKIRMKATKESQEAKEELQRKEQIKEAAKKRQEKQDDLEAKRRIKAKIEADKEDRRRKAEEAKAAREGRAPAPVPVAAPSIPKATANHNEARLRLQTSGGNILKTLPAETTLFEVAQMLQSENGLEVTSFSTTFPRKTFEGHMDLSKTLKEAGLTPSAVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKE2</accession>
    <name>H1VKE2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Duf1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00366</name>
        <name evidence="4" type="ORF">CH63R_03786</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004235">
        <property type="protein sequence ID" value="CCF40695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160007.1">
        <property type="nucleotide sequence ID" value="XM_018298761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKE2"/>
    <dbReference type="STRING" id="759273.H1VKE2"/>
    <dbReference type="GeneID" id="28862868"/>
    <dbReference type="KEGG" id="chig:CH63R_03786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03786"/>
    <dbReference type="eggNOG" id="ENOG502RR78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF40695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="281" mass="30040" checksum="B0B932BA72013B1E" modified="2012-03-21" version="1">MSATEANYGAVTTSAPVVNGDSRASADEEQPLLGAAGGKPASKSLRKKLTTDVTRDWADLVLLTCYIITGLLDSSSISIWGSFVSMQTGNTVYIGLGLAAPTESTRWIKSATSLGSFCLGSFFFSRFHRLFSPKRRWVLCASFIAQTLLCVAAALILTLGPAAGKDEVSWNVLVPIALIAFQSCGQAVTSRALRYNALTSVVLTSIYCDLFSDAELFVVRNAERNRRVGAPLLLLAGAVLGGLFAHSSLGIAGALWTASFFKFLVVLAWFFWPGESTSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VM80</accession>
    <name>H1VM80_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH063_02573</name>
        <name evidence="20" type="ORF">CH63R_05395</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02004634">
        <property type="protein sequence ID" value="CCF41333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158220.1">
        <property type="nucleotide sequence ID" value="XM_018300370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VM80"/>
    <dbReference type="STRING" id="759273.H1VM80"/>
    <dbReference type="GeneID" id="28864477"/>
    <dbReference type="KEGG" id="chig:CH63R_05395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05395"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000118">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="18">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="15">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="17">
        <location>
            <begin position="686"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="16">
        <location>
            <begin position="779"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCF41333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR09703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="853" mass="97319" checksum="8D27088313CF2A91" modified="2012-03-21" version="1">MASRTVIPIDKKWQFKQADKDDSDLLAVSQFPTNVHLDLIHHNIIPDPFIGKNELDVQWIGEKQWLYKTTFASEAIPEGAQAVLAFDGLDTFATVVLNGKTILETDNMFTPERVDVTAVLAKEGGDNELVITFDSAYLRGWKLVEKYPDHKWGCWNGDNSRLAVRKAQYHWGWDWGPTLLTCGPWRPINLEIYESRLSDLYFETTVDDSLKSAKVVAHATTEGSASKVRFDVSLDGKSLASETVDAKADADTSATFQIQDPALWYPIRYGEQPLYTVTATLLANDNEVDSLSKRIGIRKVELVQRPLKEQPGTSFFFQVNNVPVFCGGSDWIPADNFIPRISKERYYDWIRLLADGNQFMVRVWGGGIYEEPAFYDACDELGILVWQDFMFGCGNYPAWPELLQSIDREARENVKALRHHPSIVIWAGNNEDYQYAESENLTYDLANKDAQSWLKTDFPARYIYEKILVDACEDLIPDTFYHFGSPWSGQDTRDPTVGDLHQWNVWHGTQEKYQNFDKLVGRFVSEFGMEAFPSVKTIDAYLPKGKDDPDRYPQSSTVDFHNKADGHERRIALYLVENFRYAPDPLEHFVYCTQLMQAECLASAYRLWKRQWKGPGREYCGGALVWQINDCWPVTSWAICDYYLRPKHAYYTVKREMAPISIGITRTEHKHPRDKYTRVNIDTESRIEIWGSNLQLEDLTVDLVVKAWDVETGEETYHETVDKDFVLPENRSTEMAAFAVPVRQKGDEGRTVVAAYLVQGGKQIARYVNWPEPLKYLHLQKPKSLKAELAEDGDVVEISAEVPVKGVALEVEDDGVVFSDNLVDIVPGEVVRIGVKGASKETKLETRYLGMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VMM2</accession>
    <name>H1VMM2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11740</name>
        <name evidence="4" type="ORF">CH63R_01743</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004719">
        <property type="protein sequence ID" value="CCF41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165080.1">
        <property type="nucleotide sequence ID" value="XM_018296718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VMM2"/>
    <dbReference type="GeneID" id="28860825"/>
    <dbReference type="KEGG" id="chig:CH63R_01743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01743"/>
    <dbReference type="eggNOG" id="ENOG502R6FV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1643590_0_0_1"/>
    <dbReference type="OrthoDB" id="4848194at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497710" evidence="2">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="165" mass="17230" checksum="843FDD541C74C834" modified="2012-03-21" version="1">MRVSVLALALSSGASALPALGGLAVRQASHLANRNVEFKGAEAPSLIDDMNLSRAESIAVREEMTADTQKRSMAVEPRQAAKTGGKNAQEGAPRIEAIDDNKKNPKTDLTDREAAEIVSSIDLTDKKAAGSLDAKGQRNPLPGLSAEMTDLIIKQGLAALKEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VN97</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">CH063_11904</name>
        <name evidence="3" type="ORF">CH63R_04630</name>
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    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004873">
        <property type="protein sequence ID" value="CCF41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160851.1">
        <property type="nucleotide sequence ID" value="XM_018299605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VN97"/>
    <dbReference type="STRING" id="759273.H1VN97"/>
    <dbReference type="GeneID" id="28863712"/>
    <dbReference type="KEGG" id="chig:CH63R_04630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04630"/>
    <dbReference type="eggNOG" id="ENOG502SD0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386840_0_0_1"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
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        <location>
            <begin position="39"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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            <begin position="308"/>
            <end position="319"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF41701.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="729" mass="78303" checksum="76577171A5ABF6CA" modified="2012-03-21" version="1">MFKVVNRSRSMKSMRSGGGAPGGTQTHGPESPVLGSPGLVSSFQQTKEDSSVSQNVVVPFAEDAATAAAAAAVAAVETRNTYRHRPLPTPPRSKASSTMAERPSTSGGLSPHNYSTTSFRTFDRRMSKDDMYIRPHSSARGGYKSYHIPIRDNPASPLESPGDFSYDFSPARTFTVRTQTPDSMDSNMGTIAIGMAIGSPTHPPPEFTASREFLATPIPAPRNEWQPQASSMSTSMVVRASPEPPQEAPEPVPPPKQKSGRWKLFGRSKSKRLASSPVAISQPMNLQQSAANRTDFDISQTNKQSGDLGRRNTERKPADSKPAMMRSQTAGPVAPPSPRDSKAPKLLSRMASTRSTRSVKKSDISAPVHVSMGVPALPPKPSGGFLDVEIPSITMERYSVMFGNVLGQPQGSEDSMFGQQPSQPSSSLLARRQATLDRLKTVNAKATKEDEERERTRSRRATSPQPLKSPAFSLSLFPATPSESANNPPQSPRYRSNTSPAFLASPQRASFEHAETHREATRGKTPSPGIVSHLRPHRPQEPPAPDFVFGPEQSGLVLESPAGDDESEEIHLTEQLKPTIYEPAWQMMTPADSTAPSSTAPSAKDHSPASASSVQTHVTKPSFDGSEPDDALRAAVEISIARQISISRQQRRMLRPLKTNAIRVGGGGGGGGGSPGARSPVATITVGKNERLSSTKSATPTLISPGETFEQQIAQNRKSERIILEGEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VST1</accession>
    <name>H1VST1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMP-30/Gluconolaconase/LRE-like region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_13038</name>
        <name evidence="3" type="ORF">CH63R_13058</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005989">
        <property type="protein sequence ID" value="CCF43289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152449.1">
        <property type="nucleotide sequence ID" value="XM_018308032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VST1"/>
    <dbReference type="STRING" id="759273.H1VST1"/>
    <dbReference type="GeneID" id="28872139"/>
    <dbReference type="KEGG" id="chig:CH63R_13058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13058"/>
    <dbReference type="eggNOG" id="ENOG502RZSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036110_1_3_1"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="36600" checksum="BACDE19E7C7CFF7D" modified="2012-03-21" version="1">MANASAFVVYNDRVKTLFGPAPTLELLHENQDYPFAHEAGVFIERNNTLFVTSNQFSDHTAGGRKIQICRVTLPPPDGVTKAQCEEIHPAIITMANGGVNYLDGIVFCAQGTMDSPGGLVFMEAEPPYQTRMMVNSFHGREFNSLNDVVGHSDGSLWFTDPIYGYEQGIRPRPKLPNQVYRYDPIHGSIRAMADGFGRPNGICFSPDEKVVYITDTDWIHGDGSTDLTRASTIYAFDVVSYSGEPFLTNRRLFAMASEGIPDGIKCDVHGNVYSGCGDGLNIWSPGGVLLGKILVQGGAANFCFGRNGEVFILNENRLWRAKLADETKGALLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTV1</accession>
    <name>H1VTV1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal rna-processing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_03129</name>
        <name evidence="8" type="ORF">CH63R_10374</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006268">
        <property type="protein sequence ID" value="CCF43659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154772.1">
        <property type="nucleotide sequence ID" value="XM_018305348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTV1"/>
    <dbReference type="STRING" id="759273.H1VTV1"/>
    <dbReference type="GeneID" id="28869455"/>
    <dbReference type="KEGG" id="chig:CH63R_10374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10374"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="343"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1096"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1166"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1208"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF43659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1259" mass="137952" checksum="D5E3CD6B9D6E053D" modified="2012-03-21" version="1">MSTPTLAEKLDKIRSPGLQSQKRTAVVLDAVDTTLKEQNAQPTPTGYFAALLALLTQAVESGNISSDTTTSVVYLLDIITPFAPQPLLRAKFTQILTSLAPVLLQQDAEALLLRSSIGCLESLLLAQDSGAWELGVTQIGPRRAVAGLLNLSLEHRPKIRKRAQEALRNVLKNPPPSPSLDHPAADMCAHTALANLEDIAGKAAQARKQKGAESAHDPALIHSLQLIKTIASASGGWPSKKIESLCELLLGISRSGNEYMTMATFEIFEMIFEGMADEVASAKLPRLMEIISELRPAANDTQLIPPWLAILSRGYDVSAQIEPDDVFQNLPEIFSMVAQYLESPAHNIRISASECLVSFMANCIPKQVILEPSIYDEKTLDKIAKIAESLLSVKYQQAWMESFNVFGAMFDSLRWRAHPMMLNITKAVGELRGSDSFQGKKEADEVIGKAVRAMGPEAVLSILPLNIAKPAKGQQGRAWMFPILRDYVSNTNLAHFRQEMVPLSELMFQRVLDHGKAEKTMEVKIFETLVQQIWATLPGYCDLPLDVTETFDQSFAELLANILYKQVELRLEVCRALKVLIESNQAIATIEDEGEEDLVLQSRVSRAVAKKNLEHLGSFAGNMLAVLFNVYTQTLPQSRGPILLTINAFLSVTPEKELIDTFDRVSKMLAEELQQTANQEKPKQQQKQGAMPSTSNTLMDLIITIAIYLPRESYTALFEIASVIIFKENEPQLQKKAYKLVPRLTESETGKLALQARSDELQQMFLTSAEKVSAPARRERLGALSALLPYIPDTSLHFIPSILSEVVICCKENNERAREAAYDLLVQIGHRMEAANGVPIDNTKVPHMPEGAPAGKASLEEFLTMVSAGLVGSTPHMISASITALSRVLYEFRRSLTTETLADLVQTMDLFLTSNNREIVKSVLGFVKICVVSLPSELVIPRLSSLVPNLIIWSHEHKGHFKSKVRHILERMVRKFGFDLVNQNCPESDRKLIVNIRKTKERSKKKKDAAKQAGEESDEEEGRQGRKFDNELDQALYSSDSDGSDNESDDEGAAAGPKGKRNNRKGGNTYIVEDEDEPLDLLDRNALANISSTKPVKMRKPTKTKARTDLDGKLILGKDDDEAMEVDGAENDGSGVNAYVAALKGKDVAKRGLRGKLKFSNKRGQDDEEMEDLDEGDAAAVKAQVDKSRGGGKPFRGGRGGQDRGGRGGRGGRGGSRGGGRGGKGGIAAGRKGLGEDRRRGGPTSSGGVNKGRRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVW6</accession>
    <name>H1VVW6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_13799</name>
        <name evidence="5" type="ORF">CH63R_01763</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006857">
        <property type="protein sequence ID" value="CCF44377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01763"/>
    <dbReference type="eggNOG" id="ENOG502SHHA">
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    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PCBER_SDR_a"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NmrA-like"/>
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        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF44377.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VVX0"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01308"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF44381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="264" mass="29191" checksum="698A359F64995ACF" modified="2012-03-21" version="1">MSISQKPPVPISITICGDGGCGKSSITLRLVRSQWTSEYDPTIEDSYSITRKIDGQNYHLSLTDTAGQEEYRGMWASSNLGADAFLLVYDITSRDSLDALQYFNDLIDMEAETRLDNADRAKRAGLSPSSYRDTVSATPGAKTVPPVKIVAGNKCDLQESRDVPAAMGLDWARRRGCGFMETSARLEVNIEETFALIVRRVVEARRMAELGVNENMEMDRRGMTKPLSPLPTGSENEKHGPGPQGLNVHSKMGKGSIWKKLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2Y4</accession>
    <name>H1W2Y4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_00640</name>
        <name evidence="5" type="ORF">CH63R_06516</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009123">
        <property type="protein sequence ID" value="CCF46847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159341.1">
        <property type="nucleotide sequence ID" value="XM_018301491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2Y4"/>
    <dbReference type="STRING" id="759273.H1W2Y4"/>
    <dbReference type="GeneID" id="28865598"/>
    <dbReference type="KEGG" id="chig:CH63R_06516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06516"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074138_0_0_1"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF46847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="278" mass="29677" checksum="127A163E1EF2CDA0" modified="2012-03-21" version="1">MSNTTVHVKNIASATEDKEIKDFFSFCGKITNIEVTPAGETKDAAVTFEKETAAKTALLLNNTQLGTSHITVTSAGGDPSDDAPHHKENASRDSDDITQEEKPRSRILAEYLAQGYVVGDAALQRAIELDSQHGVSNRFFSTLQSLDQKYHATDRAKATDQSYGITAKAQGLFGGLSSYFEKATSSPTGKKIVGFYETGSRQVQDIHAEARRLADLKKEEHGGSALKASGLERFLGKEKSVPPATGETVGTQSPTNPDPTTAVPLSKPSAATDEKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3U1</accession>
    <name>H1W3U1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine-threonine protein kinase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04069</name>
        <name evidence="4" type="ORF">CH63R_00552</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009423">
        <property type="protein sequence ID" value="CCF47154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163889.1">
        <property type="nucleotide sequence ID" value="XM_018295527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3U1"/>
    <dbReference type="GeneID" id="28859634"/>
    <dbReference type="KEGG" id="chig:CH63R_00552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00552"/>
    <dbReference type="eggNOG" id="ENOG502S7IU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036328_0_0_1"/>
    <dbReference type="OrthoDB" id="3980126at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43470" checksum="67B6A6CC631BA95C" modified="2012-03-21" version="1">MSLRSILGGGRVKKPKSKPKASASPRKNDGTNSPRPGSSAKRKPVPAGANVDDNDDDDDFFHDRLDDVGLVAALATDMSLRDVVQAIKYTRGRMFGPVPTEAAGMRSTRIAEVLNYRKAMPGIVTISHLHALLASPTAVEREVAELQRGGAVRKIYVQRRGGLGEALIQTSELEEMVAQSVGLDEEAKTAFLKFLREHPLAQTMPRSASGHKQADALVRAGFLTASIHPQHVNTPLMNLHLRPEDRGSLTSIEAVSRAASGSFDAVGGQGAVYAAGGGGGAPRLPRADSSCSVAEFTIAVPGNGSFLKLTAAAVDHLTRLLSKSQFREMPVSMLRERWEGGVARDEARLARRARGEFAGVLPGRTKRWKEFYGLEFDWVLEEAMGAGLVEVFETRSVGRGARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W590</accession>
    <name>H1W590_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04232</name>
        <name evidence="8" type="ORF">CH63R_04766</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CACQ02009978">
        <property type="protein sequence ID" value="CCF47654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160987.1">
        <property type="nucleotide sequence ID" value="XM_018299741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W590"/>
    <dbReference type="STRING" id="759273.H1W590"/>
    <dbReference type="GeneID" id="28863848"/>
    <dbReference type="KEGG" id="chig:CH63R_04766"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04766"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050461_0_0_1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF47654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="288" mass="31776" checksum="797CE886DE438989" modified="2012-03-21" version="1">MPHFDESKAYAVQEDVFFDDGREIELLHFVYSQPDLDEIRGSPERVLKAVDDFGRTKKYLMNVGEDKGKIVTDLITEVKPKIMVELGGYVGYSCILFGAAARAATPNARYYSLERNPEFAAVIGSLVDLAGLADTVKVVVGPSDASIARLHAAGSLPRIDLMFLDHYKPAYTTDLKLCEQLGLIGPGSVLAADNVIKPGNPPYLEYVRSSVAQKRAAARDVGKARVESGWHDDRTAKQYEKREGEERLDLSRIGNPNLNYESQLVHSFEPTGVPDGVEITRCVGEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQT2</accession>
    <name>A0A1B7XQT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Duf323 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_14412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150629.1">
        <property type="nucleotide sequence ID" value="XM_018309386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQT2"/>
    <dbReference type="GeneID" id="28873493"/>
    <dbReference type="KEGG" id="chig:CH63R_14412"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14412"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF2">
        <property type="entry name" value="HISTIDINE-SPECIFIC METHYLTRANSFERASE SAM-DEPENDENT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="35"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="314" mass="35258" checksum="3606AD39F62A180A" modified="2016-11-02" version="1">MSPARSSRAIVSLALGPRRWRSEAACFSGGEVPCLPDELIYDDANIIYTPEFYQTHEEIALLQRYGSEIAKDQIAEGAVLINIGAGDLNKANYLLEELRRRGRKVTYLALDISKRSLTTNLCDYAPGDKGVSVYMAGLWGDFRAGVAFAATVTQKPRVFLSLGSVLFNDPWQKAVGSLRDLILAGMDGHDVHSSKVWAAYHSRPDLFEEFFHNGFLHANKLLGEDVFHPGDWDIRAEIETEEKRHRFFLQARRDIVSEVEGRIKKKGLAIDWFDADKRSEEDVRSMCAEAGLEVVQLWACKDSDMRQYLIGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSD1</accession>
    <name>A0A1B7XSD1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Subtilisin Carlsberg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_13901</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151193.1">
        <property type="nucleotide sequence ID" value="XM_018308875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSD1"/>
    <dbReference type="GeneID" id="28872982"/>
    <dbReference type="KEGG" id="chig:CH63R_13901"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13901"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601017" evidence="10">
        <location>
            <begin position="20"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="190"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="12">
        <location>
            <begin position="663"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR02675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="938" mass="100290" checksum="83490832564D891E" modified="2016-11-02" version="1">MRVSSTIISALLGANIAAANPLHPRVFPKNEPAIVAKASLDESANQDQKSNNELLPGVYIVEFADDNDTPTSFYEGLKADGLEVESRMDLSNSLFKGVSFQVKNQAATQHDAALFRRQMEASPRIRNIWPVRTIQRSAPEDNGGPIKNNVKHARHARRQDNNTTGNSTKDTFSPHVMTQVDKLREQGITGKGVRIAIIDSGVDYTHPALGGCFGPGCIVEAGWDFTGDDFLPGVRPLQPDADPMDDCAGHGTHVAGTIVAQLEGNEYGFTGAAPGVKLAAYRAWGCASVGTNEILLAAFIRAFDEGADIISCSDGDVAGWAWDAWGVLAARIVDAGVPVVISEGNDGGIGMFFASSPATGRGVAGSGAVTNSKFPTILNEGTFTVASNSTGGSESTFAYLAGVPELVGDLSLQLWTPGENNACSDLPDSTPDLSNKIILLEFPNSRATGCYPIDQGDRLVTKGGRYILYNTNNNTLRGRSTMRDQQYVYSQGIQGVASIPPYQAQQWLSLLEQGRNVIVSIPNANNTKTRLEELENNSGGSYMGTFSSWGPTWELEASPQFVAPGANILSTFPVALGGYRVMTGTSMSCPLNAAIYALLAEAHGTKDPKRLRSIVASTSKPLDWYDGTVVHPDILAPVPQQGAGIIHAFDAARSTAVLSVDSISFNDTDHFVGNKTVSIHNTGSADLVFEVSHRKAVSMYTFMANQDRLRAASFPNPIIKEWAELQFSSDKITVPAGGSAELTVTCIPPSNVNATLLPVYSGFITFTSTTEAPSLSLPYLGVAGSMYDTRVLTSSQAFLANYNSEAPANHTYTIPRPDPANPPRTDRGDTGSTPNVFISPTVGTAAIQVDVFRVSGGREENLGSLAGWPLSFVSRSEQRAYFNGLLADGTVLEPAVYSMEVRALRIFGDREKKEDWDVIKTVPFILKYSAAGNGTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSP8</accession>
    <name>A0A1B7XSP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151311.1">
        <property type="nucleotide sequence ID" value="XM_018308993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSP8"/>
    <dbReference type="GeneID" id="28873100"/>
    <dbReference type="KEGG" id="chig:CH63R_14019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14019"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="717" mass="78452" checksum="785FD8B096F9A82B" modified="2016-11-02" version="1">MCKRVEAARWSALRDEDAARLRLAKGSARDRTPTRDRQNEDHRGEDHADENENARRILGCDFDGAADHTSPVAMLDRENASLRQIFEQQQQQQQQQQPLSFLGDEANDDAGYAARLSPSLPLGVFPFSRPPFEASNRFDFLSAVPETSRRMIPSLAPDTRDPLALWNACASEADAPSWEDMLDFPDPSSRAQTPPLGGGEEDTTTLSTVVRQRGAGMTEDSLLGTFERDVAPRIALQLLPFTDLFRASTGLRAAALALTTSYLRLCRTSDPEPTSTGTRPGPAATGVHCHYYYFAVADLAHQVEMCPGPDAAADALVCAAILLVYRDIAVGSHRDVCGHLRQLEALSAAVDDLASRCHPALLRAWRLFSFDMRLCSLVTRKSVAGPPPPPPPPQQMCAPWDSRLTIRDIFSSLWRLHGRAVIEASFSEPGGGGGGGGGGPAAARRQSASRRAVQWLCSVFGRRCDLRQWEQRDYHDETLSDDAIATQCRVFESRLDAWHRATARNDLPVPCLGAGAEGVVAWGGGGFGAVVPYDIPDRGAAIDYSLYLISRMTCLHLQSRYQARRDPKHASALDSDVLARVALGILLKAGPAWPTAALGEPNVLTLLYMTALVSEGAAVATAVLEGVLPRFGRDGGDMPAVERDEMLYMERLMEVVVRERHRGRSVRFAIDSYDEDHRRDATCSARQRRIAVFGDFGGRGHFRDVVYMGANACTDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT97</accession>
    <name>A0A1B7XT97_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_14180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151472.1">
        <property type="nucleotide sequence ID" value="XM_018309154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT97"/>
    <dbReference type="GeneID" id="28873261"/>
    <dbReference type="KEGG" id="chig:CH63R_14180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14180"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="684"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="727"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="839"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="945" mass="101248" checksum="D6D758E8329A1EA7" modified="2016-11-02" version="1">MMHFLGHRRSASQQSIDPETQQQPQQQWRPHHKHRLSASSALYQAAQALGSIGVPTAAATANAATANAATASASLPADAATANSNSSHPLLPNPVPSSSAVSSHSQSQQSSASSQYSQPSPSSPQQQRQHHRQSGYFQPNHNHNHNQPPLTSGPVSSPQTSSLQYTPGAASATKPATGSSLPNEPPVANFRWDDEYYNTRDRDDTDRDSNPAAATTDSASVRSLQPHQAHSYSHSHSHSYAHTHSHISSNNTRAHSRSQSYSQQQQRASIPAALLPAHGLQPHRDSTYSLSARSTATETSGPPGLTPSIALFPDHSSPSPSSSSAAAAMNQQQQQQQSPPQFQSGTPRRAGTYSSQHEELHMPAGMMQHGQLSPREYSSSSTAPAAPHIKLDQASPNVPQYQNTSSVPNVLQPGGPGNRPPVLTANTAPALSTMQPQQPQDYQTPSKPPSLSLSHSYSRSSPAAGYEGASTFAPYTPTTPSGSGSQFMSPPDQKYNAPGSQRNISNTPLGLADIRPRADSSMSDGVPGSVAYELANAQPGTSNYLAPWALYAFDWCKWPPQGHGAGKLAVGSYLEDGHNYIQILDTQMVPTPNDVYQPGTPKFNLEFSKVAEATHSYPVTRLLWEPPSSQKQSTDLLATSGDHLRLWSLPSESPVSQSNSITRQGRDTAVTKLTPLALLSNSKTPDHTAPLTSLDWNTVSPSLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGQDGSVRMFDLRSLEHSTIIYEPTGKDDRDANGGRISPTLAQQTMSNPPPLLRLATSPHDTHLLATFAQDSNVIRILDVRHPGQALLELRGHGGSLNSIEWSPTRRGVLASGADDCQVLLWDVYNNNHSLSGGPPANGAAQPDNTRSPYASWQCDYEVGNLAWVPHLSSNDQGEWLGVSAGRGLWGVKTCGRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTY2</accession>
    <name>A0A1B7XTY2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151745.1">
        <property type="nucleotide sequence ID" value="XM_018307328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTY2"/>
    <dbReference type="GeneID" id="28871435"/>
    <dbReference type="KEGG" id="chig:CH63R_12354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12354"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="388" mass="42936" checksum="EC90E695B2E86C7E" modified="2016-11-02" version="1">MAADMGLTNNPESGKPVYQPVAPLLNRIVYGTKISTLQQWYFQKAGFEAWKSYFWPPAQRPDIIKQYDCRKALPVRIFFPSNYDQTSPQTLPTLVTIHGGGFCIGVPDDDDAWNRTFADLNGALVVALHYWKAPWAPWPRALHDLEALYLAVVDDASLPIDKGRIALAGFSAGGNLTLCLSQMRSVRDHATAAPGAIVPIYPPTDFVTPTAEKHDRRPYKVGAGLPGIRGEKRDFVLEFADVFDWSYIPYGTNLRDTLISPLYAGRADFPGNVCIVAAELDYLAYEAWELACKLGGKGRPPAARVGRDEAAPGAPRQELELRDERFAWEVEDARGSVKWLLVPDVIHAFDLHEMGAAVSDPATVRDGNAKAVKVMGVIGDWLRRTAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUM7</accession>
    <name>A0A1B7XUM7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_12580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151971.1">
        <property type="nucleotide sequence ID" value="XM_018307554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUM7"/>
    <dbReference type="GeneID" id="28871661"/>
    <dbReference type="KEGG" id="chig:CH63R_12580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12580"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="360" mass="38985" checksum="C9D6D04D948F8AF2" modified="2016-11-02" version="1">MSYPEKFEGFCVAGPKSWNEFKKETLTPKPFGDRDIDVQIECCGVCGSDVHTITGGWGEYEGPLCVGHEVVGKAVAVGKSVKEIKVGDRVGVGAQVWACLKCDQCKNENENYCPHLVDTYNATYEDGSQAHGGFASHIRAHEYFTFKIPDAIKSENAGPLMCAGLTTYSPLVRGGVGPGKTVAIVGIGGLGHLGIQWAKALGAEVYAVTHSPDKAEDCKKLGAKEVIVTSEKDWAKPYAFKFDFMLNCSDMTNEFDLQTYLSTLKVGGHFHMVGLPDKPLPQFPAALFTTNSAKMSGSHIGNNQEMKALLKLAAEKGIAPWVETIDISEAGCKEAVERVKENKVHYRFTLVGHQKAFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVP0</accession>
    <name>A0A1B7XVP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentatricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152370.1">
        <property type="nucleotide sequence ID" value="XM_018307953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVP0"/>
    <dbReference type="GeneID" id="28872060"/>
    <dbReference type="KEGG" id="chig:CH63R_12979"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12979"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="679" mass="76532" checksum="DB7384A608A70980" modified="2016-11-02" version="1">MYGHCLVSAKREHGRDGVLLIWEAVEKLRSLHDVTSEEAELFWSAILEAVLHDEDSLKDVVLFSEWLLRTHSAQWPSLYSKTISYCLRNGQYLRAMQWHLRLMPNFDPGPKIFGALLQEFAIVPGAEMQQTLQALYVASLHHSSYDELIPLLYRNGLSQDCNGWRDLFINHHDLPQPTAESQPYLKYLARYYPTITLELEEQMIVGLNSSTYWDVHYDSLWDAMKQYTHGDDSDSPGRRHSDTLGARWFASSWVPLDFAIHAVHALGVRQIGPLSLQSIALREPIAHRVVARIEQLRKINIDIGHSAYSQVLKRFAENEDNELLHELLHTDIHPDVFDDPPMLASIRDKALKEGAWETHRLLVAIQPAIVEESVDLTSNLLLQESVKYGQSRQALALLDDMRTMNIDVSMSTVQHICWSILDILPWNPKTTAVNQEALNTAIAYLTRLTLLKKPVHSHYWQKIIFGLGKFGRIGELEELCIGIIDTYEKLCISEGGLLPVHYLDAPPLGMDGSTNDVLVPADLPIAHEHHPVRRIFDNAALHAAIVRWGFKAGFSKPCSSWGPLPSSMAAASEYSVARGVRFLAILNGRGIPFRAAVVQDQVVRCLARAYLPQNKGASRRRVDLPPLKNMSELVNRAAGRDLLPSTAKLRDLMEDVYPGKSTASMATRSFTSSVIPHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW34</accession>
    <name>A0A1B7XW34_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152479.1">
        <property type="nucleotide sequence ID" value="XM_018308062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW34"/>
    <dbReference type="GeneID" id="28872169"/>
    <dbReference type="KEGG" id="chig:CH63R_13088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13088"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="134" mass="15110" checksum="72FBD640B3AA3CDE" modified="2016-11-02" version="1">MWAIRQDKSEVRMRVRSERPTDNSRAETMPVRFAIAEALPGKPLVRSRENLQEKTAQLPPRRPGFSQQTLRRTDDSELWDGARWPINDTGAQRDRRSGQLPVGNSRNAIPSFLAPNLILGDRYAVQDFVGSPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWS5</accession>
    <name>A0A1B7XWS5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152741.1">
        <property type="nucleotide sequence ID" value="XM_018308324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWS5"/>
    <dbReference type="GeneID" id="28872431"/>
    <dbReference type="KEGG" id="chig:CH63R_13350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13350"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="451" mass="51301" checksum="CEDAD076F061AB60" modified="2016-11-02" version="1">MSSRPRPPPGPKTCIHLEHGWFDPKVGLPPRPLREPQDVLEELLRNLIASGNANDDATFLSGLLESASKHRATTKTEDPPQFHQFSRLPLRIRNQIWLFAIPSRTVHVSVDAQEKACWNRRLPIPAPALACREAWLVIMPLVHDVTKCLYISRGPGGCTIEDSWPVVKEERRVSWFTSADTLSVGGAYYTCETLDWFYGRNVPITADTAIPLRTLQEQVNITTFFQSHNCVKVVLQTIDIVVAKTTKTSGKFSRVKDGVMAFRNPVTFVNVKAVKDWSRHERDPVDRDVAFGPPPNFGFHVAHNVELHDRARLEELLSLVSAMGGSSWDACAGKHRLDAMEDWTRAFCFDCLMTWWEKRGRDLTEETFVKHRRQGMGTKNTIGDKPKEADEVDARMSRLIPTVRFLVRFQDIVPPGTPLEEPQVRMLAPHLDFETHGHLPDWMINDFEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXG6</accession>
    <name>A0A1B7XXG6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152959.1">
        <property type="nucleotide sequence ID" value="XM_018306118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXG6"/>
    <dbReference type="GeneID" id="28870225"/>
    <dbReference type="KEGG" id="chig:CH63R_11144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11144"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="186" mass="20616" checksum="549BCA65B5FA3BDD" modified="2016-11-02" version="1">MANKRQRNAMNSGPGSGQLDGPLSFGSCFSPAFPQITCRNANAGQLSRPQSISRQTQTHWFSQPCRRMHSLAERGLQCSSVKPLNFPLLTNTQCQSPEPYRDLHRRQSYQGNKPLTDGGSTLTLHVLDGLSDPDVSTTQGMDAWRKGRNRGLPTMWPERGDDLKRQNKSIHTTVEINTGDTISHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYM0</accession>
    <name>A0A1B7XYM0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153395.1">
        <property type="nucleotide sequence ID" value="XM_018306554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYM0"/>
    <dbReference type="GeneID" id="28870661"/>
    <dbReference type="KEGG" id="chig:CH63R_11580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11580"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="397" mass="44514" checksum="76D5679A73D339B4" modified="2016-11-02" version="1">MAAQGEETPSSSAAAIAAPTAPAAHPEEAANPATGLIDPDDGETDSAINVSIRDSLTSIRSSLLNFEDEYGRLYHSHSRGSEKSNLSWAVVISNHALTEYFFPHDNIEQDRLDLQHELFVRTFRGRLCTCPKFYGAKRVLDLGTGTGIWALEYAEEHPESEVRGLQLINFVISRLSLTTPQVIGVDLSPVQPDFMPPNCSFEIDDLEKPWTWSKSFDFIFSRTLNGSILDPVKLVDSIYKQLEPGGWFEAQDVCMSAQSDDDTIPENSSLVQWADEVVDAMEKIGRSLKLAMQWKQLLIDRGFEDVQETIYKWPTNTWPRDKTMKDIGGWGLANLDSFLESAALGTLTNIKGWSREEVLVLCSQARKEMRDPRIHVWWPVYVVTARKPGLPIQAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYV7</accession>
    <name>A0A1B7XYV7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153429.1">
        <property type="nucleotide sequence ID" value="XM_018306588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYV7"/>
    <dbReference type="GeneID" id="28870695"/>
    <dbReference type="KEGG" id="chig:CH63R_11614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11614"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="19708" checksum="2DD9ABBC7137C76B" modified="2016-11-02" version="1">MLRNFAHTKTLLDTLRGIPPSSKVACPIIITPKGIASKTRSPKPVRTIGTEYRVLLDKRTTMFGSPWVASPRAFRREAHPPAPTQLGQLLENLRQQLAAIQQQLVQPQPARSRGLSPAVELTSLDLSSPIRYTAPIPQGNRDICYPVTPKDVKGAASCRIDSTPLLREMRHWTDDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0Z5</accession>
    <name>A0A1B7Y0Z5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154195.1">
        <property type="nucleotide sequence ID" value="XM_018304771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0Z5"/>
    <dbReference type="GeneID" id="28868878"/>
    <dbReference type="KEGG" id="chig:CH63R_09797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09797"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046312">
        <property type="entry name" value="DUF6454"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20055">
        <property type="entry name" value="DUF6454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601259" evidence="2">
        <location>
            <begin position="24"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="416" mass="44243" checksum="CE03662F9293AD72" modified="2016-11-02" version="1">MRFVPSQLVLAGSFLVGTIVAKGTNTMDEGNLTRLRPGVPLAPVPLPPAGPARDGAEILRQLTGLTRAGMNGGGGGGGDGGSRLRFVKKIELEGDVWEPEGIVRLTGPGGNDNDNDDDDDEEEERFWVSAGEYTVPTEKFPDGRWVDGTDRSAGAGFAHFVVFDGRGRRLADWVVSKEGDAEMLTTPGENKYHNGGLDYDGLHIWATLSQYRPNSTATVVRVDPVDLRVERVFRVGDHQGGVVHDVETGTLTTLSWGGRVARRWDLKRGDGGGGDGGREEEQVRLVLGEGVDGGTGFDVPEDVMVNPSHWIDYQDCKSLGRVGGRSLALCSGIATLAPGVEVGGLAVVDVDAGMAPVWEVPFLERTERTTAAEGGGGGVLMTKNPMDVALVGGRVRLYFAPEEGRGAVFVYEICEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y160</accession>
    <name>A0A1B7Y160_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154264.1">
        <property type="nucleotide sequence ID" value="XM_018304840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y160"/>
    <dbReference type="GeneID" id="28868947"/>
    <dbReference type="KEGG" id="chig:CH63R_09866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09866"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="136"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="703" mass="77150" checksum="CED0A986F8BA76A3" modified="2016-11-02" version="1">MAGVLTWRSRFGGVFGNKAENADRTEGEHAGIPKWSMGVLNDPKTIEVPGSVLLLASHRNEPLGLRNAPARTSHSSIPTGFPEPIETPTGSRSPAHAAPPAEVEAKTTKDGIILNPQPEESANDPLNWPAWRRDCALLSLGFYCMVGGGMTPLLAAGFTNVAEDYHIETETVSLTTGLYMMGMGLGSVIFSPTAILYGKRPVYLFSAVIFIASSVWAALSPNFTSLILARIFQGISVSPVECLPSATIAEIFFLHERAFRIGIYTLLLLGGKNLVPLISAVVIQALGWRWVFWVVAMIVALCGVLLFFFVPETFWDRTPLPKSRKPSRRPSFGRRQSSRHQVPQVPADVNAAPADPVPQSPHHHKDLHVGFAPDPGQGARGNDDIEKQAGNISDSPNPAPAIRTSGTSGTPTSGSDYFAKAPAIESEKFPTHSSNVNSPPKALAYTHTLRHQPAKSFTEQLKPWNGRLNHDRWFKVMLRPFVLFAYPAVLWSSAVYALSVGWLIVVSESVALIYRNRESYNFDALQTGLVYLSPFVGGILGTAVAGKVSDIIVKSMARRNGGLYEPEFRLVMAAPVAITTVIGLMGFGWSAEERDHWIVPTVFFGLISFGCTLGSTTSITFCVDSYRQYAGEALVTLNFSKNIFHGLVFSLFVTHWLSDDGPKTVFIWLGVIQLIFLFFSIPMYMYGKRARMWTVRKNFMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y319</accession>
    <name>A0A1B7Y319_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylosidase: arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_10531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154929.1">
        <property type="nucleotide sequence ID" value="XM_018305505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y319"/>
    <dbReference type="GeneID" id="28869612"/>
    <dbReference type="KEGG" id="chig:CH63R_10531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10531"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601279" evidence="7">
        <location>
            <begin position="19"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="350"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="576" mass="63607" checksum="03EAF5515932E457" modified="2016-11-02" version="1">MRLFSLFWLSAITLATQGQSQVNKTFTNPVLPGWNSDPSCTFVKEWDNTFFCTVSSFLAFPGIPVYASKDLVNWKLASNALTRPEQVPELYRNSGQNEGIWASTIRFRDGTFYLITSYVSWYDGWGPKILLFTTTDPYNDASWTGPLHVENPANDIDPDIFWDDGKVFMSVAAGIYISEIDLKTGAATEPIRVWNGTGDRNPEGPHLYRKDDYYYLLIGEGGTETNHSVTIARSREIAGPYEGAPHNPILTAKDTDLYFQTVGHADLFQDASGNWWGIALATRSGPAWEIYPMGRETVLFAVDWKDGEWPFLDVVRGTMTGPLPPVNKDIPGDGHWIDEPDVVDFTPGSGFPRHFFFWRPPKTSLFAISPHGHPNTLEISPSPVNLSATPAFEPKEDGLGFIARKQSATLFNYTVDVSFNPEVEEEEAGISVFLTQAQHIDLGIVNLQACSGTTFIPRFRFRVEASGKPNITVPETVVVPVPKEWRSEPIRLSVSAVSDTEYVFGAAPAARPEEYKEIGSASALIVSGGSGPFTGTVVGAYATNNGGQGKTPAYFSRWRYTPVAQKIEQDTVVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3A7</accession>
    <name>A0A1B7Y3A7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfate permease ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155027.1">
        <property type="nucleotide sequence ID" value="XM_018305603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3A7"/>
    <dbReference type="GeneID" id="28869710"/>
    <dbReference type="KEGG" id="chig:CH63R_10629"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10629"/>
    <dbReference type="OrthoDB" id="3943581at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601292" evidence="2">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="220" mass="23044" checksum="FEEA0C0909545C31" modified="2016-11-02" version="1">MRLSSAPLLRATFVAAWLVSTALAMPQVVDREDPPLSLPKPIATADEGDKARPSNSTAASPSPPSQGEEQQAKPPIPITVRLFPSAPGVKTCRGSPFVDMALPADASRQPTFTTRDGQCYNLPGTAQCGLFAGNKADGCEARLFRGERCTAFSNVAVFQDELRPVGGFFASMSIKCGIVPVEPKPLSLGGLGGKLQKPVQGKRRTTAARGSAPDAGMHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4P9</accession>
    <name>A0A1B7Y4P9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_08457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155454.1">
        <property type="nucleotide sequence ID" value="XM_018303431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4P9"/>
    <dbReference type="GeneID" id="28867538"/>
    <dbReference type="KEGG" id="chig:CH63R_08457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08457"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF39">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR06936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="763" mass="84243" checksum="9B27CCCB467276BA" modified="2016-11-02" version="1">MQQQQQQQQPPPPEPTETPNRGPRLPVNPRRHKVAPEQRKRVATACNSCNIRRIKCSGERPCRQCRSSSRDCQYPTIIEKVSVSRNELDDLRKKLDAAERALLAAVPDHTARRQLLLQQQHDGDASAGSSSRAASCLSFTPPPQHRRKDEFHETAFNVDGEADAADAADADTAEGRQLKDQDGRARFLGETSGATFLDHLKEFMSTVSPLAFNKPWLSPTPNNGSAFLASLGRYQTYDSRPVEAEPDPDPIALPSRADMSAMLADLRHFIQDGNGTFPCGGIYWWGDLGSVPNPVSFPPETPPDAIRHRFRHLAFYHTAFAVACQASTTAASMPVPHDLSQRYFSRARMLLGNPLDITQYTISDVAVLALMGFYLIEMNRRDAAYIYVSNAMHISIMHGAHRGWVDERGKRVFWTLYILDRWLSCLMGRPPTIMDDAIRLPLPCDAPSLPPAAGLRAHVELARISGHIVCNTYRVAPLDHRPGGAARHVDRALQLLENWHASLPAALQMSTARPSTDPACCLLHMAYNQLLILVVRPIFFAAVKKVFAERYITSDRHWDLDHHAPRIAACSDAARQNLFLARWLLNLNGGSRKLLQAGLHYVFNAAIVLMLQDLLIPSFASSSSSSSSSSAESDDVSFAIGVFEAEAKTGSNYGHDCAAVLQDLRSLVQRLRPDAHVVPSTPGLVSADDLTMASGSGSSNTHATTMTAMLTALQQQQHLQQQPTFSLGPSQAYPMDESGPLYQELMTWVDNSDTQLYNSSYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5S8</accession>
    <name>A0A1B7Y5S8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fe-S cluster assembly protein DRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_08874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155871.1">
        <property type="nucleotide sequence ID" value="XM_018303848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5S8"/>
    <dbReference type="GeneID" id="28867955"/>
    <dbReference type="KEGG" id="chig:CH63R_08874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08874"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="13">
        <location>
            <begin position="30"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="12">
        <location>
            <begin position="231"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="333" mass="34699" checksum="2397B1A3C0B2BF0E" modified="2016-11-02" version="1">MAPSVVTLDTTSDFDFTPSSVTTATTTPAKRTLLLAPPSIASHPHKLQTLLASHDRATTDLQMLDRLSAGHVSLPQSAYDLVLVLTDADGSRVESTRLLSARAVLSAVAESLKPSAQLKAQDGGNLANDPTVAREAVLAGLVAAAGSFTKPDYDEDQVVTLSFGRKKASPQSNGAVSLGSKPATAPPVSAPPAGVGFVDFSDDLDMDDDDDDLIDEDTLLTDADLSRPLNIPPECAPKAGKRRRACKDCTCGLAERIAAEDAAARASADKALEAVKLGADDLAEVDFTVQGKVGSCGNCALGDAFRCDGCPYIGLPPFKPGEEVRILNNDIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y717</accession>
    <name>A0A1B7Y717_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane peroxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156293.1">
        <property type="nucleotide sequence ID" value="XM_018304270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y717"/>
    <dbReference type="GeneID" id="28868377"/>
    <dbReference type="KEGG" id="chig:CH63R_09296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09296"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="112"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="502" mass="56453" checksum="BB25D2ACD6AB77A3" modified="2016-11-02" version="1">MDEYMTDHFMTRDDVSDHQQPQPQPPPTVVVDEWPHDSDVSETSPSKKSPSGLRSRITNNLSKKTSIQDRLVEKLLQQVIPESSDGLTGGDDALAPGFPSDKTSAFSQRPNFNITTMSNNFRRFNARIGVMFKFQARVARLLSWRQPTHTLSLLAVYTFVCLDPYLLTVVPLAGFLLAVFIPSFLARHPAPPSGTLSSEQSIGYSPKGPPLAPARTVKPVKELSKDFFRNMRDLQNCMDDFCVAHDGVVSTVLPITNFSNEALSSALFLALTVTTVLMTTFASLLPWRQIALVAGWGLILSGHPAIAPLLTHTHDTHVAPHEARARSRLDAWIADDIILDSAPETREVEIFELQRASHDEWEPWLFSPSPYDPLSQPRIAGDRPRGTRFFEDVLPPDGWVWSEKKWALDLWSREWVEERIITGVEVETEGERWVYDMYDENCAFQGGVGVMDSPTTSKGKSRVAKTPTPSWEEGEDGTGRRGEWRRRRWVRLVKRRATTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y754</accession>
    <name>A0A1B7Y754_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotic recombination protein DMC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156410.1">
        <property type="nucleotide sequence ID" value="XM_018304387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y754"/>
    <dbReference type="GeneID" id="28868494"/>
    <dbReference type="KEGG" id="chig:CH63R_09413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09413"/>
    <dbReference type="OrthoDB" id="5420410at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="366" mass="40516" checksum="254CBA4F9D547AA1" modified="2016-11-02" version="1">MWCQRQHTYLPYLPTTWDMGREGTNHLATLVGVSATDSYSALNTLRAPKRRKKVHARASRRRCERRPYYCINRQTHVKTMADTPQPSGPGGFFPSQTLPSPAPSTASVRSSATLPHPRARSLRPGSNKEETVRRYVEERLAVVNRRYVKKHGNPEPGDQVVGYKTFAELCKDLHGVIDVLWLSGTPSIQIPFLLNIASDFTQWIDSFPPSPRAAFSVLKKLDHCFASLLSGRDIETKATLPGFENGMRAGMSTTDMVRCRSSVEQTRLAVVEVLSREPDDDSKDDETEVDDSETNTTMGNDIGIDDTTGLARDDDDDDDYDDDDSIYMDAARVYEHTIVQLGVKLGDVFGPAAPGASDNTLCSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y834</accession>
    <name>A0A1B7Y834_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156658.1">
        <property type="nucleotide sequence ID" value="XM_018304635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y834"/>
    <dbReference type="GeneID" id="28868742"/>
    <dbReference type="KEGG" id="chig:CH63R_09661"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09661"/>
    <dbReference type="OrthoDB" id="2018906at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="entry name" value="Domain of unknown function DUF1214, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="entry name" value="Domain of unknown function DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160935">
        <property type="entry name" value="VPA0735-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1254" evidence="4">
        <location>
            <begin position="513"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="3">
        <location>
            <begin position="803"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="922" mass="101383" checksum="091E948F020E390A" modified="2016-11-02" version="1">MPHNVPRGGEHKGEEESSPRQTVQSTEEKDGRDWAMAMTHVNLASVGEISASPSSVVGSATRRFDEQLSLRSEPWHTAAYGIDSGQPGYWLPAVELMVHYTTDAYRTFSYSPETTERLRTLVPQLALSSEFLMHELLAFSALHLGHVHLDRRQAYLHQAAWHQDRAVVGLREALVDTLTPENCKAIYASSILVVICAFASLPSGQDGSSIPQAFDRLVNIFPLITGLGAILSASDADSSLPTLIGLFAGSDKNTPGLHHHHHHHHHHGLYELIDRLTRLQGQLANLEPVRETTHQRQEPQGSSATLLESFKDCVLEASRASAILVPAELLAVFLWALRAPRAFPELVRRNHRPALIILAYYSVLLFYASKSFWFLRGWADVVVTTVEERLKGSVWSTLLEWPASVIQLRPLCAVEHPARMVHWRNWAGIRALYYLLLFLIQRNVAPAAASSEVATFLPRELSATTFDAGSPVTLDIDAPVETELEAAAWSIIFTYSMIFNARTMKLLNSSTPVNEFYNVRDFPTVETNSVSAPNLDVLYSYGVLDLSQSDVVLTVPEIEQKRFWSYVVYDLYGNAIGEISNLLGHQAGKYRILRDYDNPVGLSNDNDSNYQGTIRVSTAYATIAARLGILEVTAEDLNTLRSYQDAMALVKVEMTASSAVPSLEKMEIPDSVSGADEQFRLAARLFPFNPPQTISDRERVSGILSQAGLINGTYFPQTGIDLEEASTIANNSVTAASTSLANLVELGKNWTIPKPSFQGNFGTNYDSLVSKSVYYLQTQALAVLPDGLLSGTVSFNTSTSVLITFDSKPSIIGSGFWNIGTYDDNLQLVPNELGRYAIGSNSPDIQYVNGGQVYGSNATLGDGAFQILLQVANLPPPANWTGNWLPVAESGQVTFRVYGPAEAMKDGSYSYPTVEWIPAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y892</accession>
    <name>A0A1B7Y892_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CVNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156742.1">
        <property type="nucleotide sequence ID" value="XM_018301964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y892"/>
    <dbReference type="GeneID" id="28866071"/>
    <dbReference type="KEGG" id="chig:CH63R_06989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06989"/>
    <dbReference type="OrthoDB" id="4672515at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601416" evidence="1">
        <location>
            <begin position="26"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="199" mass="22020" checksum="71622BA9EEFAB29B" modified="2016-11-02" version="1">MIKFSLPMPFRGLLLALGAAQVIQAGFLDDGCGFINEGSQFTLRGDGSITTYCNDKFCSTVGFTVLNLNDCITNVVGDLRPKADGERGNFWKSCKDCYIEGSHIKCQCSRLDGSFKESSLDVNSIVFNWNGYLACHSQISNCYPMTWQCMPDNWWPEGWRPTVVDTPCDIWQAATMTPPNLTLPPGLKLASNLLPGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8B1</accession>
    <name>A0A1B7Y8B1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_06985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156738.1">
        <property type="nucleotide sequence ID" value="XM_018301960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8B1"/>
    <dbReference type="GeneID" id="28866067"/>
    <dbReference type="KEGG" id="chig:CH63R_06985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06985"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="825"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="78"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="501"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="884" mass="99435" checksum="94D525A77E302DAD" modified="2016-11-02" version="1">MGIGGYFKSEKPEASGGGSPPQPSRSNTASMMEKGPSVRTSTNDMELQPPTPRYNSRPQSVSGRSTHSNGSSMFLDDIKHEVMVNYLYQQQCSHLWVSDGSGEIEGVLLRKARGQYMACPPQLGNSPFAEACAALNVQCSMTVNSRVIKTFLQWSPDAVDVPLMNGLRVQILPTIEDLPRARKHQFAAFIAAEGLLVVWDDDALHLVQRAKAIESELMELVWKAGADEDEGDEKKGPNVADYEIDEESGEIKPEKRPVHLLNTYLVSITLVLVVVSLGAAWRQLAIEVSVDGEYLRLALVALFPLQIFFTLFFAQVIVGCLAQIFGPIRQLTINSKFYSARPPPRLQSAVLPHVTVQCPVYKEGLAGVIVPTVKSIKQAMSTYELQGGSANMFMNDDGLQLISEEERRARIEFYADNSIGWVARPKHGENGFTRKGKFKKASNMNFGLMISLKVEEKLQAISRPVEWTQHDEAQAYEHALKEVLEEDGRAWADGNIRVGDYILIIDSDTQVPADCFLDAVSEMEQSPDVGIMQFSSGVMQVVHTYFENGITFFTNLIYSAIRYTVSNGDVAPFVGHNAILRWSAIQQVGYFDEDGYEKFWSESHVSEDFDMSLRLQCNGYIIRLAAWAGEGFKEGVSLTVYDELARWEKYAYGCNELLFHPIRTWLWRGPFTPLFRKFLFSNIRFTSKITVVSYIGTYYAIGAAWIMTSVNYFLMGWYNGYLDKYYVDSWQVWFSIIIVFNGLGNVALAIMRYRVGEKSLLWAFFENIKWTFLLAIFLGGLSLHVSQALLAHMFEIDMSWGSTSKEAEFSNFFIEVPKVLKKFKFSMIFSCVFIAGMIILAVAPFIPHDWRITDFVAILPMATVSASHLLLPIALNPALMTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8C3</accession>
    <name>A0A1B7Y8C3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156790.1">
        <property type="nucleotide sequence ID" value="XM_018302012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8C3"/>
    <dbReference type="GeneID" id="28866119"/>
    <dbReference type="KEGG" id="chig:CH63R_07037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07037"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="495" mass="55681" checksum="2FB3AC18AF161501" modified="2016-11-02" version="1">MTDGNHIPQAPSFIGLPIEIQTQILQQLVSSHHESIPAVLRTCKHLYRVASPMSVHTYENATSKNMSEHARKRSRNLDFLRHITIAKPELAHNVRRISIIHVSTSLIYRLAPANKRPLGPSSDEMAVYTDLIDASGLSDHIDDWEAVRKEWLQGLADGLVEQQVGLLLLACPRVESLKLGTPLSPRLLPRLIRAAAANRATSPPAIGPAPGAGRPLLDGLREYFGEPESPKSLFHFFNIGKEFMQLPRLESFTCACLSNSGPNGHLFDEEANPPGCSNVQHLSLLDANVTIEGLRSLIRACKGLKSFHWTPGDSTFSDMQIKLPELAQALSTQSDTLQHLHIDYQDRWRGADWYAKREGFFIGTSLKEMASLKSLRIGMEAFLGFTDMWRMPDGDLTHEQWSEFDKTPRLIDHLPPSLECLELHGCREEVIPHVQEVLDRLRSGERVAMLRRIRLCFNPYLVDHRSVSFVCDGRPVDFDYAFRCPAVEKDMLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8R0</accession>
    <name>A0A1B7Y8R0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156912.1">
        <property type="nucleotide sequence ID" value="XM_018302134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8R0"/>
    <dbReference type="GeneID" id="28866241"/>
    <dbReference type="KEGG" id="chig:CH63R_07159"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07159"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="215" mass="23513" checksum="4A5661894ABF5B07" modified="2016-11-02" version="1">MTETVLVFGASGNVGVAAIIGALSANRHVIAVVRNQSSAEKMFKQVGRRESITVVEADITSEDSVKSIVDQVRRGILPSFQHVWASLAYRATVPYLLEQGFAGSTWTMCTGGSGDTGYRVAPAVTQGALFSFAVAAARDNDKTNIRFNEVYLAYRVQFEVETGNQTFAGIHMTTSKDFAPLYEKLLDRADIRSSRVKALSPEDVLKLSYEKKFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAS3</accession>
    <name>A0A1B7YAS3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_07829</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157581.1">
        <property type="nucleotide sequence ID" value="XM_018302803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAS3"/>
    <dbReference type="GeneID" id="28866910"/>
    <dbReference type="KEGG" id="chig:CH63R_07829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07829"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR09064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25547" checksum="52F6D702EB8004CC" modified="2016-11-02" version="1">MIKMNTRAIKISAPTKLGLGPRLHPLLLQRSYATQTGLGATSAPGPKRKTITPFNDNGSIPWSQLSTGEKAARATQQSFNFGLILAGLAGGVVYVLWSDVISPDSKTAHFNRVVDRIKNDPKCIEMLGDPKKISAHGEETNNKWRRARPIASTINTDSRGHEHLLVHFHVEGPLNKGVVYLHMVKTPSSGEFEYKYLYLDVRGHQRYYLENADTATGIGKKGVRFLGINWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAU5</accession>
    <name>A0A1B7YAU5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157517.1">
        <property type="nucleotide sequence ID" value="XM_018302739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAU5"/>
    <dbReference type="GeneID" id="28866846"/>
    <dbReference type="KEGG" id="chig:CH63R_07765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07765"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="67" mass="7721" checksum="ECF737AEC6407E96" modified="2016-11-02" version="1">MTERLGGLESRDEINVTEMLGSPEAAPQGWLRKRKVKVYDKLQEQWRVVERLWGDSIGPNVSQISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD36</accession>
    <name>A0A1B7YD36_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_05624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158449.1">
        <property type="nucleotide sequence ID" value="XM_018300599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD36"/>
    <dbReference type="GeneID" id="28864706"/>
    <dbReference type="KEGG" id="chig:CH63R_05624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05624"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR09932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="732" mass="80381" checksum="A045B56FA6A7BD0E" modified="2016-11-02" version="1">MTPASSPLRYRKNGRLQACDPCRRRKVACDHVSPVCSNCKRRRQAEPCEYTVSTPARMRSARAASSAQTTTSPSASVTGSETVAEQQHEHATASTLVEQHDQHPRTSPLARDKETPTPGGPAREMGVRDTLSGHLGFTSWSDVYREVGNGLSGHDLQHPEGGSPTDQANDQSLESRKDAGAASAEDAKTLEMCLSVLRQVPQEYEGRALFDPYADPRNAFIHPISQRAQDSLYATFGRHLGPERDDARLSELARVLCRNSARPFSEHEPDPEVWMAQFMGPNLRWEMLGILFVSWEIKARTRDLARTEVGRMGYGQKNEFRKCILDCLALARRAAEVGNTLLLYLYIRKTVIESIVNGDTSLSTWMSSGEMVSLLTFLGLHAEQTKQPYRPTLASELRRRLLLKAFSLDKGISTITGRPPSLSHRYVLTPLPLDIADDVLMVRDGGGAAAAAALDAGGWSPDGRLYPVTMWRARYRFMRIRDEIFEVALGPEAAISADAVRALKVKELVAAAELPAVLRFSESDVQDPGVSSRVLDTRLFMLLEHLQNLFFIERLLSRFDRAGRGELLAVSYNMTSATLLYWTNMDGLGACEDFKWIAMTYAAPGGGILCQELLQPTVTGGSHAAVTDRNGNPITRSGIVQVLSLLLGFLKWVSPREASGGICAGCRDIVQRVLDEALNGNVGPGGGAGGGEHAVGGVGWDSEVQLDFNFELLDTFEWMRPEFSWGDASQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD45</accession>
    <name>A0A1B7YD45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158482.1">
        <property type="nucleotide sequence ID" value="XM_018300632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD45"/>
    <dbReference type="GeneID" id="28864739"/>
    <dbReference type="KEGG" id="chig:CH63R_05657"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05657"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="178" mass="20267" checksum="F35F7577F96F38E7" modified="2016-11-02" version="1">MGRAPTASSGGFKINRDLRLIDYYTDFLYKMTKPDEPRHPQFEIYGSSVTIWDVWGKSLYFSLQRILRLPKRRQNLWHVNLPSFTTYPSTSPILELEVPLKHVTVGWLERTAGTMGKEVGFESLTTPPSGSSLAAGTFPSQRTCEKACEQIWDWSRKRVLNIQILSTVVFRSITGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDB9</accession>
    <name>A0A1B7YDB9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ring-8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158562.1">
        <property type="nucleotide sequence ID" value="XM_018300712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDB9"/>
    <dbReference type="GeneID" id="28864819"/>
    <dbReference type="KEGG" id="chig:CH63R_05737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05737"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="50310" checksum="470C33DBC1351356" modified="2016-11-02" version="1">MAVIDQVLVEVSRFVVRQVSESASSLPAPSTTAPTSTFSETAPTTTVTDNPSPTSNPGNGGGGGGGGGGSSNSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARNRAMRLNEDGEPINLENMPRPHRRRREKKLMTMDEVNDKFPMTKYKTWVGERAREGLPTAGGVSAPPSRANSLRSVDGIVPELPSKERESTEDRPATGASNKPVTSEKTTEDAVKKEGNTSTTTGNADAPQSTPTSATPLQRVNSEDDDDEDDEHINAAVPPELMATSGDTCAICIDTLEDDDDIRGLTCGHAFHAVCVDPWLTSRRACCPLCKADYYTPKPRPAPGEGDPNATGDMARTASRANMPNAPPAAWYSLSGNRLGFGRNRGNRTANTRSDRRRRARQQAVSASSTQNASQGSPASPPVVENQESRGLLANIRLPAFRNPLRRGGDQQPGSPTTAAGANVTPSQLEAGTQTAPATTTTEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEC0</accession>
    <name>A0A1B7YEC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Memo-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158899.1">
        <property type="nucleotide sequence ID" value="XM_018301049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEC0"/>
    <dbReference type="GeneID" id="28865156"/>
    <dbReference type="KEGG" id="chig:CH63R_06074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06074"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="322" mass="35536" checksum="2E230C360E7D1D6A" modified="2016-11-02" version="1">MAPSRDTRQPGKQGEWYLGDAKKLREQLDGFLADVPDQIDGNALPVPGARVIIAPHAGYTYSGATAAWAYKALDLSKAKRVFLLGPSHTFYLADCAVTGYSNYGTPWGNLRVDRQVVDRLRDELDIPKIPTANDDREHSLEMHLPYLWVRLEQTFGASPDAFPPVVPILIGDNDEAGEKAVGKWLAEYLRDPDNAFIVSSDFCHWGRHFDYTVYSPDGTLDSLRKLRPVGPAPEGPPIHETIKLVDDLAIEAIGTGRHGSFYNNLKQTKNTVCGRHPIGVTMAALEELGGGHRFKFIQYQRSNLVTVPGDTSVSYVSAYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFQ7</accession>
    <name>A0A1B7YFQ7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159362.1">
        <property type="nucleotide sequence ID" value="XM_018301512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFQ7"/>
    <dbReference type="GeneID" id="28865619"/>
    <dbReference type="KEGG" id="chig:CH63R_06537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06537"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF4">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="38556" checksum="4BA462C6C1A496E3" modified="2016-11-02" version="1">MASRRGTILLTGANGSLGNAIVSKILSSPDLATSYHGLYTVRRVDRATALDSLLLRNASTQQQQHAHETVALDLSRLESVREVARSINERVAAGLLPPLRAIILNAAYQEHTTQDFSPDGFDMTFQCNYLSHWLLVLLLLQSLDKEHGRVVVLGSWSHDPLDSRNDSMGAYKEDQWKTIFHDADSLAKGTWSPTKDYPTMEGGFRRYGAGKLCEIMMMYELQRRLDADTALSNITVLGVDPGGMASGLTRRGSPVLVFFVRWAFPLLAAVMTWFSPNGILRPVSKSAADVLRAAFDTAQLGERPKAVYLNGSEIGDTSAEAKDPVKTKQLWEASVGYTALKPGDTILSGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG00</accession>
    <name>A0A1B7YG00_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159618.1">
        <property type="nucleotide sequence ID" value="XM_018301768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG00"/>
    <dbReference type="GeneID" id="28865875"/>
    <dbReference type="KEGG" id="chig:CH63R_06793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06793"/>
    <dbReference type="OrthoDB" id="4848599at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="175" mass="17989" checksum="DCDA1698861D5639" modified="2016-11-02" version="1">MSAPIPRPSSTTTGSSDSMASTASQQFTGSMDSYALSMYEHTRSLMAAAHIPYGSPASLLLATSPGSPGAPAVAGTSSGGASRMKAARLPVPLVPLLPTETFRRNRNNKSPVCLETASYTTLLSAWPLALVDGVASAARRDKTHPCGALKGADNRHDLCCPSRCSASEAPIAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG16</accession>
    <name>A0A1B7YG16_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159407.1">
        <property type="nucleotide sequence ID" value="XM_018301557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG16"/>
    <dbReference type="GeneID" id="28865664"/>
    <dbReference type="KEGG" id="chig:CH63R_06582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06582"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="105" mass="11661" checksum="244BD1D22770FEFD" modified="2016-11-02" version="1">MQHIAKEGRCFVVSVNSVCKVSDFPADYPPFTAEDPDRRPDGEQWEADDIVNHGGSCIVGPLGTFLAEPVWDKETIIYADLRMADLTESKLDFDPVGSYSRPDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG35</accession>
    <name>A0A1B7YG35_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_06536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159361.1">
        <property type="nucleotide sequence ID" value="XM_018301511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG35"/>
    <dbReference type="GeneID" id="28865618"/>
    <dbReference type="KEGG" id="chig:CH63R_06536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06536"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="609" mass="67969" checksum="A2777B3637187CC1" modified="2016-11-02" version="1">MSSQEAAPLVALGASAGLWQAALTLLVTLVVGYLAKTSLSSNSLSKIPLVGLEIGDEEKRRLAYLGGAKNIYQQGYQKFKDGIFQITTSRTVPVVIVHPRFLNELSKLPPQILSADAAVNEGMEAKYTQLWTIPVVPHAIKTMLTPGLGKSHHSWFLFFVFFCKKANIHVIQVRLTEIVAEELQEAFSRELPDCKDWSSVQVHPTLLRIVAAGAGRVFVGPELCRDEKYLDSSINFTGDVMTARNAVQQMRQWLRPFLAHRLPEVQRLSQHRAEAEEFLRPVILKRRKMMADPDQERPDDLLSWLMEAQATSGKGSDRDLAEQQLGIGFAAIHTTTLTGTNAFYNLAAMPDVAAELRDEVSTVLAENKGAFTTKALHEMKKLDSFLKETLRCHPFVFGEIQTRSPIYLSAWLVGKKEGKKRNNLANFLIPFEARLADTTTLEPIATFQRKALKDITLSNGQVIPAGTTIECPNYAVSHDEALFEDADEFDAFRFYKLREKAALERTPDQTSDASMQNQFASVSQNSLAFGYGREACPGRFFSANELKVIFSIALLQYEMKLAEGSEGRYPNMEFGQLASSPRSPSLPVHAFDSMRLSRLSTLLTRVMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHC7</accession>
    <name>A0A1B7YHC7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_03847</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160068.1">
        <property type="nucleotide sequence ID" value="XM_018298822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHC7"/>
    <dbReference type="GeneID" id="28862929"/>
    <dbReference type="KEGG" id="chig:CH63R_03847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03847"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601664" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="419"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="519" mass="57864" checksum="A3DECB53582DD3D0" modified="2016-11-02" version="1">MRREGNLKASAVLLCLATACVSVHAQQWDWGELGTCHRPLPADLFAMRSAHLLPASLAGLGLSRTAAALVSRDGVTGRLPALGWNSWNEYGCDINETVFLTVAQHMVDYGLKDLGYEYVNIDDCWSDKVLRRDNATKEIVVDAVKFPRGIKYVADRIHAMGLKVGIYSDAGTSTCGGFEGSLGYEEIDAATFAKWDLKYDNCNVPKEWFDDWKYVPELWLGGPPNENQDNGDPVNSKTGKPAPAGYDWSTSVTAERYRLMRDALLAQERTIQYSLCAWGHAHVEAWGNETGHSWRMWGDIYPEWYGQHQWSWGLMPILNHAAFWSGPDVNGFWGHGDWDMLEVGNGNLTYEESRSHFAFWAALKSPLIIGTKLEGIRPEILAILANRELVAFNQDPVFAGAAQPYKWGINPDGAWNLTHPAEFWAGESVKGTHVFVLNTLAGTEEKAIAFADVPGLEAGKRYAVHDMWTGEDLGVFEGEVRVELKSHDTAALRINEVKCVPRPARARRRTGFSEWDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHN3</accession>
    <name>A0A1B7YHN3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH63R_03634</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159855.1">
        <property type="nucleotide sequence ID" value="XM_018298609.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862716"/>
    <dbReference type="KEGG" id="chig:CH63R_03634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03634"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1010"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="120"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1085"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1129"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1099"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2221" mass="246174" checksum="8528F2ED00FF536E" modified="2016-11-02" version="1">MDNEITPAPPVGVTASNQFNRHDTTTAAGSAAIQKLNNEDNVPGSPFAFSPTQLCELIENRNPNSLNAFGGLTGLASGLLADINAGLGVDENIIDGAISNSDLCRGNLNMSNRSQTDSKPFTKLTSAAGSFTDRRRIYGENRVPGRKPKTFLQLLWMAFNDKLMFLLTASATVSLALGIYQSVADAGQGTSIEWVEGVAIIVAVAVIVLATAINDYQKNSKFQKLNQKKEERTITAIRSGRHRPISIFDILVGDVLHLEAGEVAPADGVLVQGFGIQCDESALTGESDLVAKSPVTHDARTTIDPFILGGTKITAGVGKYLVLAVGVNSSYGRIMMSLRDDIQETPLQQKLGILAKYIITFGLAAGAIFFTIMFVRFLVDLNSIQGGPKEKGHAFLEVLILSITVVVIAVPEGLPLTVTLALAFATTRMLKDNNLVRLLRSCEIMGNATTVCSDKTGTLTTNQIGVVTGILGSSSAFHDVHLAPAAIDDDAASPSTAETFRVLPSEVKELLKTAFVLNSTAIETSERSRFVGSSTETALLKFALDHLGLGSLDEERANGNIVQVIPFDASRKWMAVIVKLGDGRHRMLVKGAAEVVLARCTEIVRDPTTSNDAVEITPDQIQTLDKKILSYARRSLRVVSIAYRDFDDWPLQESPQLNSLPGLVFFGAFGMRDPLRPEVIESVRHCQSAGVFVRMVTGDNFFTAIAIASECGIYTAGGIAMDGPTFRKLSPTQLDLVVPRLQVLARSSPDDKLRLVSHLKSLDEIVAVTGDGTNDALALKAADVGFSMGISGTEVAKEASAIVLMDDNFASIAKAISWGRAVNDAAKKFLQFQFTINVSAGILTVISALVGGTESSVFSVVQLLWINLIMDTFAALALGTDFPTPDLLKRRPEPRGISVLNTTMWKMILGQSLYQLAVIFTLHYAGERILQYHTERQLLELQTMIFNTYVWMQFFNQINCRRVDNRFNVLEGVQQNPWFMLVQSVTLAGQIIIIFFGGEAFHVVPLTATQWGWSILFGVLTIPVGIGIRLIPDWILFKSWGFCFFFLSRFKRHRSRETQNAGHGLLSYLQLARPFVRLGPYGKLQPVSHEPSGGRKPATPSQRPPKNNSPLSIIVLLWLNLSAQSHQMERVDESKGCDGKRSRRNQSHDSAPLDTKRRRTQGASSDYDRCRVQNVSSRRFPHTEYTVGWICALPIELAASQAMLDRTHESLPTKENDDNTYTLGNIGHHNVVMACLPLGQYGTNNAAIVASNMHRSFPSIRIRLMVGIGGGVPGHVDIRLGDIVVGNRVIQYDMGKMLSGGRIQRTGVPKEPPSALLKAIAQLQAHHERTASQVPAILAKIFERYPSLSRFAYPSALEDRLFRATYEHGQQPDCHQCDLSELQDRPERTSRDPKVCYGGIASGNQVVKSARYRDALAKELDIICFEMEAAGLMDIFPCLVIRGICDYADSHKNKQWQPYAAATAAAFAKEFLSVIATSAAAMTPAVVQDSRATETPTPTPHENESCLHDRRGEVLDLLRFDQLDARHATIKAAHRQTCSWLLEHDSYKDWLDPSKAAQHRGFLWISGKPGAGKSTLMKFAYGNVRRRSEANTCHISFFFNARGDELEKSTIGLHRSLLLQVMERFPDLQSVLDDPVLIPHHLSVCPTTEVLRELFRNAVMGLGQRRLVCFVDALDECNEEQVREMVTYFEDLGDEATNDGIHLQICFSSRHYPHIEIENGLRLTLEDQPGHEKDLEKYVRSCLRVDTRSDAEEIKNGVLKKANGVFMWVVLVVDILNKEYARGRIFAARRKLDEILSRMSELSKDIVRRDNDHMEDLLLCIQWILYAKWPLTREEFYFGMLCRSPEDLSVFDPDMITNSDLDLAVVRSSKGLAEITKSKVGTVQFIHESVRDFFIKDNGLQEIWPEIGEKFQSTGHEKLKQCCHAYINFGTTSHVDITESLSKANSPEAKELRQIISKELPFAEYATKHVLYHANAAATEIFQHDFLKGFSLREWIHLNNLFEKHEIRRYTPNANLVYILAEKNLIKLIETFVRDHHNVHVMGERYQLPMFAALSNGHLLAAKALLGQAAKSYRQEDLFSNIRSKKDRIIRRDQTPLHWAIENRHVALATIMIADKDIDLSLVDRNRRTALHLASALGDDAAVVVLVESLIDLHAERLNKALASAMDTTQTDQSTTAKASVDKFAYINRKDIGGRSPLSYAAADGSKHVVRSILTRVLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ18</accession>
    <name>A0A1B7YJ18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RWD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160391.1">
        <property type="nucleotide sequence ID" value="XM_018299145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ18"/>
    <dbReference type="GeneID" id="28863252"/>
    <dbReference type="KEGG" id="chig:CH63R_04170"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04170"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="275" mass="29804" checksum="07E801C0667F36C8" modified="2016-11-02" version="1">MSDDLKDEIEALNSIYGDDTLRPSPPNYILVLPGGPGATSLTIHFSDSYPDVPPEVLGTHSAGENAPRGAGARDLAIFREAVAAVYQPGAVCLFDAVEEFSRLLEVHADTEPSAPSPSLREEAEHETQPAPSFLSEEPPWIASEPFVELKSVFLARAAPVTSPEQAAGYVQHLLATDKKVRTATHNMTAWRIRGPNGTSFQDCDDDGETAAGSRLLHLMQLMDLWDVMVVVSRWYGGQKLGPRRFALINSAARDAFVKAGWVEEAGQGKKKGHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKS6</accession>
    <name>A0A1B7YKS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf1237 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161167.1">
        <property type="nucleotide sequence ID" value="XM_018299921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKS6"/>
    <dbReference type="GeneID" id="28864028"/>
    <dbReference type="KEGG" id="chig:CH63R_04946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04946"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601738" evidence="1">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="534" mass="59509" checksum="12CA452E91EC7BA9" modified="2016-11-02" version="1">MPLRSVADLLLSVGLFVGQVYATQEPLTGDDRAACPNYAQYSTYPHKPLSEGPLALPYQRPDPRCRTFQSDAIEKVIKDVTSRMKDPDLARLFENAFPSTTDTTVKFHTDGTDTRFVDLNGRSLRDEGKWEGPQSFIITGDIIAEWLRDSTNQLSPYQSLAKKDPAIFKLILGAINTQAEYVIESPYCNAFQPPPIANLQPSHNGQDDTVHPIYEPSFVFECKYELDSLAHFLALGNDFYEHTESKDFLTGRWYLALDTLLNVLEEQSRSTFDPETGRFLKNEYTFQRKTDAGTETLNLKGVGNPLNNGTGLVRSAFRPSDDATILGFFIPANAMMAVELKRTAAILKEAGKDVLSQTVDKWSQTITDGVWNNGVVKHAKHGDVFAYEVDGYGSSILMDDANYPSLLALPLMGFLPPDDQIYQNTRKMLLEKTGNPYYLEGSAFHGIGGPHIGLSNAWPMSLLIQAQTSEDDKEITECLDLVLRSARLGLVHESVDVNRISSFTRANGVFAETILDLARRKPHLIFTDGKPYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKT9</accession>
    <name>A0A1B7YKT9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161178.1">
        <property type="nucleotide sequence ID" value="XM_018299932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKT9"/>
    <dbReference type="GeneID" id="28864039"/>
    <dbReference type="KEGG" id="chig:CH63R_04957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04957"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447776" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="58320" checksum="ADEB1870EC953091" modified="2016-11-02" version="1">MKNSVIVSILSFLFSTVVHAALPPSAVVGAGTVVGTTTTLPSSTALVNKFLGIPYAQPPVGDQRFLPPQSLKSFVETPLNATVWSSKCLQYKIIDDGIAESEDCLFLNVFAPAAVGCSSSGRPVLVWIHGGWLREGTASQPMFDGSSFASQQGIVVVTFNYRLNVFGFPNSEQLPLGAQNLGFLDQRLALEWVQANIHAFGGDPAKVTIAGESSGGSSVDRLVTTMHTNQSFRAAALSSGQATVSAIGRDAGPLSWAALVSILGCSGEDETACVRGVDASTVQKVVSDHGLDFSPANDNFTQMELPYLPARAAGDLAPVPILIGSTGQEGTYLAPAYNLDIPNFTEPVLVQFLNGLTGGDSESVGGMLQVIQLVQQTSGISLFHAAAQVYTEIVYQCRPPYSVAPLITDTLKPNLLISQTSAQSGIPTWRYYYNASFPNLAAGGYTSEQLGASHGSDTRMIWGTYPREGATDRQISLSRYLQTIWAGFVKDPLRNGPGWEKVGVDGNNIACIGCVGSETMTLIDSATVDGRCAFYAPFFDKVKTPFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLC1</accession>
    <name>A0A1B7YLC1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161360.1">
        <property type="nucleotide sequence ID" value="XM_018300114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLC1"/>
    <dbReference type="GeneID" id="28864221"/>
    <dbReference type="KEGG" id="chig:CH63R_05139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05139"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601776" evidence="4">
        <location>
            <begin position="22"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="497"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="649" mass="70823" checksum="9AEC1CC5653A2156" modified="2016-11-02" version="1">MRLITALSTGVCILGVVVVEALPRRAHTFVKRQVTELREEYDFVVVGGGTSGLTIADRVSAAFPEKNVLVIEYGKIEGTVGYYDPPEDGRGASRLVISSPPVASVNNRAATVLLGMTVGGGSAINGQFLDRGSRYDYDEWARLGSPQFDDSPDSWDWENFGPAFKKANPRRIRHANAEIHQSFFLTEPNDELVEKYGYTWNASAYTGDAIEASFPPFQWPAQRFGWRAFEEFGLDAPASCDDGDKHGICWVPTAQNSETVERSHAGVGHYTRIAETRPNLDLLVEHKVTRLVVDKDKTSVPAVEFRPVAPGGEVRTIRPKHEVILSAGAVHTPQILQRSGIASSAYLESEGIELVEDLPGVGQNFQDHCGVPVAYSYDTPRPSEADVANNATYAAEAVAQFRERPARGPYTLAMGNSAAYVALRHVTPEWERIVADIRAQIGDRSVLRYLPAGAAEPVREGYMAQLEIIAQALEHPEHPILEMPFQAEPGTGFLLKPLSRGSVVLNSTDHDATPVVNYATGANPVDLEIMAAYVDYFRRLYSTDTWQGLGAVEVAPGAHVTDHDALIEYVKDNVIQSLMHPCCTAAMLPREKGGVVDSSLSVYGIPGLRVADCSIIPTIPAAHTTTTAYAIGEKAAEIIIRRWKKKCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLJ5</accession>
    <name>A0A1B7YLJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161285.1">
        <property type="nucleotide sequence ID" value="XM_018300039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLJ5"/>
    <dbReference type="GeneID" id="28864146"/>
    <dbReference type="KEGG" id="chig:CH63R_05064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05064"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="884"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1041" mass="117758" checksum="159E184FB06D3A30" modified="2016-11-02" version="1">MADKYAAQDLSDAALGGPIGLKDGYFIDGHGRTLTLHGLNVSGASKLPTEPNGLSHLTDGFFEHRTVTFVGRPFPLQDAPLHFRRLRAWGLPLVRLLVTWESLGHAGPDPETDLDFEYIDYLRQLIELMPKYGIKCFVCAHQDVWSRFSGGSGAPGWTFEVAGLDVEAFTDTGAAYVHGQDELRRANAPVNEKEPSGPFVWPSGYQKLAASTMATLFWAGDALAPNLRCPRPQSSAKGDTVSVREYLQHAFVEAFGRLADEVSGLEACVGFEPLNEPHRGLINLHGFDGWNYDTDLHIGYYPSLTQALALASGYAQEVDYYVKSWPFPTRVSHRTLVDPKGRSAWLTAKPDAAKPQNYGLGECVWRAHGVWEWDETKKGPKVLQKNYFEVDHRPGSEGKPIEWYRDFYGPFLKRFSDRVSRKSPRQFCFFEPIPNEFMPPWIGQGDKADESAQKQTYATKTIIDTQRPGNLVFAPHFYDLNVLFSKHHSWMSVNVQGASRGMFILKALYFGAKALRKNYRLQLSNILKYGKKSLGGHVPALIGEVGISFDINGGAAFKTGDYDKQRELMHALISAMEDNQVAFTLWNYNPDNRVEHGDGWNMEDFSVVNGNTEARPGHILPDYANEAHEEDEMYRGGRVLDVIIRPYAVKVAGRPLRSDWDSRTLHYEFEWVTETPDADHTGKKKSDKSRTTEVFVPNYHYAGRGIQVKVSGGEWSYDPDLQTLYVHHDASRTDHRLTIDIPNVPKHLMETVERRRRAFPPRFPLSLVSPSTELAMEELMLTYLRIIIREFGIFSQSGSTREEKPIFDKDQHNTSHLPNHRLSKLGKMMMGYDDDDGQGSRLFEHRASDPHRLVPRSELVVYDPRKQVFGLQMYSWQIKRVVPDPGSLVVYIDGACRDNGARAARGSWGVYFGPGSQYNRCGLLAPDLPQTSSRAEIEALAQALDALHEITRRDYSLRHITIATDSEYLAHAMSLWIGDWIENEGMTARGRRVAHFETLKALHERLDEMTYGDDGGLDFMFWPIPREENTEADRLANQAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMD5</accession>
    <name>A0A1B7YMD5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ACC synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_01929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161720.1">
        <property type="nucleotide sequence ID" value="XM_018296904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMD5"/>
    <dbReference type="GeneID" id="28861011"/>
    <dbReference type="KEGG" id="chig:CH63R_01929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01929"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="41"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="430" mass="47550" checksum="F80B704ABC692B8E" modified="2016-11-02" version="1">MTYGLSNRGNVAAKPDDGMLLWTIVKDLWDPKDNPRGYVSLGIAENTLMHDKLSAHIHANLAVPNHSFTYGDGMTGSKRLKASLARFLTERLKPTTGLEPRHISVTNGCSSAIEHLAWALGNPGEGFLLGQPHYGAFFPDVEYRTGCKLVQVPFHEVDPFGLGAVRKYEDALLAAQARGTRIAALILCHPHNPLGRCYPRETIVGLMRLCQEHDMHLISDEIYALSVWDNTLDTDPAPVPFESCLSIDTAGVMDPHRLHVLWGMSKDFGANGIRLGAIVSQHNPALHDSLTPVGIYSSPSSITDHATANILDDREWVDGYIEENRRKLQENFELVAGWARDRGIEYAQGANAAFFLWVNLGEAYRARRPEREVGDVTAEVMGALLEKKVFLASGKLFGSEQPGWFRIVFSNEKEVVSEGLRRIAAVLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMH3</accession>
    <name>A0A1B7YMH3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161649.1">
        <property type="nucleotide sequence ID" value="XM_018296833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMH3"/>
    <dbReference type="GeneID" id="28860940"/>
    <dbReference type="KEGG" id="chig:CH63R_01858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01858"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="12999" checksum="E2120D19D4879BA7" modified="2016-11-02" version="1">MLSPQYRGMVPVIGKSINAKPATSPLANYGRFGTHGGRHGGRPGPVPDPWRPTLLSDNDYPRPFPCMSRTVRWVAQMHAKDTTALRLRYTLDVVYLLSVPGWRSQSLISTPKDPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNP1</accession>
    <name>A0A1B7YNP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U1 small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162193.1">
        <property type="nucleotide sequence ID" value="XM_018297377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNP1"/>
    <dbReference type="GeneID" id="28861484"/>
    <dbReference type="KEGG" id="chig:CH63R_02402"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02402"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="45870" checksum="16BC6636C8D1309E" modified="2016-11-02" version="1">MTDKLPPNLLALFAPRPPLRWVAPPDHAPESRRTLPVSGVAEFLPALQHYKETDDYKPTESWLQMRDRKKLEKQAAVESLKTEGPKNFKPHEDPNIRGDAFKTLIVARLSYEANEQDLEREFGRFGPIERIRIITDTHAHEKPRKKKKPHRGYAFVVFEREKDMRAALDACDGIRIKDRRIKVDVERGRTVKGWVPRRFGGGLGGRGYTKALPARPMGGGPGGNFGGGGGFRGGFRGGFEGGRGGRGGFRGGGFGGRGGFRGGGDFAPRGGDRGPNGYGAPRDAPSGPGRGFGGDRGDRGDRSFSGGGYDRGGGRSFDDRSGGAGDRGDRGGGYRDGGRFGDRSDRDRDGGRRTGSNMEPIRPRGEGGYRGDRGDREDRDRGGRDRDRDYDRPRDDDSRKRGYEGGGYEDPRKLRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ05</accession>
    <name>A0A1B7YQ05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162642.1">
        <property type="nucleotide sequence ID" value="XM_018297826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ05"/>
    <dbReference type="GeneID" id="28861933"/>
    <dbReference type="KEGG" id="chig:CH63R_02851"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02851"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="687" mass="75573" checksum="64BD9562E1E74938" modified="2016-11-02" version="1">MADATEYTAAPTPMEVVDEQSPGLSTPASKTKGRHRVLCGVQRMSSSPSLSRSGRMRSHSNPQRGRGNVSCVSLAGPSTSGTSFSGDSYFPTGATASGYASASSSVPGTPSSEVIQFVGIDGRLAIRRVDNVFPTSQSPGPQTIGLPSDLRTTSKPQVANPTIPKRGFNFWENMPHEMRVHVFSYLTPKELVRASRVSKAFHKICFDGQLWTSFDATEFYQIIPAESLARIIVAAGPFIKDLNLRGCVQVEHYKRAEVVVKACKNLVNATLEGCRNFQRNTLHSLLRSNDKLANLNLTGLTAVTNMSCKIIAESCPQLEMFNVSWCVHMDARGIKAVLEGCPRLKDLRAGEVRGFDNLEVADTIYKTNNLERLVLNGCAELNDRALKIMVHGEDPEIDILTDRPVVPPRKWRHLDLSRCSRLTTPGVKALGYNVPDLQGLRLSGCTALTDAALEPIFASTPRLTHLEIEDLSDLTNSLLSEHLAKAPCAPWLEHLSISYCENLGDSGVLPVVKNCVNLRAMDLDNTRISDLVLAEAAYMVSNRSRSTAAKPKPRVGLHMVVYDCQNVTWAGIREVLFRNAQTKPSMSEVGKFAYSAEAISLKCFYKFQMTVDEHTKRVLRGDLAAANRLERRWADYMQANEEAGTTGAGHRRRRRRAREAQILHADEEDGGNGGRRRGRTVGSCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ57</accession>
    <name>A0A1B7YQ57_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162688.1">
        <property type="nucleotide sequence ID" value="XM_018297872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ57"/>
    <dbReference type="GeneID" id="28861979"/>
    <dbReference type="KEGG" id="chig:CH63R_02897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02897"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="42142" checksum="BEA442E746ED53A5" modified="2016-11-02" version="1">MPTLRRRGEAARAVEEPHIDETTTRAIEPIASHLESLETAPDGTVEALGVVNDAAEVAAANAEAKESEAAHISERDRDHQHSRRQRSHLPTVLQFPLVTVLSFSISSLCYSFLSEWSRGELAGISKSLDTWSDVATLAGWRIFELALGWFGNFDSYDLAALNLLAHGPPVYLIATFYNISPATAVSALGIEMLSTFVPFQLLRPLSGAHAGAKNVANREIITDIPIQIYTTILAAAIYSLTLFTAYKTYLPTTLVLYFEGLPSLAPAYTTNFLATLPVTIAFGIAARSFIFTPFVATGETDEDEKLAEFDPATATLGETLAWNIWGYTTREKVVILRTAVAMLVTGVNTYLQTFMTINGVESYGASLYAGAWVGAAFLTGVGLGFVGGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQD4</accession>
    <name>A0A1B7YQD4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162776.1">
        <property type="nucleotide sequence ID" value="XM_018297960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQD4"/>
    <dbReference type="GeneID" id="28862067"/>
    <dbReference type="KEGG" id="chig:CH63R_02985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02985"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7395" checksum="D88BB44260C2AF1C" modified="2016-11-02" version="1">MGEILLEANRWLESLHAIQSDRHGMNHPARPRPVDPSIATSLPIRRSTGDWATVLVPRLGFFRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQX2</accession>
    <name>A0A1B7YQX2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_03078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162869.1">
        <property type="nucleotide sequence ID" value="XM_018298053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQX2"/>
    <dbReference type="GeneID" id="28862160"/>
    <dbReference type="KEGG" id="chig:CH63R_03078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03078"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="142"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="359"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="541" mass="59087" checksum="BE30E3D35FFC4B8C" modified="2016-11-02" version="1">MPSSAAPRRPGPAADDEDPASSSSANSSGAESESDYLDSPASRKRRRTEPPAEPDLKDGDDDDDEELKAIVSTIKAPSRIKRAAAAVEEARQTVRPAPSQSTISAPTDPNTTFSAINVRPWLVQSLANMAIKRPTGIQKGCIPEILKGRDCIGGSRTGSGKTVAFAVPILQKWAEDPTAIFALVLTPTRELALQIFEQFKAISSPQSLKAILVTGGSDMRPQAIALAQRPHVVIATPGRLADHIRTSGEDTVCGLRRVKYVVLDEADRLLDATGPGSMIPDVEECLSVLPPSSQRQTLLFTATITPEVRALKDMPLKPGKQPVFVCEVDTQALAIPATLAQMHLQVPVTHREHYLHTFLLTDANAEKSVIIFCNRTSTADYLHHLLRLLDHRVTSLHSGLPQRQRIDNLGRFRAAAARILVATDVASRGLDIPEVGLVVNYDIPRNPDDYIHRVGRTARAGRKGEAVTFVGQRDVELVLAIEARVGRQMEAWQEEGVNLETRVLRDTLKVVSEKKREALLELEEGREVGGKRKRTKQKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRA8</accession>
    <name>A0A1B7YRA8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162945.1">
        <property type="nucleotide sequence ID" value="XM_018298129.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862236"/>
    <dbReference type="KEGG" id="chig:CH63R_03154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03154"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="335"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="4">
        <location>
            <begin position="869"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1558"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1675"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1734"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1778"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1700"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1784"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1847" mass="202761" checksum="AFF1AAB13F850765" modified="2016-11-02" version="1">MAAQLTPDLQDKLEELEKELQHPLSPPRRYQKRRTQLLSQFMAPGSFVPPAANESRRGLGIHSPDSSGHPSSDGHRAAALAALGGRDSDPNSPTSPTSHRPHSPFGGRGSAHGSGHGSGHGSAGYTSPPGYQSPGASFVSPEMNPAGLLRPGGPLAEHRPNMKHHDSLFLGSANEPTTRSGTMVSTDYAFNPDQQGHYVDHAQNPYDSRTGTMLDSTGYFSGFTGGQTFEQGQNYDQQGYDQGLQEDYGGGHRYSSGEAFSPTAAMAPPMLTANDLPPPEVLEYQMPLEPRDLPFAISDPHDSNTPMSKFDNMAAVLRHRGKTMSKLPAYWVLDNKGKEIASITWDKLASRAEKVAQVIRDKSSLYRGDRVALIYRDTEVIDFAIALLGCFIAGVVAVPINDLQDYQKLNLILTSTQAHLALTTDNNLKAFQRDITTQKLNWPKGVEWWKTNEFGSFHPKRKDDVPPLTVPDLAYIEFSRAPTGDLRGVVLSHRTVMHQMACLSAVVSTVPGNGPGDTFSRTLRDKNGRLIGAGATSETLLSYLDPRQGIGMILGVLLTVYGGHTTVWVENKAVEVPGLYAHLITKYKATLMIADYPGLKRAAYNYQSDPMTTRNFKKGMEPNFQTVKLCLIDTLTVDGEFHEVLADRWLRPLRNPRAREVVAPMLCLPEHGGMVISIRDWLGGEERMGCPLKLDMGSDIESDVEEKEEVKLAPSNGFGSLLGGGGTTTTEQRAKNELSEVLLDREALKTNEVVVIAIGDEARKRAASEHGTVRVGAFGYPIPDATLAVVDPETGLLASPHSVGEIWVDSPSLSGGFWALPKHTEQIFHARPYKFDPGEPTPTVVEPEFLRTGLLGTVIEGKIFVLGLYEDRIRQKVEWVEHGTEVAEHRYFFVQHLVVSIVKNVPKIYDCSAFDVFVNEEHLPIVVLESPAASTAPLTSGGPPRQLDTALLDSLAERCMDVLMQEHHLRLYCVMITAPNSLPRVVKNGRRDIGNMLCRREFDLGNLPCVHVKFGVEHAVLNLPIGVDPIGGIWSPISSDSRADILMSSDKQYSGIDRREVVIDDRTSTPLNNFSCITDLIQWRVARQPEELAYCTIDGRGREGKGVTWKKFDTKVAAVALYLKNKVKVRPGDHLILMYTHSEEFVYAVHACINLGAIVIPLAPLDQNRLNEDVPAFLHVVADFRVKAILVNHEVDHLVKLKLVSNHVKQAASILKIAVPNYYNTTKPPKQSNGLRDNGIMMQPAWIQSGYPVIIWTYWTPDQRRIAVQLGHDTILGMCKVQKETCQMTSSRPVLGCVRSSTGLGFIHSCLMGIYIGTPTYLLSPVEFAQNPMSLFVTLSRYKIKDTYATPQMLDHAMATMQGKGFTLHELKNMMISAESRPRVDVFQKVRLHFAATGLDRTAINTVYSHVLNPMVASRSYMCIEPIELWLDTKALRRGLIYPVDPEQDPKALLLQDSGMVPVSTQIAIVNPESRLLCHDGEYGEIWVDSEACVKGFYGSKDVFDAERFDGRTVDGDPSIQYVRTGDLGFLHNVSRPIGPGGAQVDMQVLFVLGNIGETFEINGLSHFPMDIEASVERCHRNIVTGGCAVFQAGGLVVVLAEITRKAYLGSVVPVIVNAILNEHQIIVDIVAFVNKGDFPRSRLGEKQRGKILAGWVTRKMRTLAQFAIRDMDPASLVGGDPGTADGSDPHRASIGSQRSAGGPAPGSSSLRNVEHAPQILEQEEFQNQVGHMASLPQHGHDGIAEMPGDEGPLYAQQGQANAPSGNDYVLPDFDHFGHDDRPPPVGAKPGPGQPTPQIKLPGVDGRENTDIWNSHKGGGQDDEDWTAQALMHMNLANDLDRKHGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS41</accession>
    <name>A0A1B7YS41_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163374.1">
        <property type="nucleotide sequence ID" value="XM_018295012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS41"/>
    <dbReference type="GeneID" id="28859119"/>
    <dbReference type="KEGG" id="chig:CH63R_00037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00037"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="98" mass="10803" checksum="2E4A5AD62F9B58F4" modified="2016-11-02" version="1">MASSDAKPAQDKTADLKADETTAQQQQAAAKKPALGEDDEFEDFPVDDWPQEETEAAAGGSGSTQHLWEESWDDDDTSDDFSAQLKEELKKVEASKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSF6</accession>
    <name>A0A1B7YSF6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cutinase</fullName>
            <ecNumber evidence="3 13">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_00160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 13"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163497.1">
        <property type="nucleotide sequence ID" value="XM_018295135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSF6"/>
    <dbReference type="GeneID" id="28859242"/>
    <dbReference type="KEGG" id="chig:CH63R_00160"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00160"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013040207" description="Cutinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="239" mass="25079" checksum="6C5CEDAAA6CACA0E" modified="2016-11-02" version="1">MKFLNVLALASVAAAFPTLSDTSINDVDVRELEARELEARQRSGRVGSTAKEFTEGGCKDVIMFFARGSTEVGNMGTVCGPPTANGVKANFQSVAVEGVDYAAGLATNTLPGGADPRGIAEMKRLIAQANADCPDSMLVVGGYSQGAALTHRAVEDLPQAQKDQIVAAFTFGDTQNLQDGGRIPNFPPEDTKIICAAGDAVCRGTLTILPAHLSYGRNADEMADFISQKLTAAGAQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSF8</accession>
    <name>A0A1B7YSF8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163409.1">
        <property type="nucleotide sequence ID" value="XM_018295047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSF8"/>
    <dbReference type="GeneID" id="28859154"/>
    <dbReference type="KEGG" id="chig:CH63R_00072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00072"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="396" mass="43705" checksum="71B322BFABF2DDDF" modified="2016-11-02" version="1">MSVQEGAFPPPDGKVASLGNPEDVLHSINLVSQILSITLITLFMVLRVYTKSIVAPPFHTDDCESNPVFAMSVPLMRTILMRRLRDVVDSISLITLVQVGRFGGGFHVYEISKESYKGFKKLALLWIVIRVFGLHKKTIIGTYSIIFLLTGYTIPVMFLKGFICRPLAGFWDSAVKTTCYNQRAILLADTVVSAITDMAVLCIPIPVAVTLRMSWKKRLKVIAMLSSGGIATAASIIRLVLVIKLQNSHDETIDLIRFNLLGTAEVSIGLICACLPAVNILFLRGFERATDSSRGTLGSIIEFKFLRGSRLRTQQLTTTEVAPDTAREDVPVVRPGPTQEAREDYIFSVERISRPPPATLQGDPETGESRDDWYSNVMASPFSEPGSPDWARKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSN3</accession>
    <name>A0A1B7YSN3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163425.1">
        <property type="nucleotide sequence ID" value="XM_018295063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSN3"/>
    <dbReference type="GeneID" id="28859170"/>
    <dbReference type="KEGG" id="chig:CH63R_00088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00088"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="379" mass="41944" checksum="9785761AC2928ADD" modified="2016-11-02" version="1">MAVEFEPFEVPGARSYFGHALPYGLQVKQKGDNGNAPPVAESAAALRALGESGRLQELLERHGAVLVRGAGQPSAETFSRLVGAAERGRGSLPHVQIGLAGKRTPLAENVWTANEGSPSTRFYQHNEVRSVAPKRETPHLWLTRSIYTRFPSNIHFYCVKKAPKGGATPIANSANVFEKVQAEIPELVEEIRKRGLGMKMIFRAPGDEAKVNQFNWAGEHSFGQELLPGDDEATTREKVERQVRRLTSDFKWNADGSLELTQHIPGLRRLPASGRPVWFNGLVGRHGITRDIGALDPPHIGRDGMTYLPCVYGDETPIPRELLDKLIEVIDKEEISLVLEEGDLLLVDNFQVSHGREPWEGDRQILVSMWDASTPIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSZ2</accession>
    <name>A0A1B7YSZ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_00327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163664.1">
        <property type="nucleotide sequence ID" value="XM_018295302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSZ2"/>
    <dbReference type="GeneID" id="28859409"/>
    <dbReference type="KEGG" id="chig:CH63R_00327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00327"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="49"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="435" mass="46067" checksum="6DBD21F4C06C1245" modified="2016-11-02" version="1">MRDPEEQEVQDHAASAAAVAPGTPEAVELRAMGSPRSGSSRREPESSPLAWLCVVGSFMFLYPSYGFMQSVGTVQSYLQLNQLSAYPSRDLGWISGIFTSLGLLLGIQAGPLMDAYGTKFLAPASVVLYVPVFFIMGECTEYWHFILCLGVLGGIGGALASTVAMAVIGKLFNRRKGLAMGIALSGSSFGGVTISMMLRSILPTLGWQWSMRVMGFLVLGIMTIGVLCFLPYPRLCVAVAGAPVGKTGAMLNFSAFRSPPFGFMTMGLFLLEFVLFGITGLLPTFAIASGFGSDVGYSLIAILNGTSCLGRIMTGIIGDRLGHLNILLTMIGITIVFTGVVFVPFGTKHIGALYAFAALWGYGSGSFLSSTPGTMNFIVSFSLLVTVPIGGQMLESMGGTALSGFYLAIVFLGGVCFFAARALLLDGWLTFRARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUE2</accession>
    <name>A0A1B7YUE2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calreticulin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164071.1">
        <property type="nucleotide sequence ID" value="XM_018295709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUE2"/>
    <dbReference type="GeneID" id="28859816"/>
    <dbReference type="KEGG" id="chig:CH63R_00734"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00734"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447792" evidence="9">
        <location>
            <begin position="21"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="571" mass="63124" checksum="FF6F7F58775C0D90" modified="2016-11-02" version="1">MKFNAAAFSAAALLASSAYADDAQKVLSEDKTSTAAESATSVAPKLATFTPTTLKAPFLEQFTDDWESRWRPSHAKKDSKDDEEWAYVGEWAVEEPTVYKGVEGDKGLVVKNPAAHHAISAKFPKKIDNKGKTLVVQYEVKLQNGLECGGAYLKLLRENKALHQEEFSNATPYVIMFGPDKCGHTNKVHFIFNHKNPKTGEYEEKHLTAPPTARIVKTTELYTLIVHPNNTFIIQQNGEQVKTGSLLEDFSPSVNPEKEIDDPKDSKPEDWVDEARIADPEAKKPEDWDEEAPFEIVDEEATKPEDWLEDEPLTIPDPEAQKPEDWDDEEDGDWVAPTVPNPKCTEASGCGPWTKPLKKNPDYKGKWTAPYIDNPAYKGVWAPRKIKNPDYYEDKTPANFEPMGAIGFEIWTMQNDILFDNIYIGHSVEDAAKLAEETFKEKHPIEQLAELADKPKEAEKPKSPSDLKFLDDPVHFIKEKLDLFITIAQKDPIQAVKFVPEVAGGIGALLVTIIAIIVGLASSGGAPPAAKKAAADAKDKAKDVKDKASKAIASGADVAKDATKRNTRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUU7</accession>
    <name>A0A1B7YUU7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164338.1">
        <property type="nucleotide sequence ID" value="XM_018295976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUU7"/>
    <dbReference type="GeneID" id="28860083"/>
    <dbReference type="KEGG" id="chig:CH63R_01001"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01001"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="197" mass="21509" checksum="BCEC00BE19CF54CB" modified="2016-11-02" version="1">MGAPRADYAKNQDKPPSRHVHVSTNSTRLLDAPGLPEGLLPFGLSPPPPNGFLLTVRCPEPSGQEVHLPSKKKHCQTGPGQAPPLHLGCWAPYMGLDLSVKLSEINNRRNRTPPPPPPPPRENNCGYLTGLSTRRFLVPQTETNIETILQPDEQTPSISRPVHWYRAHGFALDHMSLLLMRAVGSTPLGYLSVSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUZ4</accession>
    <name>A0A1B7YUZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164387.1">
        <property type="nucleotide sequence ID" value="XM_018296025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUZ4"/>
    <dbReference type="GeneID" id="28860132"/>
    <dbReference type="KEGG" id="chig:CH63R_01050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01050"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="112" mass="12752" checksum="843D0235AE625528" modified="2016-11-02" version="1">MKDERVSDSRLSQVRPGERVANFPNRKVRMDHVCWNTIWLGSINKSNQIKREDKKAVVAVKANMPMVLQIHRFPTSRQPLHSHAARRICSKRVSEFAGTVRCTSDSEGLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV35</accession>
    <name>A0A1B7YV35_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_01087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164424.1">
        <property type="nucleotide sequence ID" value="XM_018296062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV35"/>
    <dbReference type="GeneID" id="28860169"/>
    <dbReference type="KEGG" id="chig:CH63R_01087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01087"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="14">
        <location>
            <begin position="143"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="438" mass="47367" checksum="E6899308CF700250" modified="2016-11-02" version="1">MAITKIHARYVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEACELRDGDKTKWGGKGVTKAVENVNSVIAPALIKENLDVKDQTKIDKFLIDLDGTSNKTKLGANAILGVSLAVAKAGAAEKGVPLYAHVSDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSAAPSFTEALRQGAEVYQALKGLAKKRYGQSAGNVGDEGGVAPDIQTAEEALELITDAIEQAGYTGKMNIAMDVASSEFYKEDVKKYDLDFKNPDSDPAKWITYEQLAQQYADLSKKYPIVSIEDPFAEDDWEAWSYFYKTQDIQIVADDLTVTNPLRIKKAIELKAANALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTISDIVVGIRAGQIKTGAPARSERLAKLNQILRIEEELGENAIYAGANFRKSVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVY9</accession>
    <name>A0A1B7YVY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164555.1">
        <property type="nucleotide sequence ID" value="XM_018296193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVY9"/>
    <dbReference type="GeneID" id="28860300"/>
    <dbReference type="KEGG" id="chig:CH63R_01218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01218"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="258" mass="28523" checksum="78A75C42E7079172" modified="2016-11-02" version="1">MRHTNIPCEARYGEQDPGASVLSASKAHFAAQAMTRTSLRLNPASMTVYCLCGGAVQTWFYGFPGAASAWLNLTQRSLEELFPVLCASIPGAVNLTGGAFSPLSTQGFLCILLPSLDIKLQNATVTYFCTHSPFAFADFETLNSTSASREAQSRFERCLSTSFTNRNSTSEFNMSDIVDLFDKVKIPSWIDETDENWKDVSSKPGKTHWSSLAGISLEHSLIENKTVSVESSYVQIQHSFVDEDAQKRKPMIMKHKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW59</accession>
    <name>A0A1B7YW59_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructosyl amino acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164794.1">
        <property type="nucleotide sequence ID" value="XM_018296432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW59"/>
    <dbReference type="GeneID" id="28860539"/>
    <dbReference type="KEGG" id="chig:CH63R_01457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01457"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="105" mass="11414" checksum="4AA9CB91FA58591D" modified="2016-11-02" version="1">MNETAKPSVFIIDGNVVGTSTAYHLAQWVVTVLKGLQSTLEWRSPPPPPPPASLFASMYRESGWLMAGHSLARSQLDSTFETVTGASRKAVWVPNGWGDEKQGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVN2</accession>
    <name>H1UVN2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04497</name>
        <name evidence="3" type="ORF">CH63R_01911</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000301">
        <property type="protein sequence ID" value="CCF32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161702.1">
        <property type="nucleotide sequence ID" value="XM_018296886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVN2"/>
    <dbReference type="STRING" id="759273.H1UVN2"/>
    <dbReference type="GeneID" id="28860993"/>
    <dbReference type="KEGG" id="chig:CH63R_01911"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01911"/>
    <dbReference type="eggNOG" id="ENOG502SJF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069864_0_1_1"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="243" mass="27566" checksum="5F0D058813C0154C" modified="2012-03-21" version="1">MEPEIVKLATKIYITTPSTFTKKEYAPAERPTDIQGKPIVWKWASERLQNEGMALALIKDHTTIPVPRVIQCGPDSDGAMCLEVQYIDGIPCDVAGEKCRMPLDQAHTTGHCPECQKIASENTNIFIETEVIPQLRLLRSNKTGLNGVVIPPPRIEQFDCRDVWPPKKSSKGEEYVFCHGDLTRSNVLLDPNTLMVKSIIDWESAGFSPEELELSLWRLNYDEYMRTFEDTDKIKQEIELITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW25</accession>
    <name>H1UW25_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00765</name>
        <name evidence="8" type="ORF">CH63R_03347</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000346">
        <property type="protein sequence ID" value="CCF32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163138.1">
        <property type="nucleotide sequence ID" value="XM_018298322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW25"/>
    <dbReference type="STRING" id="759273.H1UW25"/>
    <dbReference type="GeneID" id="28862429"/>
    <dbReference type="KEGG" id="chig:CH63R_03347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03347"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555981" evidence="5">
        <location>
            <begin position="22"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="519" mass="55135" checksum="C4CBBBB12475B4E9" modified="2012-03-21" version="1">MVLGRYLGAVASLGLSVQVLAHLNTTSTGFKGCDALLNAGLGDVLVFPTDLAYTESTSTYYSSENRRLRPYCIVQPRSSVQVSDAVKALSGLSGAGNWDVAVRSGGHSDYDNNAVNRGVTIDLTFFNSTELVKSNCLNGSATWVGKSTLTKNVAQIRPGARWGDVMTTLEPYNLGVTGGRSGHVGVGGLLVSGGASYHTQLYGLSCDNVVGYEVVLADGSIVEANLEENQDLFKALKGGGSNLGIVTRFDLRTFTVPPEGAYGGLVFASWRDLDVMIGQFVSYASSIGTGSPDHEFLVYRSDYGNLAVMAMSVSTDGNETSSTFVAFDTIALTIDRRVKQPLSKIAATIADTGGSHYIPFTLSLQATKEVMNKAADIFVALTREFDGSGIPVSVNFVFQPLPKSPAAVTPGGNILGFDMNLPADSILFEARGTLAAVDAGYGGIVQSKMGQAIEELRAYSASLEGHSTYIYMNYANPEQDVLGSYGAENVEFLRKTAAKYDPTGFFQDRVPGGWKVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXF4</accession>
    <name>H1UXF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04995</name>
        <name evidence="4" type="ORF">CH63R_04101</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000493">
        <property type="protein sequence ID" value="CCF32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160322.1">
        <property type="nucleotide sequence ID" value="XM_018299076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXF4"/>
    <dbReference type="STRING" id="759273.H1UXF4"/>
    <dbReference type="GeneID" id="28863183"/>
    <dbReference type="KEGG" id="chig:CH63R_04101"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04101"/>
    <dbReference type="eggNOG" id="ENOG502SURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050872_0_0_1"/>
    <dbReference type="OrthoDB" id="5427732at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="441" mass="44080" checksum="261B1E54E5272AFE" modified="2012-03-21" version="1">MASDTKFDQHLEEGLLPVAANEKGIPATTQRPSRTPNKMTAARRVLLTVLVCGLMTLGLASAIGHRARPCTRHHQEQVLVAEGEAQDPAKVDLIHRLLHAYFPDRYQDGVYPSDKDAIAAFEADDAELASALGQLAKRQDNGTTTPSATPTPPATDTPSATETPSSPASSAPPASDTPTPTPTPTPTPSPSPSPSPSPSTPATSSTPEPVTSTVQSNTQQQTTPQSSQPAPTTPTTPATSAAPTTSGTFQTEPTASPSSTVGSSSVSTESPPTTSGSPSSSSSAVPSSAPSSAPTTVSSGSSSASAQGTSTSLSVETTTAVVTTSSPTISSSPVSTVLSTVSLSVSANTRQTPTTTGPSPRTTSFSEVRSTFTSTASNGEVVLVTATSFVAVNPEPAATESSDSSSGGGGGLQNVASPVGGVSIALPLTLAAFVAGAMLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXS9</accession>
    <name>H1UXS9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TfdA family Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_00864</name>
        <name evidence="9" type="ORF">CH63R_13796</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000535">
        <property type="protein sequence ID" value="CCF32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151088.1">
        <property type="nucleotide sequence ID" value="XM_018308770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXS9"/>
    <dbReference type="STRING" id="759273.H1UXS9"/>
    <dbReference type="GeneID" id="28872877"/>
    <dbReference type="KEGG" id="chig:CH63R_13796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13796"/>
    <dbReference type="eggNOG" id="ENOG502QS4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="36"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="367" mass="41093" checksum="DA61003735F1C8F6" modified="2012-03-21" version="1">MAPTAIDTEVPIHISAKSSHPQPLKVSAALDQYESFDVTPNIGREFPKANLVDWLNAPNADELIRDLAITISQRGVVFFRAQDNLTNELQKKLILRLGELTGRPSDSGLHIHPVLNSERELGGSDPEISTISSIQNKKYYRKPLEGEHISPKKQTTAQWHSDISFEPVPADYSSLRLVELPKTGGDTLWASGYEIYDRLSTPYQKFLESLTVTFEQPGFAAAAERGGFTLYDKPRGNPKNIGSILKAVHPVVRTNPVTGWKSVFPVGGHVKHINDVTPEESKHLLDWFLDLLQKNHEVQVRFRWQNANDIAIWDNRSTFHTATFDYDGQGERFGNRAVGIGETPYQDPNSTGRREALGLPQVTSEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXT4</accession>
    <name>H1UXT4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_05104</name>
        <name evidence="13" type="ORF">CH63R_10191</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CACQ02000536">
        <property type="protein sequence ID" value="CCF32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154589.1">
        <property type="nucleotide sequence ID" value="XM_018305165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXT4"/>
    <dbReference type="STRING" id="759273.H1UXT4"/>
    <dbReference type="GeneID" id="28869272"/>
    <dbReference type="KEGG" id="chig:CH63R_10191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10191"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_84_4_1"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="248"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="636" mass="69907" checksum="099869516BCF4782" modified="2012-03-21" version="1">MPASRTHQNGAAQFNQKLKNLFRINLNSGADRDREKSSAAHLQSSTDASPARPEARSKFGSSFFKGTVGRLRTNTTASEGNPLDEALSPTAHANPYFVHQGQPGLRHHNNESVPPSPPDTPNFKIQGPDGGPEQQTTSAGREELARKLRRVASAPNAQGLFSKGKGSAERPATAELSKDPLVLDKDSGTLEMVDPSKVNGSAGHGLGVPDKDVLGNLPPPNRNSLAFRRTYSSNSIKVRDVEVGPQSFDKIKLIGKGDVGKVYLVREKKSSRLYAMKVLSKKEMIKRNKIKRALAEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEEDARFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSDLGGKPTMIVGKTGTSTTSLHIDTRSCIANFRTNSFVGTEEYIAPEVIKGSGHTSAVDWWTLGILIYEMLYGTTPFKGKNRNATFANILREDIPFPDHAGAPQLSNLCKSLIRKLLIKDENRRLGAKAGASDIKAHPFFKTTQWALIRHMKPPIVPVTGRGIDTVNFRNVKESESIDLSGSHPMQASLKGVPLDSGLATPGGEVAVDPFEEFNSVTLHHDGDDDHHHSQQNGQYQHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYA3</accession>
    <name>H1UYA3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_00894</name>
        <name evidence="2" type="ORF">CH63R_06032</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000591">
        <property type="protein sequence ID" value="CCF32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158857.1">
        <property type="nucleotide sequence ID" value="XM_018301007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYA3"/>
    <dbReference type="STRING" id="759273.H1UYA3"/>
    <dbReference type="GeneID" id="28865114"/>
    <dbReference type="KEGG" id="chig:CH63R_06032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06032"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="293" mass="33052" checksum="6D0442141CF99727" modified="2012-03-21" version="1">MTAPSLLDRLNRDGFVVVPSILAEDQLTKLRHATQQATALARAGKWPNVRTLPKQFPPWPTATPEAPPQGIWGVQSMMHPDMPNSDIFVQTYFSDAVIEPTKQLLQCSDNDLVMELFNLLVRPDQDFELRWHRDDIPATATPEQELDRLNKPAYSAQWNLALYDDNSLIVVPGSHTRARTDVERNADPYEKEIPNKLLVELKAGDIVFYNNNILHRGAYVANKERMTLHGSAGHVKGSSLRARNVLQHGLKDWVDRVDLGALGERERARAKNMRRMLVEMGQEAGEVGYSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYY3</accession>
    <name>H1UYY3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">CH063_00927</name>
        <name evidence="11" type="ORF">CH63R_01184</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02000668">
        <property type="protein sequence ID" value="CCF33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164521.1">
        <property type="nucleotide sequence ID" value="XM_018296159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYY3"/>
    <dbReference type="STRING" id="759273.H1UYY3"/>
    <dbReference type="GeneID" id="28860266"/>
    <dbReference type="KEGG" id="chig:CH63R_01184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01184"/>
    <dbReference type="eggNOG" id="KOG3154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_0_2_1"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000913">
        <property type="protein sequence ID" value="CCF33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164681.1">
        <property type="nucleotide sequence ID" value="XM_018296319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0U0"/>
    <dbReference type="STRING" id="759273.H1V0U0"/>
    <dbReference type="GeneID" id="28860426"/>
    <dbReference type="KEGG" id="chig:CH63R_01344"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01344"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007914_2_0_1"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="777" mass="88665" checksum="99B051231EFA77E6" modified="2012-03-21" version="1">MHPLSVLSVGIFVAGYITARWDLVTRLYELAIFAWDYGVVTRAAKGFALLTFVYLLIFIPVERLATKEANLPEADMPENDGLMRIFWPTDIQRSDLPGVVVGWRNSSLDVFVVAILDDVDAGHVEFALKIGTLFRNSPHPVYSIYERCGHGAMHVLGLANPSDAVVLDPSLFVATTPAAAKVPRITCAKALSIQIILYDRPRPGRMQYISLNPISLALGNKEAPGLPPTEHMAEEEKQELKLKEQKRKLVDKLRLHTIIKRSPSPKEKALPKIVNQINWSWELEQLLQKNISRIGTRPKRTLSVSERVVENVTTVRNFVWDLLILYVLPLIQWGFVYMLMGHRAVAELLLQILEFRLKDNSLALKDISATAQQVEIRLQQFCYWPMQYTTLRQRKNDWESVTTSHPDYIRFYNSLWLVANDVIIGIALGSYIIDNAEWAASAISGLLKVYTVEALQRSITWLMGCPGGLKLNEDLASFLGDLFLWVIDYWSNCIATLEPVLPHVIWFIGFSSFAGASMPIAMFSDLLSGLTVHIYSFYLASARIYHWQLTILISLFHLFRGKKHNVLRNRIDSCDYDLDQLLVGTILFTLLFFLLTTVVVFYLNFAVARMVIISLKAVFDTLLSCLNHFPLFALMLRVKDPRRLPGGIRFELRDTHDYRLSNTSNEPPTSVIYLKSIPLTFRAMFHQYFQMGNRIRKHYLSPQVLLCLLTGQFVPPLNRKNLYSLQYSMLPARRANFRQMWDAITTAQPSRKPAPFVMNGRRYPTGLGGGGRTRYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V664</accession>
    <name>H1V664_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07441</name>
        <name evidence="3" type="ORF">CH63R_10948</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001660">
        <property type="protein sequence ID" value="CCF35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155346.1">
        <property type="nucleotide sequence ID" value="XM_018305922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V664"/>
    <dbReference type="STRING" id="759273.H1V664"/>
    <dbReference type="GeneID" id="28870029"/>
    <dbReference type="KEGG" id="chig:CH63R_10948"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10948"/>
    <dbReference type="eggNOG" id="ENOG502SJRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010779_0_0_1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556238" evidence="1">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="332" mass="36599" checksum="F839B9AAF2AC0466" modified="2012-03-21" version="1">MRVLSILTAVASAAALVVGNPVARQTPSFAGYLISTFSDANPKVQFHLSNGNSASSFKFLNKGQPVLTSNVGTKAVRDVFLTTNPSRSEWYIIATDLDINAAGFNWDKATRTGSRGIVVWKSTNLVDWSAPSLRVVEADTAGMVWAPSAVWDDAKGHWYVFWASRHYRSTDTAHTGTATLDRIRYTATKDFVTFSPARDYVALADTPLIDQEFQYLGTPGAYARFLKNETTNQVYQEVTSNGIFGTWRRIPGYVRSESPREGPASFADNTTPGLYHLLLDDYTQYVPFQTNNIQSPSWQGSSTSGFPRGLKHGSVTPLTQAEWNALNSRFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7E7</accession>
    <name>H1V7E7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07783</name>
        <name evidence="3" type="ORF">CH63R_01636</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Will I."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF37052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein localization to Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein localization to phagophore assembly site"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein targeting to vacuole"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF37052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13712.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="181" mass="19956" checksum="CB631409DFF65E60" modified="2012-03-21" version="1">MGASMSWLSGLLWSKKEIRILILGLDNAGKTTLLYRLKIGEVVTTIPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIERLQTAAEELGAMLNEEELKDASLLVFANKQDQPGAKGAGEISEALRLGELRDRNWSIMACSAVDGSGVTEGMDWLVQTVNQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VA21</accession>
    <name>H1VA21_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08495</name>
        <name evidence="11" type="ORF">CH63R_11053</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002291">
        <property type="protein sequence ID" value="CCF37074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152868.1">
        <property type="nucleotide sequence ID" value="XM_018306027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA21"/>
    <dbReference type="STRING" id="759273.H1VA21"/>
    <dbReference type="GeneID" id="28870134"/>
    <dbReference type="KEGG" id="chig:CH63R_11053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11053"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="8">
        <location>
            <begin position="141"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF37074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="482" mass="53491" checksum="A69836B760B6FD1C" modified="2012-03-21" version="1">MASTTSSTPAAQNPVLRRTVTSTTTETDASVPSTAVASPMDSPRPSASSTSLSSMASDDVAPKSANYGKLFDTYGNEFTPPDFTIKDIHNAIPKHCFERSALKGFGYIARDILCLATTFAIWYNFVTPEYVPSKAARAGLWAVYTVFQGLFGTGLWVIAHECGHQAFSPSKTLNHTVGWVLHSALLVPYFSWQISHSKHHKATGHMERDMVFVPRTREQHASRAGRLVHEVAELTEETPIYTFLMLIAQQLVGWPNYLMTNVTGHNFHERQREGRGKGKHNGYGGGVNHFDPSSPIFEAKDAKLIVMSDIGLAITISILTLLGNKFGWSNLLVWYFIPYLWVNHWLVAITFLQHTDPTLPHYTADQWNFVRGAAATIDREMGFVGRHLLHGIVETHVLHHYISTIPFYNADEASEAIKPVMGKHYRADVQDGPVGFIKALYKSARMCQWVEPSAEAHGDGKGVLFFRNHNGLGTPPIKGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAH4</accession>
    <name>H1VAH4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OST3/OST6 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_01656</name>
        <name evidence="12" type="ORF">CH63R_09447</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002368">
        <property type="protein sequence ID" value="CCF37227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156444.1">
        <property type="nucleotide sequence ID" value="XM_018304421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAH4"/>
    <dbReference type="STRING" id="759273.H1VAH4"/>
    <dbReference type="GeneID" id="28868528"/>
    <dbReference type="KEGG" id="chig:CH63R_09447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09447"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_1_1"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497627" evidence="10">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF37227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="36336" checksum="85F2803F7D5E9623" modified="2012-03-21" version="1">MRFFQSLLVATSFAAGAFAAKKTTEERFNEFHAKALTLSPIKLADTSYKSLTSAPRDYSVAVLLTALENRFGCQLCREFQPEWDLLGKTWTKGDKKGESRLLFGTLDFSDGREIFMSLGLQTAPVLLLFPPTVGPHAVAVADPLQYDFTSGAQSAEQVHAWLSRHLTDRPHPPVSRPINWMRLISITTIVLGAGTVLVTASPYILPVIQNRNLWAAISLIAILLFTSGHMFNHIRKVPYVAGDGRGGISYFAGGFQNQFGLETQIVAAIYGVLAFCAISLTVKVPRIGDNKRQQVAVIAWGGVLFLMYSFLLSVFRIKNGGYPFSLPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBB8</accession>
    <name>H1VBB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_08831</name>
        <name evidence="5" type="ORF">CH63R_09150</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002498">
        <property type="protein sequence ID" value="CCF37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156147.1">
        <property type="nucleotide sequence ID" value="XM_018304124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBB8"/>
    <dbReference type="STRING" id="759273.H1VBB8"/>
    <dbReference type="GeneID" id="28868231"/>
    <dbReference type="KEGG" id="chig:CH63R_09150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09150"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054410_0_0_1"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497629" evidence="2">
        <location>
            <begin position="22"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="48"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="418" mass="45713" checksum="59E4302BC8324C01" modified="2012-03-21" version="1">MIFNTFTHAALLASLFSSANGSPFPLTTRNGGIAVLDVFVPSSRNDDKFYNVNVTFNGQAVPVMIDTGSGDLFVASNECPTDDDQDGCFGLTSSYVIKPNDTILSNETFFTIVGEGAVYGNQSLLRTDFGGLSIPDLAIGLVYESALKEFQNDSFSGIFGLNMRAVSRQLHFNNRLPPMDVLLATEKLREPKFSLSFPRLGDPDSAEVGKLTLGGLGEEAAGHDVTYGPVYSTPNYNYDDFPLDRQGWTVHLEGVRVNGVEIKMRAGVLLPDGKYLSMIDSGGSLMYFRPEELDAIAAQFKGPILYPGNRDIYFDCSIPQLMELKYFGEWYAVDPLDLVIPSDHGLVNGTEYCHAALGQWTRTFGDSIIGLPFLRSVFSVFDYISNDLVPQPRVGFASLVDGADAVARYSNVLPSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDB0</accession>
    <name>H1VDB0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01863</name>
        <name evidence="7" type="ORF">CH63R_11588</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">IMI 349063</strain>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003051">
        <property type="protein sequence ID" value="CCF38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163573.1">
        <property type="nucleotide sequence ID" value="XM_018295211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEE6"/>
    <dbReference type="STRING" id="759273.H1VEE6"/>
    <dbReference type="GeneID" id="28859318"/>
    <dbReference type="KEGG" id="chig:CH63R_00236"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00236"/>
    <dbReference type="eggNOG" id="ENOG502SHDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007003_7_1_1"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR15056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="41343" checksum="CEE9AEE48EBFD3D0" modified="2012-03-21" version="1">MLSLQVSRVRLPPRKEYVAALQARVKTLEAELALARESGWGGDSGSVAGTEPPAFNNKDDVASPESTASHGTSGTSSAAIEEVTDILGRFAIGDGGELCYFGSRSNFNLMRSSTVRSTSNMGMQRRGYEAAAAQVGLVEVSRDLQSHLLHLFWSWQNSWQYIVCEGPFLQDLGSHPDSPFGRFCSPALLYAILALASRYTDDIRVRTDPEDPRTAGDAFAAQARVMLLYECETPTPTTVQALALTCLREMALNKEALGWMYCGMCVRMAINLGMHLDCSPCVSEGTLSAEEAEVRNVTWWGCYVLDKLFNIGLGRPSMIQARDVTAEPPNTCCMEELRPWQATDVLPNPILATASHNVTNAIYTCKLFTLMGDILDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEH0</accession>
    <name>H1VEH0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_09668</name>
        <name evidence="5" type="ORF">CH63R_06138</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003067">
        <property type="protein sequence ID" value="CCF38623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158963.1">
        <property type="nucleotide sequence ID" value="XM_018301113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEH0"/>
    <dbReference type="STRING" id="759273.H1VEH0"/>
    <dbReference type="GeneID" id="28865220"/>
    <dbReference type="KEGG" id="chig:CH63R_06138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06138"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_2_1_1"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="302" mass="32097" checksum="23BE37F0E031B013" modified="2012-03-21" version="1">MASDSSTPFSRLVRFVPRSEPSKILIGEPESDSVDVGIAVRNGEEVKVAVWSGSSVLKPGSKTDQRAVIDRVLSPVSAEEVGTIRCIGLNYVQHAKEVGVALPDVPTVFLKPSTALGDPWPAPTVLPLLTQADDCGDYESELAVVLGKTAKNVSEANAMDYVLGYTACNDVSSRTYQLNQSQWCFAKGFDGSCPLGPTLVSKDLIPDPSKLKMRGLWNGDVLQESGIDDLIFSVPKIISFLSQSTTLPAGTVIITGTPAGVGLGRKPKVTLKDGDEFRVEILPHIGTLVNAFQNEGVTAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFE6</accession>
    <name>H1VFE6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALG13</name>
        <name evidence="9" type="ORF">CH063_00301</name>
        <name evidence="10" type="ORF">CH63R_09350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="CACQ02003235">
        <property type="protein sequence ID" value="CCF38949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156347.1">
        <property type="nucleotide sequence ID" value="XM_018304324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFE6"/>
    <dbReference type="STRING" id="759273.H1VFE6"/>
    <dbReference type="GeneID" id="28868431"/>
    <dbReference type="KEGG" id="chig:CH63R_09350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09350"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_1_1"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF38949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="244" mass="26827" checksum="8E06ED1F7826A56F" modified="2012-03-21" version="1">MAMNVDSKKTLGVERHCLVTVGATARFTQLLTEVLGSTFLDFIAANRYTHLTLQCGDDYDHFSRHVLPPLLERYPTLQITAFAFVDDLAVEMAKCRAHPGLREAGVVICHAGTGTILDGMRVGVPLVVVPNPTLKDNHQVELAEEIQRQGYGIWGRLGDISWALEQLALLLDKTERQFSPHPVANEVAPLNVDLWQVSGAMMGRYSGEPTTAFKAPAKVEGSEGSITGARREVQREEVAQMTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGE4</accession>
    <name>H1VGE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fpd1 benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_10164</name>
        <name evidence="7" type="ORF">CH63R_03845</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003415">
        <property type="protein sequence ID" value="CCF39297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160066.1">
        <property type="nucleotide sequence ID" value="XM_018298820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGE4"/>
    <dbReference type="GeneID" id="28862927"/>
    <dbReference type="KEGG" id="chig:CH63R_03845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03845"/>
    <dbReference type="eggNOG" id="ENOG502S43V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054062_0_0_1"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF39297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="34337" checksum="83D8F751BB1EF5A8" modified="2012-03-21" version="1">MSGLTAQHKQSPLQDLFHIITMLPTTIRSPPSLGDFIPIEEHQAQTPETFFGGKPVLHFHLDGAKAWIPASQKGSLAVFPADVATAASAPEGTTLRELSEELVEQLVSVFVTSENFTVFSAAQGAGVEIPYPSISIHAVKQVGTTAEGTPLQAIWMQLQLGDGGDGDDDFETIDLTLIPALTAGSPQADIQKFYDAISACSDLHPDPVDEEDDDEDGRIVFEGEREHEPVEGYTGVLYGAHDGGLPPAFPGSGGWITAENVHEHFDADGNWIGQNGAEEDGEVDAEGGELGEGAGRVRGHDEVNDGVNGHDDPDNKRPRVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIJ6</accession>
    <name>H1VIJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulphydryl oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_10713</name>
        <name evidence="7" type="ORF">CH63R_11386</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003842">
        <property type="protein sequence ID" value="CCF40049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153201.1">
        <property type="nucleotide sequence ID" value="XM_018306360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIJ6"/>
    <dbReference type="STRING" id="759273.H1VIJ6"/>
    <dbReference type="GeneID" id="28870467"/>
    <dbReference type="KEGG" id="chig:CH63R_11386"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11386"/>
    <dbReference type="eggNOG" id="ENOG502S1DJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_0_1"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556603" evidence="4">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF40049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="398" mass="43159" checksum="5103450129FDF482" modified="2012-03-21" version="1">MKFSLSSLVLSAASSLVLATPIDNTFVYDAVIIGGGPAGLSVASALGRVRRNTLLIDSGEYRNAPTRHMHDVIGFDGVTPAWYRYAAREQISHYKTVTLTNGTVTKIAGSDAENFLVTTNCADNSLKTVRTRKIVLATGLKDNLPETPGIWENWGKGIYWCPWCDGHEHADQSLGLLAASFSDLPSLVREILTLNTDLVAFANGTDTEAARAETEAKNPKFQEFLDLHKVPVENRTITAITRLRNADDDPKADPSLPTAPEHDLFSVEFAEGDPIQRAAFLLSFPDEQRSTIGAETGVQLWGGRLAAESSKGHATNVPGIYAVGDANSDNSTNVPHALFSGKRAAVFLHVRLAKEDQAKETGVNVTALRRELELDERSVWEAANGQPGEILYAGEFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLP5</accession>
    <name>H1VLP5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf636 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_11511</name>
        <name evidence="7" type="ORF">CH63R_08003</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Sisk P."/>
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                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </evidence>
    <sequence length="330" mass="36029" checksum="B06EDDAC5D2FCA53" modified="2012-03-21" version="1">MSPTMHLAPHTAAYAPTSDAMDRHEYGVTKNRKAASTGGGRAWSEDEEVYLLQTRLQKMPYKHIAAHLKKTELACRLHYHQLSHGSNRRKQRTTSVSSGSSVNHSPVMQPTMPTPIRESTPRSVSPPGRSTSYAPVSPAPMQLPSIMGNGASPRLPAILPKPVCMTLPPRTASPNRGYPTPLPEPHSAPLPPAAFQSMSGSLPMTPPLRLECALPPPQPPVNHHHVDMNRLQSVYTAHRDSFWAAVANDYGPGASPVLLEQAWKSGACCSQHQANTPITPTSSPDNTDRDGYDKPQDKTRISAILGIDANPRSPRERELVRRMEEQRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNN8</accession>
    <name>H1VNN8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_12004</name>
        <name evidence="3" type="ORF">CH63R_10031</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004976">
        <property type="protein sequence ID" value="CCF41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154429.1">
        <property type="nucleotide sequence ID" value="XM_018305005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNN8"/>
    <dbReference type="GeneID" id="28869112"/>
    <dbReference type="KEGG" id="chig:CH63R_10031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10031"/>
    <dbReference type="eggNOG" id="ENOG502RA7Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704003_0_0_1"/>
    <dbReference type="OrthoDB" id="3539922at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="41772" checksum="E391411E81F5A00F" modified="2012-03-21" version="1">MSEPAAAAATAYDDFQRDLEPKEQPREHPESHKHRKDMGPGAHAAHSGPRQTRRNHKNRYYDDDNDDVFPSRARSHDRSAHRHRTADDRRNDFDTYTPASRHSRERQHAYHPPKTSETRRPKYTDFEADPRQTDYRRPRYADYDDVDMRTAEPHRSQYQQYGAEPRGSDRRQARQADYEDVPRGGGESYRGRYAGYEANARPQPRDYTPSGRGRFRNESSDRYTQPSSQQRPVRGRSMPRKGVKGVGPAGSARPRAKSAVGYAALGEAAQTAFRVGSQAALQMRSEPGPWIGEKGTRVATAALGAALVDTFVGHKATGMRGGMRHQALRQACEMGIRNFVIQPTVNTATRRSGAGGGDGYSSGGHGSSSRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPD0</accession>
    <name>H1VPD0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_12174</name>
        <name evidence="10" type="ORF">CH63R_07732</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02005130">
        <property type="protein sequence ID" value="CCF42084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157484.1">
        <property type="nucleotide sequence ID" value="XM_018302706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPD0"/>
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    <dbReference type="GeneID" id="28866813"/>
    <dbReference type="KEGG" id="chig:CH63R_07732"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07732"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000050">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF447">
        <property type="entry name" value="FK506-BINDING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF42084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="113" mass="12161" checksum="A1EC860C3376933E" modified="2012-03-21" version="1">MGVTKTTHNEGSGAIPKPGQTVTIEYTGYLKDTSKPDNKGSKFDSSVGRGDFVTRIGVGQVIKGWDEGVTQMKVGEKATLDITSDYAYGERGFTGHIPPNADLIFDVHLKNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPP2</accession>
    <name>H1VPP2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_12266</name>
        <name evidence="5" type="ORF">CH63R_04481</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005216">
        <property type="protein sequence ID" value="CCF42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160702.1">
        <property type="nucleotide sequence ID" value="XM_018299456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPP2"/>
    <dbReference type="STRING" id="759273.H1VPP2"/>
    <dbReference type="GeneID" id="28863563"/>
    <dbReference type="KEGG" id="chig:CH63R_04481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04481"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="407" mass="46132" checksum="D8796537F7046185" modified="2012-03-21" version="1">MAEPIRNKRLDPATAPTPQNTPLQNAPISSHAQQPGVASIKEEDFDRAAAASIFAQNPKLVQMIQGRLGSLVGRSSGYVESLPPQVRRRVAGLKGIQKEHSKLEAEFQEEVLQLEKKYFAKFTPLYEKRAKIVNGGSEPSEEEIKAGEEEDEEEDEIEEAEKDEKADKPAESSEPVSGIPEFWLSAMKNQISLAEMITDRDEAALKHLVDIRMEYLDKPGFRLIFEFAENEFFTNKTITKTYFYQNESGYGGDFIYDHAEGDKIEWKEGKDLTVRVESKKQRNKNTKQTRIVKKTVPTESFFNFFSPPQAPTDEDDDAASDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALAFEELDDDDLEGDYDDEDDEDEDDLSEGGDDDEESEDDDDTGKPKQEAAECKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSC6</accession>
    <name>H1VSC6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_03005</name>
        <name evidence="8" type="ORF">CH63R_03328</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005879">
        <property type="protein sequence ID" value="CCF43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163119.1">
        <property type="nucleotide sequence ID" value="XM_018298303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSC6"/>
    <dbReference type="STRING" id="759273.H1VSC6"/>
    <dbReference type="GeneID" id="28862410"/>
    <dbReference type="KEGG" id="chig:CH63R_03328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03328"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="498" mass="56960" checksum="B54B57B1A2CBA886" modified="2012-03-21" version="1">MSILECFKPVGKRKAKNGKRPLLPPGPPTRPLFGNLLQFKDSKGDPFHKQLLSLRDYGDMTTLHLGSKTLVFLNSNRVVSEIIAKRGSRTNERSPMPISNTLVDYGRKSLLLPQDQWAEPRRVMHSLLSGTALRQYGTWQELESTQMMAEYVIRPGAWYRHHYRYANSVIHRIALGERLVKTPEELVEMQNAVTFFVGSIGSSVIDWFPELDKLPRFLQFWRPHWEALGQWNLDLYSRWYNPIKNKVENGTAPPSFVRDVLLHPDTKFKGDDIDAMYVAMQLIEAGSDTTREALNIMTMAALEHPDVFQRAREEVDKVCGVDEEARLPTLADMDDLRYICAMAKEILRWRPIFPITPDHTASQDIEFEGYYFPAGTGFTVNGPAVSRDCDEPEEFKPERWLDGHETDIAHGLWAFGGGRRICVGYRLAQRSMFLNIARLVQCVDYRANGPYNSFVLNLEATDEPFPVKVMMRSAVYEALILREAEAAGVLEEARLFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSS6</accession>
    <name>H1VSS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_13035</name>
        <name evidence="4" type="ORF">CH63R_06199</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <accession>H1VUZ1</accession>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006579">
        <property type="protein sequence ID" value="CCF44050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
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                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007543">
        <property type="protein sequence ID" value="CCF45222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR07296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155814.1">
        <property type="nucleotide sequence ID" value="XM_018303791.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VYB0"/>
    <dbReference type="STRING" id="759273.H1VYB0"/>
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    <dbReference type="KEGG" id="chig:CH63R_08817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08817"/>
    <dbReference type="eggNOG" id="ENOG502RNK4">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1590:FF:000001">
        <property type="entry name" value="Tethering factor for nuclear proteasome STS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF45222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR07296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="277" mass="30284" checksum="DCEEEEEA4925FA98" modified="2012-03-21" version="1">MATTSRKRKADEDGDEMSLSPRSSPSASSRQLQRPSKKVRSNELVGRPLSLPRMLETLDPTAVRALLVRICERHPEIGQEVISSAPRPTVAAAHGVLQEYQEKMKAAIPYGETSADYTYYRVKAPLTALIDALLDFTPQYLPPNETQTTVSLQYLDGATKIIHALPDWEPQQYRHHKENAYDEISKAWALVINEAAKRGGGLSLHTGGWDQTLAKHHEISGGRMGTAMNSMATSVSWMAHGGSSNGQQPGNPSSDPNSILNQLMSGTYGAPVRVGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ57</accession>
    <name>H1VZ57_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_14573</name>
        <name evidence="15" type="ORF">CH63R_12006</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02007818">
        <property type="protein sequence ID" value="CCF45519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153821.1">
        <property type="nucleotide sequence ID" value="XM_018306980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ57"/>
    <dbReference type="STRING" id="759273.H1VZ57"/>
    <dbReference type="GeneID" id="28871087"/>
    <dbReference type="KEGG" id="chig:CH63R_12006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12006"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_0_1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
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        <property type="entry name" value="GH"/>
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    </dbReference>
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        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF51445">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitinase insertion domain"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="58"/>
            <end position="422"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF45519.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR05303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="449" mass="49599" checksum="78D76A02C11C903A" modified="2012-03-21" version="1">MHLARSTTIVTSAIVLLATLFLTHTYTDLFTRLSIPFFKANVTDTDTGTMGGGPGQGFRSVAYFVNWAIYARKHRPQDLPVENLTHILYAFANVRADSGEVHLTDGWADTDIHWEGDSWNDAGTNLYGCLKQLNLLKRRNRNLKVLLSVGGWTYSSNFKGPASTPEGRETFARSCVDLIKNLGFDGIDIDWEYPQTPQEASDFVALLQAVRSAMDQYASTLPEWYHFELTVACPAGAQNYQKLDLPAMDALLDFWNLMAYDYAGSWDSVAGHQANLQPCQANPRSTPFSTAAALAHYTAHGVAPDKIVLGMPLYGRAFENTDGPGTPYSGVGEGSWENGVFDYKVLPLPGSQEYHDEETGASYSYDAGQRKMVTYDTVHMARRKAEYVRGWGLGGAMWWESSADKPGPESLIGNVVHTLGGPHGLARSDNCITYPESRYDNLRNGFEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1W072</accession>
    <name>H1W072_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mold-specific m46 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_14814</name>
        <name evidence="3" type="ORF">CH63R_10804</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008136">
        <property type="protein sequence ID" value="CCF45884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155202.1">
        <property type="nucleotide sequence ID" value="XM_018305778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W072"/>
    <dbReference type="GeneID" id="28869885"/>
    <dbReference type="KEGG" id="chig:CH63R_10804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10804"/>
    <dbReference type="eggNOG" id="ENOG502STSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156724_0_0_1"/>
    <dbReference type="OrthoDB" id="5394791at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555722" evidence="1">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="106" mass="10878" checksum="0E58712D5510E17C" modified="2012-03-21" version="1">MQLRDLTALLFLALSTARASSVQAREAIPAELSARACTYNGCQCVSGLAQGVYCGNCVVGAGTYAIKTKRVRTHAFECSPGGGCCSYGAASDCGTSRARCRSGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1W147</accession>
    <name>H1W147_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CH063_00598</name>
        <name evidence="11" type="ORF">CH63R_13981</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Reinhardt R."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
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    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
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        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
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        <cofactor evidence="9">
            <name>Fe(2+)</name>
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        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
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    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="9">Nucleus</location>
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        <property type="match status" value="2"/>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
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    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="82"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        <ligand>
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            <position position="247"/>
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        <location>
            <position position="248"/>
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        <ligand>
            <name>Fe cation</name>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00000068"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="9">
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            <dbReference type="HAMAP-Rule" id="MF_03101"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF46210.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="OBR02755.1"/>
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    <evidence type="ECO:0000313" key="12">
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            <dbReference type="Proteomes" id="UP000007174"/>
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    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="342" mass="37345" checksum="AD531DCAA4220D5E" modified="2012-03-21" version="1">MSPSADLPETRETLEAIAAADQTKTISELRKTVTSETTPLPLRFRALFSLKHVACNNKGPDSDAAIEAIAAGFASPSALLKHELAYCLGQTANLVAVPYLRDVLCDLKEDPMCRHEAAEALGALGDASQLDILREYRDREGEDVCITETCEIAIDRIEWENSEQRKLEKLRKSDFTSVDPAPPMEESQRSVEELEKTLMDAKLPLFQRYRAMFALRDLASPPDLPTAVPAVLALARGLADPSALFRHEIAFVFGQLSHPASIPALTEALSNTEEASMVRHEAAEALGSLGDEEGVEETLLKFLHDKEKVVRESVIVALDMAEFESSGQTEYALIPDAAKAAA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1N2</accession>
    <name>H1W1N2_COLHI</name>
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        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
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    <gene>
        <name evidence="10" type="ORF">CH063_03861</name>
        <name evidence="11" type="ORF">CH63R_05813</name>
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    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
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    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02008656">
        <property type="protein sequence ID" value="CCF46395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158638.1">
        <property type="nucleotide sequence ID" value="XM_018300788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1N2"/>
    <dbReference type="STRING" id="759273.H1W1N2"/>
    <dbReference type="GeneID" id="28864895"/>
    <dbReference type="KEGG" id="chig:CH63R_05813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05813"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_0_1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF46395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="588" mass="67086" checksum="6BEA164485FE45AE" modified="2012-03-21" version="1">MVAKFQLRNYSPPTYRVLALLVVFVVLSVLLLRDESAQLNGDGDDDVVAPILEATKSSYDWSTHPQKHPVPLADMTRLPDGEPLSLPKIQFDFTADRSDSLKKRDVSLMSSRRHEVRKAFIKSWQSYTRYAWGYDELQPLSLRGRNRYNGWGVTLVDSLDTLWLMGMFDDFNKAVQYVSMIDWNNATESRCNVFETNIRYIGGLLSAYDLSNEKVLLDKAIQLADMLYAAFDTPNRFPPFAFSFVELKAGRILPDPYQSAAAIGSMSLEFTRLAQLTGEFKFYDAIERIKQAFDLIQEETMLPGLWPSFINVRDDFQATNNIFKLGGDGDSLYEYLPKMHVLLGGLDTSYERMYKGAARAAKAHLLYRPMTPQMDDILLLGTAIVNEKLRKIDQISEIEHLSCFAGGMFAMAGKLFDIPDDVEVGDKLARGCAWAYKSFKSGLMPEKAQVVKCDTIDACAWDEQKWAAQSGQHAPRGFWRVDDAHYNLRPEGIESLFILYRITGREDLLDMAWDMFQAVQRATQTDDAHAVIVDVTYSQSRQEDTMESFFFAETLKYFYLIFSDSELISLDEWVFNTEAHPFKRPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1W363</accession>
    <name>H1W363_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_03994</name>
        <name evidence="13" type="ORF">CH63R_10125</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009190">
        <property type="protein sequence ID" value="CCF46926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154523.1">
        <property type="nucleotide sequence ID" value="XM_018305099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W363"/>
    <dbReference type="STRING" id="759273.H1W363"/>
    <dbReference type="GeneID" id="28869206"/>
    <dbReference type="KEGG" id="chig:CH63R_10125"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10125"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060603_0_0_1"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="90"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF46926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="285" mass="31275" checksum="735186BB5A2BBDA4" modified="2012-03-21" version="1">MTVKNVNVFVSTFAGLGLPSTLVLPVPSTTSLSDLRHQLDERLPATDNRLILTTVSNKEISASSTKPVSDLLSSLNDDFVSLRLSVPLCGGKGGFGSQLRAAGGRMSSKKKRNQGDANNSSRNLDGRRLRTVTEAKALAEYLAIKPEMEKKEKEKRRERWEQIVELAEKREDEIKNGGKGRLDGKWVEDKEESNERTREAVLAAMKAGKYKDNLLGTSHTSTGSEETDEAMSSEDENEEGGSSKESTPPSEPAKAPADKPRTFFGFDEDDEFMSSDEDDADGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4S3</accession>
    <name>H1W4S3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Duf647 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04176</name>
        <name evidence="9" type="ORF">CH63R_12429</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009778">
        <property type="protein sequence ID" value="CCF47486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151820.1">
        <property type="nucleotide sequence ID" value="XM_018307403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4S3"/>
    <dbReference type="GeneID" id="28871510"/>
    <dbReference type="KEGG" id="chig:CH63R_12429"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12429"/>
    <dbReference type="eggNOG" id="KOG4249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015325_5_1_1"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="60"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF47486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="478" mass="53014" checksum="D6908DB12E510D0C" modified="2012-03-21" version="1">MEGKDKEVLLIEERDGTGRIMCQWLHNPDSQKIAQLREPHNTKSSSAVTSSYAAGLFTNMNQILFDAFLPIGYPDSVTPDYIGYQAYDSLQAFFSTITGLLSNRAILQGLGVGDPNSSATYALLLTILKDGISRVATIAFAYRFGLVIEPECKRYRFLADIFNDSAFFLDLFSPYFDPWTKVAAIVLAEALRAMCGVAAGASKAALSKHFARRNNLSELNAKEASQETAIGLVGLLVGSIVVRFVEGREAVFVLMVFLVFVHLAMNYFGVRCVQLDTLNQQRATILFDHYAQTKRVLTPKQVAWRENIVFWSPVIKNLRGEIIAKIAFAKSYADAMTADVKSAGIRFVTLKVDVQPRKEEKLEAGFVLCVCEKNGFATVKIMLLDDRSSDKVNNVNTLMAWYYAILVARDRQLGTKTDTNTGTRKLLGAISVDEIDADNEDVKLGLEALRKAGWNIDDANLDAFAPRISMGYANKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQL3</accession>
    <name>A0A1B7XQL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150532.1">
        <property type="nucleotide sequence ID" value="XM_018309560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQL3"/>
    <dbReference type="GeneID" id="28873667"/>
    <dbReference type="KEGG" id="chig:CH63R_14586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14586"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="108" mass="11805" checksum="4CC9D816F81DB6B1" modified="2016-11-02" version="1">MVRMVAEEVYLNAKRDEARAAEAARDAAAGHAALASLQEAGRAARTAAAKAAPAASEGPAEEEEEEEEEEEEEEEEEEEEEEEEESDDSLGILDEEMLAILEHWESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQQ9</accession>
    <name>A0A1B7XQQ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150618.1">
        <property type="nucleotide sequence ID" value="XM_018309375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQQ9"/>
    <dbReference type="GeneID" id="28873482"/>
    <dbReference type="KEGG" id="chig:CH63R_14401"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14401"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="71" mass="7542" checksum="A1CBF63C2C3236CD" modified="2016-11-02" version="1">MSVAEANSPRKYGKKARMGTMGIVLKGAMVLLLRRRAPGGPGSFESNAVCFLKSNGSLVSSERVHESSEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRA9</accession>
    <name>A0A1B7XRA9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_13517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150809.1">
        <property type="nucleotide sequence ID" value="XM_018308491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRA9"/>
    <dbReference type="GeneID" id="28872598"/>
    <dbReference type="KEGG" id="chig:CH63R_13517"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13517"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="82"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="60404" checksum="EB949EEA5376529B" modified="2016-11-02" version="1">MASMQEGKPAISGSELNNAPLSSLGSSETSSVTEGMAVAVDEKSGRVLISSQEAKEANEAGDPDDADDADVEYPQGLRLVLIIFGLAMAVFLVFLDMTLIATAIPAITNQFNSLQHVGWYGSAYMLSLVYGKCFELFSLKWTFMVAIAFREVGLAVCGSAPNSVAFIVGRAITGIGCSGIIIGAWVVLAHCVPIRKRAVYTGFLGAFSGVGGIIGPLISGALTDSHLSWRWAFYVSIPLGVATLALICFCFRPPEQRDQDRNKTIKQKLMEFDVLGLSIFFACMICLLLALQWGGSEYPWNSGPMIGLLVAFGVLLVCFIGVQMWKGDKAALPPRLMKMRNVAFACFYAACIDAAYYTADIWLPIWFQAVKGESARESGIKLVPYVGGEVLAALTAGYLVTFTGWYNPFMLIATVLASIGLGLMTTFEIETGPSKWITYPIIAGIGVGLGSQQPMMGVQSTLALSDIPAGTAAVTLFQNLGPAILMSVANAVFANGLTKHLHGTGGFSGRTIADMGATNLKAMIPADLLPAVIEAYNKALKETFSVPMAVAVISIVGVVGMKWKKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSQ5</accession>
    <name>A0A1B7XSQ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151282.1">
        <property type="nucleotide sequence ID" value="XM_018308964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSQ5"/>
    <dbReference type="GeneID" id="28873071"/>
    <dbReference type="KEGG" id="chig:CH63R_13990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13990"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601032" evidence="5">
        <location>
            <begin position="19"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="843" mass="89892" checksum="D0E2555AA931CD07" modified="2016-11-02" version="1">MVFLRCAWLVAFAGLVAGQYDGWDLEKGQVSSEMCFWYSPRAAVIRDTLWLDGGRLYWTPTYRDGSEGPPETLDNPLGLMYSLNFSKPFDKTTNITTLIDTKSKALGGVGNANSLAPNTIDGALLHNDAEFFLYGGVLPKRTDAFDPPPGDKVMALRLHAYGPEKPSFQNGSGDNHDLGDDVTRYVAHGGAASAPSENKAWYVGGMRSPLWGEMYMSNPNRSLNAVNASNTLITLDMSEQLFEKFSNQSLPSIIRARANPEVVWVPVGAEGILVVLGGVTYPEYVNLSHKSEDAAKSQQESPAFMETIDIYDVAGNKWYQQKTEGIRPPALARGCAVLAPAQDYSSFSIYYYGGYDGISAQEDFSDDVWVLSIPSFQWTKVYEGRALHARAGHRCVMPYPDQMMVVGGYAAMPGRGNPPCLEGGIIQVFNLSSAEWLDGYSPSKWSNYTIPTAVVSKIGGDAKGSATKTQPEGSGWADPSLAAIFARPYETSKIQTWYPYTESKETTRPTIPEGGNGGGGGGGGGGGGGGTPKWVAPVLGVVLGLVFITAILVGFCLWRRRRVLRRGNGTATQTEDNGSRIISWIRGQPSEPAKAPTVTTEETLSNQDMAEVRTPPPAPAASPAPRHFVHEVADTQIIAELPDTSPRPELHGVGLTPVEIINKHTHFGTGQGSNVPNQSSYYASVSSNENASTLSRSSGVLGYQTRAQSPDPGPPSPSIGTAVVPAPTGGRVGSDVSGLSDRDAKHLRSLSEATVSSASSGGEQGGAGGGPTAREQQQQPRGVPTTVPETPTPGHPSPLSPPTGASDGEDYISARMLPVSPAGTATMRRSMFHENEDDLGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTI6</accession>
    <name>A0A1B7XTI6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome b5-like Heme/Steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151584.1">
        <property type="nucleotide sequence ID" value="XM_018309266.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873373"/>
    <dbReference type="KEGG" id="chig:CH63R_14292"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14292"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="619"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="939"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1312" mass="142303" checksum="C769B46A9F52F854" modified="2016-11-02" version="1">MSAFQSPPTPSPSPTPTLSTLSSSWKKPQQDVVKYTTPSSSLPPSPSLPPSPPPPTSPSSSSIFYNVPQTPTGGLVTPPEIPVVKSHDVTGKTSTSVIDCPISKASFLLAQVSLATGLFGGLPTTEVRFRGPGSLGAAASRTRTLRFGTGLDGCFTSTGGFLGRMRETHNEKHVTTVSRGNASARPGQQRLPPSLEAWEVVHENLPRLLRAGRVRQAVDALDEWRASEAGEGGGRDRWDDLEQRHLARAALVLSALAHAYMFGEDRGKHKGKGDNGGRPSQPSLPVHLLGPWERVCKKLGRPLTGRVPADDVLNNAVGDDSFSLTSAYFGLPEERLSSGLQGRMEAIFAPALSAMALAQSGVLADQPGLVARCLESVAARIVECADVFEAMTPRDTAHFDPVVWIKSYPAMGRPVTSGELGNSGVDAPLFHALDAFINRQHVEGDLKRMQGDRRATLPANIRAFLDALDDEAASVRKYVAAADVAVRAQRRRRQHYYHHQYLPSGEEVEEKEEEKEEEEEEEEEEQSQYRHLSAAWDGLLQTYVWFLERHRVKAVGVTGVSLNTGRHSTSSGVESGDQDKAAVAAAAAAAAAGPPKMRPETMLSMQMKKGMASRLGGRPLWQDARVQSQTVYEGSVVVAVRLDANLPLKPGDRVQVWPPARKRKKANNSSWHHHHHRHSRCPQGSSSPEYHDDDDDASSSNESDYDDDADVEPRFYSIARAIPDVADDRMTDLGAGGGEGGGRGQGMTITLTVGQHSPEGLVSSFLSTAAPGTHLRLRPWPSPRFRQPRNLAVPLVLVGQGSGVGPFVGFLHDRVAWAQRRLRHRDDAQQDDMVEKEDEDEELGEVLLVVAAKTRRHVPCPLDSLEQLTRALPLTIILALSEEEHHLMIRSGTWTQLPTGDRHITRHLLEHRDFVQRLVKEKGGHVFVCGSSDFGATAMSSLGLGQPQQQHQEQEPQQQQAQYPHGVSYSYNDNHTHMPSAPPHWNQLHQDLFVTVKRPSSTSPTSPRFSSSSSSYSYSSSSSSSSSSSHVYASPSSPSLDPRNTIITPSSLAAHNSINSCWTAIGGTVYDMTSFLAMHPGGPKTILESAGTIADARFAETHGGPHAQEIKGYLQRYAIGRLSTSATGPVTQTTSAKLTSVLVRMQNALTNNSAFDASRGPLPLYVYEDALLVFADSLDGVVGILSDAAVGKQSSEQRAAVLKTQALLRKAFTLLKTGCKGCLFAAGSESSSSTLLEESEALVQRLYREPIKKVHAAVDACKRGLSEIETETEADSDDKICDAQNDENDDALKRVLEKFCTNLASIAEDLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU45</accession>
    <name>A0A1B7XU45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151786.1">
        <property type="nucleotide sequence ID" value="XM_018307369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU45"/>
    <dbReference type="GeneID" id="28871476"/>
    <dbReference type="KEGG" id="chig:CH63R_12395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12395"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="398" mass="44796" checksum="A85EA02E359A3C21" modified="2016-11-02" version="1">MADTPGMAALHPGELDEAVEVDEGFVVGQTQTAYTDESQLTMASPSRTMGLLWMIKCTVARYTLSLSSSVVDYPEEYGRRYHAFRPGTYAFPNDEVELTRLDMAHALMVRAMGNRLYLAPLERDKVHRILDIGTGTGILLMIVVFFQGAIEMGDIFQNAEVIGNDLSAIQPEWVPSNVKFEIDDVESPWVGHKKFDYIMCRYMACSIGDWPSLIETIYDHLNPGGWAEFQDMSTEYYSDDGTYTARHATYAWNQTFVRTLRAVGRDPCPGPQLEGWVRAHGGFGRVSHHRFKTPIGPWARDAHFRGQGMLNLAQILEGLEGFSMKLFCGVLGWPEDKVHAHLAAVRHELKCGAFHAMLDLWMIPLPLFSRGGVVWLIARRRHTVYGQKPPRPDSPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUA6</accession>
    <name>A0A1B7XUA6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF862-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151867.1">
        <property type="nucleotide sequence ID" value="XM_018307450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUA6"/>
    <dbReference type="GeneID" id="28871557"/>
    <dbReference type="KEGG" id="chig:CH63R_12476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12476"/>
    <dbReference type="OrthoDB" id="3431913at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41831" checksum="1EFD888F99797FFB" modified="2016-11-02" version="1">MSQPGSDEEAKRKRDKVGEFLKKNLTKGELAVKHALGLGATPNVVPVTQPVLNGPPRVVEVGWHPVGGLAGKWFAEETGLGKMITEKINKYPDPTQHWAVLVGDFAHQLWMVSLIYPSPSLPPPPCPAPASFFLVAALTRYTKQDEDFHVIYTNERYKRDEWRTFTVGETRFNDDAIRRAGEYVIQSIRSRQPVYNLITNNCQTYVLELLDAVKVDGQKDFGTTLAVYERLFSSGKVIDLFSEEQKQEQQQQQLLLEAPPQQYPPLPPSLASPHTYSPPPPGQHLYPPPSFGLPPPQNAPMPPQYQYGLPPAPMPPPPPPRPAGPPAGPRPGTVSHAQQVMNDNTTQLDTQEEASKTRGHKKEPKRGFFSRFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUM8</accession>
    <name>A0A1B7XUM8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151966.1">
        <property type="nucleotide sequence ID" value="XM_018307549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUM8"/>
    <dbReference type="GeneID" id="28871656"/>
    <dbReference type="KEGG" id="chig:CH63R_12575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12575"/>
    <dbReference type="OrthoDB" id="4848575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601103" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="4278DE24DAFF3FE6" modified="2016-11-02" version="1">MHFLKSLLVATLFALGVSTAIAEEPDALDSRSTLEACAPLWDVALSLRDQFLAKRATVDPLGLESYDRFVGYYSSGMYNMLEACGTLQSFKWPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV77</accession>
    <name>A0A1B7XV77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152162.1">
        <property type="nucleotide sequence ID" value="XM_018307745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV77"/>
    <dbReference type="GeneID" id="28871852"/>
    <dbReference type="KEGG" id="chig:CH63R_12771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12771"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="106" mass="11891" checksum="E6C5AC2316DEA206" modified="2016-11-02" version="1">MWNTTWVNRAVYERLADGTSTVPDAGHFIRVNDMDGRRAQTEVRRDAGSFPHDSDEEMMKDTGIIPITSVMSKVAFRRDTIIQEGKAVQRTSNLGSLQNLTGHKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWD1</accession>
    <name>A0A1B7XWD1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152582.1">
        <property type="nucleotide sequence ID" value="XM_018308165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWD1"/>
    <dbReference type="GeneID" id="28872272"/>
    <dbReference type="KEGG" id="chig:CH63R_13191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13191"/>
    <dbReference type="OrthoDB" id="4802527at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="239" mass="28644" checksum="205CF268D26729D1" modified="2016-11-02" version="1">MLTFHCFPLLPVELRQRIWMLSMEPRQIVYGKEPPSYYQCPWPASAPPPPLLHTCDESRAQLKRHYVKAFVTEKAPEKYTWVNFDIDTVYLAQHNLKNLHAECPMVRKIILLGIDSEMFFHFYHGLLWGMKHLETVDILHMESPGKVDDEWWTGWDSMMEAYYFRDDPVPFYTRILYPQYPPYEINADNYLKVERDKRRKLLAEHPDWYEPGYEISDDDDDDVCGPNRFRTGYRRRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWP9</accession>
    <name>A0A1B7XWP9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_13323</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152714.1">
        <property type="nucleotide sequence ID" value="XM_018308297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWP9"/>
    <dbReference type="GeneID" id="28872404"/>
    <dbReference type="KEGG" id="chig:CH63R_13323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13323"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="87"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="535" mass="58523" checksum="9C5BDCF2003BD1E6" modified="2016-11-02" version="1">MDKDLRQPEPATSDKGTSELAFARADVETGGTTGLSAWFGGRKTKVGPRIAPRREGLGDTSDSEENPDAILGKQLAEEDGHAIKYRTCSWQKTAGLLFSEYICLAIMSFPWSYSILGLVPGLILTAVIALIVLYTSLVLWQFCLRHPEVRDVCDIGQMLFWGKKWAWYATAVMFILNNTVSRSLFIQALHVLVGAKYLNTMTESDPVVCRTVVFSIVVTIICWVCSLPRTFNSLSKAGTASAVFTFISVLLATIFAGIQSHPAGYDPRSTYVGDNGVTKTGGNPIVTALPLASTTFVSGMNAFLNISYTFIGQITLPSFIAEMKDPRDFPKALWAVTIGEIIVFSIVGAVVYAFVGNQYMTAPAFGSLEDVYKKVSFSFMIPTLVFLGVLYASVSARFLFFRLFKGTKHLHEHTIVGWGSWATILLALWLLAFLIAELIPFFSSLLSLMSSLFDSFFGFVFWGVAYFRMRSADARAGIPRGNKLVDWASMALNIIIILTGLLFLTAGTYASVEGIIKEFRAGTVGKPFGCASNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWY1</accession>
    <name>A0A1B7XWY1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152801.1">
        <property type="nucleotide sequence ID" value="XM_018308384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWY1"/>
    <dbReference type="GeneID" id="28872491"/>
    <dbReference type="KEGG" id="chig:CH63R_13410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13410"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005127">
        <property type="entry name" value="PRK06565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF11">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="683" mass="73955" checksum="202DDC950669BD1E" modified="2016-11-02" version="1">MGVTQPLDITQASIGQILHALSTTKLTAVDLVARFLHRVGKLDHRGPCFNSICILNPNVFDEAQASDDYRASGRPPRALEGIPFTVKDSYQVKGLTVAAASPAFENLVASSDAAVVELLRAAGAVLIGKTNMPPMADGGSQRGLYGRSSSPYNPVYLCTSFASGSSYGSGVATTASFAPIGLGGETVSSGRAPASHNALVGYSPSRGVIPSRGHWPLYPTCDVVAPHTKSVADMLALLSVIVADDGEPKGDFWREQTVVPIPLSSEVRPKDFSSLMDPDALRGKHVAVPRCYIGKQASSGYSVVCSEATQSLWEQARIDLEVLGAKVTETDFPLAENYSKQLYPGQAANIPGIPSTWIDTERCQMIATAWDDFLRYNNDPSCSRLEGVDHRQINPDLAPMDNRSEHTEEQNHVRYADMLDFIQHRPSSIRDLPGCADALLALEDARKRDLDDWMDANGFDAVVFPTNGDVGRADSEHNREAMVEALQDGVKYSNGNRALKHLGVPAITVPMGILADKEMPVGLTFVGKAWSDSELFRYAYAYETATSRRKSPPLAPRLMTDVIRSERGSMKGTEKLELVVAQVDVKAVTTESSEVRKVVIRGSLVLGSAALDTEGIRVYVNGDLSSRPPTLTDGQWEWAGQLGREKVKDPYLVPGKLARDQFMVVMVARTSTGRSTGRLIMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXQ1</accession>
    <name>A0A1B7XXQ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153071.1">
        <property type="nucleotide sequence ID" value="XM_018306230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXQ1"/>
    <dbReference type="GeneID" id="28870337"/>
    <dbReference type="KEGG" id="chig:CH63R_11256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11256"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="7248" checksum="26627601D4215D96" modified="2016-11-02" version="1">MPARVRDGAAGDSIANYYKASTGFNCDISFEDSISSTGLQDGHVSKNSGGEGHGQARHPKDNGHNNVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY29</accession>
    <name>A0A1B7XY29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjfJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0145 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153159.1">
        <property type="nucleotide sequence ID" value="XM_018306318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY29"/>
    <dbReference type="GeneID" id="28870425"/>
    <dbReference type="KEGG" id="chig:CH63R_11344"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11344"/>
    <dbReference type="OrthoDB" id="68104at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.70">
        <property type="entry name" value="Hypothetical protein apc22750. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145_YbjQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068:SF2">
        <property type="entry name" value="UPF0145 PROTEIN SCO3412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="UPF0145 PROTEIN YBJQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="YbjQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="163" mass="17437" checksum="14BE9485EFF59C08" modified="2016-11-02" version="1">MSFMGRKSDAKSEDVAHVPPELSDLHCFTETGGVITTRNIFGQIDAHTPAAMFDIPGYRVVRTLGAVYGLSVRSRNIAASLGMVIKSLAGGELRWFTTMLYNCRNDALGRVVSECKQRGGNAIICLRFDAADLGGFAQTCAYGTACVVEKIDEDAAVAPQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ77</accession>
    <name>A0A1B7XZ77_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_11768</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153583.1">
        <property type="nucleotide sequence ID" value="XM_018306742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ77"/>
    <dbReference type="GeneID" id="28870849"/>
    <dbReference type="KEGG" id="chig:CH63R_11768"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11768"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR05065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="41158" checksum="F8747ADCE5409E0A" modified="2016-11-02" version="1">MLSSRASTRLCVPKQAAHLARAASLHNISTTSFVGYYHPAAGLRISAVASLQPGSSGSRSFSTTPATRLRDFFPAKETEHIRRTAPAWPHPGYTEQQMHDIVPDHREPRSFGDWAAWKFVRLARWCMDRATGLGKDQQVDKKNMTTSLVADKPLTEAQWLVRFIFLESIAGVPGMVAGMLRHLGSLRRMKRDNGWIESLLEESFNERMHLLTFMKMSEPGWFMKLMILGAQGVFFNGMFLSYLIAPKITHRFVGYLEEEAVHTYTRCLYEIDLGLLPKWSDPNFTIPDIAVQYWRIPEGKRTMKDLIMYIRADEAVHRGVNHTLGNLNQKEDPNPFVSEYKDGEKPNAALRSQGFEREEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZJ4</accession>
    <name>A0A1B7XZJ4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_11888</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153703.1">
        <property type="nucleotide sequence ID" value="XM_018306862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZJ4"/>
    <dbReference type="GeneID" id="28870969"/>
    <dbReference type="KEGG" id="chig:CH63R_11888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11888"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR05185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="558" mass="61653" checksum="3A28D203D943F19D" modified="2016-11-02" version="1">MTTGYPRFFIHRSIVALADDLVSQYARSGQQAMLFPTPRSARRCLAFVKKHAEASITADVCVLDFGLDTSKDVSLLLRSLAPTVSAIVYGPEVFPVAKQYWQHTGDGVSSRRAEFCHGLLKEGLLVPAEPPQSPVGKACRGPKRYHRPSSIDDTKAASHHLATKATSQSASETQESLRFLEERFGRNLDLSLVERARSAIKRRIAGAMAVDMESSISSLPPMGDNSRNQKDLQESDVYLFPCGMNAIYNAHRAMLRARGDMKSVSFGFPYVDTLKILQKFGPGCVFYGHASEADLDDLEKRLEAGERFLALLCEFPGNPLLTCPNLARIRSLADKYGFGVVIDETIGSFINIDVLQYADIVVSSLTKIFSGDCNVMGGSAILNPSGRYYQSLKNAWAEDLEDTYWPEDIVFMERNSRDFASRIERINTNSESICDILSAHPLVKRVFYPKVNPTRPNYELCKLPGGGYGGLLSVTFHKKAQAIAFFDAIETAKGPSLGTNFTLTSPYVLLAHYQELDWAASLGVDPDLIRVSVGLEETDELREIFTQALEAAEKQTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZL3</accession>
    <name>A0A1B7XZL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153735.1">
        <property type="nucleotide sequence ID" value="XM_018306894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZL3"/>
    <dbReference type="GeneID" id="28871001"/>
    <dbReference type="KEGG" id="chig:CH63R_11920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11920"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601217" evidence="3">
        <location>
            <begin position="23"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="331"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="619" mass="67943" checksum="B7282AC199BE76CD" modified="2016-11-02" version="1">MNLGIKQLVVVVALGIVPLALAHSAQEDGANIMNMDMDTSRGADEPNKPDTDSYPPTYFALADHAGVMYAHIGTMVLAWVFVLPVAVMLSIARSRYTLALQFVFLAVNALGVLLGMVYNAATPDLYPNNAHHKLGWLVTWIVSVQVLIGFLGMAAGVLKGESPGEYDHNECQSFIPISTTAMAEHHRIHGSPFASEYRLSNDSGQGTEPCTESLRSHSRSSSSNEASPRISGDHQKEFIEDDQDHEDGPSMPMPSSSSNQKKANTILAKVAAKISLRVWRGLLYIYNLVDRIVLPLGSITLCLGIVAYGRFFVSDKNLNTPVEPKADLSQEGNGIFSGLAHWVKGGIFFWLGLLTLGRWTGSFGEIGWAWNVRPKRDDSKWRPSAEFVESALIFVYGSTNIFLEHLGNWGGEYSAQDLEHISITVLFIGGGLVGMLIESSRVRDFLNTSVIDAAAVAPERTYDDEERNTLQPPRQYSFSINPIPALVILLLGFMMSSHTQHSMTSSMVHKQWGNLLTGASFARGFTYVIMYLKPPTSVLPSRPPTELLAAFGLISGGIIFMASASDTIQGMEHYNLDAMFMYTVTMGLVGLLMAWEIIVLAIKGWAVRKEAGRLMYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y021</accession>
    <name>A0A1B7Y021_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153858.1">
        <property type="nucleotide sequence ID" value="XM_018307017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y021"/>
    <dbReference type="GeneID" id="28871124"/>
    <dbReference type="KEGG" id="chig:CH63R_12043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12043"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="30115" checksum="0D67F028946D12F9" modified="2016-11-02" version="1">MGSCCSTSDNSSQHELDQQPRPAQPPPSNMPPARDHVVSLDKKWAYHAVDGYELNNNTWGLESATSGSQRTHYDGPSPPGASGAVGIAWSTDWEWQGGEHNVKSYVYGARQFERRLLSDIRALPTEAEWHYSTWDVRANVAYDIFTDPDKDHANSSGEFEVMIWLAKLGGVWPISESKAPIAHVDICGHQWEVHFGYNHGGAMKVYSFLPVNGPIQHFSADVKQFFDFLSHQFQFPQHNQYMLVYQLGTEAFTGGPAEFVVPKFIADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y081</accession>
    <name>A0A1B7Y081_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153944.1">
        <property type="nucleotide sequence ID" value="XM_018307103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871210"/>
    <dbReference type="KEGG" id="chig:CH63R_12129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12129"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1188"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1264"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="140"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="847"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1507" mass="164688" checksum="1E618FC117CFABB6" modified="2016-11-02" version="1">MQPNHISHDTKPRQEGMENNEKVPTEQSQAELSTMEKEVEHLARQLSTSHSSPASNPSLDVTNNPLSPTPGSNLDPSSPTFDARAWVAAFVELTESDPASAPPRALGVAFRGLNVFGWSTGAEFQKSVGNVLLSIGKTLARLATGRRRRGRRVDILRDFEGVIEKGEMLLVLGPPGSGCSTLLRTLSAQTADLELGPETYLNYRGIDQKLIRTALRGDVLYNAELDTHLAHLTVAETLAFASHARSVRYVPAGFSHAQLALAHRDVAMATFGLTHAADTRVGDDVVRGVSGGERKRVSIAEASLTRARFQCWDNSTRGLDSANAVAFCRALRLQADLLGVSSAVSLYQAPQSAFDLFDRVTVVYEGRQVFFGGRADARAYFEELGFRCPERQTVPDFLTSMTSPHERRARPGFEDLVPRTPDEFAQRWKKSGQRQELLRELAAYEEKHPSGERLAEYQRSRRAEQAKTQRPGSPHTISYGQQVSLAFWRAWRRLLADPAFTIASLLFNLVMALILGSMFYALPADTSSFYARGGLLFFALMFNAFGSQLEVLTIYAERPVVEKHVRRYALHRPSAQAVASYLCDLPYKLANMLVFNVLVYFMANLRRAPAAFFFFCLVTLLATLAQSAMFRALASVTRSPDQAMIPSALLGLGLMIYTGFTVPVADMPRWSRWMARVNPLAYSFEALMANEFHGREFGCAAMVPRGPGYADLPPGSQICSVVGAEPGSSVVSGDRYLALAFGYRDAHRWRNVGVLCAFTVVFFAAYLFAAEHARPAKTRGEVLVFRRGEVESGLGPGKTGTTSPDGDVEAQGQGVSPPVSAVEEDGMFDENSDGGGGGGLTASNSVFHWEDVCYDIKVKGGTERRLLDHIDGWVTPGKSTVLMGVSGAGKTTLLDVLASRVSIGVVSGETLINGTPTDATSFQHQVGYVQQQDLHLETATVREALQFSAVLRQPASTPRHEKLRYVEHVIDALEMRAFAGAVVGVPGEGLNVEQRKRLTIGVELAARPRLLVFLDEPTSGLDAQTSWAVSVLIKRLAASGQAVLCTIHQPSAMLFGQFDRLLLIAPGGKTVYFGDIGESSSTLIDYLERNGAPAIEAEANPAEWMLQAISPPRDGSKATDWHAIWRSSPEYRDVKTELCRLRSLASCPSRSAPPADRSSQHQEFVSSFSVQFREVLVRTLKHFWRSPVYIWSKIALVVLSSLYLGFSYTATTSIQGLQNQLWAVFLLLVLFLNLNEQIMPVFVPQRVLHESRERPSGTYRWQTYLLANILAELLWNSAAALLMFSCWYPAVGFPRATPSSDPDRPTRALLVLLFLWAYLLLTSTLAHLAIFCIDLPETAGVLTSLLWMLCILACGVGVPRADLPAFWTFMHRVSPATYLVGGITSAAVPSVDVVCAEAEVLRVALPASGLGSGSDATCGGFLGPFAEAAGGRVLNPAAAGDGAGSVCEYCPLGTTGDFLARFDIAYGTRWRDLGIVWAYVLFNIAAAMALYWLFRVPKGKRAKVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y089</accession>
    <name>A0A1B7Y089_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neutral protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_12130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153945.1">
        <property type="nucleotide sequence ID" value="XM_018307104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y089"/>
    <dbReference type="GeneID" id="28871211"/>
    <dbReference type="KEGG" id="chig:CH63R_12130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12130"/>
    <dbReference type="OrthoDB" id="4811013at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601234" evidence="8">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="138"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32711" checksum="3CB0AD701BC4E109" modified="2016-11-02" version="1">MKNKIKKRHFYVPFFLICQIVLVHCAFDPPQSLQKKTGIAIVAGDAAKDSRFFCNRQQAAVIENAIKWMNRYSESAYSFLLDDDSRTSAAFIGWLGDRNIERSTSIRTEILHPIYRLSSQTRPYASALAELEDTVVIGCGTPEIASPCREPETIAFARSRSSTVVVCPVAFSNNGYFGTDAAEQATMSAWRTRRTYSPSAGLSLLHEMTHLKDVVGGFGDWPPKYGRSVDVTYAPSKCIALSSSKKIANAQNYMLFALEVKANLENASKKVAAGVPNKWQDATRLLRAGVGGRAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0C4</accession>
    <name>A0A1B7Y0C4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153981.1">
        <property type="nucleotide sequence ID" value="XM_018307140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0C4"/>
    <dbReference type="GeneID" id="28871247"/>
    <dbReference type="KEGG" id="chig:CH63R_12166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12166"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="16921" checksum="B51C23190E447160" modified="2016-11-02" version="1">MGSNPVPKYRIVVGSDEAGIKYKDAIKADLQKDSRVEFVEDVGSHETADKTAYPHRAAAAAQLVADGKADRALLICGTGLGMAIAANKVKGIRAVTAHDSFSVERSILSNDAQVLCMGERVIGLELARRLAKDWLGYAFDPTSQSAEKVHVIKALEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0E0</accession>
    <name>A0A1B7Y0E0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154006.1">
        <property type="nucleotide sequence ID" value="XM_018307165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0E0"/>
    <dbReference type="GeneID" id="28871272"/>
    <dbReference type="KEGG" id="chig:CH63R_12191"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12191"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601226" evidence="2">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="189" mass="20246" checksum="51F97B68A2DFB031" modified="2016-11-02" version="1">MIICRRRWAIFAQLATAATTNALQIISPPQSKTTPNILPPPIIRFPSLLRPSHPVSSSPFSPTPSAPSRVYPTYFPSAPCPAPEGRRVQTRPPFKDESSDLVADRPGLRSFPLPTTNPPCRAMSFEAEAVVLCPVPPGITSASLPQPDGRHLAVWGVLARGGCVDHDTERRDAAHGGMSAVKAQTSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1K1</accession>
    <name>A0A1B7Y1K1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154412.1">
        <property type="nucleotide sequence ID" value="XM_018304988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1K1"/>
    <dbReference type="GeneID" id="28869095"/>
    <dbReference type="KEGG" id="chig:CH63R_10014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10014"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="39023" checksum="85B9B0C839C03B3A" modified="2016-11-02" version="1">MLSLLRTLSYSKLPRPRLSLSEYTRRHLRTPTTHSRTSKMASQTFKLNSGYEIPAVALGTWQSAPGEVKDAVSYAIKIGYKAIDGAYCYANEDEVGEGLKQAFADGVKREDIFVVTKLWATYTIGDDKVKEGLEKSLKSLGLDYVDLFLVHWPVAMNPNGNHDRFPTKPDGSRDIIHSHSHVDTWKSVEKLLDTGKVRSIGVCNYSVKYLEELLPQAKVVPAVNQIENHPSLPQQEIVDYCKDKGIHIMAYSPLGSTGGPLLTADPVVKIAEKRGVTPSTVLLSYHVARGSTVIAKSVTPARIKANLEIVKLDDEDLKELRAYSDDLTAKKELKRYVYPPFGIDFGFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2G5</accession>
    <name>A0A1B7Y2G5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154715.1">
        <property type="nucleotide sequence ID" value="XM_018305291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2G5"/>
    <dbReference type="GeneID" id="28869398"/>
    <dbReference type="KEGG" id="chig:CH63R_10317"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10317"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="82" mass="8978" checksum="564CD9E04F583A28" modified="2016-11-02" version="1">MLAGSRGETSTWPQTYYLSSKVIEMKVRELTWAIYVARDELEGNFGIMSAVANSPLPAKGQKSGRASTMGCVKATKPSRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4L1</accession>
    <name>A0A1B7Y4L1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155497.1">
        <property type="nucleotide sequence ID" value="XM_018303474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4L1"/>
    <dbReference type="GeneID" id="28867581"/>
    <dbReference type="KEGG" id="chig:CH63R_08500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08500"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="170" mass="19174" checksum="8AFA2F11CC32FB44" modified="2016-11-02" version="1">MLTRGESGSGMPPRRRLIVQLVPVACTGAHGRQLNRIHHRAWNGSHGEWRLASPLTCSRGEQSSSEPVGTRSNPPSSGILELELELEWTEGGKAKLSSLPYKEYKYRQVGRGEGNASHPITGQSSRERGRSVWALDFHFHYRYVRVRPKGEWQPVRVRPKGEWQPVRGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5L5</accession>
    <name>A0A1B7Y5L5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_08813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155810.1">
        <property type="nucleotide sequence ID" value="XM_018303787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5L5"/>
    <dbReference type="GeneID" id="28867894"/>
    <dbReference type="KEGG" id="chig:CH63R_08813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08813"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42849:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="301" mass="31709" checksum="F748F292591657E9" modified="2016-11-02" version="1">MAPSELKGVLVALITPFTPDQKSIDTAALDAHIQRLIAAGVHGLVPGGSTGEFTTLSPEERKLLVEQTVKSAAGRVPVVAGIGDLSTARAVEHAVHAASVGASALMVVPPFYDAPNLTQLRELLGEIHDESGLPIVYYNIPSASGVSLSPAEIAGLSEVGVTHLKDTSGNAPALTELLFSAASTSRVTTFNGWDTLTFYGLAAGAKGSVWGATNIIPELSAELWTAVAEEGDLRKGRELWTKIFPICKFLESHNYASAVKTGMELRGWETGGLRKPFGLLEGEPRKEFARLLKDAGVDVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6A2</accession>
    <name>A0A1B7Y6A2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">INO80 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_09102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156099.1">
        <property type="nucleotide sequence ID" value="XM_018304076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6A2"/>
    <dbReference type="GeneID" id="28868183"/>
    <dbReference type="KEGG" id="chig:CH63R_09102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09102"/>
    <dbReference type="OrthoDB" id="4095124at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="3">
        <location>
            <begin position="128"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43574" checksum="06BEBCA3A2E940D3" modified="2016-11-02" version="1">MPSAMSDANGTITSREVKAEGYDTDDARTVEGKATYKSWKKKYRKMRITFDRKMHDCENLHRQESHALATAKRIAIENDRILDLLLDMNSSAQIPHDKRFHLAQDTPEESAFPPLDADVEPNPDEPTKSLKTLVNEVPHYTYSQAKEQYPTVVADMEPFSGEPDPPSFLTPDDIDDYIHDVDRRIDPDNLLPTLAPAARTNAPLPETNPHALSQSIAMKNPTSVYNWLRKHAPKTFLQDAENAAPADDEAVETPQTDGRKRRGGAHRGESTRGGRSRGGKRASLAAVRAEKAAQRAAEKAAAAAERAAALRRDADSYDHSMEDEDSDGLSFATPATGRGKRKRAGRDEDEGYRPRGSSSRPTKKKRKSEGADFGTPTVTKRGRKSEATRDRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6K9</accession>
    <name>A0A1B7Y6K9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156162.1">
        <property type="nucleotide sequence ID" value="XM_018304139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6K9"/>
    <dbReference type="GeneID" id="28868246"/>
    <dbReference type="KEGG" id="chig:CH63R_09165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09165"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="170"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="985" mass="109777" checksum="0BF7558FA7FFEB97" modified="2016-11-02" version="1">MGEPADTVSSSTNPFVNLAEISLSHDSQPDLILGPMASASTLPSPAVELSSGENSPYVFNGALDYIDDEFASGWTTPLASCVNCTAWGYQCEAAQEGESQSCCVPCTSLGCECSFLDTHPNFNDRAINDLMQSSRTSSTEAQGPPTTDVSKRPSGPFEPVTASTTSTPPPPKIGTRFSRDSTRILRQWLSSHNQHPYPSEEEKRILQHQTGLSKVQITNWLINARRRGKVQGRHRSTSPYSGNAETSTGPVNVPRRPGTPAPRSSPRYQSLNPLERWVDSPPEHEPATVTAIARAMASSHANSSVADDSYTTSFTDDEPPRSLYYTSSASSAGNSSGGSFASAYSHGSKNSAGIPRPVICSRARQRRRPKRTSLSNPRNQYQCTFCTETFRTKHDWQRHEKSLHMPLERWVCSPNGPRDIDPGTNQTCCVFCGEIDPSPAHIDSHNPSSCQERTFNRKDHLKQHMKLVHNAGLLDWSAKLWKITVPDIRSRCGFCGASLDTWSIRADHLADHFKMGSDMASWKGDWGFEDAVFDMVENSVPPCESPPPRSRPRLTQTEDLIEYERFSPFPYQASGTPPESPRNAYELLTLELNHFLRLFLDRTGNLPNNREIQLEACRIVFASEVSASEGHLGVECESWLRDLITSSEDITREARFGPIRSRTESMMSVLQIKGKYSLFEGCPCEAQLDGFVEARRDSGPNALSNQHLQSEACKIVTRLGKSWGLSPADLIDNWLVNLISSSTRWLSPFRSRKRLSQVEFSVGTSTQPQLVNGERAYTGIQVPLEVPRFQATSTVSNTQASFHDVAVVPFDEDSELGKSSTMAIDSPSSFQPENVNFRQHASTEPVSYHRDHETSPSMDILQPFESLSRPFLPATNMSWHRPGSTESDGRSLPTHLSTVKRNYAFFNDANFHRWLAQELRRWIAATMSPNNPNCHVPSDEEIQHQARFIVYEDGDPWNQTSADNHEWLRRFKNSIGMGTQEHLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6M9</accession>
    <name>A0A1B7Y6M9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein gyp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156177.1">
        <property type="nucleotide sequence ID" value="XM_018304154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6M9"/>
    <dbReference type="GeneID" id="28868261"/>
    <dbReference type="KEGG" id="chig:CH63R_09180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09180"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="314"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="639" mass="71690" checksum="7FED967D7A4FFC3A" modified="2016-11-02" version="1">MFSSSGSGKKPSQPQEMVQVGGFRHTFARLDARCSSRGSDLEHKLEYVPLRRPKGGSELTFGSSASPFWKPPPRENAPKRTGRDPNLVVGAAYSHADILKFDSLNLSNSSSRPKTPPSSHSTKGRPSDASPPSRPQSGLSSPPIKSYINFLSNTNDDWKADEDEEDMMGYEDDDGDDFGLPSLSNMKRRTRKMAAQNRPDANGGLSPMVDSFGGLGLHTRRYSNSADIAIERPAPTYPMPKKSEGKILRPQYKEILRDPANALHLIDHPAIPANATPKEIDAANSRITRINKFKKLLQASTIPLQELRQLAWSGVPQEVRAMTWQLLLSYLPTNSERRVATLERKRKEYLDGVRQAFERGGSVSGGGSSSSTAPPGKARGLDEAIWHQISIDVPRTNPHIELYSYEATQRSLERILYLWAVRHPASGYVQGINDLVTPFWQVFLSTYIADSNIESGMDPGQLPKPVLDAVEADSFWCLTKLLDGIQDHYIVAQPGIQRQVAALRDLTARIDAGLAKHLEKEHVEFIQFSFRWMNCLLMREISVRNTIRMWDTYLAEEQGFSEFHLYVCAAFLVKWSDKLVKMDFQEIMMFLQSLPTKSWTEKDIELLLSEAFIWQSLFKGSSAHLRGQPSRTPSVNMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6R6</accession>
    <name>A0A1B7Y6R6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156248.1">
        <property type="nucleotide sequence ID" value="XM_018304225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6R6"/>
    <dbReference type="GeneID" id="28868332"/>
    <dbReference type="KEGG" id="chig:CH63R_09251"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09251"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="78" mass="8341" checksum="29502688612F7687" modified="2016-11-02" version="1">MESRGLVRRRARDDNVLAARQRARSSTARHLDRLRSGQVGGGVASPNNSEMGSIGVIQDRNRQSRKKAAASSGSGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6W0</accession>
    <name>A0A1B7Y6W0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">CH63R_09301</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156298.1">
        <property type="nucleotide sequence ID" value="XM_018304275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6W0"/>
    <dbReference type="GeneID" id="28868382"/>
    <dbReference type="KEGG" id="chig:CH63R_09301"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09301"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="137"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="OBR07780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="34533" checksum="3E002184BD23AFF0" modified="2016-11-02" version="1">MSTTQAPPTTASPPEGAFPLPPLLTYPSSPAGSPVLITQGAEARLYRTTFLSPDLPAALKYRPRKPYRHPTLDARLTRARILAEARVLAKCRREGCPVPALYALDEAAGWLMLEWIPGAPVRVRINEWLDGIVGGGDAEGDAEGRGEVGGAGSVEAAARRRETQDAGDETAGRERRDAADLTGLMRRMGAAIGRMHKIGIVHGDLTTSNMMLRPPKPTSSSATTAAIPPTDDAAPSSPSSPLDGDVFIIDFGLASQSTSDEDRAVDLYVLERAFGSTHPRAEVYFRDVLDAYRDSYKQAPVTLRKLEDVRMRGRKRSMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y824</accession>
    <name>A0A1B7Y824_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156700.1">
        <property type="nucleotide sequence ID" value="XM_018301922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y824"/>
    <dbReference type="GeneID" id="28866029"/>
    <dbReference type="KEGG" id="chig:CH63R_06947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06947"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="43583" checksum="36AAE001F22F1F3E" modified="2016-11-02" version="1">MSNAMLRISSSCQRTTRHVRHVPSLIAAPSVRFGDHALRTKSASFHAAGRAGVPLIQKQPLVRQRSRSTKSAQPCSRGTIRHACCYTTVSMAPQPIIHDIFESKTGTWQYVVADPVTKAAVIIDPVLDYDRTTQVISTSSADGLLSLIKTNGYTVSRVLETHAHADHLTAASYLQNRLTRAHELVQGHMPPIGIGKRISQVQDLFIQRYGVPSEETQGVFDQLFNDDEEFAIGDLRATALHLPGHTPDHLGYKIGDNVFCGDSLFHVDIGTARCDFPGGSANNLFHSGRRLLSLPDHVKLWTGHDYPPKDRAQPVAWMTVRDHKKHNIHLRDSITEEEFVARRKRRDASLGEPKLLHQSLQTNIRAGRLPQPTASGHRMFRLPVKLNGLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y874</accession>
    <name>A0A1B7Y874_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156725.1">
        <property type="nucleotide sequence ID" value="XM_018301947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y874"/>
    <dbReference type="GeneID" id="28866054"/>
    <dbReference type="KEGG" id="chig:CH63R_06972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06972"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="239"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="480" mass="54868" checksum="045E69216D272EAC" modified="2016-11-02" version="1">MSDDEDFMQESDEEQYDFEYEEDDDEDSGDVGIENKYYNAKQLKLTDPEDAIAEFLGIPPLEEEKGEWGFKGLKQAIKLEFKLGQYEKSAVTRNYSEKSINNMLDYIEKGSDGPKAVACVEKFYSLTLESFQSTNNERLWLKTNIKLSKLLLDRKDYNTVTRKLRDLHRACQKEDGSDDPSKGTYSMEIYALEIQMHAETKNNKQLKRLYQRALKVRSAVPHPKIMGIIRECGGKMHMSEENWAEAQTDFFESFRNYDEAGSLQRIQVLKYLLLTTMLVKSTINPFDSQETKPYKQDPRITAMTDLVDAYQRDDVHAYENVLQKNQDILADPFIAENIDEVTRNMRTKGVVKLIAPYTRMKLVWIAKQLKISEPEVQDILGFLIVDGKIDGKIDQQAGTLEIQSDADSGRTKALYELTQSVSNLYTTVFKESDGFRSTDFPTDEQTMDMVGGGMTPRSGGPRGHPRGPGRKGKGVMPLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8H1</accession>
    <name>A0A1B7Y8H1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156854.1">
        <property type="nucleotide sequence ID" value="XM_018302076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8H1"/>
    <dbReference type="GeneID" id="28866183"/>
    <dbReference type="KEGG" id="chig:CH63R_07101"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07101"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="83"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="210"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="444"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="596" mass="65811" checksum="2C76F5D5FF82191B" modified="2016-11-02" version="1">MVVIKGVMQGVFGWLFSIQASLSQDKTNGKSPLGTLNAAKLPLFMKNNPLPNGFPWGGLTADGTNYYKQWPNTGVTRNYDFTISRGTIAPDGYERKVLLVNGAYPGPTIEANWGDWIEVKVTNNITDGPEGTSLHWHGFRQQNTQWEDGVPAISQCPIAPGKTYTYRFQATLYGTTWYHSHYSSQYAGGLLGPMVIYGPSKTQQEIDLGPVILSDWYHKQYFDLIEDILQVGGSGLVFSDNNLINGKGNFNCSTVAAGDNTKCTNNAGISKFKFQTGKTHRLRLINSGAEGTQRFSIDGHTLTVIANDFVPVEPYDTKVVTLGIGQRTDILVKANAGNNNPRGAYWMRSNITSCSLANQPLGLAAVYYDQADQSKAPTSTAWNVPDPGTCVNDDLAITKPVMKLKPAAPAVTKTMEIKLFRNASGIIQWSLDGEDFRGNFNKPTLLQANKGNLTFDADWNVENFASNGSIRVVVSNNSPAAHPMHLHGFNMYILHEGDGLTWDGTITNPENPQRRDVQLVRANGHMVMQFDSNENPGVWPFHCHIAWHASAGLFSQLLVQPDKVRQLQIPQKVADTCRDWQLWTQRNIPEVIDSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9S4</accession>
    <name>A0A1B7Y9S4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Onanonoxo-7-onima-8-eninoihtemlysoneda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157359.1">
        <property type="nucleotide sequence ID" value="XM_018302581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9S4"/>
    <dbReference type="GeneID" id="28866688"/>
    <dbReference type="KEGG" id="chig:CH63R_07606"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07606"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="810" mass="88406" checksum="274CE43BA88ECD8B" modified="2016-11-02" version="1">MAPVGALLWRSLRTYQIYGANTDVGKTVFASVLCNAARNLWPHEKTAFLKPVSTGPATEADDSHIQRFAPGIAKKTLFQFEIPASPHLAAAASDQVFASNSPVHRRHLLTTLAKHTPTDNEALQGIYDYSSRRAAKGPGWLFIETAGGVHSPAPSGTPQADLYAPLRVPVVFIGDAKLGGISQTISAFESLRLRGYDVESILLFRNDYYQNHAYLTDYFARDRGIPVATLDQPPARAEDANVDADAMARYYQEAASSNVIKATLDHLHDRHLTRISRLESMAHDAHDTIWYPFTQHKGLTPDKITAIDSAHGDNFQTLVPGSCAASEDRALLQPSFDGSSSWWTQGLGHANPKLTLAASYAAGRYGHVMFASAVHEPALALAQNLLKALQNPRLDRVFYSDNGSTGMEVAVKMGLRAARVRYGWAAGDRLEILGLRGSYHGDTMGAMDSTEPSVFNEKVEWYNGKGFWFDYPSIMCKDGRWQVRVPEALREELDEGREFATLSDVFDVSLREAAQEARSYERYIIKVLGRLRDQGRKFGALVMEPVILGAGGMIMADPLFQRTLVKVVRQHPELFGTSNQAPSTKKDAHGWTGLPVVFDEVFTGLTRLGRVSAASFLGVDPDVVVNAKLLTGGLVPLCTTCASDSIFRAFESDEKSDALLHGHSYTAHPVGCQVAVESLRELQRMDEGGAWDWAKAGGGWASDATPAWSVWSRPFVDWVSRRTGRVDGVWALGSVLAIHMQDSEGAGYSSTAAADLQSALLRGEGGAGEGARWNVHSRVLGNVLYVMTSQTTGQEDVQRLEGLLRKALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBI2</accession>
    <name>A0A1B7YBI2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157970.1">
        <property type="nucleotide sequence ID" value="XM_018303192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBI2"/>
    <dbReference type="GeneID" id="28867299"/>
    <dbReference type="KEGG" id="chig:CH63R_08218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08218"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="64" mass="7048" checksum="D8AD8EB61E06BF19" modified="2016-11-02" version="1">MCTRLLLGANVKLHDALLGIDINNQCQQPSLDHLCPFSFLRCAIMSCLTLYTHQAPAGEFGTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBK2</accession>
    <name>A0A1B7YBK2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157959.1">
        <property type="nucleotide sequence ID" value="XM_018303181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBK2"/>
    <dbReference type="GeneID" id="28867288"/>
    <dbReference type="KEGG" id="chig:CH63R_08207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08207"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="337" mass="37049" checksum="B577E42CAF1B1741" modified="2016-11-02" version="1">MSFTSVFHVKEHILDGSHIREFPRALSRSQDDVLKLAVKEYIPKDNPNPKPGDVTIIGAHANGFPKWSSNAKGTIESSPAAASARRRDLWPSRAAARAAFLKSPFYRAWDPRVFDAWLHHGLRDLPTQLYPTASPEADAAAAAAATSEKDRAVTLATTKHQEVFTYFRPSWDAYDAAGRELVRPDLVPDIDPGLNEGYFTFPVYRSEGASTLARLPQLRPRVLYVFGGDSDLSTPDLREEKMRLTGTGVGGSGGAARGRVREVTLPGAGHLFPMEVPGTSAELSAGWIEEALADWRAEQADYERWTRLSVAEKTTLTDEWIKRLGGSARPPKAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBZ4</accession>
    <name>A0A1B7YBZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158123.1">
        <property type="nucleotide sequence ID" value="XM_018303345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBZ4"/>
    <dbReference type="GeneID" id="28867452"/>
    <dbReference type="KEGG" id="chig:CH63R_08371"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08371"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="487" mass="51671" checksum="57290CE6C085BC48" modified="2016-11-02" version="1">MKSFESIGFPADVPLVVASTSTSADVSTNKPVDERPRTSLWCILAYSAPSMPVQAFFTMFTVYLIPYLTSELGFTVSQVSLVLLAGPLSGLTAAPVMGVLSDRSGRRLGLFTTGCVAMAACQVVLAWSRELAGGDPAAARWLSAVAVYLGCISARASIVGHRAMAIDNIPPRQQPVFNLASGLMSASGAITTLAVGLVKPSFRAITAICAVSITLSIFPLWAVRKPRRAHRRPAVRAESNRFGALSAVLSVPRAAWDAARHLPPRIRRTCKIQILSQYAWFPVSHYLSKYLQDSYVATRGEGSEAVAPEVSAQAGVRVLLIAEVGAVLLQMTVVRFWDASSTSASPLRRFMDEDMVALRRVWALAFAALGVSTLAAVLFRASFASASICAASIMTISPLSVWVPFTIISYEAAVVHGEKDGDPSTPGTSATFLSLHEMAITVGQSLAVLMSGVISFALEHMDTGARNTTAFLFPPAVAAAMVAALLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCI5</accession>
    <name>A0A1B7YCI5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Catalase-peroxidase</fullName>
            <shortName evidence="9">CP</shortName>
            <ecNumber evidence="9 10">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">katG</name>
        <name evidence="12" type="ORF">CH63R_08325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Confers resistance to H(2)O(2) in hyphae. May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9 10">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="9 10"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158077.1">
        <property type="nucleotide sequence ID" value="XM_018303299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCI5"/>
    <dbReference type="GeneID" id="28867406"/>
    <dbReference type="KEGG" id="chig:CH63R_08325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08325"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 9 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9 10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447766" description="Catalase-peroxidase" evidence="9 10">
        <location>
            <begin position="22"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="168"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-293)" evidence="9">
        <location>
            <begin position="134"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-134)" evidence="9">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="779" mass="84552" checksum="2C7E06D8764CA703" modified="2016-11-02" version="1" precursor="true">MHAKLSSCLLAASALLPAVAAEGCPFAKRDGSVSSELPKRETAAGFGRCSTISNQAGGGTRSQDWWPCQLRLDVLRQFQPTTNPYGDDFDYTEAFNSLDYDALKKDLHDLMTDSQEWWPADFGHYGGLFIRMAWHSAGTYRAIDGRGGGGMGQQRFAPLNSWPDNQNLDKARRLLWPIKAKYGNKISWADLMLLTGNVALESMGFTPLGFAAGRPDTWQADESVYWGGETTFVPNGNDVRYNGSTDINERADKLEKPLGATHMGLIYVNPEGPNASSDPAASAKDIRVAFDRMGMNDEETVALIAGGHAFGKTHGAVSGDNIGPEPEAADIGEMGLGWHNRVGDGNGVNQMTSGLEVTWTKTPTKWSNGFLESLLNNKWTLVTSPAGAHQWEAVNGTLDYPDPFDATKFRKATMLTSDLALINDPSYLNITTRWLDHPQELADAFAKAWFKLLHRDLGPVSRYLGPEIPKETFGWQDPLPAREGDLIDDADVAKLKADILAAPGLDVSKLASVAWASASTFRTSDKRGGANGARIALEPQVNWVSNNPKQLAEVLDALKKIQSAFNTGAKKVSLADLIVLGGSAAVEKAAKDAGVASASVPFVPGRVDATQEQTDVRAFSFLEPQADGFRNYGRGTARARTEEILVDKAAQLTLTAPELTVLVGGLRALGAVYDGSNTGVLTATKGKLTNDYFKNLLDISTTWTKAAADDAELWKGLDRKTKAEKWTATRADLVFGSHAELRAISEVYASADANDKFVRDFIAAWTKVMNLDRFDLKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDG8</accession>
    <name>A0A1B7YDG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IBR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158594.1">
        <property type="nucleotide sequence ID" value="XM_018300744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDG8"/>
    <dbReference type="GeneID" id="28864851"/>
    <dbReference type="KEGG" id="chig:CH63R_05769"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05769"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="38479" checksum="69C750EAA2CAF527" modified="2016-11-02" version="1">MEHFQRLDENIANIVIGHGFLNLDALQFATDEEVENAATLALQMAGPDVQLAIAIQQSGIPGGRRPPPNLDEIPGDPIPRQCITWEERNRLLADSRPNSAATSESDEANENNEQNCIVCSGGRQPKSRLPCGCWMCPPCLRACIRVGLRAGGWPPRCCEPLHQDQIESADRERPGLLSLYRQIREENETEGDDRVPVRERGEIYRQGQDPDEFPAVARLEHLGQPIPQVQPVPMPIPPPQPQLQPQAELFHPQAADGLWQPLPLARDEALETQSQSLPPQTSRGRARVAYLRDSTRRPPLQPPPPHVVGGRGHEQPGGAPAVWLLQVAGRSHLLPVSDVRDGDMQQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDJ9</accession>
    <name>A0A1B7YDJ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-coumarate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158718.1">
        <property type="nucleotide sequence ID" value="XM_018300868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDJ9"/>
    <dbReference type="GeneID" id="28864975"/>
    <dbReference type="KEGG" id="chig:CH63R_05893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05893"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="270"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="500"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="605" mass="66507" checksum="F7AE277066D0FBD6" modified="2016-11-02" version="1">MASDKASFADSRSRQLSIVHGPTSPPLFLKPLGSLIEDQAKKHANRLALVVPWQSTRLTYRELADRSKVTAKAMLEVGLHHGDCVGIIAGNCYQYIEIFLGASRIGCPFVVLNNAYSPEELKNAVTSSDCRLLFIAPQIGPKVLSSHLQAVLDVPPGNSRLKQIVCLQKFDNPNQGAICESYNAFFNRGQSIFMNDSVLKRAARKVRATDVLNLQFTSGKHLEYFRYLVARNANSRFTKAPRDCPRPQHSHTWSHKWFKGVLLQLILAPRNLINDAIFVGDAMRLTEVDIVCSPPPLFHCFGLVLGFLSSFCHGSSIVLPSDNFDARKALLAVVQEKATALLGVPTMFLAELEELDRSTLSVTTLRTGIISGSAVPSTLMQTLRERMKIEDLLIAYGMTETSPVTFITAVEDSRGKKATSIGRVLPHSAAKVVDSLGNILPQGSRGELCTSGFALQKGYWKDTEKTKEAMRQDENGVTWMHTGDEGFIDEEGGENISPNEIEDRLLSHPAIVECCVVGLEHKKYGEVVASFLRAAENTAPLSDAEVRLWVTDKLGRIKAPSHVFWIGHADVGSALPKTASGKYQKHLVRARGNALLKRPGIQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEH2</accession>
    <name>A0A1B7YEH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158946.1">
        <property type="nucleotide sequence ID" value="XM_018301096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEH2"/>
    <dbReference type="GeneID" id="28865203"/>
    <dbReference type="KEGG" id="chig:CH63R_06121"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06121"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="90" mass="9866" checksum="88016AEDE3D39C57" modified="2016-11-02" version="1">MVHDLYDKLRAASTLVASCTASSNTLSSRRFSFKYLGVKGDTTARDGAGAEGPTQTHYRSGPRPELSAGEDAYSRPRPEYPKRASRFPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFC9</accession>
    <name>A0A1B7YFC9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159334.1">
        <property type="nucleotide sequence ID" value="XM_018301484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFC9"/>
    <dbReference type="GeneID" id="28865591"/>
    <dbReference type="KEGG" id="chig:CH63R_06509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06509"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601618" description="pectin lyase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="375" mass="38634" checksum="F06D4C6370303C61" modified="2016-11-02" version="1">MFAKSLLLAAAALVQHAAAASAVSGTPEGFASGVTGGGSATAVTPTTNDELVSYLGDSEARVILLTKTFDFTDSEGTATETGCAPWGTASACQVAINKDKWCDNYQADAPTVSVTYNKAGLNPIKVASNKSIVGSGSKGVIVGKGLRIAGAKNVIIQNIKIENINPKYVWGGDAITLDTTDNVWIDHVTTSKIGRQHLVLGTSASGKVTVSNCDFDGESEFSATCDGYHYWTAYFAGSNDQITFKNNYVHHFSGRSPKVNGNSFVHAINNYWAETSGHAFEVDEGGYVLAEGNVFNGISTVLESGGAGATLAITSSNAAQCESKLGRACQANSLTGSGKFDGSDTSVLSKFGSADIPDAVAASSVSSSAAGFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG69</accession>
    <name>A0A1B7YG69_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_06642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159467.1">
        <property type="nucleotide sequence ID" value="XM_018301617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG69"/>
    <dbReference type="GeneID" id="28865724"/>
    <dbReference type="KEGG" id="chig:CH63R_06642"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06642"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="525" mass="58344" checksum="125F57B93BFF6E46" modified="2016-11-02" version="1">MIVRGVSRCSTKLRIPFAKTNATRARPQCRRFAMPSAGTPTASSSGNTAGMLAPFATELDKIAPSFSINGSQIRIIRTPADFYETLKERIRNAKSRIFLSTLYIGKTEKELIATLHEALRNNPNLKLSILTDALRGTREEPNPSCASLLAPLVSEFGADRVEIRMYHTPNLTGVRKKYIPKRINEGWGLQHMKLYGVDDEIILSGANLSSDYFTNRQDRYHLFSSKEVTDYFWNIHNGVSSFSFLVEPSKEPAGFTLTWPKSNPAPSPLKEPKQFIGTTTPTLDALISPKQTTSADTGKDTKVYMLAQLSQLMKPNTSTELPAITHVLSTLGKPEYNGSSWTFTAGYFNPAPSLTKLLLSTASQNNVVITASQQANGFYQSPGVSGLLPGAYTLLARRFVRAVHERKLDDSIVLKEWRKGTVGEPDGWTYHAKGLWITLPGERNPSISVVGSSNYTKRSYTHDLEAGAMILTKDEDLKRRLGEEQTWLQDHAERVTREDFSKNERRVGLQVRIAMWIAQAVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ50</accession>
    <name>A0A1B7YJ50_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160557.1">
        <property type="nucleotide sequence ID" value="XM_018299311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ50"/>
    <dbReference type="GeneID" id="28863418"/>
    <dbReference type="KEGG" id="chig:CH63R_04336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04336"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="59" mass="6755" checksum="550C47C53E6766CE" modified="2016-11-02" version="1">MTPHRDHMIRGRLRQTESGPARATRMLFSRTGQAVERKPRGVFRPHPRGPAGLPRALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJJ2</accession>
    <name>A0A1B7YJJ2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH63R_04539</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160760.1">
        <property type="nucleotide sequence ID" value="XM_018299514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJJ2"/>
    <dbReference type="GeneID" id="28863621"/>
    <dbReference type="KEGG" id="chig:CH63R_04539"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04539"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="542"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="646"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="904" mass="100836" checksum="22A5026D1342CAE7" modified="2016-11-02" version="1">MDVLSASIPVAFREPLAKAELSFPPSPATTVREGLSYSVDGGSEYSVSGGLLDEPSVEGSRTYPLPPKSRTNKVLAEDLKTPDNHVTRDPRLIRLTGIHPFNVEAPLSDLYDEGFITTKDLHYVRNHGPVPKVEDEDMFDWEFTVEGLVENPIKMTLRDLISDYEQITYPVTLVCAGNRRKEQNMVRKSKGFSWGAAGLSTALWTGVSIGDLLARAMPKRGAKYVCFEGADKLPNGYYGTSIKLNWCMDPNRGVTVCYRMNGELLHPDHGKPVRIIIPGQIGGRSVKWLKKIIVTKEPSTNWYHIYDNRVLPTTVSPDASADLPEVWKDERYAIYDLNTNSATCYPAHDEVVPLGGLSETYKVRGYAYGGGGRRITRVEITLDRGKTWLLANVNYPEDTYRLAPEGETLYGGRVDMDWRETSFCWCFWDLDIPIAQLADAADVMVRAMDESMMVQPRDMYWSVLGMMNNPWFRVVIHKEGHSLRFEHPTQPALMAGGWMERVKKAGGNLSNGFWGEKIEGEADNIFEPEEIKDICMTKDTVKRDVTIEELRQHGSEEEPWFVVNGEVYDGTPFLEGHPGGAASIFGAAGQDVSEEFLTIHSENAKKMMPDYHIGTLDEAARKLLAEGEVVPEDDDKTSRSVFLQSKSWTKGILSERKKVSSDSKIFTFTLEHPEQMVGLPVGQHLMMRLRDPVTREAIIRAYTPISEGTDKGKLHVLIKIYYSTTEREGGKMTQALDSIPVGHFVDFKGPVGKFEYLGNGLCSIAGKPQRAVKRFIMICAGSGITPIFQVLRAVMKNAADPTRCLVLDGNRVEEDILCREDLDVMAAAHPDRCRLLYTLTKPDASWTGLKGRMDGKFFEEHVGACPNETGGDELVLVCGPEALEASVRSTLTGLGWKGDDLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLX1</accession>
    <name>A0A1B7YLX1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_05336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161557.1">
        <property type="nucleotide sequence ID" value="XM_018300311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLX1"/>
    <dbReference type="GeneID" id="28864418"/>
    <dbReference type="KEGG" id="chig:CH63R_05336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05336"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="241" mass="27225" checksum="BF5DF7A1824E593B" modified="2016-11-02" version="1">MGLELPQSAKWNEVNINAKLLCIIAMTSGRAFVSPELCRDEIHLDASINFTKNLIIAVYVYWLAARTEPVTLLLEDVQQALTYIEGQFTSTLLQNMKKLDSFIREIKIVIPLSANFYLRKVVKLFQLPNGQTIPEGMFIEVPSIGINEDPEIFPIPDVFDALRFDKLREDKDQLVEVVSQAQSESVGTTHLTFSYGKHACPGRDFTVNEIKMIVANLFCHYDIKSPDGVNGRYQNLALATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM94</accession>
    <name>A0A1B7YM94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative N-acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161680.1">
        <property type="nucleotide sequence ID" value="XM_018296864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM94"/>
    <dbReference type="GeneID" id="28860971"/>
    <dbReference type="KEGG" id="chig:CH63R_01889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01889"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="180" mass="19229" checksum="D9402F53329593EC" modified="2016-11-02" version="1">MSSQPPSSPLRALQASTVFVNTALAGLNLGLSVLVVPRLLESPTPLMLRQWSGMFRRASRLLPLPTVLCALSYWYVAYATAAAARGRVPAAGGDRSRLLAVAGALCFSVLPWTKVFLVEINRKLFAKVKETEGMGLVAVGLTQEEEEGAKYLVDQWGLYNLGRSVATGLGGAVGLYATVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMM5</accession>
    <name>A0A1B7YMM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161824.1">
        <property type="nucleotide sequence ID" value="XM_018297008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMM5"/>
    <dbReference type="GeneID" id="28861115"/>
    <dbReference type="KEGG" id="chig:CH63R_02033"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02033"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="633" mass="70852" checksum="713B7913DDFDE72C" modified="2016-11-02" version="1">MPPDDRPQRQLLPLTAQQPLQELTSTDGDDGNSLGRKRRRPYTSKACNFCRDKKKACDGQPECSQCLRRGLKCEYRVLTDAILKAIPAGFQLVDKEESLSNADAADLLEILKGLPEDEAFEGLQLLRNGNDPALICLALRGNDAGLSSAVLNRATLPPKQSSLEFELMMRHPVAYPTWPPPQPSKADLDFLLLPSEVLWSRSGSTGNADSFSQYLHHQEGESSNSASLVGPRKPSTLYDNRLLSVDITQWTDVPVTNEFSIAVLQLYLETDHPMMPLIDDDLLLDGLLGKNEFCSRILVSGLFAWACVSGLTLTMLHSSCLMCSLIAMQQGYAAFEPEAIIVGHSFYEEAKRLWRSTKEAGVRYGICTVAAVHFLLMTSVTLGAGAQHVEFLDDLLDMSRRLELFNIDPSHDVRLDLDKGATYRKAKSQIAWVLFACLTIYHHLAIMDLFRPLLQHNGAPQQRLSIFQSEESTPDAVYAASVKQLKRIVISYRHNHPESSYSFFWHSALLYLANATLTEVTVTGHTPDWRFYLRLCMACYQTLYTGFRLAKGITLSLLSMALEKGAMDIPQARAIRKDLELRGKHHTIPDEVPVYWVVDLDLAVTDPSAAQVENLVQRFRELQLSETSETFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNE6</accession>
    <name>A0A1B7YNE6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162093.1">
        <property type="nucleotide sequence ID" value="XM_018297277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861384"/>
    <dbReference type="KEGG" id="chig:CH63R_02302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02302"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="201"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1442" mass="159027" checksum="27D69C15DD1F0BBD" modified="2016-11-02" version="1">MASTFPINKQTFVGIVVFLFFLWTMSTFTPTTSTRTIHMTPEQAGEQPGQPDKLRPALDTSLPNESPQLSLASPLSHETAGGNTAHEADKTAAKEAPQTPSPDSTKSKSGGKNKDKDKSKSAPASSKPHAPSSSSSKGHDRPLILYAFAESNAARENLKFFVNQGLHDAADFIFILNGETDISSVIPDKKNIKVISRDNSCFDLGAYGEVLRKDDLYKKYKRFITLNASIRGPFLPHWAQSCWSDMYLGRVTDEVKLVGMTANCWPRFHVQSMIWATDIVGIELLLNPPPRSSIEDQFGTVDDPVGMSGCYDDWNHAVHAEIGSTDAFLKQGYKVDVMMTAFQKSKNYIEECDTSENGDVLWNGRYFGTNVHPYETIFIKANRDIDPTLIEHLTTWHQASGFDSYAAYRFGVSRRARPPEPVATAEFELPIPELEDAPGNLDSSIDHAELLAKRPERNSYTAGSGVRVVVGDIGGVVKDDEGAEADDAGEGDAGKSCQSHSTRSERGQGAASTYKMPMENTIVTMSFLFDGICSWWSSSSCNQAWLNGPALEECRKEKGDRLRQGETNGHPYGKPPTDFSLLKKCTFLDMNGTYDGEDSCFNQWQAGIGGLKGGSIRPTASRSGTSSTSSSWASAARRTCRPYARAWNTALRRLRTSPPLESAFERIWPPKQVSSEAKMKQFAEDEARGHHASCIAPIGADDNPQAVLDSNFKVHGVDGLRVVSASIFPKIPGFYVVLGIYMASKKATDVIFAEAQVAFNRPTGYGLGHARLSIIDLSPAGLQPLHSKDGQLHAAVNGEIYDHDAIRARCAAEHGYDFSGRSDSEVVLALYRHHGAPGFLDHLRGEFAFVLHDERSGDVIAARDRFGIKPLFWTRVNNDDNDDDDDDDDDDDDDGALARILVASEIKAFLPMGWRPEWDVAAIASGAAMQGEGTLFKGVKKVLPGHWMRFARDGSVKQYRYWDANYGDKSVRETRTLEEMTQGVRDRLVEAVRLRLQADVPVGIYLSGGIDSSIVAGITTQLVRERGIKLGSRGAEDQITCFSISFTSDSAYNEYDIAERTAKWLDVAIVEKAMDEAELARHFADSVYHTEHHHYNLNSVGKHALSELPRLRGIPVVLTGEGADEHFAGYPFLVSDLLREPDAAFPSSPIDTDAVFRAAFLETAEAQLRTMFNIVGMFDHPALDDGNPDFWPLAGLDSFWAQLRSHPSNDVFAPWVRRATASDGLDAYAAMVDALPADARQNMLTRWHALHSALYLYLKTSMANMVLTCLGDRSEMAHSIEARLPFLDHELAEYVNGLPPSVKMSYRHPEEGDDNGRATRGQGAESLFWNNMAAARDRLIDKKILRDAGRPFITDEIYHRKKHPYSAPSKWPVGGPMQSMFQDLLTKEAVDQLGFVDYDVVSSSLRSAFGADGDLVAFRKLLVVGAWVVLSQRFGVRPAGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP11</accession>
    <name>A0A1B7YP11_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent protease La domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162318.1">
        <property type="nucleotide sequence ID" value="XM_018297502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP11"/>
    <dbReference type="GeneID" id="28861609"/>
    <dbReference type="KEGG" id="chig:CH63R_02527"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02527"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="386"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="634" mass="71690" checksum="69685CD9EC3D9B60" modified="2016-11-02" version="1">MRSAHFWNLCSSSDPAYMTPGHYSPVPSSLLDHTLTSLEKTTRCRLLHELGARPRIPQRRTYEQIHANLPNTPPRASTEAEGDDFMSSDQPRVVESRPSALTSNPVHEAEDEKDHGNVEHPLSGEQVRDVIRLIQCRKCSRPLRDPITLPCGRSLCRRCLPETHTREHISYPATPNRLRGFECPYQECGRSHAVGDCGVDVILTKAVNNFKAEMEKARDIITTAEISTHVIILRPGAGQMGSEVDDETTSRIVKGGPLVAVYTLAESGELDYSSNVTLAEVSSLGDEAATIDIRTFSKVKETVRTEMDCQVCYALFYDPLTTVCGHTFCRSCLHRVLDHSSYCPICRRGLSVSPLLYRESCPSNEHLKTIIQTFWADAVLTRGDALAAEALNRHREFDIPIFVCTLSFPMMPTFLHVFEPRYRLMIRRALEGDRTFGMVLPQRPRTANDTHFVEYGTLLRIVNAEYFADGRSLIETIGISRFRITRNGILDGYLVGSIERIDDISIAEEEDLEATETQQALERYESAATHMSEDSTTSRPTTPEDLSKMPTSELLSLGVSFVTRMQQQSVPWLAQRMLTIYGECPNDPALFPWWFASILPAKEYEKYKLLETRSVRERLKICCGWILEWESSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ78</accession>
    <name>A0A1B7YQ78_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162629.1">
        <property type="nucleotide sequence ID" value="XM_018297813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ78"/>
    <dbReference type="GeneID" id="28861920"/>
    <dbReference type="KEGG" id="chig:CH63R_02838"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02838"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="1">
        <location>
            <begin position="251"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="343" mass="38299" checksum="613990096173E448" modified="2016-11-02" version="1">MAAARALFKGETQVAIQILKTASVTHPELLFVSLALQLIGRNDSHLSKEQLDFDEAVASKTDPYLRAISSLIATGDWVAIANQKSLPLSDRAYVAVRNFDDEQLTRWLNEQVAMAVETGDIEGIVLTGITDRLVDIFAKYVEKFNDFQTATLVTSICAPRYIDDYRCLAWRNAYRSYLQRHKAFLQRTKFEVESTKKSKRGGRPTIKPPSRQIALRCVYCDAETTLAGQGGAGTGSQAGAPDSRNPLMATSTNAGISCPNCGRHLPRCVVCLEVVGVPRTDRPELNGEPEVWVAANFPTFCLKCEHVLHLDHARQWFTRHVECPVPECRCRCNFRANPELNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQV9</accession>
    <name>A0A1B7YQV9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_03155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162946.1">
        <property type="nucleotide sequence ID" value="XM_018298130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQV9"/>
    <dbReference type="GeneID" id="28862237"/>
    <dbReference type="KEGG" id="chig:CH63R_03155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03155"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601839" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="67"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="404"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="784" mass="85711" checksum="ABDE451BEE7ED0B6" modified="2016-11-02" version="1">MFSFALTAALLLAELASCHRLRGLHSRAHALPHGPSTHADLAKRSSEDLFVRISHDRPILVPTRDDHPQRPVGIKADDAPIQTNKFYANFFAGKQDNATWTYPYSVWWSNDTVKHGHGLSVSHTDRGEFVYGAGDPAQSFEDPLFQQSIALSARELQNGTVLTTDSLTAFAVNVNLAPRKGARPVVTFPLVQGMAFVTGVYSDATVLIQSQKHFSNITDLRLGSYGLGAAVYGWSARLSDGSTWLIYLNPSEYSQRPTLRMTDKGTLLGPRGFTGTVQVAKNPSGPSGVEVFNKAAGAYPAGATISGSVSGKTGTYTLAWTKKGVTQNPLLMFALPHHVKSFDRTTAQGLTSVTLAATTKGIATATFADAFTMVEDNLPTDISFDPWSPRLGSVGSKGAPGGTISDEAKAAVVEAARIELARDVVALTNLTSKYFSGIAFSVYARALYAVHEIAGDTSLTDEALRKLKSAFDRYVNNQEQNPLLYDEVWKGIVSSGSYGNNDSSNDFGNTYYNDHHFHYSYYVYTAAVIAHFDPAWLTKNDGLNKLWVDNLVRDWANPSTEDPFFPFSRAFDWFHGHSWARGVLEAPDGKDQESSSEDAFSTYAIKMWARVTGDARTEARSNLQLAITARSLQSYYLLAADNDVQPPRFVDNRVAGILWDRKVNHTTYFGDVTAYIQGIHMLPIVPTSAYVRTPAFVRQEWDQYFAGNKSGHLTAAGYAGHVYVNLAIADRPGAVESYEFMKGLTPSSPYLDGVSLAWNLAYTAALGGSLNSNSTMNSTIYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR20</accession>
    <name>A0A1B7YR20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GA4 desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162998.1">
        <property type="nucleotide sequence ID" value="XM_018298182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR20"/>
    <dbReference type="GeneID" id="28862289"/>
    <dbReference type="KEGG" id="chig:CH63R_03207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03207"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="282" mass="32287" checksum="20AD41047370EEB2" modified="2016-11-02" version="1">MATCDAITVDIPYVRRDDQGKIPNHAQMFSHDAEFLDLQPAEVRNARATDREFSIPKNGFQYARLTGPPEIDYLDDDQVRNTYFPELEKLVKEHTTLTSLASPGRLGASVVKAFHHVVRNVTYEDGMAYTRKHRCPARRPHVDVTSKFAPILMSWDCPEMHADVHDNGKHWQMVNAWRPLKTVRKNPVTVADTASMAWEDYLTVPQPEVGPGVEGYWLQRPQDAERRHEWWYMADQTPEEVLLFLQHDSGGAQVVGHTSFTQPGPAPKEPRESIEVRLFVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR50</accession>
    <name>A0A1B7YR50_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tnni3 interacting kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163010.1">
        <property type="nucleotide sequence ID" value="XM_018298194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR50"/>
    <dbReference type="GeneID" id="28862301"/>
    <dbReference type="KEGG" id="chig:CH63R_03219"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03219"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="547"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117383" checksum="263D7D4239A3C8F6" modified="2016-11-02" version="1">MANLRDLPPELKIAVAEALAHGNINGYRQADKVVSALAALSATDRFFHKVTDPLLYTFGVMRHPYLLCWATEVGNLDMMKKILQAGSVDPQTGIIRYDPLQEYVPWNPKTESPIERFRRFYRCDGRHFQKPEDYFDALRGGASNPPAPDDGSSPGSNRSDHGAILLFEHSDLDDTSSEEFSENASIADRYSAGEASHDDEDLDGAPAHGNLAADDAEDGHSVNSYDTDEQDEQAEAIAEMIETVKREVAGVIRYYDDFDVEQVDQDDILGLYWFPVHIAATNSDLPALHLLVEHGALLNIPSKGICGECTALYWGDMPSGGLYPAWTPLHLALCRGHTEIAKYILMERPHTKERLVAYDESPWAVLPAFISAIRCEDFQVAEFCLEQGIDDATSIDLVMNNATLLWRAFWETEMFREALEILLRYGAEIDYDLGDGHTLLVEACLHGHFKQAIDLVNAGADTTVVLNSPGPQSALDYAWDRIDRSFPTPIAGCSVLDICCGLSPILSQPGMEAPLPMPPRPRCRPSHKYGSDLIRLLLDTSEGRNAMGCTSLHVAASAHNSKAVKILLDFGMDPSSLDAEGFSALVRTTRCEENYDPELWFCEFPETISVLAEHLRTRRDEGIASCNAANKGTNSSATADGNDALLNIMESRVLAASPRSKLIQHAAALELVATGLADINTRDKHGHTLLMLAVAGGDTEITHSLMKLGASLKRRPAQDDLALLWTTFVLDYEHREPEEVYRLICSVDTEGRIFREPRFLAFAMCELRHKVGELMALSIQPKTLILGDRDASARPGDKQQDPQLVSGLREAETYVDHMASNNERFDGYLRKGWTLLHIAVELGFESVVETLLSQGADANKPTPDGLSPLLVAMKSRAAGSPGMFSLLFNYGADPHANASEATKSPIDFCIREGRFMMFSLLKNYPIRGHPRAHGNLYLHTTVSVQMNGRSCVSEKALLPLIKAGADVNAKDQNGDTPLSFLINEALRLNENLDLDEQKVTDSLPVVPMLIRAGASPSARNNKGKTVMDMMAEVRNHKDGLFGLRDYLRSTLLYDVMLYRNGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR94</accession>
    <name>A0A1B7YR94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163082.1">
        <property type="nucleotide sequence ID" value="XM_018298266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR94"/>
    <dbReference type="GeneID" id="28862373"/>
    <dbReference type="KEGG" id="chig:CH63R_03291"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03291"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="42321" checksum="F912F24B7D7A342B" modified="2016-11-02" version="1">MILSREGFTIDVIARWLRNSVLNPYLSIPFAAGLAVVSARKNGAAGLSDLHLDMAHRVAFLAALASFVLSTTEYLNKWSANNWTTDDTWDFDKEIVVVTGGSSGIGQSIVRHILSRNPRATVVVVDLAPLSWEPPRGSDNVHYFRCDLTDTRALKALCDRIRAEVGDPTVLVNNAGIARGSTVMEGSYADVELTVKTNLVAPFLLTKEFLPHMVRNNHGHIVNVGSMSSVVPPVRIADYSATKAGLTAMHEALQLELKYIHKAPKVRQTLGIFGFIRTPLVPFDPGQPHFMMPLLHVDSVGEAIVNSLYSGLGRTIYLPGIMSPVTVLVSMNGINHSRAGPEWLWRLARETTASAKDITYTPRQKINDATGRLEMAVSAKEEEDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR97</accession>
    <name>A0A1B7YR97_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163096.1">
        <property type="nucleotide sequence ID" value="XM_018298280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR97"/>
    <dbReference type="GeneID" id="28862387"/>
    <dbReference type="KEGG" id="chig:CH63R_03305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03305"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="701" mass="78949" checksum="649D9E17E337895A" modified="2016-11-02" version="1">MSKPRGLRPAPGQLNESASYDPPRETSRRDDPPTIIRIASGKKPEVLPPPPSRKSRIPISVHSPDKQSRTRRPVDGYMRGTVEPPESNFATPAFGTLVHHQPHMYHYSPYYGGADVPGYYTGPHPVGMPSPVTAPVTKDTNNNEEMEKIIRELKARQSDQETIQKTVLDVALRGVTAAVRDMQDKTNLDIEREKVKATMFARDTAEREERKRKEIHDQARQEVETEFALKAAMHENMMQKIREELRQEQERKAVEEMERKAEVREMVQQEAIRLRSLYGFDARASPQPPWEYRSPHVRPYSQHGAPISVMDYLVVDPVLGESRPRPSTSRQHRKHRGHALTLESSEDESEPASLVPDPHEGWQRDVPPFVPSVPLSPGGYSHSWQASHPGRTSAERSFTRSRGRSNEQERPASILLDRMETDGLHLNDTTRKGTDALEDQQNFKEDSEGDEDSDFYTSARASPIQPDDMAEERWNHAKKGQSAKENNRHNIANDWTKEPVFPDDFGGDDKGNIDWPTTPPFGHEGPTISNGPKEEIEQQKLFSLPNHQGILPILSHGHQIDLKTALGDDLRQAQVPQRPGKSMKMFPSNGVAIPASPMIQLSDDYPNTSNDGNQDCQFAEGFRRSTSPVRYPYLPKPSELSLGGQHIGSLQQKQPSTTHVPMVPMVFWAMTPVRFEFRSTTPPVPRSPGQAEGPSPPRPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRH3</accession>
    <name>A0A1B7YRH3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbonyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163148.1">
        <property type="nucleotide sequence ID" value="XM_018298332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRH3"/>
    <dbReference type="GeneID" id="28862439"/>
    <dbReference type="KEGG" id="chig:CH63R_03357"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03357"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="288" mass="30996" checksum="DBB22095A59EB019" modified="2016-11-02" version="1">MTYSRVGVVTGANKGIGYAIVRQLALQYPKSHLNNGSFLIYLTARDKSRGEQAVKNIQGDADLKQAKALSAHGGATEIKYHQLDISDTDSISDLSSFLKKEHPDGVDFVVNNAGIAMQGFDSNVVKNTLACNYYGTLEATRAWIPVLKPDGRIVNVASVSGALSQYSPEIKKRFLDAQSVADVTKLMEEFTAAVEKGTHEKDGWPSAAYAVSKAGEIGMTRAIARELQDKGSKLLVNSCHPGYVVTDMTRGGGTKTPDEGAQTPVHLAIADIGGKTGEYWSDEKVAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS33</accession>
    <name>A0A1B7YS33_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163350.1">
        <property type="nucleotide sequence ID" value="XM_018294988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS33"/>
    <dbReference type="GeneID" id="28859095"/>
    <dbReference type="KEGG" id="chig:CH63R_00013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00013"/>
    <dbReference type="OrthoDB" id="5399183at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="64410" checksum="F001403837EFCAE7" modified="2016-11-02" version="1">MSRNVRNKSSVASRKVAKRRDSITSSSSFDLSDDGGYSAVEDISDSSDDDEEDVDAAEEEHILHEVLPPPSIPSPPRPPIVQEEDDDDDDEDEQEQDEDEEDGAADVEDSASWDGIMSEIDESAASDHHHRSVERHVRFDVPSSDSDSTDTEDDHADFFPDIFVDQSSLDPAFRREIENDDENDESENSNSFWDYHGDYHGAYGNTHDAESDVEAVVQELGDDDTPIATPMTTGEVSEMPTPVAAFEETQELDGYETDGDTTEEDEPEPVVRRKIKRPEPPTEQWDDSDTDIPVKGQRGQPRVGRFNLDNSERKPIAVVNPISRKMMIFTPHRRRQLDLSPEQFNFQYLPPIDENQNSPMLSSSAQIMMSAMFSSNTFGDYLNTQAMGPAEAFFPFPSEPNTADESSDVGFDEEEEDDEVEKSLNISDFIEFDDNHSSGDEEENQWDADPLGSTPARPRTASSDVDLHSHINANNVGAFRRDQINQRLILSDKATQDSLALSSPYNYTALRGLKSDRFETAAVPLTPLRRSKKQMRDLARSPLESMSQKRKASSEIPIGHKRQRSIPDVNMLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSA1</accession>
    <name>A0A1B7YSA1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antigenic cell wall</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163351.1">
        <property type="nucleotide sequence ID" value="XM_018294989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSA1"/>
    <dbReference type="GeneID" id="28859096"/>
    <dbReference type="KEGG" id="chig:CH63R_00014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00014"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="79" mass="8478" checksum="7182D7E21B2C7052" modified="2016-11-02" version="1">MCSCVETALGSIVDAKPKFDRFLLNPIILLNLKQEKSATDNFSAAVIEKLPEALKGAAETLNGGIETAFSMPMLLTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUI4</accession>
    <name>A0A1B7YUI4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_00890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164227.1">
        <property type="nucleotide sequence ID" value="XM_018295865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUI4"/>
    <dbReference type="GeneID" id="28859972"/>
    <dbReference type="KEGG" id="chig:CH63R_00890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00890"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="405"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="877" mass="93775" checksum="59DA9EDA78E4656B" modified="2016-11-02" version="1">MDVEALIEQLTLEEKVSLTAGVNWWHTATIERLGIKPIRLSDGPNGVRGTRFFDSTPSACLPCGTAIGATFDVDLVHRLGQLLADEAHAKGAHVLLGPTINTQRGPLGGRGFESYSEDPVLSGILAGHYVRGVQESGVSATLKHFVCNDLESERMAVNALVTDRAMREIYLLPFMIAIEMGRPRAIMTAYNKVNGVHAAESKAILQDILRGEWGWDGLVMSDWFGTYSTAEAIKAGLDLEMPGPSRWRAGALSHAIMSNKVKVAELDAAVRNVLRLVKHGLENTSIPPNAPETEADTPAHAALLREAAAKSLVLLKNEGGILPFDRAKTVAVIGPNANIATYCGGGSAGLRAYRAVTPLEGVRSLVGGGGGDGNDNSNGKVFFSQGAYGHQSLPLLGKALTTPDGKHKGFVLRIYNDPPPRATERAADGRSALEERVLDDANIWFVDYENAELAPVWWAETEGVLVPERSGEWDFGLSVHGTGELYIDGELVVSNVEDQRLGSSFLGCGTVEEVGSKRLEAGRSYRVLVRFGCSATTKLKASGTVDFGQGGVRFSGCPRLEPAAAIREAVEAARSADQVVVCTGLSGEWESEGFDRTTMALPPGTDDLVAAVLAANPNTAVVVQSGTPVAMPWIDRAGAVLHAWFGGNEAGNGIADVLFGEVNPAGKLPLTMPRRVADNPAALSFRSDNGRVLYSEDVYVGYRWYDTLDVEPLFPFGHGLSYTTFELSDLEVFEAPPAKEANGYTNGHTNGHTNASDTLVVRARVTNTGPRAGAEVVQVYVTPAAPTPLTSSTRDAITRPAKEMKGFARVSLEAGASGTAEVALDVLRATSYWSEMEDCWRSDAGTYGVLVGTSSRGRFLEETVVVEKTRRWKGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVF9</accession>
    <name>A0A1B7YVF9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_01221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164558.1">
        <property type="nucleotide sequence ID" value="XM_018296196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVF9"/>
    <dbReference type="GeneID" id="28860303"/>
    <dbReference type="KEGG" id="chig:CH63R_01221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01221"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="611" mass="67571" checksum="BCC37C49DD503C18" modified="2016-11-02" version="1">MTFLKDPSKKYKAFKPPHLPNRQWPDKVIEKAPRWLSSCLRDGNQSLPDPMSGDEKWRYFKMLCDLGYKEIEVSFPSASQTDFDFTRRLIETPGAVPDDVFLQVLSPCRPDLIRRTVDSVRGAKNAIIHIYLATSECFRQVVFGYTEEQTLELAVECTKLVRSLTKDDPEASETRWQFEFSPECFSDTDPEYALRVCRAVKAAWGPNGKTGDQIILNLPATVELSTPNVYADLVEHFCNNIGDREDHPHNDRGTSIAAAELSQMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVSPEIDFSDLNSVIDMVESCTKIPVHQRAPYGGSLVCAAFSGSHQDAIKKGFQNRQNKGLSSEDPWNGMPYLPLDPQDIGRNYEAIIRVNSQSGKGGTAFILQAKLQLDLPRGLQVAFSKVVQRRTEELGREMLANEITDLFETTYFLRENPHFTLVDYSITPDRSRSPVPAAAGKTQDTKDLIRIFDGVVLAEGKEFKLRGRGNGPISSMVAALKQIGIDLDVHDYKEHAIGEGRGVKAAAYIECKPTGSKQTIWGVGIHEDVVQSSLIALLSAASNFVTSRPNSPILKPAESAPPQETPSLVSVLEEKANGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWB1</accession>
    <name>A0A1B7YWB1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hard surface-induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164837.1">
        <property type="nucleotide sequence ID" value="XM_018296475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWB1"/>
    <dbReference type="GeneID" id="28860582"/>
    <dbReference type="KEGG" id="chig:CH63R_01500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01500"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="480" mass="53990" checksum="94988F4646418346" modified="2016-11-02" version="1">MERFLHFVSNPLQPYSALTHEEDGGDTLGEEEVEKLPPTTRRGALVRGVLWSLLPSFISRPIRRHTDPNFTEEEDDGAIPDPNSTSYLNGLRGIASLIVACQHNTNQYFPANNMGWGDPPGHYHIIQLPFVRTLLSGSFSVTVFFVISGFALSYGPLKKMHQGRADDAIGNIPSSLFRRPLRLFLPVLPVLVFTNLVLIHWFNAFYAMDSESLLPPQTTVWDELCQTWRDIIAVVIGAFPPAAMPQVWTLGAEYQGSLVIFLCCLAFSRVGPATRMSFVTAVFCWQWHVGYWQTGLFLAGMVLADLRLLRPGLPSLRRGTKMVLAAANWFMLFMALWLGGWPIYGEGGSTLGFTYFDWIPTGNVPQNRFWHGVSAIALVSSLENMAGGRLQSWLNARWVLYLGEISYGLYLVHWMIAMNSLTKGTVLQLRLEPGWSDLTAWMVGFAVSMPLCIWVADLHWRLVDKRSVKLARRLSDFFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWJ7</accession>
    <name>A0A1B7YWJ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thermostable alkaline protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164933.1">
        <property type="nucleotide sequence ID" value="XM_018296571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWJ7"/>
    <dbReference type="GeneID" id="28860678"/>
    <dbReference type="KEGG" id="chig:CH63R_01596"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01596"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="556"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="879" mass="102575" checksum="1173AAC4ADB0C5EB" modified="2016-11-02" version="1">MPAVSKPKAVDNTPEHSSLENRTNLSLQDFNRAIREASQIKEADPERAAELILDAMLWDVVKKLPRDDPGVVVAWHHLGECFFLMENYGEAERFYRQVFQARRSQKSPNSSMILRARQDLTASLIEIAKEEETRDVARSEKLYFEALGFAVESMNEEANDKRGEDIDDVLHCTKALLKNQDRKPLELAELNRTRFQAFVQIDDDMEDEELLDMQYHGIVATKHFTVELEDRKSGYEVYDTLQSRIREYGAEDPDQSETAVCIGEEVEDEWRKATGLLARKRWRRCLEQVRAEVRRDVLPRKKQIRDKWHLICRRLMAKQKWQRVLSEARKTARWNITCRRRLVMDQWNSLVQEALQRKRDEEENRKKEELKKLEEEEKKRKIEEDQKRKRDEEQKALEQEEERRKREIEEKRMAEEEERRRYEEKVRLEEEEEKRRDEENRLKRLDEEREQKMREKEFEDRQREEEEHAKQSAREAEEEEAMKREINMLQDLEIQQGISRTDTGYSEWSEPDTEPAFFDSESILSSIQNSEKWMKDFIRSRNTILSPQHDKNMERVRVTIIDTGLDRTHPFVIKRRWQDSRQAANKKVALFQDFVTENPSTEAIDEDGHGTFIAGIVLQLAPLVELSIARVATTRASLMKDPDAEGKVTKAIIHAITEWDTDIISMSFGFRTYKTQEFRAAIGRANWENKILFAAAGNFGNSKANVSFPARFPGVFKIFATDHQGGKCSFSPSPDLEKSYCFSILGHDVVSIWPEAMRDKDGETPLKVVDKKKSPGLWVAMSGTSFATPIAASVVAILYQFYDANKAEINLEPGLDFKTVDAVRAILLKMSMAPTADQHNYLNPWVGRDNYFNFSGEEKNGSVSFFAQMLRLCLGAWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1UV44</accession>
    <name>H1UV44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_16148</name>
        <name evidence="5" type="ORF">CH63R_07682</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000186">
        <property type="protein sequence ID" value="CCF31845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157435.1">
        <property type="nucleotide sequence ID" value="XM_018302657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UV44"/>
    <dbReference type="STRING" id="759273.H1UV44"/>
    <dbReference type="GeneID" id="28866764"/>
    <dbReference type="KEGG" id="chig:CH63R_07682"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07682"/>
    <dbReference type="eggNOG" id="ENOG502S1BF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087364_0_0_1"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF31845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="188" mass="20656" checksum="E3EDF1490DFFCCE6" modified="2012-03-21" version="1">MATAQAQTYAPTKVVKSDYPLIDNDPHFKRVIGYARPSDYLHGAVAAAFGPAALLTLEKFAPSHVGKGGMAQAMRLAGAVGLAGGFLYFYQRSSLRFYGATENAREVEMDMKEMVAKVKAGEPLYGASRLTPHMQGVAARQSRYSALFMGVVPWFNFVNHNQHGVDTAKYYQQAERELEAERLQNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVR6</accession>
    <name>H1UVR6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf1014 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_04525</name>
        <name evidence="7" type="ORF">CH63R_04724</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000311">
        <property type="protein sequence ID" value="CCF32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160945.1">
        <property type="nucleotide sequence ID" value="XM_018299699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVR6"/>
    <dbReference type="STRING" id="759273.H1UVR6"/>
    <dbReference type="GeneID" id="28863806"/>
    <dbReference type="KEGG" id="chig:CH63R_04724"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04724"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069723_1_1_1"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="5">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="24275" checksum="8CA9A4514306B0B9" modified="2012-03-21" version="1">MAGKKGADNTKKVAGNARKAEAAAQKAAAEDAKKAAAEDAEWSKGAKGNAKKEAEAAKKAEAARKKAEKEALLKEEEASTPGRAGPKNNKTAVKKTRGLDLSQLDDDRSGGPLTSLNATGIDNALDALSLTASDPNAKIDRHPERRFKAAYAAFEERRLKEMDDDGTGQGLRLQQRKDKIRKEFEKSPENPFNQVNAKFDTTREELAEMKQKEKSKIEARLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXB2</accession>
    <name>H1UXB2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Large neutral amino acids transporter small subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00835</name>
        <name evidence="7" type="ORF">CH63R_04179</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000480">
        <property type="protein sequence ID" value="CCF32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160400.1">
        <property type="nucleotide sequence ID" value="XM_018299154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXB2"/>
    <dbReference type="STRING" id="759273.H1UXB2"/>
    <dbReference type="GeneID" id="28863261"/>
    <dbReference type="KEGG" id="chig:CH63R_04179"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04179"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_3_6_1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="527" mass="56816" checksum="E5AD53590BB0AA60" modified="2012-03-21" version="1">MADVPRADETSPFLQRPPVARSASYDSDGHPVAARKLTLFNGLAIVISLQIGSGIFSVPSQISQFVTAPGYGLLAWLFGGLLVWTGAASFIELGLRIPNNGGIQEYLRACYGEFAGFLFTWVWCIIIKPAANSMIATIFADYLTEAFVADQEALSPWISKVVAAGCIVTMTLVNCMGATAGAKAANLFLFLKVAALAAIVVLGCGVWAFGHGEGVPSSEYGWFGQAPEQREIGLWEWLGDFGTATFGALWCYAGWEMVGFVLGDMKDPRRDLPIVINGSMIVVIIGFMLMNAALYVCLPMSVMRTSSTVAVEFANRILGNWAGLVFCLVVSVSAMGALNSNVFATAKLVIVASQRGYFPAILANLHCSHEKDEAACVDEYMASLPRLAKVPIKGFLSWTRNRRWRRNVPLLPLLLNCVLSVVYVVVGSFNGLVTFIGLAAYTIFFSSAIGLIVLRRRDARNPPANAAEYSTWLINPIIFSAISGLLVVRGVISEPVQGGAILLVAIFGVVFFSLRFGLRGFTHTEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXV4</accession>
    <name>H1UXV4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoflavone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05120</name>
        <name evidence="3" type="ORF">CH63R_05276</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000543">
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        <location>
            <begin position="2"/>
            <end position="241"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Shea T."/>
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                <person name="Sykes S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
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    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="139" mass="15444" checksum="9A198FC4FC25E489" modified="2012-03-21" version="1">MSSQVIAAARQVVRELHGVVVSAGLMQKTVKVRVGGQQWKQAVQKMFTRPKDYLVHDPNSSLRTGDVVSIVPGWRTSPLKRHVVKSIIAPHGIPISERPPIPSEEERISAKIQKREAKVARRTTRKQEGSSLTEVPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0E3</accession>
    <name>H1V0E3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05832</name>
        <name evidence="10" type="ORF">CH63R_05418</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02000858">
        <property type="protein sequence ID" value="CCF33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158243.1">
        <property type="nucleotide sequence ID" value="XM_018300393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0E3"/>
    <dbReference type="STRING" id="759273.H1V0E3"/>
    <dbReference type="GeneID" id="28864500"/>
    <dbReference type="KEGG" id="chig:CH63R_05418"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05418"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR09726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25538" checksum="4207291D6B0BD6B0" modified="2012-03-21" version="1">MPQDRFRPALIVVDFQEDFCPPHGSLAVANGRDIHPVVNSMLRLPFATKIATKDWHPPDHVSFASNHEGKQPFVDTVDIVNPRNGAETFRTRMWPVHCVQGTPGAALVPELDASAVDTVLEKGQNSNVEMYSAFYDPFQSPRVSDTGLAETLRDKGITDVYVVGLAGDYCVKWTALDANKEGFRTFIVEEGTRPVDAERWDECKGELEASGVRIVSVEGPEVRRVVTAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0N2</accession>
    <name>H1V0N2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05906</name>
        <name evidence="5" type="ORF">CH63R_03189</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000894">
        <property type="protein sequence ID" value="CCF33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1V0N2"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03189"/>
    <dbReference type="eggNOG" id="ENOG502QU12">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
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    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="371"/>
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    <feature type="domain" description="DUF7605" evidence="3">
        <location>
            <begin position="694"/>
            <end position="862"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="490"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="937" mass="105154" checksum="F8576C17EADAFB74" modified="2012-03-21" version="1">MDCDADTLRVAKIEPKDEAQSPHPQHERPSSVSLQEPKSEPDEKIMPASSDDEDSASTSPPPHKAFSYRNKMKNMKDPETWETFTQQVLPLLDELEPECRKMASSRKLQPAVRKAACHWLQQIRDLRERAERSNQTIVGVLGNTGDGKSSTINALLDEENLLPTNCMRACTAVATELSYNHEDDEENPYRAEVEFISRDEWSREVSVLLRDLVADEDMKMDDMDPNSDAARALAKILAVYPSLDTRTLTESSSAQLVEHPNVRELLGTTKTVKAPSASEIREQVEPYVDSNDKDDDTAAYWPLVKVVRIFTKARVLSNGVTIVDLPGHQDWDAARAAVASQYMKACSGIWIVAPINRAVDNKTAKDLMSNSIRRQLKLDGAYSALTIICSKTDDITINSAMESLKGKLCKETMQAWKDALACERRIKALEKELLALRKRRSATQALGSAGSRKRRAKRARTEAPSKSRATAVSHEPADEDAGTEASASKFDEKEQELYDWKLEKKELMDQVHAQCIQRRNELSREAVKRHLAKSFRDLDRQDAAGYEAQTDGEPRDYEDMSRQTPVFCTSSHVYQQMRGLLMTDNDLTPGFETEDDTEIPQLQDHAQKLTEELRVAKQKEVLSGICQILNSVAIWAQDASKSTVTIDSATLTTSLQMFEANLKADGQSCIDRLDMEAQTKLYDGLTRLTSTATTQAGIIANKWQSINGGTFKAICRRGGVFKHHDFNEQLLEPILNGISATWDKFFQFNIASVLDGFSVAATGRLTAFHEGIVEQLGDHDFGELQASVQLDQQLKLHKERILRLAAQSRADIDQAQKDASRAFSPAVEEVMMPGYQRCAVEKGKGMVKRMRAMIQEHIRKNKVQMFRSAVKNVRHSLEQGTKLVDDNMTEQIKTIAATMTDDYMLALAERQKSAHLHEAKFKKEVMEVLETAANHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V592</accession>
    <name>H1V592_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_07192</name>
        <name evidence="12" type="ORF">CH63R_12903</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001520">
        <property type="protein sequence ID" value="CCF35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152294.1">
        <property type="nucleotide sequence ID" value="XM_018307877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V592"/>
    <dbReference type="STRING" id="759273.H1V592"/>
    <dbReference type="GeneID" id="28871984"/>
    <dbReference type="KEGG" id="chig:CH63R_12903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12903"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067602_0_1_1"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF35394.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR03776.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="317" mass="35237" checksum="96F0F61175BCD1DD" modified="2012-03-21" version="1">MSVRQTRRQAAQAAAGESPKVANEEPVQQAVMNGNENEVAATGASEDVPKENIFLFLPNLIGYFRIVLAIASLYYMPLHPRTCSLLYSVSCLLDALDGYAARAFEQSTRFGAVLDMVTDRCTTSCLLVFLSCAFPRWTIVFQMLLSLDFSSHYIHMYTTLSMAGSDSSHKNVDESRNRYLYLYYTNKTVLFVFCALNELFFIALYMLSFSSPRFSPALLSSVSNSEAMQIQAGAQVNTSLLSHIFPNPYSAAALELARANKMDSTLPWVLASISFPVMFMKQVINVMQLVNASQWLAEGDVAARRAKGLPKKKTKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6H2</accession>
    <name>H1V6H2_COLHI</name>
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        <submittedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_07527</name>
        <name evidence="5" type="ORF">CH63R_09937</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001711">
        <property type="protein sequence ID" value="CCF35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154335.1">
        <property type="nucleotide sequence ID" value="XM_018304911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6H2"/>
    <dbReference type="STRING" id="759273.H1V6H2"/>
    <dbReference type="GeneID" id="28869018"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09937"/>
    <dbReference type="eggNOG" id="ENOG502S7DD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033916_1_1_1"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="93"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="461" mass="49415" checksum="A21D35D3B663D1E9" modified="2012-03-21" version="1">MAEEEFEIDIYGDAPQDQQDGNAENYDGQQANGHADDHHEHQEHHEQREDQQKHDHQTQQQDEYNEQQDAPAPQQGVKRKGDDRPVDPGATTALMISDLNWWNTDDDIRGYARAAHCEDEMKDITFSEHKVNGKSKGQAYVEFTTQQAATAAKHALEATDGGQGVPKKHQVTYSNPHVNPFRTLPKDAPNRAGKEQGSRPGSNYNSQGPPMGGGEFRGNGYRGRGGFNGPRGGMNQGGFNRNFSGGMGGGFNNNNNMGGGFNNGMGGGNFGGGGFQRGGGFGGGMRGGPGMRGGRGGMHNPMGGMGMGPMGGMPMGGMPNMGMMGGGMPGTTPPSLGLSQHCHNPSTPSTANGTSQRGKQSGRRKGKAAKPDQAQPPSHPKRQKVQHQPVSTQSQLVPAPEVGRWTKERGLEFTTRAPSLPDLPSSDFRMPPCSARHSGNPPELFPSCLQFIRPVRRGHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6S6</accession>
    <name>H1V6S6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_01401</name>
        <name evidence="2" type="ORF">CH63R_11222</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="6">Small nucleolar ribonucleoprotein complex subunit utp14</fullName>
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        <name evidence="5" type="ORF">CH063_00230</name>
        <name evidence="6" type="ORF">CH63R_08109</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02002013">
        <property type="protein sequence ID" value="CCF36511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157861.1">
        <property type="nucleotide sequence ID" value="XM_018303083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8F8"/>
    <dbReference type="STRING" id="759273.H1V8F8"/>
    <dbReference type="GeneID" id="28867190"/>
    <dbReference type="KEGG" id="chig:CH63R_08109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08109"/>
    <dbReference type="eggNOG" id="KOG2172">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="277439at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
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    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
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            <end position="70"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VA30</accession>
    <name>H1VA30_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08503</name>
        <name evidence="11" type="ORF">CH63R_01430</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CACQ02002296">
        <property type="protein sequence ID" value="CCF37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164767.1">
        <property type="nucleotide sequence ID" value="XM_018296405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA30"/>
    <dbReference type="STRING" id="759273.H1VA30"/>
    <dbReference type="GeneID" id="28860512"/>
    <dbReference type="KEGG" id="chig:CH63R_01430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01430"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_0_1_1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF37083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR16250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="188" mass="21071" checksum="BD6681A52285BF2E" modified="2012-03-21" version="1">MSPDSRPKQHIVFLTGPTGTGKTTIAKHLTESLHMTFIEGDDYHPKENVEKMHRGEALTDDDRWGWLDALRDESLRELDRDGEGGGDGVVVTCSALKRAYRDVLRGASHPERDIFVHFVTLHAPEPVLLDRVRHRHGHFAGANLVHSQFQSLDPPQADEPDVVAVDVRPPVEEVKRDALAKLKELLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCR1</accession>
    <name>H1VCR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01814</name>
        <name evidence="3" type="ORF">CH63R_11679</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002757">
        <property type="protein sequence ID" value="CCF38014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCR1"/>
    <dbReference type="STRING" id="759273.H1VCR1"/>
    <dbReference type="GeneID" id="28870760"/>
    <dbReference type="KEGG" id="chig:CH63R_11679"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11679"/>
    <dbReference type="eggNOG" id="ENOG502SDRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008005_0_0_1"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    </feature>
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            <begin position="723"/>
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        </location>
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            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
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            <begin position="112"/>
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    </feature>
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            <begin position="689"/>
            <end position="708"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38014.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR04976.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="865" mass="94339" checksum="C9E880116C68AACC" modified="2012-03-21" version="1">MATQTVHAHAGHAHSSSTSSYPPRPASPTLTNPDMILPDYDRSPSPDRSHSPLTMWKNAHTVDMNMQFQFPPSAYVAGPITPTTPIIYGNGTMLSDIGEVTEAESTPGRASRPTSIIWSRPNNRGADEPRYPSPTKALESLKQRAARATRERRSSNDSTSTITTTQDQNALFAEFDDTVSVDDSNFQGDDEESVAESYAEDVSVHQAQAISQPIRVSPLDDPNRYSTALISRRAEQILANAKRRLTTMEGNLSRARSSLSISTPSMSSFEGNHSTPSPPIRSSSSATSPTSGHGHGRMLSDTSINFDANAAGNVPRRSASAMGAAGGYRQPLSVRKVSHDAAIDRLDSGGEGQPRYKAAQEIGLEPLGEDEVAQEFHSGSDSTRQESLLSPTFSSSSRDRPLTRSASVAQMRDIRGQVQDLKGKISSLREQARADSMRRRSMQSLRNPSPFTHAQVDQWYAEPRKQQSPEALTVTSDKNPWNADAVSVDGLVQEREDVDGAREPSLVDDESIIEDYDAAQEAIRQEERQKALDAMEANQELDDVAVQDDDISDMHTEDGFEDSVQVQEGEGYESESGDSLYHDTVQTFMSHEDREDAFDYEHFFLHSAMGSLTQQRRGSVTSESSVETTRGPITNETIRPISINRRGSGDTTSTIESFATAYEGRSSRVSTSDTGEELRHGILTPPSISPISEHTESPSTAKRSTIGSTLGGEDVLDELRSRARAGSTAYRRPMSTQATMGHRHATASFDSTGTNRSFPLVGKARVSVGVPTPQGSPELELKTISDALMSETASICDKESMHTPNQLAPMEQLAKEDQILVERFVASLGRCVLAMSEAGKASAESRMYRRRIDMARRVLEGIGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VF45</accession>
    <name>H1VF45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_09836</name>
        <name evidence="5" type="ORF">CH63R_13622</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003186">
        <property type="protein sequence ID" value="CCF38848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150914.1">
        <property type="nucleotide sequence ID" value="XM_018308596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VF45"/>
    <dbReference type="STRING" id="759273.H1VF45"/>
    <dbReference type="GeneID" id="28872703"/>
    <dbReference type="KEGG" id="chig:CH63R_13622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13622"/>
    <dbReference type="eggNOG" id="ENOG502STIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027165_0_0_1"/>
    <dbReference type="OrthoDB" id="5386093at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555229" evidence="3">
        <location>
            <begin position="26"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="451" mass="46285" checksum="C61FD29421B057ED" modified="2012-03-21" version="1">MLFSRRLSPTSAILLLSNVLNFAEAGAFPRQTQEHIALRTLDVRNWPLATPAPWLGMMRRQDDSSTNTVCGYLGGDPNLPATCSAGSHCAMDASASAVGCCPNGAACTTGVYTSCVDNNSPTQTVSNPYIFTCQGDNVCYRNAYEGGAYQYGCGTASQGTSVFATASGLSTTVAITRISGLVTIEATSSSTSSSSSSSSSSTSSSTSSTTSSTSSTTRSRSSTSTTRSATTTQSQPPTSSAAAPPPGAAEAALRRHGGVIGGAIAGAAIFVAIVSVALWMLKRKRGNRRRGPGLGKGTSYIPQTNPKDFTPVPGGEVMFDQAGYGHPAMMPGAHGTTTSISGGRSANSPPSSTPGGYNPASGASASGASRSICEDMPLTHQSEMEEFSRGYNDAVTPAGHDDHRAVSSGGNSSANPYGAGAGASSGQQSDVADERPLWQQNRRQSRNLMWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJP8</accession>
    <name>H1VJP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid 7-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11013</name>
        <name evidence="3" type="ORF">CH63R_10180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10180"/>
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            <end position="141"/>
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    <evidence type="ECO:0000259" key="1">
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
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        <property type="protein sequence ID" value="CCF40524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03045"/>
    <dbReference type="eggNOG" id="KOG0362">
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        <property type="evidence" value="ECO:0007669"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="547" mass="59430" checksum="2D44A31FDCD639A5" modified="2012-03-21" version="1">MSLNIPNAPNANLFKQGYNNYDSEDGAVLRNIDACRAISSTVQTSLGPYGRNKIVINHLQKMILTSDAATILRELDVVHPAAKLLVMASQQQESEMGDATNMVIVLAGELLKKAEDLLRMGLKTSDIVTGYERAQKFALETLDELSVDKVEDIRSQEELSKAIRTVVASKQNGSEDFLADLVAEAVLAVLPKNPVGFNVDNIRVVKIMGGALEQSRVVKGMVFPKEPDGSIKKAQHAKVGVFSCPIDTSQTETKGTVLLHNAKEMMDFTKGEESHLEAAIKELYDVGIRVVVAGSTVGELALHYLNRFGILVIKILSKFELRRICRVVGATPLARLGAPMPDEMGSIDVVETLEIGGDRVTVFRQEDEATRTATLVLRGATQNHLDDVERAVDDGVNVVKAITRDPRLVPGAGATEIQLVERLNALGEKTPGLSQYAIRKYGEAFEVIPRTIAESAGLDATEVLSRLYMAHHKKDDWATGVDIENDDGSGTLDAREEGILDLLVSKSWAIKLATEAARTVLSVDQIIVARRAGGPKPPGPNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKY4</accession>
    <name>H1VKY4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11332</name>
        <name evidence="4" type="ORF">CH63R_09302</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004364">
        <property type="protein sequence ID" value="CCF40887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156299.1">
        <property type="nucleotide sequence ID" value="XM_018304276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKY4"/>
    <dbReference type="STRING" id="759273.H1VKY4"/>
    <dbReference type="GeneID" id="28868383"/>
    <dbReference type="KEGG" id="chig:CH63R_09302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09302"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_0_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="98"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF40887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="519" mass="60186" checksum="8C1A39A5CE209F84" modified="2012-03-21" version="1">MNGHAASKVSMSHEEGMGLLDEKTLSDVESESGRVDLEARFAIPPWSTVARGAVGYVRAVPWRITAIRGLIFLLPSFVQNRFTRERCRSEKLFPTSHLDGMRGLAALFVFFCHYFYQAFIIAEGWGSSEKNYHVLKMPFLRLFYQGPPAVCLFFVISGYALSMKPIKLVRAGNFEDFSATTTSLIFRRFIRLYLPTAISTFGIMMLLQLGVYEWTRDFATDRTYHKNVMEPHPKPLDTFSEQLTDWMWSMFNFVHVFGWEKFGGSTSYDVHLWTIPVEFRCSMYLFVTLIGLARVRTRLRFLFLWAIIAFTYRNNRWELLLFYFGMMLAEYDQIMGNNTPVGGSVLPANEAQPIRNRFKGFCWAMLSILSIYFMCQPDINYEITPGWVWLCSFIPKWWDAEGYRFWQSIGAVIFVLCVGHSPRWKSFFNLAPIQYLGKISYALYLMHGPVMHTVGYVIERRAYAITGVEGWWYNAGFVLGSMGCIPAVIWAADVFWRLFDIPTVRFAKWVETKCSIKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VM17</accession>
    <name>H1VM17_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_11600</name>
        <name evidence="9" type="ORF">CH63R_11960</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02004594">
        <property type="protein sequence ID" value="CCF41270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153775.1">
        <property type="nucleotide sequence ID" value="XM_018306934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VM17"/>
    <dbReference type="GeneID" id="28871041"/>
    <dbReference type="KEGG" id="chig:CH63R_11960"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11960"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF41270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="56898" checksum="45F6ECBB2079FF6D" modified="2012-03-21" version="1">MDAAQLNDQMKITQGLDNKGVDVDNVENQVPADPNAPRVMSPERRVAVEKSLKRKIDTRCSLFVLIYIMNYLDRNNIAAARLRGLQTDLNLDDTQYATCLSILYVGYILMQVPSNMIINKISRPSWYIAAAMLVWGLISTLSGVTTNFGGMVATRFFLGFVEAAFLPGALLILSKWYTRRELSTRNAILFCGNLISNAFSALIGAGVLSNMQGVLGHAAWRWLFWIEGAITMAVAISAAFILPDLPTNSKGFTEEELYVAQLRMTEDVGEADVDSDDMGPMDGLYMAVKDVKIYVMMITFTAYVVGLSFNAFFPTLTGTLGFSYVPTLLMSSPPWAFSCIVSLINAWHADRQQERFWHIVGPICVGLVGFVISMSTLNVAARYVALFLQASSYAGFIVFYSWISSSFPRPPAKRAVAIAMINAFSQLGNIAGSYVWGLKDNGFRKSYGIVTAMFGATIVGCYVFKVILDNLNKKLEEGERAWEVHGDVAHQTADITHGDEIEAARQMGKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VM44</accession>
    <name>H1VM44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02556</name>
        <name evidence="3" type="ORF">CH63R_03509</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004612">
        <property type="protein sequence ID" value="CCF41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163300.1">
        <property type="nucleotide sequence ID" value="XM_018298484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VM44"/>
    <dbReference type="GeneID" id="28862591"/>
    <dbReference type="KEGG" id="chig:CH63R_03509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03509"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="311" mass="35524" checksum="D78DB209040DFB73" modified="2012-03-21" version="1">MGKKRVLVSYGVDVDAVAGWLGSYGGEDSSNDISRGYFAGTIGVQRVLKLLAKYNIKATWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPTDMTIEQQRDILDKTYRMLTDFVGKPPRGSVAPWWETSREGAQLLLEYGIEYDHSMSHHDCQPYYLRIGDEWTKIDYTKKASEWMKPLVRGQETGLVEICSNWHLDDLPPLMFIKDAPNSHGFVNARDVEDTWRDHFDYFYREYDEFIFPLTIHPDVSGRPHALLMHERLIEHMMKHEGVEFVTMEQICDDFKAKNAPAEGAIMPAEPGAILKNATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPM4</accession>
    <name>H1VPM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_12251</name>
        <name evidence="2" type="ORF">CH63R_09830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005206">
        <property type="protein sequence ID" value="CCF42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154228.1">
        <property type="nucleotide sequence ID" value="XM_018304804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPM4"/>
    <dbReference type="GeneID" id="28868911"/>
    <dbReference type="KEGG" id="chig:CH63R_09830"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09830"/>
    <dbReference type="eggNOG" id="ENOG502SQW6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081916_0_0_1"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="268" mass="29299" checksum="7134A4B042506BFC" modified="2012-03-21" version="1">MARGEASGNLLLGHVIPSLKALDQVINSDGPLPFPKDMRIEQSTMYDIQWSTSKESGIEASAKADVPVAAAAGLSVRGDVALEFQRGVGDSWQFDQVDTQTIRPTKNYIRQCLKTPLVAAHIERVKFLNKWKLLMVSGIMIAKGARTERSESKGRLAHFKPGMNMAEVVSAEIGAGVSRTTQSSLSAQHENDFIWAVRLTELSKSPFRSDVSERVLTKGATLGLDDDLPDIDSIADAAGVLDYHQIEHETADEGQRIYFILSTDENAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPW4</accession>
    <name>H1VPW4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pfs domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_02789</name>
        <name evidence="10" type="ORF">CH63R_12379</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005268">
        <property type="protein sequence ID" value="CCF42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151770.1">
        <property type="nucleotide sequence ID" value="XM_018307353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPW4"/>
    <dbReference type="GeneID" id="28871460"/>
    <dbReference type="KEGG" id="chig:CH63R_12379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12379"/>
    <dbReference type="eggNOG" id="KOG4266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014424_0_0_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
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            <begin position="698"/>
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            <dbReference type="ARBA" id="ARBA00011073"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQU1</accession>
    <name>H1VQU1_COLHI</name>
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        <name evidence="3" type="ORF">CH63R_04434</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018299409.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759273.H1VQU1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04434"/>
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    <dbReference type="OrthoDB" id="4579481at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="311" mass="33810" checksum="FC29039DA268EDE7" modified="2012-03-21" version="1">MGKKTYEADSDSDMEDGGAKLNAPTNAVVRSTDAMDLDVPPTPAEKKQAAAIARAERALRRKQRREELAAPGASQISSMASTPNPDSQPASPTTNGQDRRSRRKKTERKSPVKTDKIEEVVGDKAEEKVEDEIKKTAEEKAEQTPAAEVEISGEPAIAPAPASAVDAEPLPFVIEVTRSKVEPANASVAGDSTSNAPSSVSGVDPQHQGLNRAARRRLMQIENRRLAIKKELGLASDSDERRAEVDSLLATWTAQFDERIEARAAKKAAKKAESIAKGKLLTGRNANDYEKQKQIKKQKQKEALRARQQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="HOGENOM" id="CLU_005533_1_4_1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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            <begin position="218"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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        <source>
            <dbReference type="Pfam" id="PF00891"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03129.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="446" mass="50059" checksum="2AE47909B5A0BE46" modified="2012-03-21" version="1">MSEARVLKDIPLGPKLCDQDLEDLGRQCLKLAAQLKGQLSELNHPLPTFFTQSFDRYPARNQAVNTTRHQLREAAQTLYELACGPDEIVTRELYAKIHDINAFTYVSRYNVAEHIPVDGSISYTILAAKSGTGIVQLRKALRHLMTLRVFHESEPEHVTHSAASKTLLDSGVKLYNSFLCNETSKLAVFQTDAIEKWGHDCVEPDQTAHNIAHRTNKPIFQYLSENPARAADFGQLMRYLFKTAAIDSEMLLQSYNWSALGAATVVDVGGSTGHCSVFIAKTNPALSFIVQDLQHVIADASDPAKCVVPAEMSNRIVFQVHDMMDPQPVIADVYFLRMVLHDWPDAVCRKALRHLATAMSKRPGSRLLIVDTVLPPAGQWSRVFERPLRVADLQMGLFHNSKERQLSEWEDLFHHSHPGFLLRSVLNPLKGPFSILELVLREGFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRK2</accession>
    <name>H1VRK2_COLHI</name>
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        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
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    <gene>
        <name evidence="8" type="ORF">CH063_12732</name>
        <name evidence="9" type="ORF">CH63R_11739</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005692">
        <property type="protein sequence ID" value="CCF42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153554.1">
        <property type="nucleotide sequence ID" value="XM_018306713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRK2"/>
    <dbReference type="STRING" id="759273.H1VRK2"/>
    <dbReference type="GeneID" id="28870820"/>
    <dbReference type="KEGG" id="chig:CH63R_11739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11739"/>
    <dbReference type="eggNOG" id="KOG0870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043417_1_0_1"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="36844" checksum="BB1DE395A6F7542B" modified="2012-03-21" version="1">MPPRKSDASRRSDVSNARFIVMDEDPAPAATPATAASTSSNGAAGTPSAAPRTKASVSVSASATPSSVPPAAAASTPDSATGVRPTSSTPLTTTTVLHAGSEKKESQTHDKMAKADRDALTIEDLSLPKSIITRLAKGVLPPNTQIQANAVLAMSKSATVFINYLASHANEITVNANKKTVSAEDVFKALDDIEFGFLREPLEQEFAKYNQIQSAKRTSYRQKVAAKKGGSAAAGVAVGAAAGAAAADASLLSNADDSAMTTASSDTAPRAKKARVDDSAMTVGEDVDDGETEPEEEAEEEEDNDNEEEEADEEEDDEEDDDEEGEGSGDETQDALEEKGEGSDVDEALDGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VT37</accession>
    <name>H1VT37_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03063</name>
        <name evidence="4" type="ORF">CH63R_03691</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006068">
        <property type="protein sequence ID" value="CCF43395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159912.1">
        <property type="nucleotide sequence ID" value="XM_018298666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VT37"/>
    <dbReference type="STRING" id="759273.H1VT37"/>
    <dbReference type="GeneID" id="28862773"/>
    <dbReference type="KEGG" id="chig:CH63R_03691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03691"/>
    <dbReference type="eggNOG" id="ENOG502R99E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090704_0_0_1"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497747" evidence="2">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="244" mass="25513" checksum="079DA4E77932C55B" modified="2012-03-21" version="1">MHAPSFTFGLLGQAVLIAAVPLKPRPVTIESRDSLDDIEIALVPVFDSLQRVDAAVLALDGTPNAAANLLGASQQIQVTINQATLTVRASRDLSAAKSLMLRRTTDNLAAQTKTTVNDLVARKPILDQLGVSTVALQSLQKQQMASMSLSEALAAKVPKVGQKEAAADMATLQSIFTQAIAAYSVPAAVPAPGAAVPPPIAPVPAPPAMMAPPAGRKDRKKKKKEAKANRHDVDVLAEGHMTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VU82</accession>
    <name>H1VU82_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GMF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03158</name>
        <name evidence="4" type="ORF">CH63R_13983</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006379">
        <property type="protein sequence ID" value="CCF43790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151275.1">
        <property type="nucleotide sequence ID" value="XM_018308957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VU82"/>
    <dbReference type="STRING" id="759273.H1VU82"/>
    <dbReference type="GeneID" id="28873064"/>
    <dbReference type="KEGG" id="chig:CH63R_13983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13983"/>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087056_0_0_1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="168" mass="19296" checksum="260771F8E9EEF2CC" modified="2012-03-21" version="1">MVRPRFFVLPSAAPSPIRPNHHGLTFQASESRLYTFSQETKDHLRKFRLGTSRSNEPQAVIYYIDKNTHEIRQDDDKVVYKSLDEISDDLPDHSPRFVLLSYPLTLPSGRLSVPYVLIYYLPITCNNEIRMLYAGAKELMRNTSEVGRVIDIQDAEDLEEIPQKLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVL0</accession>
    <name>H1VVL0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrodipicolinate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_13724</name>
        <name evidence="5" type="ORF">CH63R_04290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006763">
        <property type="protein sequence ID" value="CCF44270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160511.1">
        <property type="nucleotide sequence ID" value="XM_018299265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVL0"/>
    <dbReference type="STRING" id="759273.H1VVL0"/>
    <dbReference type="GeneID" id="28863372"/>
    <dbReference type="KEGG" id="chig:CH63R_04290"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04290"/>
    <dbReference type="eggNOG" id="ENOG502QWNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_0_2_1"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF44270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="325" mass="34820" checksum="5059DD206275537A" modified="2012-03-21" version="1">MTASNGSNGQATRRPLPVGIYAPTMTFFDPETEDLDIPTIKKHAERLAKAGLAGLVVMGSNGEAAHCTREEKLAVTKATREALDAAGFQNTPIILGATEGSVRGTIELSKAAVEVGADYSLILPPSYFRAQMDETAIHDYFIAVADQSPIPLVLYNYPGAVSGIDMDSDLLIKLAEHPNIVGTKFTCGNTGKLTRVALATNAKTPWSEGSSYMAFGGVCDFTAQTLASGGSGIIAGGANVMPKVCVKVWNLYSEGKRDEAIELQKKLSRADWFLTKAAIAGTKGAIQSYYGYGGFPRRPLRRLEKAKTLYIEEGIKEVMEIENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>H1VXA6</accession>
    <name>H1VXA6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_14129</name>
        <name evidence="2" type="ORF">CH63R_06380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007240">
        <property type="protein sequence ID" value="CCF44868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159205.1">
        <property type="nucleotide sequence ID" value="XM_018301355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VXA6"/>
    <dbReference type="GeneID" id="28865462"/>
    <dbReference type="KEGG" id="chig:CH63R_06380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06380"/>
    <dbReference type="HOGENOM" id="CLU_1896076_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF44868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="134" mass="14051" checksum="88518D19FFC85DAD" modified="2012-03-21" version="1">MQGWAGPHCLIPVGSQGQRKNGLLPRHTRGQTTCEYGAKHNSITCCMALCNICLEWTSVPLKGATPCSLRSSHCVPLDRLGLCPSLISPAVVIHVDCPGPGLHRVGPSHLTVSPTDQPLAIQCSGNETGFCAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1VXZ3</accession>
    <name>H1VXZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">37s ribosomal protein s5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_14296</name>
        <name evidence="8" type="ORF">CH63R_10196</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007442">
        <property type="protein sequence ID" value="CCF45105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154594.1">
        <property type="nucleotide sequence ID" value="XM_018305170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VXZ3"/>
    <dbReference type="STRING" id="759273.H1VXZ3"/>
    <dbReference type="GeneID" id="28869277"/>
    <dbReference type="KEGG" id="chig:CH63R_10196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10196"/>
    <dbReference type="eggNOG" id="KOG2646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037994_1_0_1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="325"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF45105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="489" mass="54938" checksum="ACA0A891EB3BDD5E" modified="2012-03-21" version="1">MNSVRPARSVLSRCVSVSSTPAMPCRLFHSSVSRSGRRRSRFNNITAEKMGLTTPDAIDSYAKRKFPEYTEEEKASLKQKYTPEQWEALEAAEAAIDPRDLVIQGRLRTDPYKQPYVEDFATIRPVIDAKPQKTLQPKEVKWLPRREWVDNYIEKMADRVDTQMHDTMGRAFARALRKVKESNPDKLDFTEEELDELEQNPELRRKFLIDQDPDVLGGKRPRGPKQAGIENNDWMNLIDKHFFEELEQSLSTVENPLQPSRLDSWKAIEGEHGNSALSAELGKVEGVKGLYKPPDDPEDDGLDPTGRFAKLKNATGMKMTDILSVLTKRVVLRSVSNQTRLGKIRSASVVVVAGNGDGRLGVGEAKSTDLHIATATATLLAIRNMKPIRRYENRTIFGNVEAKISGTVVKLASRPPGFGLRVSHRIFEMARLAGIHDLAATIPRSNNPYNTVYAVHKALMNQPDPEEMAIGRGKKLVDVRKVYYGGSVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2019-07-31" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZX9</accession>
    <name>NIS1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Necrosis-inducing secreted protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Secreted effector NIS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NIS1</name>
        <name type="ORF">CH063_03697</name>
        <name type="ORF">CH63R_07994</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IMI 349063</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>IMI 349063</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2012" name="Mol. Plant Microbe Interact." volume="25" first="625" last="636">
            <title>Cell death of Nicotiana benthamiana is induced by secreted protein NIS1 of Colletotrichum orbiculare and is suppressed by a homologue of CgDN3.</title>
            <authorList>
                <person name="Yoshino K."/>
                <person name="Irieda H."/>
                <person name="Sugimoto F."/>
                <person name="Yoshioka H."/>
                <person name="Okuno T."/>
                <person name="Takano Y."/>
            </authorList>
            <dbReference type="PubMed" id="22352720"/>
            <dbReference type="DOI" id="10.1094/MPMI-12-11-0316"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="496" last="505">
            <title>Conserved fungal effector suppresses PAMP-triggered immunity by targeting plant immune kinases.</title>
            <authorList>
                <person name="Irieda H."/>
                <person name="Inoue Y."/>
                <person name="Mori M."/>
                <person name="Yamada K."/>
                <person name="Oshikawa Y."/>
                <person name="Saitoh H."/>
                <person name="Uemura A."/>
                <person name="Terauchi R."/>
                <person name="Kitakura S."/>
                <person name="Kosaka A."/>
                <person name="Singkaravanit-Ogawa S."/>
                <person name="Takano Y."/>
            </authorList>
            <dbReference type="PubMed" id="30584105"/>
            <dbReference type="DOI" id="10.1073/pnas.1807297116"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 8">Secreted effector that induces necrotic lesions in Nicotiana benthamiana (PubMed:22352720). Interacts with the host receptor-like kinases (RLKs) BAK1/SERK3 and BKK1/SERK4, inhibits their kinase activity and suppresses INF1-induced pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) in N.benthamiana (PubMed:30584105). Also interacts with the host receptor-like cytoplasmic kinase (RLCK) BIK1 and inhibits its kinase activity, thereby inhibiting PAMP-induced ROS generation (Probable). In PTI, phosphorylation relaying by RLKs and RLCKs is critical for the initiation of downstream signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal region from residues 103 to 132 is important for BAK1/SERK3-binding and the host cell death suppression.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NIS1 effector family.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CACQ02008057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157746.1">
        <property type="nucleotide sequence ID" value="XM_018302968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZX9"/>
    <dbReference type="SMR" id="H1VZX9"/>
    <dbReference type="STRING" id="759273.H1VZX9"/>
    <dbReference type="GlyCosmos" id="H1VZX9">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCF45791">
        <property type="protein sequence ID" value="CCF45791"/>
        <property type="gene ID" value="CH063_03697"/>
    </dbReference>
    <dbReference type="GeneID" id="28867075"/>
    <dbReference type="KEGG" id="chig:CH63R_07994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07994"/>
    <dbReference type="eggNOG" id="ENOG502S8NB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138726_0_0_1"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000447639" description="Necrosis-inducing secreted protein 1">
        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="BAK1/SERK3-binding" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="N4VG36"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22352720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="30584105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="22352720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="30584105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <sequence length="144" mass="14963" checksum="630B9A026D5EBF2E" modified="2012-03-21" version="1" precursor="true">MQFRASIAAAAGLFALANARIYGIAFPETVKAGDEVEAVITTENYIQAVQDIAIAFGIATEASAYPETLGNALGSFYLGPEESNTLENITETVTIPAGLAPGQYVVAAGLYSLYGASSSPTLSHYNVTVTVGNVTSETYVGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1W0M6</accession>
    <name>H1W0M6_COLHI</name>
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        <submittedName>
            <fullName evidence="1">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_03767</name>
        <name evidence="2" type="ORF">CH63R_01353</name>
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    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008279">
        <property type="protein sequence ID" value="CCF46039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164690.1">
        <property type="nucleotide sequence ID" value="XM_018296328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W0M6"/>
    <dbReference type="STRING" id="759273.H1W0M6"/>
    <dbReference type="GeneID" id="28860435"/>
    <dbReference type="KEGG" id="chig:CH63R_01353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01353"/>
    <dbReference type="eggNOG" id="KOG4308">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_027887_0_0_1"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF46039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="698" mass="76042" checksum="1C828AB1A3AA93F0" modified="2012-03-21" version="1">MASAVTISLPSTPPTLGGFVPRLSSLTQTPATSITNLADSHGDDTGVDLDEAVRLATLCRQAFNLLDVQMLDFNHSKAYTADEILALPMDVLRLPDELHGLPRRKSARSHLAVAIATLLYPATHDNAVSPVIRYEAARVRLRAWVALQRKYDIFAATKRNGHSFRGLTGGAAPGVHAPVWASRILAQGPWNPASFPVALAGTKAIPMPVAVADIADLAPFFDHLGQGGTHELDEKSAGTALDGGKGEPYYGIKAAEFPKGVVYEDGRMDLCKMVVGRDHIGNLMDSLRPNPFVRHFLLGNNIIGPVGAQEIARFIRKLPDRMETWYLAGNCIDAASFKTLVDALIESDAVTNVWLKRNPLGPVAAVDVYRLITETKNIRTLDLDQTELGDAGVAELFHCLTMFSLAVPGRKKLPLRNIYLNGNGISTKAALAIAAFLDSPACGITSLYLSCNPLGDEGAQALASGICQAPQLSRLSLQSTGLTTPGAVDVFRAVKSHPGMRFLDVGQAYATVDLGQAWNYIDSAAVPSICELVTTNQNLEYLNLGHCPITPPELRKIDAAVLTGSLLYYSAESILPDPKEKYPTFNPSADHMMPEMHSWSVPTKDDKALKKAVNNHLEANVKTIYGDGMSYAKFLDEEKRWIVNDKTDVRKIDSVYRNRDAGHARRRLQVLVKDWEENDNTLARVMNAKGPFSTTRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2Q4</accession>
    <name>H1W2Q4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein kinase rad3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_03946</name>
        <name evidence="9" type="ORF">CH63R_07583</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02009045">
        <property type="protein sequence ID" value="CCF46767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157336.1">
        <property type="nucleotide sequence ID" value="XM_018302558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2Q4"/>
    <dbReference type="STRING" id="759273.H1W2Q4"/>
    <dbReference type="GeneID" id="28866665"/>
    <dbReference type="KEGG" id="chig:CH63R_07583"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07583"/>
    <dbReference type="eggNOG" id="ENOG502S5PB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045993_0_0_1"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF46767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="32835" checksum="D7340143DA79A90B" modified="2012-03-21" version="1">MPEYRVEVSPNNRAGCTDGVCKKAAAKCVKGSLRFGTWTKIMDHEAFKWKHWGCVSGEQMAQVRTLCEKGDGTFDFDAFDGYEEMNDHPDLQAKIRKAVEQGHIDPDDFNGDPWMNKTGQRGIRGKKPKDWDDGEDADEAEEEAPAKGKKRGRKSAAAAAAEDEEEEKPKAKRAKKAIAKPDPEDEDEKPKPKARRGKAAAAAVKAEDEDSEEDAPKPKRGAVKKAAAPKKTAAKNPAAKKAKAVVDDEGVSEADIVTASEDDEEAEPAPKKAKAASKGRKKAAATPAAEEKPKSARASRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2Z1</accession>
    <name>H1W2Z1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_00081</name>
        <name evidence="10" type="ORF">CH63R_09028</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02009124">
        <property type="protein sequence ID" value="CCF46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR07507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156025.1">
        <property type="nucleotide sequence ID" value="XM_018304002.1"/>
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    <dbReference type="AlphaFoldDB" id="H1W2Z1"/>
    <dbReference type="STRING" id="759273.H1W2Z1"/>
    <dbReference type="GeneID" id="28868109"/>
    <dbReference type="KEGG" id="chig:CH63R_09028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09028"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010965637" description="agmatinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="398" mass="43241" checksum="6EEC5304CD7641B8" modified="2012-03-21" version="1">MVSRSILALCLAATVYGHGDHDDHQKSIAGPHKSLWYNTLPGDGGTQADSVFSGISTFGRLPYQPCLGAQDVRYDIAFIGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNVPLATNPFNSWATVLDCGDIPVTSYDNTWALHQIEEGHFNILSRQPATDAAKKGPAKNERTLPRVITLGGDHTITLPLLRSINRAYGPVSVIHFDSHLDTWRPKVFGGSPSEVASINHGTYFYHASQEGLLRNDSNIHAGIRTTLSGPSDYENDGYCGFEIVEAREIDTIGTDGIIKRIIERVGTKNPVYLSLDIDTLDPAFAPATGTPETGGWSTRELRTILRGLESLNLIAADIVEVAPAYDTNAEHTTMAAADALYEIMSIMVKRGPLSAMVNQTEAYEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4D1</accession>
    <name>H1W4D1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04128</name>
        <name evidence="3" type="ORF">CH63R_12303</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009612">
        <property type="protein sequence ID" value="CCF47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151694.1">
        <property type="nucleotide sequence ID" value="XM_018307277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4D1"/>
    <dbReference type="STRING" id="759273.H1W4D1"/>
    <dbReference type="GeneID" id="28871384"/>
    <dbReference type="KEGG" id="chig:CH63R_12303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12303"/>
    <dbReference type="eggNOG" id="ENOG502R6AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134555_0_0_1"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556576" evidence="1">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF47344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="122" mass="12709" checksum="9AFBE8929B6D3BBC" modified="2012-03-21" version="1">MQTKTILFAVLGAMTASAASIKRQNNGADFGTCTPTMDFQLGRAGRKADQGTFLPTDPVVAKGQQDALNPNIITNRICDQLTNVCKANQAAKDLCQQAKAQVSAAGVKDASAATMFNGALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5L6</accession>
    <name>H1W5L6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_04279</name>
        <name evidence="14" type="ORF">CH63R_04760</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02010134">
        <property type="protein sequence ID" value="CCF47780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160981.1">
        <property type="nucleotide sequence ID" value="XM_018299735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5L6"/>
    <dbReference type="STRING" id="759273.H1W5L6"/>
    <dbReference type="GeneID" id="28863842"/>
    <dbReference type="KEGG" id="chig:CH63R_04760"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04760"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_4_2_1"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002127">
        <property type="term" value="P:tRNA wobble base cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="487"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="817"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="831"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="183"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF47780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="868" mass="96718" checksum="864AF4DFD2A453CE" modified="2012-03-21" version="1">MGRKFRGGKKGKGRGGGNATGGDRGRQPRSESWQSYPAVKKENERLQRYYNTIIGLSEEEQVPFWDALRRDLPNSFRFCGSKGHALAVKKLLQSRYMPEIEKIEHADGRAVEPPKPLSWYPNELAWWMTTPKNIIRKYPPFAAFQKFLVSETTVGNISRQEVVSMIPPLLMDVRPGMTVLDMCAAPGSKAGQLLEMIHQGEEARVRKVLRAFAKEDGLDLGEETEEERQADLEADPADAGRTTGLLIANDADYKRGHMLVHQLKRLGSPNLLVTNHDATQYPSIKLPSDPATPNKPQYLKFDRILADVPCSGDGTLRKNMNLWKDWQPGSALGLHVTQVRILLRALAMLKVGGRVVYSTCSMNPVENESVVAAAIDRAGGPDKVEILDCSNELQGLVRAPGMRKWQIMDKSGRLWGSQAEVDEYTKNSADGIAPGRIVDTMFPPVEGSVGADIPLERCMRVYAHQQDTGGFFITVLQKKAEVKIRPEDQKIDDATKSNGNTAAATPVAEETKPEENTEEKTEAKTEEAPAATETGKPEEKSEAKATTEADVPEQDAINGAKRPREDDTADGETQETKKPKLDATQEKPKRSNRNIHGQVEEPFKYLDPKHEVIKNIKTFYHVSSRFPEDRFMVRNAAGEPAKAIYYTSALARDILVENEGRGIKVIHGGVKMFMKQDAPSAEICRWRIQSEGMPILQGYVGEQRVVRLTTKETLRRLLIEMFPRIADGEWEKMGEIGARVRDIGMGCCVLRVEPDGSDPAFSERMALPLWKSIHSLNLMLPKEDRTAMLLRIFNDTTPLINNSLQKQRQIDEAARVKAAGEASAAEKENVDTEEANDTEDVIDIEDAPTPEEMDRDEPEPTTTATENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5P7</accession>
    <name>H1W5P7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_04290</name>
        <name evidence="2" type="ORF">CH63R_05108</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02010178">
        <property type="protein sequence ID" value="CCF47811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161329.1">
        <property type="nucleotide sequence ID" value="XM_018300083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5P7"/>
    <dbReference type="GeneID" id="28864190"/>
    <dbReference type="KEGG" id="chig:CH63R_05108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05108"/>
    <dbReference type="HOGENOM" id="CLU_2497775_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF47811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="86" mass="9425" checksum="70E2F168A9FC4CE6" modified="2012-03-21" version="1">MYWFRAAVLHNHCVLGTQWSTVSRNSPTDCNPPCQGNLDTDQRVLGSRCSAAEFMLEQSGLPSTQVTTVLLRSPIVAVKRCSTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT62</accession>
    <name>A0A1B7XT62_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_14176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151468.1">
        <property type="nucleotide sequence ID" value="XM_018309150.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873257"/>
    <dbReference type="KEGG" id="chig:CH63R_14176"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14176"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="300"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="693"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR02950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1324" mass="145980" checksum="D8A151DCCE945CF7" modified="2016-11-02" version="1">MRKSHYSVSHRKPSWKRLFAFSKLHHLPTLVAGIFATCMCADLRTAFAVVIGQMFQIISNYGSEVSGSSDTITQASQLSITICCLGAGILVGNAVVLSSWVVFGELQAKSARTSVFSRLLAHEMSWYDMRTDGIPGLLARTEANVPGLWVPCGRHCYLDCITRPGLECHLEVDTRTRCSVPFAAVALSLTSRGLHPAIMQQKAHLADASKLVHACVTGIDLVKVFNGFSQEMRTYSKFTDGSMELHLLQARCNSIQMSVTGFWVSAMFAGGFWFGLWLVTKGENASAILISFYATLTALEAIYNVSFAYPFEPTQLVLKSSSFHFPAGETRFVLGSSGSGKISWSTFTEALLGEIFIDGRPLKALEKEWLRKNVTLVQEDSMVFNNTLLWNITLYQQVTTDDVKAACDMSLLQSTLTSLPFGTETRIGPAGHRLSGGQVQRLALARESKLLVMDAVRAWRRGKTTIIITHDVSQFGNNDYVYVMDRGRVIREGTRDGISKGLDGRFASLITCSDEAGGQQRANENVCGNAPSSCSFNSIVDQTTNAMLHQSRSGEGRRISLGVSLGAALLSTDIWAQSKDRQNTGFRTEEPAFQHISQGGLQSNQVPEPPVSSGRTSLEAIQAAGRFVQSTRQNKPTRRRWQVGGHVEERVNTCKREEKRTMNEPPYLVTKSTWAVIQTVWPNLASENRIRLVMGLVFCYVAGRCAPASSFCFAQLLTVFWATGDRFTAGQEWAVFLILVAVLSGVSLFLGRYFMEHVGQVWANTLRLEGMKRTLQQQRPWFHEPDNSARHIVETLDRHAEEMRNLVLRFVPIFLMIIVIVTISTVWALLISWKLTLVALSRFPVVVAALPALSVVDTKWEAVCNRGAAETASITQEALINIRVTRAFTLEKYFCTQHAQSAKSTYGLGLQSGLLLRPLFGFSQSIDFFVVALICWYGMYLVAHELEMSAINLQQVANLLLFCVGQTAALIGMIPRVSASQAAATRVLFLATFTDQNVLPTGGSRRPTSLFPVKMRNVTFAYPSQLTHQVLRNVNLCIGNGKCVAMVGPSGCGKSTIISLLLRLYGQIWLGPTGGTKSGQLTFGGIASDQINKEQFCSHISYRISLTDCQKLRLGAKAPNLIRAARKAGIHEFITSLSQGYDTLVGDGGQSLSGGESQQVCIARALAGRPRLVILDEPTSALDNASADLIRRTIIDMLASAEDREMSVVVATHCREMMRIAQRIVVLEAGRVVGEGTFHELQSHNMAFSALVNQEFIHHMRRGSDDIRPMYDLLPDVMLHRSDMMLSAIQAREVPHSARAIDLSFRRVPSAQRGQWGRAMQPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTK9</accession>
    <name>A0A1B7XTK9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151623.1">
        <property type="nucleotide sequence ID" value="XM_018309305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTK9"/>
    <dbReference type="GeneID" id="28873412"/>
    <dbReference type="KEGG" id="chig:CH63R_14331"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14331"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601054" evidence="1">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="296" mass="31240" checksum="6E8DB5CB5F829EB0" modified="2016-11-02" version="1">MFNYKTTSLLTLGLLGLACMPSAVAAPLAVEELEWPTQYVQSGQTSTRVLVQGHGPAVVIVPSYGRDGGDDFNGLTSALVNAGYLVLRPQPRGTLGSSGPMANVTLDDLALDIADVIDTIAGGRAIVFGHAFGTFVTKRVALNYPDKVPAIVVASPGGQKIPEDIAGMPFVAGNTSLPVATRLAALELAFFAPGHDAHIWLDGWYPDTLAMEHGAIEAAGDLTKFWAGANSTQVLELIPAEDPFQPEDQWNTTANLFPDRAVSVVIQNASHALLPENLTGVVEAVLPYLAQQSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV73</accession>
    <name>A0A1B7XV73_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LSM1</name>
        <name evidence="6" type="ORF">CH63R_12765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152156.1">
        <property type="nucleotide sequence ID" value="XM_018307739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV73"/>
    <dbReference type="GeneID" id="28871846"/>
    <dbReference type="KEGG" id="chig:CH63R_12765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12765"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="210" mass="23342" checksum="8FC55B1D73CA7D92" modified="2016-11-02" version="1">MENLTISDAPPQGAQPVLGGRAPPPQQTPQLPPQMFTTAAQLLDMTDKKLMVALRDGRKLIGVLRSWDQFGMYTMHARYRHPVMARGNLLSVRVSGRLTRRSPANLVLQDTVERVYAYPDLEANPPREGGMFADIKRGIFLVRGENVLLLGEIDLDKDDDPPPGYEPADLKLVQGLAAERKDKDKARDKGRIKKLSTLGFEGENMGEILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVF8</accession>
    <name>A0A1B7XVF8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flap structure-specific endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152241.1">
        <property type="nucleotide sequence ID" value="XM_018307824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVF8"/>
    <dbReference type="GeneID" id="28871931"/>
    <dbReference type="KEGG" id="chig:CH63R_12850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12850"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="61"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="694"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="734" mass="79464" checksum="5B516295CE57F3FC" modified="2016-11-02" version="1">MSSGGTNPAIRTLFYRLVRLLSLGIHPIFVFDGPHKPAFKRNKRSGRGDGVATAMAKRVTRLFGFPVHDAPGEAEAECALLQQKGIVDAVLSEDVDTIMFGCTRTLRNWTAEGTRGSKTPTHVSLYDVNALLSTGTGLDREGMVLVALMSGGDYLPEGVPGCGVKLACEAAKAGFGKSLCRLKIDDDIQFEEWRAKLRHELRTNESGFFRVRHKALSIPDEFPSRQVLRHYTHPVVSNSNTVNKLKTDVNWGNAIDVQGLRYFVQETFDWVNKAGAVKLTRVLSPGLLDEVVSFDRQGLALNSDDDLEATIDGDAETAGGKTRTNSTFDPNVPELIWLPETLVKISVPLTVEDWEEKQRSKALPRPSSKTVKTAKTAKTTKTIRTTKTAKKSASTAPHEAGALDKWVQITKTTGTNPSTTSQDKYFDDGDIQLPPLARSTLRGSSPPLHSSASVSASSQLPTPLQSSVNLSKQSRSNGKATAGVEPTGHLGAWAHVGSQHMPRITKSQHPAKPIILSSSPIRASSAPTRPSLSPPSPQHIIDLSGPDDATLIKASKSFDTFSSPSQPSTMTQLARGPSPALSGIPSDNKQSMKQTRMDSFVTNLPDKPLNVESLTHPNTRESNGALAYISASQTVKPSSLGYNDTSLNMLRITKPLARWIDYDDDDAPPPMEGTSGRARRMAVPRKSVGGFFKVIDMSDEHEKNGAKPTPSKRSTTSACRQSEVSIIDLTGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVZ8</accession>
    <name>A0A1B7XVZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152465.1">
        <property type="nucleotide sequence ID" value="XM_018308048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVZ8"/>
    <dbReference type="GeneID" id="28872155"/>
    <dbReference type="KEGG" id="chig:CH63R_13074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13074"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="358" mass="40472" checksum="7DB56264ED8563AA" modified="2016-11-02" version="1">MADVQEGQQRPEPVETIIQEPQDAEDDTYASSLDGASVQSDTDSLKSSIRDYRRENGRTYHSVSDGNMQHHCWQLTWDDKLCMSPKKDGANRVLDVGTGTGIWAMDYADDHPEALVIGVDLSPIQPEFLCLGEYGPKTPNGVLTDLNSVPPNCRFEIDDVEKEWTWQEPFDFIFARHMNACFASWEKFLKQAYDNLEPGGYIELQDNAFPILCGDGTLKPDDAMARWSTLMMEGTELIGRPITVPADFRRLLGEAGFEDVVEHRRVWPTSPWPKDEALRRLGFWTQACSLDGVEPGALALFTRVLGWTREEVLVFIAGVRNDFRNKDIHAYWNVYSVHGRKPLKKKPTPTPPPSAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW69</accession>
    <name>A0A1B7XW69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 6A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_13107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152498.1">
        <property type="nucleotide sequence ID" value="XM_018308081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW69"/>
    <dbReference type="GeneID" id="28872188"/>
    <dbReference type="KEGG" id="chig:CH63R_13107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13107"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="521" mass="58488" checksum="076029870A3552BD" modified="2016-11-02" version="1">MSLAAAVSAALRPQSWPTSVWVLLLTGLAYAVGSLAWRPSFPRNAPRLLKGYPVLGTPRFFSERGNFLSEGRRFAASGNWSFYFGKMRIVGLSGDEGRRLFFESRDLDFTKGLNFFNRRYGALFNATPRIDVSKDRSSGDDFGAKFNWNLVKLLRRDVLSSRLPLLINDTRKSMDAIAARVDPASGFGTSDPFDDMYQLVFQLTMRMVGCDEIAEDPALMVRVLRIYESIDAASTATKIMFPWMPTVGHLRRVYSGAKMYMLLEGFIKQRKERGVGNDDALQFLIDNGDSTAEMVAFMVGALFAGLINSGINAAYLLCFLAADERWYAAMRDEVDGAIARRRRSEAQTPEEILAGMSMDEWEAEFPLIDVGLKETIRLTITGCGFRYNASGRDVAIGASGEVVPADAYAVYHFDTTHMSPDFFPDPLRWDPGRYLPGREEDKKDPHAFIGWGTGRHPCLGTRFAKLEMAITTALFIARFDFRLVDAEGKKMKKVPENSVDRNAHSASKPREKMFLRFKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX71</accession>
    <name>A0A1B7XX71_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152858.1">
        <property type="nucleotide sequence ID" value="XM_018306017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX71"/>
    <dbReference type="GeneID" id="28870124"/>
    <dbReference type="KEGG" id="chig:CH63R_11043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11043"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01309">
        <property type="entry name" value="Met_dep_hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="209"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="964" mass="103970" checksum="088A06D57784ED17" modified="2016-11-02" version="1">MVNMESEKSGLLPPYSAAAVTPPSGQRPSQHHRKRWLRPSRSMKLIVGCLAFIAFAQWKQLSLLPSRQSSSNLSVDRLQQDLSTCAKLRHKPQDPIGLGREKNARYVDGQRPTLIRNATIWVGEAVEGTSPEDARAGKGYSWITADVLIGQGLIQKVEADISLDSLPEDIQIWDAKGRQLTSGIIDMHSHAGVGALPELNGNQDVNELSADITPYVRSIDGLNPLDPQIQVIKSGGVTTSLVLPGSGNNIGGEAYVIKHAVGKADGRTEFSAEDMLADPDRNWRYMKMACGENAKRVYGKIGHGPFSRLGESWEFRHAFEQAAKLVQEQDDWCAAADKFGVESQTSYLPQDLKWESLSAALRGQVHINTHCYTIPDLEAFVDHTNEFKFPVRAFHHAHQTFLVPEILKRVWGGRPPASALFADNMYYKSESYVGSEYAGKILWENGLTPVYVSDNPVLNAQHVLFEAAKAYRYGLPYHAALSSVTSAPAELLGLGQRIGKIKPGFDADIAVWDSDPLSVGAAPVQVWIDGAAQFSDPFELKKPLTGPISPDPKLSNTTEETTDLEEVVFTGVSNVWLSDEDIRTGGDETVNVVFADGAIKCIGACAEEVATAKSASKRVIDLKNGHITESFTAFGSLIGLNEIDNEGDTDNGRNPTGFSRGLDGLVLDNKKLHVAKRYGVTKGISAPKFTGGLTHSGTSVGFNTDARHALEKGAVWSEDVAVHRTLTLAAKRGDNPSISSAVGELRHSLLEAVATNDTGSDPFSEAAYLKKVVNGDLPLVLTIHSADAIVAALRVKATVEEALAAKRQSTESTKLRVAIIGGAESHLVASELASAGVGVVLAPFQSYSTTWDQRRSLTGAPLTNGTAIDTLIDAGVVTAIGLEEDWLIRDLGLLAGIAQKNGNGRLSEKKALDLVSTNVYKILGIEEQQSRKARHFVVYEGSPLEIGGRIRAVGSGRDTVSVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXT1</accession>
    <name>A0A1B7XXT1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153101.1">
        <property type="nucleotide sequence ID" value="XM_018306260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXT1"/>
    <dbReference type="GeneID" id="28870367"/>
    <dbReference type="KEGG" id="chig:CH63R_11286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11286"/>
    <dbReference type="OrthoDB" id="10335943at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="144" mass="16338" checksum="35296D6B158846D2" modified="2016-11-02" version="1">MVLFLVSKALPPPPPKKPSSPLTSYISLVHLVPFKTASLIRILLKVPSNLVEVSFPNGRPQPAVFAPENPPFTRARATFFLPQFILFHYARVAYLFHRQQIPEKPFVQFSFCLKSCVSILSTPHISQKKLIEKLGFPPPPRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ34</accession>
    <name>A0A1B7XZ34_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153534.1">
        <property type="nucleotide sequence ID" value="XM_018306693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ34"/>
    <dbReference type="GeneID" id="28870800"/>
    <dbReference type="KEGG" id="chig:CH63R_11719"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11719"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="50"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="33800" checksum="DF834F8C488E3A04" modified="2016-11-02" version="1">MSPTTLHQGATKGFADAATYDAYRPSYPPGATQRFLSHLRLADVPHARVLDLAAGTGKMTEVLAARHEGFEVVAVEPHEGMRAELERKGLSGVEVKDGFASRLPLDEEWGDGAIVAQTWKWCMPPDSYRTTRFATPESLKEIHRVLKPTAVLGLIWNIEDYNKPQHWEASTPWEKALNELVFSLGSDGQPRFRDFVWKDVFDSQLDSNPLRAVKDVVLEGGRKMPLFSVPVGEEKVPFTTWLTPEAIWNRLRTLSQVAVLQGEAAGAFKARFDAILGGESVERNERGEVALHGVTYFAWTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0S0</accession>
    <name>A0A1B7Y0S0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf1479 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154103.1">
        <property type="nucleotide sequence ID" value="XM_018304679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0S0"/>
    <dbReference type="GeneID" id="28868786"/>
    <dbReference type="KEGG" id="chig:CH63R_09705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09705"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="502" mass="55553" checksum="FCF221067949953A" modified="2016-11-02" version="1">MSRLITLSRCRTTSLLRLQPQRRTVMMGTAASRHGPKKEGDISSVFVSLSGTTREPLPDRFRTLKQDLVAGHEDAVVESWGRLVRALREENETVAVKGPAIIPSVDFQNIDEDIDGLKADIRKRGAVVVRGVVDEKEARGYKEEIEAYVRKNPSTKAFPADNPQVYELYWSLPQLRARAHPNMLKTQATLIRELWSAPSAGAAISMQPLTYSDRLRIRQPGDATFALGPHIDGGSVERWERDGYGRGGGTYDAVFRGEWESYDPWDVTARLEAVQDLYNGAGACSMFRMFQGWLSMSASGPREGTLLVNPLVQLSTAYFLLRPFFQPRRTASDVGTEAFLREDNWAFTGGNEMTSELQGATPGHGQELSDALHPHLRLGETMVHVPRIRPGDFVVWHTDQIHAVDTVHQGRGDSSVIYIPVCPATDLNVEYLARQREAFLSGLPGPDFPGGKGESEHVGRPGEDAIRGAEARRAMGLEKLVAIGEGQAEREMIERANRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2N4</accession>
    <name>A0A1B7Y2N4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tpa inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154790.1">
        <property type="nucleotide sequence ID" value="XM_018305366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2N4"/>
    <dbReference type="GeneID" id="28869473"/>
    <dbReference type="KEGG" id="chig:CH63R_10392"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10392"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="648" mass="68928" checksum="6A9033AD06BBB4BF" modified="2016-11-02" version="1">MAQPQPQMPQRAFSPPQPSPSPAATQAGFALPPNKRPRLSPGATPQPESPYSTSPYAASPGAPVTPSTAATSAGSPIYPSAAQQQQQQPPQQQQQPQPQQPTTPGYATPYANGTTTPALALPDTRPTPPPQVTTPQPPAPPTLPQYTTATLALGTNTPGTPVPQQPSTPGAMGPPSRPPDRPQKEYEYDVTDSLAGTGIDLRAEEQFLSELYVPESRTGYPPYPPGNKGSFYGAGPANQPAQPAGTDAQSQLVAQAAEKAWQESAKRLAQTRTMELNNAFLQVPVVFRKAEKFAKDQGLSLNLEIKNSNQPMGRMRLPEEFPAPSVTVSTKNGPDSTVVTTSGTWIPQEAFLVDQLALLSLATKQRLRTLMEDSNRIAQIRQVSSHGEIPEEWQTAAAPLKSATETQEEDATQQTATEDGASPRPGNLKRTLEDATSSQPTKVQKVSATNTMSHTVREVGKAERDWEERRLRRRNARKDGTTEAGATPSRAGSVAPGTPGGSAPDSEKSISKKEQKKLDAVKKAEASSHANQNITSSMFVGMPKTGSLFGKKKGGKSYSWMTGGASGSSTPRMGTPGKPGGAAASGPPAPANHALTVEGRARLGNWREDKEKGKNIQLRDWVAALEGDEIELRAMQAAYDKLDTSDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y467</accession>
    <name>A0A1B7Y467_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155339.1">
        <property type="nucleotide sequence ID" value="XM_018305915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y467"/>
    <dbReference type="GeneID" id="28870022"/>
    <dbReference type="KEGG" id="chig:CH63R_10941"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10941"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF4">
        <property type="entry name" value="HYPOTHETICAL AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="593" mass="65123" checksum="5A9738222597AC96" modified="2016-11-02" version="1">MSLAQHVTQAEGFDYERPPQQVDGNDNDEAVPGTGQPGTTEISHEDPQWRQLNFAPVETVHAEKPLAAYKVSNAKRWVQVVTGIVACWLAAGIVFGFAALKPVLVSEGVYSDLCDANDPSSVEDGEYIPCIEQDLRLNLFFIAASVTTNVSSLLAGSVLDRYGRRVCWIVSSICLIVGCVLMAASHNFTSFDGYFLGNIFLALGGTFVFVSSFQLANAFPKYSGLIIALVTGAFDASAAVFLIYRMVYEATDGKLSLEKFFYAYISIPVLILIAEVMYMPVRSYHTMPQLEQKIEKAQDESRDVHESDEEIDDARQLRKVRSARADRRLSKLDQIEEVAGDAEQREERVKISEERQEASGVWGVLHGVPAHRQIQSPWFTLILALTIVQMLRMNYFIATIRAQYRYMLGSEAEADAINRFFDAALPIGGLVSTPFIGILLNNLSVPTTFGVLTVLIVAIGVFNCLPFGWAGYTTVILFVIFRPLYYSAISDYATKVFGFATFGRIYGTIVCVSGIINFAQSGLDALTHGPLHGDPTPVNVTLGCAGAIVGVALTVFVSIKGRIFVKEEKPALDAVEERQRLLSSAEGDYGSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4Q2</accession>
    <name>A0A1B7Y4Q2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155529.1">
        <property type="nucleotide sequence ID" value="XM_018303506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4Q2"/>
    <dbReference type="GeneID" id="28867613"/>
    <dbReference type="KEGG" id="chig:CH63R_08532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08532"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="152" mass="16574" checksum="69FD63C15B4C2DA5" modified="2016-11-02" version="1">MITHFLPHLQSLRSSITTSSCSIILVSSGLALVPIPRCPNYCATKSALHSLAWSLRAQLAAHGPSAHIRVVEVVPPAVRTELHSQQPDLVAAGQADFGMPLDEFTEETWAALLEGNEDEIIVGPAKNFAHVEMDRKKMFDKITESFNNGNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5C1</accession>
    <name>A0A1B7Y5C1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155711.1">
        <property type="nucleotide sequence ID" value="XM_018303688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5C1"/>
    <dbReference type="GeneID" id="28867795"/>
    <dbReference type="KEGG" id="chig:CH63R_08714"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08714"/>
    <dbReference type="OrthoDB" id="5408998at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="95048" checksum="883B6A439EE0D0CB" modified="2016-11-02" version="1">MATRQTDVDDVPPPPYSETDIYSTSGQRSHPSSNSPRIPSHHGDDADSRVSSHASSHSEVIYTPPLTPRTTAAAAGPHHRDSNPNLSSGPPQFPVAAPASTSSVHSEFAAAYFESRPAPTPSPRDQLVHLFTVTPSTTPDDIPCPPTWAVRDVTRQDWATFTNCLIPHHTAARNEAVINRKLQAEEEAIAAAAAAATSHGGRAGNTSSGARSNSSSHASAQLDQIRSDPVTDPGAAAAVSGLRREDVEAVIAQWNEGFFGPRGVAVALHPTVDELRMPGAWDRSFDRNVESPSIPGGGSGGPMRGSFPVHPGPGLSESANEPRGSWSFGGITVTPDGISIGDRIVARSNGIRVGNLIADENGIRFGSNTTPRAQPHYVGPNSSWTPPHPPIPPAPPAAPAAPAPPPQMFGPGPGPGPFPPGPHPPQPLGHPGSHEHPFFTGGHSHAHAHAHTHFRHDSGSRGRGRPPAKHPSDQRSSSTSSSFSSSSSTSSASSVGSLPDYEDLYAAQLPVYQQRVASWLAHPDQPVSRADIAQLREEIRSAPDAPGQQKQDGGPTTASAAPNTADEAALKAELKALTQEWRKLKRLQRAARKEKRRERRAKRREEKRDRREQKRERREQRREERREQRGTRRGGGGGGDGGARGSHQHQQQHHQQQHHHHHHHLGPGPMPAPLPWGAPQPFVPQPPVMHTPPIPAVPIVAPNVPNSFPWGSGPGRGFAPSGGFPGGGGPWGTGFGTGWGRGRGHGPGHGGERAFPFTGGPLHPSGAWPVGSGGGGGGGDDERSPGASTPALPPSQALFKAVEEMEMDIARRVDELDKLRNEIRGGSTVGGGRDGNGRGRGRCGWGRGGGSGGRADEEARRMEDEIDELSRNVEKLRVEADAEFARELAAEDGKSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5D4</accession>
    <name>A0A1B7Y5D4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155726.1">
        <property type="nucleotide sequence ID" value="XM_018303703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5D4"/>
    <dbReference type="GeneID" id="28867810"/>
    <dbReference type="KEGG" id="chig:CH63R_08729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08729"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="559" mass="61970" checksum="B08025E3C7EAC946" modified="2016-11-02" version="1">MLPAGSTYLVSDDGGPDRTKLRPVGSEMWSSLPALTVIGRNSAGRPDEVRNVDVTCQVPPTTTYTKYSTSSAISMSATLGRKKSCASCRISKARCSLDSPCRRCEERNLDCKYDHPPRRPAAYRALRPLQTPEGSSRRDIEETRSHVERSTHRRSPPPGPLMENHIDHLDGPSMNWDTLLSPSFLQLSPGCELGFSSLLSPSSSDMRLNTFQGLQAPPESGGVPWIRNGQQSGVPDHPEARSSLGSPPSIPTARSDRLQTQARTCLSRPPRRPFYQDRPFALRPNKVVAACFTVKVLMGQLLAYPKMMAKGGRLPPFIFPPCVVEGNALTTDCCSTGYHKCLPETLAICCNLVQSFEARTAGSASFVWKSIYKEVGRLQNEAVVIYILLQAGDPDSVPYNDIAALVSAPESIAKSLHTSSDYTVNLTNSTKIDRREWVIRESVRRTICIIFGVQLMLDVDFNVAGGECGGYSQLPLPSGRELWETVSNDEWAARYRKLHARYRDDNVLNIQDLRRARRALESDITDQSEEGRLVGRVAEWCESLDELGMMVWMAVMQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5E5</accession>
    <name>A0A1B7Y5E5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155732.1">
        <property type="nucleotide sequence ID" value="XM_018303709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5E5"/>
    <dbReference type="GeneID" id="28867816"/>
    <dbReference type="KEGG" id="chig:CH63R_08735"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08735"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="29558" checksum="3274AE97A3106E06" modified="2016-11-02" version="1">MDNDTNMGEVPASRLLDPQIFEHLKDKIDEDQQVRDQMSQTVQKLDRAISYVQGLLSRIHATPREQYPSLLSDVQAGIQKEIEVIGELEEIASKHPYYKYNQKWNRQVQNAIFTVLLCGWLGGLTSDGKPGPIARLLTLEEVGSIFKVPVNLKDRDAFHLTIEEYLLALTDLTQELSRLATNAVTLSDFAMPVEISSFVKDLFAGFQLLNLKNDILRKRVDAVKYDVKRVEDVVYDLTLRNLIPQKKKEVAVAESSSAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5K3</accession>
    <name>A0A1B7Y5K3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155796.1">
        <property type="nucleotide sequence ID" value="XM_018303773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5K3"/>
    <dbReference type="GeneID" id="28867880"/>
    <dbReference type="KEGG" id="chig:CH63R_08799"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08799"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="550" mass="60161" checksum="B491127FB228FCC6" modified="2016-11-02" version="1">MADSITEKEKIAFPSTPVDDGLGKSTQEVTLTKDGFSVHPQPVPGDAMDPLNWSSFQKHTILAIVMALYFMFTYITTTTVPSFPELQDQYSLTLEMVNWTVAIPALGLAIGPLLWSSLADIIGRRTIFIAGTIVAFAATIGAAKAPSYGGYMAARFFQGLGVSPAATVGLAIINDMFFEHERGQKVGLWVLAIDLGLLTGPLIGGFVDLVDHYWIQWLTAIFFAVILAAELAFLPETLYPRDYMLSRTSGVGAVPATGGVVDEKTFATGTATPDSLAVLRTKKLAFLNVKPVPSVKHPKAWASIVRFGKLFKYPVVPIATGVYCFGWYWWVLSVITMIPVAYADYSPQTQGRRKGNISNEGSDKSLFFIGLIVGTLVSEIFFSGKLSDWLVVELAKRNGGIKTAEMRLWLAYPAAVLTSVGLIIWGVSIDNAYHWMVGQVAFALFGAGIQMGNTVICSYIVDAYPLQSMAVITFYAVLLNLSAFIDPFFIAPWVTNVGYTWTFAGHGIITIFFCIPALALLHLYGGKMRQKAGEPEWVNPEYDHDIMRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Q8</accession>
    <name>A0A1B7Y5Q8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155851.1">
        <property type="nucleotide sequence ID" value="XM_018303828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Q8"/>
    <dbReference type="GeneID" id="28867935"/>
    <dbReference type="KEGG" id="chig:CH63R_08854"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08854"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601361" evidence="1">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="567" mass="61932" checksum="0778853BE8786C62" modified="2016-11-02" version="1">MKCHSPIILATSALIFANPATADWQFRSRPDLAPPRLNITIPASAVEPGYLFLAPFAGLPDTPTAQHGPRQAGPYILRDDGDLVWSGYAIYSIWATNFQAARWRGRDVLFSFEGDHNAGYGHGHGHVTILDQHYETIRELRAGNHKLVDKHEFHVVNEETGLIQIYQPVPRDLTPWGAEPEQQWIVNAIIQELDIATGKVLFEWSSLDHVSPDEAILPINPGQAGSGYNSSDAWDYFHINSVDKDDQGNYLISARDACAVHKINGTDGSILWRLGGTNSSFALGDGVDFCFQHHARWLSQASDGDDDDGQEVISLYDNSAHGTEHDSGGEVHTAPTSSGKIIRVDTRTGKAELVQGFYPPDGLRSKSQGSTQILPGGNALVNWGSEGAVTEFAADGTPVFHAYVDSGALGVGVENYRAFRFNWTGLPSEEPAIVSLEDAGGTTLYVSWNGDTETKTWRFYEVSDKHGSREFLGEAKRRSFETSLRVSGRRVNEAVAEAVDERGGVLRGTGIARIEPEVLPITAGKGRQVPRPKVSEGEPVEGAPGKVKGLWEWSAIWIAGWRKTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6I2</accession>
    <name>A0A1B7Y6I2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenium binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156093.1">
        <property type="nucleotide sequence ID" value="XM_018304070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6I2"/>
    <dbReference type="GeneID" id="28868177"/>
    <dbReference type="KEGG" id="chig:CH63R_09096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09096"/>
    <dbReference type="OrthoDB" id="10033702at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601380" evidence="1">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="51917" checksum="2824B454B00E06E6" modified="2016-11-02" version="1">MLSKTSLVTIASFLLSPVAAGPVNANDHSPADKRSPLGISLPPLIPSIPGVTEPLASNAPPLPVLQVPTPPLDSPPFAGANIKPKKIGYFWTGAGDNIHKDFLVTASLDDDTFGQIIGVTDVPTSGNSPHHLGTSLDGKTLIGGGLLSLLKTQDTAFYFDVSNPYAPKFKKSNRALLSSIVDEIRAKPEGGFFITYMGSAVGTSPGRLVETNAEGDIIHEWPEDVAGTLNILGEQFSPHGLAVDFNKGIILTSDFVVPLSILKPTLGIQKASTLRLWNLSDRTIISTITIPDGLGIQDVKFIPGNPESAAIATAVGPGQVWIIYPFRRDSSGKQGVAELLYDLGPKAKDSLAIYSDITDDGKFAYFTITLGNHVAALDISDLNNVKRLDDPNETQPIIGPHYVKISPDKKNLLVTGYFVQAGEISIVNTPGDYKGHWLDILPDGSLSFNRSIDFENIFTRDRGGARPHSSVIFDLTDPENPKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6I6</accession>
    <name>A0A1B7Y6I6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156151.1">
        <property type="nucleotide sequence ID" value="XM_018304128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6I6"/>
    <dbReference type="GeneID" id="28868235"/>
    <dbReference type="KEGG" id="chig:CH63R_09154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09154"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="193" mass="21901" checksum="B1616E44FD3873CD" modified="2016-11-02" version="1">MVPRLSSGPELAYGGHDPIIHVVAIQREIPLRIIYASVGWQVDGAQMERCRARLRTHLRRNLGTARGCLWHAAQIYSLSRSLRFSACHFSLSLCIAVSYIFLYDQVVQFPSSQGELIRLDKLVQKSQVDAWVKSVDDSRVHITGIGILDNYESSRRLLLDAETVLRSQKSWQTFAEAMARTFAQMSQGQQPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6T8</accession>
    <name>A0A1B7Y6T8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LIM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156249.1">
        <property type="nucleotide sequence ID" value="XM_018304226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6T8"/>
    <dbReference type="GeneID" id="28868333"/>
    <dbReference type="KEGG" id="chig:CH63R_09252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09252"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="553"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="682" mass="73158" checksum="5D4482463EBA7AAE" modified="2016-11-02" version="1">MALPRESSFMPAIKCSSCGLQVEISMMGEHICSGPGAEPSPPPPRSDSIGSYGQPPPLDNTKYGRMAPPTLDTSAANLPYSRQDQLTPISTSTGSISISPKTPNSQAHGRSDDYFQPQIANDYNSNQQSRRPGGYGGFDDGDDFGSDQMYPNEQRKQAPSLLQRMNTIAPGPFEMGKRPGGARAAAKNAFTPARQDSLTPEDNMAGDRPLTSASNNSSISSGSSNAGGIAPPRLPRKNGYGGFGPPGTTPDEIEPEAFVTRAGTFPRPNESAELHVRTPSAPGTRSDRLRGSPGPGEHERKPSMGPDTSRPPPPRKSLLRPTTAGRDGAPPVDLANEFGAANPYHTPSASTSSGASLFSHGRQASSQSSSQSSPANPRSRRNPSDVNNLDNLMNDIESSMAAMHSPKDEMPPPPPPKPAAQSQPSRRAPPSVDLRNDPAIQGSRPRARSPLATPDYDPRNPMDRYNQHERQPSDVRSVSSPPRNRPSRGNCKSCGDAIKGKSISSADGRLTGRYHKTCFVCTTCREPFSSAEFYVHNDRPYCELHYHKLNGSLCGTCGRGIEGQYLEDEERVKYHVGCFRCGDCGMSLSNGYFEVKGKAYCERDAWRRMQPAPRMGNGEQRGRSPGGLAPGGPGQGGRRPSNGQSGMRPPVGLPRGQRMAPGAGLAPPMPRMNKRMTRLGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y808</accession>
    <name>A0A1B7Y808_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156652.1">
        <property type="nucleotide sequence ID" value="XM_018304629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y808"/>
    <dbReference type="GeneID" id="28868736"/>
    <dbReference type="KEGG" id="chig:CH63R_09655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09655"/>
    <dbReference type="OrthoDB" id="4789692at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="225" mass="25047" checksum="A1652F7FB462FC34" modified="2016-11-02" version="1">MLTSPEIQVQLKKEFAGLIAPKRKKRHHSLQPVAAHQPFRPQPPARPCLVVNQAPARLRPLHLEDSQRPAPRKRAPLPPQHQPQPAVRQARHRPRRHQLSARSAPLSAATIISKPTSSSPTPPAAPTIYQARDEAYAECNKLDDIRALDRVAQAHHTWRPKTCFGAGPYTLADVARDFKKRSWSSSSGHATTDDSKAAMLTCTTTATLRKPPSRKRQCVRRATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8F5</accession>
    <name>A0A1B7Y8F5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hard surface induced protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156802.1">
        <property type="nucleotide sequence ID" value="XM_018302024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8F5"/>
    <dbReference type="GeneID" id="28866131"/>
    <dbReference type="KEGG" id="chig:CH63R_07049"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07049"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="42"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="350"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="645" mass="71123" checksum="DAF2047214836A85" modified="2016-11-02" version="1">MWEESTRGQDGQLDMPARSTKEREGGTDEKTSRGGAADKIRCLDGLRGVACLLVFNYHFLWPWTPAIMLGYGAMPPGSPEPYFERSSLPILCLLQRGRPMVAIFFAISGYVLCRHILRAIHERRLEAAYQGLASSVFRRVFRLYIPPTISMFLVALLAQMGAFRSEDDIYKGPDSRYINGTVTVAQLNVNGTRCVNGTRAVKGASGVADYLRLQTPAFLGNVTTNETSTLCLNATSQLFMPAMLYMLADDIEAKAKAANETRARGLNGTMINVTMEDTTTTTTTSHEGDKAKAKAEKPKPSYHDLLHLHMRPAAALSGDDDDDDANGRANATRSPTNFTWVQLGGSWEEHPFIHDNMTYALKNFTRAYVEWANPFNFGHYHTRYDPHTFTIPMELRGSMFIYLFLLATAALRAKWRFRVGALLSAYSLVLGRWDMATFMGGVLLSEADIRRADSNGGGAGGGGGGGGGLLPPATSSKKSRHRAGLGQSALGSRTTRWAALVVALYLLSYPDAGAEWTPGFVVLSSLVPRYYAPLSGWMFYQAAGALLLLPCVLHSPTLRGALEGRAAQYLGRVSFSFYLVHGPVLHSLGFWIMPRLFERLGRNTGFVVGWVVLLGVSLYLSDWWCRKVDVWSATVGRRVEKMMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8L1</accession>
    <name>A0A1B7Y8L1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156897.1">
        <property type="nucleotide sequence ID" value="XM_018302119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8L1"/>
    <dbReference type="GeneID" id="28866226"/>
    <dbReference type="KEGG" id="chig:CH63R_07144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07144"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="235" mass="25838" checksum="947107153B796305" modified="2016-11-02" version="1">MAADNEEHEGASIKELLIEACRRNNTDLFNEVIADIKDEDELSRLLNETTTVMGNHLYHEAASRDEIIDLLLDQPNFECDPVNRLEGDTPLHTAIRWINSEPPAQRDFGNALVEMMLEAGSNPRVKNKGGLTAPQLVDPRNPGLRDLIQKHEYATMNAGDFINVDSSSAAASHGKKKGAAPAVPNAAAPPVPTNAAPPVYNDDNSSDDDAEFSGSDDEERAEWDRRRKERATRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8S2</accession>
    <name>A0A1B7Y8S2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156885.1">
        <property type="nucleotide sequence ID" value="XM_018302107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8S2"/>
    <dbReference type="GeneID" id="28866214"/>
    <dbReference type="KEGG" id="chig:CH63R_07132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07132"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601426" evidence="9">
        <location>
            <begin position="21"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="141"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="596" mass="65451" checksum="8CA8C4E9CD275708" modified="2016-11-02" version="1">MNQLLCNIVLFLTFAVSAAAVIVLTFVPCYATICSEDYFDFETRLHLIIYYGLLAVLGIALLLRKYFPRVRTISGHHLLPGGPLVSKSVTVGGLLASVWIVGVTASTTVFWLPAQWDFWGQRADPLGWMSAKIQLTITGVTGHYADILLGLLIIPVSRNSLIGKGLSLHQSTLLFMHKMVAYLYSAAATAHGITYIIYASDSSSEGDEAKEEAFATGNPAMTLSESKQRSEWFTLTTYTGIAAILPVWIIVITSIPWIRRNHYNFFYYNHVLFGLVIFVAASIHASTDFYLLMPGLLLWLADWACRIFAGEAGGLSSKTSATLENAGNGWLRITLPPLRKLDDSYSRVIALEEKGRPSFQPLLYYHLQIPAISRLQNHAFTAAIPSSIDSGPVFLLQPTTGKSQRRLNKEWTWKLASLVSEPLSTKTINVRAEGPYGVGDNGFETASHLICIVGGTGITGACSLAHWWLERRPENTFFTLVWTVRDREASMIREWTDLQQTANSVPNLTTFTHVSSEIGRVVPSEHLNNALALAGGAVASSSGHAWVYSSGPTGLLDSVEKACIGAQKSIRVAKDEKGASSWAVQDIGWYVAKWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9F6</accession>
    <name>A0A1B7Y9F6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157239.1">
        <property type="nucleotide sequence ID" value="XM_018302461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9F6"/>
    <dbReference type="GeneID" id="28866568"/>
    <dbReference type="KEGG" id="chig:CH63R_07486"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07486"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="19900" checksum="B95B7852E7C41962" modified="2016-11-02" version="1">MTSLASYLLPDAFMDTSISSEQLYCSPVWTRVIRLPPHLRLQMPKSKRPVRTLQGALALQPFLSSHSAACYRAVYGAPGAGGVVQGTKYFEPSAPWPREALAARTNCCTGAFNWMIRESAREEENERRNFDSFRGWWSVYFPFFFCFLVSVLFLFYFILIHILILFFPPLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9P8</accession>
    <name>A0A1B7Y9P8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_07462</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157215.1">
        <property type="nucleotide sequence ID" value="XM_018302437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9P8"/>
    <dbReference type="GeneID" id="28866544"/>
    <dbReference type="KEGG" id="chig:CH63R_07462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07462"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
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        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
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        <property type="entry name" value="Trans_IPPS_bact-type"/>
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        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
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        <property type="entry name" value="CarR_dom_SF"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR08697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="590" mass="65377" checksum="19F19C40F31FD581" modified="2016-11-02" version="1">MGYDYALVHVKYTIPLAALLTVLSYPVFTRLDVVRTLFIVTIAFVATIPWDSYLIRTNIWTYPPDAVLGPTLVDIPIEELFFFVIQTYITAQLYIILNKPVLHAQHLNSPATLPQWIKGGKVVGQLALFSSVILGAWLIAKEGEGTYLGLILVWACSFALFTWTITAHFILALPLACTALPILLPTVYLWVVDEMALGRGTWAIESGTKLELRLFGSLEIEEASFFLVTNMLIVFGLAAFDKAVAVCDAFPDKFDKPADALSMSLLRARVFPSSKYDMQRILGIRQAVARLAKKSRSFHLASSVFPGRLRIDLTLLSFVSYSYCRLADDLVDDAESSEEAAAWISKLDRHLSLLYKDPDAVSAPLAAKYAAENFPASALSALDMLPASLLPREPLAELLKGFEMDLSFDSSTFPITDPEDLELYAARVASTVGQACLELVFRHCHHGLPDYMQAYLRNTARQMGLALQFVNIARDVAVDAKIGRVYLPTMWLKEEGLTSEDVLSNPTSEGVEKVRRRILAKAFDHYAEARDSMKWIPSEARGPMVVAVESYMEIGRVLMRNGGAAADGSGRATVPKSRRIWVAWSTLMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAM5</accession>
    <name>A0A1B7YAM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157670.1">
        <property type="nucleotide sequence ID" value="XM_018302892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAM5"/>
    <dbReference type="GeneID" id="28866999"/>
    <dbReference type="KEGG" id="chig:CH63R_07918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07918"/>
    <dbReference type="OrthoDB" id="5090168at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601480" evidence="3">
        <location>
            <begin position="25"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="327" mass="36219" checksum="C93394F26FF846E5" modified="2016-11-02" version="1">MEKPSGRPLLTAALLLSTLPSALAQNARVKVTLDETFRTVAPPNDAFAHNADHVRVASTVLLGLILTFVLLSLRESKRWSSTVPTALTLGAATCILPEAVDNYLANCYWAQSHDPSQLMFTFLGREFDVYVGIIWWSFGAVLGCTIFGALMRGVTTKTLWVLLGLAALFDLVLEECLLNYGGLYLYYGHQPLVLVSKFPWWWGFCNVSAIFLGIASTYRYREWFNGWRSIFVLPILPFCYIAGWSLAAMPTVYAVHADYSFFITQLCGLLTCCLALVQTGVMMDVLLERDPLKLDQSGRSPRLGKGTSSSTRSASKTKALGQIWEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAP4</accession>
    <name>A0A1B7YAP4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157690.1">
        <property type="nucleotide sequence ID" value="XM_018302912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAP4"/>
    <dbReference type="GeneID" id="28867019"/>
    <dbReference type="KEGG" id="chig:CH63R_07938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07938"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601485" evidence="1">
        <location>
            <begin position="31"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="333" mass="37538" checksum="F07ECD986D344C10" modified="2016-11-02" version="1">MTVKTIPSFGSRSLCVVFFSLLAHLIPVVASPKPAVNPTHVAPDPVLTKRVKLEIPDFGKGYDGRVKKGEWLNSLFSLNDEDAKKWASPYPSPDELFDWGWTPYVQAPWIPLQEGQKVRKPEFGNKLDVAFKDPEFPVDKEKLALYRFVHNEEFEYKDGRKGEPTEARYYNVAGPHDGAFIFDSNWSPTYQKKEDGVGDVPDLDTLSDLAYFQWRDSCQAVGVEFGSLKVIFRANIYFAPTFDTVIETMRQAKYPQVPGWDGRVTFSMDSPEGRAILGSAHGASTAWFLIQHREEMGAKRIKEVVVWGASGAFDLETDMKVANLNLRFTVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD92</accession>
    <name>A0A1B7YD92_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158580.1">
        <property type="nucleotide sequence ID" value="XM_018300730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD92"/>
    <dbReference type="GeneID" id="28864837"/>
    <dbReference type="KEGG" id="chig:CH63R_05755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05755"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="132" mass="14137" checksum="CB786A2FF411E3C5" modified="2016-11-02" version="1">MFIDEKDTSTAIPEITNDTSASLPPLAELAASPDAAAGLYIHSRTGETVQVKIPRDCIAFQTGEALERITGGRFKAVPHFVRGVRASVSDGRVARNTLAVFTQPNLGEEVDIEQHITFGEFARGIVAKNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE60</accession>
    <name>A0A1B7YE60_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158884.1">
        <property type="nucleotide sequence ID" value="XM_018301034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE60"/>
    <dbReference type="GeneID" id="28865141"/>
    <dbReference type="KEGG" id="chig:CH63R_06059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06059"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="99" mass="10955" checksum="9392116A29BD1F1E" modified="2016-11-02" version="1">MLPTHLLSPPISTPASCADRPPHPRQRGAVDSSARPRFGVRINGDDGTENRVSAPPRLSALVRIRLLREGTKVWDDHLSVRQGEAVSERQVSRDQAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEX5</accession>
    <name>A0A1B7YEX5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor aceii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159174.1">
        <property type="nucleotide sequence ID" value="XM_018301324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEX5"/>
    <dbReference type="GeneID" id="28865431"/>
    <dbReference type="KEGG" id="chig:CH63R_06349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06349"/>
    <dbReference type="OrthoDB" id="2574141at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="229" mass="25403" checksum="FEFD11C158BF590B" modified="2016-11-02" version="1">MSGLPPVAKFHVSGANMKERCLEVSKHYSLKNSLEVMLNQTQNLVDTYPETVRLALEHLPNDECCQADCIHTYESHLDLGEDPFKTAAHLATKVDYPLLKLLLSCHYQCADMMELVLCHTQVCFKSLAAAKQQGDDPHQFEIPELRMGSFTPSPRFSPSIVTAILIDLQSSLAGCVLKLTTALKKFDQGLGKEGRIILLECDLLSERAHSIVESLKKLRGPLTKAGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH69</accession>
    <name>A0A1B7YH69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PLU-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_03702</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159923.1">
        <property type="nucleotide sequence ID" value="XM_018298677.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862784"/>
    <dbReference type="KEGG" id="chig:CH63R_03702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03702"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000010">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000014">
        <property type="entry name" value="PHD transcription factor (Rum1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="12">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="475"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="617"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="423"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1549"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1672"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1565"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1675"/>
            <end position="1694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1734" mass="194451" checksum="4569F1AE917F6088" modified="2016-11-02" version="1">MVPAPTTGGSAAANGTGSANASSRASPAVGAPNTASAKSKAAQGNSNGPRPTNSQVPLSSMRSAPLDLTSVERRGQATAVKEPVKKKTRPHGLEEAPTYYPTEEEWKDPMEYIKKVSPEAKKFGLCKIVPPSSWNPDFAIDTEVFHFRTRKQELNSVEGSGLLQYQSLDGSSMLTNLGTRANMSYLDALAKFHRQQGNNLHRLPYVDKKPLDLYRLKKAVEARGGFDKVCKLKKWAEIGRDLGYSGKIMSSLSTSLKNSYQRWLCPYEEYLRLAKPGVHQQLELENGGPYTPSPAVTPMKRSNVNTPSSARADSPARSASDALQASINGLKKEGDRDTPMTDAPPTPAPVTSGFRAINTGGFTAVNSGFKSVNRPTPQDDVTSTPPSKSFSPVNSAKNTPDYRPSNLGPAALKRQISCESLDLAKKDTATDKDDGDTGSSSRRSKQTVPTVAGSHMSLFRPSVPRIPRDEASNPGEKCEQCGKAEETGPLVVCESCDQAYHCTCLDPPLKHKPESEWNCPRCLVGDGQYGFEEGGLYSLKQFQQKAADFKQGYFEKKMPFDPTLNCHRPVTEEDVETEFWRLVADIEETVEVEYGADIHCTTHGSGFPTVERHPNNPYSTDPWNLNLLPLHPDSLFRHIKSDISGMTVPWVYVGMIFSTFCWHNEDHYAYSANYQHFGATKTWYGIPGEDAEKFEAAMREAVPELFETQPDLLFQLVTLLTPEQLKKAGVRVSALDQRAGQFVITFPQAYHAGFNHGFNFNEAVNFAPCDWEPFGLSGVERLQVFRRQPCFSHDELLWTATEGTTNNGLTIQTAKWLAPALDRIKKREVVDRADFVAKHLEPQWHDCGLAGKDGASCPLTFEIDDTDVPEEEYQCSYCKAFTYLSRFKCLKSGKILCLAHAGHQPCCDMPERQRIHGEGHAVIYRQSEEDIDAIYAKVLEKARTPEAWEEKYEKLLEEEATPSLKTLRNLLHEGEKIPHDLPSLPLLREFVERCNEWVEEATNYTIRKQQNRRKSEKSILNRKNSLDQKERDARNVSNVYRLLNEAEQIGFDCPEITQLRERAEAIEAFQKNAAKALEQIHLAELSEIEDLLEEGRTFNVDMPEVDRLSRVLEQLRWNEKARNNRGTHMSLNEVRELIEEGKHLDIPPYNDHLSFYIDQMNLGQQWEKKARELIVAEIVHYPQLEALSMQVAANFLPVSADTLAAVDQILYKQREAHRQIVDLTERSRNPDIRKRPKYAEVAEIMRRLDDLNSKPNGTLDLEREQKRHEDWMREGKKLFGKTNAPLHILKSHMDYVFERNQDCFDIVNDKPRMPAEPASREASPDQKVHRWEDPRFREVFCICRKVEAGMMIEYHGKCLKIARGKVKDEDKYTCPICDWRVKIPRDAARPKLEELITWSEKIPSLPFQPEEEEVLTKIIDNAQDFRNHIAGYCNPVVSTESEADTQRFYLRKIEGAEILLAYETNFFRQELHKWCPVAPNAPPVLEVSKSTRKPRPTKLQKLLAQFGVDDPEDLPENMKAKAASLKRKAQNAEAAAAAAAAAAAASATGATVPPGMPGHGRKSEQSSATPPSTSHGNRRSIGSNHDAMDIDSGPTLHPGLFLSNGAPGPQLVVGNSSLSLEERLLQGQEDGLNLHTEAGKSKALEILRRTEVGRKRAVEMFGPDVFKGDVGMLNGRDDVPRSQEEERAVNKMFDDLTNQDDDDGKRKQESFDGPITAESLESERNGMDALLDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH83</accession>
    <name>A0A1B7YH83_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159946.1">
        <property type="nucleotide sequence ID" value="XM_018298700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH83"/>
    <dbReference type="GeneID" id="28862807"/>
    <dbReference type="KEGG" id="chig:CH63R_03725"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03725"/>
    <dbReference type="OrthoDB" id="5382128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601657" evidence="1">
        <location>
            <begin position="20"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="675" mass="76764" checksum="62A8C062C86DD0CE" modified="2016-11-02" version="1">MRLSATLAIAPLGARLAQAALDLDAITEKYFSNDAPWYKNRVPLFESSDTQITDVYYYRWNLFRTHQRDIGSKYGFISTEFIDNVGWQTQPWASNNCAAIFHLSEGRWCRDPRFKRDYAAFMYSSDSNPRQFSESMADGVWRNYLVDGDPELAFSLLDDMQRVYNLWVGDHFDESKGLFWVEPIADATEYTISSIDASGGYDGFFGGNAFRPTINTYQYANARAIAKIASLKGGLDSVVEEYNSRAEALKETLQRDLWNSTFEHFVDRYFVDNENVTYWDFIRGRELAGLVPWAHDLPDDDAKFGEAWKHALNSDELGGPFGLRTVEPSYEHYMRVWRYEGTQTECHWNGPSWPYQTTQVLTSLANVLDHYPNSSSLVTVGDYTRLLRQYAQQHYNKHYGNILDIEENYDPDTGEPIVGLGRSHHYFHSGYVDLILSGFVGVRPREDDVLEVNPLADPAAISYFRAERILYHGREVAVQWDATGEHYGVAGLRIEVDGKVVASSDKLERLTAEVTRAPVSVVRPLAQSIQLQATEPLPIINASVPNYNVDRLHDVFDGRVWFWTQDTIANGFDTPENSNAEEWVSIEFGSAVDAARAEVAFFANEERGFDVPASYKLQVLSGEWTDVPDATYDKPLANGITNFKWTAVSTESLRILVTPQEGKRVRLVELKVFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHL2</accession>
    <name>A0A1B7YHL2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160158.1">
        <property type="nucleotide sequence ID" value="XM_018298912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHL2"/>
    <dbReference type="GeneID" id="28863019"/>
    <dbReference type="KEGG" id="chig:CH63R_03937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03937"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="670"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125073" checksum="95DAE4677E41ABDE" modified="2016-11-02" version="1">MASHSRRRRREDFQIAVICALPLEYDAVVFACDEIWEEDRVELRNASGDCNTYKTGRIGGHNVVLLLLPGMGKVNAATAAASLRSSYTEIKLAILCGICGGVPGVKTSNEVFLGDVVISKSIVQYDLGRKYPNRFAPKDTVEDTLGRPSQGVRSLVATFQTLHGRSDLQRRASQVLEQIQQRAADEGHQNLYRRPAEADRLFEPDYLHRHRNSPSCGCSESEACEDALTTSCEMLQCDHSRIMPRMRPMTQAFEKQTLNDIATQEVRVLVGRLGSADTVLKAGLDRDRIAKEHDLLAFEMEGAGIWDVIPCVVVKAVCDYADSHKNKKWQHFAAATAASATKALLEHYTHMDRHSAPNSWCVSSCSVQRKPGLRWAIRSPQSDQTAFWAHGATRKPVCNTTLKSCALWAWGYRVLWAASLEPRRRLTSCRKTQIALAYTFWLHHAHPDVSVFWVHASNAERFRQAYSSIAQECSIPGHDDPKADILLLVKTWLERGIRGRWLMVIDNADDTHPFFPPHSLAGSINTNPTTDTQGGLGRYIPECGHGSIIITSRNKQTASRFVRGNSLLEVRAMSESETGQLLHTMLDDEFSAEEASVLSAQLEHLPLAIAQAAAFIQENSISIAKYIQLLEESDENLVEQLSEPFEAVGRDSETPHALTATWIVSFNQIQQQDALASELLSFACLLDRQGIPEEFIVSFCNQRNTEVQQISASKIAKALGALKAFSLVSEATDNTIDMHRLVQLVTRKWLEIHGRLAGCVEQALDIVSDLYPDGDHESRQVCQDYLPHANAVLQHKGTGSCDERLAKATLLLHMAGYFLYRGQWTQAEQGAAQSVKLRDEILGKQHPETLTSMNNLALIYSHQGRHKEAEELEVQVLEARKRVLGDEHPGTLLSMINLASTYLHQGRLEEAEELEVQVLEARKRVLGDEHPNTLSSMNNLASTYWNQGRLEEAEELEVQVLEAMKRVLGDEHPSTLISMINLASTYLYQGRLEEAEELEVQVLEAMKRVLGDEHPSTLISMVNLALTYWNQGRLKEAEELEVQVLEARKRVLGDEHPSTLLSMVNLALTYWNQGRLKEAIQLMRDCVRLRQRCLGEDHPDTISSISTLKKWEEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI84</accession>
    <name>A0A1B7YI84_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">XPG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160378.1">
        <property type="nucleotide sequence ID" value="XM_018299132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI84"/>
    <dbReference type="GeneID" id="28863239"/>
    <dbReference type="KEGG" id="chig:CH63R_04157"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04157"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="487"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="735" mass="82257" checksum="35DDC35D05186E07" modified="2016-11-02" version="1">MTGLVEDAWINGQAASHDVSELEDCAIAIDATYYLQLFLDTPPFHEPLLPALGGMTGIEHHLRADIDQWKAHKIVPFFIFDGQSVTGQEEVAVQRGKAANQKTDTAWNLYFNSEAQQAVDSFGANSGAYRIQSLYPLLKSILKDNDLHFLVPPYNASAQLAYFDMIDSDQCAAVMGSQELLLYPIKDTLIRTIDWEAKTVTSLSKKNLLRSLNISEGMLGDALLMTGTSFLPPFPPLQDTSLNPRQPFTINDAVNLLRASEKSVQSACSSYGDILKKQDANWLDKYRQAKMAVNHFIYIAEDGEIKVNDFDHITRDNHEYLGLQLPGELFHYLNTGLIGSRVLDYITHSRIVVTPTLDGVASEQYKKLVTSQIVPLKEQSIALLIPRLHRGLQHNAITMKVWFDDSFSYQINKSLQPSPSQRAATWDVKESSFKTVADDVADPPGSIAFEILALLFPDFVKGTFPKDKKRIGGIDSIENITAVAIWRFLHLRGYVDDSHTLTNWGNAVASAIWAMKDSLKELQIPEGLNIFEAILSAFELIRHDVLNARHRHEELNGAPMTGSDEDKASILLISRCASLLKLRHESNGYTGPLNKNLLLFRSLSTAVREADRDLVEAIVASMFLYAQSKRDRTDYLQISQALPFLHNPDIALGIAVKTLMDELPASESVEKRQARINDFPGKFFPYATNFKDDVQLAFAFFEAIHKGVQTLNKEVSAADKAVWSTASNYLDQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIS7</accession>
    <name>A0A1B7YIS7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_04279</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160500.1">
        <property type="nucleotide sequence ID" value="XM_018299254.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28863361"/>
    <dbReference type="KEGG" id="chig:CH63R_04279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04279"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="207"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="533"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="604"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1412"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="654"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="539"/>
            <end position="547"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1551" mass="174603" checksum="F20E9A1709B6BD81" modified="2016-11-02" version="1">MLTFKQKSDPSFDVRIRASSDEDLAITLGVVMTATYPKSPPLLTLKSTGDLREVTLFKLQKFIETQPKIFATEEQEMMDRIVEGLRDILEDAAQAKAKGLELPSLEEERASHEALLAKLAQEQREEEKRKKEEENKEEERVLGGLLQVELKRQKDKAKETRKKNRPNGLPSLNTMDGFNGPESGRIIFDRPCNTTDKTGNIISFQAVFGKSEIAKGSVSTVFSVWPVVDSGQDCPTLALKEAVLRTTAKEDVSVFKKQIQSLESQLEALKLVRHRNLLEVLDFRVEREKSNMAKALASLWTVNVLTPSAEKGSLAELLDLAGQLDTSKVRAWTRDLLDALNFLHNKSMVHQDIHAGNVLLFREQTGEVVPKLADAGYQRELHNIKSKSHAPLGLSSAKSAYWLPPETAALSKPHYTQKTDMWEFGIVFLQMIFGLDVPQKYHSPSSVSDSMSLSRPLQELVTRFFKADPKKRPRAFELGSSEFLATDAPVIVEDSLAITSNYHSLNTLSPIPPRLRRESTNRTLTSSRYREDFDEEGRLGKGGFGEVVKARKKLDGQIYAIKKVSQRSQASLTEILKEVRLLSQLSHPAVVRYYNTWVEEIPDQSDAEGDTSTEDLNTEDSRDTISQGPAIHFTTSTGGLDFMSSSGYPQVEFGYDDSDAEDDSGSEEEDEDEDDSEDESDSDSDNSSQAVGRAPKGKEILRRTQSHRSSRTVLYISMEYCEKRTLRDLITRKLYQNTPEIWRLFRQILEGLAHIHGLSIVHRDLKPENIFIAHSSDGTDNVKIGDFGLATSGQFAVDKALPNAMESDDITRSIGTTSYAAPEVRSGSSGMYSSKVDMYSLGIIFFEMCYPPMLGMQRAEVLEKLRRPSPILPPDFKPAERVQTEIVLSLVTHNPKERPSSAELLQSGKLPVQMESETIRRTLAGLADPSSPYYKKMLSTLFSRPLEQAKDYAWDMHESSPSQSDLLNQSIVKETLISIFRRHGALECQRTCLYPRSAHYAENVVRLLDSNGTVLQLPFDLTMGHARMLAKASAAPGVQRTFTFGNIFRDKGDTGQPYMLGEVDFDIVTTNTLDLALKEAEVLKVLDEIIATFPSLSSSQMCFHLGHSDLLQLIFDYCRVEHGSRRAVADVLSKLNIHHWTWQKIRAQLRSPMIGLSATSVDELQRFDFRDTPSKAFSKLKTLFEGTDMYQRASSTLAHLREVSEYAKRLGVASKIYVTPLNSLKESFYTGGILFSCLYDKKVKDVFAAGGRYDSLIRENRPKIGNNYEERHAVGFNLSWEKLSRSPKSGGRAFLKKSEEESHDIFDNAKRCDALVASFDAAVLRSTGIEILQMLWSHNISAELAKDARSPEDLLSRNRDEGYSWIIVIKQDAILKVKTMDKKDTPDVDIPMAQLLSWLRAEIRERDSKSVVKLRGSTQQSETGAAAETHHEQDVRVLTAQTRSKKFNRRTVVEQAQVSAGSLVHSFLDGPILAVETTDQVMDLIRDTCLSDGESWRKVEHSVTTAEKKYVREIHDMLLNWKWTWEKKNASRHSFLYNFRTGNCIYYDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJW2</accession>
    <name>A0A1B7YJW2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_04616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160837.1">
        <property type="nucleotide sequence ID" value="XM_018299591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJW2"/>
    <dbReference type="GeneID" id="28863698"/>
    <dbReference type="KEGG" id="chig:CH63R_04616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04616"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115303" checksum="83B5BD6D4FC8264D" modified="2016-11-02" version="1">MTSVLPAHPTNFKVSISLSPTSPATMAPKREPRESPQHFIKQEHDAGRGRLREVSEDKDIDIMDDDGDDGKAGSSNSEGGPARKRRRSRKGLDKKFECPQDGCGKSYSRAEHLYRHQLNHTPKQIYECDFPDCSRTFVRLDLCNRHRDRHTAKGSALSRKDSMISHLSPTTDRPPFPVPGSTSPEISRPGIGFANVRQPQIHYETPKDTSGSPFAQATNTPPGYPVGSHPVGMDGYMHHDNGFAGVQAHRQPQQPPSGARPTVQSNGAYMSPVPTQHGYHSQPHNTPQSAAYTTQQNFPPFNLPPSEFSNGASNVSREGQTYAPTTSAEYNEQSHPQQSGEMMLLDQMSMPGTIPVFGSDSILSKSPYVTIPEDFVAYLFNTQQGEGSPIGHIVAPGYVNNYGEVQNSYSVPYVGTEGVPMGYFPSGPHQVMAVNNLLDQNLPEATISEEKSQEIYEFINQRFHENDQAPALRQRDSILEGDRSDGDHMLSKRMMQAYIGSYWVHFSDQIPILHKPTFSPDRTPNLLLLAMMTIGAACLDKTHGQKVTKAGAQLSNFLAWHLRWEIFMDPNFRPPAKLWLFQTLLLLELYEKMYSTRELHERAHIHHATTITLMRRGRSLIGKSSLDSPPNPRDDKTNGSRHSSTSGVAHTPDEWWNHWITNESTRRAAFAAFVIDSIHATMFGHSTVMVTHEMRLPLPCDEALWKATSGAEVGRIESNLLSNGVKPISFLEGLKRTLSGQGVQTNPFGRMVLMAGLLSVSWHMNQRDLQVNVLGGGVSQALGGRDKWRGTLTRAFDAWKDDFDQSLTGAKDSSDPYRYDSAKKNDANMVFESRMVLHHLAHMAMHVDIVDCQIFARAKRLLGRAIGQQDLNSAQRRMRDLWAPSAKARDATFYALKFLSSVLMPDGGHSPQSNGYKYDEPYTARDDVLLNRPWVLYFAALVVWCYGFALEGPCPGNPVPVTKQEQVRQMREYLMKYGGATSPDDLKMMKGVNTNTALLLVLKDSFGTTRWELLHEGANLLNNCLQLNTGTSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL60</accession>
    <name>A0A1B7YL60_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Poly polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161293.1">
        <property type="nucleotide sequence ID" value="XM_018300047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL60"/>
    <dbReference type="GeneID" id="28864154"/>
    <dbReference type="KEGG" id="chig:CH63R_05072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05072"/>
    <dbReference type="OrthoDB" id="3262926at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="279" mass="30878" checksum="02FFAEDD15A14521" modified="2016-11-02" version="1">MDLLDELDTIARLAATHSEDTEPTSDDSLFGYTYFEAAQKMQEHRSHFARWQASENHWEMVRADQEAQGHDKESYEYSYTLSPIQSPAAAASQTKKKARPATYLLKLEGPFSDPETVKRAGGVSAAPPSRLIGIDDTGAAASFCKVGEATKKSLLTQLSRIGSSFQPTFYPVWYFFYETLADPAVLKSRLGVEPVYHPAKTRGGVLTTWGGKYRALVDGPAYGTGPWRAMPFLSPTRTRRMRSGATRQTTTKVVRCVIDMGEGEEVRGLTFRFIGDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLN2</accession>
    <name>A0A1B7YLN2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161325.1">
        <property type="nucleotide sequence ID" value="XM_018300079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLN2"/>
    <dbReference type="GeneID" id="28864186"/>
    <dbReference type="KEGG" id="chig:CH63R_05104"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05104"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="120"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="290" mass="32993" checksum="8A8577C73DB925DA" modified="2016-11-02" version="1">MRSKKHDANAVEAIPHLDTETYHHLIPRSSAQSRLSSGDGFYTSNALHTFEKGLQEDRPSGNVAVLMETNTSAVPNLVPIVLHFASVLGPNWPIVLVTLESTWVVPESPAFRRLMDANQIRITYLPATTNISDHHSVSVFLTEPWFWEQFVSSHRMLIFQVDSILCSKAPMTMEDFLEWDLVGAPITVYGIGYNGGLSLRNPRLMLDIVNDPSVSLGPRDYEDQWFYARAQERGAHLPNTEQALKFAVETTYYKTPLGYHRPKPFQGEHWDEITEWCPEVGLLWGHRFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLV3</accession>
    <name>A0A1B7YLV3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_05305</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161526.1">
        <property type="nucleotide sequence ID" value="XM_018300280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28864387"/>
    <dbReference type="KEGG" id="chig:CH63R_05305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05305"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1252"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="18">
        <location>
            <begin position="159"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="396"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1412"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1461" mass="163063" checksum="61D2AAA7ECA21D43" modified="2016-11-02" version="1">MYLPVQVPIDCAPVRHREVHFGQITTLPFRHPSGFFSFASPPPPVVFSAASNAKEKRAKERETPHQQPSSFCHGSLGLSANSISFGFAFLHQHRRKQQTIDAKGDLDQTITHPPILSPPPCPVARAVVPSARARPPRSSIMAPLVDNPQIRVAELWKPLPTYFHAYVWPFAILWPIFLRYYLTPELYEKHIASEEWTFVWIGSIVTLQSLVWLSTHWSVNLQALFTATRAKSIDEAELVKVIPVANAGSADICNIVRDKVGGKINTSFLFQKRRFIYYPEDKSFRTLAYDIDAEPKPKIGRYQQSRGITTQDELTRIEEHYGPNAFDIPVPTFTELFKEHAVAPFFVFQIFCVGLWMLDEYWYYSLFTLFMLVAFESTVVWQRQRTLNEFRGMSIKPYDVYVYRLGKWTEIMSDKLLPGDLVSVGRTKEDSGVACDMLLVEGTAIVNEAMLSGESTPLLKDSVQLRPADAHLEPEGLDKNAFLWGGTKVLQITHGNPDEEKPKLASGVPPPPDNGAMAIVQKTGFETSQGSLVRTMIYSTERVSANNVEALLFILFLLIFAIAASWYVWDEGVKKDRKRSKLLLDCVLIVTSVVPPELPMELSLAVNTSLAALAKYAIFCTEPFRIPFAGRIDIACFDKTGTLTGEDLVVEGIAGLGLGQTAGADTPRETDGAHSQMTPVDQIRLDTTLVLATAHALVKLDEGEVVGDPMEKATLTSLGWTLGRNDTLASKPATAAATGVSGTVQIKRRFQFSSALKRQSAVATVNGADKLGNRIRGTFVGVKGAPETIMKRLSTVPADYEETYKYFTRRGSRVLALAYKQLTVDNELGGSKINDLKRENVEAGLTFAGFLVLSCPLKDDAKEAVQMLNESSHRVVMITGDNPLTAVYVARDVEIVDRDVLILDAPEDNEGGDKLVWRSVDEKIIIPVDATKPLDPKIIESNDLCVTGYALAKFRDQVGWQQILRHTWVYARVSPKQKEDILVGLRDMGYYTLMAGDGTNDVGALKQAHIGIALLNGTQDDLTRIAEHSRNTKMKEIYQKQVDLMKRFNQPAPPVPVMIAHLYPPGTSNPHFNKAVEREALRKKITPEEWLKANGVSAIETVTSPGAQQLLNNNDPKAARQAKAAANAASFADKMTSSMMENELGDDEPPTLKLGDASVAAPFTSKLRNVIAVPNIIRQGRCTLVATIQTYKILALNCLISAYSLSVLYLEGIKFGDGQYTISGILMSVCFLSISRARVVEGLSKERPQPNIFNFYIIGSILGQFAVHVVTLIYIARFCDRLEPRSGDVDLEAEFAPSLLNSAVYLLQLIQQISTFAINYQGRPFREGLRENKGMFYGIVGVSALAFSCSMEFIPEINEQMKLVPFSDEFKTTMTGIMVIDYAACWVIEVVLKHLFSDYRPRDIAARRPEQLERERIRKEAVQKKKEEEEDQKRLEKVAEFERKVEERRQQLEAWRQGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMC5</accession>
    <name>A0A1B7YMC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161575.1">
        <property type="nucleotide sequence ID" value="XM_018296759.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28860866"/>
    <dbReference type="KEGG" id="chig:CH63R_01784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01784"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1417" mass="160080" checksum="F5B7222CD06E140A" modified="2016-11-02" version="1">MATRPTAETPSREDQLMELTLQLRNEENAKKYAQFHGDSLISNKTPDKVGLLEDLTAALAPSNWGALGDIVGSFLSGKPVDEAGLAQVSGSLSNDSTNRERLINDQVRKKYDKMLHPPLTYLGDAFQYRTADGSFNSALNPHLGQAGGPYAKTVPSKTAPLGALPDPEVLFDRLMAREAGGRQSQSGLSSMLLYHATIIIHDIFRTNDDDKNISDSSSYLDLSPLYGYNESMVRKVRDDKYKLGLLKPDTFAEDRLLRQPPGVCIMLVMYNRYHNYAARQLLRINENGRFSLPKMYSGTRLVALIKEHLPDRDDQGVKMPLDSKVNLLCNQYEDLWGKVRAARPPDAPDAPKKQDSETPEQTAVREAAEKKRKAALDLITAFESELLYTKFADVERQLKQKLKEKGNKLERESPALLKSFEKKCKDFKMAWQAAWDKQDDDLFNTARLITQGMYVNISIHDYLRTLMGFHQFDTNFTLDPRKDFDQKKTTRGLGNQVTVEFNLLYRFHCAISLRDEKYTEDYMKAKLGIEHPEHLSLPEFLKVMSYEKQKGTKPVEPWQVTFGIPDVPAPKTTPGSKDGHSTERSRNNSDSGISLGSTGVDVDITKAKAPAVATPSVANSKHFERNEITNLFDDEQMLNELTAAMDEPLSNFGPRNVPKCLKPVEMMGIMQARKWEVGTLNDFRSFFELPVHTTFESVSANPDIQNALRDLYESPDKIELYPGIFCEGDAKMSLDPGPAESSPALWAAIFSDAITLVRSDRFYTVDWNTQSLTAWGMKEVTPDNDVCKSSVFHRLTQRAFPGWLPRDSLRWFNPFYTAKQNAIYAEQQGYASQFKDTAKIELMPYFDRAKAAARIVACPPEKPQKPCYLDNFEDIKVVLKDQSDHFTNPVFSYKSNLPRALREVLDRETARPIKFDPNILKKHVKSVEKELKTYLSELMTSIIKRESVSITKAEFQIDATRDFAIPVVTRYMAAFLGFSHKLREVPATCTVSDKRTQTAAHPGTYTENEIYQHITNCQVFLAYNTDETKWMARRTAFQKSVEKLIELARQGTIWEAKQLFGLSNMLIGKEETNPMHQMGVFVAKQVLKHEPDQTRAAAILLLISLDFTYNAVVSFTATLDGFMEDLYQVANGDNMEAEPKWLALQRAALVDEDNVVEKMVLDMARAKVNLPIVRKVLKKGQFKFVGVPYKGKSTTLKEGQHVVLDLAPATASAVEAQDTGRLKFLTLQLSIADKYAVFSPRDFIPLSQAQMIKFIALTRNTRRGPAAQGELKRVHLEATAEGYANYMAPERVEWIKEQVDKLEDQKEASRIFNDKIFVAGFDTFLTPSWDEYVPFPMTWKIRFDGFGKSDYIDQECKNVKYGQVRTVGKGLPDFCPPWYQPKGPSSTGGTFAMVELPQAVVVVVAARLGVKRGLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YME8</accession>
    <name>A0A1B7YME8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">CH63R_01939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161730.1">
        <property type="nucleotide sequence ID" value="XM_018296914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YME8"/>
    <dbReference type="GeneID" id="28861021"/>
    <dbReference type="KEGG" id="chig:CH63R_01939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01939"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="96" mass="10854" checksum="0B39BFAA2930D41C" modified="2016-11-02" version="1">MADVGEDTTHVQEPLDLVKLLLDEVVFVKLRGDRELKGRLHAYDSHCNLVLGEVEETIYVVDEDEEDEDVKTISRKSEMLFVRGDSVVLISPHTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMM2</accession>
    <name>A0A1B7YMM2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161786.1">
        <property type="nucleotide sequence ID" value="XM_018296970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMM2"/>
    <dbReference type="GeneID" id="28861077"/>
    <dbReference type="KEGG" id="chig:CH63R_01995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01995"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="224" mass="23249" checksum="0C2E5CA281563209" modified="2016-11-02" version="1">MTPVKALPLSSVLGSVLTTSAHPRLENEDFTDTSTTHQSSTPKPTPTPAPEPTPEPAPEPAPEPTPEPAPADGVSVGGMTGGGSGRMQKKGGTKRAQAEAGQSDRCEHDLVSPVHVRLSSYGAASVKRSRLRKAAPPPANGINGDGRASKRASDCPSGRENDTGEGTGGDVPGKYLALPPWERRRLEQPQEVCPQNQPLSANSPPALLSSSSSSVSAPASRRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMY9</accession>
    <name>A0A1B7YMY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_02161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161952.1">
        <property type="nucleotide sequence ID" value="XM_018297136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMY9"/>
    <dbReference type="GeneID" id="28861243"/>
    <dbReference type="KEGG" id="chig:CH63R_02161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02161"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601800" evidence="10">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="215"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR13435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="302" mass="33235" checksum="9C072A3C37A69546" modified="2016-11-02" version="1">MKAVMLGLASLGLASAVPGQQQQQQRPGPIRRGCQVPDDGVIPDVAAQLAGKTARRQAYPSNFTVDVNFHLASTEAEADLITDAIVDAQWTVLHDAFARYDINLRLNSTERVVDNRTGSAFLVYEGPEAGWVNYQAEYDAYLKATRRGGYDALNLYFFSSYSPGATGYCQFPTVIADPDSLTFYRDSCQLSAMTMPGFTVEQGGFEDWNLGHLAVHEAGHWFGLNHTFAGGCSDNPGDFVADTPAQRWEVYGCPADSDTCPDQPGLDPIHNFMGYTADSCTNEFTPGQKDRMFSTFFGWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YND3</accession>
    <name>A0A1B7YND3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucose 6-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_02168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161959.1">
        <property type="nucleotide sequence ID" value="XM_018297143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YND3"/>
    <dbReference type="GeneID" id="28861250"/>
    <dbReference type="KEGG" id="chig:CH63R_02168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02168"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF2">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase N-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="4">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="50959" checksum="A82AF00128E9D2AC" modified="2016-11-02" version="1">MKAAFDKPFSHSRSLSVPAPATPPPEGLGLNLLGFDTFKANLELPRTPITPPPEYQEHSFSHNNDKVADLSPIVSPDDHPLVAVIGVGYVGTHLVDSFSAHYDVLGYDVSEKRIREVRAELPGDRIRFTTCKTDLHEATHFLISVPTLLKADKSIDTSYLRSAIATVAQHARPGSTVVIESSVAVGMTRDLLGPVAVSRGFYAGMSPERVDPGRVEPPCHAIPKIVSGLDDRVPGSLASVMRLYNRVFDRLVPVSRTEVAEMMKLYENCQRMMCIAFANEMADACVPHGIDPYEVAAAAASKPFGYMPFSPSLGVGGHCIPVNPYYLLSNSAFPLLEAAAEKMAARPAVIARRAIDSLTRVAKAGAAAAAPLVRPRLLVVGVGFKAGQSVLSNSPGVELVRALAQSGEVDVMFADPLVKQSAVPAAPRLADEKWSRETLETFDMIIVSFRQHGLDFGVLEELRGVKVEMWCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPU5</accession>
    <name>A0A1B7YPU5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_02700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162491.1">
        <property type="nucleotide sequence ID" value="XM_018297675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPU5"/>
    <dbReference type="GeneID" id="28861782"/>
    <dbReference type="KEGG" id="chig:CH63R_02700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02700"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="505" mass="55516" checksum="1B941294D18E3CEC" modified="2016-11-02" version="1">MVFTRASATLARPVIRAARSSAAALPRRTLCASAPRMAASASLFPGEPSGPSLKTEIPGPASKKHTEDLHKVFDTRSLNMLTDYKKSKGNYIVDADGNVLLDVYAQIASIPLGYNNPALAKVAQTPEMVNAIINRPALGNFPPEDWAEVLRSGILKVAPKGLDQVFTAMAGSDANETAYKAAFMWRRQQERGGYDVDFTPEETSSAMDNKSPGASDLSILSFRTGFHGRLFGSLSTTRSKPIHKLDIPAFDWPQATFPLLKYPLEEHAEENAAAEQAALNEVEHLIKNYHVPPAAVIVEPIQSEGGDNHASPAFFRGLREVTKRHNVLLIVDEVQTGVGATGKFWAHEHWDLPTPPDMVTFSKKAQTAGYYFGNPELRPNKPYRQFNTWMGDPARAILFRAIVDEVERLGLVENTARVGDYLFAKLEGLAARYPGQFANLRGKGQGTFIAFDNPRRDEFLKKAKGLGINIGGSGESAVRLRPMLIFQEHHADILVEALEKIVKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQY1</accession>
    <name>A0A1B7YQY1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Choriogenin Hminor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162962.1">
        <property type="nucleotide sequence ID" value="XM_018298146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQY1"/>
    <dbReference type="GeneID" id="28862253"/>
    <dbReference type="KEGG" id="chig:CH63R_03171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03171"/>
    <dbReference type="OrthoDB" id="4114825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF1">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="233"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="884" mass="99767" checksum="57DE62D7AF62B6C5" modified="2016-11-02" version="1">MWSSRHRRYSGTTHINMPVPPADLSHASAFTMTGRRYPRMSLPPTPTMSTPTQEWVPKKLGITMEGRVPQNSKVKRWDGAARSCSDWDNLRRDPELWFRGGNCFVHLYGKGQSRRGPAFKVPFGALLSAKCHPFVKRFMSRDTMPESPVSFDDQYDDLDRWNALNPNEKVELYIPAPPMADKEQSFAYHLATRNFFAWIFRRSVVGEHLGTALIGLLNSMAEFRGNDQDNIPDLMSYLDEEGYLDIKGQPHQALALLNLSEFFQMRDMYIDAFSHCVGMSEELPYSPEYQHIGSVTKTHIRRAVANMNARLSKAGGMLNLFLEEELSETHLGLPAGGRAHLDRFRAFTKSFYTTKLGAYPPLSFDAQKNPVFEPEVLAIMRKDFQAVYELLVDESFTSAESSPILAQGGICTYQSVNDFDRRCKFQSLRHPLPLLPEPAGDRSARRVSLQWLANTTRGDKLKPDQRLVAHSALIKAMNMRDQDLLENDFVRAYRKFEEDSVSPLSRVDKVEKISLVDARKVRWILIYATYQVLLSCTQAPPEVRDVEKVGYHLAVSTEKLPPWKEGRNLQSLLRKQTDLTTNVKRTQSVTDWASKCNAVPSLIVTPTIDIRPDIDYMARSRQEEERVSRRQSECVSSTGTGAARSRSRSLSRSNPFRRSLSIFRKLEEQCAPAPAPRKASYCEIVVHGYGNGTNAVKKSIIPPPEVSPRTVTAPRSFSTSSESSSVSEPQSLGAFSFATAESTAPPTSPEAVCKNWPNQGSPMLSPVPLRGRRRVKAVLAFAEPAEPPRASSPHFSSPELSDKRRHSVMSYAHDYEELIKQQESDFHRHELEPLPLQIRKTSMPLHTELHAESPVLGTIDVDIKPEWEQYKDLGGLTSLSPLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR52</accession>
    <name>A0A1B7YR52_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163046.1">
        <property type="nucleotide sequence ID" value="XM_018298230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR52"/>
    <dbReference type="GeneID" id="28862337"/>
    <dbReference type="KEGG" id="chig:CH63R_03255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03255"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601848" evidence="6">
        <location>
            <begin position="17"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="554" mass="60637" checksum="06EC65111844CAAA" modified="2016-11-02" version="1">MKRLTLLFAWATAVSATSFRQGGRGLRLDHGFDEDRSAAAAVSPHKARPGHEKHRFLNEKTSKFSVNGTNIPNVAFDAGESYAGLLPVDTSQGANETQELYFWFFPEETPSENKDIVIWLTGGPGCSSIGELLQENGPISWKPGTYAPVRNPWSWHRLANVVWVDQPVGTGFSRGPVTATDQRDVARQFLGFWRRFVDTFDLRGYNVHVAGSSYSGLFTPYISAAMLDARDARDADADDAGYFGVKGMMVLDPVLSQGVLGQDFGVARVIDYWGPAFVLNDTVRATIAEIDDRCGYAAYVDRYLTFPPSGPQPAKIPGAFRWGDYVPECDSFTAFAEAAKDANPCFSIYNVLRTCPLPFDPVAFSEGTGYHPTDGPVYFDRADVKAAINAPADAEWRFCSKDPVFVDDLDRSQDPGPGSLPVIPGVVERTGNVIIGHGLRDLIMQSTGTLLAIQNMTWAGAHGFQRRPETKLRIPYHSNADLGTLAGAGELGVWHEERGLTYFETPMAGHFLGRDAPSISFRALEVLLGKVEDFGSRAPFSTKAKDLGIISEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRE1</accession>
    <name>A0A1B7YRE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163110.1">
        <property type="nucleotide sequence ID" value="XM_018298294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRE1"/>
    <dbReference type="GeneID" id="28862401"/>
    <dbReference type="KEGG" id="chig:CH63R_03319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03319"/>
    <dbReference type="OrthoDB" id="4832842at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="27572" checksum="44C6733C288AB416" modified="2016-11-02" version="1">MMVSDTFSLTHKVAIVTGSSRENGIGAAIARALARNGGALAIHHVSKASAPRAQAVAQGIVSEGGRACVVQADITSPAGAKKLVAETMRAFGVDKVDILVNNAGICVGGDLLDATPEQMLAEFNLNTFAPLYMVQAVVKEGRMPRGGRIINIGTVASKLGHRGVAGYGASKAAEDSMTEALAGELGRSHGITVNTVAPGPILTDIVIDARKKLGTDPTKPLRSIARGSEEIGQPDDVARMVLWLATENSSWITAQYISCSAGINGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS35</accession>
    <name>A0A1B7YS35_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163376.1">
        <property type="nucleotide sequence ID" value="XM_018295014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS35"/>
    <dbReference type="GeneID" id="28859121"/>
    <dbReference type="KEGG" id="chig:CH63R_00039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00039"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="59" mass="7138" checksum="D977C02C8DBBEE1A" modified="2016-11-02" version="1">MCIIRQVVKEDCGHTTERWTEMCRPARQRGWACQVMVRMETWWEGGYCNACLNYYPRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSP2</accession>
    <name>A0A1B7YSP2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Filamentous hemagglutinin family outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163499.1">
        <property type="nucleotide sequence ID" value="XM_018295137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSP2"/>
    <dbReference type="GeneID" id="28859244"/>
    <dbReference type="KEGG" id="chig:CH63R_00162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00162"/>
    <dbReference type="OrthoDB" id="4848416at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601888" evidence="2">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="632" mass="68488" checksum="59E4EC8EAB7E5A91" modified="2016-11-02" version="1">MLSRYGVISWLALSTLAAANPPAPPPAEQQQCEPKTETVVHTETVHVPTTVHETIHVTVPGEPKTVHVTVPGEKETVHVTVPGEKETVHVTVPTTIHQTVPTTIHEVQTIHQTVPVHVTVPTTIKETIHVTAPPQIVKETVHVTATITTERVKTERVVETQPPVHVTVTQTEEKKVVHTAVVTQSVPVTVVKTEKQEVLKTIIQTQSVPVTHVQTQIHTQTLVHTKVETQREVQTQTVVHTKIETKREVQTVPVTHTQTQTQIQTQVHTVPVTHVVTQERVVSVPVTVPVTKERVVTQDRPVTVPVTVPVHITKVEERVVTQTHVVTSVQQAAPVHVTQIVTKELPPVTREVTRVSHQLVTTTHLQTVVQTSVNNVRETVHVTLPPHTVRETVHVTLPPQVVKETIHVTQPPQVVKETVHVTQPPQIVKETVHITQPPQVVKETVHVTQPPQTVHVTQPPQVIHETVHITQTVSHCATTVAAPVLGHEPSPPPAAHPPAASLPPPAHEVTPPAHQTMAPVNPHEPAPPAHTPPPAEHVPAPAPPAHEAPVSVAPPAHLQPPPAMAVPVHMMPPAEAAPPVHPAPPAEAAPPAHQAPPAEVMPVHTPPAEAAPVHPPAEAPAHPMRMRFMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT36</accession>
    <name>A0A1B7YT36_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163722.1">
        <property type="nucleotide sequence ID" value="XM_018295360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT36"/>
    <dbReference type="GeneID" id="28859467"/>
    <dbReference type="KEGG" id="chig:CH63R_00385"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00385"/>
    <dbReference type="OrthoDB" id="3638982at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="274" mass="30326" checksum="EBEC4378CA8B0899" modified="2016-11-02" version="1">MRASGGLVARFDSAMPQVYNSAEDTLSGLVPSSARHRSKSQVHNLPLCPITGLALYRVYSPISLSLDHHTFFKMRYNQLILSFFLLFTFVIALPTPAPIEAVENQVAADKNKNNKNGTKKTTTKTTSTRTTNNTKRPVVRAADCTAAKKLAAGIVDNIDIQKRELTEVAAVKKIVTSKDINKTQFKQAKDRLMQTVKEGMTVREKNEKMANTAKDTIVIKGLKTVADAQKKELNQVKDLKGTKADVDIINTLESEFKAGMKKNDENRRDALKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT42</accession>
    <name>A0A1B7YT42_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163733.1">
        <property type="nucleotide sequence ID" value="XM_018295371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT42"/>
    <dbReference type="GeneID" id="28859478"/>
    <dbReference type="KEGG" id="chig:CH63R_00396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00396"/>
    <dbReference type="OrthoDB" id="4845755at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="22129" checksum="20BC2083749251E9" modified="2016-11-02" version="1">MYYRPAMLLGIKTLRKYQVGNVLKACDFWKEALNGRFFYFKFADSKKLASFEIPLRMAHIHLYTENMEEEYADEIRQMKIALAKVTLIVLPFLRRQFWFVAHVQKLWETLAFPWRSEMEDLYHDGLLPDFPTCFDENLQWVEEKIDSDRYPVPDGNPSSSGMPYSQASINEMTRRLTMAGYDSGYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTX8</accession>
    <name>A0A1B7YTX8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">BAH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163980.1">
        <property type="nucleotide sequence ID" value="XM_018295618.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28859725"/>
    <dbReference type="KEGG" id="chig:CH63R_00643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00643"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000899">
        <property type="entry name" value="PHD finger and BAH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="8">
        <location>
            <begin position="251"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="9">
        <location>
            <begin position="544"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="975"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1082"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1412"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="130"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="179"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="197"/>
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            <begin position="213"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="474"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="1293"/>
            <end position="1317"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <begin position="1419"/>
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            <begin position="1450"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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            <begin position="1479"/>
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            <begin position="1519"/>
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        <location>
            <begin position="1583"/>
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        <location>
            <begin position="1674"/>
            <end position="1685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1685" mass="184236" checksum="698335324B4E865F" modified="2016-11-02" version="1">MAQKTQPASSSEDQSPSATPSAQDASDSTQPAVSGASTSKAASAAQKLHQTELDAALRNTSQSMAKSSPTGSDPAAKDAGIEAANPYGTRSRNRNGSSRPNYAEDKDLDVDMYDYAPEKKDQESKKSARHSNVSATSAQEGARANGSTRKALPSDDTKPTTPQNGAKDVQPSNPPATPQTPATTTSTQPSKKRKAASHAATATSQAHASAATPSGTGTGASRKTASGPYASSYAETNMLSFGNSRAVPRDGKLVADDGTVLAPNGEPYYLGRIMEFLHMQNDQTKPVDALRINWFYRPKDIGKKVNDTRLVFATMHSDISPLTALRGKCQILHKAEIPNMDEYRKISDCFWYEKLYDRYIQKNYDLIPTSTIVNVPERVKKVLDERWKFVIVEQGRGKEFTSAVKLCKRCSGYCASNDSVDCAVCKKTYHMNCVRPPLLKKPSRGFAWSCAACSRAQERKLEARHTPNLLDPVGDGDDEDLYDDDEDEMQIDTERTSPADDDDSHRTGTAEQIYQASLWPWRYLGIHCKPEDALDYDDRIYPRASTRIGPKHQAPVLPWPGQPVQYQKPLEIKRTGKKGPGLSKEALAALEAEKSRRENRPKWVQDEPPGYVARGEDYDSDDPNATATRLWAPPPLSDRNKDWEAKVDQYMKKAEELAPKFGLPKNSTNLHDVALETYFHSGYNEERAVKLFSEVDKAAFKEPDLTATEQKKFEEGVGKYGSELYLVKRHVKTVPPGTIVRYYYTWKKTAQGKQIWGNFQNRKSKKEAKKAEVAASKLQDDIADDADDSAFDCGKAHNKKKGFVCKFCHTKYSRQWRRAPNASGTPVSESGGKNSTKDKNNQYIQALCRRCAELWRRYAIQWEDVDEVAKKIAQAGGRAWKKRQDEELLKELEAAKEMHTYWNTPPPVSAPEPVTAAPIPPSEPPRKKLKGSAPDRDSEPLASDSAPVAAPVKRKEKAAEKPAPPPVPEIPKPKTMPCAICDQLEPLGDQHLSCRECRLTVHRNCYGVVDNRNPGKWTCDMCANDKSPQVSIQYKCVLCPVENTEHDFVEQPKISASKKKSEKEKERERLEREQAQKAADYYRKKQEENNRPVNPREPLKRTADNNWVHVTCAVWTAEVKFGNAKALSPSEGIPSIPRTRYDEVCKACGFKGGACVACHHCRNPVHVECARQQGYVLGFDITPVKGSRRDQFNLVTINGESGVMAATVWCKDHVPTKSVIHRIHDIVNDDGLNALQLYVQSYKQADLTLTGTVRKANLMANAAAKLGGVPVTSGPRRASTTTLPTNGVAHSGNNNNNNNNNNNNTTTNNSSSSNTNNDETSSDHQAGEKICITCGIDVSLKWWPIENSDERELTNGHYGSLGSEAQKFVEQRKFQCHKCRKLKRKPNPHPPKDPSPVIEAVRLVPPPLPVVPPHHALAAPPPGPPPLRSPPTTGPEARARSLSSYAWVAPAPPPPPPASQPTAAPPPAVPTAPPVQAAPAPPPIPPPAPHQAPSPYGPPPAPRYGDWHSRPPARHGSPPQRPPPFQPLSTLRPPPMAVPAHTPMPAAVPNGHMGQPAHNGMPPSSLVPGPGSMSHGSHGTHGTHGPHSSHGSHGSHGSHGSHGSQYIHPYRQSSHGLPLGLPNGGPPQRGPDAFAQGLLPQRAPYGSPPAHDAGGPLRTPNMRPANEPPRPAGASTSPSLRNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUH5</accession>
    <name>A0A1B7YUH5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164223.1">
        <property type="nucleotide sequence ID" value="XM_018295861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUH5"/>
    <dbReference type="GeneID" id="28859968"/>
    <dbReference type="KEGG" id="chig:CH63R_00886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00886"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="385" mass="43257" checksum="F0467FACC10D7A30" modified="2016-11-02" version="1">MSSSQTPPAQPIDPEWARESNTAMIVGVTGGFHALALLFVGLRVYTRMAIVKVMGRDDIVVVASVLCAVAGMTIFSVQAFYGLGKHSLIIPEEDMVVMRRSSFFQSIISSIAGLALLKVSIGLSLLRLSRSTWYSRSLWALIAFVSAYSFMAWMTFFFFCQPLEGYWDKSLKPKCYPITLFIKFGLINTAFNIFTDVCFATLPVSIIWTLQMKLRTRIYLIIVLSLGYFAVAMGIIKSVYQIAYGKDTDKTFYQSIQFWEFLQLNLGIIAACAPSLKPLVGHALKISSGDRYHGELYENRRPRGTRTTTNTSKRRQGYRVHDSRGEFEMHDRPFAGSPDVRRTTVVDDAYAYEKDGSRGSGSEDMILKDDGGRGIMRTTEISIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUL7</accession>
    <name>A0A1B7YUL7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LYAR-type C2HC zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164169.1">
        <property type="nucleotide sequence ID" value="XM_018295807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUL7"/>
    <dbReference type="GeneID" id="28859914"/>
    <dbReference type="KEGG" id="chig:CH63R_00832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00832"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="436" mass="48857" checksum="AC5352CA023B1C6B" modified="2016-11-02" version="1">MVSFSCESCGDVLTKKKLDPHRNRCRGATFTCIDCMVYFPGTEYRSHTSCMSEAQKYQGALYKEKNNNNNNKKNKTHNNQSQPAPVHEYEAMAQHAYVEEVPDAEFESFPYEASDNGNSPVELLPEAPTPPSANEGNVNVFDFLDPSATPNASTLGAKDVTEETQLVRYEYEAEAYLDDDGAMMNEDRRALVQYGTGPIPTTGYETPAPKHERRRKDGSEKKDKKRKRLHVDTDQMMVDAPPTLAHSGLTGGLNRMMRPAVFPPSPDYSGGDVADPGLTSPLRKTKSSKHKKEGGIGNNLLGLLSMNSAKTKTKTKAKKRKVSSSTKKHSHHRSDGEKAPKLIEYRPGSRDSKKDEDGDDEGQMVVYRPRADLFLSFINKGPESERGCSMNKALKRFHRERSSSEDTLGKLSEEKELWRSLRLRRNERGEIVLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV40</accession>
    <name>A0A1B7YV40_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164339.1">
        <property type="nucleotide sequence ID" value="XM_018295977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV40"/>
    <dbReference type="GeneID" id="28860084"/>
    <dbReference type="KEGG" id="chig:CH63R_01002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01002"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601965" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15215" checksum="EAE132C59F72E7C6" modified="2016-11-02" version="1">MPRPLSLSLSLSLSLSLSLSEDVWYGFGSQAGQRGNKTPIRLGFPENRCTPSILATERVNVRDVLGFLPGGNEVSSCRCTCRAVQRRKAVQRKRERPSPAEDRDAFGTKRIRGGAILRNNRFPGVFSLTEEHGLASGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVK9</accession>
    <name>A0A1B7YVK9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-binding dehydrogenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164602.1">
        <property type="nucleotide sequence ID" value="XM_018296240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVK9"/>
    <dbReference type="GeneID" id="28860347"/>
    <dbReference type="KEGG" id="chig:CH63R_01265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01265"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR16085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="40234" checksum="DFDA13023E819DB1" modified="2016-11-02" version="1">MGSIGHHSVPPALPDRQRAVVQAEGPARKLQIVTDRPVPKPASDEVLVRVHAVAANPSDWKMTTQFPCPGAGCGMDFSGVVVATGHGLDPALGIRVGDAVAGAVHGANPLDPQAGAFAEYTCALADLLWKIPRPWDLTDAAAVGGCCVATVGLGLFADDALGLPFGLDQFVADGKAPFVLVYGGSTASGTMAIQLAKLCGYRVIATCSPRNAAMVESYGAERTFDYRSPSCAADIRAYTDNTLHHVLDTIVDPKSILVADKAIGRSGGRYAGLEALPEDVLNGSGTTRRIIKWTYVMGTSMIGREEGLTGPYYSKPRPERRAFGKWWFRTVVQDLVDKGLLRPHPVKLMEGGLERVPEGVDMLQKKLVSGEKLVYKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW69</accession>
    <name>A0A1B7YW69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164797.1">
        <property type="nucleotide sequence ID" value="XM_018296435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW69"/>
    <dbReference type="GeneID" id="28860542"/>
    <dbReference type="KEGG" id="chig:CH63R_01460"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01460"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="123" mass="14257" checksum="DCAD03FADFE27DCD" modified="2016-11-02" version="1">MKRFLDVVETDSFDPSSWSTFLRTDAGQGHQNLDPGSRDRADENASQLLEELRDDSPEDLGLSMNHMEDANHRHTARHTMDLRVFPWYKELFYLAMEYVVVVAHTIGLGQDFYFEGVKYSPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWF0</accession>
    <name>A0A1B7YWF0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164886.1">
        <property type="nucleotide sequence ID" value="XM_018296524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWF0"/>
    <dbReference type="GeneID" id="28860631"/>
    <dbReference type="KEGG" id="chig:CH63R_01549"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01549"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="39993" checksum="9DD4ECDC809AD756" modified="2016-11-02" version="1">MGDKNLRTFRYHPAPCRVVRRKQAGANEDHISSAVTIGASEGDWKSAFDQKTLGDVSASHEGLLILATRAAEEPITNSHETTILSKLPFSRPSWLQIMEKFHIHDSVARLINRNTAAEFSRSQMNPNNIDGLALSKFPCHQKEGFSLTVAVYNCRSSASWPGDIALSVTWFPKRWKWYAVFYGCDNATAKNIEHRLNNCEDATCHPLILLGIFAEVERRRQISLVDKGSLDFLSAVSSLNSTNHQLDDSDHASAGSRDNSLAIDPWLKLSHLKNGIQNWKDQLLKMVAHADELNESYFKSDSNSTVAVNELRSQMRRIGGRIKDRLEDIIRDCDEQMRKCQTNLDGIILADQMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVY0</accession>
    <name>H1UVY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04570</name>
        <name evidence="9" type="ORF">CH63R_08841</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000331">
        <property type="protein sequence ID" value="CCF32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155838.1">
        <property type="nucleotide sequence ID" value="XM_018303815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVY0"/>
    <dbReference type="STRING" id="759273.H1UVY0"/>
    <dbReference type="GeneID" id="28867922"/>
    <dbReference type="KEGG" id="chig:CH63R_08841"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08841"/>
    <dbReference type="eggNOG" id="KOG0310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021102_2_1_1"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="385"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="535" mass="58397" checksum="45BBA6B474BCC1E6" modified="2012-03-21" version="1">MAALVGPLPQVKLPSGPSPVTAEQRYWKSFKNQLQIPSPTSYPITHISSTSSDGMFAVTTGTRVQLYSSRTRKLEKTITRFADVARSGSLRRDGRVLVAAEDTGRMQVFDTHSRSILKTWTKHRQPVWATRFSDAQPTTLLSASDDKTVRLWDLTANDPTHTFVGHSDYVRCAEFFPATSPSGVSNMLVSGSYDSTVKIWDPRIGTNAAVMTFKHAAPVESVLPLSSGTTLLASSGPNVSVLDLVAARPIHQISNHQKTVTSLSLASNGTRLVTGGLDGHVKVFETTAWNVVSSTKYPSPILSLRVLSASDSADHADRHLVVGMQSGVLSVRTRLTGPEATRHKEREREMAALIAGTLDQHDSVTKTRKRKAAAHRRLETLGEGQAEVIVAQDARVSRAKEAAWQKALRHGRYASALDQVLDPQGKDHSPLAVLTLLLALRHRSAVRDALVGRDERTVQPVLKWTCNHIIDPRYVSVCVEVGLVLVELYAEYAAASAELFEGFRTLRRRVGNEVEKAQLACETGGMVESLMMGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXJ3</accession>
    <name>H1UXJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_05029</name>
        <name evidence="7" type="ORF">CH63R_11824</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000505">
        <property type="protein sequence ID" value="CCF32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153639.1">
        <property type="nucleotide sequence ID" value="XM_018306798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXJ3"/>
    <dbReference type="STRING" id="759273.H1UXJ3"/>
    <dbReference type="GeneID" id="28870905"/>
    <dbReference type="KEGG" id="chig:CH63R_11824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11824"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013994_1_0_1"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="85"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="703" mass="77719" checksum="23491321E0253871" modified="2012-03-21" version="1">MASSNGVKRKSAPAGKGASDGKFSKKAKIDSTKKAEPVETLESDNEDDFDNESLDSDDGGVQLNPRDRAQQAQAKGKKEGANGADKNKAFERGQNSRESHAIQKKLALERKAAKPLADELARTKKIWERLRRKSHVPSEERKQLVDELFTIITGRIKEFVMKHDATRAVQTALKYATAAQRKQITRELQGTYTQLAESRYAKFLIAKMVVQADGEIKDLIIPEFYGKVRKLINHPEASWILDDIYRQIATKEQKAILLREWYGPEFALLERSKDEKPTSDLAEILEKNPSKKQPILKSLHDMINSLVQKKMTGFTMLHDAMLQYFLNIKPGTEDFNLFVEMIKDDEEGDLLKNMAFTRSGSRLVALLLANGTSKDRRNLLKAYKDNFVLMSGDAFAHIVILTAFDVIDDTKMTSKAIFPELIGDGKETATDNIVVSTTNPYARATLLYLLEGQSRALFPANMSENLAILKEVHEIRQATSKKDAEVRRKELVAVISPALIEAVVSAAPALVADPFGCQLVADVLLSAEGDKTAALEAVAAVAEGDPSAEPMEVEGITTPVHVSRTPYGGRLIKTLIAGGKFNKETGKVEPVEPPLKFADILYPVIKDYILDWATGPSSFVVLNMMEAEDFSHASALKKTLKKHKKALEKAATEETAEQKESKEAMAQKEREKSEKGAKKGKKGGAKSDKPVGNLGSKLLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYJ2</accession>
    <name>H1UYJ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_05307</name>
        <name evidence="7" type="ORF">CH63R_00031</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00031"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
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        <property type="entry name" value="RNA polymerase ii, chain L"/>
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        <property type="entry name" value="RNAP_P/RPABC4"/>
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        <property type="entry name" value="RPABC4"/>
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        <property type="entry name" value="RPABC4/Spt4"/>
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        <property type="entry name" value="GEO11084P1"/>
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        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
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                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
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    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
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            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="322" mass="34982" checksum="1E95485FA84C1917" modified="2012-03-21" version="1">MTSFGYDQFVAFGSDSAGLERILRGLQALTAIFGAYPSLVSLLLLAPGAPYPPFLEALGPLRGHLNLTRRFIRFFWFLNSFGASYNIYTSTPSSSSPVPPAGTPQGKNGGGVAVGLETWLDILRFTLLGLYGGLESLTLPDLLGVPRLEFFGAERTAALNVEAQRFWLLALACGVLANLTRMLKAFAYAPVPQHGHGYGTGEEAGKDGDKNAGEKKEKDGEKQDGDGEEPLDWEAERARLRAIVVKRREERKRWRRHVAFQVKSLGRKVFSDSLDCLIPGVVLGWVNVQPGTVGVAMLVTTVLTSKDIWERCGAAVAAKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0R9</accession>
    <name>H1V0R9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05928</name>
        <name evidence="5" type="ORF">CH63R_02087</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000905">
        <property type="protein sequence ID" value="CCF33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161878.1">
        <property type="nucleotide sequence ID" value="XM_018297062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0R9"/>
    <dbReference type="STRING" id="759273.H1V0R9"/>
    <dbReference type="GeneID" id="28861169"/>
    <dbReference type="KEGG" id="chig:CH63R_02087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02087"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="32982" checksum="078B6B85CCD703BC" modified="2012-03-21" version="1">MPFSPEKDIPDLSGKVIIVTGGSSGLGKESALQLAKHNPAAIYLTARTEARGAAAIREIQAAVPSAKDTIKFLELDLGSFASVQKAAATFLASSDRLDILMNNAGLLASAAGLTPDGYETQFGSNYMGPSLFTKLLLPVLARTAERPGADVRVVNLSSELFKQAPKGGILLDSVKTPMHNISSVARYGQSKLADYYHTRVLSRLYPAIKFVGIHPGVVNTGIFDDLVSRQPWLSGVAGVIGSVFLTDVRTGVRTQLWASTADRATVKSGGFYNQKIKEFKEAILYDDKAAQELWDWTEREFESKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1C3</accession>
    <name>H1V1C3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalytic activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06097</name>
        <name evidence="3" type="ORF">CH63R_10861</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001167">
        <property type="protein sequence ID" value="CCF34500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR10354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">IMI 349063</strain>
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    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001207">
        <property type="protein sequence ID" value="CCF34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018157248.1">
        <property type="nucleotide sequence ID" value="XM_018302470.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V304"/>
    <dbReference type="STRING" id="759273.H1V304"/>
    <dbReference type="GeneID" id="28866577"/>
    <dbReference type="KEGG" id="chig:CH63R_07495"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07495"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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    </dbReference>
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        <property type="term" value="P:intracellular protein transport"/>
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    </dbReference>
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        <property type="term" value="P:protein secretion"/>
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        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="651"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="802"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="917" mass="100984" checksum="8F61D9C19418A93E" modified="2012-03-21" version="1">MSYGKKDEDADLGLVKVDRTQVFQEARLFNSSPIQPRRCRILLTKIALLLYTGEKFPTNEATTLFFGISKLFQNKDASLRQMVHLVIKELAHSAEDIIMVTSTIMKDTGGSTDAIFRPNAIRALCRIIDATTVQSIERVMKTAIVDKNPSVSSAALVSSYHLLPIAKDVVRRWQSETQEAAASTKSSSGFSLGFSSSSGQLPANNSTMPQYHAIGLLYSMRMHDRMALVKMVQQFGAAGAVKSSAAIVMLVRLAAQLAEEDPSLRKPMMQLLDGWLRHKSEMVNFEAAKAICDMRDVTDAEVSQAVHVLQLFLTSPRAVTKFAALRILHNFASFKPNAVNVCNPDIELLISNSNRSIATFAITTLLKTGNEASVDRLMKQISGFMSEITDEFKITIVEAIRTLCLKFPSKQAGMLAFLSGILRDEGGYEFKRAVVESMFDLIKFVPESKEDALAHLCEFIEDCEFTKLAVRILHLLGLEGPKTSQPTKYIRYIYNRVVLENAIVRAAAVTALAKFGVGQKDPEVKRSVEVLLTRCLDDVDDEVRDRAALNLRLMHQEDEISEKFVKNDSIFSLPYFEQQLVMYVTSEDKSAFNSPFDISQIPVVTREQADAEDRTKKLTATAPSLKPPKVGPTKAAAGGAEAAASATAATQRYAQELMQIPEMKEFGSVLKSSPVVELTESEMEYVVTVVKHIFKEHVVFQYEVKNTLDATVLENVSIVATPSEEEELEEVFIIQAEKLPTNEPGKVYVAFKKVNGEGSMPISSFSNVLKFTSKEIDPTTNEPEDTGYDDEYEVAEFDLAGSDYVIPTFASNFNHIWEQVGAAGEEAEETLQLSSMKSIAEATEQLAKVLSLQPLEGTDVPVNQTTHTLKLLGKTVGGGRVVANVRMAYSSKSGVTTKITVRSEEEGVASLVVASVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3B6</accession>
    <name>H1V3B6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_01187</name>
        <name evidence="13" type="ORF">CH63R_09961</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">IMI 349063</strain>
        </source>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
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        <property type="match status" value="1"/>
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    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="174"/>
            <end position="202"/>
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        <location>
            <begin position="256"/>
            <end position="293"/>
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    </feature>
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            <end position="78"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <end position="51"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <dbReference type="EMBL" id="CCF34718.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="OBR05841.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3Y7</accession>
    <name>H1V3Y7_COLHI</name>
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        <name evidence="10" type="ORF">CH63R_01608</name>
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    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164945.1">
        <property type="nucleotide sequence ID" value="XM_018296583.1"/>
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    <dbReference type="STRING" id="759273.H1V3Y7"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01608"/>
    <dbReference type="eggNOG" id="ENOG502SNI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_3_5_1"/>
    <dbReference type="OrthoDB" id="4848072at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="405" mass="45018" checksum="168296ECD218B1F3" modified="2012-03-21" version="1">MMNNTNGTAADFIDPAWAAESNTARILAVVTVFHVLALISVGLRVYARVWVIRAAGWDDLMIILSAVCAIGGWSIFIVQADHGLGKHFKTIDKKTDYVTFQHASFWQTIISATGALMWLKLSIALSLLRLSTTKWFKWSLYAILGIILFYSLGGMLAFSVTCKPLSGYWDKFTDPPPKCHGHGYVNTFGMVNTAFNIFTDVVLSTLHVPIIWNLQMKLKLKLYAIGILSLGYFAVAMGIVKSYYQATADSDSDKTFNRNIQFWGFLQLQVGILAACAPALKPLANSLLDLSTHNSPARGPFSKHSKQSSSGVRTLASIRSRNQEQARRNQYELGEWDEGTAIGYGEREYSRTMRDTTATAMFTDEGPSREDVRAPGRLADYNSFKGIIKTTEFSVTQEGRADRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5I9</accession>
    <name>H1V5I9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Duf341 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07263</name>
        <name evidence="4" type="ORF">CH63R_11490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001561">
        <property type="protein sequence ID" value="CCF35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153305.1">
        <property type="nucleotide sequence ID" value="XM_018306464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5I9"/>
    <dbReference type="STRING" id="759273.H1V5I9"/>
    <dbReference type="GeneID" id="28870571"/>
    <dbReference type="KEGG" id="chig:CH63R_11490"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11490"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_4_1_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="257" mass="28425" checksum="A6352AF94B03951A" modified="2012-03-21" version="1">MRFLCLHGMGTNSNVYEAQLAPIIAQLDPGHEFVFVDGLVDCEPADKVDAIFPGPFSCYYDKPVLSQLQDAYDVIYEVLREEGPFDGVFGFSQGGALAASLILHHQATNPYAPDLFKLAVFTCASLPFDPESHRRVNKYHATVCPETGAVRVRDWAADERVEALQINGFLRDAEPGDVILRRFHPARETARIAVPTVHIMGARDPFCPQSRLLAELCAGPAEIVAHQQGHQLPRDWGFARKAASSIENCIHRALSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5L6</accession>
    <name>H1V5L6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00206</name>
        <name evidence="7" type="ORF">CH63R_00790</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
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                <person name="Duvick J.P."/>
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                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Proctor R.H."/>
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                <person name="Rech G."/>
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                <person name="Rounsley S."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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            <strain evidence="7">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <strain evidence="9">IMI 349063</strain>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
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    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="69442" checksum="73EF06FEBD1470CC" modified="2012-03-21" version="1">MAASISACFEIVSLPTYRCLRHFTYHVPKISLHVPLRMSRRSSDGKNSNSETHAWRVRGRTVLRRMGEIFWIVVIYIASELLIWCLSLALRLAGLQFLSSILGMLLVFASMVSISQLRPGSDGFYRRNIKSKVDFINSNLGVGFPVPIIIITKEQILAGKGIGRVIGNFFFTNVIFWVLGCFISWGILAGILGPPPLSHCRFTNSELEQAWQPEAAAASQPRAEAPLQTISRRASDTTTLNGTVVTGYHTDKEAGLGPESRTVSAYFTDSDCPTTIQPPNAAGELSSRSSFSVPRRPDDSRSEHNRLSSWAKECYPMALALFFLFVVGIPVSSATRSDWAMEGCMIWFTWVSSTRLQRGFSRSHLFADSPGFKTTAVTLLNPVLLTTLTMVAYTRAKAAADNLPIELKLILFSSGNSLSDLMTAAVDDQTLREGGRIWFGAGDMALSILECGIVVWGFKLFECRRQIWSRAGAAVVLISVGMAALNVFLSVIIAIKTGLGGGESLSFAARSTTLALARPAMAALHGNRSVNAALVVSNGILGQLMYPYVLPRLGIEGRDEEQQDEGDKSARDDALTIAVGAAIGINGAAMGVSYLYERENRAAPYAALSMTVFGVMTVVFTAVEPFTTVLLTITSEQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1V779</accession>
    <name>H1V779_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01428</name>
        <name evidence="3" type="ORF">CH63R_12632</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001824">
        <property type="protein sequence ID" value="CCF36081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152023.1">
        <property type="nucleotide sequence ID" value="XM_018307606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V779"/>
    <dbReference type="STRING" id="759273.H1V779"/>
    <dbReference type="GeneID" id="28871713"/>
    <dbReference type="KEGG" id="chig:CH63R_12632"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12632"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005193_1_0_1"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="871" mass="92796" checksum="9A594DD28C12E3FB" modified="2012-03-21" version="1">MQPARPPPRAPGSFSPLPGSTASNAPSPQRPRPPVRTESSSSEESLSINFVKPRTHAPSAPTQPSSGTPIYAQFSQANSSTASLQNFSRPTAQRSGTTPGGPSGHSLGGGNDPSVSANAVTAARTASPFTKGHSRKHSQTPGLFDSTLPSTSTSNLSQVGMSHPSANSSSTNQHQHHHPSPALSASHIAAQAAFQHQTSQQQQQHQQLLHVRQRSQTVPNPANGDGDNVRRGSNGKGPLSPPMLSLTEASGPRENAFGTQGYHKGLLGSHSAAATSAANAAANAAFPRSGQTSPGLPQQQQLHNPGQPPPQLIPDSKPVKPEKSKVKLFSRPVKIGTKGDPKDKPLPSPSKIGSALASLQRGNFSTSSLIDTSGQSIYNLNNSSSATIRAVPETPTMEKEGKEKEKKHHFLSRQKHKLKDDYHLPLSSASSNSKPTDPSAPSSLYSFNLPPSPAPTATSFGKARRDKKTEKESSNLNVESSSLPSEWPGPSSLPSLTHQSSYLSEPIDAGKYGLNSMALDDAWPYLKAKMLVIFEGEDLRQPVEDFNRLVALHIQYCIQRRSPNIILEDLRELLATGFASLDMTLRRTQEDKVIPALVEMWLITYTSILPYMQAVFLPLDLEFSGCGVLMNPDQARDFWGGIKAPSSDSAPYVSPASAVLDVRRIVLTAYRDIVILPRYDSLKAIFSRLSLEFLPSSFASLALASPLPDPALSSSPADTMNMMRPGTAMSLDPSVASYNSNATTLLGDGSAGGGGGGGGGGGRSRGLSNVSYASGGSDGQLRPFTREQNVEDSKQVTEMVGRMLQCMSILASIGGVAGDGSDEGNRRMEELCRLLKLNWLGRGRTGRNRRGIVGGRRREIPESIREGLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7C9</accession>
    <name>H1V7C9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_07764</name>
        <name evidence="10" type="ORF">CH63R_00097</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001847">
        <property type="protein sequence ID" value="CCF36131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018295072.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V7C9"/>
    <dbReference type="STRING" id="759273.H1V7C9"/>
    <dbReference type="GeneID" id="28859179"/>
    <dbReference type="KEGG" id="chig:CH63R_00097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00097"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_014658_1_0_1"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
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    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
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    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF36131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="718" mass="81366" checksum="CB225C3163783B06" modified="2012-03-21" version="1">MCGITATIQLRRERGSHSVNGHGQDSLQKHDTLRKQLAESLASIAHRGPDAEGIWISEDGGIALGHRRLAINDLTPDGVQPMHSDDGKIHAVVNGEIYDHDAIRNRCIRDHGYKFKGHCDSEVLVALYKIHGAPQFLDHLRGEFSFVIFDETDGRVITARDRFGIKPMFWTITGEQGSPERRLLLTSEVKGFLPLGWEPEWNVEGLVSGSSLCAENTVFKDVWKLNPGTWMEISRDGEIKHHQYWDPQYKDKREVETRTVDEIVREVRERMVEAVRLRLRADVPVGIYLSGGIDSSVVAGIVTKLVREEGVMLGNQDATKRISCFSIQFPEGSGFNEADIAERTANWLGVQILKKDMNEEELAKNFADCVYHNEQHHFDLNSVGKFCLSTLPRQHGVPVVLTGEGADEHFAGYPFLLPDFLLEPDYAWPDSALAKNNSMRESMQKEMTDDIKNMFKTVGMFDHHWEKTPPSTPHLEIANNALKWQPHWELFAPWVRETYGQTDMREIVARTMSPEVLENVREKWHALHSSLYIYTRGPLANMILTCLGDRTEMAHSIEARPPFLDHHLVEYINNLPPSLKIAYNQAEGQTDGTGSSMWWKNLSSARQALSEKWVLKEAGRPFITQELYERRKHPYSAPVKWPRGGPLHRMFTELLTQASVANLGFIDWGDVEGWLEKGFGEDADPNAFRKLVIVGCWAVLGERFKVKTAVKAEGSGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7X0</accession>
    <name>H1V7X0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport membrane glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_07916</name>
        <name evidence="15" type="ORF">CH63R_00731</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001927">
        <property type="protein sequence ID" value="CCF36322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164068.1">
        <property type="nucleotide sequence ID" value="XM_018295706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7X0"/>
    <dbReference type="STRING" id="759273.H1V7X0"/>
    <dbReference type="GeneID" id="28859813"/>
    <dbReference type="KEGG" id="chig:CH63R_00731"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00731"/>
    <dbReference type="eggNOG" id="ENOG502S7WD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038503_0_0_1"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="13">
        <location>
            <begin position="182"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF36322.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR15551.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="405" mass="44529" checksum="72797508D766B5DF" modified="2012-03-21" version="1">MSFEGLQERLTALQETTAQLKELIDRLQNLDFPPGSVPLGADEENGVGAELSSEISQILREEDDELELLGEEVEDLRDGRPGSEAEHTKTRLKDGVERLRQELKSSRVTFRKAQLTARRNLSHAQRLERELLLQSYSQPVSEAPSPSLGAQKPDVIRHRQVHQTTQNTSSLTEDDKQTVGASSNVTSALRRTHDLIAAELARSEFAHQTLTESSAALAQLNDSYGSLDTMLASSKDLLGTLLRSQKSDTWYLQTALYMLMATGAWLLFRRLLYGPLWWLLWLPLRLMFNITVGGGGAMIKYAGSGEPSEAVVVNEGKIDVEGLPDDSLPTVVVAREPQRSAASGDDPESLVNKVGRIVEEMPAEIGEETTTDDGDPVDVGAAVDQTSSDELKQGAPEEVRQRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V807</accession>
    <name>H1V807_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plant Basic Secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07947</name>
        <name evidence="3" type="ORF">CH63R_07769</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001943">
        <property type="protein sequence ID" value="CCF36359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157521.1">
        <property type="nucleotide sequence ID" value="XM_018302743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V807"/>
    <dbReference type="STRING" id="759273.H1V807"/>
    <dbReference type="GeneID" id="28866850"/>
    <dbReference type="KEGG" id="chig:CH63R_07769"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07769"/>
    <dbReference type="eggNOG" id="ENOG502QURC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062644_0_0_1"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="301" mass="33494" checksum="74FD16EA423D762E" modified="2012-03-21" version="1">MSSAAEESTSSGAPTSTPVPAPPAETPLPPRPKSPGQQKLIPAAAANHSRPSPDFNLPKLRLEIRDLKDPAAVHFLSAVNASDALTTAVRSVLTLLYESPSCNTTHVPPTRSVTLILRHMDGVAYTTGSELDDDHKEIHFSMSYIAGIPAERRTDEIMGVLTHEMVHCFQYNAHGTCPGGLIEGIADWVRLNAHLSPPHWKRDASGNWDGGYQHTGYFLDYLEARFGAGTVRRINEKLRNRRYKEKEFWTELLGRPVEQLWKDYGEKTKDDETVIVNKDDISDDDVRLGRFRAADENPVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBD8</accession>
    <name>H1VBD8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08846</name>
        <name evidence="4" type="ORF">CH63R_06446</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR10754.1"/>
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        <property type="entry name" value="Kelch-type beta propeller"/>
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        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
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        <property type="entry name" value="TIP ELONGATION ABERRANT PROTEIN 3"/>
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        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
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        <property type="entry name" value="Kelch motif"/>
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    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10754.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="416" mass="44424" checksum="1236CC4F2744169E" modified="2012-03-21" version="1">MAEIAAGALVAEQIVSTGVEAGAAVAVARPTQPLKASLSQVATTQSPAFDVSALARSHHSVTVVNHKACIFGGETAEGQLSSTDFHVLSLPAMTKGEPVAAYACYPAFAMQDAETGKTYVPSPRSRHAAAARGQFVIIQGGADASGKPIEETCLWLWDSESLKWTKMEGASQIGKTLTPRFDHHIFVDEAQDFLVLHGGRTSKGQEASTETWMYNFDSLAWTELPPSPQAPLAAALVDNVLYTIGADSSMSGAIHYLDLKSNAEDREKPNALEWKTVNFPTNPLTPGPRPREGGALVPVNTGVGRHYLLYAFGENSNSAEKDFYSDIWALQLPTHGFSAAAVKDAIREKLPRVDSGEFSWAEVELVATEEVKTEGKAHPGPRGFFGADAADAKSLIFWGGVSALGKEGDGWLLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCR5</accession>
    <name>H1VCR5_COLHI</name>
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        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_09220</name>
        <name evidence="17" type="ORF">CH63R_11364</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002758">
        <property type="protein sequence ID" value="CCF38018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306338.1"/>
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    <dbReference type="STRING" id="759273.H1VCR5"/>
    <dbReference type="GeneID" id="28870445"/>
    <dbReference type="KEGG" id="chig:CH63R_11364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11364"/>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_0_1"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_asu-like_sf"/>
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        <property type="entry name" value="ATP_synth_asu_C"/>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="424"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF38018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="555" mass="59824" checksum="62DA76DE45C0C9CA" modified="2012-03-21" version="1">MFRNALRQSTRAVGAVSAAGRVAAVRNAAPAVYSATSMQTRSYAEAKASPTEVSSILEQRIRGVQEEAGLAETGRVLSVGDGIARVHGMANVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGQIVDVPVGPELLGRVIDALGNPIDGKGPINAKEKRRAQLKAPGILPRQSVRQPVQTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNSGNDETKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFTGASVGEWFRDNGKHSLIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDKLGGGSMTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKQTLSRGERLTELLKQKQYSPMAVNEMVPLIYAGVNGHLDNVPVAKILQWESDFLGHLRTNESDLIATIDKEGALSKDLEARLKDVVVSFTKSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEX1</accession>
    <name>H1VEX1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01982</name>
        <name evidence="3" type="ORF">CH63R_07352</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003146">
        <property type="protein sequence ID" value="CCF38774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157105.1">
        <property type="nucleotide sequence ID" value="XM_018302327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEX1"/>
    <dbReference type="GeneID" id="28866434"/>
    <dbReference type="KEGG" id="chig:CH63R_07352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07352"/>
    <dbReference type="eggNOG" id="ENOG502QWAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007520_1_3_1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="941" mass="105408" checksum="2DBDBD4B3CA0EDD3" modified="2012-03-21" version="1">MAMSTSFPTSANTGDEPSGIEYEDWKNTLLQCLEGIGSFYEIASSSRYTMFPNPGLEIEGHPAFPLPLTSAHAQLIKNACRPASSGREANTPFDTPVQNIWELNRRQFKLLNPEWDAFLKEVATEAAHSLGLTDIGLMLHKLLLHEKGFSSQNYGDTEESPGMIGTLFICLPSEHLGGDVHISFGPDKHHFITAPTSKYDLTALAWYSDVSHKTKEIKSGYRLALTYSIFQRGSDKKSAALVGQQTHMIRKHLLEWQTRFPDTETLIRPLDHSYSEAELSISHMKGYDRDVCRTLHSVASECGVYLFFAHLRPVNPGPGRHGYNVDERDTHAIHRTMYSPNGKPIGFGYTPKPEEMLDLEGDLDNDDERSFTEEEDVEDASDYYRTAAFLVKKKSVHRYMSHISPNSPSGYSFANTNTENMVEMVVDDMRDFMKNQDMGEHARPPILEVLRKALGPNESSRALTPVVVKWALKLKNMGLYQSAMMAAAKSGIEDILESAIKTACGFVEHHFGDVPGHIDWDKWMENVAPMDTVIDVHVTIQNFTSAFKKDAVRDSFFKWGDSKLTDKLDTQASFEISELPFFIVILGGKHSKRDWLKARLITALASSGTRELLYGVLNTVLFWRSHEECPVAELLFEQVFNRSFGRLLLHGADLRPKPAGPGSLTCGPPTRCIPPCRGPLKDFAKIVGQIMHLGLASEGIELLEASCDSILRTKATWCHKKLGGDVTTELIVPLIKIFKEHNIPVTQGAKSLFEVVLREGLYENIPPNPPEPRRWAHRSRTCSKGRDGQGPNCRDCEAMDAFLIAPDQRVWKYQAEKPIHDHLKSQLRAGGDGSDGARYFNISTERTQRAHTMVVEKTGREFLDEVESWKESVWALEARLAPLRDEMVAGMLGSRAYRELVLVEDLRAQIVTSGSSITAGVKREVDGSAIPELYSVKRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VG81</accession>
    <name>H1VG81_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_10113</name>
        <name evidence="8" type="ORF">CH63R_02810</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003381">
        <property type="protein sequence ID" value="CCF39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162601.1">
        <property type="nucleotide sequence ID" value="XM_018297785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VG81"/>
    <dbReference type="STRING" id="759273.H1VG81"/>
    <dbReference type="GeneID" id="28861892"/>
    <dbReference type="KEGG" id="chig:CH63R_02810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02810"/>
    <dbReference type="eggNOG" id="ENOG502RZ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043194_1_0_1"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="336" mass="39668" checksum="9613046E0B1EF787" modified="2012-03-21" version="1">MTSPPASPRRRHILSSVNPEERREPAPRLTKHSSPAPGATEPKGEETSAAGDGENLQPKPSRIRLKSKHSRSSRSHRDRDRDDAEDRSSHHRHHHRRRHRRRSRSPTPPDPYEQKPLDPDAAFRESLFDAMADDEGAAYWQGVYGQPIHVYSNERPGPEGELERMTDEEYAQHVRQKMWEKTHQGLIEERARREEARKRKSEEEKRNRKLQEDMERSLRRGEERRRKRMWTQLWEEYAQAWSDWANDVDKIPWPVESRLRRDIGEKEVRRFIVNGLAVEEVGEKEFAAKLREERVRWHPDKMQQKLGGQVDDGVMKDITAVFQIIDKLWADTRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIY5</accession>
    <name>H1VIY5_COLHI</name>
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        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CH063_02296</name>
        <name evidence="5" type="ORF">CH63R_06811</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003924">
        <property type="protein sequence ID" value="CCF40188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159636.1">
        <property type="nucleotide sequence ID" value="XM_018301786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIY5"/>
    <dbReference type="STRING" id="759273.H1VIY5"/>
    <dbReference type="GeneID" id="28865893"/>
    <dbReference type="KEGG" id="chig:CH63R_06811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06811"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_3_1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
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    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="38214" checksum="A3910098756112EB" modified="2012-03-21" version="1">MAALPETSSPAFYVDEDCNFKVIHDVPFPELVDGEVVVKVLYSGVNPADIKHGLGLGIRSTTLGYDFCGRVVQAGPTSEYKAGELVAGYTPTGFGRPLKYGTHKPFLSCPEDMMFKVPENLPPTHAASLTTVLTTAADGLYNIFGYSLPGEKPQDGFKPGPLLIWGASASVGLCMVQLARASGASPIIVTASPSRHELLRKLGATHCFDYRSTDIASRIKAAVEESKAGPILYAADCAGSFGEVTSAAQMEACVGDDAILLSVVKHQDTRYKMPLASANKDVTIRFGNGPVFTIPARMEAWKKMETALAWAVRTYGTEFQLPSVEVFKGSAEDALEEVKKVADQGKFGKLVLEQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKV1</accession>
    <name>H1VKV1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH063_00367</name>
        <name evidence="22" type="ORF">CH63R_05802</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="CACQ02004346">
        <property type="protein sequence ID" value="CCF40854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158627.1">
        <property type="nucleotide sequence ID" value="XM_018300777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKV1"/>
    <dbReference type="STRING" id="759273.H1VKV1"/>
    <dbReference type="GeneID" id="28864884"/>
    <dbReference type="KEGG" id="chig:CH63R_05802"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05802"/>
    <dbReference type="eggNOG" id="KOG2697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_0_0_1"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="20">
        <location>
            <begin position="222"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CCF40854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="866" mass="93642" checksum="D6A4970560A9F390" modified="2012-03-21" version="1">METTLPFPFLISVAVPPGLAKLDGLDREQVSILGAPFFEANDQTLEKFHSFLKQHNAEFRGYFDVTGISSRDDVVSLLDAGARMVFVSPENLAQYEEFGSRVGSVLSTADVPTKAASKHAVLVKDFDSTTCDLGSFIEHCKVEKLPNLFIKPVPESNLEHFVDIAKQCNAVPILPSDGLTASKEESKKLSLSKLISSFWKSDRPDGLIPTVVCDESGTALGLAYSSAESVGEALRTRTGVYQSRKRGLWVKGATSGDTQELVRIALDCDNDTLKFVVRQNGGFCHLDQHGCFGDLNGIPRLEQTLQSRKKSAPTGSYTARLFSDEKLLRAKIMEEAEELCDAKTPQEVAFEAADLIYFALTKAVSAGVSLADIERNLDAKAFKVKRRTGDAKGKWAEKEGIKTATAPAPVAAPAPAPAVKDDKSDRITMRRYDLTKSSAIEIDEVLKRPSQKSPDAILNIVKPIIDEVRNGGDKAVLSYTHKFEKATSLTSPVLKAPFPKEAMQLSPESTKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRFSRPIERVGLYVPGGTAVLPSTALMLGVPAMVAGCQKIVFASPPRSDGSLTPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESVTKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAGPSEVLVIADKDANPAFVASDLLSQAEHGVDSQVVLIAIDLTEQQLQAIEDELHNQAMALPRVDIVRGSIAHSVTIQVKTVDEAMRISNDYAPEHLILQVKDAEKVTEKVMNAGSVFIGEWTPESVGDYSAGVNHSLPTYGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGESVMQLAKTEQLEAHRRAVEIRIDHLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLH0</accession>
    <name>H1VLH0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_11459</name>
        <name evidence="13" type="ORF">CH63R_05262</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CACQ02004472">
        <property type="protein sequence ID" value="CCF41073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161483.1">
        <property type="nucleotide sequence ID" value="XM_018300237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLH0"/>
    <dbReference type="STRING" id="759273.H1VLH0"/>
    <dbReference type="GeneID" id="28864344"/>
    <dbReference type="KEGG" id="chig:CH63R_05262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05262"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_13_1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05118">
        <property type="entry name" value="STKc_CMGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF41073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="419" mass="47155" checksum="91DC210F0F1F0D4C" modified="2012-03-21" version="1">MSAGQQSSSSTPPPPSPSPGQCDASPRYIEEGRNAYRPGGFHPVYIGDVYHGRYEVLNKIGYGAYSTVWLVNDKKTPEGEAHKFFALKVLSAECYGAEKDIFEREVLKSLRDGDRKQLGYSHVCHLVDDFEHEGPNGTHVCLVFELIGETLRSFGAWFPDSMIPNQVMRRFTIQLLLALDFAHEHKVIHTDIQPSNIFVKLRDYTLIESGYLVKVAIPHQDRSEEKYTVLPSRPLRQYYFKEDDRFDHFDIALGDWGVSSWADKHLTEKIQPVALRAPEVLIGAPWDAAVDMWNLGAITLELFLAVRMFSGAAPPHGHYELKQHLAEVVNLFGPFPKALLDKGDQDVVEAVFDDHGMVKGLPPSSMDTPDDLSDYFPPEMDADVGGEFIAFMQSLMKIDPAERPSPEDVLRGPWLRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLZ4</accession>
    <name>H1VLZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_02547</name>
        <name evidence="4" type="ORF">CH63R_13386</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004579">
        <property type="protein sequence ID" value="CCF41247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152777.1">
        <property type="nucleotide sequence ID" value="XM_018308360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLZ4"/>
    <dbReference type="STRING" id="759273.H1VLZ4"/>
    <dbReference type="GeneID" id="28872467"/>
    <dbReference type="KEGG" id="chig:CH63R_13386"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13386"/>
    <dbReference type="eggNOG" id="ENOG502QVPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_2_0_1"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF41247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="362" mass="40423" checksum="4886A14F0D519AA0" modified="2012-03-21" version="1">MTDIKKFALGDFKLQNGETLSGAWLAYKTFGDPALPAVVYPTWFSGAIADNEWLVGDDKTLNPSKYFIVIPALFGNGESISPSNSDVNPFPDVSFYDNVRAQYQLVTKELKIKHLRAVLGWSMGAAQSFQWATQYPDFMDICVPFCGAAKCALHNQVFLEGVKSALLAAKKISSAGSTKGRATAAEDKSVRVWTDEEKQVGLKAFGRGYAGWGFSQAFYRHEVYKEHYQAKDLEDFMQNFWEKWALSKDPENLLVMLHTWQDADVSKQEPYNGDFKKAMASIKAKTLVLPSKTDLYFPPEDSEIEVDCMSEGVGELAVFPSIWGHWAGGPPGNFDDVKWLDDKLKGIFSAAPHRDAKELPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSF1</accession>
    <name>H1VSF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rna-binding protein cabeza-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_12944</name>
        <name evidence="3" type="ORF">CH63R_10174</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005898">
        <property type="protein sequence ID" value="CCF43159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154572.1">
        <property type="nucleotide sequence ID" value="XM_018305148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSF1"/>
    <dbReference type="STRING" id="759273.H1VSF1"/>
    <dbReference type="GeneID" id="28869255"/>
    <dbReference type="KEGG" id="chig:CH63R_10174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10174"/>
    <dbReference type="eggNOG" id="ENOG502T15E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719636_0_0_1"/>
    <dbReference type="OrthoDB" id="4843203at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="384" mass="42640" checksum="76BA33FBB05EC3AD" modified="2012-03-21" version="1">MAPQQKNAKKASKESKPRAPQAGIQKSRSTQNKKPTTKKTSTQPTVPAMDPITSRDKEEEGESSWTWTEVPPTKKQTAMNGRQRGRNLVQWNRPGTARTILLNLMYEASIKGIKLPMDAVAHRTHCGASGQSLIQWLARERKNMLKQGRMCPPVAGNNYDPTIRGIVLETAPGGLKTERQEPEDENEDEVEGEGNEAHRSSGAGLQIKQEMNQGAMEQQDVPFYPHNYSMAAQQIESQHPQQMLQAPQIYQAPWVPAPPGTVNPMDLQIDSNSPIFADESQRNKSVAHRWLTEKGHILPLISRTPSGDVQVQPNDLQCSGQNQQASFGPMSYGNMIPNNQFSYNYNYEGMGMNETGRASGSHINLARNDPPLDGPTFSTSNERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSM7</accession>
    <name>H1VSM7_COLHI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_12997</name>
        <name evidence="2" type="ORF">CH63R_07915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005947">
        <property type="protein sequence ID" value="CCF43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157667.1">
        <property type="nucleotide sequence ID" value="XM_018302889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSM7"/>
    <dbReference type="STRING" id="759273.H1VSM7"/>
    <dbReference type="GeneID" id="28866996"/>
    <dbReference type="KEGG" id="chig:CH63R_07915"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07915"/>
    <dbReference type="eggNOG" id="ENOG502T63Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076949_0_0_1"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="270" mass="31560" checksum="591FCE0A64053803" modified="2012-03-21" version="1">MSIKETFPRPEDGHYRWPGLRENRDRDLQAMNCLRVISDSMSACELSNIDYASGSWGYTVLRTTYSDESDRLWPAAMDRLKRWVTEYFVHLNRLITNKLDGTLNDEVARRFVLEVVETEELRGHELSSREHAESLVHIFEIWRHGATGSTDFDTRDNPRFCDFLVIDEDALRSLAALPDETPHLGPVSRTDRRARIGSYIDSYVWLVDSRAVNRYQGVEDGDNYEGWMRLCSEDIYYAWFEKAGRSASDHWTFEQREIPEGSGIKWYQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VST3</accession>
    <name>H1VST3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_03038</name>
        <name evidence="13" type="ORF">CH63R_04607</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CACQ02005990">
        <property type="protein sequence ID" value="CCF43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160828.1">
        <property type="nucleotide sequence ID" value="XM_018299582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VST3"/>
    <dbReference type="STRING" id="759273.H1VST3"/>
    <dbReference type="GeneID" id="28863689"/>
    <dbReference type="KEGG" id="chig:CH63R_04607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04607"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_1"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="887" mass="100323" checksum="75622E4DB6E27954" modified="2012-03-21" version="1">MSGSTEQQRIPLRERRPSTGAPIIDVQGSVGPAGISRPKHKRTFTGFGAGEIKSVEASIPEPQREAWSKAQAGPFKSKEEFEKEVVRHVETTLARSMFNCDETAAYSAASLAFRDRLVKEWNKTQQRQTLVDGKRIYYFSLEFLMGRALDNAMLNVGLKDVAKDGLDELGFRIEDVIEQEHDAALGNGGLGRLAACFLDSLASLNFPAWGYGLRYRYGIFKQEIIDGYQVEVPDYWLDFNPWEFPRHDVTVDIQFFGHVQKSTDSNGKTVASWEGGETVTAVAYDVPIPGYATPSTNNLRLWSSKAASGEFDFQKFNSGDYENSVADQQRAETISAVLYPNDNLERGKELRLKQQYFWCAASLYDIVRRFKKSRRPWREFPDQVAIQLNDTHPTLAIVELQRILVDLEKLEWDEAWNIVTATFGYTNHTVLPEALEKWPVGLVQHLLPRHLQIIYDINLFFLQSVEKMFPNDRDILGRVSIIEESQPKMVRMAFLAIVGSHKVNGVAELHSDLIKTTIFKDFVNIYGPDKFTNVTNGITPRRWLHQANPRLSDLIASKTGGYEFLKDLTQLNKLELSVNDKGFRKEWAEIKYANKVRLAKYIKTTTGVSINPAALFDVQVKRIHEYKRQQMNIFGVIHRYLTLKAMSPEDRKKVAPRVSIFGGKAAPGYWMAKQIIHLVNNVGSVVNKDEDIGDLLKVIFLEDYNVSKAEMIIPASDLSEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGENNIFLFGNLAEDVEDLRHAHTYGSHSVDENLTKVFSAIENGTFGSVSDFQALISAVRDHGDYYLVSDDFNSYIETHNLVDEAYKNQEEWITKSITSVARMGFFSSDRCINEYAEEIWNVEPLKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTA5</accession>
    <name>H1VTA5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_00479</name>
        <name evidence="2" type="ORF">CH63R_02150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006124">
        <property type="protein sequence ID" value="CCF43463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161941.1">
        <property type="nucleotide sequence ID" value="XM_018297125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTA5"/>
    <dbReference type="GeneID" id="28861232"/>
    <dbReference type="KEGG" id="chig:CH63R_02150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02150"/>
    <dbReference type="eggNOG" id="ENOG502SIFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005780_0_0_1"/>
    <dbReference type="OrthoDB" id="423576at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF43463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="894" mass="99397" checksum="7D3FC3C3B462F932" modified="2012-03-21" version="1">MRVPQILLSRVLRGVAVATGSRPAETAPVERWISSIRTVEGSLLDWKAATSGSLSETDGEKTVHLANMVLAICYIREATRKSHEISPAELSQCWEVVRAAIDVLGKDKSLGGFPVSSSLQGLSTVSLCDLSENGSPGEQFHLHIETPRGSRLNRGFDLHSTLSPVHTWILAGEVRNDSYQVDSVSDPAEATHITYTLSRSCAESKGDTGTSAPSEKHLVVEKAGKFVRAREVGSKTHTRNASYSLPADAFQAFEADPDTLFAALTFSEASCGSATDTVVLGPVEGHLSIELPVTTTLAPRELADLVEAARSWEGLIEEGREHARKAEWEYALQAFNSALSLCGPEKSFPNAGFYRHLVLGEIGSVNRRFGRYESARSFLEEAINGLKPCIQRIEFSGELGVTYRHIGQLENASDAFAKQYEVARELGSAREMCRAVGNMGMINYQLSQRDGSEHLLDQAIVQLQERVSLAEDLKRTASLQAGNSSSKHWLHIFETWKTIGLCRLSICHYTRGNVEKAIVTSAEALEMTAGSKDVTVKAMTRFFHGRALMKGGRQEEALSLFNMPGTCSPAIAFAKEPSEEHRGYLQELVDIGADLDIVDEQGYTALDHAVFSGDAITEAVILEGLRKTSEENVAERQTEARLRKGYRELFQERLRPVLLGGGRHVLSKLRKAYAESLETDETKKRAFDGLKFMWYSDFLDFKRLPRSDDGLVREFDSSWTVESSARAAEKVVFISYRWINKTPGAKSPDDDHHTQYHRMINAIDEYLRLTPSVHKDKLGIWMDHACVNQDDPNAGVSALPMIIAQCDAMISLVDEDYYDRGWCAVEVMMAETLRSSYSIHQWYEHVLQPGGSRVQGVLREAPDRPIGMMKDKRLTFETDRPKVLFLERQSKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTP5</accession>
    <name>H1VTP5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03124</name>
        <name evidence="3" type="ORF">CH63R_08347</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006223">
        <property type="protein sequence ID" value="CCF43603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR09582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018303321.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VTP5"/>
    <dbReference type="STRING" id="759273.H1VTP5"/>
    <dbReference type="GeneID" id="28867428"/>
    <dbReference type="KEGG" id="chig:CH63R_08347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08347"/>
    <dbReference type="eggNOG" id="ENOG502RH53">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 5"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09582.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="382" mass="42669" checksum="2A0213F292DC727F" modified="2012-03-21" version="1">MTEPRSTMIRNSKRLPPGKATIPMDSKSLFSASNLSKAAPFLAALEQQLYQPITPRQSLQIRPSQVEEEEMRATRRQETNQYRHDDEKSVYNNYFEVPYETCYSQTAVDEVEGEKEREQRGEPKAKDEAPNPTTAQRQRSVAEACRFLRQFIEARWENQFHAGYIKIQCDLTMAEMWELGRLNKSDGSRECRRLVSAPVIHDAIGYALWSELARTVGNGGAVVLASSSSDPSLSTVVAKLTAAEEVAARRARSTRRRATEGDAIARHPTPFISSTYFSITARVRRKSELQLARPHQLACTKCGGRAPLERMRVDSPLSDDEDAQEERGGNLVDEGEGGLELRVKKRNSISRRLSVKMNQTLARFGEGLATGYGGNGVSRVSG</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
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        <name evidence="18" type="ORF">CH63R_09771</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006619">
        <property type="protein sequence ID" value="CCF44101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154169.1">
        <property type="nucleotide sequence ID" value="XM_018304745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VV42"/>
    <dbReference type="STRING" id="759273.H1VV42"/>
    <dbReference type="GeneID" id="28868852"/>
    <dbReference type="KEGG" id="chig:CH63R_09771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09771"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_019326_1_1_1"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
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    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
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    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
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    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="387"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <sequence length="432" mass="48652" checksum="7AD702C0A8BD622B" modified="2012-03-21" version="1">MKTAIVTSVLATLAAGFNFHKRNPVSYEGYQVLRVKTLSQLATVQEKLASIPHEQWNHDVETHIDIVISPDQVETVESLGLDYRVLHKDLGESISAESQARGTYRRDIDDLSWYDSYHPYEDHVRYFTDLHKAFPDNSELVYSGRSFENRSIHGIHLFGDEGPGKPAVLYHGTVHAREWISAPVVEYLTLQLINAHKNATNATDSILNKYDFHIFPIVNPDGFVYSQEVDRLWRKTRTPPPPNQSCYGTDINRNWEYGWDANSLGASTNSCAQAYRGQKPSDTVENQGLDAYVRKLRDASGIKLYIDWHSYGQYILSPFGSKETWYAPELGKWTKTASVLSEVIRDSSERRTTFTFGPSGATLYTTTGAAPDHVYAIGGADFSYTIELPDTGDYGFVLPPSRIRGAAEEQWEGQQVLYTLLDEVFFDGIGPA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZR4</accession>
    <name>H1VZR4_COLHI</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008012">
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        <property type="protein sequence ID" value="OBR16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555710" evidence="1">
        <location>
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    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16377.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="97" mass="10273" checksum="3268BF80FD9AEB6E" modified="2012-03-21" version="1">MQFSTLLSISLLVLGASAQISGPNGKRFCAGAAISCQYKKGRCANACRDTANDFQNGNAPVAPIYDTVCSCPDGQPGNEYTGAACIDLIRWAQRHKC</sequence>
</entry>
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    <accession>H1VZS6</accession>
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        <submittedName>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
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                <person name="Wittenberg A.H.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF46416.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018297393.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02418"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13692.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="106" mass="11715" checksum="08F0055F870E4973" modified="2012-03-21" version="1">MTPNPVATFRSHTVPTSRTRCIVLVPGVCFDGRIPDTAQSQLRNDRLQIDLLRESVAIIGPSPGCKSSPPKLEIRESVRSEGRPRVFVCRGIEPVAVTLLLIRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2I8</accession>
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    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Sisk P."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02008972">
        <property type="protein sequence ID" value="CCF46701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157240.1">
        <property type="nucleotide sequence ID" value="XM_018302462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2I8"/>
    <dbReference type="STRING" id="759273.H1W2I8"/>
    <dbReference type="GeneID" id="28866569"/>
    <dbReference type="KEGG" id="chig:CH63R_07487"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07487"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:incipient cellular bud site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:axial cellular bud site selection"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:bipolar cellular bud site selection"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:cytogamy"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032507">
        <property type="term" value="P:maintenance of protein location in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF46701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="222" mass="25590" checksum="4493DAD4BD883351" modified="2012-03-21" version="1">MSRLNKHHQSCRELHVVVLGAGGVGKSCLTAQFVHNEWIESYDPTIEDTYRTQLQVDGRQVVLEILDTAGTEQFVAMRDLYMKSGQGFILVFSITSSSSMNEIEMLREEITRIKDDDNVPIVIVGNKADLEEQRSVPRQRAFACSQMWDAPYYETSARTRTNVDAVFIDICRQLLMKDEKFQSQVAQDDDEHEYEKTPGLMGFAKRKNRRRRRPDGHRCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1W397</accession>
    <name>H1W397_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_04000</name>
        <name evidence="10" type="ORF">CH63R_07912</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02009223">
        <property type="protein sequence ID" value="CCF46960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157664.1">
        <property type="nucleotide sequence ID" value="XM_018302886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W397"/>
    <dbReference type="GeneID" id="28866993"/>
    <dbReference type="KEGG" id="chig:CH63R_07912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07912"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_5_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF46960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR09147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="546" mass="59258" checksum="25EFD99435564704" modified="2012-03-21" version="1">MGRSSPNELDKSKPGPAQPTCEETPLLQEHASSPDSAKSRSVSWASIPGKWQLAVLVMARLAEPLSERSLTSYLFYQLQWLNPDLDPAEIPKQAGYLTAVFAAAQCLTSVWWGHAADNPSLGRKRVLTIGLVGSAMSALGMAFSTSLYAAFFFRFCAGALNGNIGVLRTMVSEIVVDKRYQPRAFLLLPMCFNVGVIIGPLLSGFLADPVHTLPRLFGPDSLFGGAHGVQWMRDFPYALPNLFCAVILGTATLGIILGLDETHPQLKHQPDAGRRLGKHIMHTILRRVPGYNDDPGAVGIPSASVQGPIDEEVGALPIKPKRKIRAPFSAILTRQVCLNMLQRFLQSLHVSAFNSIFFSLLPTPRAENNNFHTPFRFTGGLGLSSEKIGLANTTIGMIGIPLQLILYPRLISMLGVRQSYRVFLPLSIVAYFSLPYLVLLPDDAVLIWTCLSAVLTMHVLSRTFVNPATMLLVNDSAPSPNLLGTVHGLASSISSAGRIMGPTAGGAMLSWGLTHDLVGLPLWLLGVLAVINWAVLWWIDDVSMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>H1W484</accession>
    <name>H1W484_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00668</name>
        <name evidence="12" type="ORF">CH63R_04276</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CACQ02009568">
        <property type="protein sequence ID" value="CCF47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160497.1">
        <property type="nucleotide sequence ID" value="XM_018299251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W484"/>
    <dbReference type="STRING" id="759273.H1W484"/>
    <dbReference type="MEROPS" id="T05.001"/>
    <dbReference type="GeneID" id="28863358"/>
    <dbReference type="KEGG" id="chig:CH63R_04276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04276"/>
    <dbReference type="eggNOG" id="KOG2786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5042300419" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042300418" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="229"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="460" mass="48580" checksum="0380A43167B3EF15" modified="2012-03-21" version="1">MAQPVRRFPGHLAQFVRCYSVSAESIPAAKKKYVPTEGTYPQGFQASGILVGVKPGNKTKPDLALLSSDRPCAAAAVFTKNKFQAAPVTFSRDLLKKKSNRGIRSVLINSGCANAVTGKGGLEDASLMAHAADKAVGGEGDASSTIVMSTGVIGQRLPIAKIVDNVPAAQGALGSSHKHWLSFATAICTTDTFPKLKSKTFTLPSSPGVEYRIAGTTKGAGMIHPNMATLLGVVATDAPISPAVMPSVLKHAVDRSFNSITIDGDTSTNDTLALLANGAAGGKEIVSEDSADYAAFKEVLTDFSIDLAKLIVRDGEGATKFVTIRVVESASEEAARKIASTIARSPLVKTALYGRDANWGRILCATGYSLVSEPGQAVSDVPEVVPEKTNVSFVPTDGTPELKLLVNGEPEMVDEARASEILELEDLEIIVRLGTGDKEATYWTCDYSHEYITINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4N6</accession>
    <name>H1W4N6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ferric reductase like transmembrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_04161</name>
        <name evidence="13" type="ORF">CH63R_02580</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009734">
        <property type="protein sequence ID" value="CCF47449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162371.1">
        <property type="nucleotide sequence ID" value="XM_018297555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4N6"/>
    <dbReference type="STRING" id="759273.H1W4N6"/>
    <dbReference type="GeneID" id="28861662"/>
    <dbReference type="KEGG" id="chig:CH63R_02580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02580"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010365_3_1_1"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="289"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF47449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="583" mass="64704" checksum="6726BC9A5B45BFAF" modified="2012-03-21" version="1">MAGGGATKSPEEQQAAIDAALENKALSNYLFYICASVSAAVIIWRVWTVIVKYVRTVACLNNDNQRYFAQSDSKVSWMKKNVLYAPVLSKRHNREIQLSSAINVGTLPSRLQLLFLAGYLATNVAFCVINIPFAGSFAAAASQLRNRTGTLAVVNMIPLFLMGGRNNPLIQMLGISFDTFNLLHRWFGRIVILEALAHTLAWMANTANKSSWETAIKSATTVPFLLFGFVATCAFVAIGIQASSPIRHAFYETFKLLHILLAITAVVGTWYHLQMKALPQLKYMWPVVIFWAGDRVWRAARVFYGNVGHGGSKALVEALPGNACRVTVTMARPWTFGPGQHAYMYMPAISLLQSHPFSVAWSEEAEDPMAEKASLNRQDILAMRKTTMSFVIRARTGMTDTLYRKAAACPEGKMTTTCMVEGPYGGLHSMRSYGTVMLFAGGVGITHQVPHVRDLVAGYANGTVAARRVILVWTIQSPEHLEWIRPWMTEILAMEKRRDVLRIMLFVSRPRSTKEIHSPSSTVQMFPGRPNIETLIKAEQESQVGTMGISVCGPGALSDEVRRAVRDRQHDSAIDFNEEAFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQH0</accession>
    <name>A0A1B7XQH0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150534.1">
        <property type="nucleotide sequence ID" value="XM_018309562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQH0"/>
    <dbReference type="GeneID" id="28873669"/>
    <dbReference type="KEGG" id="chig:CH63R_14588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14588"/>
    <dbReference type="OrthoDB" id="4848850at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="224"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="474" mass="52120" checksum="2108817CC5F4C100" modified="2016-11-02" version="1">MLDSSLEKAITYWLSTITAAKHADPDEVPDKVPDSDPRPRKRQRVACDASEGPKAKSQILSTRTDAVGTDSITQFLPSPDSSPAPTATPNYRALPDMERPPRTPSPHKRLYGAADGPQPTVALEEETPRAVAVAMDSFDLSSQLSFETASSATHSTASAASRSSSPNKRLRNAEILWSGFTTDKFLSSTPRPQSLVALHDELNSIRLGLRVIPCQFQSAGSSIPPHAFFDPAADPTTVTDWRIPSLNWVSRTVEEATRCELSRDAESDWNHAVHARVLNWVCAPEDAPRGLVAVKHCTTAQILKEFRPKGAPTHMVDYCLVIDPTREVAACQRINTICRSRPGASINHTDMGSLATHPIAVSIETKRPGEEWSKAMLQLGTWHAAQLRSLENLGHCPTTSAMEFLPALIVQGHDWYFVATVPRSDAPPTVFTRVRIGSTEDHFGVYQLVLALQHVSRWAEQVFWPAMRSEILDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQS6</accession>
    <name>A0A1B7XQS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150640.1">
        <property type="nucleotide sequence ID" value="XM_018309397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQS6"/>
    <dbReference type="GeneID" id="28873504"/>
    <dbReference type="KEGG" id="chig:CH63R_14423"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14423"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="170" mass="19160" checksum="B1294B05F867A12E" modified="2016-11-02" version="1">MTDGPWDRSTRQNLHFIVPFGRNENFVGRDAILTQLLERVHPAAYKDTCQRTAIVGLGGIGKKQVAIEAAYLVRDAHPSCSVFWVLAVDMSMFERAYRDIGQKLEIQGIEDDQADVKSLVKTALEPDDIKSWLLIVDNADDMDLLFTSSKLMTYLPSSRRALFCLQPEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQW4</accession>
    <name>A0A1B7XQW4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150673.1">
        <property type="nucleotide sequence ID" value="XM_018309430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQW4"/>
    <dbReference type="GeneID" id="28873537"/>
    <dbReference type="KEGG" id="chig:CH63R_14456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14456"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="180" mass="19124" checksum="C7532EA1B0B714C5" modified="2016-11-02" version="1">MADSDDDSPLLGDRLERHRVALLPTSQAPSSAAGLSQSPKRPFPAELKLSNAPAKRARSSTSSTARVKPIFAFGRRSSTVSPFAPLEPLAPGLNRFAPPSRRLLLGTPPSASDSPRRPESTSDAADGSRDPLLYTQLCIRDGTAGRLTAPPEYHDLMQVLVGPPALAQVAGGERLAMEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRE2</accession>
    <name>A0A1B7XRE2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150860.1">
        <property type="nucleotide sequence ID" value="XM_018308542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRE2"/>
    <dbReference type="GeneID" id="28872649"/>
    <dbReference type="KEGG" id="chig:CH63R_13568"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13568"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="149"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="371" mass="40587" checksum="DA30DBA8C2E7A205" modified="2016-11-02" version="1">MGKPIVLQLGDDIKWNHDLYKDFTSRFEIRRSYSMPRAEFIQALKDKKFGDFFAIYRPFWNTGGEMGNWDKELISLLPSSCKVYASAGAGFDWVDTETLASRGESPPILLLTVDRTRDIRHADSHLHPGIVYCNAAAACTESVADGAIWLILSTFRLFSWSSAAARSGDPDQFVDANKNLGAVSRNPNGFTLGIIGFGRIGRRIAEKAHRSFDMKILYNDVARMPAEAEKGSDATFYGDMSDLLAAADCVIVATPFAGKTLLDAAAIGKMKKGARLINIARGKLVEEEPLVAALKSGHLSAAGLDVHYNEPHVNKELIKMRNVEVLSHNAGASLDAHMGFEKLGMQNIISFAETGKAVTPVNAHLITKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRT8</accession>
    <name>A0A1B7XRT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine and deoxycytidylate deaminase zinc-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150962.1">
        <property type="nucleotide sequence ID" value="XM_018308644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRT8"/>
    <dbReference type="GeneID" id="28872751"/>
    <dbReference type="KEGG" id="chig:CH63R_13670"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13670"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601011" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="139" mass="14911" checksum="A40AE06AA7C93141" modified="2016-11-02" version="1">MLRSIILLVLGAVTASSAHFVIPNDDQDMSGLTVNSIPAVKRVEYMRKANEALFRQSGPCPFAAFGTIIVNHTSDEVVCEGANFRTGDPTIHGEISAINACTARFAEQGMTPSEIYAAWGDLSIYTNAESCPMVSLPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSE1</accession>
    <name>A0A1B7XSE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151162.1">
        <property type="nucleotide sequence ID" value="XM_018308844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSE1"/>
    <dbReference type="GeneID" id="28872951"/>
    <dbReference type="KEGG" id="chig:CH63R_13870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13870"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="190" mass="22160" checksum="B9CA43F497D2A052" modified="2016-11-02" version="1">MSETDLSVLCGYDWHWDSKNENIITFGEDGSGKLICRAELNVWIAAEFDWKLLGIGANKQQSDEDKRWWRSGRNVDPRTETVLMLEMTLTKRRIPSLGEADMSRYTINEDILTDDAFKSKRMHITLETGTFGTQFDARQKEELPETPKFKYRLTFDVSPYPKRNQWKDPDGAPDAMKFWEWTQFCGCQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSE8</accession>
    <name>A0A1B7XSE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome p450 pisatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151172.1">
        <property type="nucleotide sequence ID" value="XM_018308854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSE8"/>
    <dbReference type="GeneID" id="28872961"/>
    <dbReference type="KEGG" id="chig:CH63R_13880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13880"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="58160" checksum="9EB64F8DE13DD39D" modified="2016-11-02" version="1">MNTHLVLAVGAFALLAQLTITLIRWFRSPLRSVPGPWLARFTNLWYFYRVKRGNFEKLNVQLHERFGPIVRYGPNRFSFSDAESPKTIYGHGTQFPKSDFYTTFQPSEDMWNMFADRDIKHHAHTRRFYANAYSMASLIHYEPYLNECGALFSQRLLEFSKAGTAADFGHWFQCFAFDAIAMMTYGKRLGFLDRGEDIANVIDNLDNNLLYASMMGIFPALHKFAMPLLAMIDARIGSGTGMYVIDFTRKTIGDERASPKSVAEATYQEDGAAVGETFLSKFLAKHSNNPDEYSNFHVLTGCASNMFAGSDTTGISLSAILYNLLKNPDSMGRLREEIDDFTRRGELSQAPSFKETQKMPYLQAVIKEALRVHPAVGLPWERVVPEGGATIGGRFFPEGSIVGINSWVQHRNKALFGEDAELFRPDRWLISDEARLSVMNRNWMPFGLGSRTCMGKNISMLEMSKLIPRIIRDFEFKLEGPSAMPGCSWETHNAWFVKPRKFYATVRSRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT01</accession>
    <name>A0A1B7XT01_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151394.1">
        <property type="nucleotide sequence ID" value="XM_018309076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT01"/>
    <dbReference type="GeneID" id="28873183"/>
    <dbReference type="KEGG" id="chig:CH63R_14102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14102"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="429" mass="47211" checksum="442F946875BDD5B1" modified="2016-11-02" version="1">MPAPDAPMSWTLSRHVAASKPREPLSQVPCHWGVRHPSSHDLPACSASPLSPRTPQNRNSPQTKSHTHRSPAHKRRHRPVRMFVICPPSPSEAPSTASIHISSMSSNPLLPLQFPTPASLADLHSHLASDALDHLSSRPPRILIARAVGAVPNSALCLKAKALSPSNTPDSGNGSGTVASFAKWDIVRPRRHRNPPAFPPLSSPHPPPLSKLALGSQRLEPGRVSKGAWHELNGGDAPLWRQHHHQEAEEAEAETEEEDGQHEKRREEEDEEEAEWPASANREYLTAYSSAASTARREAMGSRPFLRLLRLDRLLTYHGSPLPDRVRWYFCCPAPGGRRCPTGSLDLTFICTDLQFRGHGVGTSLMRAVTEVAKTEGLPVFLESTIDAVPFYEKLGFVRVGGFRMSIPVDGPKEGFYEEVCMLLEQEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTK4</accession>
    <name>A0A1B7XTK4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151596.1">
        <property type="nucleotide sequence ID" value="XM_018309278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTK4"/>
    <dbReference type="GeneID" id="28873385"/>
    <dbReference type="KEGG" id="chig:CH63R_14304"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14304"/>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="190" mass="20678" checksum="C299E403E23C2342" modified="2016-11-02" version="1">MPSVSTTDALAAQWIKPSDISTILFILGGDVVQKAFSLGTGKVYIPVCFSFGCAAYAFIALVGIIGDGRLLSPSDYACKVLNLGSEYVRESRNFVLGRLLRDLEAIESRRAGRKDENSDYSLRISVYEAQWNGNAPTEFSWSHIHLIGAVVTLIQFGLALVPLVINRSWSVLLITAAGTVLVQWTGLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTZ4</accession>
    <name>A0A1B7XTZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_12364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151755.1">
        <property type="nucleotide sequence ID" value="XM_018307338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTZ4"/>
    <dbReference type="GeneID" id="28871445"/>
    <dbReference type="KEGG" id="chig:CH63R_12364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12364"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="10">
        <location>
            <begin position="353"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="574"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="795"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR03237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="835" mass="93099" checksum="F6FA2237A12FE1D0" modified="2016-11-02" version="1">MVASLSGTSPTLLRYLCPLLVLCVSARRLLPFWHQLAAGSLDSRLPAQNPRSPSSPLLFIDSVFINFFLILLLFLLLLVFLLSPLACELHLVDDSLELPLASLLIPIFPQIEIPAPKHLEVAIMVTPKQPGRQFSLGASAHRRRQMSNMHDQGNHFGPALTTLYCGISAVFADSHTAVVALAIHDTVYLIDFTVKHINLDDATQTGNDAIADYIISTLEDYEHANFSKFIGAGLPMTLKYMSQSLCSRLWLDLDIVPVVLRPDDEHKEKSFWDIKRVDEQADSMARKCIMNFGPSLVPLLQVGWRGVVQTDAGFRVQLNTVQNHKDTCGTPTWDATMFFAKKLRENKIKVAFFSSTPQGGGVALMRHALVRFARLIGVDLTWYVPKPRPGVFRITKNIHNILQGVSHPDQRISAEEKQSIIDWITENANRYWLSEGGPLRPPEEGGADVVMIDDPQMPGLIPLIKKITPDRPVLYRSHIQIRSDLTAKAGSPQEDIWNFLWSNIQHADMFISHPIPIFVPHTVPKEKVVYFPATTDWLDGLNKPLNRWDTGYYGHIYNTACRNQGMTELEWPARKYIIQVARFDPSKGIPTVIDSYAEFRRLLEEKGETDIPQLVVCGNGSVDDPDASMIYDQTMNQLEKHYPHLVKDCSIMRLDPNDQLLNTVIANAHVVLQLSTREGFEVKVSEALHAGRPVIATRAGGIPLQVKDNVNGFLVEPGDFKAVAGHLLDLFTDNELHKKMSYAAATGVSDEVGTVGNALGWFYLAAKWAEVGVKPGLRGAERWVNDMAREEAGKPYTEGENRLPRHFTQKKDVAIVSGKTNGNGETGEKGGEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUH2</accession>
    <name>A0A1B7XUH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151937.1">
        <property type="nucleotide sequence ID" value="XM_018307520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUH2"/>
    <dbReference type="GeneID" id="28871627"/>
    <dbReference type="KEGG" id="chig:CH63R_12546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12546"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="525" mass="58388" checksum="BE47B7143355B253" modified="2016-11-02" version="1">MAVETSINAEQPKPKDLEIAEKRPSVPGSIDGDLKAGQVELLDEAEIFLQQNGISHAQMRELFEDEDAKKKLVRKIDLTLLPLLMGTYLLQYIDKQALSYGAVFDLFETTNTTQSQYSWLASIFYFAYLVAEWPASYLAQHFPTGTVVSVFVVSWGTVLTCTAASHSFAGLAVCRFLLGAFEAVITPCFMMIVSMWYTRAEAPMRAGSFYCFNGFGSMVGGILFYGVGQADGWDVWRIIFVMCGGLTIAWGIFLFFYLPNNIMTAKRYTVEEKALLIARSQSNNTGVFSRKIKPAQIKEAFRDPQVWLLFFYTLLNEIVNGGIANFGKLIVKGFAKDALLTTAYGIPYGAWVAFFIFTGPLCAYKFKNFRTIVMMTWVLPTLVAVSLFLKLDRANKNGLLMAYYIVGESSFVGALVVALQMPAANVAGYTKRVTSTAFVFLAYCVGNIIGPQAFLASEAPIYGTGCKVIMGCTAGQVVLAISIRILLKRRNKRRDAEAEASGQDEDDEVLMDLTDFENRKFRYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV43</accession>
    <name>A0A1B7XV43_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152128.1">
        <property type="nucleotide sequence ID" value="XM_018307711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV43"/>
    <dbReference type="GeneID" id="28871818"/>
    <dbReference type="KEGG" id="chig:CH63R_12737"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12737"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="300" mass="32401" checksum="A1D5E6DC380EF5D6" modified="2016-11-02" version="1">MGERVQCELVLSTRPAHQDPFHHFRYAAHVIVVDLFILPCVHAPFRLAGYVEPDGSPGRIDLAHSPDSPRSQPGPAQPGSRRLGGRVGRFKREKARGGSTASDPAGPAIRTPGRAGCETLSEMSIRRHGADVQQIPSIIPEDDGHYGTSLPFVWPVSDSAAHIPRPVRPVRFPAAQLPSCPKRKAERGQPSGSSKAKLVDRTGSHVLGCDNQGNATLRHAEARTSECHPAPSPGTATPAAVLNQCKQPAPVLGAQIILAQWLFECSQRLKPTPAAHDSEPLGRARRTSIRTRGFASFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVC1</accession>
    <name>A0A1B7XVC1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-3' exoribonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CH63R_12833</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152224.1">
        <property type="nucleotide sequence ID" value="XM_018307807.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871914"/>
    <dbReference type="KEGG" id="chig:CH63R_12833"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12833"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="22">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="21">
        <location>
            <begin position="2306"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="497"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="818"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="903"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="972"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OBR03706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="3582" mass="397011" checksum="48F4E636049C2979" modified="2016-11-02" version="1">MGIPAAFRWLSNKYPKIISPVIEEQPVKMEDGSEIPVDTTGPNPNGEELDNLYLDMNGIVHPCSHPEDRPAPKDEEEMMLEVFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRSAQEAQEKEEDKQELLKLLKQQNGGVVSDDSLESVTKKAFDSNSITPGTPFMDILAASLRYWCAYKLNTDPAWAKLKIIISDATVPGEGEHKIMNFVRSQRISPDFDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQDSKARMCKLCGQKGHEARACRGQAKEKVGEFDEQEKNLALKPFIWLHVSILREYLAAELNVPGLPFRFDLERAIDDWVFMCCFVGNDFLPHLPALEIRENGIDTLTAIWKDNLPFMGGYVVKDGHVDLGRAQLILNGLAKQEDAIFKRRKETEDRKEASFKRRKLQEERNPRFAKPKQVDNAAAGLTLFPAAGGPNGITHDMVVGRSSNMNANTANKSAASAIRDQLKGLMSKTEPGQAADAGEKANGEVPSTPDQKSVLGKRKAEEAAAQAGSTPASATGPSTPSAAEEAAVDHVRMWEEGYADRYYEQKFHVDRSDHEFRHKVARAYVEGLSWVLLYYFQGCPSWEWYYPYHYAPFAADFVDLDKMEVQFEKGRISKPFEQLMSVMPAASRSALPEVFHDLMLNEDSEVIDFYPTEFEIDLNGKKMAWQGVALLPFIEMPRLLAAVEKKYPLLSAADQARNGVGRDVLLLSDAHHELYDEITTGFYSKKQGAPTLKLNPRTSDGLAGNVEKIPDYLPHGELVYPLERGGMPNLDYDRSLRVWYTFPTSTHPHKSMLLRGVKPPAPALDRNDIETLKGKSNRSGRGYGGVPFQRGGHHDGGRRGNFSYAPAGGHGRQDRGPPSHSSNNYGHGQHGYQPPGPPPIQSSWHPPPPGHPGFGMGLPPPPPPAGYGNDGRVSNGSYRGGAYGQNQNYGPPPPGPNSHYGHTDGGQQGGRGGYQGRGGYSGGRGGSSYGGGGGGGRYNGGRNNYRGTRIVLLSESGSSSSKPTIASATAIRRFIPLPHPPSVAFAFTLPLRTYFSFSSSPLASTYIRELFCNVVAKSQSELEDAERHTGAEMNGDAGLVGCLVDRLATRLPHRTGTHGQELQQDEIVLITRSTLVKISTSALAFVLDSLVALLEDIIRNYKGIPPPTHPPHVLLSEVYVLALAADCCTAHWDHVKAQGLRQPPVSTDPRRVAPAIVPEPLDEGLVNRVFDLVKWLVEPIPEGYVLPSSTILDDTPRHTDSVARSTSGLPSPLPVDADASEDDDALPITQLAVLEPCVRVIVEYVTASTWSCSFDYFRNVVYTVRTAAVVQAAPGQSAAAPDDDKASLAVLKILSFFWVDAQKLGLIIQEICSSFLHFRKSFQNTVAVVAPLLITRWLDRHPHEFVQQHTLHKRLDGGADTLFDMTQTVVDNGRKKGMLYPLQTTLLFLLPDVFEVASNLREAKSSSMAKKVGFLDNLRKALRNKNEQAAYSLVSLLRASRHFIAEDDAALVSYAMDVQDEVREAVFRRGNDSSLFDQDLMTAAFVSLAELSLDSCVDSLSQSYLSLSSPQAFKTAVVQGCRYFARQNDSRVYEQLFAMAGPFMRTQLKAVADLPAESTAVALALPRRDSNLHSFTNMACDVLKFLDASPRSLFDGDGQAEPTTGAADEDVFLSFLSCVVSANPTIRRLATGVAKRLFSDNSILDTLHSCGRLTSATLKREFWRRSSLVLLNMCNDVTSDGDGPTIKAIHEYLEARKFLLASLRELSDIPEGVSEIEAASSRLETTLLVSLCSADVETCQTVTACIGLFFEENSLVDVASDAAKGFATLLRNGEVYGEIASRAFRFTGLVAFQKRVRGLLRRLQYPTSGILSAWEYGFERWLLLSREVSMAPVDAVDERTLTEWRNYSGFLASLGGICTANQAIILEEPTLGVLRWIDRLPSENHEEPLLGRYLKLSIQLLGCASVRIREATREVLSSEVSSTLYQSLFKALESELEVLFTGALAPSDKAQDVEIIFAEQAISLLKALVERLESPSDLGAASAIHLGALALNFAKFLDGVSDSTNTLRVKIKVCQLCEAVTKRKEHLNLRDDVRIRNQLLEYIFGWIARPRSPRLDSTTSSSGGRLDEVVRVQKDLDKACLKSLAELTFRLPLQPGEGQTDAGTSELKSQMFHTYFNRFLSLLNHESPEGARNELMAGMSSRDEGGSSSEYAITILSNLLSANIDVGLKHSLNIGYHDNVEIRTAFVKVLYNILIQGTEFSNLTDAAVSEKYDELLELLTKDMTLVAAMSAVCPSSEVDELTVSLLTIFEHRGLSFELLEVLIKQEIQETDNESEILRRTCVATKMLSVYAKWKGQPYLKATLQKVVERLMLTSKDLDLELDPARVGSTDELQKNALQLRIVAKVFIDDICASSSSMPASFRKICNIISTAVLPRFQEAKYTAVGAFVFLRFFCPAIVAPEVEGLVSTTPSKEMRRGLLLIAKVIQNLANNVLFGAKEPYMFPLNDFLTQNIYRVTTFLREISVPPENLETPPTIESFDFGSCVALHRFLYDHWDHMRQRLVTQERRDFVRSPAEVSRGRSPVLEPLRNLITNLGPPPLAVTWNRPQISSNTPPSYSRFQNFMLRNAFRSTESFITARAVYDGGESKDSLSIICIILRHIDAENIDYDTLLYCYLKIASRLWHKPFGLLIDATCYNGQNEPQDDLFKKLEQLTPVELSKNLVRIYVYNMNSAFRKCFRRLLRVSAKSDNSVFNPKNVDYHLIGSLQDLQAHFHLSQLHLPKETISVVTDTRYVFQPITRLSKTKGKIEVVIKVGSQFVQVTTTKKQEVFPGYRLSTTVNDIFRLGEVEEAPTSIQTEDDSAFGLRADNGKIVMYFTSPKKADVLQTIRGAKAKYGKDTRTHKAYERLIRPQDVPGTLLNLALTNLSSSDHVLRLSSYNLLGALCKAFKFGAASNLMCTKDVSVPMDPSHFIIKISRQLATSEPQLTFDFLTEFFVGWETFTEEQKPLSLAYMAPWLPGLRTAVLANEPDAEKGKEKIAALFRKLIDVAISDHGLTYTLEQVVWPAIYQDETILDIFLEELMRAALSFSFAEEPMEALSSIVSGMGSITLRGKVISRLRKALNRSSLRPTKYLPDNAVWAEICVLLHFCLSLSFDNGVQSQLYLPEIFHIVTILANTGAPEVRLLVHRLLVNTVHAACTSFNLDDTRFNKLRGSLDFLSEPRSEIFSAPPPFLRDGASMSTTQEAGPSLTATENLAAVLFEVCSVAAPSVDISNAWRSRWMSLVASTAFQNNPAIQPRAFAVMGCLAREEVDDDLLYQVLVALRNSVGRLGEDTNSDMLISIVTSLSKMMAKLPSASRYGLQLFWLAISLLRLVPPALFNCTAQFLEAVMTNISTVGDLRGDKMGPLLLQGRVQLEEAALPLDDAYGIHFTAENFHFAVCACLARGLADTTTKTNATRVLSAFLDMAGNPVGGAGHPSDDISRSPYMALILARTVGSDELRDSLWLAGINPLLLGDVTGIQRYEDLGGMKDKDLLLNTAIELIDFQYLEDALQNRTLRWLTELATVRPAVIMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWF3</accession>
    <name>A0A1B7XWF3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152611.1">
        <property type="nucleotide sequence ID" value="XM_018308194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWF3"/>
    <dbReference type="GeneID" id="28872301"/>
    <dbReference type="KEGG" id="chig:CH63R_13220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13220"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="157"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="433" mass="49594" checksum="2776904BE4A20194" modified="2016-11-02" version="1">MNDPLRPTSLPAFPSNQQTHTAIMATDVHKKIDPEQVPAAAPKAGLTRKPSDPHPAGRVKYSFPMQLLRGLTFGLYFAACCLAIITTQMLGIPLYFYNREMFYAYMALTKQSFGLTITAMTHMWSNSTIRISGDKSMNGQIRKTPDGRVEFNFPERLVLVANHQIYTDWLYLWWVAYANAPSMHGHIYIILKESLKYIPGVGIGMMFYGFIFMSRKMATDQPRLAHRIDKLKTRHVAANGKEYLNPMWLLLFPEGTNLSTNGRRKSAAWAAKMGLKDPEHVLLPRSTGTLFCLRELKDSLEYIYDCTVAYEGVPRGKFGDQYFSLISTYFQGRPPRSVNFHWRRFRLADIPLDDAKAFDAWLRERWYEKDALMEEYLSTGRFPASPDIESGHLETEVRLKNWFELGQIFVVVGTAGIIWRMIINAIARFASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWU0</accession>
    <name>A0A1B7XWU0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152754.1">
        <property type="nucleotide sequence ID" value="XM_018308337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWU0"/>
    <dbReference type="GeneID" id="28872444"/>
    <dbReference type="KEGG" id="chig:CH63R_13363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13363"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601153" evidence="2">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="34456" checksum="9598BCFEE98E04D8" modified="2016-11-02" version="1">MQLTKTLLFALVGTAFASPIEKRQVAIIQQAVTEVQGAITKLDTAVKGVGDDIASAQPVLAAATDVKAVITKAGNDIQGAQPLQLTEALGLQQLAGDLQTSATGLIDTIISKKPNFDKLGVSSVVLQNLQEQKSTTTSLGQALISKVPAIGQGIAQQAIDQISAVLDKGIQAYSAGGGAAPPAGGGAAAQPVAKPGNNTAAPPAAAPAKPKTPAAAPAAPKKPAAAPAAPAGGLQGLLGLLGGLGGAGGAGAGGAGAGLGGLLPALTGGAAGGAGGAGIGDALGALGALGGGAGGAGGAGGIADALGALGGAGGAGGIADALGALGGGAGGGAGAGGLGNILGGLGGLGGAKANVVEARGNVADFAEDAAAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXW0</accession>
    <name>A0A1B7XXW0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153092.1">
        <property type="nucleotide sequence ID" value="XM_018306251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXW0"/>
    <dbReference type="GeneID" id="28870358"/>
    <dbReference type="KEGG" id="chig:CH63R_11277"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11277"/>
    <dbReference type="OrthoDB" id="3497377at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601175" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="18511" checksum="AAAFB40E1B980690" modified="2016-11-02" version="1">MRLPTALLPLAAALVAAVDMAPYVPAAGVDAAFADFVEAYYLASEDQFATTSFTDFWPADNTGVLVIAGRAFPGAASILGVKQSLLPPSGDKSWWHLIRGAAVEAETAADKTFVAEIVIQTTYVGGNCSQAYGDARFTVLKDEVGSARLKPQSGSLSVYNLTVSTTDSPTDIPCSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZK5</accession>
    <name>A0A1B7XZK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M protein repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153692.1">
        <property type="nucleotide sequence ID" value="XM_018306851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZK5"/>
    <dbReference type="GeneID" id="28870958"/>
    <dbReference type="KEGG" id="chig:CH63R_11877"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11877"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="744"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="363"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="757"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="860" mass="94314" checksum="2E0E0A65F8D83816" modified="2016-11-02" version="1">MAAPAKSTRWGSFLQQAVAGVEARLDNILAEGENGSNLPQSAPASAPAPAKEQQINQPRSSTSSRTNDRLQERLAKAMAVKNNQASDARSIASDPQSARPSVDGGRPGVGMLQMDRNAPGSPVSSSALASPPAEATAPDNPTQPKPQPKSASPRCSQDYIRSQTTAKIEVQSETTSAGVTDACDTIAEPVMSETTSFQNAAGTDHQCTQCSVLRARVEALETMAGQAAKEQQEEIHRHVEQFEALQAKLQFLARDATDAARKSATAAPAGSHERKLAERDEKIAVLMEEGRNLAAMEQKHRTIIRKLRSQITGDEKTATELRARHDKLIVDMETLRTRANRVEELEQSNQALLIHSNGMQDELNALRAEVSANQSVIQRLRDDLRKASDQAHSAVAMANEEALAAEKRRVKDLEDTIAVLQVEKNLAADRAKVAAAEAEEMAVRAAERIRMVEIEMKTEIQAMEGKLEAMRALAEEASSGAVGDSQAKLLRQVETLQTQHAIAAENWQGIEASLIARVGNLERERDDALRRESEMRKKARETASRCKRQDEELQELTSKFPNHQRDIEAYKERIDALQKRADAAEAALSQAKSELEKQQQTVWKGERTDSDRRPWIEDHLSGPGSRIHSRPESPLLSVPTRTMSNDLLLLQSTSGKGRKISTPTNGTDGFQEGSSGGRRMSSQPPTRPPMQPSGSSRPVAPSITSFELPPDSLPTPTSHAGEKEDMFDGVETFSSPRMVQDMVSVSTVGAGPSVQLVERMSAAIRRLEAEKVTSREELTRISGQRDEARAEIVSLMKELESNKTASKRVAELESQVEDLNSRYQTTLELLGEKSELVDELRADVQDVKAMYRDLVERTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y028</accession>
    <name>A0A1B7Y028_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha beta hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153868.1">
        <property type="nucleotide sequence ID" value="XM_018307027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y028"/>
    <dbReference type="GeneID" id="28871134"/>
    <dbReference type="KEGG" id="chig:CH63R_12053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12053"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="551"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="679" mass="74736" checksum="3FD7977108C3B3C0" modified="2016-11-02" version="1">MGNVDHSTIRPPLPPPPPTPPFRPRRSRLGTDLAIIGVLILLSFGNIYLHAPQILGLGRHKSHSQSNDSPFGRFPLPKDPFRLIPCTNASVPPPLDDPHPEQTWAGLFDPDPSHWSWGNKTVSVERAAADPYSDRGIYLCGYLEVPLDYTNKSDDRIVRLAITKYQVSGLARVGAPVDGYKNPPPGGKSQRTIVVEPGGPGGSGTSYVWRVSEQVSKRLSNGTFDVLGWDPRGVNITQPAVACFPYDVDRDHWSLITGQYLEVSDPERQLNIADAMNDAIFKACWETHGDLGRFVGTGMVARDLEEIRKALGEDELTGYLVSYGTGIGQTYANLFPDSVGRMILDGTEYVRDHRLLGGFGWTALDNATDAWHDGFLGECINAGPDHCALAEPRDGKEPVTLKQLDRRLRSFLSSLVDRPIAGYTQESGPSLVTYSVLTAAIYSAMYNAQTWPALARMLSDLEQGNSTLAAAFLENAAWEYDPALPATPNKRPSSDELGFLVICGDSYDAPLPPDGLDWWGSLWANMTATSWLSGNSRFYDVFPCQHFTKYWPEPAGVYRGGLDHALRNPVLLIAETHDPATPLRNGRRLLAEMGRDNARLIAHHGYGHSSRDTSRCTDAIARAYILDGTLPDKAETACYADEKPYLYGVKDGGVKDMTVGGLDPVGVWREHLREMEFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y097</accession>
    <name>A0A1B7Y097_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153947.1">
        <property type="nucleotide sequence ID" value="XM_018307106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y097"/>
    <dbReference type="GeneID" id="28871213"/>
    <dbReference type="KEGG" id="chig:CH63R_12132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12132"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="540" mass="60240" checksum="38552D655E41AFCB" modified="2016-11-02" version="1">MSKTFSTSDVASHNKPEDLYIIVDGDVYDLTKFQDDHPGGKKILQRVAGKDASKQFWKYHNEGILKKYKTKLLVGSLDSKPKAAEPAPAAAPAPKKAAPKRAPESSSTESEPMDPFGDLVPYADPNWYQAYHTPYFNETHAALRAEIREWVETNVEPFVGEWDEKKEVDPSIYKQMGERGYLAGLLGVHYPTQYTKRTVASVDPKDWDLFHEMLLTDELSRAASGGFVWNVIGGFGIGCPPLVKFGQKALVERILPGILDGDKRICLAITEPDAGSDVANLTCEAKLSEDGKHFIVNGEKKWITNGIWCDYFTTAVRTGGPGMNGVSLLLIERGPGVTTRRMDCQGVWSSGTTYITFEDVKVPVENLLGKKNQGFRVIMTNFNHERIGIIIQCLRFSRVCYEESVKYANKRRTFGKKLIEHPVIRLKLAHMARQIEASYAWLENLIYQCEKMAETEAMLKLGGAIASLKAQSTVTFEFCAREASQIFGGLSYSRGGQGGKVERLYRDVRAYAIPGGSEEIMLDLSIRQSMRVHKALGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0N7</accession>
    <name>A0A1B7Y0N7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154094.1">
        <property type="nucleotide sequence ID" value="XM_018307253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0N7"/>
    <dbReference type="GeneID" id="28871360"/>
    <dbReference type="KEGG" id="chig:CH63R_12279"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12279"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="92132" checksum="717C82868FA1DACA" modified="2016-11-02" version="1">MPALTRPMAGARSGTWTPSSEPRWRGATCPTGLACEITTRNTVTGHLPRPPKTIVLLFMDVASATVVADGLGRVLVCAAHHYKGDRRRQDAVRQALQEYEDAPDAYATATATAPAGRVAPEMAAAWRLEDVPCLVGTSVIGESQDVGADAVICVQGFPIGATTLDQGFGRGARDGRPGTATCFYKQGDADDALIAPARHAGADVTADEVGMAETRESKAVVAQFLSTSQCRRVPLATYFNWASRRTRCDSLTGDLLCDLCEDRKNDGAAADTTDAEGAGRATPARPTVHRAPPTPPADPAGPRRKLPAGWQQTGGGADRRKRVRRLDRDDAAARPKKAPPQTMTPSQEAHRHHRLPGDETSARGPRSHTLAPASSRAVRKPESATLQVDYGKPGVKDYDAFRLGSARRRQLLHNKGEKQQRAMDPINSSDDEHAGLASQADQRETFNEDGLGVTGRTGRAIGASIIEEEVYEIMREGGLGSQGNPPWDATEEPDNGDGNDDNDDDDDDDNNNDDDDNIVYSRARTHARIRCAGPMQPLAQAATGSSNLRRMQPSSEVVQRSGSKLQAYNDLPYIEMLYGEEAFCIVCRVLQGCIADGHMSDECSLLEQDVGSGVKLKGALRKVLEAMKDKSVKMPNATCWKCCRPQPGPGAEDPLPRYICRGMVRGAFVCRSPGTEYHDRSRDYRGADGAGRYPSLGVAFCLLLLLQDRKRTAGVLRMLGAPTSFVACFDVGSEAAAAAAGQTGQSLDWWQDPSRLRDVVRARVRSGEGNEWKELLQRKGLCTRRNCELALFVLFVAHSLGLRARDGNRVRRWEDVVAARNSSPPLSSQMHQPVVRQREQQDAGHDWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0U9</accession>
    <name>A0A1B7Y0U9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154162.1">
        <property type="nucleotide sequence ID" value="XM_018304738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0U9"/>
    <dbReference type="GeneID" id="28868845"/>
    <dbReference type="KEGG" id="chig:CH63R_09764"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09764"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="545" mass="57830" checksum="A7EB4E8763DB687E" modified="2016-11-02" version="1">MSVNVPPGDGTTISGGGIPVPNAANANVGAAADHKEVPPQQSSGGDFDEEAADEEDAESFPKLSRWRSILLTAVISTAGLLTVLNVQSVVILLPSMSAEIGIPAARQQVVVSIYNISTGSLMLLWGRIADIYSRRLVYLAGSSLFTVSNLCLPFTKYEIPFHIVRFLQGMGAAAIIPSGIGIIASTFPRGKARNNAYVCISAVASVGSVLGNIFGGVIGSLLSWEWVFWIPAILAAVATVLAYFVTNTPHLRSSSADAAAARSGKGVDWIGGVLVSSSLVLLLAAFTQANVIGWSTPWIPPLIVGSVLLLAAFCFWQHRLEKLNDRAKEPLVRVSMFRNLQFSALFVLVGCFYASFNSFLVFVTFFYQDYLALGEIDTTLRFLPAGIAGFLISFAVSPALSRIRAFYILVLGLACSVISPFIMAVPIPPSTSYWAYGFPAMCLCLSIEVVWPVVSLLIAARLSTADQGMGSGLLQSVNNVGRALGLAIATAVQTKTQGFDEADVDTFEGSAGFLYGVRAAQWTNVGLAATALCIAVAFFRDLGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0X1</accession>
    <name>A0A1B7Y0X1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154186.1">
        <property type="nucleotide sequence ID" value="XM_018304762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0X1"/>
    <dbReference type="GeneID" id="28868869"/>
    <dbReference type="KEGG" id="chig:CH63R_09788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09788"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="528" mass="57959" checksum="2C3E552662DFFDD7" modified="2016-11-02" version="1">MGLQGVLKRAELPFVSRWINDDIRPIESQRRTWGYLMFHNFWLLVNCNITTYLTGSALIPLGLTWWQAFICIILGNVIATAVVIVNSLPGSSYHIGFPVFSRAVWGMWGSQFVIWNRILLSLDTGMTTAQFVSYIVFSVISLPVIWIRPHRLEKFFRFACSVTFVFFLVLLIWALATMGPSGFGDTITSGSALPNTGGPDSVAWLMVYGIVSTIGSIAAGILNQSDYSRFATQPKHAIVGQAISFPFYGIFSSLIGILVTAATQHRFGGEAIWNPPALFAQLLVQDETPGTRAACFFAGLCLVISQIGVNVPGNALAGGFDLAATFPKYLNIRRGAYMTAVFSVVVNPWRLVNTATTFLTVLSSYSVFLAPMTGLMISSYLIVNKKKINVDDLYRGDSTSVYWFSFGFNWRALAAWLIGVVPCMPGFIAAVDTSVTVSEGATELYHMSYLYGLLSSGLVYALLHKVFPARALDAFVRDAPSPRELQEMQKGKWDVTLAETPDILEVLPGKEGRKAHNTADVSPPKADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y153</accession>
    <name>A0A1B7Y153_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154256.1">
        <property type="nucleotide sequence ID" value="XM_018304832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y153"/>
    <dbReference type="GeneID" id="28868939"/>
    <dbReference type="KEGG" id="chig:CH63R_09858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09858"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="182" mass="20456" checksum="FD2CD6F2F3BAD8F7" modified="2016-11-02" version="1">MLRPLTLVLCGEPSERGGNRRLARIIERPDRGQIPTSEVGNSPSQRPREQPCSRHRKSLNGARGERDDRLLESRVLAFDGRSTPQLPFPPPHHYLLVGCLSLIFSSFPFLLQVGCWPSVAQQSLVGILKREDIRLTERRREKSGDLELGVRCMYLPPALTMHHRPGVGRLFGPNMPSGSQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y205</accession>
    <name>A0A1B7Y205_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl CoA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154561.1">
        <property type="nucleotide sequence ID" value="XM_018305137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y205"/>
    <dbReference type="GeneID" id="28869244"/>
    <dbReference type="KEGG" id="chig:CH63R_10163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10163"/>
    <dbReference type="OrthoDB" id="4900256at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="210" mass="23677" checksum="98531F339C3E55D8" modified="2016-11-02" version="1">MQENSGNPIEASEKARDNSDPMEEEDIPMLMSGAPAMAMFVPLEESLFEPFDAPTNEVDRLKLRQRNIEKHTAIVEQNLVYIYEREHRRILQHAKKLEASQGVHEITTGLMPGEEELIMEYVNAPVPHGADYSNRHLSTYACPELPGEMPPRQAALHWSLYNCGQALIQLAGYASHAQEIKTHYKTALERELALEKSAANKEPEGEPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2C0</accession>
    <name>A0A1B7Y2C0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154691.1">
        <property type="nucleotide sequence ID" value="XM_018305267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2C0"/>
    <dbReference type="GeneID" id="28869374"/>
    <dbReference type="KEGG" id="chig:CH63R_10293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10293"/>
    <dbReference type="OrthoDB" id="5244978at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601271" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="66465" checksum="454F434DB0761392" modified="2016-11-02" version="1">MLFSRHLLSLSLYLISTRLPPSGSSTLTLTFSTSCHWNLGFPSTRLLRYCFYSYTHLDRHSTSLPSRGKKVPGQSSRVKMSLVAVNCSTDLDDEGNDWGKAASNVPDPPKCIETCRARFLERVVPGFNKTRYPEVCNVISGSEDAKEKLWELYCCDSTFCGVQLDGNLGQDPNVNYIINHCQNLGSGTIQDPGVPPTGYVCPISSVDQSRTPCPVPFMVPDPRGPLSTRTSPMTPLAPEYTALTTLTTSTSVFTRSPTRSTHSVMNTPGISASASASNQSQIHRHGGMPMGAKVAIGASSGVAFLAMLAFIICLFRRRTRVVGHAQSLKSEIRHPNRRHAIPSPPPPVMSPSGSTHGGFRTLQTPPARLQERRLLNTPPSPRNPRINVSIPGTPLGATFGQTSPFMQFPTPSPTANKSPPGFDRSTKPYYGIPPPSVFKGTSKAGKTTSMSSSASGRTATTVSNISSSFPHLVPSSPTRPPRPHEKPLHIPNLVCPGPPPTRSLPSPPPRSPSSPLSMFRAQQRVKSSSSGGGALGAAIENGWVPPRNPARGVVLGKESKDLRDLTETCARESQERDSWGSWSIGVGGTGVGTGSIQKRGGSVNSPVLEEADLERLGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y303</accession>
    <name>A0A1B7Y303_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Isotrichodermin C-15 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154918.1">
        <property type="nucleotide sequence ID" value="XM_018305494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y303"/>
    <dbReference type="GeneID" id="28869601"/>
    <dbReference type="KEGG" id="chig:CH63R_10520"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10520"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="491" mass="55580" checksum="BA01DFB525203CF7" modified="2016-11-02" version="1">MAAILTFLWENSTRIVAVALGGALLWQLLLAGYNIALHPLRKYPGPVLQRASPFVWAWQHAFGYQAFSTQRLHDRYGPVVRISPNHLSFTNVEAWKDIYGFQIGKDFEDNEIPKARLFSTTIEEIPTSIVNADREEHQRFRRALSHGFSDSSMRAQEGIIVKYIDKLISRLQKNSDRGKKALNIEAWYNWTTFDIAGDLIFGQSFKCLERSDYHPWIAFILQTIRYNAFMTALKYIGLDPVVQGLFKMGSLSAMAKLQESTHEMMETRLNMVQDRKDLFEAFPSRASRKLTTHAWTKNLSFEKLSANGLILVLAGSETTATTLAGATYLLARNPDVLRKLNNEVRSAFADQSEINIGSVSKLAYMLAVLNEALRLYPPVTSGLIREIPNGGCQIASEFVPKGTFVEVQQWSANHSPDNWTRPWEFRPERFLEGGKGEHNHLDALQAFSLGPRNCIGKKYELPVGPLVLKKSTNEMRFADKKPGCQHQPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y341</accession>
    <name>A0A1B7Y341_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154965.1">
        <property type="nucleotide sequence ID" value="XM_018305541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y341"/>
    <dbReference type="GeneID" id="28869648"/>
    <dbReference type="KEGG" id="chig:CH63R_10567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10567"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="469" mass="52254" checksum="8049355B0EA40E8A" modified="2016-11-02" version="1">MSVKNVHDASTAIHPETHDELRTVKRANKDDIVPDDATTLSDSELAREAALTALTVEEEKKLIRKVDWRLIPLLAMLYLVKKLDESNVSQARIMNKGTERNILTQLDVTSDQYGMVTVLYTVPYILAEIPSNLLLKRFKPSRWQSRIMLSWGIVTACTAAVHNLGGLYACRFLLGLTEAGMFPGIILQLSYWYRPDEIAVRLMWIFPGNTKWLSPVESAFLQARLPPNSPRSSEKNFAGSEIIASLKDKRLWLFTLSWAMMTCGKNGIDFYRPSIIANMGFSDIATAQVLNIPTSAVAIFLILSLGTWSNKAKIPLPLFPIGCTVVIVAMYSILVVYPNDIGVYIGMMIGVACGTAWFPLMWPWRAQTVNGATGSAFAIGFVNSYGQVGDALGPQMFQEKYAPSYQLPFGLSMGLVGLCGIVNGVTWWVTRRTENDTRRHKRARILAKKNNEAVLDDVVDLDLGRKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3U7</accession>
    <name>A0A1B7Y3U7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">H+-pantothenate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155192.1">
        <property type="nucleotide sequence ID" value="XM_018305768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3U7"/>
    <dbReference type="GeneID" id="28869875"/>
    <dbReference type="KEGG" id="chig:CH63R_10794"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10794"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="189" mass="21081" checksum="7CA589988420ECC9" modified="2016-11-02" version="1">MLYSLSVQAIGNNVIPLWMASRGYSVIQQNNYPTATYATGIVATFIYCAVSDKLRSRWQASLCIGFTFVVSSAILISDPPDAGYFFAFYLMGTTYAPQALWYSWMADLTAHDVQLRAITTGFMNSFDFAFVTWWPLIFYPVTDAPNYRKGYIASLVTGALTVPVILLIAFLERRGRGKGTIADVNDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y534</accession>
    <name>A0A1B7Y534_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_08680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155677.1">
        <property type="nucleotide sequence ID" value="XM_018303654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867761"/>
    <dbReference type="KEGG" id="chig:CH63R_08680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08680"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="893"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2062"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2068"/>
            <end position="2081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2091" mass="228463" checksum="1355D1095E357E42" modified="2016-11-02" version="1">MATIFQSFRSSTLSKRLLIYALRRLELLDEETLDMENLQFALGRTTTAEFKDVGVRLKKLERLLQLPTSFQIQKAKVLKLNVTVPVDFYTSPIIIEIDGVDVRLKVSTAGEDNKSKAAATAAATSNEDESKGLPNTINLAESFLNEDAALKDTKLADEKRRLEDALAAETQDLGGSTLSESSTSDDGSQFGTGQALSLPGFLAGFLQGIVDRIQVRIRGVTFQLDVEVPVEPNSTTPELVTFQLALDRIDVEGVTAEAHDDEGAPTIVPKDGKRHIALCKIRAYLISEANVFSQFARSSSVSSPAVSQSPSFSERASASRHSSFRPTMQDSYLSDSADLSEVDDALLQDSEDAFNIPYDFSSQTEEPVEEEEANTPRASIYQDFSPRGHFPMSQSTVVGDDDRAAPWASFQREARSEPSLQPIEGMQTADLLDFGTPEASQHSSATGHSSSPGAGEDLAQSHLFTHEEAESMYMSAFSQAEPQPEGPRMPGGWDADPSPEASPQVKKASPVPRKPSPPAFEAAPDIPESATPKYHDAPASPRPKTPPSKIESSEPSFEDAREPKQSPPRIPEEDEPRDHLADTPAQADDVATPRGPTRLVKELVSLQNISLYVPSLHQHQHVHAPLDAQASVLSHNAASTGLARSVAPQVPGAFSVYSTSPGMRSSFVPRSPGLAMTEPDSDGPLEVQISPLEIRFDASLAYLLAVVVGKLLDALKGNAGSTPTPKTTGTAKGQQESTIPDIKVVFEKISLHFLHQLGGVADTAERILGSPRLQLQPEILLRTDLDNLSVSLKNSKKSIETTVDLEKFRFGYAKDDIISFDQSLQMRASVMDKFPSAGSDISVKVIKLSDSIRTEVTTLPLLVQLDLQRLDETFSWFGGLSSFLNMSSSMSSSASPSVRSPVPPPPKPRGVRFDAPINPDDKSASAENKIDMRIGGFNLELKGKECSVGLETSAVKMVSRELGIGFAISKVRLAGPYMRYSRGEPPISADIGGVRFEYLATPKDKDLERLLELIIPSKAKFDQGDDEIMVDTLLRQRRKGGVLRVTFDQFSVRVDRMDQLNCLPVLGDEVARLATVAKYLPEDDRPGILLLAEVKELAAVVDFGGKLGVLNANLRNFEVAQITVPSLVAFGVHAISVNRNHREDLVSSSTTLPPGTLTQGPVLMVRMIGDEMEPVIKIKMRDVTIDYRVPTIMDVLGLADDATPQDFEASLAASVANFGEQAHTALAGKKSQTTTRLPDPARPNSKPMTVDLVLRDCLIGLNPLNLPSKLLIALTDARFQVVLPKDVDTTASLDLNKASILLIDDVANVGASSTVNRRQSADMSSQQVSRLVSQGFVSICYISSAKAVVKVSETPEDGEKHVDIELRDDLLVLETCADSTQTLITLANALTPPTPPSKENKYRTSVVPVQDLLASISEEAFGKAEGDYDFDKDFELAQELGGSDEYDVASDSSPLQIDSRYYGDAGGPSEPLFDAEGSITSNATTTQDTHDGVLLTSFNASASHHSDDSSDLVIHEHFFDKGPETDGRAQVWNSSKNSYDRAPKELVRRSPLRVSVRDVHVIWNLFDGYDWERTRDVISKAVQDVENKAYERRRRSDRAVFEDDAEEDETVIGDFLFNSIYIGISTKQDPRELAQMVNQELNDNATETESLATTAFTTTTSRAGGSRPKKRLRLNRSKHHKITFELQGVNVDLIAFPPESGETQSSIDVRIQTLDVFDHVPTSTWKKFATYDQDAGEREMGTSMVHLELLNVKPQLDLAASEMVLRVTVLPLRLHVDQDALDFITRFFEFKDDSAPVHSSTSDVPFLQRVEVHDIPVKLDFKPKRVDYAGLKSGRTTEFMNFIILDEARMTLRHTIIYGVSGFDRMGKILNDIWMPDVKGTQLAGVLAGLAPVRGIVNIGSGFKELIEVPMREYKKDGRIVRSIGKGAAAFARTTGTEMVKFGAKLAIGTQYALQGAEGLLNKPQADNTWEEADLDPEEKKQISLYAEQPTGVIQGLRGGYSSLTRDLNMARDAIIAVPGEVMDSQSAQGLAKAVWKRAPTIIFRPAIGATKVIGQTLMGATNSLDPQNRRRAEEVSDKRINPPLNEMKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y557</accession>
    <name>A0A1B7Y557_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_08710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155707.1">
        <property type="nucleotide sequence ID" value="XM_018303684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y557"/>
    <dbReference type="GeneID" id="28867791"/>
    <dbReference type="KEGG" id="chig:CH63R_08710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08710"/>
    <dbReference type="OrthoDB" id="2093493at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22849">
        <property type="entry name" value="NuzM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016813">
        <property type="entry name" value="NADH_Ub_cplx-1_21kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37325:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G05910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="55"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR07189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="51250" checksum="1548F532FF06D5B2" modified="2016-11-02" version="1">MPVELRKRKAPEPAPAPAPKKASSKVTKAAEKVKGAVKGNAEKPVETVVDEPAEKPTAANGSDKKVKAVKGETIDLDGFGGEIETNEGDKTTLKELVDKSKAGVVLFTYPKASTPGCTKQACLFRDSYEPLTKTGFAIYGLSTDSPKANTTFKEKQKLPYPLLCDPKATLIGAIGLKKAPKSTQRGVFVVDKAGKVLIAEPGSPAGTVEVVTALVEGGDVEAAADAAAVDAKAEEPANGETKTAEEKKEDAAEKKDGKDERRNAHIPSSSWSSNRCQSNRPQIFLPPSTTSPNMASKAVAKAAASGVVEISKKHTLQSQGVWERIRRSLALDPNRSSGVPLNPTFRNPTPGAYDPLSYDDPVTLPAGDIADNPYWKRDARRNYPALSVVNQADVVGLLSVGSAASPRVELIGEAGEKQLVAAREEAAATGLAPYLEKNAAKAVEASKEALFTNGLPPTPSGQDLKSGTWNVHKYEVNKDQSYGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5U9</accession>
    <name>A0A1B7Y5U9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C-x8-c-x5-c-x3-h type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155874.1">
        <property type="nucleotide sequence ID" value="XM_018303851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867958"/>
    <dbReference type="KEGG" id="chig:CH63R_08877"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08877"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1486"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1486"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="951"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1249"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1267"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1339"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1432"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1512" mass="166920" checksum="C38346F8B72CAF8B" modified="2016-11-02" version="1">MQNWQPNGQAGSPQGHNNMWSSGYTFPDGANQFDASQNWQHHQLPNQNAFSHLGARGNGAENNLYTSPHQAHATVATEHSSMSALNHGSFHNGHSQFPLDTPYTDAGQEDALAGLNDFPQDMYGEPGKADFSANIDNLNHGHTPDFTQQQFQYNGQANQLFNGGVSQYTDAQLIPQHGHQTPAQLQQRFDSVSQSFSPAPQGYVPSPQPQQHQAQPERVFSQSPHSFQAQQSHQQSSQGFSNPTPPPFQQNQTAPYQQHKFVPQQVSYPQPGGRSAFQPVAAKQMPDQDSTPQHTPQPIPQQQSTHQVKAVASPARTVQSQQPQKQQPHLQPIAAAPTSQPGTPAIDPALQPEPLKKRKRVLKKEGEAEQVDSPNSKRADDGETLALPSSVEEEMVAMEKFRKRSAASKKQFPPIPGAPFLVSSGTVKLAAPKSYDRLAPLVALPSSSGRRILPELGRDLPCEIQGRFTDKYRPSVNFVGQPGDRETEAKALIEQYGREMGDLKSGRPKYSEFPFTFQEQLKADEAAKSKAQRKARKEEEEERKRPIRPETRPTDPVEAAVWDVLGIAYIDPSATRTTALLGTTVQALGEFLVKLRSELNRLRQEVDQASKEGKPPSVMAEWNSKLDLKREIFTRVCDAAAKHGDEAVLENLGGHQKGVLSLVNMLIGCIKAADFKGPLPKALLRLMSNISIHKKIADAVNFETIRKRFTDRGDDEIKELVRTIASRIKKDAEPINGLDAKKAPSTAAVSKTPKPAAKPLDGPSAKRVRDDDSDSRNVKKMAIESTNTASGTKPAAKPAAGSLQSKFGATKPRPAASTSLAGKIRAPAPKSGTRDTAKPEPSRFEASASSAMDVDKKPATSAPKPEAKVPLAKAATTSGIASSSIASLLDSINTPKADGGPSAQAKDSSKNDISETPEEKEKRLRKEARRKLRVSWKPESELVQVRIFHKEAAEDQDNMTKDAADDRSEGMMLKQRTYNEDDDEEDDLPQKPWARPTFADLSSIPMDYRNKSFITRGGNLTFHTEEQRTTEEREKKELMVTYMDISDIPPTPKSPPPESATLSSQGKTCQLPQGEPKYDEIHKRWKEAQQFGWEAAGYYARQRLDAQDDPATKLNSILGNLKPIAPAVEPEPYNMTPPKENAQPILPHATDMQPVPVIPFDDKVHDILISDKMKNWQDPSPFNLAAQQTHRRYDYPDPALQAAADDVEEASEALKGLPYPATNPPAWLANNQERVREWWAGYQKDLAARTKKGAGDQAQAGPSVEVEPQQQQQQQQQQEQEQGQQQPAPQAQEHSDAWAAYYKQQEQQYAQYMAMLQGSQPQQQLQSVPPAQPTPAAPAPAGDSQLQTLLAQMAQQQPASQGVAYGLNPQDTGYQQLMMLAQLQQQQQQQQQQQQQQQHTPPPPPPTASQSPPNHEQNSFKPPHLQRQLVDYSDRDTRDEFEQLSGRDKERGREREGKGGKQGKNRKGNAPGGATLPPHRPVNRALIGTKPCSFWQQGKCARGDKCTFRHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6M1</accession>
    <name>A0A1B7Y6M1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_09168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156165.1">
        <property type="nucleotide sequence ID" value="XM_018304142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6M1"/>
    <dbReference type="GeneID" id="28868249"/>
    <dbReference type="KEGG" id="chig:CH63R_09168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09168"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601378" evidence="9">
        <location>
            <begin position="23"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="225"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR07647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="53678" checksum="12F90CA711F1CED4" modified="2016-11-02" version="1">MLFSHFGRAALAAATFTTPSLAQTSNPPDLGQSTFVAPENNVAFGFTVPENSGEDVFVTIRAPIDRTWAAIGIGQDRMPGSLIFMIYRDETGNGVTFSPRVAYGNYEPTYYDHMKWEVLPGTGVFNGSMFFSARCTDHCRSWPGGWVDVSNENQKAIYAVGPKGGFFSNKMDTSVKFHEEFGRFTINMKRTIGPADAPVLKADSVNEGTNQISANDERRDYKSIFHAILMVGSLVFLIPFGAVLLRFGNMVRWHALNQGFALLIVIVGFVLGVLSSFWYTRVSRGRPCYDSWNANAVVGQSRGFKSPHQIIGFIVVAFLLAQFAIGFLHHQKYKKTHQSTPYKTVHIWLGRIVIALGTFNAFLGFSFALNRKYNYFLAAFIILMLLVSLFITFGGKWVRGRIPAKFGSQAQGGYNPEPWRQVPTQGGFAYGGAPPAYQPPSHQSQTIGLTSMVADPTQPTKERSGSRDYRNNDLGSTQQPREMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7N4</accession>
    <name>A0A1B7Y7N4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156590.1">
        <property type="nucleotide sequence ID" value="XM_018304567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7N4"/>
    <dbReference type="GeneID" id="28868674"/>
    <dbReference type="KEGG" id="chig:CH63R_09593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09593"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25182" checksum="B5DEFB69A660E081" modified="2016-11-02" version="1">MPPSRSNILSWLATVPSDEEQQRRGPPSPGPPATRQLPLPDPLPLLAGPTYASTSESTNHVFQGTSFGIPTRPSPALGRLISRIHDFADGLGVIARSEERYEGQWNNFVRCPLLCMALGHSRVIGVSNCYKKRHNLLSTLNVFLFLLEASASRPRQNSDWMQARKMEHVAVLVAAPSLPLTRSLDLALSGIYCGISVSAKVDELECMRLCLVNGAEGPNTDQLMVAVVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7S9</accession>
    <name>A0A1B7Y7S9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156543.1">
        <property type="nucleotide sequence ID" value="XM_018304520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7S9"/>
    <dbReference type="GeneID" id="28868627"/>
    <dbReference type="KEGG" id="chig:CH63R_09546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09546"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="342" mass="35975" checksum="228DB4CC4AF082B0" modified="2016-11-02" version="1">MRAWLYDSVSGGLETHLSLVDDAPQPPSLGPNDILIKVHAMSPNPADYKFPEGLGMLWRLAVSLPATPGSDFSGTVAGLGDMVKEVGEFTIGQPVYGCTPPPTRHGSLGEYVVATMASCAPVPSPAGALTLESAACLGVAAQTAYQAISPHVAPGDMVFINGGSGGVGTFAIQIARVLGCRVVTSCSGRNAELCRSLGADEVLDYTEVDVSKALRAKGPVFKLALDNIGLEPADLYKAADEYLMPAGRFVQVGAGLSLRHMMSTAGRALRPAGLGGGKRKWQFMSLQSKHADLAKLGRWAAEGQIRAVVEETYRFEDAPKAYEKMRTGRTKGCLVVKGPDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7X3</accession>
    <name>A0A1B7Y7X3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156546.1">
        <property type="nucleotide sequence ID" value="XM_018304523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7X3"/>
    <dbReference type="GeneID" id="28868630"/>
    <dbReference type="KEGG" id="chig:CH63R_09549"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09549"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="94" mass="10414" checksum="5A2E02BD0DF215F8" modified="2016-11-02" version="1">MDVFSWRGGYLRFHPNKGSFGRRKGVREKNKSCLCNHKLFFQFEQFMRRKGVAGGSAQALWLVWASLATVGLHRLSCGATGGSRGLGYTFPGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8K1</accession>
    <name>A0A1B7Y8K1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156796.1">
        <property type="nucleotide sequence ID" value="XM_018302018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8K1"/>
    <dbReference type="GeneID" id="28866125"/>
    <dbReference type="KEGG" id="chig:CH63R_07043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07043"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="270" mass="29247" checksum="A4F88279B6641480" modified="2016-11-02" version="1">MSTANGSAPNGAAAKKPNGKQEIKILMLHGYTQSGPLFRSKTRALEKLIAKSLGPFNIAPTLTYPTGPSKLSPRDIPGFVPDESGGDQDQDIDAWSWWRKDEASGSYRFLAEGVSAVADAVREAGGDVDGVLGFSQGGAFAALLAAMLETPHRDEAKIPEDLRSAVRALREANGGRPFKFAVIYSGFFAPPDELRWAYEPRITTPTLHFLGSLDTVVEESRSRGLVDRCEDPLVVVHPGGHYVPITKEWAMPLIGFIKKIADEEKAKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y915</accession>
    <name>A0A1B7Y915_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157067.1">
        <property type="nucleotide sequence ID" value="XM_018302289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y915"/>
    <dbReference type="GeneID" id="28866396"/>
    <dbReference type="KEGG" id="chig:CH63R_07314"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07314"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50279" checksum="403B1F59E15DA152" modified="2016-11-02" version="1">MAPLILHNVPDEELYVGDDGIKRPYAMVFPQQEGLPGARNRRGVAETGSFGKSTRRSRSRTGTPAGRRENPTVAAADKIFGDWLSTQAVTNNNVAASTTATTTTTGGAGGNSSAAAVVPQRKTSGLSQAPLLASAADDTPAAAEPRVTRHVPTEIILRGYRSPSQQYAAISHYEQLAGLICEDYPREPPLEQRRYKSELRDPAFTRRRGLTAEERAKVNRADGGEHWVKVTFESADAADAAVYASPQRVLGYLVHAEPYHGLPPARDEPVPDVDSLVAAHEEHGRSRSVPAGSFGTHRTPRGQHRSASKNGGGNPFSIPNTRSTSDLSPPTSLTSSNTIETATISNTTNSSATLTELQQQQQQPLMQAEDSMFCRRIPTARKARLLPAEQALLPQQSYTQRVVNMVPFLKWFSGSMIGNEVPRTDSGDFDWNRASLYWKIIWWLDATFGLFGGEILSADKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y982</accession>
    <name>A0A1B7Y982_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP12 chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_07416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157169.1">
        <property type="nucleotide sequence ID" value="XM_018302391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y982"/>
    <dbReference type="GeneID" id="28866498"/>
    <dbReference type="KEGG" id="chig:CH63R_07416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07416"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="426" mass="46559" checksum="E80A1CEDC2AB0D21" modified="2016-11-02" version="1">MIFFGGACREAPKNKSTSTCALQLQQLFRIHLQPPFYNSRAGADTEMKTSTRIPLRLFTASSPLTTTASRPRFAAAARAISTTTLKPAEVAPVVGTGPPPEAPVPDVASEERAAVARARLERRQRQAEMLKHAKSIRTSAEAKASKPGALKRRFWNDVSVQEVDGALQVHLDSRPLRHPNTKAIMRLPPSKQYLASALAIEWDMITSAQQATKQHMIPLTSLTCRALDIAEDDAAAGAIRETIATTLMRYLDTDSLLCWAPPAGPMDVPNDAGESLRDVQKRTTEEVVGFLMARVWPGIEIRPVLDENSIMPIAQAEGVREVVQGWIMGLDAWELAGLERAVLAGKSLITAVRLVVEWSEGPVGDHREAKSPRKFGIEEAATAASLEVSWQTGSWGEVEDTHDVEKEDLRRQLGSVVLLVSGTNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9W0</accession>
    <name>A0A1B7Y9W0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157391.1">
        <property type="nucleotide sequence ID" value="XM_018302613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9W0"/>
    <dbReference type="GeneID" id="28866720"/>
    <dbReference type="KEGG" id="chig:CH63R_07638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07638"/>
    <dbReference type="OrthoDB" id="4851670at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601460" evidence="2">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="55350" checksum="5AB9CB9B49D575FA" modified="2016-11-02" version="1">MRDTAAVVSSLLLALAGSLAAAESLITLHGASASATASGVAASVSVSASASASTSRASTTRSLPPIGREPNCSRSVRRFRVPPTLPTLSEATTTYHTHSASNATHTLALTATPTSPTLTITSSSLSSVASRSAVQPVPRDLEHDDDKKTKRKTRTPELWPVIPRPTVFIPEEEDKDKNKDKEMMHGADEKETSTRRTRKTRTPELWPVIPRPTVFIPEEEDKDKKKKDKEMRVEAAPTVAATVSVSRTAGVPRPPRTAGVPRPPRGPKMIRPAKMLRAKNPRGPKMPQGTEAAAASSSAIPDYQTDATLASRDLPAAQSTEATTHSSSSSSSRCTRTQRPSCWWKTGSAKSSSSSGSITGSSTASQSTTSAPTTSGNGPNIRTITVRPATTSTLVTSTVSVSGSSPSSCPYPSTTAGANVVTVTVTAEPSYVPTYYLNPSTDQRGFRGPEGLEDAQPAAASSFTYTGWLGPTTDHRGFRGPEGLEEPQPAVTSSFSYTGWLGPTTDHRGFRGPDGLEDVPPAVTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA79</accession>
    <name>A0A1B7YA79_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157373.1">
        <property type="nucleotide sequence ID" value="XM_018302595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA79"/>
    <dbReference type="GeneID" id="28866702"/>
    <dbReference type="KEGG" id="chig:CH63R_07620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07620"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601467" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="401"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1018" mass="110814" checksum="0E9D0A70A6495E48" modified="2016-11-02" version="1">MRLGLKAGAGLLWLAASLCGGSHGASAQEVDWPIHDNGLNQVVQWDHHSYIVNGERLFVFSGEPTSYPQTPYKTPTLTPTPSKRPELWRDLLEKVKAAGFNAFSIYNHWGYHNPTPGVLDFDTGAHNFTSIMTVAKELGIYLIIRPGPYVNAETNAGGFPLWLTTGEYGSLRNDDPRYTEAWTPYWSEISKIITPHLVTNGGNVLMFQIENELNGQWKNIPNRVLNPPIANYMQLLQDSARENGIDVPLAHNAPNMRGFSWSKDFSNATGNVDVVGVDSYPSCWSCNLSECTGTNGQYTPYPNFLPEFQGGSYNPWGGPEGGCPGDIGADFANIFYRDLIYQRVTAISLYMMFGGTNWGWLACPVVASSYDYSSPVSENRIIGSKFYETKLLTLFTRVAKDLTKTERVGNGTGYTTNAAISTSELRNVDNDAAFYVVRHAYTPSNTNEAFKLSVKTSQGSFTIPQHGSSIAINGHQAKVLVTDFAFGDKTLLYSTAEVLSYIVADGREVIALWLPEGEAGEFTVTGVTSAEVVGEANVADFAAYPGEANVTVAYTQKKGITLVDLGDGSRAVLLDRTAAYLFWVPTLDNDPFAPANNTVFVQGPYLVRSASFNETGRGLDLRGDADKETTITVFASASLCSLTWNGKKLEILSRDGNTFTARIDGPPKFELPALGPWKVHDSLPEIATDYEATSDSWVVADKNTTFNSVKPAANNPVLYVDEYEIHVGNHIYRATFPTTDDAPTGVFLNVTGGLAFGYSVWLNSHYLGSYLGLSYLGADARDFSFANATLADAGAGDNVLVVVMDNSGHDLREAALAPRGISNATLLGPAAQDYKFSEWKIAGTAGRNDLVDTVRGPINEGGLSAERVGAHLPGYPDSDWESFASDGGALSVPDAGIRIFRTVVPLDVPAGLDVSVSFRFSAAQDDTNRLRALLFVNGYQYGRFNPYIGNQVHFPVPTGILDYAGDNTIAVAIWSQAAEGVALKVEWQVDYVHTSSFDMTFDTKPLRPDWDESRLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBE0</accession>
    <name>A0A1B7YBE0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157928.1">
        <property type="nucleotide sequence ID" value="XM_018303150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBE0"/>
    <dbReference type="GeneID" id="28867257"/>
    <dbReference type="KEGG" id="chig:CH63R_08176"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08176"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="457"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="539" mass="59699" checksum="9908339939A4B1E3" modified="2016-11-02" version="1">MARYNNDVRAWAEFPLLDPTVVIAIASEVDLHDASQLGEVRGMLQTLAQNVLVEEASGFNASGVPDTSGSIDGAADAQDGSTNTTEGLQPKDSDSFRTALTSPPPSEPDYDVPRIKTFDGDSDQEKALQLQEMFSDLKMHDVNFALKKAQGDFQTALETLLNIQFLESIGERPKGIDGFFQSEISQKPSGKRKGKGKKRRDLRTDLSSSSSSTPEASPVNVDNERIERILFIVEKLELPFEEVSDVFDAHKGSMELTIIEFLDRYIKQGVGVWTAEDDYRKQRVQELKKQYRHIPEHYLPPLDEVTRGDHQWTEEVAVLLNRYFGKLPAKRLEISYKLAPLTSTELEGSSEGWQKVPSPKTSVMSPTGHTLSTPALSGHLSTTPLSYRQAMDTASVYREASNHSYSSAGQVYKKGHLYRQAAGYYAERGREEARSFAKAKSVAADIHVASTSSANEIDLHGVEVADGVRIARERVWDWWNNLGEYRARKAQEGFTIVTGRGLHSAGGVSRLRQGVIAALVNDGWKVSIGTGSYRVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBF1</accession>
    <name>A0A1B7YBF1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157923.1">
        <property type="nucleotide sequence ID" value="XM_018303145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBF1"/>
    <dbReference type="GeneID" id="28867252"/>
    <dbReference type="KEGG" id="chig:CH63R_08171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08171"/>
    <dbReference type="OrthoDB" id="4777753at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32952" checksum="398B44F78F794ACB" modified="2016-11-02" version="1">MPRESSKGDPRITFKKVHSLNRIGDRAPTRTQRQLAANVEPKKHSQHLPVHIHVHKSKQPEGKRDDTLPGGDGVGGTASSQVTPFWGIVSPPRSSPPFHFEITLSGRDADFVVTNGRESLEGSLESARCGSCGHFGHRLIDCIFMDKNGFVSGCPLCNDKRHRWDDCKRKHELSERDVYHVVVQRRGNKPAIASSQPWIQLVARAQLKMFRVRGSTTGPFPWTAKLAQSIRNGNFRTKKSVMPVLFHVWYNYRDDEGSGPRNRFLVSDPVTSSLRAVGVNAKRLMKLEVCSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCZ4</accession>
    <name>A0A1B7YCZ4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_05631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158456.1">
        <property type="nucleotide sequence ID" value="XM_018300606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCZ4"/>
    <dbReference type="GeneID" id="28864713"/>
    <dbReference type="KEGG" id="chig:CH63R_05631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05631"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="117"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="627" mass="66913" checksum="4434B0046AB1F9B0" modified="2016-11-02" version="1">MTQRQLREVHDDEKLDDIERAAAASQTERGSTKTTTTTSTDSQTIRSNHDGADDMNLGTAKSGAHPGDATAAAGGDTTAETKEASGDHAPTTVTATAAAAADDDPEAGRTKLETLLIVLSLCAALFLAALDVTIITTAVPTIAEEFNSNIGYIWIGSAYLLANAAFVPTWGKISDIWGRKPVLLSAVGVFWIGSLICGLATSMGMLIGARAIQGIGGGGIIVLVNICISDLFSMRQRGVYFGVMGMVWAVASAVGPVVGGVFTSQVTWRWCFYINLPISGVGIVVLFFVLKLHNPRTPALEGLRAIDWIGTLTIIGGTLMFLFGLEFGGVSHPWTSPTVVCLIVFGIVTIALFAVNEARYARYPVIPMHLFRSWSNAAAFATAFCHAFAFISGSYWLPLYFQGVQGVSSLLSGVYLLPYVLSLSLMSAVAGVLIRKTGNYLYLIIGGMFVATLGFGLFYDLPPDRNFVKIVLYQMVAGLGIGPNFQSPLIALQTSVEPRDIAAATSAFGFVRQMGTSISVVIGGVVFNNEMQKQNPRLRERLGPDLADMLSGSSAASSVGVVANLRGEEGRIARGAYLTSLRTMYIVYVAFAGLGLVMSLFIRQKKLSNKHTEHKTGLKTLRSRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCZ7</accession>
    <name>A0A1B7YCZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158245.1">
        <property type="nucleotide sequence ID" value="XM_018300395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCZ7"/>
    <dbReference type="GeneID" id="28864502"/>
    <dbReference type="KEGG" id="chig:CH63R_05420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05420"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="296" mass="31299" checksum="9DE57B8888A52440" modified="2016-11-02" version="1">MNKSAASLPASYAALEYDGLAVSHVPPSSSAVTKVVVITLNRPHKYNAVTLDMLDGLEALFNTISEDPRVRAVVLTGEGKAFSAGADLDVGGGRVALAITNCKKPAVVAVNGAAVGIGLTMTLPATIRVAWEGARCGLPFSRRGLVLESCSAFFLPRLIGLSRASHVVATGDVYAVTDPLVGGLFSKLLPSPAETVRYAIGLAGELAAKTSLVSTKLMRDMLLRCPASPEGAHVLDSRVFLQLAGTADNVEGVTSFLEKREPNFTDTVSRESVPFWPWWDGDMGRYVTQLEKAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDP1</accession>
    <name>A0A1B7YDP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158694.1">
        <property type="nucleotide sequence ID" value="XM_018300844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDP1"/>
    <dbReference type="GeneID" id="28864951"/>
    <dbReference type="KEGG" id="chig:CH63R_05869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05869"/>
    <dbReference type="OrthoDB" id="4072826at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="225" mass="25019" checksum="6C2C6E1E406284F8" modified="2016-11-02" version="1">MTDVQPLDFVTVKAVLPTIPLPPHASRQPIVTERLVLRPISPDDLQPLHVLRTQPEVMRWSAAGRVDADVDETWAKLAQCLPPNDADNYDFSICLRSTGEWIGIGGCKHLSGGELGWPEIGYMLRKDFWGSGYATEFVQAFLDAWWSLPRSERELSVDRATVRGWSGGEAAVDEIMTAVTEPDNVASQKILGKWGFRKLKVWKETSEDGGKETILIGHGIGRPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE61</accession>
    <name>A0A1B7YE61_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA synthetase class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158873.1">
        <property type="nucleotide sequence ID" value="XM_018301023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE61"/>
    <dbReference type="GeneID" id="28865130"/>
    <dbReference type="KEGG" id="chig:CH63R_06048"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06048"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="202"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="715" mass="80014" checksum="697BF8764284ED8B" modified="2016-11-02" version="1">MLRQCCRTRALAALHPRTPQSQPLSRVASLLYRHECSALLSPSRPVRSLSTTQAKKEVQDGSWRTQLSGEFKECFALPQMSPVEAWSKPGSQIVVSGHIGRTRKVGKNLAFAHLERNGERLGQICAKGENAAILAKIRPFSAILAKGVVTEASGAARFEMDMESIQYLNPFPKDIIIGPDSLFPPEHRHLQLRFHEDLRDRLRFRAQLKSTMGQAMVDRDFMDVETPILFKSTAEGAREFIVPTRRPRHAYALPQSPQQYKQVLMASGMGGYYQFARCFRDEDHRSDRQPEFTQLDMEKSFATGKTIMEDVEYVVGRAWDAVREQYVMKLGEDSFAPVRKASLQDWKQSVEDSAKDDAKGPIHQEYPTISTPFLRMKYTDCMDLYGSDKPDLRIPNRICRVDEHLNEGFVSMITDLKAPIVEVWKISPHEDADKRDVWKFVAGFMESLPKSLSQNPDGAPTALMFDSSKPLNGFSALGPEGLDSILGALPEESGFSSLENGDIILFQARKNQPQQGGSTKLGETRIALYHAAVEAGLLDRDDSFKFLWVTDFPMFTPEEEGDVGQGGASGFSATHHPFTSPHSEEDFELLFKDPLRARADHYDLVLNGVELGGGSRRIHIAEIQEFIFRDILKMSQDKIKEFSHLLKALRAGCPPHAGFAIGFDRFVAVLSGASSVRDVIAFPKNNNGVDEFAGGPGKISKQQLDTYHLQFRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEE6</accession>
    <name>A0A1B7YEE6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158922.1">
        <property type="nucleotide sequence ID" value="XM_018301072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEE6"/>
    <dbReference type="GeneID" id="28865179"/>
    <dbReference type="KEGG" id="chig:CH63R_06097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06097"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="860" mass="95439" checksum="2E60AD178E96159C" modified="2016-11-02" version="1">MASTPADAEVRRRKPIRPSKTFPMTSLPPQTVDDVPLSNRGPDYLRIPPAVSGETDDETLSGQSQHRRSESINKNDIQDQDNVSLLPTEQSKHSTTDSATATPSVHDDRGRTVTHWSMYSGGWIIHLLAVSMTIVVLVIGMKKIYWYPEAGPLIHGDYRLDAETISNVLQLVAKIHELLIVASLSSIALAMFRHRLITNGVRLGFLTGSYRVGDVGYLGTAAFWRQGLDIQGPWEILLSGFLVFATIMSTVVGPASAVLLLPTLDWYEFNPGTQFENIKLPLWYGRYPNSTWTENYWGADSLEDAGCDTVNGIYTTGCPAGGFNGISTWVQNHGATQLENNLTFSSTSADIRRHVVFAQANFSEDTANTTLSTTAPQFILDSIGLFQRYINAKNRTVGAVSREPHYRLNFTRPEKISDSSVAELYQPFVQSRCEVHDRDQILNTDIAYPNSANHFQCFNQTECLDISEHLPVFKDTRRDSDNINIDRLVASSAVTNYWTINGSSSVIFLRGLMPNKTLENGNQTQIAYLCTLTANWVPSNFSTDPGVSDVLHSTLSDENRMKNVYHNISVQGVLPMRFNSSWFKHANPSWNSTKNTTALARVVKYFARQERQNGSIQGYMALGDSSNKAAIEGLLAKVFGGYLTDALARSSFGGRTIVRLPDTDWKFVDLVQQYGDRGGIHKYTPHSHNHNITLDQWGELTNEINGSFHEVVERFESFLAIDIQAERYGYGTGQQRKTASFAQAMLFIYLGAIAIYSATITIYSATIVVSKEPEYLEGGKPGGRRRSVIPWADMQDLFVLGLRTTPPGGDDLATSGVGVSDIRIWQKVVAARAGNDNKVQLAFQGSSLKELKPSNAREYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEP0</accession>
    <name>A0A1B7YEP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_06245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159070.1">
        <property type="nucleotide sequence ID" value="XM_018301220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865327"/>
    <dbReference type="KEGG" id="chig:CH63R_06245"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06245"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF40">
        <property type="entry name" value="NORSOLORINIC ACID SYNTHASE STCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="399"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1324"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1692"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1487"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1776"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1780"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2123" mass="230317" checksum="0F4839E4F882425C" modified="2016-11-02" version="1">MSSQDQVFAYVFGDQTHDIADTLSGLAQSHHDPLVINFLERSCGVLKHEVARLSPEQQERCPRFVTLADLLSPYRSETLNPCFVQGLTCITQLGLFIRQHSSGCQVYPTPENSLLAGACTGALAAAAVSCAHSAPGLLQPALHAVAVAIRLGALAWDVADRVAIKHEGPGSSNSFDSWSRVATGSSRKILADALLQYAADTGLPVITTPYISAIIGTTQATISGPPMVLSDFFASTIGKSVAPVSASLRITAPYHSAHFYNELDIEKVLAGINQNDLFKARIPVISASIKGQLLSTNATLRDALEQAARDCLEREMALEQLPIRIAEHIKRSVKSVAGNVTDVIIQPFAFHSTDRLVSPVRRLLPSESYWVQERSPLVPEELASRAANDALGANGGASKSPIAILAVSGRFPGNADTMDAFWDILHNGVDTHEMVPASRWNASAHVGDPSVKNVSGTGFGCWLHQAPLFDAAFFNMSPREAAQVDPAQRLALLTAAEALEKAGIVPNRTASTQKHRVGVWFGATSNDWMETNSAQDIDTYFIPGGNRAFIPGRINYHFKFSGPSYTIDTACSSSLAALHLACSALWRGEVDTAIVGGTNVLTNPDMTAGLDRGHFLSRTGNCKTFDDEADGYCRGEAVVTIILKRLEDAQMDKDPVEACILGVATNHNAEAESITRPHAAAQKDLFEYILTEANVSSNDISYVEMHGTGTQAGDAGETTSVVTTLSPLTARGTSVRPATSPLHIGAVKSNVGHGEAAAGVTSLAKVLMMMKHSTIPPHIGIKTKINHRLPDLQARNTHIATVPTPWVRPQNDSRRVLLNNFSAAGGNTAIVLEDAPPVLDNHTDPDPRRHHIVTLSAKTGESLVSNLRILIQWLDEAASWKDPNLLAKLSYTTTARRMHHRYRVAVTATSIPQLKSSLQQELDTCSGGGKILPAPAKAPCFVFTFTGQGSPHAGMGADLYSRFASFRSSLQRCDHLCVQMGLPSILLLFEERDYFSRASLTALQLSHAAFQMALCKLWESFGTVPKAVVGHSLGEYAALYAAGALSQADVLYLVGKRSQLMEEHLVQGTHAMLVVMAEAAAVLAAIPGVVGRDLEVSCLNRKQSIVLGGTVAHVKEAQKILEAKGMRCDVLDTAHAFHTSQVDPILAQFRKVAKSIHIRQPAIPVISPTHGRVLREAKDFGEGYLAEHCRNPVNIMHAVSVAKAEGVLDERTIAIEIGPAPVVAPMVKEVVGSRMQTFASAHKTIDTWQLITEAFSGMYTAGANVEWSRYHADFPECQQVLQVPSYGWTLKEYWMQYTNDWSLRKGDAAAAFMGPANLAFSSIYNVVKNTLQPSSDGEVVVDLDLNADDVHSMAQGHKVYGVPLCTPSVYADISQMIGKYVKQITAMDVDTIATEVADMHIQSALVANDVGLKQVFRTEARFDAATKSLFCTFSSFDDNDKALEQHASCSIRFVQIDVTKSRVEQAVSQARIRMEAIRAQVGRDDSTFRFSKSMIYKMVGQLADFEPGYRGLSAVTLSNNTYEAVGTVSFKGIPDFGKWFSNPAFLDSISQLAGFVMNANECVDLDKELFVNHGWESMKLLTPRLDPNTTYHSYVKMTEGKDKLWSGDVIVFDQDQNLVGILGGVALQGVPKRLMNYIINSAMKKVSRDSPSAISQIRPQPQAIPASEMDATFGDIYSAETQAAPTSQQATDDSWPVVLKVLAEETRLDPKELADDVVLADIGIDSLLSLVICCRLREELEVDLPERALFEECRTVGDIKTRVSRPVLSLSGFSRRGSDLMSTKSDTDSSIGSPDLDNPVSPFSTVMTPINSLDTPGTSPTLGSYLKVIDKGIGEFKGNVVPSTPSATATIPPAWSMYLQGSRTKARETLFLFPDGCGVATSYSSLPTISPTTALVGFNSPFAKTPSRMYDHTLREVLQSYVAGLRQKQAHGPYRLGGWSAGGILAYAVAQELISAGEEVISLTLIDSPSPNHGLDHLPERFYDHCNKVGIFRKVLERGSDQSKPPEWLMPHFRATTELLHEYHAPPMSPEAARKLHVNINWAGECAFDGVTYPHLPPAMKEGEDCEGMKFLTEKRKDFGPGEWALLFPGASITTTVIEGQHHFSMMRGSGATRLVESIRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIN5</accession>
    <name>A0A1B7YIN5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_04138</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160359.1">
        <property type="nucleotide sequence ID" value="XM_018299113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIN5"/>
    <dbReference type="GeneID" id="28863220"/>
    <dbReference type="KEGG" id="chig:CH63R_04138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04138"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="537"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="619" mass="65850" checksum="6C51307F68AD43F1" modified="2016-11-02" version="1">MSGPQAGSQLNIDRYVVIHVATTCDEHGVYVTKDSAEVIELGWILLDAKSLEEITRESVLVKPINTPITPLCTSLTTLTWEHVRNAGTFRDAINRFDTFANEHLTSQNLDFVFVTLDAWDLRVQLPREARDKAVVLPPYLQHSRTFDLRTEYQRWQQHHPESLPFGPSMLSNICAALEVEPVQSSAPIKHNLPFHLQALAPASPRRAMEEAVTLARVLRGLIRKSQPSHEHPDVLTRPMDARADVRAFLSERSKVLHMSGLPHDTTQSELESWFTQFGGRPIAFWTLRTPEQHKPTGSGFAVFSSHEEAAESLCMNGRALNEKAIEVSPSSSRVLDRAAEILTPFPPSKNRPRPGDWTCPSCGFSNFQRRTACFRCSFPAVSAGPTGDMGYGYGYGPPAIMPPSQHHHGHMGHGGGRMGGSGVVPFRAGDWKCGNEVCGYHNFAKNVCCLRCGASRAGAAVVADSGGYPSPMDPPSNYSMSQGSMSGTPGPGPFASAGGGFASGGGGYGGQHFGGPPSTYALPSGIGGGGAAPYPSSLNTHFGPAPGSHSAGPFDSRAAEAAFQSASNGPASAGPSNNFYSQNENDPFAFLSSGIGGLSVSGGDARQNGGAAPPSKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ27</accession>
    <name>A0A1B7YJ27_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160594.1">
        <property type="nucleotide sequence ID" value="XM_018299348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ27"/>
    <dbReference type="GeneID" id="28863455"/>
    <dbReference type="KEGG" id="chig:CH63R_04373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04373"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="761" mass="83310" checksum="FBBC9DC95EE53F29" modified="2016-11-02" version="1">MFYHGGMASPPPSDDLVPASSPALPSSPPPCISRKEKKKAVLTPRKFRRFFTPRGMPSHISRERPALGELGSPAINAQPTPPRSSFAEPISPSSNNSSLLSPFGSGDGPKKRKRTVVNPIPMKLPPLSRCSNSKRLRTQLEDLAEDGDMPLGRSPLARSSFGRDENTPPEDHVMTSPEAHSPSNRRTTALGSKYSAGPQTTPEEFARKLSSLTANNFANVGYDGLRPRSTLIDYFKCNRAGVPSASRLKPVTALAKRTQLVKDEATLPEYRPQPVIKLRNRGFGAQLLLREQGSTSRPGRERLEYPAFDAPMTAIGDEEGFIRFFDTATTPLGATPRTKVSIVIQAHENAIMDLAFSDDDLRLASACGDRSGKIFDVMSQSVAVELNGGHFQSMRRVEFQPGQANGNVVATSDRDGKIQIWDLRCCNTPANAFSTRGPEGIVHRNRHQPALWARTTNTLDNAHARTVEGVTSPASVTALQYMPPGREHLLLSASEANACIKLWDTRYITPRNKDASPLAVTAEPPTHRWRPYGLTSLALSSDAARLYAVCKDNTVYAYSTSHMMLGHAPELSLHPPRQKAGSAVRGLAPMYGFKHDLFHVKSFYVRCALRPVSTSGTELLAVGSTDKCAVVFPTDERVMREHWDTQSHLPISDTINLDATTPQSKQPLAGGQVPIVRNGTPLIRGHRREVTGLSWSNEGKLVTISDDYMARHWQEGDDDSSGGRDAWNLRTGGEFGGNRHMAGWADVGDDWDEDCDSHSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJD5</accession>
    <name>A0A1B7YJD5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160673.1">
        <property type="nucleotide sequence ID" value="XM_018299427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJD5"/>
    <dbReference type="GeneID" id="28863534"/>
    <dbReference type="KEGG" id="chig:CH63R_04452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04452"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="347"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="53094" checksum="DF180BCCA0B3A4F3" modified="2016-11-02" version="1">MSEEAGSGASDPLHVIIIGAGLAGLATALSTKLANPSHRVTILEAVKELQEVGVSCSVALPFNHLPPPSSLLRSQSLSQAGLQLTPNATRLLDAWGLHSSLSVLATRPSTLSVHRYDGARLLAHEPRLQETIQSRYGHPFWGLHRVELQRALVDRCTALGVELRLSSRVRSVDFARATVTLDHEDRDVATAIASASRPGSTIAGDVVVCADGMWSATRAQFLNRPSPLALTGDLAFRIAIPIDSLKGPHKAELEAFIESETVHFWIGPRSHGVSYTVKQGRMLNLGLLSPDNLPEGETKVIGDVEEMRSLFSDWDPLLRKLLDQVESVHKWKLCWVEPLDQWASPDGFFFMAGDCCHPMLPYLAQGANSSLEDGAVLGYLLGKVGGRGTKDAQLPAAAAMYQRLRMGRGQRIVMESFRQRDDFHLPDGPEQERRDEVMMASLRPGEEPQPGFPSRWTCPEIQGFLYSYDAYAEAETAYRRDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJG1</accession>
    <name>A0A1B7YJG1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_04456</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160677.1">
        <property type="nucleotide sequence ID" value="XM_018299431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJG1"/>
    <dbReference type="GeneID" id="28863538"/>
    <dbReference type="KEGG" id="chig:CH63R_04456"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04456"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000303">
        <property type="entry name" value="Protection of telomeres protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="11">
        <location>
            <begin position="189"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="672" mass="76335" checksum="A496467CB83CCF92" modified="2016-11-02" version="1">MAGSDVGTAMDLPQGYAKIVDILGEKVTAGGFLNVIGIVVDFQKPIPTKGGDYKARIRLFDMSVSGENRDMAFDIFRPSSQMFEVGAGDIVVIHQAKCQRYRSDPLSLITSYTTAIHIYPAAKIPPSPAQPASNPLMPSKQDSSRKPSLKDEQYISWFFHNVDKTYIPDIEQFNIQATRSLNVKDKLCELKDVKDSTFHDIIAQVVQEPYDYNDKIRLYVSDYTENSGFFNYRRDGQVDNNSRDGDPYGYTSGKAGTPKWIGPFGKRTLQITCWEPHATVIRQRVKNGSWVHLLNIQFKFGTNGRNLEGYLRQDQNAFPNKVYVDVLDLSQDSEQIHPSLKNAIRRKRDYEKEEKAQRTELQPAQKTSKKRPAAEQPEDKRLNAKQRRAIQRAQAAEKATHGETSTKTSSDLNQQVIAEYPEQPAVPVSVILEPAKYETAHQGGPLLLDLPFTCAKYRTNVRIIDFYPRRLQDFARVRKQTECDILSDYSGTDSEPEEEAVTIDSFVDAGDRIWQWRFALRLQDVTAAAKDSSGQKDNSFWAVVDNMDAQLLTSLDACDFRVNPDELTRLREKMFILWGDLEEKKAKELENTSKKQKAKMAKKTASDRPPDSSDNEEPTKKEKEVILNRPFTCCIRQYGVRVNESNPDKANAGEGKRWKRMFGLFGTKICDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJX5</accession>
    <name>A0A1B7YJX5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160894.1">
        <property type="nucleotide sequence ID" value="XM_018299648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJX5"/>
    <dbReference type="GeneID" id="28863755"/>
    <dbReference type="KEGG" id="chig:CH63R_04673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04673"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="372" mass="38911" checksum="FBA36956DBAE006E" modified="2016-11-02" version="1">MSAVVEKVSEAVNDVTNALSNATISDKAADKPAANNDAVLASAAEGRRLYIGNLAYATTEGELKEFFKGYLVESVSIPKNPRTDRPVGYAFVDLSTPSEAERAISELSGKEILERKVSVQLARKPEPAGEKAEGANGEGAGEGNRRRASGRGRGRGRGRGGRGARGGREDGAPVEGAATEVPAGAPATSEVLPLTDTTNKDAKSDADKQARAPRERRERGPPADGIASKTKVMVANLPYDLTEEKLKELFAAYEPSSAKIALRPIPRFMIKKLQARGEPRKGRGFGFVTLASEELQQKAVSEMNGKEIEGREIAVKVAIDSPDKTDEEANAPKEETKEEVKANGTGAPEAAAAPAAAPAASTTAAPAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKD0</accession>
    <name>A0A1B7YKD0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161050.1">
        <property type="nucleotide sequence ID" value="XM_018299804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKD0"/>
    <dbReference type="GeneID" id="28863911"/>
    <dbReference type="KEGG" id="chig:CH63R_04829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04829"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447777" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="599" mass="63535" checksum="DC45C975E52DB940" modified="2016-11-02" version="1">MLQQLAVLVSALGLCHATTQIVTGASLFVGDSSPIVNTSYARFQGKNDNRTGTSNYLGIPYATAARFSHSVLADTAVSGVQNVSAYGVVCPQHELPSSIDPSVLPLGSLSGVLVAALSQSTLEQGEDCLSVNIHVPQNTSSTAGLPVLVWIHGGGFEAGAGGSLLETGVESPGVVYEAANIVERSVAMGQPVVVVSINYRLNHFGFSASKELADAGLLNLGFGDQRNALRWIKKHIGPFGGDADKVTIWGESAGSWSVAAHLVANGGDHEGLFRAAIGSSGGPLKVEGPARQQATFDSLVSYVGCNDAADVIACLRDAAYDDVYTHMQTVPYFLGYNSLASSWTIRPDGDVFTDSPDKLVASGAIADVPLLWGDMRDEGTLFSLVNAANTTTDDEVLDYFLTNWWPNATEAQLEKLLTLYPADQTAGSPFGTGDSNALYPQFKRISAITGDYSFESQRRQLLAAAPGSKWNYLAEQALPAAVLDGTATLGEVTAADYADVGTLEAVPFLGSFHASDVVLNFFGALPSNNSRRMMGALIAFVNRLDPNAHDMEDVPAWPQYDSASRSTMLWRESGAEIVADDYREEAIAYLNEIGDSLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKW1</accession>
    <name>A0A1B7YKW1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-l-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161035.1">
        <property type="nucleotide sequence ID" value="XM_018299789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKW1"/>
    <dbReference type="GeneID" id="28863896"/>
    <dbReference type="KEGG" id="chig:CH63R_04814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04814"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="499" mass="54880" checksum="EEBE348FA5FE9E3B" modified="2016-11-02" version="1">MDSSEFRAAAQEVVEDITKYYDTIASQPKVLTSVTPGYLRPLLPAAAPEDPESWQAIHADLQSHIVPGITHWQSPSFHAFFPCSSSYPAMLAELYSNAFNGAHFNWICSPAVTELETIVLDWLARLLALPACYLSTAPTRGGGVLHGTASEAILTVMVAARDKFLRAATAHLPDGSDEKEDESWRLRSKLVALGSEMAHSSTKKAAQILGVRFATVPAPAETGYAMSGAALAETVAALRARGLEPFYLTATLGTTDTCAIDDFPGIRDVLSAADERDRIWVHVDAAYAGSALMLPENAHHTEPFATFHSFNVNPHKWMLTNFDCSALWVRDRAWLVESLSIKPAYLRNQFSEAGLVTDYRDWQIPLGRRFRSLKLWFVLRAYGASGIRAHLRRGIDLGERFADMVRSRDDLFEIITGPRFALVVFTCKGADRAEGNSVTEAVLEAINGEGVIYLTPTTLHGTYGIRMCTSSSQIGEEEHIKKAFDILVATTEKTLAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLE3</accession>
    <name>A0A1B7YLE3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161384.1">
        <property type="nucleotide sequence ID" value="XM_018300138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLE3"/>
    <dbReference type="GeneID" id="28864245"/>
    <dbReference type="KEGG" id="chig:CH63R_05163"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05163"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="6701" checksum="FC020404F8ADBC4E" modified="2016-11-02" version="1">MASQRSGAPFSSVGTVAARYGPPGHLMAADDATLISPCPPEVASTFPAPAVSSRRPLAQRDYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMY3</accession>
    <name>A0A1B7YMY3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161924.1">
        <property type="nucleotide sequence ID" value="XM_018297108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMY3"/>
    <dbReference type="GeneID" id="28861215"/>
    <dbReference type="KEGG" id="chig:CH63R_02133"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02133"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="42494" checksum="C1EBBA0B7AD7E91C" modified="2016-11-02" version="1">MRIPPIDVLMNWPRPNYINPVDRGPGLLIIETAFLGLALTCLCLRMYVRMFMIRQTWWDDWLMCAGMVFCIGVTICVILATEMYGWNLHVWDIPLSLIRQSRQVGKHSEDLFALEAFYETDDPPEQISMAAQTLFLFASGLSKLSILASYLRLAAPGTWFQRLTWATGCLVFTLTWVFLIVLWTQCMPIWHYWTLFADWGNCIPEWPPLAGQGITNVLTDVAVYLLPMPTLFRLRMPLGQRISLVVLFGLGTVVVVAGVMRTYWVLQVEIRYAVDPAYDLTWDGFNIWVWTALEVNLAIVCGCAPALRRLFTGGKQENTRPAQGSVPTIGCWGQKWKKGAQETQQGNDEEEYRLAMVQTRSMCTKESSITKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNG8</accession>
    <name>A0A1B7YNG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161989.1">
        <property type="nucleotide sequence ID" value="XM_018297173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNG8"/>
    <dbReference type="GeneID" id="28861280"/>
    <dbReference type="KEGG" id="chig:CH63R_02198"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02198"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="92" mass="10033" checksum="3742459B22CE260E" modified="2016-11-02" version="1">MSSASTFSQTTEADFDLYAYCDPPPCHLIPSSHIRNGLRHPFTEGLGCQHWRDASLEARRGICSTPKTPNDAEPLVACGWLAGQLKTTQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNS7</accession>
    <name>A0A1B7YNS7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162228.1">
        <property type="nucleotide sequence ID" value="XM_018297412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNS7"/>
    <dbReference type="GeneID" id="28861519"/>
    <dbReference type="KEGG" id="chig:CH63R_02437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02437"/>
    <dbReference type="OrthoDB" id="10394942at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="156" mass="15445" checksum="DAB8E77F672C42A8" modified="2016-11-02" version="1">MPVLGGIEVGVSDDTSEVGQGVPSFSEGTLLATGSLKTHVGGCPAPVDVGCETADDGRVWIVRVRVAVDETVMAGEWDVVDGGGVDDEGGGVAGGEDEDEDEDEEGEGLSALAGPEVGGEGVVAATMSSLDAEGTAGDGVPRAEDFVVAVAVRGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPK5</accession>
    <name>A0A1B7YPK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial oxaloacetate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_02544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162335.1">
        <property type="nucleotide sequence ID" value="XM_018297519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPK5"/>
    <dbReference type="GeneID" id="28861626"/>
    <dbReference type="KEGG" id="chig:CH63R_02544"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02544"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601820" evidence="12">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="310" mass="33888" checksum="6AD16E5EDEB6E7D1" modified="2016-11-02" version="1">MSTTLGAFIAGGIAACGAVTATHPFETVKIRMQLQGELKDKGHQPHQYRGPLQGVSVIVRNEGVKGIYRGIGCAYIYQVLLNGCRLGFYEPMRETLTTLVFNDSKTQSLGVNMACGAGSGIMGAAAGSPFFLVKTRLQSYSPFMPTGTQHNYRNAWNGMTTIYGSEGIRGLYRGVGAAMIRTGFGSSVQLPTYFFAKRRLVRHLGMEEGLPLHLASSTVSGFVVCCVMHPPDTIMSRLYNQNGNLYKGVFDCLAKTVRTEGFLAIYKGFLPHLARILPHTILTLTLAEQTNKLMRRLEDRILPTAALQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPL4</accession>
    <name>A0A1B7YPL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin interaction domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_02618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162409.1">
        <property type="nucleotide sequence ID" value="XM_018297593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPL4"/>
    <dbReference type="GeneID" id="28861700"/>
    <dbReference type="KEGG" id="chig:CH63R_02618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02618"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="5">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="628" mass="69135" checksum="24E1CECB6820D405" modified="2016-11-02" version="1">MSSNSRAQSSSPGAEEDPDLALAIALSLQEQEDIGIECVKTATVPERHVEKTTKPAPVTNFGALILDRKKMEEERLARLKKRSATQAELDDDQSRRPKIQRPEAPSKRSTSDASPGLPRKAPTAGDSPSLPFPNGVFKRTWALGYPRNGEDIKIEEVLQKDKLQLAVLSSFQWDEEWLLGKVDARQTKMLLIAYANNEAEKATIRANAPTGLVRFCFPPMHGGYMHSKLQILKYEGYLRIVIPSGNLVPYDWGETGVLENMVFLIDLPRIGGTHQTAPPAGTAFGTELRRFLRALGLDEKLVKSLDNYDFSKTSRYGFVHSILGLATEEPVNIDYVGTLLINLSSKASSLGSLTHDYLTAIYHACQGDSGMKEYEARQSKPTRNKAAKAGLAGSRPLGEGTLQWQHHFRIYFPTEKTVSSSRGGRSSAGTICFQEKWWKSSTFPRELLRDCQSVRSGLLLHSKSIFVRGRAGGDAAWAYVGSANLSESAWGRLVKDRESGAAKLTCRNWECGVLVAVEGNPTGTADSGTRPGVDQDAHSRRHPWARVQAQTLEGYARDEETSTSRGVAAATAADSEENRRQQQLDRDESAGLDEVFGTTVPIPMKVPAGRYMSDESAASRPWFFMKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQQ4</accession>
    <name>A0A1B7YQQ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162799.1">
        <property type="nucleotide sequence ID" value="XM_018297983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQQ4"/>
    <dbReference type="GeneID" id="28862090"/>
    <dbReference type="KEGG" id="chig:CH63R_03008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03008"/>
    <dbReference type="OrthoDB" id="4773508at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="350" mass="40157" checksum="52945DE212F46BE5" modified="2016-11-02" version="1">MDEHEVTDEFAEWTEQDGCFQDHSLSISLSATNSSNATGIECMMTLIRSINRMLPHEERDPRIPERNLEESRNPLLLRAWTLKEWTLADKTELVSWMGFSEVESAAFEEILTLPLMNKTLWARKQHHLSDRYIVKSDSSEWELAQDDCDYERARRSLIRIEHKSGSDPVDLTAEIQRKFDYIDIFADGSGQSFLARPPVFARILYTPSEDDVDDNLEALQVISIKDQGQEDETLDADLDRLLWRYVLVAAVRLRDRPNGHDKIRLFTPDGADIARSVNGLYNDPYWHVGARGHSYFLLGLEKSFAVIMKSLPNALSKLDSDSGQILQSLLAPPRLWEVKPLRVVVWLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQS4</accession>
    <name>A0A1B7YQS4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162904.1">
        <property type="nucleotide sequence ID" value="XM_018298088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQS4"/>
    <dbReference type="GeneID" id="28862195"/>
    <dbReference type="KEGG" id="chig:CH63R_03113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03113"/>
    <dbReference type="OrthoDB" id="5209965at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="39443" checksum="61F31DAD3CC306D3" modified="2016-11-02" version="1">METKSTPQMKTSSDHGPAAMSSLGSDTGDPPASAVSPRNANDNSKMLPTQFEQYGSLTSEPAIQWPKLKKVAPKTMLEVNKEPLPWMQKQLRRVQKEENISQQVRDQKSADVELWRSQLRKISALDVGSLDHDEDVDHGNHKQAGTCLTCPRETPSSSPLLDDLVTHTPDIPKRLSGAECVGQDDQDDQIHNLEQKRLKEIRASSSQRSSSRISTMTKVESTTVTHVYQVNEPVYSTSESLTAKENIAGSAEQACKELSRSHTSAIEVFSPMPIMPPNHTCSWKDRYLNLTAEVRQLKAEILSQERRKSSELVDVGVDVGQGEDYGLGVEGLTIVMHLKGKDDLIINTDLTQASSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS51</accession>
    <name>A0A1B7YS51_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_00047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163384.1">
        <property type="nucleotide sequence ID" value="XM_018295022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS51"/>
    <dbReference type="GeneID" id="28859129"/>
    <dbReference type="KEGG" id="chig:CH63R_00047"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00047"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="367" mass="41196" checksum="EB2D9937E3360A59" modified="2016-11-02" version="1">MGDVIKEVPLTAVRVEALVVMKIVKHGSQTFPTTATGSIVGMDSDGLLEISNTFQFPTVDVANTDSHSHSNNSNDASALAAAAPRQKANIVYQNEMIKHLKEVNVDANNVGWYTSAAMGNFVNLSFIENQYHYQKDNERTVALVHDVSRSSQGSLSLRAFKLTPAFMAAYKEGKFTTESLKASKLTFKDILAELPVEIHNTHLLTSFLHQLPGLPQQDSIERPNSLSDLREDPIKQQLHPSVENLDLSIDPFLEKTCDLLLESIESHYTDLNNFQFYQRQVGREQAKITQWQAKRKAENAARAAAKQEPLPEDEWQRLFKLPQEPSRLEGMLNAKQVEQYSKQVDGFTSNISAKMFAVRENLLPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSE1</accession>
    <name>A0A1B7YSE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163474.1">
        <property type="nucleotide sequence ID" value="XM_018295112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSE1"/>
    <dbReference type="GeneID" id="28859219"/>
    <dbReference type="KEGG" id="chig:CH63R_00137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00137"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="83" mass="7938" checksum="06C59A82049C00A8" modified="2016-11-02" version="1">MCFGGSRRRTYGGGGGMMGGPRPAVVQTHHHHHGGGMGGGGMMGGGGRGCGPRSGFGGGGGFGRRGMGGMGGGGMMGGGRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSQ3</accession>
    <name>A0A1B7YSQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163574.1">
        <property type="nucleotide sequence ID" value="XM_018295212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSQ3"/>
    <dbReference type="GeneID" id="28859319"/>
    <dbReference type="KEGG" id="chig:CH63R_00237"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00237"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="188" mass="20805" checksum="9AFE702BD2A64082" modified="2016-11-02" version="1">MILLHRPFLQSTRPFQGFTLSETGRFDVHTVSCRKAAQWIATILQIYHKNFTLRKLPISAVHCAFTAAVIFLADATSEDDELQQESLKNLKTCYRSLQGMRTAWGWSERAISALEQIAIRWKVEIPGVEAAAPPTGMDCEDETTSTSTHLRKGGPSGGEVPIPADDSSAQQPVDNWLDLDTLLSCSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTG2</accession>
    <name>A0A1B7YTG2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_00422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163759.1">
        <property type="nucleotide sequence ID" value="XM_018295397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTG2"/>
    <dbReference type="GeneID" id="28859504"/>
    <dbReference type="KEGG" id="chig:CH63R_00422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00422"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="800"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="883" mass="96616" checksum="414FDCCBDC030211" modified="2016-11-02" version="1">MSLQVRGPDFSVTKQKALEDAKKMQAAVDDEVTKAGQDKPPYLLNELIGKGSFGRVYKATDINTSMLVAVKIIDIEESDTVNPKLADTFKEFLAEVNALKLLSDSGAKNINHVIDALPVGQSMWMITEYCAGGSVATLMKPTAPGGLQEKWIIPILREVAEAVSWVHRQGIIHRDIKCANVLVTEAGGVQLCDFGVAGVIETKFDKRSTFIGTPHWMAPELFDQSTSYGTEVDIWAFGSMVFEIASGLPPNVMAGIDVYQLGNYIKAHTPRLEGDQYSDRLKNLVAYCLEEDPAKRPTIEQVQKHPYIANTAQEYPASSLALLVKGFKLWESQGGSRKSLFAPGGAQGMSGMDDSDFSSTAMANDEWNFSTTMAFDQQVFQNTDAQAVYDVYGSNVDFDPGLLGEMSRAKPKARRRPPPQQLAAMKVPLEKVFDPNTISNYEDNSRAYYGRPIPPPTSDLPLRDDSLQSTAVRESLIDLDASLSGGDLANFVDMDTIRAGGPRVSVDYHMGDEPDFNKPPLSDPADMNPNRKTQDWKFPSMAPPASANPEMSRFPFNEDRPFHEDRSFSEDRPFVFPALEEDRSAPNPASRPQMFHHQTEPVPAPSYGNDLMAPRPNSQMNNRESTGSLIDLDELMVPETNYQNNRVSTGSLIDLDMGLADPMPELTRPSTANSDAASVSGSDIGMANPFDLERHASLYVPTTNREPSIYVPASNREPSIYVTASNREPSIYVSDDSDFASKIPRDEDLSLADFSMAEPGATVRPSNGQSGLRLNTHRSFNSVNSADYSDPEYLTPQQAALPTLPLGGPRSTGSRDSGILPLPPPPAPPSVEVMQGSASADAVKEELRRMAMSLGEHLSHANQYLSTLPVRKGGRQDLMGETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVH6</accession>
    <name>A0A1B7YVH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DSBA-like thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164540.1">
        <property type="nucleotide sequence ID" value="XM_018296178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVH6"/>
    <dbReference type="GeneID" id="28860285"/>
    <dbReference type="KEGG" id="chig:CH63R_01203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01203"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="239" mass="26277" checksum="5C85B77C7A4A15BC" modified="2016-11-02" version="1">MNASRQASKMTNINIKIISDPVCPFCYLGNARLNRAIDLYKKTYPGGKDDTFNVTWQAYYLNPTAPAKGLPVNEVMASRFGADRLEMMHAHMKKLGVAEGFNFTFGGKTGHTRDAHRAIQLAKSKGPEVENAVMTSIMKSYFEEDGDVTSWDMIVDAAARGGLERDEVRKWLEEGKGGREVDEQVEDAYRMGVRGVPHFVINDKYEVGGAQEVGEFLRQIVAAKEKGGQGSSGGEGLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW37</accession>
    <name>A0A1B7YW37_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2OG-Fe(II)oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164774.1">
        <property type="nucleotide sequence ID" value="XM_018296412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW37"/>
    <dbReference type="GeneID" id="28860519"/>
    <dbReference type="KEGG" id="chig:CH63R_01437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01437"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="60"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="277" mass="31390" checksum="60335A6962222C01" modified="2016-11-02" version="1">MNTERAKKDNDRGRTLGYRNLSLIWIALVAIPLSVYLASGLSLFDVRETRLTTTIVSFDPLIIYLEDFLSASEVKYLKQIAQEKYVPSKVVDENNKKLDKTSFTRRSSSAFLPRQDDVVKSVIARAARFQGFAPTNHFENIQATKYVSGQEYMPHYDVFSAKPSLYGKEDGSENATERLSTMFVILEDSCGTHCGTQFPQIAIDWASEDPRWCEFVDCAEKRLTFPPRAGNAIFWKNLREDGSLHEDTLHAGLPLQHGAKIGLNIWMRNGIYPHVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YXB7</accession>
    <name>A0A1B7YXB7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165111.1">
        <property type="nucleotide sequence ID" value="XM_018296749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YXB7"/>
    <dbReference type="GeneID" id="28860856"/>
    <dbReference type="KEGG" id="chig:CH63R_01774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01774"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="668" mass="74985" checksum="E1E09C286A4E3C90" modified="2016-11-02" version="1">MLHYFTPSTCSNTVLDAADTALSAQCAKQQAIPHPQTKCFPVTLAVNTIATQPVNSLSPPVHRDRPPSLPDEVRAGRYKPAISASQASPSLVSLSSPRFRHQSANKADTWFVRHPYYSKHNPSKDLTSHKVLFPFALNSTESHAGYWRQAQSISAPSTPVPQRVLQSIQGTAGHAVRAVSARIPDGCSPAAPTAHFSHNQGRPPIPVKRLYTLQRNAVWRPLIDRWCLFRLAESSFNILRWEWMAVSCVDDFWIPWIEETMMFIRAVQASCCPEFNPTQEAWEWLRQVTQGLPSRSSKEPDVAANIGTADASRHRQVLQYCVSEAAYLMPDINHCLNEKKHNVDVLSKVMHHISFWAVSSSNNSQETALLTPTYRQRLVLLLTAVIIQLRNNPSQGPPTLSAFCNKLGLLLEGSPTAGDVIRGCKTPSCSYPHAIPLQYYQTLLQQPAHQPNNRLAEVLSIEFQNDVWRTVSSSMSQWRTPEMQKTLLSIARVRSPEYMARFQPDSPWAQVCNVVRRWFSNQSQLVSFALRKVDEEDKEIAGPALLPLTPLWKSIVLRRIMRIRPEYWPPYNQVPPFVIAGFTALENRSLKNDKFDKTAAHFHLARSVLDDLIAARPKVAEILLLTALVFGHATCTPFVRPGLATFEPTIKAPRSGCERTAALLTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVB8</accession>
    <name>H1UVB8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00721</name>
        <name evidence="12" type="ORF">CH63R_02944</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000269">
        <property type="protein sequence ID" value="CCF31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162735.1">
        <property type="nucleotide sequence ID" value="XM_018297919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVB8"/>
    <dbReference type="STRING" id="759273.H1UVB8"/>
    <dbReference type="GeneID" id="28862026"/>
    <dbReference type="KEGG" id="chig:CH63R_02944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02944"/>
    <dbReference type="eggNOG" id="KOG2609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051065_0_1_1"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="34774" checksum="C8EB771009A4ACAD" modified="2012-03-21" version="1">MPPSKKRKTNKGSAAKTENTVAASSAAPAEAETTGPLTTTTDAAAPAPTEPAEVPSTSQPTEEDAAAKAKDRMARFKALKARAKSSSDQNFKEATLESQRLASDPSQLTAIHRKQAIASQKLLKADVEDAGGDFERKRAWDWTVDESEKWDKHVRKKEAHRDNNAFQDYTAESNKVYKRQLRNIAPDMEKYEKDKMAAIERAAASGGLDIVETEDGELIAVDKDGSFYSTADSTTFAQNKPDKAAVDRLVEDLRRAEENRLKKRKDRMAQNGDDGDVTYINEKNKQFNQKLARFYNKYTAEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX87</accession>
    <name>H1UX87_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ RNA-binding domain-containing</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00830</name>
        <name evidence="7" type="ORF">CH63R_00601</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SZRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000469">
        <property type="protein sequence ID" value="CCF32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163938.1">
        <property type="nucleotide sequence ID" value="XM_018295576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX87"/>
    <dbReference type="STRING" id="759273.H1UX87"/>
    <dbReference type="GeneID" id="28859683"/>
    <dbReference type="KEGG" id="chig:CH63R_00601"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00601"/>
    <dbReference type="eggNOG" id="ENOG502SDN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060774_0_0_1"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="70"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="5">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="290" mass="31224" checksum="6998CC40144EC2CA" modified="2012-03-21" version="1">MVKNAPVPDAWEDDDWESAADKLDGGAPLQPEPEPQAPMSKAERLAQHAESNRKLWESADSPTPLTFLEAQPSVPLATGFKPQVKVLSRKPAPRTIARRDPVTGLLSHLSLADDDADDQRADAKPQLTPEEIRAKQQRELEEKQRRYEEARAKIFGESNPSSGASSPGTTTPPRGGENERGGGGRGRGRGRGRGGGHRGNHSSRQEDYRRPGSSRSDAVRSESGRELYDPGYAPRGGGFGLQKRGGDSGPHSGRSTPRDEDPPKQAMRAPRGPDGSGRGFGFAKRGTNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UY16</accession>
    <name>H1UY16_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_05203</name>
        <name evidence="9" type="ORF">CH63R_10437</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000570">
        <property type="protein sequence ID" value="CCF32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="968" mass="106567" checksum="7557AA32778D2695" modified="2012-03-21" version="1">MPSASSPITFPASSSPPAAKRTRPAAAEPTKPKPKVNSGFLLDDDSDDDDDNAQQPPLKKQLVDFTARLQRPAPLTTIPDEDILEPIAPAPQKTNDRVTPEPAQTLPTERPSSLASTLLSSTPSFLQSSRTFNLTTCAGTSTTIKQRKPTTNTSYESIIAARSKTKEGRAKRAYYGIDINELIDAAKQEASESRRPQRTESDVPVRSVEPSITGKSQKKTLLWTEKYRAKNFLDLCGDDGTNRMVLRWLKRWDPIVFPGVAKKAPIVRRPGAKQVQEEEKPHKKILMLTGPPGLGKTTLAHVCARQAGYDVMEINASDDRSRDVVKSRIRTSLGTESVKTVENVKAKDGETLQKVAKPACVIVDEVDGVVGGSGSSGEGGFVRALIDLVLLDQKNSAGASNAANRKKKKGDDFRLMRPLILICNDVYHPSLRPLRQSGMAEVIHVGKPGIDAVVTRLKAVLDKEGIPCEKDAARKICEAAWGITSGIDAKRGAESGTEGDLRGVMVVGEWVAGRFRAAAGFNDRLTRQWLEQNVLHDLTNGAGGGRGLGRGSAKDIVTRIFQEGGGFPKQALDTSQNFTHKHEQPKSQLGFAEYHKKNAMERLRHMIDTSGEVDRIMTDIFLEYPNREFNDDSFLSKPNAAYDWMNFLDTCSSRTFGSQEWELAPYLSQPILACHSLFASSRRHQVTMGYDKKWGGGEEDDEPPVPFSGPRADFAAHEALKQNKAMLQAIQAQLTPTLGRSFRSAEDISTEFMPYLVRMVSPDVKPVVIGGSGISTASVRKETEKAMVKRAAEVMAEVGIVMQKGKIETDSLVNRGPQWVYRMEPDLDALAVYETAGSLVLSSQAPTRYAVRQVLDQELQKTITLREAAARQARFTAGGPMGLEEIPVHDNKENILKEQARILEASVKRDFFGRIIPARPLGEVDGNAKRRKGHEHEKSDNKVWVTYHEGMNNAVRKPITLQEFMKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYD6</accession>
    <name>H1UYD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05263</name>
        <name evidence="4" type="ORF">CH63R_01215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000601">
        <property type="protein sequence ID" value="CCF32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164552.1">
        <property type="nucleotide sequence ID" value="XM_018296190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYD6"/>
    <dbReference type="STRING" id="759273.H1UYD6"/>
    <dbReference type="GeneID" id="28860297"/>
    <dbReference type="KEGG" id="chig:CH63R_01215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01215"/>
    <dbReference type="eggNOG" id="ENOG502S2CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_3_1_1"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="248" mass="26894" checksum="543F9398B7EC924B" modified="2012-03-21" version="1">MSQDRSKTVVAFDLYGTLLSTESIAKELATLYGDENATGLAAQWRRYQLEYTWRINSMGTYRPFSELTRAALKHAVAEKKLAMSEEDEGRLMDAYNGLEAFPEIEAAMDVVERDGSVDAYVFSNGTDDMVRASIGTSPGLARMSRALGPGKLVTVEEARCFKPDPRTYAHFAEKVGMSGREDGIWLVSSNPFDALGARAAGWRSAWIDRSGTGWIDGLGGVIGTAPTIVAVGVDEAVEQIVGLSKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0I7</accession>
    <name>H1V0I7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="10">HMG-CoA reductase</shortName>
            <ecNumber evidence="10">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_05871</name>
        <name evidence="14" type="ORF">CH63R_10650</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
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        <reaction evidence="10">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HMG-CoA reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR06530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018305624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0I7"/>
    <dbReference type="STRING" id="759273.H1V0I7"/>
    <dbReference type="GeneID" id="28869731"/>
    <dbReference type="KEGG" id="chig:CH63R_10650"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10650"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001734_0_0_1"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
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    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
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        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="417"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
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    <feature type="domain" description="SSD" evidence="12">
        <location>
            <begin position="244"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1122"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1124"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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            <dbReference type="RuleBase" id="RU361219"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
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    </evidence>
    <sequence length="1162" mass="125337" checksum="2CF32D9D7EC13787" modified="2012-03-21" version="1">MIPPSLLPSRFRGEQPDNRPSPPSRLNKKVASIIQCVSKIAYTHPIHTICITAILASTTYVQVVKETFSDATRTTSRTAEWTSLAEGSRHLIAGPETSWKWNNFDVATDLPNDAEHLALATLIFPDSSPNRLVSAPSPHTVPLPSNLSVSHLPLTFNNPTAYSHESALAFSIKYSEAPEFLAAVQEIPSLPADYESPAVKLGETEQKMWIMKLARAHTKSIVARWFHDAWTEFLYLLKSAETTDIIIMVLGYLSMHLTFISLFLSMRKLGSNVWLATSVLISSTFAFFSGLSVTTKYSVPISTVLLSEGLPFLVVTIGFEKKILFTRAVLSHAVQHRRPEETSTNPAQGVIQTAVQSAIRDRGYEIVRDYVIEIGILVAGAVSGVQGGLQQFCFLAAWVLVFDCLLLFTFYTAILCIKLEINRIKRHADIRKALEDDGVSRRVAENVASSNDWALNGKSGENGLLFGPEARRGSVPKFKFWMVAGFLAVNTVNLCTIPFRTAGVASWTGGIVATPPVDPFKIASNGLDEILFRARGLQQTTVVTVLPSIKYELEFPSAYYASSSTQHGDHIGDDNNHHQPLGYGYGVGAQMVGIISTSLENTVVLKWIIVALAMSVILNGYLFNVARWGIKDTDGQHDPNDLPKAAATESLTGTRGTDSRSGEAEEAIQPEFVSPASSDDEDEAEPRRVNVTPHSQAQLDKLLAEKRIYDMTDDEVISLSLQGKITGYGLERSLRDCSRAVRVRRSIISRTRATTEKTWFLEQSKLPYENYDWERVLGACCENVIGYMPIPVGVAGPLVIDGQSYFIPMATTEGVLVASVNRGCKAINAGGGAVTVLTSDGMTRGPCVGFDSLERAGAAKNWLDSEAGQSTMKAAFDSTSRFARLQLMKTAIAGTNLYIRFKTSTGDAMGMNMISKGVEYALNVMAAEGGFEDMKIVSLSANYCIDKKAAAINWIDGRGKGIVAEAIIPGEVVKSVLKSNVDSLVELNVSKNLIGSAMAASLGGYNAQAANIVAAVFIATGQDPAQVVESSNCITIMKNINGNLQISVSMPSIEVGTLGGGTILEPQSAMLDMFGVRGSHPTEPGENARRLGRIIGAAVLAGELSLCSALDAGHLVKAHMAHNRSAPATRSTTPAPRTNGATTPVGLTMASSTGERQKNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V327</accession>
    <name>H1V327_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_06583</name>
        <name evidence="4" type="ORF">CH63R_06002</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <sequence length="476" mass="54611" checksum="5FD00AF15E8068EE" modified="2012-03-21" version="1">MAFWVVGGEARPLSQGEGHAFNPDLYVVGGKRRIGHPDGNDFYDDYFYGHDDIPTHKKARISHLTSDTQHVYSPQASVPIQNLSFLVIREQTSPPPDPADAEVSSSQMERTASGLSISSDTNIYSAENDEDVRLLDDDAAARLVEDRLHLGRRRTKDTQHERILRSLIRPRSREAEFSIDNAALESIFSAANEIFFHNSLSQRVTWDWSHASSAQYKDHIIGTTALRRSKMGGFETLIVLSNPILKNRKYNRRLLISTFLHELIHSYLFIKCGVKARECGGHTVGFRRIAELIDLWAGSDNLHLRNMEADLDHFREDEHHLPVDDVSYMDTPFRAGFSEIQGYLSPNHHTHYDHQHYERRRYRSQDRWDCCINDHRGYFSVSRGSSPTSTNPTTAEEDFEEVDPLEEGEIREPRGRRLCPDDYMPSRQMSSHRERYYESHIRPSSYDGRWACPDDRRGAVALSYGNTPSSVVPSYV</sequence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <strain evidence="10">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">IMI 349063</strain>
        </source>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
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    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF36111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR08744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157262.1">
        <property type="nucleotide sequence ID" value="XM_018302484.1"/>
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    <dbReference type="STRING" id="759273.H1V7A9"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07509"/>
    <dbReference type="eggNOG" id="ENOG502S3SI">
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    <dbReference type="OrthoDB" id="3558022at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AIM11"/>
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    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
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    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
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            <begin position="1"/>
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        <location>
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    </feature>
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        <location>
            <begin position="13"/>
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    </feature>
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        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>H1V7K8</accession>
    <name>H1V7K8_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Cell cycle control protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="3" type="ORF">CH063_07829</name>
        <name evidence="4" type="ORF">CH63R_04951</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001883">
        <property type="protein sequence ID" value="CCF36210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161172.1">
        <property type="nucleotide sequence ID" value="XM_018299926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7K8"/>
    <dbReference type="STRING" id="759273.H1V7K8"/>
    <dbReference type="GeneID" id="28864033"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04951"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024195_0_0_1"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="140"/>
        </location>
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        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="336" mass="36793" checksum="CEFCDBECB1276B20" modified="2012-03-21" version="1">MPSDLSSYLATRYLVADPKPTKKRKRKQGAENQGLIIADDDDSGWGNSATHDDDADSGPALVSGTSAEFRRAKKSNWKTVVASSSTTTHPKDDDGAAAADAILASTAAENARAAAADDEMPVIEGSGGDDTGVVKMSDGTHAGLQSAAAVSAQLRRRQQAEEAEFAKLRKHGKEEETVYRDATGRRVDVSMKRAEARRLAAEAEEKERQAKLAPKGDVQVAEARKRREALDDAKLMTFARTADDEEMNRDLKDQERWNDPMAQFMSEKTGGAGAKGKRGKKRPIYTGAAPPNRYGIKPGYRWDGVDRSNGFEGERFKAINRRERNKGLDYAWQMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7P5</accession>
    <accession>I2G786</accession>
    <name>H1V7P5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EC14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07863</name>
        <name evidence="3" type="ORF">CH63R_03968</name>
    </gene>
    <organism evidence="2 4">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001897">
        <property type="protein sequence ID" value="CCF36247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160189.1">
        <property type="nucleotide sequence ID" value="XM_018298943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7P5"/>
    <dbReference type="GeneID" id="28863050"/>
    <dbReference type="KEGG" id="chig:CH63R_03968"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03968"/>
    <dbReference type="eggNOG" id="ENOG502T5XU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4788776at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497609" evidence="1">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="103" mass="11349" checksum="65C5035B5454D139" modified="2012-03-21" version="1">MHFTKLIIAVLLPLLAAADEHHGCRCNTGDEICLSRACNGYTEAGVFFKKPRGHEDTVFSQVKEGYCYAVYNNGQGFFTFHGLGGREWRAQCEEHCGGGSTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDD3</accession>
    <name>H1VDD3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_09378</name>
        <name evidence="9" type="ORF">CH63R_08818</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002878">
        <property type="protein sequence ID" value="CCF38236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155815.1">
        <property type="nucleotide sequence ID" value="XM_018303792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDD3"/>
    <dbReference type="STRING" id="759273.H1VDD3"/>
    <dbReference type="GeneID" id="28867899"/>
    <dbReference type="KEGG" id="chig:CH63R_08818"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08818"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011431_4_0_1"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
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        <property type="entry name" value="Rad52_fam"/>
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    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
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    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF38236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="508" mass="53674" checksum="A61080091EEEBB34" modified="2012-03-21" version="1">MPAPGDQHGIVANPFEEPQKRMSEYTAQEIATLQSRLEKQLGPEYISARAGPSGQKVHYIAAEKCIALANEVFGFNGWSSSIQNIQVDFVDEHPQTMKISLGLSVIVRVTLRDGTFHEDIGYGHIENCKGKAAAFEKAKKEGTTDALKRALRNFGNVLGNCIYDKDYLSKVTKMKVAPTKFNETELHRHSDFAIKKEEGKALPPPPVKLETAESIEDLLEDFDEADFAVVESDHPDEVVLPPVANGVSNDRAASVAPAPVPNHMQAPSRQMGRSTSTGSLRAPQTPNQAQSRQGPPTGYGNRPQAPNQPRAPTNPLAPSAPSAPQANGNMTTPGQAGNAAEPVGFFSARAVQQIPESALQGNNADAPLLLPAGQQAFNPKAESPSIRKTPGIDHSVSKPLARSGQHVPPTPSQQPSASGFTPVRPGNAGPGGGTGAPHLQLSQSRRIGAPGGAGSPLANRGSYRPPTMKRPLQQDGAVRPALVDVSNNGAAGNAPGGMGVDPKRQKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFD7</accession>
    <name>H1VFD7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_02020</name>
        <name evidence="6" type="ORF">CH63R_08909</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003234">
        <property type="protein sequence ID" value="CCF38940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155906.1">
        <property type="nucleotide sequence ID" value="XM_018303883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFD7"/>
    <dbReference type="STRING" id="759273.H1VFD7"/>
    <dbReference type="GeneID" id="28867990"/>
    <dbReference type="KEGG" id="chig:CH63R_08909"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08909"/>
    <dbReference type="eggNOG" id="KOG3162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082177_0_0_1"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF38940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="206" mass="23539" checksum="18A4639AF4996C89" modified="2012-03-21" version="1">MPPRLPFFSAVKAPSAFFPQIARPFSSTPAVAKSSDPISNLLNLDEKPKVHSTDRIRGLIKTGKARIDGVAAARKLTMLESLREKKVSDDYVKQMPRRWNAGEIYAPHDLSPVEMEKWRKSKRPNVDVVDLLGLNPLDHYRNFSIISEYMTPFGQIEHSKFTGLRPVNQRRMAKAIRRAIGMGIHPSVHHHPELLKKRFRLNASWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGI4</accession>
    <name>H1VGI4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_10199</name>
        <name evidence="13" type="ORF">CH63R_09564</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003439">
        <property type="protein sequence ID" value="CCF39337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156561.1">
        <property type="nucleotide sequence ID" value="XM_018304538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGI4"/>
    <dbReference type="STRING" id="759273.H1VGI4"/>
    <dbReference type="GeneID" id="28868645"/>
    <dbReference type="KEGG" id="chig:CH63R_09564"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09564"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1360315_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF39337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="201" mass="23354" checksum="A7803BDED4F13761" modified="2012-03-21" version="1">MTAAEYTDWCIQQNLQRDLDAYSSLDPAVQQDIQAKYRLLHERVKDAGLFDCPYSEYGKETCRYSMLFASFLVALNFEWYMTSACFLGLFWHQNMFTARDAGHGAITHNFTFDTIIGLAEYDPDIQNLPFFSTCPSFCKSLLSTYYENFVIVWDAAAEFLVQCQRWTYYPLMAIARFNLYLLSWLHVISSRSTSLGNSKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGT7</accession>
    <name>H1VGT7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_10274</name>
        <name evidence="15" type="ORF">CH63R_04717</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02003495">
        <property type="protein sequence ID" value="CCF39440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160938.1">
        <property type="nucleotide sequence ID" value="XM_018299692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGT7"/>
    <dbReference type="STRING" id="759273.H1VGT7"/>
    <dbReference type="GeneID" id="28863799"/>
    <dbReference type="KEGG" id="chig:CH63R_04717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04717"/>
    <dbReference type="eggNOG" id="ENOG502RZWZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_5_0_1"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF39440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="268" mass="28720" checksum="32EDAFFC48C1D0F6" modified="2012-03-21" version="1">MAETLQIPDEDAAWLSPHLPSESAIQSAGHQNRPFVTLTFATSLDSSLSLAPGVRTRLSGPESKAMTHYLRRQHAAILVGVGTVLADDPGLNCRIAGAGLDAQPRPVVLDPRGRWDFTEHSKVFEIARAGKGLAPFVLVGAAAIDSERQQVLEAHGGKFVVLDTQKAEPRFNWPSILSVLHDEGLDSVMIEGGGQVINSLLSPEYHQLVDAVIVTLAPTWLGRGGVVVSPDRVHTSEGTPMPAARLADAAWHQFGEDIVLCGKLRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGX4</accession>
    <name>H1VGX4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10302</name>
        <name evidence="3" type="ORF">CH63R_12478</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003520">
        <property type="protein sequence ID" value="CCF39477.1"/>
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        <source>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004489">
        <property type="protein sequence ID" value="CCF41100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154147.1">
        <property type="nucleotide sequence ID" value="XM_018304723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLJ7"/>
    <dbReference type="GeneID" id="28868830"/>
    <dbReference type="KEGG" id="chig:CH63R_09749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09749"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="207" mass="22249" checksum="3147FEB868614FA3" modified="2012-03-21" version="1">MGACSKEKRKKALRELQARGRKGTLSLVIFDVSDDDSIGAAAAKIQADFGRLDVLVNNAGIATTVLITRDSLRTAFDTNVFGAMLLTNAMTPLLHASKSPKIINVSLELGSITLKLDPANPFYKMPGEIHRLSKAALNMLEACQHVALEEVGGTVWAFCPGYVITDLTGDRENWKSQGAESSETSAQGILEIVQGKRDGNVGKFVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H1VR50</accession>
    <name>H1VR50_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative cell wall protein gp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_12627</name>
        <name evidence="6" type="ORF">CH63R_03478</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005587">
        <property type="protein sequence ID" value="CCF42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163269.1">
        <property type="nucleotide sequence ID" value="XM_018298453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VR50"/>
    <dbReference type="STRING" id="759273.H1VR50"/>
    <dbReference type="GeneID" id="28862560"/>
    <dbReference type="KEGG" id="chig:CH63R_03478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03478"/>
    <dbReference type="eggNOG" id="ENOG502QR47">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004835_2_0_1"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
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    <sequence length="637" mass="71403" checksum="4B20C9CE915E8FD0" modified="2012-03-21" version="1">MSGAQAGNEAPETSNKRRRTSGMYQRRRAVAACGPCRVRKTKCDNVRPACGFCQRNGGHCTYPDTSNDFSTFDPASLAILDRINHVVSLLETGPQPPMDNVGSAVPLPQSTLSPTSISGPQTSTSLALEEDPTHAPDNLPEDDAMIRFNIPDSAAASANCEAVLKWPIFRGLVPDVESFILEADDDDRESFDRPRPVNGCSLGRGVQEDDFTVLSKKFLAYVHVKNPILDVADFKAQVRDAVESGPRWDGPSCLVLIACALACLASPFQSELNLNGTPESVRSSASNSTDPDTAQAYYLAAKKRMGLIEPSLLQVQCLFFFAVFEMYTLHPLQAWFYFNQACVQFKSLLWRRSQRRNPHNISQKTRRLEQRLYWSCMKSECELRCEIPLPLSGITSLGYPDLFPSPPSEVASPAAQPSALDILEDDIHPEEEKSWFYYLAEISSRRMINRAISVFGYNGQQAWVQDVARVVEKCEEFDGHINVWCLHIPSQINWQNRDLSNNELVHFIQNRATSCREWIHRPFVYYVVHQPPDDPWMPRVMPLAEKCLELSVELLLDINLHHRHHGTWFMARAAMTRALLVLAAVKSGRFNQLPERWKQAVETATLALQRWYGEAPDLLRAASVLEGVIGQVIGTGG</sequence>
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    <accession>H1VSG9</accession>
    <name>H1VSG9_COLHI</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005904">
        <property type="protein sequence ID" value="CCF43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163700.1">
        <property type="nucleotide sequence ID" value="XM_018295338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSG9"/>
    <dbReference type="GeneID" id="28859445"/>
    <dbReference type="KEGG" id="chig:CH63R_00363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00363"/>
    <dbReference type="eggNOG" id="ENOG502RF0E">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4799055at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497730" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="126" mass="14193" checksum="E7E56BB6C0DBCF5F" modified="2012-03-21" version="1">MKNLLLILAGVASLTTGSAVVNPQGAVYKVREAIAEKERRNDDHTQTRAAEGTVPLHRRECEISCPINLYWCKYVPYNYKCDRNGKLQWDRRNEDCEQATYGCWCGCDWRAPGIEKKDGPGSAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSS0</accession>
    <name>H1VSS0_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Pre-mRNA splicing factor ini1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03034</name>
        <name evidence="3" type="ORF">CH63R_03054</name>
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    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005979">
        <property type="protein sequence ID" value="CCF43278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162845.1">
        <property type="nucleotide sequence ID" value="XM_018298029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSS0"/>
    <dbReference type="STRING" id="759273.H1VSS0"/>
    <dbReference type="GeneID" id="28862136"/>
    <dbReference type="KEGG" id="chig:CH63R_03054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03054"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_2_0_1"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="110" mass="12390" checksum="8A1B1FB6B0154B01" modified="2012-03-21" version="1">MSRHHPDLVMCRKQAGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKTNRTATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTS0</accession>
    <name>H1VTS0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_13276</name>
        <name evidence="10" type="ORF">CH63R_02013</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CACQ02006240">
        <property type="protein sequence ID" value="CCF43628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161804.1">
        <property type="nucleotide sequence ID" value="XM_018296988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTS0"/>
    <dbReference type="STRING" id="759273.H1VTS0"/>
    <dbReference type="GeneID" id="28861095"/>
    <dbReference type="KEGG" id="chig:CH63R_02013"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02013"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_11_1_1"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556310" evidence="7">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="43"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF43628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="249" mass="26787" checksum="A18E26DE4A4FA45D" modified="2012-03-21" version="1">MYSSALSATTAVLALAGGAYASPLSRRQSPPVGQIISQCTQTGVVALTYDDGPFTFTPQLLDILAANDVKATFFVNGNNFANIEEGIGPATINRMKNEGHLVGSHTYAHPDLNTLSSADRIAQMTQLEDATRRIAGFAPKYMRPPFLSCDEGCLSDLAGLGYHVIDTNLDTKDFENNTPDTTHISAEKFNNELSNDPASSSAIVLSHDVHEQTVISLTQKMIDTLKAKGYRAVTVGECLGDAPENWYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VV05</accession>
    <name>H1VV05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Class V chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03226</name>
        <name evidence="4" type="ORF">CH63R_01189</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006590">
        <property type="protein sequence ID" value="CCF44064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018296164.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VV05"/>
    <dbReference type="STRING" id="759273.H1VV05"/>
    <dbReference type="GeneID" id="28860271"/>
    <dbReference type="KEGG" id="chig:CH63R_01189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01189"/>
    <dbReference type="eggNOG" id="ENOG502T476">
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="Ecp2-like"/>
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    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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        <location>
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            <end position="273"/>
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    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="107"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF44064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16009.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="273" mass="29115" checksum="B6C44E87DB9228D9" modified="2012-03-21" version="1">MTKVTSALISLLAVFARFTPVAPFYIPSFLNHTNGTNTTYHQPRPPIPSPTTALGRPETPCTGAGVGVGVGQSLPSTMPASLGTDIETETQGPTFYRGSEVWRDEICGVSSFVGVTSAISALTSDCTALADDAAKERYLWYANGFTDNTTLLAIRNHGTCSIGIRPPHADVMANIISGWYVGGMDVAQIVRTAVRDYDVDGLMGATGMMHCEISSAANVDVQWAIFGPDEQAQAGWWVALPVPSSAGRRQPVGMAVLSAVAVFWQLFFWHVVS</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
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    <name>H1VVX7_COLHI</name>
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        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor</fullName>
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    <gene>
        <name evidence="7" type="ORF">CH063_03320</name>
        <name evidence="8" type="ORF">CH63R_08797</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CCF44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018303771.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VVX7"/>
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    <dbReference type="KEGG" id="chig:CH63R_08797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08797"/>
    <dbReference type="eggNOG" id="ENOG502SJWB">
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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            <begin position="6"/>
            <end position="38"/>
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            <dbReference type="Proteomes" id="UP000007174"/>
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            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="535" mass="60166" checksum="D7987AA71932BD53" modified="2012-03-21" version="1">MRYSTACSACRARRRKCEVPIGGGQCTYCATQNIACSRAGSIIQPKATPISPVSATSMTPKTPTVTEIMIATPPGITPSAAVADKALCFELVELYFKYIHDQLHSLFHRPSFMLDLHEGTAPLVLVYGMMALSARFSSNPIFNGISPISRGELFANEGNLLLNLRDVSLTSIQACVLLGAYSIVEGEAGAETVFYSAACRIANYHDLPNLPTPDPLQREIHIRVYWSLCMIDVWSSTGVNLPRLMNRRMDVPLPMNESTFLNMTRATNNHFDFILSPNREDSLIAQMIKLNSILMRVNDAIKSLTSDVDVTNIDETVSQLSQELEAWEVELPPGLRDTPSNLHSFAAQGLGRIFIAVHTGHYHYSQLLYYQYLDEVQRFPTSPTAQMFARKCKENAISMSRIIDLANTTPGCDAKFNMLGHIIVITSSIFIHTLLFETDEAEIANARATLERHFNTLVALRVYWPALEVCFARLRTFHELCRKSMNTSYRMDRWMLRFLTEFARPIDEKERDEDGLMDLDRWSVGNIGISPENWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYD6</accession>
    <name>H1VYD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_14393</name>
        <name evidence="13" type="ORF">CH63R_12007</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007566">
        <property type="protein sequence ID" value="CCF45248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153822.1">
        <property type="nucleotide sequence ID" value="XM_018306981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYD6"/>
    <dbReference type="STRING" id="759273.H1VYD6"/>
    <dbReference type="GeneID" id="28871088"/>
    <dbReference type="KEGG" id="chig:CH63R_12007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12007"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF45248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR05304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="155" mass="17857" checksum="44B97F7194368E80" modified="2012-03-21" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMAKKRKKKVYTTPKKIKHKRKKTKLAVLKYYKVDSDGKIERLRRECPSDTCGAGVFMAAMNDRQYCGRCHLTYVFDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYV8</accession>
    <name>H1VYV8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS quinate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_14511</name>
        <name evidence="12" type="ORF">CH63R_12458</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Shenoy N."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">IMI 349063</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="NPHP3-like_N"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
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    <dbReference type="Pfam" id="PF24883">
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12781.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="939" mass="107063" checksum="94358DA943A240D1" modified="2012-03-21" version="1">MAESLAALGVAANIVQFLELGLKATISIVETYRSINDDGWASRNADLDSMAKDVQLCFGRLQEDADVKLDPSMKSLLQRSIDTADELRSVLLGLVMDSSRRHRMQKWAKFKASVAAHFKKGKIDEIQARLAEIKSHIFERLQVLLYDHRLSLSRSMHSLEEASEGWNRATEKRLNALAQDLGKLAEESQSAAEASSEGLRVFAETWARVSEEAKNQDTVLAILASLRFAQIKERQSEVPKAHRTTFEWVFSEESPVDFSAWLLESSGLFWITGKPGSGKSTLMKFLLGHERTMLLAEGWAKTEPLIIASHFFWAVGTEIQKSQEGLLRTLLFQVLVNCPGIISMVCPARYASPFRRLDTWSIEELSEAFIRLKDIRPLPARILLFVDGLDEYKGNKGDLVRFLRSTSESPYIKVCCASRSWPVFLNGFKDVSGQIRMHELTANDMVCYVRDTLEQHSFFEALRKRHEDEAENLVRDIAERSEGVFFWVFLVVKSLLRGLDNSDDLGILQRRLSEFPSDLDKYFQRMLDTIENVYKENVSLVFSMLLLANSPLPTVLFLALEDLVETCKKERDHKERNQSKFFPSLMAWRRDLAPKTLDTFTLNVIHDAFGLKHGQEKQLACGDLEESLVKTKQDQILAQCRDLVQAWEIDGGISPYHLRLGFLHRTVVEFLQQSKGNQWHSTLPAERYLLGRSCLAFVTFLGGVPLHQTEEFVLRLLCTIHGNTARLDHLNDWLLEGLLLKFGDYPSTTAADPLRRRLEGVVIQEWLRREYPYETPGRLRDFCEQYFHWLLHESGHIEVGDWARISWSRMIDLETLERVLGVDGLVSERRRELSVAFLDFLERLCASSEEDKPRNAFDVCKVLIQHGIAGYARGNGKTMPFGPDSKQTRSGDPEMLALTQVTTLERLRGNKVFSEEELLELGEAFPSGSIARHKTTVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1W422</accession>
    <name>H1W422_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polarized growth protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04091</name>
        <name evidence="4" type="ORF">CH63R_05364</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009501">
        <property type="protein sequence ID" value="CCF47235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158189.1">
        <property type="nucleotide sequence ID" value="XM_018300339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W422"/>
    <dbReference type="STRING" id="759273.H1W422"/>
    <dbReference type="GeneID" id="28864446"/>
    <dbReference type="KEGG" id="chig:CH63R_05364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05364"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021690_0_0_1"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="579" mass="64188" checksum="FBE359AB72DDE5F3" modified="2012-03-21" version="1">MSHVALLRHGLRLLLPLALISTFYLYLYPVFLGCAFPVPPTAARASSSSPSDVDVADTGIAAFLEAARHHVSLPIPLRPSDARPAPFRLLALGDPQLEGDTSIRKHSGPIFPHARSLWSHVTFQSSHSLRQRIRQSLHDAVDVFLEDLFDELESIRKRIDLFGNDFYLAHIYRTVHWWTRPTHVTVLGDLLGSQWIGTEEFRRRGRRYWDRVVRGAERVPDEAAAYPAMEYDLTDYLSPSGEPSLEWPRRVINVAGNHDIGYAGDINQDRFGRFERLFGKANYELRFELPVQDPNVNATLVDDEENPESDRLPPEIRVIVLNDMNLDTPAKDATLQDATYAFINSVIETSAAVEYSGHFTVVLTHIPLYKPEGVCVDAPFFDFHGEHDGGGVKEQNLLSADASKGFLEGIFGMNGNKEAPGNGNGRRGVILNGHDHEGCDTFHYINQTDGDQSTDRAWQVETWATAKGRGVVGAAGVPGLREITVRSMMGDFGGNAGLLSAWFDESTWSWKFEYATCALGTQHLWWLIHIVDLVTLVAAAAYVVLSVLEASKQDLVAVASSSSVEEKKKLAQNGVAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1W598</accession>
    <name>H1W598_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">About the patent is no further information available</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04236</name>
        <name evidence="4" type="ORF">CH63R_06821</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009989">
        <property type="protein sequence ID" value="CCF47662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159646.1">
        <property type="nucleotide sequence ID" value="XM_018301796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W598"/>
    <dbReference type="STRING" id="759273.H1W598"/>
    <dbReference type="GeneID" id="28865903"/>
    <dbReference type="KEGG" id="chig:CH63R_06821"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06821"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="333" mass="36038" checksum="B2D286BD3B92E2E4" modified="2012-03-21" version="1">MFPIQLNRYTEAHKPENLRGPGDGRPTALQIVQDEGLVGKLAGRVALVTGVSSGLGAETLKALAATGATVFGTARDLDKARATLGDLANATNVRLLKMDLASLASVREAAAEFRAQSDTLNLLVCNAGILQLDEKARTADGFEMHLGVNHFAHFLLFDLLKDIIVKSSTPGANSRVVTVTSSGHRIQGIRWDNMALEGEYDASKAYGQSKTANLLMAVGVDRRFEGVHGYSVHPGTALTGLQVEVQEQMEAMKQNDDTYRTFKSADQCAATTVLAALSRELEGKGPLYLEDCEVKGETKENLGWGGEGYARWAWDKEEDDKLWELSSKLVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQF1</accession>
    <name>A0A1B7XQF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150514.1">
        <property type="nucleotide sequence ID" value="XM_018309542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQF1"/>
    <dbReference type="GeneID" id="28873649"/>
    <dbReference type="KEGG" id="chig:CH63R_14568"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14568"/>
    <dbReference type="OrthoDB" id="10420784at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR01996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="145" mass="15506" checksum="4FEF1EA4E9A1A782" modified="2016-11-02" version="1">MKAASRVDLATISPSMCQRISATVNGNPEHFCAELERRRQQSQRDQEKNNALAMNGTARSRQQERESDRLGGNGGGGGGDVIGGGIKGGGGGGGGGNAVSEFASVQEIDRKMDILLGAQEDALQTVLHHELEIKRLYWLKQRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQG7</accession>
    <name>A0A1B7XQG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150492.1">
        <property type="nucleotide sequence ID" value="XM_018309520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQG7"/>
    <dbReference type="GeneID" id="28873627"/>
    <dbReference type="KEGG" id="chig:CH63R_14546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14546"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="170" mass="18292" checksum="2D9E3667C5319307" modified="2016-11-02" version="1">MQDSESVRRVCDQSTTSVPLPTHRPLDNRCVADHSKHPRDGNQASSDPVHEKAAVASPPSHTTNMTTSVTTADTTRTTTATAPVLEACHQTPSSQDFVAACRHLASLAIAIPRIDASYIGMLPPPRGSTGHLLRETLITCVEAYLDYIDNESDKVASPPCNNADNNVPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQN9</accession>
    <name>A0A1B7XQN9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150596.1">
        <property type="nucleotide sequence ID" value="XM_018309624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQN9"/>
    <dbReference type="GeneID" id="28873731"/>
    <dbReference type="KEGG" id="chig:CH63R_14650"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14650"/>
    <dbReference type="OrthoDB" id="4731103at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600978" evidence="1">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="340" mass="37721" checksum="85C41EAD888B4331" modified="2016-11-02" version="1">MHWSLATLSWLLVASASAIPLATQHSHGLTSLAQTKRAATDVSLPEWNDVEDDNDGGAHVQLPNNGSLVGRDIKKGWYSREEAAMLQKESEVDVNFFNLLDTLDSLGQLLDRNRIPWAIAGGLALKIHGQPHRYTSDIDIVVQTTMPKLQTALSKDKKFIVPGAGWPSDAHLRVYHNQGSTAKPKYIEVDMIIAGKLTTPENLRANSKDFQKETKAKKPLTIHVMRLGKIFKSKVYALAADHRNKDDKDMKDISWIIEKTPGALVNVQQDLTYDLRQLVIMHLVRLRSPLLNKARELLGVDAGARLHSVPPPQIVGVPPDQQPGFVSWLFDGTPGHTVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQU1</accession>
    <name>A0A1B7XQU1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150639.1">
        <property type="nucleotide sequence ID" value="XM_018309396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQU1"/>
    <dbReference type="GeneID" id="28873503"/>
    <dbReference type="KEGG" id="chig:CH63R_14422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14422"/>
    <dbReference type="OrthoDB" id="4810579at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="38440" checksum="5F96BA71753B5E07" modified="2016-11-02" version="1">MHCLAENIDDPLYQLMLMITLTLCASSETPQVAPKQHAFSAAPRRKDHRLLALALVTRMMWFLYPKCFPWQKNPGETAYDVAEMTKKIEHRGCSNRMLRALGWIVVPNGRPNPRNTEVSLQSPSILLDLARALKTAVRRPEEFIGLPAKALDSIYANIGDPAVHNQDAPNRRVVPGRPQPGPLPPIDAKPEEEVANPAAVEAPSRRDGNRDESRLTAGEAVADEVHPNPHHLAGPLLHHPLGEVGARAHPVDHRALSFQVVAQEVNGVSVCRRPSKGSAVFSNSAANQLDVVEEPELKFRCSTPHAYKKALLGIQELRDWNYAPYLDGAVVVYILYHDTRPPASETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTE6</accession>
    <name>A0A1B7XTE6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biphenyl-2,3-diol 1,2-dioxygenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151555.1">
        <property type="nucleotide sequence ID" value="XM_018309237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTE6"/>
    <dbReference type="GeneID" id="28873344"/>
    <dbReference type="KEGG" id="chig:CH63R_14263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14263"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43279">
        <property type="entry name" value="CATECHOL-2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43279:SF1">
        <property type="entry name" value="CATECHOL-2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="194" mass="21685" checksum="57EF4B11DFAC0B17" modified="2016-11-02" version="1">MTSHSSQVDGLVKSPSKVGHVVFKTSNFRGMVDFYIKFLGCVVAFENEQLSILRFDDDDDHHRVAILYLPDLKPTDPQAVGLEHVAFSYSTLPDLLAAYQTHKSNGISPFWCVNHGPTTSMYYKDPDGNGVELLVDNFDTIREANEFMASRLFAENPIGTEFDPQDLVQRLELGESESSLKKRVEIGPRNALGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUE2</accession>
    <name>A0A1B7XUE2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CH63R_12512</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151903.1">
        <property type="nucleotide sequence ID" value="XM_018307486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871593"/>
    <dbReference type="KEGG" id="chig:CH63R_12512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12512"/>
    <dbReference type="OrthoDB" id="5245018at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="24">
        <location>
            <begin position="466"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="970"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="23">
        <location>
            <begin position="1274"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1312"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1332"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OBR03385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1357" mass="158851" checksum="5CDAE6C009F0DFF6" modified="2016-11-02" version="1">MERRAAEQLLELRRTRSSTRSKSPNLKIKQEIRQRLRNLDPYDRIKLQEYEIDEGNDIDSDEPLASQTYPSTGHAPLNQRPNVDKTHNNQEVRFYGTEDVDANNRPEVQIQEKPLFGDDELLELTHKRHYRIFWADCIYDECKTHLRSKEEYAFYPRRQGREPIPKAYQDSELNTWEVKEYLTKWLCFQPSPKHPMPCVNHITKHWSDCMFDKCKYHYEGKAQAWRTQIKGKNSNDRHLFLEAIIDGQPTQVMIDSGAQANFMSPRLINQRKIAWRLKDEPYALQNVEGETVEYDGGTISKETAQLSMVIHGRQEQLIFDITKIGQLDVILGVPWLRKHDPDISWKANQLRWRDSATEARCMPQPPGEHRRQRYVAYVKRIEPMKDERFESFINDQREEERLSPIPAEYRSYKKLFAEELETGLPEHGPWDHEIPIKEGEHPKFHKLYGLNENQREELDKYIDENLRKGYIRPSTSPAGYPILFVPKKNGKLRLCVDYRQLNDITIKNSYPLPLITELRDLLYGAKWFTALDLKGAYNLIRIKEGEEWKTCFRTRRGNYEYLVMPFGLTNAPASFQTMINHVLREYLDVFVVVYLDDILIFSPTLEIHKEHVHKVLQKLQEAKLLVEPEKSVFHSQRVDYLGFTITPGEIRMDDKKIAAVKDWPRPQNVKDIQSFLGFVNFYRRFLKGYSDKINPLIKLTRKNTTFEWTDEQDKAFEDIKQQVLSEPVLMIPDPRKPFELETDASDYAIGGQLGQRDEEGRLHPCGFFSKKLSGPELNYQIHDKELMAIIEAFREWKPQLSGTKHEVKVYTDHKNLAHFTTSKALNKRQIRWSEFLSEFNFRIIYVKGTENGRADALSRRPDHETPVPDETLVILKQDDKGDLVPAQKLIMIGTRVNTSTTGRMTPEQIREIHSARAHGHQGVTKTFKRIRQHYDKKVTRAEVASAIKDCEMCKKSKNSPHKPYGQLQPLPIPPEAWHSISLDFIVKLPKSREPLTKTWYDSILVIVDRLTKYAYFIPYLESSTAEGLAYTFLKYIISNHGLPKEIVSDRDKLFTSKFWKSLISQLGADHKLSTAFHPQTDGQTERINQILEQYLRCYVNYDQDNWVPLLPMAQFAYNSAIGESTLHSPFYLNYGFQPTAYGEPRQGPRALKAVADYNKLRELQENIAKDLEFVRARMKKYSDPSRMTGPSFEEGDSAYLIRRNIKTKRPSDKLDYKKLGPFEIIQKISDVNFKLKLPDTMKIHPVFHIALLEPAPRGSHTEDCIIVETHEPEYEVERIIDHRNENGHDEYLIKWKGYGHEDNSWEPVKNLQHSQQALQQYHEKDSRDLAPQSPTLRPENSSQTPRRHPRRRDLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWF6</accession>
    <name>A0A1B7XWF6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_13212</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152603.1">
        <property type="nucleotide sequence ID" value="XM_018308186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWF6"/>
    <dbReference type="GeneID" id="28872293"/>
    <dbReference type="KEGG" id="chig:CH63R_13212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13212"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601136" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR04085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="362" mass="37614" checksum="79462240264DC0A3" modified="2016-11-02" version="1">MKFLPIIAGLSALAAAAPAEIDTRASCTFTDAKTAMSKKTSCTDIVLNGISVPAGQTLDLTGLKDGTRVTFKGTTTFGYKEWEGPLIAIGGKKVAVVGASGNSINCQGERWWDGKGGNGGKKKPKFFKVKINDGSITGLNVKNTPAHGFSINSVSNLKVQNILFDNKDGDSKGGHNTDAFDVGESTNINISGAKVYNQDDCLAINSGTNIVFEKGYCHGSHGLSIGSVGGRSSNTVKNVVIRDSTIEKADNGIRIKTIAHKTGSVSGITFDNITLKDINKKGIVIQQDYENGSPTGTPTAGIPITDVVVRNVKGTVAAKGTDIYILCAKGACSNWKWSGVSVTGGKTSKECSGIPSGSGAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWL5</accession>
    <name>A0A1B7XWL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152663.1">
        <property type="nucleotide sequence ID" value="XM_018308246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWL5"/>
    <dbReference type="GeneID" id="28872353"/>
    <dbReference type="KEGG" id="chig:CH63R_13272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13272"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="125" mass="14305" checksum="F31BE001874B60B8" modified="2016-11-02" version="1">MEQLYSLPKHQDWAEERAWWGPEPVTWGYNVDVFAELFLRPGMKREASLNVEFAHFLMLSGRHPAEHQSRMVEALDYWEREGQRCPGMVLRGALGESVYGDVARAGPDTTCFAGVQVWYMCPAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWT5</accession>
    <name>A0A1B7XWT5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152751.1">
        <property type="nucleotide sequence ID" value="XM_018308334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWT5"/>
    <dbReference type="GeneID" id="28872441"/>
    <dbReference type="KEGG" id="chig:CH63R_13360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13360"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6542" checksum="9768CE192D0BE18D" modified="2016-11-02" version="1">MDVADNLNKRASSGSKAVISVRSDWKLQVASEGCAECRGGRQEARPTMQDGLRNRGEAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWY0</accession>
    <name>A0A1B7XWY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152786.1">
        <property type="nucleotide sequence ID" value="XM_018308369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWY0"/>
    <dbReference type="GeneID" id="28872476"/>
    <dbReference type="KEGG" id="chig:CH63R_13395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13395"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="116" mass="12590" checksum="EF1401E611340B9A" modified="2016-11-02" version="1">MGPSDLARFQQLRHGVPRGDLVASSASRTHDLKSNWAFLRLFAKVLAMFTQSRPGITSHIGKSDVQSGFFDIISAKVDVLFALDDTMPVTAGVRNDAKPASDGVVEQHLVANRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXT2</accession>
    <name>A0A1B7XXT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153078.1">
        <property type="nucleotide sequence ID" value="XM_018306237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXT2"/>
    <dbReference type="GeneID" id="28870344"/>
    <dbReference type="KEGG" id="chig:CH63R_11263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11263"/>
    <dbReference type="OrthoDB" id="4822697at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="240" mass="27210" checksum="43AC22C748784BCD" modified="2016-11-02" version="1">MCVGFIINGTSQDNSYFRSSTRFHRCFNFLLRSAQVSTASQPGVLSCAKQPRPRYKFGPKVPTMTNAHPPALARVSPPVRMINPDHSFTFVNLASKSFELVQHTIPTSPDIRMVHELPDSTQLGKDGQLIMSWTKGCYFGKSGRDDVFLCWQEMEALQSFCVGIESPERGFFKPIRSHYKIKYNDGTTAKDWFRPSDNPGDPYTFPNTMNVDIVVTSHSAKDQLELEITIRDRNPPELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXY5</accession>
    <name>A0A1B7XXY5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153128.1">
        <property type="nucleotide sequence ID" value="XM_018306287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXY5"/>
    <dbReference type="GeneID" id="28870394"/>
    <dbReference type="KEGG" id="chig:CH63R_11313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11313"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="366"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="496" mass="54206" checksum="48F7787FCF75F9B6" modified="2016-11-02" version="1">MTKSKAKKRKQTAQAEQLPRKTIKTSITPPDSSDDNSATLEPKSLQTVISDEELDIAIETLNTLAKYPNLIKSKQCRDLRVAVYEFRQNCASGVNNAPGTNLGLTARITGALTDEKYDDARILLAEMRIRGQEPKLGALCRWVRDLDVISGLSTLPEGEGDGIFIQRSERDKQRLLVLDAVLRACGHSDSNPKAVPLPLSSTPGIALQETWDLRSSTPSQQVYASVLDKTIFDSAPRNLAASFRVIERTKGPLRKPPNHHDALLYTSAPNTIPLAAEHPPVTSCSHPVVPGLGFLKGVLSTDECKAIVAAGEAVNFLPDAPLREDGDISILAHNVYWVVDTAFHDALWARVSPFVPASVGGRQVRGLNRRFRVYRYVPGAEYRAHIDGAWPPSGILPDDTYVYDASPEGKGQSSLFTFLIYLNDEFEGGETTYFLPAAREGTLNAYPVRPIMGGVAIFPHGDARDAPLHEGTGVRKGAKYVIRTEVEYDIKPSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY08</accession>
    <name>A0A1B7XY08_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153139.1">
        <property type="nucleotide sequence ID" value="XM_018306298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY08"/>
    <dbReference type="GeneID" id="28870405"/>
    <dbReference type="KEGG" id="chig:CH63R_11324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11324"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="165" mass="17954" checksum="04C9745600DAAE22" modified="2016-11-02" version="1">MEHTYSSLSGQLAQPYETVVVLLLPARFRATGRVDSRLGDKRIGGGGGHRTDPKSSALTEALTKTVAIQSTYESPRETPIAWHPSFDRAWAVHLLHEEETRATHDTSPVMVDIAPGLIIPITPDVLSPITNRQEYADDATLPPPPLDRTKPDASPYTAAQSHVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYF7</accession>
    <name>A0A1B7XYF7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153313.1">
        <property type="nucleotide sequence ID" value="XM_018306472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYF7"/>
    <dbReference type="GeneID" id="28870579"/>
    <dbReference type="KEGG" id="chig:CH63R_11498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11498"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="251" mass="28733" checksum="EC2A3D08F01A8786" modified="2016-11-02" version="1">MATMVSTGSPTMFHIRGRRRLPLDRAGCVAGLLCLEAVVVVGALVLFGVAYPDRLRSRLWRNGGEEGWCSNPRLRIYFYANHEESPEIPLVWSQRLTTSNMATAVLSATVFFARLTIAALQYEARWTNLMYDVLLAFLWARSAATQNGPDFTDPQHLSERPWYLVRSCDEAWAQNRGWCRIAKWEFSWAILAAAFYAARIVVALGWSTYELGKRDGMKSGREMDLTLEQWTGDEKKWVAAYKYEIEEEDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYY4</accession>
    <name>A0A1B7XYY4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAP-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153506.1">
        <property type="nucleotide sequence ID" value="XM_018306665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYY4"/>
    <dbReference type="GeneID" id="28870772"/>
    <dbReference type="KEGG" id="chig:CH63R_11691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11691"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="432" mass="47295" checksum="C6D3DDF8EF4B315F" modified="2016-11-02" version="1">MASINRSKKGLSQSIHNPQADEEVQLRPRHFIVREGSAIVPLIPVDLLPTHLEIHGVPRQMNIEETTGMSNLGTFPKPKSQLQLYTVSFANDVSGRSVDNLCRDGLHTLNGDEPLEHLDWPHDPAPDPAIQAPVARWITDCGTEDLQSAVSRPAPTKEKPQPTATRVLDWAEDTESVSTDNFTATDEDPPTSSTFNTQSNPRQVPQAQRPSVTKKKEKSAVEIAGRMLELSRTQHAIRQGPPSQTNTQTNGDGTAKPPKPGKQKVPRPPGSLCRHWCQTGQCSWGIECRYTHQMPVTLEGLADIGLKELPGWWRRAAGLPVEGTIDIRIFAATAGNGKKSPSPALTAGDLSLIPTHPSKKTRSKVDKEERKMAEEVHMVRLGFERAQSTAAYPAVVGAGSSKKKPALGQVQLRMQTEKDQPRSGEVEKLVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZR4</accession>
    <name>A0A1B7XZR4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_11951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide lyase 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153766.1">
        <property type="nucleotide sequence ID" value="XM_018306925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZR4"/>
    <dbReference type="GeneID" id="28871032"/>
    <dbReference type="KEGG" id="chig:CH63R_11951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11951"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053868">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039513">
        <property type="entry name" value="PL-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052052">
        <property type="entry name" value="Polysaccharide_Lyase_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088">
        <property type="entry name" value="PECTATE LYASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40088:SF1">
        <property type="entry name" value="PECTATE LYASE PEL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14592">
        <property type="entry name" value="Chondroitinas_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22842">
        <property type="entry name" value="Pel9A-like_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601210" evidence="9">
        <location>
            <begin position="18"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Pel9A-like right handed beta-helix region" evidence="10">
        <location>
            <begin position="140"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="438" mass="47425" checksum="321BE31B8609A80B" modified="2016-11-02" version="1">MLSVFKFLVAAAPAVLAADIFVSTDGSSSGSGSISSPYSSIQDAVDAASPGDTIRIRGGTYKPSENISFRKSGTSSSPYTVRAHDGEEVILDGDNLFGTPVEEYEGSLPSSKRGIFHIRGADYWRFYNLTFTKGPYGLYVEDSSNNYFERITTHTNYESGMHLQNKISNTEIVFLDSYFNYDPRKNGRSADGISLKEGSGDGNIIRGARIWHNSDDGIDLWQFGSPVTILDCIVFENGFDRWDVGSKHEADGHGVKLGGGSSASDRTPVDHVVKNVISFGNKRRGFTDNNMPGDMTFERNTAYKNGEEGFNTRSSSATYTGNLAAENFGTTDTDDQYYFIDGVTSKGNSWDEGQTWSDASFVSVDTDSVTGSRAADGRLPAIVKDFLVPVDGEELGARVGDWAAGDASFSGASAQLIEGETEVDSIGCSTKLRRVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZT2</accession>
    <name>A0A1B7XZT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153784.1">
        <property type="nucleotide sequence ID" value="XM_018306943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZT2"/>
    <dbReference type="GeneID" id="28871050"/>
    <dbReference type="KEGG" id="chig:CH63R_11969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11969"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="202" mass="22174" checksum="82C676821591D21C" modified="2016-11-02" version="1">MEFSSSTPPPPPPLPLPLPPLLSAIPGGMRFTEATDVFFHGASHGEQFRFPPESWRLFQDRSLPVSIDAADRYREAIHEYFAEVNIFFPLLALEDIVATFDEVVASEQTAGTHVSPLVAPSRYCLLLLVLCLGSFVCTGANRISLDETAGRSGGQHHRPSSSSIFADFPGLDELLWRKSRLLLGFVSSEITLEAAQCTMLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZX7</accession>
    <name>A0A1B7XZX7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc knuckle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153840.1">
        <property type="nucleotide sequence ID" value="XM_018306999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZX7"/>
    <dbReference type="GeneID" id="28871106"/>
    <dbReference type="KEGG" id="chig:CH63R_12025"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12025"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="816" mass="93194" checksum="B97F07FC8C2C5392" modified="2016-11-02" version="1">MPRLKKPDGSLCRDDAENAVCFRQSIWPETSTGGRPDPLPLPNLPTGRAEHDSSPIFDEDEVSKVCRGLEYGKGCGPDGVPSDAIKYAKAPLIPYLVHLMNACARLSYHPDEFKTSKIVALKKPARSDYSLPKSWRPVALLSCIGKVLERLMADCLQQLAMKHNLLPGTQFGAARRCTTKALEYLLTPIYKSFIHPGFKKAQEIFKWLCTLLSLDIAGAYDHVRCQELLRILADKGIPAWIIHYVRSFLSARRSRVHFPGFVSDDFWVNIGIPQGSPLSPILFVFFTSPMLEKFKQENPAIDIVIAMSYVDDTYILVTSPSYKTNCEILTKWHDVVMGWAGPIGIRFDPSKYQVMHFRRSRTTSDYPDDMPAIVGLTKKNNLVPEERDPADENGVEDKRLTHLRILGLLVDHRLSWDAHIAHIEARVRAKMSCYNRISGSTWGVTLIDMRRLYYTSVRTIIAYAAPVWFVHFEGCGSHLQIRQKLVHKLQVLQNFCLRQISGAFRQTASMVLHKELHIDPIAIYLQRIAMSHRLRTLNTQEHKRLMESQQQLYPGMRSTAVFDAHPYKKAYDLAEAFLVTIRAELYHVKFPVPAAEIWGNRKSRNEYINDYAERQASTMSGMLWDQYLNRRNKASRTLFNVRPVAAKGEWRKENLECYEGLKKAQSTILIQCRTGVIGLNSFLKQVKLSETDMCPCGTGVHTVSHLLYKCPSLAEARVHLPLFNKNLNKPDPTNFKKRAGIRDKLGKTYKKRGKTFTKPVKPNRKPYNDLTTLLTDHAHVVTEWAIRHFGLEQFEWTNQHLLIGPSKKYDSIFEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0D5</accession>
    <name>A0A1B7Y0D5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153996.1">
        <property type="nucleotide sequence ID" value="XM_018307155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0D5"/>
    <dbReference type="GeneID" id="28871262"/>
    <dbReference type="KEGG" id="chig:CH63R_12181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12181"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="107" mass="12064" checksum="21C76616346D86D6" modified="2016-11-02" version="1">MLCVLLQREFMTKKPFVSMVGSFETGFQTTELRSAFETIQIYRTTFDQPEDTSVAAKAPSTYAGKPSTEIDNAWRILVAPTVLYLQENEIGEYKDKTVKTDKGWVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0E5</accession>
    <name>A0A1B7Y0E5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EC45 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153979.1">
        <property type="nucleotide sequence ID" value="XM_018307138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0E5"/>
    <dbReference type="GeneID" id="28871245"/>
    <dbReference type="KEGG" id="chig:CH63R_12164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12164"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601241" evidence="2">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="118" mass="11512" checksum="8150BB4303DDCA2B" modified="2016-11-02" version="1">MKISVLFFTSALVAGVLAAPIGKTAPADAINIVNDDIVEAPVNDVNQIEKREKMFEGGGGRGGGGGGARGSGGGGKGKSKKPETGTGGSVGNGGSGGMSKPKEPVCKGSHTDSIRVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0X4</accession>
    <name>A0A1B7Y0X4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154151.1">
        <property type="nucleotide sequence ID" value="XM_018304727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0X4"/>
    <dbReference type="GeneID" id="28868834"/>
    <dbReference type="KEGG" id="chig:CH63R_09753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09753"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="2">
        <location>
            <begin position="297"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="482" mass="54529" checksum="B9B6E6AD61B1B2ED" modified="2016-11-02" version="1">MVESKTPPEKPPPRNRHNSFSSLPPELRLTIVDLLVASADSARHEKAALASVCSEWRAVVEKSTFQSLLLLEGDGHQDVRAFHRIVHGQRRRLVKNLALHIMLGFYGCEGCYREESGEEVDANNWRFTRAVRSLWSCLSRWPVAGDAAMTLEIKCGALSDKQHFFRDAKDGGRHLLYDQSLQGRRFSLWGARKRLLGTLLDFVQDCGAPPLLPTVRVVRRLRVNKSLYRSLSAAALRVLFESLVDLTVVCYQPWRGVDVQGQRARDDANTALFRTLGPSACGVHLWEAQSPELHGDKYRPKPPNAKLVDAVVEASYRLRDVTIYHAIDGADFFRLASARPTHPMPAWPNLRFLVLSCRHLALSSAQSEAYDLLLTAARAAMRMPRLGCMELWWGEVNGGYIFRYRVDQDATTVTVVATSEAAPHPDVLKAWRRVAYENTRHQLQRRAVVLKADAMVSSTAICRFLWLFLWLRELLQGDAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1Z6</accession>
    <name>A0A1B7Y1Z6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_10154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154552.1">
        <property type="nucleotide sequence ID" value="XM_018305128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1Z6"/>
    <dbReference type="GeneID" id="28869235"/>
    <dbReference type="KEGG" id="chig:CH63R_10154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10154"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="278"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="547" mass="61005" checksum="D5DFB5C8B4B38042" modified="2016-11-02" version="1">MTDAGGKYYSWEKDRLIARIRQLEHELAKRDAAASSKSAGPGPGSGTATVDAAPPPAKKRKKDKKMDASRYSSRFIALKFAYLGKRYGGFEYASSASLPTIEGELWNALTKACLIFPEDPEVVNFDCCEYSKCGRTDRGVSAFGQVIALRVRSSKPLPKKPEEQAIPETEGDTAMEGTVEKAEGEEDNKKPEKEWDDIEDEIPYVKVLNRLLPDDIRVIAWCPAPPPGFSARFSCEERQYRYFFTQPAFTPTAVTATDGAPPDGLREGYLDIEAMNEAARRFVGDHDFRNFCKVDGSKQITSFERRMYEAGVEEVQDVGSVLPYLGRDAADGNDKLPRVYSFNIRGTAFLWHQIRHMVTILFLVGQRLEGPDVITRLLDVEKTPRKPNYDLAHETPLVLWNCVFPGDDDSRIPTAPENALRWVYGEADVVESLWAHYREKKMDEVLANRLLDLISGQVQSTEPKPKGKRVFQGGHEGKLSGGYVPLAKKQLTPTPEEINNRWAQRKGFKNAEEMRESKNWRKAIKDAKQAGTTAAAAAAAAAGAVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2J6</accession>
    <name>A0A1B7Y2J6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_10352</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154750.1">
        <property type="nucleotide sequence ID" value="XM_018305326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2J6"/>
    <dbReference type="GeneID" id="28869433"/>
    <dbReference type="KEGG" id="chig:CH63R_10352"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10352"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601276" evidence="17">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="459"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="505" mass="56539" checksum="F9477D97C69C3B36" modified="2016-11-02" version="1">MRQSMLIGLMVAFFRASQASLLDYAGKLPECGLNCTLEQIPLSACKVVSNDTCICSDEKLRASVQACLLERCKRLEAIDVARIEAEACKRPVRNRKVDIIAPIVIQALGALAVPLRLYARWTTMHRFESDDLIMIFCGLLFIVFVTLGQLEPQAGSVAFGEDIWMVEPEELTFGLKIFFIDESFYLACLGLTKISVLFFYLRIFPNKSFRRATYAAMTYIGLSTTIMLFMQIFQCIPFSFNWDGWKGDFGPHHCLNINVLAFVAGGLSISHDIIILFLPVPLLWHLNMGLRSKIGIFIMFSLGIFILITSCVRLQYIALFTRSLNPTWDFTDPLIWSGIEVSVSMIVVCLPATRVLWKRSLPRCFSSIATLEFSPPKRESSTSSRVAQYSKSNAGGGGGDHRSNEQSSSFDRKAAAAAAARRIAERRKQFFSFRSTNVEPSESELELGDKVRGEVRTQIRYGDAEPPPSSTSRRRGSIESGIHVRTTTTFEDLTGEARGKPFFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2K9</accession>
    <name>A0A1B7Y2K9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154770.1">
        <property type="nucleotide sequence ID" value="XM_018305346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2K9"/>
    <dbReference type="GeneID" id="28869453"/>
    <dbReference type="KEGG" id="chig:CH63R_10372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10372"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="828" mass="92115" checksum="3771C73019870991" modified="2016-11-02" version="1">MPRRPSSMESVGSLGSPIDPKYRKKVAVVGSGSAGIAALWALNRSYHDVYMYEASSRLGGHTNTVTWKNGKYETSVDTGFIVLNTATYPNFINFLKRVKVDTVPTEMTFGVTRDHGLFEWAGTSLDAVFAQRKNIFSPRMWRMIFDIIRFNQFALDLLMADDEDDAAAMNGDSKGTKKEETIGEYLEREGYSDAFRDDYLIPMTAAVWSTSPDKCTLDFPAVTLVRFMWNHHLLSTVSARPQWLTLKKCAKSYIDAVMSGFPSNHLFLKTQVTQVTSEEDGRVRVHTHNGKSDVYDHVILATHGDQALKIIEGSATREEKEILSAFKTSENSVVLHSDLSLMPASEKAWSSWNYLTLSSPSTGKQNIDQVSLTYNMNILQHIPRGTFGDVLVTMNPLHQPNPDTIQGSFTYRHPLYTPAAVRAQKLLPRIQNKRGISYAGAWTKYGFHEDGFSSGLHAAQDHLYAKLPFQFVDSTYSRGRKPSLGLADLLLRLAILIFQVFVIRVLERVVGIAKRAIYPQARRLKNVKATPSSSTNPSLPPSLPHQLPPPPPTIMNALPRLPWRASSQSTQKWSCFFCQHAVRPAPRSGLRSPPAAAARRAASTTPPKQTGPSFGGAPSMEQVHAHYKRKNASTAWYGFPFAPLPLGLRASSWADETNFKICQTTGWGGQPIRAHGPDVDYSEDGLASRLVPVTSANRIRVTFSSSVSDVLPWKFTPQQREVRVLPGETALAFYTATNNSDSDIIGVATYSVTPGQVAPYFSKIQCFCFEEQRLNAGETVDMPVFFYLDPDIVNDVNMRGIETVTLNYTFFKAKYDDNGKFKAPSPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3Z7</accession>
    <name>A0A1B7Y3Z7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155275.1">
        <property type="nucleotide sequence ID" value="XM_018305851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3Z7"/>
    <dbReference type="GeneID" id="28869958"/>
    <dbReference type="KEGG" id="chig:CH63R_10877"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10877"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="335" mass="38462" checksum="42454E248D76D0BB" modified="2016-11-02" version="1">MAQPQTIFPQTHVGFDSITSQIEKKLLKRGFQFNVICVGQTGLGKSTLINTIFASHLIDSKGRMLPDEAVRSTTEIQAVSHMIEENGVRLRLNIVDTPGYGDLVNNDRCWDPIVKYIKDQHSAYLRKELTAQRERYIQDTRIHCCLFFIQPSGHSLKPIDIVVLKKLSDVVNVVPVIAKSDTLTLEERLEFKERIKEEFAFHNLKMYPYDNDEFDDEERNLNTQIKDLVPFAVVGSEKSIIVNGKQVRGRQNRWGVINVEDENHCEFIYLRNFLLRTHLQDLIETTSQIHYETFRAKQLLALKESSAHGGGSRPISPAADRELSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4I7</accession>
    <name>A0A1B7Y4I7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155448.1">
        <property type="nucleotide sequence ID" value="XM_018303425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4I7"/>
    <dbReference type="GeneID" id="28867532"/>
    <dbReference type="KEGG" id="chig:CH63R_08451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08451"/>
    <dbReference type="OrthoDB" id="4789000at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601325" description="Small secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12328" checksum="9771165737B06E39" modified="2016-11-02" version="1">MKFLTLTLFPFGLAAALSTEDKSTLAPTLESRQSTQKCCFTFNADGYNREVISNGFFRIEYQWGGVTSRGLFSGCNVKIDRKGAAPPGGCSEWTFSAEGGNCKSFTTTRVGPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y526</accession>
    <name>A0A1B7Y526_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_08609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155606.1">
        <property type="nucleotide sequence ID" value="XM_018303583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y526"/>
    <dbReference type="GeneID" id="28867690"/>
    <dbReference type="KEGG" id="chig:CH63R_08609"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08609"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="318" mass="33340" checksum="A4981B34B5619BE1" modified="2016-11-02" version="1">MAAAKSPQTELPTFSPVDYAKFFGAGALAATLTHGAATPIDVVKTRIQVDDAMKGLNMLKAGRTIVAKEGASALLTGFGPTAVGYLVQGGGKFAGYEFFKKKFITLAGGPEKAVDRRTAIYLGASATAEVFADVLLCPLEATRIRLVSQRNYASGLVPGFARLAREEGFRGFYSGFVPLLFKQVPYAVGQFSVHEAAVEVIYRAMGPEKKAKMTQLQSTGVELASGVVAGVAAAVLSHPADTLLSAINKGAGDPNQGATSRMIQLAKEFGPKRLLLTGLGPRIVMTCGLVAGQFVIYAQCKTLVGAPAGIEIHKEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y531</accession>
    <name>A0A1B7Y531_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155594.1">
        <property type="nucleotide sequence ID" value="XM_018303571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y531"/>
    <dbReference type="GeneID" id="28867678"/>
    <dbReference type="KEGG" id="chig:CH63R_08597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08597"/>
    <dbReference type="OrthoDB" id="5187219at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601339" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="171" mass="17396" checksum="A8697F83FDAE226F" modified="2016-11-02" version="1">MFASIILTSLVAAGSARAAIAQGSWGIRADFSRCDSGTPLEVVLDGANGPSSPDYTPAPGIVDFKISSPFDGTLVIKVAGAVGLGSPYPPQQVGVHVFAEPTAGDPGVWANATVTPGLGHPAPISQISWNTRSDFTVAPVDGEVVSLETIFDGGSLEVFYCGVPDGVRPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y592</accession>
    <name>A0A1B7Y592_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155681.1">
        <property type="nucleotide sequence ID" value="XM_018303658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y592"/>
    <dbReference type="GeneID" id="28867765"/>
    <dbReference type="KEGG" id="chig:CH63R_08684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08684"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="129" mass="14597" checksum="17979ED4AF9BFE95" modified="2016-11-02" version="1">MRHEVSLWTDSTETRRSTSGTHVALSPATINHQDWRPLKTCQAVGPQSVETSGGMTHRLRPRRSVGIAVMRRSTVNRKPIQPYQLKSNAPPKVDLNWYLTAEVAPMRCTTNGKVWRESQSRASSPFRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5E8</accession>
    <name>A0A1B7Y5E8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155768.1">
        <property type="nucleotide sequence ID" value="XM_018303745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5E8"/>
    <dbReference type="GeneID" id="28867852"/>
    <dbReference type="KEGG" id="chig:CH63R_08771"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08771"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601346" evidence="1">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="37351" checksum="F4630F059F6FA593" modified="2016-11-02" version="1">MVSLRSLLAAGLAATSAFANPIQSLDFTGTSLAPRADPNLTGYLGAFFLGAEPYVYLYLSNGNNPNSFRALNGGSPVIRPTKGTGGVRDPAIVEGGGAEKGKKWYIVGTDLDIGKTTWDAAQRQGSKGIFVWESTDLVNWSAERLVVVENANAGMVWAPEAIWDPTKGQYLVHWASKFYPASDPNHTGAPGPIVIRYAYTSDFRTFSAPQTYIDKSPTNIIDLNILPTSTDGRSFVRFLKDESLKTVFVEVTTTGLFGTWTRPGGSSAIIASGVEGPAAYWDNQVAGKAHVLLDFYGADGYRPYETTNVASNSGWTASSRTGFPTGLRHGSVLPINKTAYDALATRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6D0</accession>
    <name>A0A1B7Y6D0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_09084</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156081.1">
        <property type="nucleotide sequence ID" value="XM_018304058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6D0"/>
    <dbReference type="GeneID" id="28868165"/>
    <dbReference type="KEGG" id="chig:CH63R_09084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09084"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="454"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="788" mass="88906" checksum="7867660CE6507C56" modified="2016-11-02" version="1">MMPGSPSFPDPFAVITVNGDQTKTTTAQKRTLNPYWNESFDLNVNEDTILAVQVFDQKKFKKKDQGFLGVINVRIGDVIELAPDADDQMLTRDLKKSTDNLVVHGKLIINLSTNLTTPARAGQASSSRPSLAPPAQGSSISTLSAPTADARPGSAMGAPNGGPTPGSQVNLPHRPASMTSNGPPPSANGAAAPARQSSTLSPFEDAQGRLPAGWERREDNLGRTYYVDHNTRTTSWNRPTVAGAVEQRNDREAATQVERQRHQNRTLPEDRTGANSPTLQAQQAAAAQNAQNSTMMHTGATSPGTGELPPGWEQRWTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGGQNNQNGTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPAMRILSGQCHIKVRRSHIFEDSFAEITRQSATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMILGKSVVLADMEGVDADFHRSLQWMLDNDISGGILEQTFSTEDERFGVMTVEDLIPGGRDIDVTNENKKEYVDLMVKWRIEKRIAEQFQAFKDGFHELIPQDLVNVFDERELELLIGGIAEIDVDDWKKHTDYRGYTESDEVIQFFWQTIRSWDGEQKSRLLQFATGTSRIPVNGFKDLQGSDGPRRFTIEKAGEINNLPKAHTCFNRLDLPPYKSLEMLQQKLTIAVEETMGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6F8</accession>
    <name>A0A1B7Y6F8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156148.1">
        <property type="nucleotide sequence ID" value="XM_018304125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6F8"/>
    <dbReference type="GeneID" id="28868232"/>
    <dbReference type="KEGG" id="chig:CH63R_09151"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09151"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="92" mass="10354" checksum="12FED92D8C102E40" modified="2016-11-02" version="1">MLSTSKPQSQRKLDETASSRCCADTGELLCYRLPPLFARQSLFRLRFCQQLMNRAISEAIENKASFRHIEEPSGGIKDLTAPFKEYPAGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6U5</accession>
    <name>A0A1B7Y6U5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156213.1">
        <property type="nucleotide sequence ID" value="XM_018304190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6U5"/>
    <dbReference type="GeneID" id="28868297"/>
    <dbReference type="KEGG" id="chig:CH63R_09216"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09216"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="442" mass="48872" checksum="7F6D73B7C62B7450" modified="2016-11-02" version="1">MTWLALRPAAFARAPPFGLTCRPGLRPYSAAAAAAGVSDPLRILFCGSDDFSCAALDALDAERRRNPGLIESLDVVVRPGKLSGRGMKKIREVPLKSLAEKLELPIHERDTFTGWQPPKGINLIVAVSFGLFVPPRLLNQAKYGGLNLHPSFLPDFRGPAPLQHTLLQRRTHTGVTLQTLHPKSFDHGAVVSYTPPIPIPENCTTRDLHDLVTPLAAETLVDSLRRGLHVPPVNDIGWRPTPEELAQQPLTHAPKVTSHDRQMDWRSWSADEVLLRRRVLGPVWCAAFHHDSQTVKRVQFGDAEVVERPHLMKQYQQRCVLRRENKLASDDFPDEVRDVRMVSWVWMPRGKTEEPESWELSFTPYFLDEDGKSILIATPGGEGCLKLSTVTVEGGRPRAAAAVVGDFSEVVKDEDDGHGPGQKGSDWLSWVGTAIVALILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7B3</accession>
    <name>A0A1B7Y7B3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156437.1">
        <property type="nucleotide sequence ID" value="XM_018304414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28868521"/>
    <dbReference type="KEGG" id="chig:CH63R_09440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09440"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1532"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1675"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1993"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2644"/>
            <end position="2664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2685" mass="291864" checksum="B2DA8D91E7590B18" modified="2016-11-02" version="1">MTEVVANGSSSGSGSGYATLDFSATRSALTSASTAIRIAHLRTLEDRISNTDSDPDPAWARRFVQLLFWTHAFYTDRPSRLAVQKCLSALLANGLEPEVLSAFVAAVRAESQKSGIAASNAFVLVEWCSLLMQHLAKTPEWNRLAPQVLLSDADALDKCLLPAAKGGMAHSAIVVTRRGLRKLFAAHPSPEKALKDAVQLLTTKAAQPSAKNAPLLGIIAGVSSRTPAVKAALESQKPQYFAFYTREIIGSRTALPKHVASGLRDFFHDFVSLDELAKEVIPPLEKGLLRAPEIVLSDVLIPLVRSLPEEYDLSQFLAGNLLKPILSNVKSSNVVTRTGAVKAFGVLAAQSRDQQALEKVSEEIVAPIKGGKLASADHRILHCEMLEAIPLSKTTADKIATALAAVSAKEGNEAALTVETSALARSAGYLLQNDAEVAKSVVDACVKGISDKKFPTRRVWLLRVGEIFNSAAGLGDLSSATVKFAEAILPKLLDTYNEVVANPLTAAQNNLTVGAFIVTTLTSLSQQSDVSSTVKSALARVSVPVQCLALEPKPSFLLNPRIYGKIIVEDELIWFCRALSAAAEHLTENTPKPVTVAWAEAFIYVIGASVVTPKVRQIATDSLSRVYATRPALVSQAVVDGIWHWLETLETGDKDSAAVLSKTDKTNLYLVLRAICINPKGLSEQEQSAVRDVVDKQLCSLLVLARHELVPRTSWIELCLRVERDPGDLARQIEGDLLQEISDRTSIDQQSDLVKQAACNAAAELAFVAPDSMTSKIVDFIRKDLEPEELRTIGPVEAAIFRTPEGTAFVDVLAKKAQTTVPDKNNKDYDILKWEAELRTQLAQKKGQQKKLTAEETAKVNAQLKKEAGIREQVRRIEARLLRGIGIVQSLATGPPTEASLWMGPAVKALLDVIDAGASLLTGDAAPLAYLACSDRITSRLGPMRPFVGAATLRARGVTTLSEDYKQEPVDELVTRVLYRLRFAGEQRPFDTVSLIYVLPLVFTVLESGGFGSSPDDRDAQLVLAIEFLSFHTNTCEDLATPRLEVMSSLILSMQQYTQHYKIIKDCFADMCRCVAPNMTPEEIASLAKGAIVPQVSVRTAVLQAISSEVDMSDFDFSDEIWLACHDDVEENVELGRDIWEESGFALSEEVPAKMLPYLDSVDGQLRRAAARSLAEACTAHKLTLEPTLESLKNSYTELAKPRVPQLDEYGMPKKTNLADPWESRHGIGSAFRELTPHMAKQQLDPFFEFLIEKGPLGDQNANVRSEMLDAAIRAIDLHGKGMVEKLMKVFERTLEGPDKNTESSDRVNEAVIIMYGALARHLNPGDSKLPVVIDRLLVTLSTPSETVQYAIAECLPPLVQAYGDKSSKYFSQVLETLLTSKKYAEQRGAAYGLAGLVQGRGISSLKDQRIMMTLRGAIENKKEANQREAAFLAYELLSTILGRLFEPYVIQIVPQLLTGFGDSNANVRDSCLAAAKACFGKLSSYGVKKILPTLLNGLDDDQWRSKKGACDLLGAMAYLDPNQLAQSLPDIIPPLTGVLNDSHKEVRSAANKSLKRFGEVINNPEIKGLVDILLKALSDPTKYTDEALDSLIKVQFVHYLDAPSLALVTRILQRGLGDRSNTKRKAAQVIGSLAHLTERKDLVSHLPILVAGLKLAIVDPVPTTRATASRALGSLVEKLGEDALPDLIPGLMQTLKADNGAGDRLGSAQALSEVLAGLGTTRLEETLPTILQNVESTKPAVREGFMSLFIFLPVCFGNSFANYLGRIIPPILSGLADDVESIRETALRAGRLLVKNFAVRAVDLLLPELERGLADDNYRIRLSSVELVGDLLFNLTGISGKTEDGDEDEESAREAGASLREVLGEEKRNKILSALYVCRCDTANAVRSAAVAVWKALVPSPRILKELVPTLTQLIIRRLGSSNMEHKVIASNALGELIRKAGDGVLSTLLPTLEEGLQTSTDTDAKQGICLALKELIASASEEALEDHEKTLISVVRTALTDSDVDVREAAAEAFDSLQNILGKKAVDQVLPYLLNLLRSDENADNALSALLTLLTETTRSNIILPNLIPTLITPPISAFNAKALASLSRVAGAAMNRRLPNIINSLMDNIINCEDDALTEDLEKSFDTVILSIDEYDGLNTVMNVLLQLTKHDDHRRRAATTRHLCKFFAAGDVDYSRYNQDIVRSLLISFDDRDQDVVKGAWAALTEFTKKLKKEEMEGLVVSTRQTLQQVGVAGANLPGFELPKGINAILPIFLQGLMNGTPDQRTQAALAISDIVDRTSEASLKPFVTQITGPLIRVVSERSTDVKSAILLTLNNLLEKMPAALKPFLPQLQRTFAKSLADTSSEILRARAAKALGTLIKYTPRIDPLIAELVTGSKTSDPGVKTAMLTALYEVISKAGANMGEASRTAVLGLIDMDTDERDDAMTITNAKLLGALIKNVPEEVANGLLKNRVVTSHWSHSSALALNAVLVESPQSLLESPLVDDLPDILSQGMSNKNPYIADNVILATGKYLLSESTKTFETNKKMFEALANVIQPGNSTDSRRLALVIVRTMSRINMDMVRPHVAALAGPVFASVRDPVIPVKLAAEAAFVALFNVVDDETRVFDKYVEGANLPPNTKRSMQDYFKRVTMRLGAQARERREAEGGQGGLGLSNDEVEDEREIWSVGKVDVGEDVFGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7X0</accession>
    <name>A0A1B7Y7X0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156654.1">
        <property type="nucleotide sequence ID" value="XM_018304631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7X0"/>
    <dbReference type="GeneID" id="28868738"/>
    <dbReference type="KEGG" id="chig:CH63R_09657"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09657"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="80" mass="8852" checksum="A8AC91EEE1FC61EE" modified="2016-11-02" version="1">MAFSQWFFEDEKLQITVETKACPVQDNTSDCGRLAQLSDAVLPDLVGDPLEQSVALQKKIWDCSAKLLALLSHLDPSQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8M8</accession>
    <name>A0A1B7Y8M8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Interferon-induced 6-16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156803.1">
        <property type="nucleotide sequence ID" value="XM_018302025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8M8"/>
    <dbReference type="GeneID" id="28866132"/>
    <dbReference type="KEGG" id="chig:CH63R_07050"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07050"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="20101" checksum="B83E3F77024E9261" modified="2016-11-02" version="1">MSGDNKPSSEPEKLVETLPLLPDLLPGNEKRRASGGDGNGNAGNGYGWAYKKAKSWASENPGQAAGLAVGVAVIGAPALVSAPLLGMAGFGAQGIAAGSAAAAAQAGIGNVAAGGLFATLQSAGMGGYGAAVVNGVVQAGGGVSAVQSGYGAFKQWASSKEKSTDGSASGHASADEQTPHKSRFTETDNSKDGGKQNIKGAKTAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9Q2</accession>
    <name>A0A1B7Y9Q2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157300.1">
        <property type="nucleotide sequence ID" value="XM_018302522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9Q2"/>
    <dbReference type="GeneID" id="28866629"/>
    <dbReference type="KEGG" id="chig:CH63R_07547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07547"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="18695" checksum="37F2F871356627AD" modified="2016-11-02" version="1">MVGDRNAPRRGREKTTTSRISNVEIDGSSIALPVVGCGQSIVLPLVYLLRWKKASERLEDLHVIKHERSHTAIPVLRCNAKPHTAPAYGSPWQEYLKSVLFLSAMSAKGVWALDLLVVDLGTLRGALLGGEVHLVGGGPALPHVASNEQEAYEEEEGVEEDIGTGVGRESPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAC1</accession>
    <name>A0A1B7YAC1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157462.1">
        <property type="nucleotide sequence ID" value="XM_018302684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAC1"/>
    <dbReference type="GeneID" id="28866791"/>
    <dbReference type="KEGG" id="chig:CH63R_07709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07709"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05346">
        <property type="entry name" value="SDR_c5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="310" mass="33876" checksum="A771D0FB1DFF79D3" modified="2016-11-02" version="1">MPRCIQITRTFCSSILFRQQLPRLFPLFQYTFNHRTIMSAAAKRLEGKTVLITGASSGIGKSTAFEYARTAPNNLKLVLTARRIDSLEQIAADIQKEVGDGVKIHPVKLDVSKPEEVRQLVPNLPEEFRDIHILVNNAGLVKGVAKAPEIAEEDINVMFATNVTGLINVTQAILPIFKARPDGGSGDIINIGSIAGREPYPGGSIYCATKAAVRSFTDSLRKELISTRIRVIGIDPGQVETEFSVVRFYGDKSKADAVYAGCEPLTPEDIAEVIVFTSTRRENVVVADTLIFPSHQLSMKGAAGLLHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAH2</accession>
    <name>A0A1B7YAH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157473.1">
        <property type="nucleotide sequence ID" value="XM_018302695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAH2"/>
    <dbReference type="GeneID" id="28866802"/>
    <dbReference type="KEGG" id="chig:CH63R_07720"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07720"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="318" mass="36554" checksum="41611F00DADC6C13" modified="2016-11-02" version="1">MEREEPALDAMHQVDTTFPQGANVDLEADENIDDAEMQSLAGSDVDSALGESEAWPSSTASLRSSIVRAREENGRIYHGYKDGKYVLPTDQEELDRQGEEHPESEVVGVDLSPVQPGFTPPNVHYEIDDLEEEWSFSRKFDYVHSMMMTGAFRDWHNFHQQAFESVIFDPNLNTGGWLEIQDIDFPMRCDDGTIPPDCDLGRWNELMMEAGRRSGFLLDTCGKAAEMMTSVGFVDIVRIQFKWPINQWPRDVKHKTLGVWTEANFSVGLESMTLALFTRFMGWRKEEVWDFSARVIAEWRDVERHGYFDVYVTYGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAP8</accession>
    <name>A0A1B7YAP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_07917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157669.1">
        <property type="nucleotide sequence ID" value="XM_018302891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAP8"/>
    <dbReference type="GeneID" id="28866998"/>
    <dbReference type="KEGG" id="chig:CH63R_07917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07917"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="554" mass="60507" checksum="AF14867A0FE29DE3" modified="2016-11-02" version="1">MTTHSPAGFSVLPTNPSPVSVPGSRSLRIRRRQPGKAQLGAEEQVLDLPLPHGPRPGLPVRRRRQLPAHRGRVLEAVLHRPRQLHGPDGPAGHGDGVSSGDGDVHLLSRRGRDRAGAHSHVRGHTKSPEPGRRQVHRSRGGCVQQDLLGAVLSGEDHNLSPWKTVSECLPSLLEDAGPEEGAHFVASNSTTNYLKKGIVDCDIACPIPHTPDSFFSGDFDWFLCFVTHARLLSRACTSLFAVGVSHYPGDYYLDTIEQLTVELEDWRVSLPDNGFRPGGQTKAHSIVDDQERTLALATHFLYYSFLLTMTRMALRHLPSSEAQPDCARRESAMKTVEHSASSLLELVPIIDLAPYTPIWMMAGIPVMAFFVLFELVIHNPRQQQTAANLALLDVMSAHCNRMDVMSNGALPGDFIGEFAHIARSYVIEVDRRTPTGNTPQAPSNTLQASSFCPQWSLPNVDNYGFAPLQVQPGFSDMSPIPASHPAESMDADEMTMAASHPAGTDVMSLFGVWIPELEPMFYQGVLGQYDGGFTGAQQGLGPTPSLSYEYDNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAR2</accession>
    <name>A0A1B7YAR2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157487.1">
        <property type="nucleotide sequence ID" value="XM_018302709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAR2"/>
    <dbReference type="GeneID" id="28866816"/>
    <dbReference type="KEGG" id="chig:CH63R_07735"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07735"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="102" mass="11465" checksum="DDDFDB62DFC81AF1" modified="2016-11-02" version="1">MRFLRVFHRKPKTVSNTTPDDAAGDARTRDFSTRITTSCAHPLSASSWNRMKQGYQPKGMDDRWEISLAGEEKLVFARSWTRSPIVEIQVAAGDEARIVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAY2</accession>
    <name>A0A1B7YAY2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157753.1">
        <property type="nucleotide sequence ID" value="XM_018302975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAY2"/>
    <dbReference type="GeneID" id="28867082"/>
    <dbReference type="KEGG" id="chig:CH63R_08001"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08001"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="774" mass="83714" checksum="FA8C81F66F4226EE" modified="2016-11-02" version="1">MRLHRATPQEVRKYWDEDYVRALEAQVQSLLLALEKQGAESEPSPAALSLSDRASRSVEPDAGLGEDVAGGDAVDEEDEEEEAEEENFVSGNHTNTTATTAANNVFSLGDGRVATGKGPGAMTATTTTTTTTQERSQAAMEELCVMLWRTNVGDGVTIIDDPKTGSRYSVDPVLQQPAPAPAPAPSQPPPAHHRAAVVTPPEQILAYCRQQGLVHEMADLFLANINREHQFTPYTTTADFLPGYPYQAPDEAFLHSAIIATGTAFSSRPDARVVGDAFAEFAEGLVLTCCRQNPTVRVIQGLSMMSWRSLALGRDHFGWMFISMAAGMCVHLRLHVLALDECTARQLEATEQEVRTFWMFYIIDRTAISILGRNCALPWRRVNVPSFDTTFESSTADLAQVSFAWQCRLWYLQDQYMDQVFSTTFESLPIPQQVRVLVASQDALSTFFRSRDDRLHLSGDSTPKPVLQFHLAYQMTILITMPPFLRIFAAISQTPPAGGSSSGSSSNSNINGNINNGNTNNDTNSIIIITLKTPSSCSSSSAPSPPPPPRPPASRAPTAAPTASTRRRTRAAIVHLMNATSWTPALRHQSTYWLRQCLELLRELQTPWPVRAIKSIKIIRVLAQRWGVVRALPLEFSYQVEPPPAPPAPAAAAAAAMAPEAQDDYGVEAMRRSGAAAAAGGVLGLDQGAVDQVQLEYEWDGYAAGGNAVDAPAMDLGALGVESFAAMGGLDMSALGGERANAVGGAIDFLQAFQGLTDCDNFNWLSTNNSNNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB86</accession>
    <name>A0A1B7YB86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157752.1">
        <property type="nucleotide sequence ID" value="XM_018302974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB86"/>
    <dbReference type="GeneID" id="28867081"/>
    <dbReference type="KEGG" id="chig:CH63R_08000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08000"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="242" mass="27735" checksum="5C3E24201B16AF2F" modified="2016-11-02" version="1">MTAMENGLPQGATAGKPVLFFDIDNCLYSRSHKIHDLMAKLIDQYFVTHLSLPEDEAARLTREYYKSYGLAIEGLVRHHRIDPLDYNAKVDDALPLEGILRPDPELRRLLEDLDRSKVRVRLFTNAYVNHGRRVVRLLGVDDLFEGLTYCDYAQYPFVCKPAPEMFRKAMDEAGVERAEDCFFVDDSYDNCKSAAELGWTAAHLVEDGLPVPESKASQFQIRHLRELRDVYPQFFKSTNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBE8</accession>
    <name>A0A1B7YBE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRP40 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157876.1">
        <property type="nucleotide sequence ID" value="XM_018303098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBE8"/>
    <dbReference type="GeneID" id="28867205"/>
    <dbReference type="KEGG" id="chig:CH63R_08124"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08124"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="450" mass="47370" checksum="A8AC8DA029031832" modified="2016-11-02" version="1">MSASAPPSWLFSNNFTKTNIDNITPTSPQQNKMVKKEKKSEKKVKAAAAPTQQAPPDQLMDLVDSFLSENAFTSAHEAFRKQRAQSGWKPSKKQATRPSLVTVFQTWQTSIDGNAAAAKVNDKNVKAVSSNTEKDVDMADAAADSDSSSSSSSSSSSSSDSDSSSDSESEDEKPAPKKTLKRKAPESDSSSSDSSSDSSSSDDSSSEDEAPKAKKQKVKKDDSSSSSGSSSDSSSSSESESSASESESESSDSSSDSSDSSSDSDSDSDSDSSDSDSDSDGSEAAKVPLPDSDSGSSSSDSSSDSDSDSDEDTKKSGKKAAKAADSASNSSATLEKTSPELKPETSTAADPPLPPDPMLNRANNRGGKGANGKDKKVPNKPFSRIPDEVYVDPKFASNEYVPNDYSQRAHEDLIVTKGKGFTKEKNKKKRGSYRGGLIDISEKKGVKFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBL0</accession>
    <name>A0A1B7YBL0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WW-domain ligand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157934.1">
        <property type="nucleotide sequence ID" value="XM_018303156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBL0"/>
    <dbReference type="GeneID" id="28867263"/>
    <dbReference type="KEGG" id="chig:CH63R_08182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08182"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="34666" checksum="9BE74EB6B43DAB4C" modified="2016-11-02" version="1">MAEVTTATRNFVQQQQQQYHKQPLMQRTNNGLFACGHGPVAGSLIESGWGKAPQEEVGGMLDTFSTSAPPSSSLLGPKMATLAAVVAQGHCSQPWPNAELIRPDLGSWAAAILTSKAHVAGTSIHTCESLLRRSSQTLTRTQGTEAKLPTELDNLCKIPKTLAAITIQRCPQNVGRDATQRCATTVESYSIYLDLTLTLPALSASFPPSASVALFFARLDLYQTAAAALTTTTTTTTTTTTRRRRRRLRRCPERDALFPQSTSPVPVSIARDPPHHKHPDLRSFSASPAATDHAHSYATLNSLRRTRKLCAAAARRPKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCF3</accession>
    <name>A0A1B7YCF3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable pectate lyase F</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_05495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158320.1">
        <property type="nucleotide sequence ID" value="XM_018300470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCF3"/>
    <dbReference type="GeneID" id="28864577"/>
    <dbReference type="KEGG" id="chig:CH63R_05495"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05495"/>
    <dbReference type="OrthoDB" id="4846053at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601540" description="Probable pectate lyase F" evidence="13">
        <location>
            <begin position="17"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR09803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="516" mass="50498" checksum="A8CF64C5D632E459" modified="2016-11-02" version="1">MASRLVLYSLAALAAANPIYHPGSDDRLARRHIGGVGHLARAVLSPQQARNVHVDGPARVEVRYARDDDDDKDDVDDKDDVDDKDDVNDKDDCNDLDDKNDPECANAPGTGAGGGVGANAEKPKDGSTDKSKDKSKDKSKDKSKDKSKDKNKDKNKEKETGSGSGSGSGSGSDKKKEKETGSGSGSGSGSGSGSGSDKKKEKETGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSDYEPGSGSGSGSGGSGGGSSGGGSSGGGNGTVPIGGGGSGSGGSGGSGGGLQKTFPTPAGTENLAEAMAVTGTFDGGMKLYDRVPSTCTGGEGGQKDAAFILADGATLSNVIIGGGAGEGVQCEGSCNLVNVWWDKVCEDGATFRQTGGTSTVKGGGARDASDKLFQHNGGGTLEVSDFYGSNIGQFWRSCGNCKSQVARTAIFNNIYVDGGKTIAHYNGNLGDKVTINGACVLGGATVCKNSKGVTGGGEPGSAENDPTLCVETGVQTSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCK5</accession>
    <name>A0A1B7YCK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_05555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158380.1">
        <property type="nucleotide sequence ID" value="XM_018300530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCK5"/>
    <dbReference type="GeneID" id="28864637"/>
    <dbReference type="KEGG" id="chig:CH63R_05555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05555"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="272"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="538"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR09863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="982" mass="107738" checksum="D9578A03DF5B2AD5" modified="2016-11-02" version="1">MRRNRSPTSPSYRALAHGAGAGAVPDSISLLRSFNVDTNPTRPMRPSPLTASTIRDMPLDLVDRIRSFPLFVSAPDEFLAAIGNHLRPQVHAAQDHILTEGDDARAMYWLVRGVVAVTSRDGEAIYAELKPGAFFGEIGVLMDVPRTATIVARTKCLLVVLKKEDLQAELPKFPDMERAIRHEAQERLNILKKKRQEGGHAIKPPSTLVNGVREPAPGEVSTGEMGTIREGAVVNSKKRKSPSPGAIEDPAAGSALGSGIVNVRRTLRELPLFSTLPPDILHQVGLSAQPKTYSPFTDIVQQGSAGNEIFFIVRGEAEVIHETQDAHEPFKKTARATYLRPRLKAGQYFGEVASLGLSEGRTATVRAITTVECLVIPGDALDTLWSRCPPDIKLQVEETARKRYKTSDEDVEMVDAAIAGQRTSKSDPPTPTTPKPLPHMTFTTPSKPASPSKDDGDNMEPKDPDPFLSVDMENMRNRRRNSLAPPTPQSDNSSPIALNGFRTHHVESTPLRFSIPQSPPDSEAPVKRARTLPRRPYPALVPALPDDMLVAVFRYLDIAELMRARLVSHHWRKLLTTHPRVCLDLDLSQHNRRVTDLAIRTVIGPFAGTRPETIDISNCFHITDDGFRSLWETCGRNVKRWRMRSVWDVSANQILDMAENAKGLEEIDWSNCRKVGDNLLARVVGWVVPEPPPPSKQVVISSSTTKSKPQKAAATQQQAQQAAQHRAANIPKPGTIIGCPALKHLNLSYCKHITDRSMAHLAGHASNRLESLSLTRCTSITDAGFQSWVPYPFRNLSHLCLADCTYLTDNAIVSLVGAAKNLTHLDLSFCCALSDTATEVVALGLPQLRELRLAFCGSAVSDASLQCVALHLNELEGISVRGCVRVTGGGVETLLEGCGRLQWVDVSQCRNLEKWIRSGGVMRWGFDERGGNGMSPGQVPLPLPNPSPTTNHVGLGGRPLSFRRRTRKPVRFIVEKGAFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCN9</accession>
    <name>A0A1B7YCN9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158211.1">
        <property type="nucleotide sequence ID" value="XM_018300361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCN9"/>
    <dbReference type="GeneID" id="28864468"/>
    <dbReference type="KEGG" id="chig:CH63R_05386"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05386"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="63" mass="7394" checksum="D09F3C499B6292AA" modified="2016-11-02" version="1">MPTWLFVRVGQWEEQDNSTPAIWLKLKPKEGNDITYHSKLPSPKASFPQPSGQNIERQEQKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCY7</accession>
    <name>A0A1B7YCY7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158510.1">
        <property type="nucleotide sequence ID" value="XM_018300660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCY7"/>
    <dbReference type="GeneID" id="28864767"/>
    <dbReference type="KEGG" id="chig:CH63R_05685"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05685"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000094">
        <property type="entry name" value="Lysine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="237"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="596" mass="66556" checksum="B377A19F576428CB" modified="2016-11-02" version="1">MTFIQSLRLLRPTVRASQVACRAQFHVGQSSGRSSRLQQDGAWRERDSIANQTDENARISEFQKMRLEALEEVGAKDLYNETHPRLVHRRKPMSVPTFRKVWKDANLDDPSNTEIVTLYGRVQSIRLHGKKLVFVTIANEFETIQGMISYRNLGSAPNMNIDTFKLFTRLIGRGDHISITGKPTRTNSGELTVRAVLLPELLAPTMEQIPHTLTDPETRSRKRHVDMMVNPKVADTLRLRSHITKYIRDYLHERSFLEFQTPILAENAGGAVARSFTTQATEFPSKELSLRIAPELWLKRLVIGGVHKVFEIGPAFRNEGIDGTHNPEFTMCEFYSAYTNLSDLIASTEELLAGLAAHCQHLIETQLTSLEPIDASKFARPFRQLEFIPALEEALGFRLPKLTGKDAYSELIAVLALSKVEVPGGIPSTMPKLLDRLAAIYLEPKSFEAPLFITHHPTCMSPLAKSFVCPKTMQLVSARTELFINGRELANMYEEENDPSVQARKLAEHSFFGTGKDPAPLEDVDAPVTPRDAPLDKSYIQALEAGLPPTGGWGCGVERLVMLFSGVNRISDCLSFGTLKNVVGLTSEAQHHSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDH6</accession>
    <name>A0A1B7YDH6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tetrahydrofolate synthase</fullName>
            <ecNumber evidence="3">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_05632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158457.1">
        <property type="nucleotide sequence ID" value="XM_018300607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDH6"/>
    <dbReference type="GeneID" id="28864714"/>
    <dbReference type="KEGG" id="chig:CH63R_05632"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05632"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR09940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="591" mass="62597" checksum="3F0734CE783B7E8A" modified="2016-11-02" version="1">MRPLLLRHTSVTSLSIKHALLFFRPALSPSRLIATMSSSNSSSSPSSSRTYADALALLNTLIPNLKIHALFGSKPKDPEPQDATTTTTTTTTSTTSTNPKPPPADPNLLAIPEMRAWLLRAGLTPDRLSTLSYIHVAGTKGKGSVAALTTSALLSSPSRSVAGRVGTYTSPHLVTPRERIAIDGRPVDQALFAAAFFELWDALSAAPADDALAIPAGSKPFYFRFLTLLALHLFLREGVRSVVLECGIGGEYDATNAVVLPPASSSSSSSSSSGFSPVTAAVVTQLGVDHVAMLGDTPEAIAWHKAGVMKPGVATFTRCLDAQPAVMAVLRARAREIGAELVEVPDDDVRAWSGVPGAKLPGGDFQKRNQALAALAATRHLQVLEARGVDAGAGPGAKTATVPPPPRLRDMSETIVDGLREATLRGRHEVIERAGVSWHLDGAHNADSLAEVARWMAPVVAERRPDADFVLVFNQQERDASALLLGLLREMEAAGVDVRSRLRSAVFTRNDRAGDAENADVAVQEKCAAAFREAYPTVDALVCRDLIEMKNAIDAVAATTTTEAQNIRVLVTGSMYLVGNVIGLLEPEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDN0</accession>
    <name>A0A1B7YDN0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VerA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_05898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158723.1">
        <property type="nucleotide sequence ID" value="XM_018300873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDN0"/>
    <dbReference type="GeneID" id="28864980"/>
    <dbReference type="KEGG" id="chig:CH63R_05898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05898"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="583" mass="65629" checksum="85313AA389E99BE9" modified="2016-11-02" version="1">MGYMMTTAWMPAAILPLVLKLAAVLITVGVLKVVLKAYTIRRKFKQVKAQGIVGVTLFTLGVCVANLDKQPMLPHSWITGHLPIMFEFRKEYPGDINIGNFHPWIINNYQRYFPDMDHCPPVIYLDLWPVLKAPIVAAYKNTVAAQFTQTKNLDKHQISLDFMNPLTKGKDIATLQGDEWKKWRGWFNPGFSARNVSTMVPELIEEIKVFAENLRQRAGQNGSWGPMFQFRNMTTALTFDIIVRAVLDERLHEQTNPTGGPLRVALADQLRLMGIRQAFSFGYLFPWQNKAVDHNNRIVHNQLAPNVVRSLESGLKPSKKKTVLNLALIHLAEEAGGRPIDPTTDPDMMETILGNLKTFLVAGHETTASALCFMFKVLQDNPDCMARVRAEHDEVLGPDPDQAADVLSGSPQLLNSLRYTHAVIKETMRIYQLASTMRGGEAGFYLSDPETGMQYPTEGFLVWDGGPGMQHDPSLWPHVESFIPDRWLAPAEDPLHPVKDAWRAFARGPRDCIGQEVALVEIKLVAALIMRKFDVEEAWDEWDAVQSTKGRKDIVRGQRLYVAGDGIGHPKDGMPVHVRLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDU8</accession>
    <name>A0A1B7YDU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158709.1">
        <property type="nucleotide sequence ID" value="XM_018300859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDU8"/>
    <dbReference type="GeneID" id="28864966"/>
    <dbReference type="KEGG" id="chig:CH63R_05884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05884"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="122" mass="13540" checksum="3862C23962D44DC5" modified="2016-11-02" version="1">MVKLVITNYSATPTNTSSAATLTSEVYAPEVKLDYAAFSDPEGPAWSLPLCPTQHLLAGVIVDSFHHPGCCNAVVTVFASLVRVAALEDEDRNPCRIRSYITIFYPPDFSRPLSQRRRNKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE75</accession>
    <name>A0A1B7YE75_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158890.1">
        <property type="nucleotide sequence ID" value="XM_018301040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE75"/>
    <dbReference type="GeneID" id="28865147"/>
    <dbReference type="KEGG" id="chig:CH63R_06065"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06065"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="61" mass="6852" checksum="388A2FEF4102F88D" modified="2016-11-02" version="1">MIGPQKRKEQEKNEPWPSNPQAVSGQTGTLQTHFATKMATRSPDQSSLRKKTGKRGNRCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF95</accession>
    <name>A0A1B7YF95_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_06479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159304.1">
        <property type="nucleotide sequence ID" value="XM_018301454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF95"/>
    <dbReference type="GeneID" id="28865561"/>
    <dbReference type="KEGG" id="chig:CH63R_06479"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06479"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="55014" checksum="8A9AF5CBAAD44FF9" modified="2016-11-02" version="1">MPAHSDHSGQEDSHGVVVRVPDSASRVAENEKNGASPTSPEGHRSSEPVEFKEGGYGWVVVGCVFLINAHTWGLNSSYAVFLAYYLNSGAFPDASPIVLAFVGGLSFSVGESHSSPRVSQVFPCHLSHTPGPALLIAPIVTFCIPRIGTQPTLGIGVVVQAAALIGASFTTQIWHLLLSQGIGFGVGMGFTFNSTVGVVPQWFVTRRSFANSIATAGSGLGGLVYSLGTNAMIRNIGLPWAFRILAILSFVVNGACCLMMKDRNKALGSVHVAFHKDIFKRIEFWLFVSWGFFGLFGYVISVFSLADYAHTVGFNASQGSILSAMFNLSQGIGRPVIGLVSDRFGRINVAGLGTLIAGLATFFIWIFAGKHFAGTIVFALFGAFAGVLWPTVGPVGAEVVGIQLLPSALSIFWMILVIPATFAEPIALTIKTSGVDAYLNVQLFTGVMYIAAFISIWFLRVWKIRELETIALSEEDVLRNDDAVSLTTSRRTELKPGIFRSMFQGMLTLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFC5</accession>
    <name>A0A1B7YFC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159266.1">
        <property type="nucleotide sequence ID" value="XM_018301416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFC5"/>
    <dbReference type="GeneID" id="28865523"/>
    <dbReference type="KEGG" id="chig:CH63R_06441"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06441"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="13072" checksum="2568FB4F5607B13A" modified="2016-11-02" version="1">MMLVDYFKGPFVVWHRPIFFISAESPSPRHPQHEAISNLHHRGARRHVDGGVRQVQALLVRAGQLHVPGQDSGQCSLGRGHGQGLRRPRDGRLLRPELQGVLPVQEDVPSLHPLQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG42</accession>
    <name>A0A1B7YG42_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159469.1">
        <property type="nucleotide sequence ID" value="XM_018301619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG42"/>
    <dbReference type="GeneID" id="28865726"/>
    <dbReference type="KEGG" id="chig:CH63R_06644"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06644"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="31"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="495" mass="53635" checksum="43BF2F34B0646FEC" modified="2016-11-02" version="1">MNDAQTVNGRRKPEDMIFEVLKKAVDGSTSAARLGILSLSKRNPIETPNYIAVASRGVVPHVTPDNLKKHVSVGAAYMALEDFIEKKNPSALSIPSPDKRPLHTFTCLPETVATVLAPRRCPAIKTPVGNGAKFMAIFTSTGFRNLTVDEYSDAVETLKPDIAIGPADLFHTSTMPVPKKLVRMAGRTEDWTDAFLTPKRREALKESGVSVFAPVLAVPYPIQWEHLRNLADDVVDSISGLAVYDVDLMPDIVDNHEPLVSLPRLSLHIPATPQEVLRQISLGIDLCTIPFLNAISDAGVALSFTFPPPADIHQSKATLPLGEDMWSPENEASLEPLVRGCPCYACTTHHRAFLHHLLNAKEMLGWTLLQVHNHQVATDFFAGVRAALARDGVDGFEEQARRFATAYEAELPQGTGTRPRARGYHFKPDPNPSRINPPAWENFATDGERAGADVNGAAAAAAAGGAETPLVPDVGSLKLEEKGFAEVTHGEGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGZ2</accession>
    <name>A0A1B7YGZ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_03571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159792.1">
        <property type="nucleotide sequence ID" value="XM_018298546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGZ2"/>
    <dbReference type="GeneID" id="28862653"/>
    <dbReference type="KEGG" id="chig:CH63R_03571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03571"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="304" mass="33293" checksum="145EE034EC88C9B3" modified="2016-11-02" version="1">MGIPANMKTVLITGCTPGGIGHALAKEFHAKVTSWPGLHVIATARRPEVLKDLSDLGLTTLPLDVTNAESIAACKKDITELTGGRLDFLVNNAGLTHTVPATDIDMDEVRQTFETNVFGVMAMVQAFVPLLIPARGLIIMISSLSSISPYVFGSVYTATKGALNSYSRTLRQELRPFGVRVMVSMTGTVKSQIAKLNRELPPNSLYARAKDVYIKRLTFSQNNATVSTEEFAQQLVAEALKGEGWLGGWLGGARNWFWAGGMAGTVWFVRLLFGEWLLDELSYRKFELPKLEAIVKKEGVKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIL3</accession>
    <name>A0A1B7YIL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Endosomal cargo receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_04118</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160339.1">
        <property type="nucleotide sequence ID" value="XM_018299093.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28863200"/>
    <dbReference type="KEGG" id="chig:CH63R_04118"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04118"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601706" evidence="11">
        <location>
            <begin position="21"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="13">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="806"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="978"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1381"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1670"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1670"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1694"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1741" mass="192083" checksum="061E9CD0F262FD66" modified="2016-11-02" version="1">MRVSAIACGLLACFVSQVAATALTYKLHANEKACFYAKTQKENEKIAFYFAVQSGGSFDVDYVVTGPGNKIILDGAKERQGDFVFTAQQLGDYEFCFNNEMSTFAEKFVDFEIAVENEVRAQLPAKQGASPEQHTTLEETIFKLSGQLSTISRGQKYFRTRENRNFSTVRSTEGRIINFSMIQCALIVLMGALQVFIVRFFFQGARKGYPRQAAGGAFVLPSSGGLSFVSFDNNGSLVCDCDPGRSFQDLFDPSHDSKRILRSSEITKNTKPRTEGDRLTRYITTTTTSLEVDRDLSMPSSSRHNKKHAKKPQKQPAEKWYIIKDILQERKRGADIEYLVDWEDNPDTGERYRPTWTLSKDVTSKAIFDWRKKLDTLYREDHTAHPEESGAQNEDASTHTPAVESLDSSQPIQSPRKRKRPQTSQSDDSQLWNSEDNLNPPKRGRLLSEAPSTLSSDSFAHTDAASDVLYNNSTFFVAIPSKVEQDFSEYISVSDSQGSTALGSQPISVLEDEDSQVVITENLSQRTIPDSQDYSTFGTQDSQEFGNQLASSTSNKASAKTDREIPDSQKQSSLSKTTDSQAPLLGLPDHHSPFFVHRTPLQSPSRSSQNRQQDSVSSGYIPLTQNSPGQSWEPIFGDTLATSSKHQHPTGLALESQLQSQPRSQLASHPATQLPSQSQAARNRNPSLTSVSDRSIPSHQIDDLTTEYRPEYSTNQSPGVHCRQGLPAVGTPVFQTQPSLDFLLPSRTSSSSNGAPASNSSPLAGIENERAAEQIIACSDTQNDRSQNTQLAQVVAPLPDISASQIGLSSSSAEDPVIPDTVRRKPSQKQRLNTGPTSSGSSRPDDSDAEISSRQLNQSSATPQRDEDEDEHSDPDSFQTCFERRSPPTLSSPYNSQDGGRRSQPIDPPSTMDTSSGEPLSAIEELMRIQEAALQGTLTEGGLASPTTVLVQHHEDDPSMTDAADQAFSASIHIHSQPPISSDWMGEPVTSSTEMPALSSVPSGPTIEAPVDDALRTASMGDIFPGNLMPPESADQLPTTISPSDISRSIEPDLSLSGLQHDNQPLELLPEDDTTAGGKSTVTSPDVEEPYLSAPPAAVDQNEYLVTVSFPANIRPLYLSTMTAYKREIEQFNLALQSDEGLPDKATVEAVGRLFDQLRNICDMPVTLDGPSIDALSAVDLKKHAMGTNSKFFFVGRFLERLQTSHKKILIVVRDINIVGYLEAVVGTGDMAYSLKGLHELESREEHSLLVVLVYCEQPLVDDLSDFDVVIGFDNGILQTDILSRWAEMSGKKPMLIRLMTTCSIEHLELMMPAELEGLERQNALLIALFQARALVANDEQGEMIDNFASLFANQAIDPDPGFGWEPELIPSNVLDFYSSTQSHNQIPPSAEKLSTRKRKADDGSQQVVKRLRVSRSPEQVSGDIDAAVHSHLNPDPSRVHVQTTQFYLDTLSTKISELEHQLEEKTTLEINLRKHITNLAKRVKSHDKTINIIQERHMAALRERSQFESLRDDAQQNEGKAWEETHVWQDKAKTLEEELKKKSAILEEALINAGTVATETYKEKTAELEKALGKIAELEKKLESRDGELGYARDAYQTANHANSELTRENRELKEQVDLLRKSAVGSLAQVQKVNAGEQVKEMQRQIAETQAISKDREKELARIEKELRALKNGRRETRQQSVPRSPRLGMMSPRTGRAAGGSASRGTSPTPHESTGSTPAAGLQFFNTPANGRWGHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ35</accession>
    <name>A0A1B7YJ35_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160411.1">
        <property type="nucleotide sequence ID" value="XM_018299165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ35"/>
    <dbReference type="GeneID" id="28863272"/>
    <dbReference type="KEGG" id="chig:CH63R_04190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04190"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7932" checksum="91BB8CF6B40C7293" modified="2016-11-02" version="1">MRRSPTRRGKAEVSFQDLSWLHEYEGNAELSKAINSMFRWYWDSVACVAFLSDMVREEMACLPKDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN18</accession>
    <name>A0A1B7YN18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161972.1">
        <property type="nucleotide sequence ID" value="XM_018297156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN18"/>
    <dbReference type="GeneID" id="28861263"/>
    <dbReference type="KEGG" id="chig:CH63R_02181"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02181"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="120" mass="12805" checksum="F41222C805CA13EE" modified="2016-11-02" version="1">MIRDALAKYQITAAGESFIPVGGNHVAGSLDRVRECVPRSYGASAKRKLEIRCAIMDGWLSSNTAVIPSLLSLSLGRSSVPIDGPPVPAVRRGGCHTSCAANGLPVLYTFNIPLDEELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP89</accession>
    <name>A0A1B7YP89_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS10m</fullName>
            <ecNumber evidence="4">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Tryptophan--tRNA ligase, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_02601</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162392.1">
        <property type="nucleotide sequence ID" value="XM_018297576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP89"/>
    <dbReference type="GeneID" id="28861683"/>
    <dbReference type="KEGG" id="chig:CH63R_02601"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02601"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="18">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="834" mass="94092" checksum="E7834CBB3265960E" modified="2016-11-02" version="1">MPELCDERLDELLKEAASRLATKQLSRPKDCSLIAIAAAPVDPTLESKAQPKAQESKSITLRDPRPAEDKTHDNAGPGWFGIPKTDPNDPDLKRDLQILHMRGTAIDPKRHYKKESLKARMPRYAHVGRIVEGPTEFHSARLTRKERKQTLVDELLSAEKASGKFRSKYENIQVKKASGRKAHYKKLIERRRRNHTSNLAERGQDEHLANKSKSIETGATRRGLQANRFVLFFQAIAQRQPWLRSLATSTQQTTSDKPEASGNVLAKNEQDEPRYPRSIQALYLQPLRREAEYGIPSCDLQLRSYSLRNLEFFADFALRAAYYLKLPAFGPVPLPRITERWTVPRSSFIFKKSQENFERVTLRRLVQIRDGNPETVQLWLAFLQKHAYYGIGMKANVWDFDKLGVGKTMDTIDQAAGEVIESKWSHLGQNRDLDTVKKVEEFLDKAEIFQWHRLTTSSVPEQAILAMWRHMRPVARRFTISDGRRAASTEKPKVIFSGIQPTGTPHLGNYAGAIRQWVQLQSEPADLCKLIYSVVDLHAITVPQQAKQLKQWKRETLAALLAAGIDPERSILFYQSSVSAHSELMWILSCTASMGYLSRMTQWKSKLSLSSDATILDEGAKASLKLGLFSYPVLQAADILVHRATHVPVGDDQRQHLEFARECVTNFNHNFGPHLVPPETITSTARRVMSLQQPKQKMSKSAADPRSRILITDTPDEIHKKIMCARTDSSNHISYDPDNRPGVSNLLEILSIFDAQGRKPAQLAESLSKESLKDLKQAVSAAVVQGLDGIRERYFDFLSADEGKYLDAVEAQGAKKARLSAEETMAAVRVATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPC6</accession>
    <name>A0A1B7YPC6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162321.1">
        <property type="nucleotide sequence ID" value="XM_018297505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPC6"/>
    <dbReference type="GeneID" id="28861612"/>
    <dbReference type="KEGG" id="chig:CH63R_02530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02530"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="177"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="54085" checksum="C14EE1A130B6D5B7" modified="2016-11-02" version="1">MADNGPASNPAQLPPPPQPNAGAPGYENGQNGQSNPAHMPPPPLHIPQNTNPIPTAITSPMSGVDKVMSPGSAGGFGRRAAPEPNKRALYVGGLDQRVTEDVLRQIFETTGHVQNVKIIPDKNAKGYNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWAYQSNTSSKEDTSNHFHIFVGDLSNEVNDEILTQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRDRPDAEKALSSMDGEWLGSRAIRCNWANQKGQPSIAQQQAMQAMGLTPTTPFGHHQFPAHGVASYEVVLAQTPSWQTTCYVGNLTPYTTPNDVVPLFQNFGYVVESRFQADRGFAFIKMDSHESAAMAICQMNGYNVNGRPLKCSWGKDKTPNPQGGAAGFDPSQQAYSPQSASGPGYPGTPTAYFPQYGGKSPTAAWAFAQDPSELTRYCTGQYGGQHGNYGGPAAQSPAGYGAQPMGYGGPQSAGGYGRGQQPPNAQWPQGPQGQNFNNGFAGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPV7</accession>
    <name>A0A1B7YPV7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162445.1">
        <property type="nucleotide sequence ID" value="XM_018297629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPV7"/>
    <dbReference type="GeneID" id="28861736"/>
    <dbReference type="KEGG" id="chig:CH63R_02654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02654"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="476" mass="53932" checksum="C0C1DBE5AAC6C1FE" modified="2016-11-02" version="1">MSLPSDFVWGFATASYQIEGAAEKDGRGPSIWDTFSAIPGKIADGSSGAVACDSYNRTAEDIALLKSVGANTYRFSLAWSRIIPVGGRNDPINQAGIDHYVKFVDDLLDAGITPFITLFHWDLPDGLDKRYGGLLNREEFPLDFEHYARVVFKAIPKCKNWITFNEPWCSSILGYSSGFFAPGHTSDRTKSPVGDSAREPWIVGHNLLVAHGRAVKVYRDEFKPTDGGQIGITLNGDATYPWDPEDPEDVEASDRKIEFAISWFADPIYFGKYPDSMRKQLGDRLPEFTPEELALVKGSNDFYGMNHYTANYIKHKSTPPEEDDFLGNLETLFESKNGDNIGPETQSFWLRPNPQGFRNLLVWLSKRYNYPTIYVTENGTSLKGENDMPLEQILEDDFRVKYFDDYVRAMADASEKDGVNVKGYMAWSLMDNFEWAEGYETRFGVTFVDYENDQKRYPKKSAKSLKPLFDSLIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ08</accession>
    <name>A0A1B7YQ08_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162647.1">
        <property type="nucleotide sequence ID" value="XM_018297831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ08"/>
    <dbReference type="GeneID" id="28861938"/>
    <dbReference type="KEGG" id="chig:CH63R_02856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02856"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="216" mass="22531" checksum="E0CED448D7F531C9" modified="2016-11-02" version="1">MTGSADGLPVATETSPLLRTSDSEIVNGTTVEVENGHANGAPATADDANDNRDGNPEMAKKMHILLPAVSIGIYLCAVDQLLTVATYAKIGSELHALNNTSWLATAYYITLTSFQPLYGKLSDIFGRKECLLFAYVVFALGSLGCGLAGSFPQLCVARAVAGIGGGGMNSVVAILLSDIVRASYQIATLGAMVPVAVLLVLAFVSTFFIREKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRB6</accession>
    <name>A0A1B7YRB6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_03218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163009.1">
        <property type="nucleotide sequence ID" value="XM_018298193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRB6"/>
    <dbReference type="GeneID" id="28862300"/>
    <dbReference type="KEGG" id="chig:CH63R_03218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03218"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="492" mass="53187" checksum="E78F895AC8C2E102" modified="2016-11-02" version="1">MGEVKSDQPLSLPETDHTAQDVEKQTETDTTSTEVVGQQQQPVAWDDPRETRNPKNWSTAMKILHSAIPCFLAFEITFATSITVPATTQIMQEFSVSRTLSVLPLSLYTLGIAVGPVFIAPFSEVFGRKPIYAASCTLLLAFLGGSAAATSFPALLVCRFLAGTLGSAGIAVGAGTIADVWELGKGAGASLLYILGPFLGPTLGPLAGAYVLEDRGGDWRWTQYVLLLVGAPIWVGTLFMRETSRAWILRAENGEPKITAGRIGALARAAVLRPTKMLLTEVIVSSLALYTAFAYAMIFSYFASSSYVLQRLYGFNLREVGLSFISVIIGYLLGAGLYGFLDARFRIPAVRASTSTPEQRLYAALVGSVMLPVGLFWYAWEAREGGNWAALVAAGIPFGLGAFSLFLSVITYMVDFYGPKSAASALAANGILRYMLGAIFPLFTIQMYEKLGANWAGSVFAFLSLPLMPIPWLLFRYGGKLRQRSKFVITTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS77</accession>
    <name>A0A1B7YS77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-xylosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_00053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163390.1">
        <property type="nucleotide sequence ID" value="XM_018295028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS77"/>
    <dbReference type="GeneID" id="28859135"/>
    <dbReference type="KEGG" id="chig:CH63R_00053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00053"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601876" evidence="8">
        <location>
            <begin position="18"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="9">
        <location>
            <begin position="337"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="570" mass="62990" checksum="C05C4984DCBAADEB" modified="2016-11-02" version="1">MKLLASAALLLAAGVSAIKNPVLPGWNPDPAILRVDDTYYMAVSSFTYYPGVPIYKSKDLANWELVSHALKTPDVLPLYGISAGEGVWAPSFSYHDGLFYITSMTRWGSDPDSRTWPRIWYVSSPDLITWSDLIWAEPYGIDPDIFHDPVSGKDYLNLMGPNNNYDRLWGITQCEIDLKTGRCVGPYRNIWNGTLPQLPSARPEGPKMFRRGDWYYLVLAEGGTSTGHRATVGRSKSPEGPWESSPTNPLIYNGADQKLTVQSTGHATFTDTVDGEWYASLLARRNVKGASPLGREAFLVKVDWEDDWPTMNGGEPLLLSQSVEGPDQELPKPKWVDEFDGPELGLGWYQTRTQYTENFRLKAAGGLGKRAYANASSGIVFHPNVFTLGDRDTAAAVLHKQTSLNMTFSAKLLSTSAGLGPRQSVGISSYLSEVNHQDIGVRGCWSSAGLCVFVDLLPTSTGPSTRPNSTEYPLNLSKIPADLTLHIRATPLKYSLGYSHGNATSPTWLKEFNSKQMGSNPGYPNFEGSMFALFASGNGEPWPYDAPEVGFQRVEEVYYEENLPDYDNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS86</accession>
    <name>A0A1B7YS86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163432.1">
        <property type="nucleotide sequence ID" value="XM_018295070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS86"/>
    <dbReference type="GeneID" id="28859177"/>
    <dbReference type="KEGG" id="chig:CH63R_00095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00095"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="118" mass="12863" checksum="2A91C9C23F3A9A1F" modified="2016-11-02" version="1">MKIPISHWRMGSSPNHRVSERSAATESSDGLASLLATARLFFSALDAVPRARVPLDSLGDTAAQLIPHRSPTAELTLEPQWKRVSEPGLGLDSLQATPRDLAPKETSLDAKLEMFDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSL9</accession>
    <name>A0A1B7YSL9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163544.1">
        <property type="nucleotide sequence ID" value="XM_018295182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSL9"/>
    <dbReference type="GeneID" id="28859289"/>
    <dbReference type="KEGG" id="chig:CH63R_00207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00207"/>
    <dbReference type="OrthoDB" id="5209398at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="33360" checksum="682374AD1BDB3C4C" modified="2016-11-02" version="1">MERPHRPPPLTIPPPPRSRTRVRRRRGPNPRQARQFKRWLLRAQIANDVVHVVAASILLWIMSWFLYNVSRPLTYRTGPAAVALLIALSTDILLDARSIVHAHDPWPGWALLLRLLLGVSLIAVFWVYIALGAVFAPGFSYWAMPDAYGRVLAYMFLWGIGLWDLLFVVLCRRWLGREVKRYGGRARHVFFSPSAFSSRGWRARTSASSPGGGGAHRLASAGGRAGEAPGGVAVVDVEAARPANGDEGSGGGRVGLPARMGLQRMKNSASRDGYRGSGADNDNDDKGCFVTSACAHAAGVTGCLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSW9</accession>
    <name>A0A1B7YSW9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GDSL-like Lipase/Acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163662.1">
        <property type="nucleotide sequence ID" value="XM_018295300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSW9"/>
    <dbReference type="GeneID" id="28859407"/>
    <dbReference type="KEGG" id="chig:CH63R_00325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00325"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601898" evidence="3">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="308" mass="32750" checksum="CDD237EC772E1AFA" modified="2016-11-02" version="1">MRANLAIVAGFLGLASALPADNSASGSDVEKRQSVPTVYLCGDSTTAKAGGGGGTEGWGTFLQYSFAPSKAKVDNRAIGGRSARSYTREGRFDAVADLVKAGDWVVIEFGHNDGGSLTPTDNGRTDCFGDGAQTCQTTYKLSLPVGRDDIWRAGVAETVLTYPAYLKNAAKKFNEKGAKVIISSATPNNVWETGTFKWGYDRFFYYAWLAVEQLGGPSKGYYFVPHGEYAAQAMKNLGAATVNANYPNDHTHTAPFLADAMHKAFVLGLRCGTSALASLVTNSTASLTSTYLGPCVDSYNSTVHALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT70</accession>
    <name>A0A1B7YT70_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_00420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163757.1">
        <property type="nucleotide sequence ID" value="XM_018295395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT70"/>
    <dbReference type="GeneID" id="28859502"/>
    <dbReference type="KEGG" id="chig:CH63R_00420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00420"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="447" mass="50246" checksum="F1CBD761AACC108F" modified="2016-11-02" version="1">MATESPVPIATGSFSTTIVDEAKRWWGTYLDNIRKNPGPFSDPDVAGTEEAFEQFDKIKVLVMFVIDSPRCEILKNLAMSKFKDIHVIDMDTIDISNLNRQFLFRKSDVGKFKAEVAAQFVMRRVKGVNITAHNCAIQDFDHDFYKQFQFVICGLDSIEARRWINATLVQIAEEGEDPDSLIPMIDGGTEGFKGQARVIVPSITSCIECQLDMHAPRAAVPLCTIASIPRQPEHCIEWAHVIAWEKEKPFPKLDKDDSTHVSWLYQKALARAQEFNIAGVTYALTQGVIKNIIPAIASTNAIIAAACCNEAFKLASSAAPTLGMEENYMMYSGNDGIYTYTFKHEKKDDCPVCGQQSRPLEVDPQSTLRDLLDSFAVRPEAQLKKPSIRADNKTLYMQSPLSLEEQTRPNLEKTILELELEDGQNVLVTDPAFPLLQFNFYLRFKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUY8</accession>
    <name>A0A1B7YUY8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger transcription factor ace1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164289.1">
        <property type="nucleotide sequence ID" value="XM_018295927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUY8"/>
    <dbReference type="GeneID" id="28860034"/>
    <dbReference type="KEGG" id="chig:CH63R_00952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00952"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="793" mass="88201" checksum="69242717B4DAFD2B" modified="2016-11-02" version="1">MSVSVNPRRRTPVTRPESPAASGLSLKTNCLRKGATFHSPTSPTTSSSDDALTAPPSLRRSQTNLDDVVDAHCRRMALIVDDIDKSLSNINLVSPNAKSFRDDSLPVPRGFLNLPVVDPAMAKDKSKETERRILRPRTRRSSRHHESDSGLGTSVAHTAETEPATTASKKASAITRSAANTSSSTMEKLPALSSRAVNRIHEHVLRPLRAKPALKDFEAIVLDVPRRIREKEIICLRDLEKTLIFMAPLLNETGVRANTYRSLMKERTKTAALYLDFCLTSIRCIQATVEYLSDREQTRPNDRPYTNGYFIDLVEQIRQYAGQLAAAKETGSDAADMDVDPYDTRSRLSLDHADVFCRTDEIKLFGGIAENGRPAELVRVRKDGKAISMATGLEVDLDDAKSPIQMKRSLSQQLEDDEEIMRSMARRKKNASPEELAPKKCREPGCPKEFKRPCDLTKHEKTHSRPWKCPVKSCKYHEYGWPTEKEMDRHHNDKHSSAPPMYECLFSPCPYKSKRESNCKQHMEKAHGWHYVRTKTNGKKPSSNAGSVTQSTPQLIHMPTPSTSSAATPPPPLDQFNFNDPILAPMHAIGPVGDLASHIDGMEFPSYISDEEFDQVLGASGPFDGQLDMSMSPPDHNTPSTDVSYGPYSYQEGPDFTVNEDIYGAHAQLPTPDRAVFAEKMNMAFPIYQPVPTCQPQIDTAQIAPHISPIGQGNAMLYTPNSLAEVDEGFEDTFTGANEFCGNDFQLFPATTVTKTYEPLFGEVPSAGLGYSQTSQDPFQSIDWMDYQNFPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVR0</accession>
    <name>A0A1B7YVR0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164646.1">
        <property type="nucleotide sequence ID" value="XM_018296284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVR0"/>
    <dbReference type="GeneID" id="28860391"/>
    <dbReference type="KEGG" id="chig:CH63R_01309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01309"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="6">
        <location>
            <begin position="602"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="818" mass="92368" checksum="9F6BFA6C570834B4" modified="2016-11-02" version="1">MTGKEVESISPYGPARSTIKGEPLSKEDIDKYNDFFKASLYLSLGMIFLKENPLLREPLKKEHMKLRLLGHFGSAPGQIFTWMHFNRLIKKYDLDSIFISGPGHGAPAVLSQSYLEGVYSEVYPEKSEDIDGLQKFFKYFSFPGGIGSHATPETPGSIHEGGELGYSVSHAFGAVYDHPDLIALTMVGDGEAETGPLATAWHSTKFLNPIVDGAVLPVLHLNGYKINNPTILARISHKELENLFLGYGWQPYFVEGDDVDTMHQAMAATLEHCVLEIRRFQKQARDSGKAFRPIWPLIVLRSPKGWTGPRKIDDNYMEGYWRAHQVPIPNAATNPEHLKVLEKWMRSYEPERLFKDGRISDELKALCPTGNRRMSANPVANGGVLRKPLKLPDFRNYAIKVEKSGGTNAASMNNMATYLRDVIALNQTSFRLFGPDETESNKLGAVYEAGKKVWMGEYFEEDSNGGNLAPNGRVMEMLSEHTCEGWLEGYILTGRHGLLNSYEPFIHVIDSMVNQHCKWIEKALEVEWRNKIASLNILLTAVVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNCLLSTMDHCLASSNYVNVIVADKQEHLQYLTMDKAVEHCTKGIGIWPQFSTDQGEEPDLVMASCGDISTYESLAAIDLLLQHFPDLKVRCVNCVDLFKLISHEDHPHGLTNSEWVSLFTDDKPVIFNFHSYPWLVHRLTYKRPGNMNLHVRGYKEKGNIDTPLELAIRNQTDRFSLAMDAIDRMPQLHNRGAAAREALRNQQIAARLEAFETGMDPPFLKNWTWSHNGLWKQTVSKITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWI5</accession>
    <name>A0A1B7YWI5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-ketoacyl synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_01563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164900.1">
        <property type="nucleotide sequence ID" value="XM_018296538.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28860645"/>
    <dbReference type="KEGG" id="chig:CH63R_01563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01563"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="2"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2520"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="977"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1010"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR16383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2606" mass="281689" checksum="BF52AC8F9A41E776" modified="2016-11-02" version="1">MEEPIAIVGLSARLPGDGDTPERFFESLLAGRSARTEVPQDRYNADAFWHPDANRSGATRVRHGHFLKGSISAFDAPFFSITPTEARSIDPQQRGMLESVYKALENAGIPLDTVAGSRTGVYVGCFTADYNDHITKDLDIPNKYSALGTVASMLSNRVSWFFDFRGPSVTVDTACSSSLVAVHEACMSLKLREISMAVVGGCNLILTPEMTLKLDAAGVLGPDGRSYSFDHRANGYGRGEGFGAVVLKRVSDAIRDGDVIRAVIRNSSTNQDGRSPGITQPTRAGQAALIRHVYDRANLDPALTRFAEAHGTGTPVGDPIEAGALADVFAPHRSPDEPLYVGALKSNVGHLEGAAGVAAVIKGVLTLESGVIPGNMGFERRNPEIRDAWNLAFPTAPTAWPQRGLRRTSVNSFGVGGSNAHVVMDDALHFLKRHRLVGNHRTEAVPNIARHLSAPLATNGSRDSGIDLSGSESEDLPRLCVLSANDPDAAYRLRKSYKAYLAAKSSQGVLGEAAQLRLLRDLSYTLGSRRTHHSWRTACLANSPRQLQKALEEGPAPVRAKPKPRLAFIFTGQGAQWAAMGIELLAYRAFQESLFAADRYLNDLGCRPKSSSRIDDPEFCQPICTALQVALVDLLTTWGVFPRAIAGHSSGEVAAAYAAGAISREAAWKVAYHRGRLSAKLARSESRPKTGMAAVGLDKASTEAAIDRVNRLGGDGTLEIACMNSGDGHTVSGDAQKIRRLVEMLGEEKVFARRLNVDVAYHSQYMRAVADEYLQAMGGDLEIGALKSPSEQPRFYSSTTGAPIALSQLRRPDYWVKNLVSPVRFTESVTEMLKGSPMPKVNGHVDDRHVNGHINGDVREEAAMEPITDFLEIGPHSALRGPLSSTVKQVRGSSAVDYHSVLHRQRPAVGTILEAVGALFCHGHSFNLARVNEADEPHGPRPLMLTNLPAYPFDHSKEYWVESTLSSGFRKRSAGRHELLGAPVPGGFNADNAAWHNYIRLTESPWIEDHKVSGDVLYPAAGMLVMAIEASRQVADGTKALRGFRFRDVSFKLALRVPDDASGVESQFYLRRYRESSLSDDGTSSWHEFQLWTLQDDEWREHCHGFVQTEYEAEDRPLLSNTIEDDVVAGDNLLGCATEVSVERLYRNLSDSGLEFGPTFQTLSNVRVGKHLDMTATVDSPGERVKQTMPYQYLQPHLVHPATLDAVVHANLVPVVSGDKDAKSTRVPTYLSDGWISARHDLSHDSYAVSAESKMLGRNEVSAEVTATHRQQGHRIMVHMSGLVFKTISDGPSKDARDDTSAHPALNIAWKPDPLFLDREQASKLFELPMTQEDDPARWMKDSEALCLAYIRRLVRDVAQDTIDKMTRHHQRYFSWFQHVVGQSSNEQPPSSDEIIELEARVVASGAPEGKLIIAVGNALADILAGDRDPLDVIFGDKLAEDVYSNGLGSRRCYAQLSRYLDALAHANPAMSILEIGAGTGGATRPVMATLTRGGGRRYKHYDFTDISPSFFEQAKENFRGELAHMGFRVLNVEKDPVAQGFEAGRYDVVVAANVLHATRAMDETLRNARTLLKPGGRLLLFEITNTEVLLGSFCFGVLPGWWLSEDEDRVWGPLMSPASWHRHLVSAGFSGVDAVFDDFPSSPHQMSSILVSTVPRRPEQVPPAEISTTTTSTFVLASETPAQLKLAETISQSIIGRQGPCDITTVSAVVSRDMAGSTCIVVSECEKPVLRDMTEQVFEGVKRVLTQSKVVLWVTRGGTAAAPDPDSELVTGLARVVRSERPDAKFLTASFEATATDDVIVEKCAQILRTAQDDTSDNSFRVVDGIIHVPRLVPAEYLTEHVGAQTGPLRVVDKPLINDDDDDDDNSCSLALQIGRPGHLDSFRFEDDGIYNTPLGDHDVEFKPMACGLSVDDDLSSALGTSDKSTLGFEASGVVTRAGSSSRFQAGDRVFGLSVSGAVKTRVRSSDGLLAKLPDGVSWAHGAALPVDYTTAYAVLCEFGSLQRGDTVLVHGGAASTLGRALIQIAQLQGAEVYATVVGDDDEDDDQAERDALVVACGIPRDHLLSTRDGPLKPSLQKLTKGRGINVLVNSAGADASLDSAASCVAPFGRIVSIGSDVPLSSASLVRGRNVRLESFGLAVCASHDLARTGALFQRMVDLVFANWSSVGRPVPVSVYPFSRVPDAFRQLQAGGHKSKVVLAPHDHDVVPVLSARKATSVFDPEASYVVAGGLGGLGRSVARWMASRGARNLILLSRRGALEKPAIDLVRELESLGVNVVTPACDVTDEKALRHVMTELAATLPPIKGCIQGSMVLRDNLVENMSVDEWKAATLPKVDGSQNLCSLLADTVDFVVFLSSFVSLFGNPEQANYAAGGAFQDALARQLTARGVNAVSVDLPIVEGVGYVAEKPGLWDHLRSAGWTHISEAELHAVLDYHCRPAAAEDGQGQHTADVTRAQVVPRLWLPRETPSWGGDPLFSHLQLRATGEEGKTDDEAAAAAATGKTTVNHRALLQGTSSREEVEGVVLEALLLKIARMLSVGVANLETTRPLHAYGIDSLTAVELRSWLAKELGAEVSVFDITNNSSIAQLAVVAAKKSSLAPRFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYH6</accession>
    <name>H1UYH6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_05293</name>
        <name evidence="14" type="ORF">CH63R_13946</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02000615">
        <property type="protein sequence ID" value="CCF33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151238.1">
        <property type="nucleotide sequence ID" value="XM_018308920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYH6"/>
    <dbReference type="STRING" id="759273.H1UYH6"/>
    <dbReference type="GeneID" id="28873027"/>
    <dbReference type="KEGG" id="chig:CH63R_13946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13946"/>
    <dbReference type="eggNOG" id="KOG3123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_1_0_1"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="286" mass="31878" checksum="8AEA954E3F81A089" modified="2012-03-21" version="1">MLYLVGLGLSDETDITVKGLEVVKKASRVYLEAYTSILLVDKAVLESYYGRDIVVADREMVESNSDEILRDAQTEDVAFCVVGDPFGATTHTDLVLRARELGIPVRTVPNASIMSGIGATGLQLYNFGQTVSMVFFTETWKPASFYDRIKENRDVGLHTLVLLDIKVKEQSLEDMARGRRVYQPPRYMTVGQCAAQMLEIEEEKQEGVYTADSLAIGAARVGGKTEKFVAGTLKELCDTDEALGGPLHSMVLLGRRAHELERDYIREFAVNKETFDKSWNAEYGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYM5</accession>
    <name>H1UYM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05336</name>
        <name evidence="3" type="ORF">CH63R_12984</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000632">
        <property type="protein sequence ID" value="CCF33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152375.1">
        <property type="nucleotide sequence ID" value="XM_018307958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYM5"/>
    <dbReference type="STRING" id="759273.H1UYM5"/>
    <dbReference type="GeneID" id="28872065"/>
    <dbReference type="KEGG" id="chig:CH63R_12984"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12984"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_5_1_1"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="305" mass="33713" checksum="7645BCEF58A68A37" modified="2012-03-21" version="1">MATETQGTFEVDGHKLHSTTWTPQGPIKAKLIFVHGFSDHVGRYHELFPYLASRGIQVFSWDQRGWGRSAPKPADRGLTGSTSRVIADVAAFIRDKIPSSSSADANAPVFVMGHSMGGGQVLVLASNPQYNDLVAQVRGWLLESPFIAFTPGQEPSFLKVFFGKLASRVLPRQQLVNEIPAENLTRDPVVQQSIRDDDMLHNTGTLEGLAGMLERTDALANGKMRLSPEVKSLWLGHGTEDKTTCFHASKKWLGAQSIDDSTHKPYEGAYHQLHADLCKDEFFKDVGDWILERAGETMARPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZG5</accession>
    <name>H1UZG5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_05571</name>
        <name evidence="18" type="ORF">CH63R_09838</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02000729">
        <property type="protein sequence ID" value="CCF33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR05718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018304812.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UZG5"/>
    <dbReference type="STRING" id="759273.H1UZG5"/>
    <dbReference type="GeneID" id="28868919"/>
    <dbReference type="KEGG" id="chig:CH63R_09838"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09838"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_3_2_1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
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        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
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        <property type="entry name" value="Multicopper oxidase"/>
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        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
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        <property type="entry name" value="Cu-oxidase-like_N"/>
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        <property type="entry name" value="Cu-oxidase_2nd"/>
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        <property type="entry name" value="Cu-oxidase_C"/>
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    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
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    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554709" description="laccase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="74"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="200"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="420"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Pfam" id="PF00394"/>
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        <source>
            <dbReference type="Pfam" id="PF07731"/>
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    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR05718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="572" mass="62565" checksum="5D0336063CD34149" modified="2012-03-21" version="1">MYQSLLVAGALAASVASALPSLGSLPEPKLFPRAACSGNTASTRSEWCDYSVDTDYWTEAPDTGVTREYWLELTDVTVAPDGVSRSAMAVNGSIPGPTLFADWGDTVTVHVTNSLTSSNNGTSIHFHGIRQNYTNQNDGVSSITQCPTAPGDSITYTWKALQYGSTWYHSHFALQAWQGIFGGIVINGPATANYDEDLGMLFLNDWDHQTVDELYSTAETSGPPTLDTGLINGTNVYGDDDSSSQTGYRYNVTWTSGTSYRMRLVNAAVDTHWKFSIDNHTMQVIASDLVPITPYDATVLDIGMGQRYDIIVTADQADTADTFWIRAIPQAACSDNDSTDNIKGIISYTGTMTTPTTTGYSFTDSCDDETDNLVPYVSKTVSDANWDELESATVGKNTAGLFKWYLNSTSMLVDWANPTLEAIVNGTTSWDTEEAVIELSEADQWVYFVIETTLAVPHPIHLHGHDFFVLAQGTGTYSSTSVTLNTANPPRRDTAMLPASGYLVMAWETDNPGAWLMHCHIGWHTSEGFSMQFVERYSEIAAITDNTTLTDTCSTWTTFQEEYSIEQEDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZL5</accession>
    <name>H1UZL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_05614</name>
        <name evidence="6" type="ORF">CH63R_08141</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000748">
        <property type="protein sequence ID" value="CCF33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157893.1">
        <property type="nucleotide sequence ID" value="XM_018303115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZL5"/>
    <dbReference type="STRING" id="759273.H1UZL5"/>
    <dbReference type="GeneID" id="28867222"/>
    <dbReference type="KEGG" id="chig:CH63R_08141"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08141"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003293_0_0_1"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054548">
        <property type="entry name" value="SCP160-like_KH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22952">
        <property type="entry name" value="KH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="380"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="699"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="766"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="861"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR09376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1276" mass="138685" checksum="C216E8D5AF2467D5" modified="2012-03-21" version="1">MASTDSAVSNGAEPSAAQKLLQTHADHHPTVEDVPDEDLPLKSGDSATWAEPISTKAAGKQKETSAPSKKFDPQSHDLFPELGASSKAPTVAPIWGAKSNVSTPANGLSRSSTPASGNATPKNGPPSMSIPGRNVETVVLEPQFILPRGQLKRPIPDIMKDINRKSRANITLSTATNGRLKFDATGPQDVAQQALKDLVQQIGTKTTIKVPIPQSARAHIIGKGGSVIKAIQEKSGARVQLPKAEEGSAPVDEDDDSTIDVLVEGNALSAASARNEILKIAGERTANVNTKLRGIPAEFYPFIAGPGNSHVNQYENNGVQVRVPPHQIWAPRGRNLAANEGERPVFVPATDNHIQLAGDRAAVQAARAEIERRVQELQNQLAIDQFSLQKGRHQFIAGRRGESLDEFFGQTGCTILLPTDDDDDSVTVIGPIAQLSKGVETAMDRAMNMQSTTFDIGRFHKNAPGGVNVHARHVTRYLRHRDLFDDIERAHSTHISTPFNASGSSPYELYSRDGKKALQAQSAIEKLVHAVPPARIAPIPVDPFYHNYLVKDVGPRMRNSHGVHVILPESGEPDAPVLLVFEGPTAPEPKPEIKTGRPSDDEIRTFQEALEVARKQILDIINKQEQIASASIDVPQKFHERLRRFIKKEQANRADDQIPIRVSSVGTVVTLRGPASAVKKLEDKVIAFVEQEKEDEKERGFTMSFDFPQKFANHLIGKGGSNIKELRDRFDVEIQVQDGKVELKGPKAKAEAAKAHISSLSRTLADEVTHILKVDPKFHRELIGAGGSVTNRLQNKYKVLIFFPRSGKSPKDDEVNADAVSDAGKPKRHQEPDEVIVRGPKKGADEARDEILSLLQYLKDTSFTATVSVQQKQVPSIIGQGGAALEELRISSGAKIDIPSGRDADTVEIQIKGTKAQVAAAKKALEEKRDVFNDTIVRTIEVDKKHHKSLIGTGGANLRDLVIKAGGSDDRRELARTIQFPKQEADGHTIKVEGRSDIVNKICARIEEIVAEKESQITEVLDVPTEKHRTLIGRGGDAKRQLEAQFTVSIDIPRQGDGKTGVKITGRPENVEKAKEHIASLVKEQEGETLQVPRSLHHSISNNGQFFRQLRNNHQISVDHAGQSVPPKPSSASRSNGSALPLITDDDDATADVHSWKVVDSAAGEDGDIAWVLRGSPENIEKAKAAIASAIEQARKNTHTGYLVLPDPKTYRYVIGQGGSKVNSIRKQSGCKINVPRNDDKEDAIEVIGTAEGVEKAKGLILDAVKEGLSSRVSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZU8</accession>
    <name>H1UZU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05681</name>
        <name evidence="10" type="ORF">CH63R_06488</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000783">
        <property type="protein sequence ID" value="CCF33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159313.1">
        <property type="nucleotide sequence ID" value="XM_018301463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZU8"/>
    <dbReference type="STRING" id="759273.H1UZU8"/>
    <dbReference type="GeneID" id="28865570"/>
    <dbReference type="KEGG" id="chig:CH63R_06488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06488"/>
    <dbReference type="eggNOG" id="ENOG502RS99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022732_0_0_1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="55"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="57418" checksum="3263000B66F5D50F" modified="2012-03-21" version="1">MASGVIAGLLARSHAPSPSPKMPADVLKEIDDTDVPFFMAGILLPHAVCTLLILARVVSRVWVLRKWFIDDTLIILSWLFSTALCIVYGITATTPSLLGAPPNEAADAVLKDANPYIMRTYLGLIYYQLCLCLTKLSILAFYLRVFVSRQRERYLAWATVAFVLLYGAPMLLMSFLQCHPAPGQFFGQPMMCFGFPDLLISSASLHSATDAWLILMVVPCVMRLDLPRRQKVALGFVMSLGVFVIVASMIRLQLSLHLHYRPNSAAIRNTLGFFVMTVLECDIALICASAPTLRPLLARLFPGLVNSAKKRSLEAADGQSFDLTSLTYHGYPWSTSSTPFTRSRNASVASHLNKTRMPVPPVPALTMAQRTATTLSPGNWIAGTAPRTRDRHCGNDRRPMSDETWAMKRSSSIYSQDSVWEGFGDDDLERQGVILKTMRVSLHSEYIAQPDLDLGRTEPLKINRMSPASGLSGDTWVADRSSSGTKNESIDGALASRLPKEEDNGKPEVPPRSPLRDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V135</accession>
    <name>H1V135_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06029</name>
        <name evidence="3" type="ORF">CH63R_13969</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000952">
        <property type="protein sequence ID" value="CCF33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR02743.1"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="164"/>
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        <source>
            <dbReference type="Pfam" id="PF13649"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="232" mass="25742" checksum="3F6DFCADDAC7F55A" modified="2012-03-21" version="1">MAAAPEDRQVPVPPENVKARLKESYDIIAPAYNDWTAQHSSLRIEYLEKLMEKLLAAKPLSGQMSLVLELGCGCGLPATERLLLAPDVFVTANDLSSTQIALARENLAHHGTDRVAFVEGDMMGLDFADASFDAVVAMYSIIHLPRDEQSDMIRRISKWLKPGGLLLANFASENMPGLVMDKWLHDKGWMYWSGWGADETLSKVKDAGLEVILNDVVQDEVDATFLWILAKK</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1Y7</accession>
    <name>H1V1Y7_COLHI</name>
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        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
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        <name evidence="11" type="ORF">CH063_01105</name>
        <name evidence="12" type="ORF">CH63R_10082</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="CACQ02001068">
        <property type="protein sequence ID" value="CCF34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10082"/>
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    <dbReference type="GO" id="GO:0005759">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="298"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR05962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="459" mass="52702" checksum="2A125ECA0EBA6C10" modified="2012-03-21" version="1">MSWKKTDRLMDTIRHYASFPATGVSLRQMVQFGERPSVGTLFRASQFLAEELPIRLAHRVQELDELPDGLNDMPSVKRVQDWYAQSFEELTQLPRPDLDRATKERLMKPTKSYGKGSMLSEATRNPSIEEGQYASLPQSNGNGWSKQKNIAARRYFAMVDDTGDWPAELRLYNERFAKALHGIKRRHDGVVTTMAQGILEYKRKRQRMQIDNNIQSFLDRFYMSRIGIRMLIGQHIALTDQSHHRDPSYVGIICTKTNVQDLAQEAIENARFVCEDHYGLFEAPKIQLVCNPNINFMYVPGHLSHMLFETLKNSLRAVVETHGQDKQEFPVTKVIVAEGKEDITIKISDEGGGIPRSSIPLVWTYMYTTVDRTPNLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYTLHKRLKDREITERRQVGDAQEMMNRGNDPNPGYYKRDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2P4</accession>
    <name>H1V2P4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_06482</name>
        <name evidence="15" type="ORF">CH63R_08963</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02001165">
        <property type="protein sequence ID" value="CCF34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155960.1">
        <property type="nucleotide sequence ID" value="XM_018303937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2P4"/>
    <dbReference type="STRING" id="759273.H1V2P4"/>
    <dbReference type="GeneID" id="28868044"/>
    <dbReference type="KEGG" id="chig:CH63R_08963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08963"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_3_1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990439">
        <property type="term" value="F:MAP kinase serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR07442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="450" mass="48711" checksum="3DB89B83D69E6F0D" modified="2012-03-21" version="1">MGQTLSEPVVEKSSAKGEDERLLYGVSAMQGWRISMEDAHTTVLDLLPPGSDEAKKHESKLSFFGVFDGHGGDKVALFAGEHIHDIIKKQETFKKGNYEQALKDGFLATDRAILNDPKYEEEVSGCTACVGLISDSKIYVANAGDSRSVLGIKGRAKPLSQDHKPQLEAEKSRITAAGGFVDFGRVNGNLALSRAIGDFEFKKSAELSPEAQIVTAFPDVETHEISDDDEFLVIACDGIWDCQSSQAVVEFVRRGIAAKQELDKICENMMDNCLASNSETGGVGCDNMTMVIIGLLRGKTKEEWYEEIAKRVAAGDGPCAPPEYAEFRGPGVHHNFDDSDSGYDVDVENKGKPFGIGGYKGRIIFLGDGTEVLTDSDDTEMFDNAEEDKDLESQVSKASSASSKDGETDNKSATKAEQESKAGVDKAQEETKPAATSQSTESQKIDSKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4G8</accession>
    <accession>I2G7G8</accession>
    <name>H1V4G8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EC88 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_06971</name>
        <name evidence="4" type="ORF">CH63R_14217</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the invertebrate defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001407">
        <property type="protein sequence ID" value="CCF35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151509.1">
        <property type="nucleotide sequence ID" value="XM_018309191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4G8"/>
    <dbReference type="GeneID" id="28873298"/>
    <dbReference type="KEGG" id="chig:CH63R_14217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14217"/>
    <dbReference type="eggNOG" id="ENOG502T4TA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4848580at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497581" evidence="2">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="95" mass="9944" checksum="A97597A43D8D4CEB" modified="2012-03-21" version="1">MQFTTILIALLPALAAAQLPVSNEVCPAGLRTTCPAGTDGVSRCSILNGQNLCVIDCEAQSTCRTQCKQQGHINGFCTIGDNPCICSDIDPGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5F8</accession>
    <name>H1V5F8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase bli-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07240</name>
        <name evidence="4" type="ORF">CH63R_10559</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001547">
        <property type="protein sequence ID" value="CCF35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154957.1">
        <property type="nucleotide sequence ID" value="XM_018305533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5F8"/>
    <dbReference type="STRING" id="759273.H1V5F8"/>
    <dbReference type="GeneID" id="28869640"/>
    <dbReference type="KEGG" id="chig:CH63R_10559"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10559"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF33">
        <property type="entry name" value="OXIDOREDUCTASE BLI-4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="343" mass="37431" checksum="F2507FB34848D37F" modified="2012-03-21" version="1">MSQNTIAENFGGAASKLGTHQFTLEECPDLTGKVAVVTGGSEGIGYGVTYTLLKNNISKIYILSVLQEVVDGAKDAISKELGAEKAGRTKWFQCDLGDWRRVKEVAEQIKNDTDRLDIVVNNGGRGIMTYQLTDYGVDRHMAVNHMGHVVLTSHLLPLIKKTAEGGDVVRIANQASNAHNAAPSDCRFESLDELNQDLGPNGQYGRSKLAGILYARYFNRKVTQNGHPNVLMNATHPGFVSTKMSKQEIFEPYPLGGYAMAVGMEPFKKSQWEGAVSMVYAATTTKESGQYICPPAVPEPGSKLSQDDALADQLMELTRQIITEKTKSQSVDKGCPMDDLVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7K7</accession>
    <name>H1V7K7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07828</name>
        <name evidence="9" type="ORF">CH63R_04952</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001883">
        <property type="protein sequence ID" value="CCF36209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161173.1">
        <property type="nucleotide sequence ID" value="XM_018299927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7K7"/>
    <dbReference type="STRING" id="759273.H1V7K7"/>
    <dbReference type="GeneID" id="28864034"/>
    <dbReference type="KEGG" id="chig:CH63R_04952"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04952"/>
    <dbReference type="eggNOG" id="KOG2393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025955_0_0_1"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF36209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="716" mass="79317" checksum="F151880E12885818" modified="2012-03-21" version="1">MSAPPTSGLPNGQNPNGQQSAQAGQPGQPRPPPIKRRPRGDPLVARKRPGAPRPAASRPPPGGLQTASGARPSPGASGHHGLQRPETEEDVKARRAANGGWLDPAPQNMREFKIVTTKKALRDGVRHHVMKLSSAKADLEKRGIDPTNQEEFTRPVTLQRRDPRQPPPGREVKQEQAEPQPVDEKEAERLAQLKAEREAVRAVELAKSAPSLKDPNADKKAKPKEKEKDVQFHRQPRSEKEKKQQELRYEEALPWHLEDADGKNVWVGSYVAPLSETTICFVATRDGKFAAVPLEKWYKFTAKPHFNTMRLEEAEALMSKKTDVGRWYMRDKQKKSEQEEWEATRHALYGPARIKTESSTFRAASREEKLDHDQIDMEGDEFQDDDENPGLEQDNDEEYKEANDRIRRDQLGANLFGEADERRVEKELNELKKAEEERRKEGKKTQKALIKREKETIYQSDSSGYDPFESSSSEDDSDEEKQKEENKDKEKDEENKDKDKDADPKDKTASGVSSKGNTTPSGRQKHTDALKKGKSLKRPGSPNLSESSGNESSRKKLKKHAATSVHQSRSSTPSAGLKSNLGKGAMSDGEATGGEMSDGQLRKKKIKLVGTGSRGTPVGSRAGSPMPATSGSKPGSPLPEGSPAPRAGSPNGPIEAWEIVDALPELPGGISIGNLMRRFQGRIGDGPGQMDRKEWIKLVKENCAYGPDKILRRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9H2</accession>
    <name>H1V9H2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH063_08341</name>
        <name evidence="20" type="ORF">CH63R_09303</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
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    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
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    </reference>
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        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
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        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
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        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
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        <text evidence="3 18">Belongs to the ALAD family.</text>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
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        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
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        <property type="entry name" value="DALDHYDRTASE"/>
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        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
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    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
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    <feature type="binding site" evidence="16">
        <location>
            <position position="176"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
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        <location>
            <position position="263"/>
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        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
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            <dbReference type="EMBL" id="CCF36875.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
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    </evidence>
    <evidence type="ECO:0000313" key="22">
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            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="383" mass="41523" checksum="DF7B704916890E91" modified="2012-03-21" version="1">MSFSSLVQDLTLRDSGVPRRPRGAQSVSTIDDGRSQISRAMSYASTAATSVSISGDISSQLHGGYFHPLARSWQAERQLTKSMLIYPLFVSDQDDEEALIPSLPGQYRRGINKTMAYLETLVRKGLRSVMLFGVPVRPGVKDALGTAADDPEGPVIRSIRAIRQRFPQLFICADVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVAIAYAVAGAHCVAPSDMNDGRIRAIKLKLIEEGIAHKTVLMSYSAKFSGCLYGPFRDAAGSAPSFGDRKCYQLPPGGRGLARRAIVRDIGEGADIIMVKPASQYLDIISDAKELGKDMPVAAYQVSGEFAMIHAAAKSGVFDLKQMAFESTEGILRAGATIVISYFTPEFLDWLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9L2</accession>
    <name>H1V9L2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_01596</name>
        <name evidence="5" type="ORF">CH63R_13681</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Will I."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R.J."/>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <sequence length="355" mass="37669" checksum="46F81AC488F23E65" modified="2012-03-21" version="1">MSSIGPQLPPHLTKRKRIPDDEGVESPPIKQSRNTDEIDLEDDSDDDGFGPSAPEAAFSKLESLPNPPVGPALPPTNPTNASEIALDDSESEDGYGPPNPSVAPTAEAPKTKTSTGPTLPPKQAIGPAMPPPNHRLGAEDDGGDNSSSDSDDDYGPALPSSTTSAQRTQAAAAAAAAQASAGPVAPQRDDWMLAPPTQSGYHERDPTKLKNRKFASGKSSAAAAGGGGGISSIWTETPDQKRKRLEDAVLGRGDATAAAGPQQPRRTKEEEERDRRISENIATARGRSMYEDHQQNKKGAAKTSKDEEEEDDPSKRAFDREKDMSLGGKIGTAQRRELLNRAKDFGGRFQKGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAX6</accession>
    <name>H1VAX6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_08735</name>
        <name evidence="6" type="ORF">CH63R_13120</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002439">
        <property type="protein sequence ID" value="CCF37379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152511.1">
        <property type="nucleotide sequence ID" value="XM_018308094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAX6"/>
    <dbReference type="STRING" id="759273.H1VAX6"/>
    <dbReference type="GeneID" id="28872201"/>
    <dbReference type="KEGG" id="chig:CH63R_13120"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13120"/>
    <dbReference type="eggNOG" id="ENOG502S86Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016574_2_1_1"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF37379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="741" mass="82885" checksum="6D2F7727299AB6AA" modified="2012-03-21" version="1">MTQAVKRACDACHRRKVKCDGVNPCRNCHTAQLSCTYNAIPQKKGPKGSRAKVISELRETQRQTSLSARVQNRMNGIPNPPGPAALAPTPGLLSADLVKECLEFYFANLYEKMPILDRRQIDLQLPYMEQNRDTYCLMTSLCAFMMLQPGMSMPPGDPYNLDVMPGATIVASQLLLDETLQVRKGYDYLESMTFNTLATNFFVYGCYHGLELHDKAWFHLREAATMMHLNGMIKEETYHGPQWDNAESSRRRRLYWLFYIMERAHAIQRQRPLTLQASINPPNSADDPSDPLSHQLNSFIMLVNLFRPFDDAFTTVWNKTRSNLYVATLQKQLNEVLPTYLCQDGQLSDLRTNQQWLKSTVWQLTHGNMNSQNEESMNFNYPVDLSRELLMTLASHFPGQGMELMGSGLIEKLFEISCNMTDFLAVQPAARDPFTVGPREQLNQTLNIVAVLRHGDHRFLPLLLSKVAEIMPRLTNPMLQNAPENSNLGNIDIFDGFGNAGMAQPPPQMQMQMDTEYERKFPSADYEKKYNMSDVTSSSSETNTVAASSTGAPSVPPVTAADINSPFASSPAIMSPPMEYPHNGMNDYGCTPMPDMVMSPMGQNGSAMNGSSTINTQHQRQQQSHHLMQNQCMTPQQQMQPGMSQHHPHNIQQGNINSPSIQGQQGLGSGSIPTSHPMGPGGNNLMNSIPRQQPQRTSSSFAIQQQPIPRTVGDFHALQRANSDIPGLSGIATEMDFNTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCF9</accession>
    <name>H1VCF9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01795</name>
        <name evidence="3" type="ORF">CH63R_13145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002702">
        <property type="protein sequence ID" value="CCF37912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152536.1">
        <property type="nucleotide sequence ID" value="XM_018308119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCF9"/>
    <dbReference type="STRING" id="759273.H1VCF9"/>
    <dbReference type="GeneID" id="28872226"/>
    <dbReference type="KEGG" id="chig:CH63R_13145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13145"/>
    <dbReference type="eggNOG" id="ENOG502S28Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016852_0_0_1"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="282" mass="30379" checksum="B83F3E827D077386" modified="2012-03-21" version="1">MASAKTTTYRYGPNVLQTYDVYIPSAFGNEAVAAKKHWLVWIHGGFYRDFAQNSTGINAAIASLEANSSDVLATQVAGIASLNYRLSALPGVQPNNTPPNELQNARWPDHLTDAVAALKDLNEHYPIDGNYVLSGHSVGAQISFFAALETLNDPSVPKPAAVLGISGIYDYPQLHVTHPSYDSLVLNAMRQDQLVEASPAKVDAGRYAALDVEAFILAHSRDDGLVPWDQLEAIEATLGSLPELKSKTYVVELQGAHNDIWRGGVALAKAFTETLALLGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDE4</accession>
    <name>H1VDE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_09382</name>
        <name evidence="6" type="ORF">CH63R_01847</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002881">
        <property type="protein sequence ID" value="CCF38247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161638.1">
        <property type="nucleotide sequence ID" value="XM_018296822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDE4"/>
    <dbReference type="STRING" id="759273.H1VDE4"/>
    <dbReference type="GeneID" id="28860929"/>
    <dbReference type="KEGG" id="chig:CH63R_01847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01847"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064147_0_0_1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF35">
        <property type="entry name" value="ACYL-COA THIOESTERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="206"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF38247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="328" mass="36362" checksum="EB22C8F37F8328BA" modified="2012-03-21" version="1">MSDSAMANTLQEQVAVDDLGSDQFISRVNPARMGNAANIAYGGCAIGIGLQAACSTVPPKYLLYSTTGNYLGPALTDRKLKCSVRRVRDTRTFATRIVEISQDLDDGKSRLCMVMLADFQVKEETSLLVYSAPPSMNYSSPEQCFTVEEGIKDKVRRGIVTEKEARLFMASFGFNNRFFETRGVPETVGPNNLFGMAKTAKTPQHDLDLTSKTSADWFRCRHSLERLQDQFAGLGFILDGALAFIPLTHTNRYLDDAGPCSSLDFAVRFFTGELDMSKWYLKELKTIAGNDGRTYTEARLWDQDGNMVATMTQQSIMRPPKSAARASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEJ1</accession>
    <name>H1VEJ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low temperature viability protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09691</name>
        <name evidence="4" type="ORF">CH63R_04264</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF38644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:preribosome, small subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        <source>
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            <dbReference type="EMBL" id="CCF38644.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="OBR11968.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
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    <sequence length="413" mass="46447" checksum="C1703A22EF841174" modified="2012-03-21" version="1">MAKGKKFDKKNAQHFTLVHRPQNDPLIHDENAPSMVLNPVPQKGGSSKGKHLSDLASELGSDAVSIRENEGEAAEYGVYYDDTQYDYMQHLRDLNSGGGEAVWVEAPAASDKGKGKQTSLEDALRQMDLEHKSEALLDESVLPNKNLQRSTYQNQQDIPDAIAGFQPDMDPRLREVLEALEDDAYVDEDDDIFQELSKDSREIDQYEFEDQFDYDDEDEGWESDGTAKPNKEYRSEAVPQLIPVEGEALPEHQNEDWLEDFKQFKKDQKGGKVQEKVTPSEIQSSIWTTTTMGGRKKKRKGALTNPSAYSMTSSSMVRTEQLTLLDARFDKIEEEYTSEMGGDDMASVSEVSTATSVAGPTRGDFDSIMDEFLGSYIKPGKRTNKKNRPQTGLEQLDEIRQGLGPARFRSKNY</sequence>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3-dehydroquinate from D-quinate (NAD(+) route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.24" evidence="5"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR02969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:quinate 3-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000610">
        <property type="entry name" value="Quinate 5-dehydrogenase QutB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF38769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="319" mass="35393" checksum="FF6AFB0DAA42C1D6" modified="2012-03-21" version="1">MASASAVQQVDDHIAVKIEQLDRHGYLFGQKITHSLSPLLHSTIYEGIGLKWEQMRLDSADMPLFLELIKHPKFYGSSVTMPNKVAIIPHLDELTDECRDVGACNTLFVRERDGKRIYCGTNTDVIGVRESFVQNVADPDAVYHNRPALVIGGGGAARSAVYALRKWMKATDIYLVNRDKSEVDAVIAECSARGYGDRMHHVSTVEEARELDAPGAIVACVPDFPPKTPEEIVAREVIVEFLNKAAKGAILEMCYNPTPYTEIAALAEDAGWQVILGTEAMIYQGLEQDRYWTGREVDQLPVQQVKEVIAAKLSQHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VI26</accession>
    <name>H1VI26_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calcium/proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_10593</name>
        <name evidence="12" type="ORF">CH63R_13975</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003749">
        <property type="protein sequence ID" value="CCF39879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151267.1">
        <property type="nucleotide sequence ID" value="XM_018308949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VI26"/>
    <dbReference type="STRING" id="759273.H1VI26"/>
    <dbReference type="GeneID" id="28873056"/>
    <dbReference type="KEGG" id="chig:CH63R_13975"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13975"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_0_1"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="424"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF39879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR02749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="577" mass="62144" checksum="4B4E50938BC2334A" modified="2012-03-21" version="1">MPDLTGSVNHFDIKRKAHGLSRRSQEQTWNPFRHVSWETGPSKRSTWDGANLEAQREGAAEDPETDEAIHHVQSEPAPRDSDTIRNSMGKETRSAAGSGSGDTAFDNKSEDAGVLRNRRADAAQDDQVPPEEEMEKPKKQKSGLIRHVKPKTPFTVANQLQRTLLSSYINILILAAPVGIAISYVGSINKIAVFVVNFIAIIPLAAMLGFATEEIALRTGETLGGLLNATFGNAVELIVAILALAEGKVLIVQTSLIGSILSNLLLVMGFCFFFGGLNRSEQYFNTTVAQTAASLLALAVASVIVPTVFDKNDGTDNPVHVAALSRGTAVILLIIYASYLFFQLKTHNSVFNEESQKVAAKPWSRGSLKEGALARGLAGTGARMAQTGVRGEGENERQELSRIMMQRPDEEDDEEEPQLHFFVAVGTLTLATVLIAFCAEAMVSSIDYVTKEGGISEEFVGLILLPIVGNAAEHATAVTVAIKDKMDLAIGVAVGSSMQVALFLIPLLVIIGWGMGNDAMTLSFDLFQVAVLFVAVLLVNYLISDGKSHWLEGLQLICLYAIIATCSWWYPATGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIF6</accession>
    <name>H1VIF6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_10690</name>
        <name evidence="11" type="ORF">CH63R_08595</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CACQ02003823">
        <property type="protein sequence ID" value="CCF40009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155592.1">
        <property type="nucleotide sequence ID" value="XM_018303569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIF6"/>
    <dbReference type="STRING" id="759273.H1VIF6"/>
    <dbReference type="GeneID" id="28867676"/>
    <dbReference type="KEGG" id="chig:CH63R_08595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08595"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_1_1_1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04816">
        <property type="entry name" value="PA_SaNapH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010395780" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="9">
        <location>
            <begin position="248"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF40009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR07074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="492" mass="52873" checksum="B621B0283BBA5D31" modified="2012-03-21" version="1">MKTTYLSAAAAALALASTTLATDLLTADKIEADIKTVELERILWNLNKIGRDNGGTRAFGTPGYKASVDFVLERAQTRFAKQMNTWLQPFNHTFEQTNAISVTGPDGVDVIVLSAEYNTATPLPCGITAPLVDIPVDDENGSGCLPEAFEGIDATGKLALVKRGVCAISDKIKNAKAAGALGVILYNQVPGNEIVKPTLGAENIGLLVPLGIITLETGEAWSAALAAGDEVTVTLIVDSIFEERETWNVISETKEGDPDKVIMLGAHLDSVLEGPGINDDGSGTAGLLQLMGSVKKYSGFPHKIRFAWWAAEEAGLVGSYYYTENLSSEEADKIKYYFNYDMIASPNPIYELASYNNSGIGPKLLADYLEANGKVVSDAEFDGRSDYAGFVELGIPTASIFTGEGENDPCYHLACDDIDNINWEALTLNTKAAGRALATLANSLEGVPPRADTTPVLRGRAGVLQQFRRWKKLAEHSRHGKTCSHNDVNKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKK4</accession>
    <name>H1VKK4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_11246</name>
        <name evidence="6" type="ORF">CH63R_02750</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02004278">
        <property type="protein sequence ID" value="CCF40757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018162541.1">
        <property type="nucleotide sequence ID" value="XM_018297725.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VKK4"/>
    <dbReference type="STRING" id="759273.H1VKK4"/>
    <dbReference type="GeneID" id="28861832"/>
    <dbReference type="KEGG" id="chig:CH63R_02750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02750"/>
    <dbReference type="eggNOG" id="ENOG502QQBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018250_0_0_1"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="106"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF40757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="449" mass="49282" checksum="A710E3CA2880D427" modified="2012-03-21" version="1">MAMAATVATPRAPTPRPKAPATVSFSTNPAPNIPTPLSTPGGDRSRPPLQGNPSARRSARSTPTDFLSDKATAAFIRRVLCSKHLAERGRATPAPIEELLPPLTSRNDVDLQLYALIAVILREYVQTWYSKITADDTFVNEVVQIIAHCTRALEQRLRKVDLESLLFDELPDLLDRHILAYRAAHDPVSRPPTEIDPREVYHSLCPLAPLSPIPRPEDPSSVTNQQENEAAYRQLLVQGVLAVLLPTEDLENDCLTSLVGQIFSELIIGNVLVNRLSQPWLIYECLIVLTRVLARGGSDPIEEGVTEALAGGSTPAVPKLVRRSWSIQRAFWSLVQWSFIAFTSIRLLITTLAMSSSLPPRSDGDAADKHDMTCQKSDSKTPNPATSSNEARPVQTKTPIVALKLWTCISDWIEMDTRMPWLSGTLSMLQLGAMEGPGRVAGLNGPMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLP9</accession>
    <name>H1VLP9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7872 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11515</name>
        <name evidence="4" type="ORF">CH63R_11172</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004518">
        <property type="protein sequence ID" value="CCF41152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152987.1">
        <property type="nucleotide sequence ID" value="XM_018306146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLP9"/>
    <dbReference type="STRING" id="759273.H1VLP9"/>
    <dbReference type="GeneID" id="28870253"/>
    <dbReference type="KEGG" id="chig:CH63R_11172"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11172"/>
    <dbReference type="eggNOG" id="ENOG502SQPP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030195_0_0_1"/>
    <dbReference type="OrthoDB" id="2501761at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057194">
        <property type="entry name" value="DUF7872"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33339">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33339:SF1">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25278">
        <property type="entry name" value="DUF7872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555189" description="DUF7872 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7872" evidence="2">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF41152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="425" mass="46966" checksum="2382175A17CA5861" modified="2012-03-21" version="1">MLFQLFVASAVLVLSGVKAAPLSSEAPDRGIATTLDPQDPDCEPGELSNTTWVERDVDAFLANASQHYTEYPYDNVQALGAYLGAPNFFCGVNTWCNAGQPCSPVTLPGWYALMGVQGWNNYVNNLNLALTYTATILSFKLGKLVNDLWPAQKDNVTGWRIFIAWVNGIINAFPTTAVYGATVGAWASAVQGGGIITGGMLVPPSGGDQFIRWSDLANQMGSQIDEYKKAVGAYAKTVIDAPIADPKWGINKVLSGGVFLTRDKNITQDDVDNWMYKSISTNAMGLLMQAQNVYIIRTFNKTECDPTPDAIFCEIQPNNKWTERRFQRRKSKKPENKLAKKLIETYGLTKEQVLKGPTDCFDASDYEQLINPWETLTEKGASLEPIQLCNFNVNVCNFDEAEDYGYAYNSDHTDGWCEAQGIDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNA3</accession>
    <name>H1VNA3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_02656</name>
        <name evidence="15" type="ORF">CH63R_04696</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004879">
        <property type="protein sequence ID" value="CCF41707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160917.1">
        <property type="nucleotide sequence ID" value="XM_018299671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNA3"/>
    <dbReference type="STRING" id="759273.H1VNA3"/>
    <dbReference type="GeneID" id="28863778"/>
    <dbReference type="KEGG" id="chig:CH63R_04696"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04696"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_2_1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00062168"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR12400.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="143" mass="16858" checksum="E0FBC52B5E7501D8" modified="2012-03-21" version="1">MLSFILIQNRQGKTRLAKWYAPYSDDEKIKLKGEVHRLVAPRDQKYQSNFVEFRNNKIVYRRYAGLFFCACVDTNDNELAFLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTX8</accession>
    <name>H1VTX8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_13317</name>
        <name evidence="12" type="ORF">CH63R_07068</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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            <location evidence="1">Cytoskeleton</location>
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        <property type="entry name" value="DLIC"/>
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            <end position="24"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="78"/>
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    </feature>
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        </location>
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            <end position="539"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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            <end position="77"/>
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            <end position="503"/>
        </location>
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            <end position="513"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF43686.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OBR08303.1"/>
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            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="539" mass="59123" checksum="41117757B61051FE" modified="2012-03-21" version="1">MTASANRVSTYTSASAGSDARNGERKDLWSSMLDNVASGKRLPEKNMIVLGGSPESQREFVESLSHSSEKRSLDRHGSKTPPIANSFALGYTYYDVLDADQEDILARISLYMLSTPAEAFPKLIQPLITPESIPNTLMVILLDWSTPHLWMRQLREWILFMRSILENSSHECQATMEEVMVSWRDRGRGGGSTNLDGTGAVTSEGDVTLPLGPGEWEEGIGLPLCVVCQNAEKMEAFEKTQGWKEGDFDQVLQYLRTALLRHGASLIYTTPNVPSSMPTLIHSSLGITSLLKRQPLKHNVIDRDKILVPPNWDSWGKIRVLRDGFDVETTSQGWSHDLQSTFPSPAMTTEGLNTLAKAKADGDYSGEVWSSAVAPYEDWIRDLSNAGSAISFAGRDGDPSQLEMSSTDTQEFLGSSLQTLESHRSRSSDDKKTDISRSRLGQRADESDSSALQAGTDGKVSQHIGPVQFNMGGIQVDADDMVQRLKDRQAFSAAQDPTTPPADAAEENPDEMDNDKLQAFFSGLMNRKQPANGSPRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1S7</accession>
    <name>H1W1S7_COLHI</name>
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        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_03871</name>
        <name evidence="10" type="ORF">CH63R_14229</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008690">
        <property type="protein sequence ID" value="CCF46440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151521.1">
        <property type="nucleotide sequence ID" value="XM_018309203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1S7"/>
    <dbReference type="STRING" id="759273.H1W1S7"/>
    <dbReference type="GeneID" id="28873310"/>
    <dbReference type="KEGG" id="chig:CH63R_14229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14229"/>
    <dbReference type="eggNOG" id="ENOG502R3ID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028200_0_2_1"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF46440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="40446" checksum="02E0AFCE9E1FAB37" modified="2012-03-21" version="1">MAESQSGTVVTVAVVFAVLTFIVIALRVWARAILVRSFGPDDVLIIFAALLSWAFIAATIRATHLGLGSHIAHVMERGTDNFVMYLQTVWLSSIFYNACLGFVKVSALALYMRLGDFTLRKLAAVMLGVVGCQAGANVLVCIFQCSPVQAAYDIAILAADKKCIDINAFYLANAAVNILTDILTYTLPIPLVIKLQVPKQQKVGLGVILCLGLFACISSIIRITFIPDMLVNEDATWAISQPMYWSVIETNIGILAASIPSMKVIAKRYAPRLLGTSSNGHGSASNGRQSGFRMMSGSNNIKSSSNGEKAGTALRSLSKGGFNTKIDHGDVDNSSEEALNHPPSGKIRVQTQVSMQYDEGSDVGDSKQPFQKRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3T2</accession>
    <name>H1W3T2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04064</name>
        <name evidence="4" type="ORF">CH63R_08105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009412">
        <property type="protein sequence ID" value="CCF47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157857.1">
        <property type="nucleotide sequence ID" value="XM_018303079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3T2"/>
    <dbReference type="GeneID" id="28867186"/>
    <dbReference type="KEGG" id="chig:CH63R_08105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08105"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055868_0_1_1"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="308" mass="34403" checksum="3DC5BC4E11F633DC" modified="2012-03-21" version="1">MSSPGDSIEEEPPVIEPYEILGLEREATADQIKSAYRKAALKNHPDKVTDDKRDEAKEKFQSIAFAYAVLSDPARRKRYDATGSTSESIVDSEGFNWSDFYHEQFRDAISADAIENFAKKYKGSDEEKDDVLLAYTEHKGDMDKIYETVMLSNVLEDDERFRTIIDDAITSKDVPTFKRYTKESKLSKAARVKAAKGEAQEAEEYAKELGVHDKLFGGGKATKGRKKAKEGGEDDLAALIKSNQQKRAGFLDDLAAKYGATSQPKKGKRRAVEEEEPSEEAFQAAAARLKKPKTEESKPANAGRRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQT5</accession>
    <name>A0A1B7XQT5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150643.1">
        <property type="nucleotide sequence ID" value="XM_018309400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQT5"/>
    <dbReference type="GeneID" id="28873507"/>
    <dbReference type="KEGG" id="chig:CH63R_14426"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14426"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="772" mass="87636" checksum="B2D86EFFF8931E7F" modified="2016-11-02" version="1">MAQMFGAPVPFKSPADVRRDAQQLSVSILSSYQTLQAILARHEATIQQRWSRKKRHQRLDTLTRAWGHGMPTVHRPDFEAFRKESNRQVHNSTVARDCYVWPYINEEDLVKPKSLLLLLHARGHNHPSEFAGADFEAMHLGVITKKIIPVFLNEYVMILHGARNAKEYGKLLAWSEHPDAFDWMCSRKQFMPGEGLVVLEAQQRLLGFLVKCCEHILHDVPSTMLTTGAIPLELGHQLKSDNEKGGFASLTVMAAEAPYRPPARLDFNRIESLLRARLEVAKDHVWALREDPGYFAEQLAEAKEHRQEMLKDLNGDTHPSLAHPRQHVFWGRVIKSCIIAANLELEAYSQLHRQAKELQQLHTKYAQSLSPTEDLPGEFLGPILKFRHYLNQTAKGPMQELKQKVVASPPMRRFFVREPPVSITTSMIQVRSKSGVKMSKTESHLIWLLRTLWDDGQDLFFVGLPLLLDELERLLQAEPQAKELVSAQVARDIGNLSILSQCINQLEMYHPWARGFESMMVDREAGIRQEFTERTKPWARMLAALDEKNLHRVAELGNPSGNKFAYPSEKRRNKENTEALRQAESNLDDFWAAIDRLLYDGCGSLKGTALESVLSQQRSLQRTPEWVQQPDGATIETQQHRSTQAVVESIYKPLSTLYFELPGRHQGGSEQTPIPPKRKTKTKSATAEETPQGNTAGLRTIASDDATVPLIQVDARALKVFRALFFDPAVTSTPGEVQWKDFLYAMTSTVSRASPVWESSIRRSKAARQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRC4</accession>
    <name>A0A1B7XRC4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150828.1">
        <property type="nucleotide sequence ID" value="XM_018308510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28872617"/>
    <dbReference type="KEGG" id="chig:CH63R_13536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13536"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2133"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1859"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1863"/>
            <end position="1876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2677" mass="291625" checksum="ED797A58D5861B59" modified="2016-11-02" version="1">MQLIRHVEKHEDFFLPSPDDVAWDLFEKYHEKESASVFSEIEAVYPATEIQRDILHEDVQWAEVELFSGKPASFGLESVFNAWSSLASHHICLRSYITTNHETGQPQVVVLRRIEDIRWHNPDKRNAPHESPAYVTVEGTRRVAGGVSLVLHFHRALIDTTSLHMIKLDFALQVHGLPSIESAGFATYTRYLDQQRRHAEAAKLFWSETLADAVPRPVFGLDARSSAGTTTTTTTTTRDRHGVSAVISGRDLARLNDLEASLHGLASWRQTFFEVVWAHVLGAHTGGGGGGGGEEVVFGTVRRDDNFVGSSSCVGCVDQTYPVRFRLGGAEDRRTDRTTVQDAARALDVYHSQAGRHAFVGLNEIRRRSRHGHAIETAVSYSQTTNAPCIAPGLRSFPIVLCISDAGVLRVTLKCESYIPLDEIEVVLQHFVAGILNASSGMSLAKDYSLSDIDLVSEDEKQALLSQSVSRRTAEATTIPALFEKTAALHPSRVAVEFEGKVSLTFSELNSQANMLARRLKLDKGSLVPILSERSPFLVVAILAVLKSGAVYTVLDPDTPVSRLEQIVDDCKPAAILASRRYINVLAGATDIEQVLSLGSAASAPSPGELDNNNLEVDIDPEDLCYIIYTSGSTGKPKGALLTHRAATSGMAHHSLNGLGRWLLFYNPSFSAAQRTILGTLVHGGTLVLASKESLTGDLVGVINTLSVDSLGITPSALSLLKPHEVPGLRQITLVGEQIPQDLVETWSALGGENLRLRNTYGLSECTQLNFGRELRRAQSGGDAVVNPRVVGSPADTTDAFILRQGTTELAPLLVPGELCLAGPQLAEGYINEPALTARVFIDNPFGPGKLYRTGDRARRLADGQIEIQGRVDMQVKINGQKVEPAEVDRLLRGVVGVFDTSVTLAAELGPEDRTVLAAGVVLARDVPFRDAVITAREHLRERLPVYMVPVIWLPLEEIPKNANGKINYARLRELVRELGTVGFTTLMDAAGDATPGANEVLDEVETAVAAAWSAILRVDASIIRKSQTFTDLGGTSIQAIQVISHLRKAGFSVELSDLLDENTLEVVASRSVVFNAETQHDPEPFSLVADAAFASGLQRDGGTVDAYPVTPFQETMLASLGDSPDPYTYSRAWDVGHVNLELLRQSFEQVVSRRELLRTVFVPHKRSFIQVVREHIALPWHHAVSDSLESFLSQEKAKTQQWELDRPLWKVTVVADHVLVVTMHHSLFDFWSHRFLYDDVAAVYSGKAVPPRPRFSNFVKHLLGQETSSSDAFWSTYLEGADLVRLNHSPLDQTYKTEASLGFSLSKRAGGVGLTLGSIVYGAWAMLLSRHLSSGDVTFATTISGREAPVSLVHDIDGPTMTTVPQRVQIAPDATLRDIAKSTLSGFTRLLKHSQVGLLGALRAGNLSHTTIDTLVNILVKNEGDDEDDDENVDDGTKNSRDVFRMHGERPQWSSGSDTTVLEVEDAGDATVVRLVSTMEPRRLDFIRDSFLRLVTLLLEQPETKLALTTITDEAEHDFVYNTLANRRTLHVPEADFLHAAFERIAREAPETAAIDFNGEEVVSYGALDRLANRFAHVLFGRGARPGDLVPLMLDKSVDMMVAILGVLKAGAAYVPLSPDNPGERNAFVVADTKARLLVAHPRHADFGLHVRDLHGVETLIMPSHHDDEETISASTRDGHDDWDAAPVLVGVGEEQGQEMMITPDALAYLIYTSGSTGMPKGVKVPHRAAAAAVTSMAQVEGRHRGTWRTLQFANYVFDASVQDFFNTLSTGGTLCMAPTETLLSDIAGCVNRMDARQAIITPTVAKLFGPADVPGFETLIVGGEPLTPDVVEAWGPHCQILNVYGPTETSMVVTTKDVERPSSLSSSSSSPDAQDGGDGGGRVHGRGHLRRIGNIGAPFPTVMAFITSPDGEALVPYGAVGELCIAGPQVTQGYMNRPDLTDAAYVESQHLGTRIYRTGDLARWLPGGEIECLGRKDNQVKVHGHRIELGEVENAVRRSGLVRDAVAVVANVHDKTHLVALCVFDEAVAAAAALDNDGDNDDDVVVGSGGGGVQDPAPFRASVAALRESLGSLATYMIPKFVIPMKTFPKLPSRKVDRKALKKTVDALGRDYLAQCVLETPSSGEEHEVVPVQTPAEETLELVWAGIFGVSTGNIGREANFLALGGDSISAISLTGQLRRAGYSLTVLDILKSPRLKDMAAALKTLDVGKSIAKRVFEVPETVKTAVQERGLIWDEDVEYAYPCPPGQSEFLKQGSRDSQMWALQTVRRMTPDDVDPETWIEATTRLTEVNDILRTTWIRASSSSSSSSSSSSSPTEDDWVGVVLRSSQLNLTRMALESEEEASDFIEDFWQTRFEFGRSFIKYAVITHADSSWDLVIKMDHAVYDGTLFRVFDDHFGSILRGETVPPPPVPFRDFTQHVFQEDKTASLDFWRSKMAGLGPLDQRLHGRDLAALASPKITSSLRREIDTANIDQAAGRLGVTPSVIFQGAFTLWLAAATGTADVRFDYLLSGRNVALPDPQSINGTLANFLPFRTPVRPEQTVRGLLAALQDDFWAVTENGLVGLDDVYRASGLSRGEHGNRVLFLSQPFEPAARDDPNGRYRWLVMAKSRVRMYQPHALVVEVSKSLGDRHVLKVMYDGAVLDAAAAERIADDITALIGVLSDGEMSGVALDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSA1</accession>
    <name>A0A1B7XSA1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151122.1">
        <property type="nucleotide sequence ID" value="XM_018308804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSA1"/>
    <dbReference type="GeneID" id="28872911"/>
    <dbReference type="KEGG" id="chig:CH63R_13830"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13830"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="185" mass="22149" checksum="8B430F16DC0050DC" modified="2016-11-02" version="1">MLSPRPPPLTCWNIDRHLDHLQRKPDHGHHLLHSAYRHGAPTRHLPRCSPDRRHQAIHRPEASPRWPPEAQQRRNQPRQLRRRHCLQPDAGRAPRPAVRQRSASRWHASHGLEHLLVLVHLDLDLIHEHLPHRHHHHDVDHHDIHQHRLSGFDDPVRTRTVDNFRLTKSWTVLPRRRRRSRQCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSU6</accession>
    <name>A0A1B7XSU6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_14030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151322.1">
        <property type="nucleotide sequence ID" value="XM_018309004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSU6"/>
    <dbReference type="GeneID" id="28873111"/>
    <dbReference type="KEGG" id="chig:CH63R_14030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14030"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32259" checksum="264CFE79871D55F7" modified="2016-11-02" version="1">MNLIYPPKGLYISDLLRPSRTRFCCPSLTHTLSTLNQLLHSFFYFHFYSPSPTCVFYPFPIKMQFFKFGLVPLLAALPGALACNGYTGGVPKATGTVSSKSYIEIKSGQVFDGQWKRYDRGSGACGGQSEGDYKDSVFYIQAGGTLKNAIIGKNQAEGVHCNGHCTLEFVWFEDVCEDAISIKNDKAGKQTWIIGGGAYHASDKVIQHNGCGTVNVINYYVEDYGKLYRSCGNCKSQCKRTVNLEGITAKNGGELAGINSNLGDRATLKNVCADAKTKCQKYNGCAGGCEPKKAGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT54</accession>
    <name>A0A1B7XT54_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151466.1">
        <property type="nucleotide sequence ID" value="XM_018309148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT54"/>
    <dbReference type="GeneID" id="28873255"/>
    <dbReference type="KEGG" id="chig:CH63R_14174"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14174"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="91"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="557" mass="61132" checksum="FF5795617370F1A3" modified="2016-11-02" version="1">MANVDRDTEETPRTTDLFSIPCGCPKLVGVVPPLDNNSAITYRYLSFNTLLPKPADIVFHGAAGSSTKPTVPDLSKYKSPLQWPRSRKSLMLALSCIATFLTAYTAGSYSPPSYIMADDLGTSQLLVLVGITTFCVGFALSPMVLAPLSEIYGRYPVFVVSGVVYVAFQAVCSVAPTLAVMLIARFLVGVGGSVFSSVIGGVIADLWPKEQRNTPMALFSGAVLAGTGAGPLVASIVVKRMGVENGTMAWKWIFWHQVIIDTVLVVALAVLFEESRGSVILSRKAKDLNDWYQAIEDSGYYTMWPEDMEETSGDTDTTSESGDIRWCSYSGSANHGSTCDSSWSCPARCRPKRLRWLVKDDEKQESLVKLVSVSVSRPFHLLFTEPVVFFFSVWCAFAWAVLYCTFGSIPLVLSRTRGMDIEQSGYFFIAMIVGSVVATTVGVLQDKLLRLPQWRADSPLNEPSRFWLFMRHWFPVDAPESRLYFTCITAVLLPVGLFIFGFTANQKFHWVAPAFGVGLATWGIYSVRAAGTYSAGFSHSSPAPCFGILERNTQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTU9</accession>
    <name>A0A1B7XTU9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151710.1">
        <property type="nucleotide sequence ID" value="XM_018307293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTU9"/>
    <dbReference type="GeneID" id="28871400"/>
    <dbReference type="KEGG" id="chig:CH63R_12319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12319"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="74" mass="8056" checksum="5CCD618138C407B4" modified="2016-11-02" version="1">MTAERGSFSHGGKYVGMLCRRSGISQGLAMVRRRETLRVSSANRALYLPVREIKSKPAFVFRGGGNSTAPLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU60</accession>
    <name>A0A1B7XU60_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151830.1">
        <property type="nucleotide sequence ID" value="XM_018307413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU60"/>
    <dbReference type="GeneID" id="28871520"/>
    <dbReference type="KEGG" id="chig:CH63R_12439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12439"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="70" mass="7562" checksum="7B4E775C7A3AB650" modified="2016-11-02" version="1">MCPCDPVGAVPVVFEPLRIDKLSQRTIVRSKTGRSMGLEATMTAMPDCSTPLTEAEANPRVMLTKSAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU85</accession>
    <name>A0A1B7XU85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151831.1">
        <property type="nucleotide sequence ID" value="XM_018307414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU85"/>
    <dbReference type="GeneID" id="28871521"/>
    <dbReference type="KEGG" id="chig:CH63R_12440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12440"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="57"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="239" mass="26107" checksum="57BD2057C05B981A" modified="2016-11-02" version="1">MSAESMDVADSLPIFLQAQENATAKITERYPPLTRDGASLVITAGIMMVLTTLWTIMRLVSRRMTGVPFHLEDYFYFVGQFASFSASVVIGGAGHDIGVLDPEVHVSHFVKVFLVAQVMYASELLAIKLSIIVLMQRIFSRSSPWFRTTSWLAVGLSCAWALYTGLLGFVICRPVRSAWDISVAKTGCGDYTVAFSAVAVFDIVTDVVIVVLPIRVVSGLQMARAHKLALYVVFGAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUH1</accession>
    <name>A0A1B7XUH1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151902.1">
        <property type="nucleotide sequence ID" value="XM_018307485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUH1"/>
    <dbReference type="GeneID" id="28871592"/>
    <dbReference type="KEGG" id="chig:CH63R_12511"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12511"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="219"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="352" mass="39171" checksum="A3D885A0E7403083" modified="2016-11-02" version="1">MPWDLPDDLVQDLKTTSPGIQIITYRVGFYNKAPPVEIPQATWDRVTALFTWMAFPTPEKAPSLQYVQLLAAGCNHVSDMPIFHGTDVVFCTANGVHPPQISEWVIATFLSFQHHLYEHWENQKRRTWVMPEHDEDTQDAVGLRILQPAHIHDPQRGVLGYGSIGRQCARLADALGMSVYAYTARERPSAASRADDSYVEPGLGDPVGEIPSRWFHGRAQLNDFLAEIDLLVITLPLTPATKGIIAREQLRALGTRKAFLVNVARGAVVDTDDLVAALNEGTIKGAALDVTDPEPLPPDHPLWTAKNVIITPHVSCNSTHYNERVLRILAENLKRRAQGKRMLNVVDKSLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVA0</accession>
    <name>A0A1B7XVA0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152191.1">
        <property type="nucleotide sequence ID" value="XM_018307774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVA0"/>
    <dbReference type="GeneID" id="28871881"/>
    <dbReference type="KEGG" id="chig:CH63R_12800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12800"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="103" mass="11153" checksum="D6E025D122AA849A" modified="2016-11-02" version="1">MKTPRSGRGGERKGEKEGKKGLSSLAHVGHHLGRKETTNFLALWPAPCFPTSGPRGIHRMADGMSILSHMRCLCEMERKRGGGSKEEGHGSTPASNNRRASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXS5</accession>
    <name>A0A1B7XXS5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_11265</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153080.1">
        <property type="nucleotide sequence ID" value="XM_018306239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXS5"/>
    <dbReference type="GeneID" id="28870346"/>
    <dbReference type="KEGG" id="chig:CH63R_11265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11265"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601170" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR04562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="35250" checksum="11BDB9FBC101C49E" modified="2016-11-02" version="1">MGHLSPSSLLLALAATVSAHGHVNWLVADGVAYRGWDSPAFTYSPPAGPVVGWKIDQPDNGFVEPANFGTNDIICHKNGVPAGGHATVPAGTKIQLVWDTWPDSHKGPVIDYLAKCSGDCETVDKTSLNFFKIGAGGLIDMSLPSGNWAADRLIANGFTWTVQIPPTLAPGNYVLRHEILALHSGGNPNGAQAYPQCFNIKVTGGGSLAPAGVKGTALYKADGPGVLFNLYTSPLVYQMPGPTLVAGLPSTVAQSTARPTATSSATPPGATGGSGGGSPSTTLRTTTVPVPATTTRAATVSTTTSAGGGGGGTVPKFGQCGGQGWTGLTTCAAGSTCQALNPFYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYJ5</accession>
    <name>A0A1B7XYJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153337.1">
        <property type="nucleotide sequence ID" value="XM_018306496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYJ5"/>
    <dbReference type="GeneID" id="28870603"/>
    <dbReference type="KEGG" id="chig:CH63R_11522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11522"/>
    <dbReference type="OrthoDB" id="4851229at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="433" mass="48954" checksum="C710FAD8C6141641" modified="2016-11-02" version="1">MSEPPSPTSPSAAAASAGDVLERRKTEVIRKLAAHVPSDDGDPIRLKKLGIIEKVLASFEDPNMNSDYLDEINNFHSYRYQPMTSTLAYLDNIEQRLQLLKDIKTTKLKYTDPEVPPKALPAELITHVVWAAFMAAPIDALQTLLNNMQSGRVGYHALTDALGQVETNLPILIHIKRCVLLGTTDPHVAHIFSHAAISHVSMYRSKLNCLATIWGDARINRYQEAHGESLDVPQNMLSLNYTVHHRWDKAQVAFEPIGQVNNSTIRVRLHLLEDTKLRSLKRKRDSSRDEFQWRNDLAQDPRETLKPFKDQFSSPSPLELRLVSSVTQHIVRDGHIFDIKARNPAHLPSYELLDLQYRICLMATLLGGGETSDEYLSESDADNEGQARLSDSKKILVDQWFQRMETDPVDLATAVIERLEEEKAIEEAWGEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ18</accession>
    <name>A0A1B7XZ18_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153523.1">
        <property type="nucleotide sequence ID" value="XM_018306682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ18"/>
    <dbReference type="GeneID" id="28870789"/>
    <dbReference type="KEGG" id="chig:CH63R_11708"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11708"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="232" mass="26160" checksum="FB1D2E23B6A8F860" modified="2016-11-02" version="1">MAEDNLSTNSGEFWLYGYGRIPGWVTGYVRRFWQASNPIFSQDHRGTPEAPGRVVTLIERSFWERLTDHHDSAPDRVWGVAYRIKADKVAEVKDYLDIREINGYTIHYAPFFPADGSETIRTLVYIGTPDNDQFVGPQDPQELATHIRKSRGPSGLNIDYLLGLEKALDELSPESGDVHITDLSDRVRTIMAAELEGSGHVVETSQPPPSAVSNNFQQEHSIEEQEETEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZG5</accession>
    <name>A0A1B7XZG5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_11871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153686.1">
        <property type="nucleotide sequence ID" value="XM_018306845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZG5"/>
    <dbReference type="GeneID" id="28870952"/>
    <dbReference type="KEGG" id="chig:CH63R_11871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11871"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="368"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="702"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="846"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1087"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="767"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="918"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1087"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1140"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR05168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1152" mass="123140" checksum="7167086B30CBAD34" modified="2016-11-02" version="1">MGFLGVYKAVYDYVPQAAGELTIKDGDVLYVTEKNAEDDWWKAKKKASADDEEEPEGLVPNNYVEEAQPVATARALFEYTRQTDEELSFPEDAVLDVYDTSDPDWILVGLDGDFGFVPANYIELGEVEEPVALPSPPPALPSRSISAATDTETYSERSESTYSPSSSQANNPAAALAGVMAGRSAPPPRAATPPMMPQSPASEPSDDETIKSPALPARPISQAAPARIQSQRSMDTHLYDNSPEIIEEPPYRAPGGFHMYNINEMVSVMGKRKKMPTTLGINLATGNILIAPERASDGPSQEWTAEKMTHYSREGKHVFLELVRPSKSVDFHAGAKDTAEEIVGALGELAGAVKAEGLREVILAGSGKTQKKGQVLYDFMAQGDDEVTVAVGDDVIIIDDSKSEEWWQVRRVKNGKEGVVPSSYIEVTGSITPPSGTTGLNAARSTVEQNRLEEIRLTKEAVKAAQRDSSQQVGPGMPLPKRGSSLMARENGNNYGQRSKRENGRGEGGSRSGKSSKHNMLRSMHGASFADVFMTEPDPAKVRTWTDRSKSFSVDAQFLGLKDGKINLHKMNGVKIAVPVAKMSVEDLEYVERVTGISLDEDKPLSNVKKARASQANTARDSPSAGLGASVGQPQKPEYDWFQFFLSCDVAVGLCERYAQAFAKDSMDESVLPDVDASVLRNLGLREGDVLKVMRTLDHKFSRTKSSADKINGEGDGASGGLFSGPGGALRNNTRKGRPAPAVQTSDVVDPKAFAAKGTGPGEDANSKSPASASATPATSTTTGGFDDDAWDVKPSKHPQEPPRPAPSSASATAQSTEQPAPAAQAPALTGSMQDLSLLTKPLEPQRTAQPTVPSSAVSQPPSQASQPTGATPSFFDTIRPNPTGMQTPQQTMQRQRPAPPVATTSPGSLMPPPPARPLSAPQSAQPSAFAPPPLMPQMTGVSSQAFQTQVAPPGQSLNDISQARLQQQYTLQQHQIPQQQMNPYPIPQQQPVPGVMGFNPGMQQAGGQFMQQMQPMITGAPTQSPFADPQRQNQFSPMQSQPTGFSGQFGAMQGFNQQPTGNINSYLPPAMEPQRTGMPGFQPQQTGMSGFTSMASAGSMQPSTQPLMPQQTGPPPPVRFGVTGDAKKLMPQATGRRANLSQATPNNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZH9</accession>
    <name>A0A1B7XZH9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153659.1">
        <property type="nucleotide sequence ID" value="XM_018306818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZH9"/>
    <dbReference type="GeneID" id="28870925"/>
    <dbReference type="KEGG" id="chig:CH63R_11844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11844"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001075">
        <property type="entry name" value="Zinc finger, C2H2-type/integrase, DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="299" mass="32251" checksum="184C01E17EB6438B" modified="2016-11-02" version="1">MHARDATGRQVSLLNDEPAVQSIPQRPSYHAASQVISQPFHPAPRSNSSSPHTPELLRSDSYDSNASSDPLSPMTPTSYDPSRASAFPGQPIYDEYDMPSKRPAYANSSRANSYEDDSSATSPLPERPGKRYPCRYRDSHGCEKTFTTSGHASRHSKIHTAEKAVQCTFHGCQKKFTRADNMKQHLETHYKDKSRSTASAKATARSSLGGLSSSGRRSSSSSARVAASTRAPRDQPMWEGESPYGYPPGQAPLPSPAATGAWDMRGLNLPLLNRPSAVRTPSSGLDALAMAVACQEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y006</accession>
    <name>A0A1B7Y006_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153873.1">
        <property type="nucleotide sequence ID" value="XM_018307032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y006"/>
    <dbReference type="GeneID" id="28871139"/>
    <dbReference type="KEGG" id="chig:CH63R_12058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12058"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="59" mass="6682" checksum="DC7EA74A20552489" modified="2016-11-02" version="1">MKVSYSIITTLVGYTLVYGADGINYESISPATDEQDNKAWAEYIYLMTRLRGAREIESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0J8</accession>
    <name>A0A1B7Y0J8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154059.1">
        <property type="nucleotide sequence ID" value="XM_018307218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0J8"/>
    <dbReference type="GeneID" id="28871325"/>
    <dbReference type="KEGG" id="chig:CH63R_12244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12244"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="98" mass="11734" checksum="A376AEAE98AD76A1" modified="2016-11-02" version="1">MRWWKSSRRFPLSRTSSRRRPSSAPPSSPRSGTSKRPPWRPTVSSQRWAKPCSPPRRRRRRRRRPPRRARPPTPSNQTKACGHFFLQMIFLFAWLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0V7</accession>
    <name>A0A1B7Y0V7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bnr repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154170.1">
        <property type="nucleotide sequence ID" value="XM_018304746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0V7"/>
    <dbReference type="GeneID" id="28868853"/>
    <dbReference type="KEGG" id="chig:CH63R_09772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09772"/>
    <dbReference type="OrthoDB" id="3701586at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601251" evidence="1">
        <location>
            <begin position="27"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="49838" checksum="58072C266E09956E" modified="2016-11-02" version="1">MSPSVSFKSIITIGLLSASQWLPAWAAPPPPGNLWRVWPPIDYSDKIYAGWGQIPVEKEVQIYNGVAENRTYAHHPELFAVGANVFLIYSSAPVDEDSMGQDVWISASGDGGLTWSAGKSLMPAALLPNQTELHDWKYWCDRGIAQRAWQALSFVRLPDGELYAIGQSGSRWCPGRWATAGRIARKISLEGEPLEDPCWLEKNEFTESQLYAETVYGTEYGMRSCARACEINAVLTKPDEAPAWSPWLYNNGLFAADGTHQMEEQTLAVWHDDADSPTGGYWQRHWRDISPERENTHSVWVEYNEDPAGEGWYPKVKEPLGNKIYKTNIPDAKTKQFLARLDGGKGDRVLLSNPRYNAADPQRQPLTLAVSSGADQTYRAIGVLRTNATREIVPDTRGGIKNRAFGFSYPTAVQVGDKLLVAYSENKENIWVSVVDVAALPKEGDACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1D5</accession>
    <name>A0A1B7Y1D5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-like protein ced-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_09948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154346.1">
        <property type="nucleotide sequence ID" value="XM_018304922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1D5"/>
    <dbReference type="GeneID" id="28869029"/>
    <dbReference type="KEGG" id="chig:CH63R_09948"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09948"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="209" mass="23262" checksum="2DCA21DFB363FA6F" modified="2016-11-02" version="1">MAQPGVQSLKGYKANGLLSQCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSASVMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSIVSPPSFDNVKAKWYPEIDHHAPNIPIILVGTKLDLREDPNTLESLRQKRMEPVSYDQALICAKEIKAHKYLECSALTQRNLKSVFDEAIRAVLNPRPIPQQKKKSKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1P1</accession>
    <name>A0A1B7Y1P1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_10055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154453.1">
        <property type="nucleotide sequence ID" value="XM_018305029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1P1"/>
    <dbReference type="GeneID" id="28869136"/>
    <dbReference type="KEGG" id="chig:CH63R_10055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10055"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601270" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="404"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="61751" checksum="8DCA4BCA3A9AD7C9" modified="2016-11-02" version="1">MKPSSSHSTWRCYASLLLLAELRSTSAATVPQFVFNPHAGSSGAVASEAVECSKIGRDLIARGGNAVDALVGTTFCVGTVGMYHSGIGGGGFVVVRDAYGNYESVDFRESAPAAAFQDMYKGNIEGSVYGGLAVGVPSEVRGLEYIHKKYGVLPWKAVVTPAAQLATTGFRVSEDLVRYMANAINGQYNFLVEDPVWAEEFAPNGKLLQLGDTIYRKRYGAHTSTLAKIAEEGPDAFYSGPIAESIIATVRATNGSLTLDDLSSYKVVTRPSLSISYRGHRLVSVGSPASGAVCLNTLKIMEQFDPSESADTHLGVHRFDEALRFAYGARSLLGDPDFVDGIGPFEDTLIDEATAKDIRHRILDNQTQPVDRYDPHGMYASEGFGTSHIVTADKSGMATSLTTTVNLLFGAQIMDPLSGVILNNEMNDFSIPGVRNAFGFEPSPANFVRANKRPLSSITPVIVEHPDGTLYATVGAAGGSRIISSTAQVAWHVLEHGRTMKQALREPRLHDQLMPNTVTFEYAFDNDTVASMIEKGHDVTWVPEGRSAVQGIIFDGGVFEAASEPRQKNSGAFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y279</accession>
    <name>A0A1B7Y279_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154636.1">
        <property type="nucleotide sequence ID" value="XM_018305212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y279"/>
    <dbReference type="GeneID" id="28869319"/>
    <dbReference type="KEGG" id="chig:CH63R_10238"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10238"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0401">Integrin</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601264" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="280"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="521"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="823" mass="87688" checksum="BD6456EBD8079383" modified="2016-11-02" version="1">MVSFRTIAAALAGLASFSQQALAHSTQRNPLKYVTILEDAVFHSPSQHCHALSHFDLTFSLHDKQQNIRLALEPNHDILHSTLEVNYMGGDGKIHTTETVDRSEHRVFRGKAFVRPEGRPDDWRHAGWARITVHRDGADPIFEGAFRLDDDHHRIQTGANYHARKHREDPDAPSRQNPGEYMVVWRDSDIIEYWTDKEDLKKKREIFGRSSCNSDSLDFNNDYKIVDARDPEPLQSVSSNSLFGRSIFGRQSIDGSTGNNGAGINLVSTIGQTAGCPSTRKIALLGVATDCTYTAAFNSTQAVRQNIIDVINAASEVYESTFNISLGIQNLTISDANCPGQASSTAPWNVACSNSVTITDRLNLFSAWRGNSNDNNAFWTLMSTCGTDSAVGLAWLGQACTDGAQTSGSGNNNETVASANVVIQTPSEWQVVAHEVGHTFGAVHDCMDTTCSNGDSGMNKCCPLSSGTCDAGGAYIMNPSTGTGIRAFSPCSIGNICSGLQRSQVKSTCLANNRDVNTITGSQCGNGIVEAGEDCDCGGTTGCGSNRCCNPTTCKFTTGSRCDPANEDCCNGQCQFASNGTVCRQSTGSCDPEEVCSGSASTCPSDEHKDDGDSCGNSGEGLTCASGQCTSRDQQCKTAWGSRTNASAVSSCNSGSSDCMISCNVPSISNGACVTMNQNFLDGTSCTGGGKCSNGLCQGSNPGSEIWDWIQNNKGIFIPVVIVVGLLILIVLFSCICGACRRSRSRTRAKRLQAVPVPQMSNGNGGWNNYGGAWSNPNIPPPPPAATRPGGPPPYQGSYHGSYQGGHQNDGWGMNRTQSARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2M6</accession>
    <name>A0A1B7Y2M6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Urea carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_10383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154781.1">
        <property type="nucleotide sequence ID" value="XM_018305357.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28869464"/>
    <dbReference type="KEGG" id="chig:CH63R_10383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10383"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004847">
        <property type="term" value="F:urea carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053844">
        <property type="entry name" value="AH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014085">
        <property type="entry name" value="Allophanate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014084">
        <property type="entry name" value="Urea_COase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02713">
        <property type="entry name" value="allophanate_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006043">
        <property type="entry name" value="PRK08186.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02712">
        <property type="entry name" value="urea_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21986">
        <property type="entry name" value="AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="617"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="736"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="1745"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1734"/>
            <end position="1756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1823" mass="195748" checksum="53A87726AE3FAF26" modified="2016-11-02" version="1">MGSTIQSTFPLTVKEWRETQEAGDGLARLLSLRESEARLKSNAWITLATPSQIEEQWAHAESLRSSGASLPLFGVPFAAKDNIDVASFPTTAACPSFATGPVDKDAAVIARLKTAGAIVLGKTNLDQFATGLVGTRSPYGPVSNSFDPARVSGGSSSGSSVVVARGVVPFSLGTDTAGSGRVPAGLNNLVGLKPTRGALSTTRVLPACRSLDCVSIFTLTVDDAETVLAAAEGFDPEDSFSRARPDTPSTVKGHRMAVCDNPPWFGKTEQAAAYAKALEKAATLGWTLEPVDFSPLFQLASLLYEGPWVAERYAAIKDFIEARESEMDPTVREIILKAKGFNAADLFASEYLRQDLTRQIQDRFGDFDAILVPTAPTFPTIEDLAREPIKENAYLGTYTNFVNFMDWTALSIPAGFRSDGLPFGITLISSTWDEPKLLSMAREWLSTGPRLLGATRIERLEARSSDAIAAGEPKTTRLVVVGAHLTGFPLNKDLTSRGATLEIATTTSPNYRFYSLNTGGTVKKPGLKRVPSGGSAIQVEVWSLPTTQLGSFLKTVPSPLGIGSVELADGSWALGFICEPYGLDGATDITSFGGWRAFVKSLIPDVPPVGTTSKVSGIRSVLIANRGEIAVRIIRTLHSLGLKAITIHSSADARSPHVRNADVSLPLEGTSVSETYLNGVQIIALAKKAGADAIIPGYGFLAENADFASAVEAEGLIWVGPTAEQMRQLGLKHLARDVAIRAGVPVVPGSKHLLKSAEEALDEAERIQYPVMLKSTAGGGGIGLKRCDDAASLVEAFESVQRLAQANFGDAGVFVEHFIEHARHIEVQIIGDGCGRVTSAGERDCSLQRRNQKVIEESPAIFVPPDVRRRMRKAAIDLGSAVKYRNVGTIEFIYDVDTSEFFFLEVNTRLQVEHPVTESVTGLDLVECMIRVASGNSRHIFVDKPDGFEVKGSSIEVRVYAESPLQNFRPSPGRLLDVSFPEGVRVDTWVEAGMEMSSSYDPLVAKIIATGEDRTAAIAKLADALQKTVITGVETNLEYARHIVASEMFRSGTFITTSLNSFAFDSSIVEVVDPGTLTAVQDFPGRKGLWHVGVPPSGPFDDYSFRLANRLVGNDSRAAGLECTIHGPSLLFHYDAVVAVTGAFAEVKIDNKPAQPNTPLTIQRGQKISIGAATSGYRSYLAVRGGIDVPEIFNSRSTFALGKVGGHNGRNLRSGDLLPVGSMVSTAPSADSGPAIPLPSDPANAHWSIGVVPGQHSAPEHFTEEGFSTLFVDEWTVHYNSNRIGIRLDGPKPQWARETGGEAGLHPSNIHDSPYSVGSVSFTGDEAVILTCDGPSLGGFVVFCVVASAEMWKLGQLRPGDKVKLQPITVDDALFLESALEKSIAELTPLAVDVAPLANSPTTPDSNPFLGDIGSAGRRISVRQAGDNAMLLEFGTEDVFSLRQSFQIFSFIARHKTHPIPDVLELSPGVRTLHVQYTPKTPPATVLSALRAHETSLGEAIPSSISSRTIHLPLAFDDSVSRAAVARYVATIRATAPWLPSNVDFLQRLNALDSPADVERIFLDATFLVLGLGDVFLGSPCAVPLDPRHRLFGTKYNPSRSFTPRGAVGIGGQYMCIYGMDSPGGYQLVGRTVPIWDDVTASAVASRGESKPWLFRLFDRISFYPVSEMDLDAAIDQGRMTDLVKIEEGSLDLEAYEAWLAANKADIDATRGLRAGAIRSAPFMEELLQPYNPPEAERRGGAFGEAEDSTPGERIKAQMPGRCWKCEVKAGDEVDVGDALVWIESNKMEIKIGSPIKGKVVKMLVVEGDIVGPYDDLLIVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y305</accession>
    <name>A0A1B7Y305_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154916.1">
        <property type="nucleotide sequence ID" value="XM_018305492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y305"/>
    <dbReference type="GeneID" id="28869599"/>
    <dbReference type="KEGG" id="chig:CH63R_10518"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10518"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="770" mass="84009" checksum="9DCD050B17CE1C82" modified="2016-11-02" version="1">MSMADTTPAHSPVGAASRTHKSCDACKSRKVRCPSTGPPGPCANCTRRKQECRFSVKKLAHRRNVAGQLLPTNYSPSSQRAPSPPNATAVLDLSTSDGQIKPEATETPSPKSPSHRIHELYVDRILARAQEPKDSDGKAQEDAMFVPRLRNRKVNELVGRISAIVNGRLRRADPATTTTRKTGQPGTVVYRGSANLYIRRKRSHSVTYTHTTLMFVPPECFCRQLTSPAGPVYFERVHPSLPFLDRASFESTVANPNFPSLLEHSKPWTCLYHAVLAIGSQHADGGTFEPGKGESWRLFSVSLGSFSDLLLLPDSLTTLQALTAMSLYALCLCGLSVEPVIMSEAARRAQMMSSHNFTGSAASAYQKAFWSMYIIEKITSFHIGRSSVRSPPPPDNNNDIPPGSSLLYAANRPGQSFVDCDISCPIPVIPDAAIAGFNPFLHLVRLSRLLSRAYTSLFSVGVSGNSSSYYMDVIDQLNVELEAWRASLPDNGFRPGGTVRAQAILEPMARSLAVVLHYLYYSLLLTLSRTMLVYLQTSDGSVAVAPEVAAKRSSNVKTTLNGSRFILELTSMIEVEPYTNTWVIAGIPITALFVLFDIVIHDPQLPDTASNLALLDMAAGHFSRIEFVSGGAVPGSLIAEFAKIARDYVNEIQQSEQRTTDAAKPPTEVSTTAAQEPAFELQDSQQAPQPDVMQMDLSDTMVRHPVMPGPLQSGFVDFSFYNGMDQVSPGAPMGTNVMGLFSYFLPDLDPMFYQGLTQDYDMLPNGGPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3D1</accession>
    <name>A0A1B7Y3D1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155055.1">
        <property type="nucleotide sequence ID" value="XM_018305631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3D1"/>
    <dbReference type="GeneID" id="28869738"/>
    <dbReference type="KEGG" id="chig:CH63R_10657"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10657"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601288" evidence="1">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="204" mass="21770" checksum="6F679EE12D999159" modified="2016-11-02" version="1">MRFAAAGLALWASVAVAIPSDKGYHYRSAEEMKDELLPLSEMSFTGPVTVGGPNVTLHGDASSIYDQILALNPEFDASAFGGAASVERGLEARQSTGNWNCNNGVTVERYYSQCANAINRLFTLGTSYCSVAPSTCARVSCSKSCSIYLCNNQFSQVNVYCQDIAIDMGIIVSKCGSDNGNGDTRARGSLHFTGHYTSLTQQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y426</accession>
    <name>A0A1B7Y426_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein fta7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155289.1">
        <property type="nucleotide sequence ID" value="XM_018305865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y426"/>
    <dbReference type="GeneID" id="28869972"/>
    <dbReference type="KEGG" id="chig:CH63R_10891"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10891"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="475" mass="52916" checksum="00AE51B89A10B8E6" modified="2016-11-02" version="1">MAPKKRGRKPKGKAVEVEEPTPEEEAQAEAEPAPEKKRGRKPKAAAEEGEKPSAEEESKAAKKKHRRPAARTEPEAPEARRRKDRQPSPAGEPATEKPTKKRRKRSSQTEEKPSKSPPETQRRRPGRPRISDGASSPHAPEEQPSKSRKSKKRPSGDEDAADSAPAKKRRRRTSDEIRQQQQQQQLLLQSSMDPPAARRPAPKHRHIAPRVRQIPRSIIEEKWTPLAPPTLAHVSSLLRLAERPVLQRLAANEKRRDQAASAIRLVTNRLSRKLSRGLPFPPAAAPSTGSGVGARKAADADGGRAEELNFERVIEGVAALERQLDPLLHAVELLKVEKERDERSLEADYDSLRTLEANARSEARNFKDNLRKTHVLVPEPKVAGAADSSRHGSVGEEHDFKFVPDENVTGTLFRDLEGNELRELAGQVSSHMESMRNNLQQIDGVLPQIVRSRAALQDVLFKHLDQPSYENVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4Q9</accession>
    <name>A0A1B7Y4Q9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_08467</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155464.1">
        <property type="nucleotide sequence ID" value="XM_018303441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4Q9"/>
    <dbReference type="GeneID" id="28867548"/>
    <dbReference type="KEGG" id="chig:CH63R_08467"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08467"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="890"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="894"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR06946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1099" mass="121722" checksum="9F24E352AE1202DE" modified="2016-11-02" version="1">MATDEVFDLLFLTDATASMRSYLQALNQSLPEIIRISSLTDAFSRVGVMAYRDYSTDSLTEWSGWHAASAREANENPDSISQAKLLDMAGKIRAESGWRNIDWPEAVKSGLAHAYSVMRPEAITIIVLYADAPPHLPGTDTKNRRREIDHLSNPDTFNGCGSLFTDWVSGAKTLRDGQKKARVFPLIQGAIADTVAPFTYLAHVTGGTCFQLANAHPDISTADAISQLTTAILLTWMGVAKQGASVSGQRRFARVCQYRNAQDLEQLKSEEDRAAEVFFPVDRHVEGPANANITYGHFTLDELPEAIEPRKTPLLDFSRRYRVDEGYRTLVASQLQSIIEADVATVAVNPVFGSLWRAACNDRDNPARDQLISSFGYHVDRIKDLNKRAQMKLWLEESYDYAAEVLEIIGTVPESQRFPCVFMDPTASFEATDDGGVSEEGREATGPASTTFTREELLEIGRSCDYRVLRRLGKVLTRLTYVNSEKELPVHIKAAAVDQVTRIPVALANPEHQRKFWKILLHLVLPGTMLAARPAALLAALALRMGIQPLRDAADQELLGFTDKWNNLDIPETWNASCLSLLLDADEDFERRVAEGVTPRPDPETRILLEGDRHLFKTLVDYKLLELNLNTTLQAKIGWCPEKSKVAVGPVAVCKGCRFPRSVTIMGNDGICGLCPQHDHCKCSVCKPADDADIRLCNNVSYDDTENTEATWVECFTPSCRAQYVVYNPETLNVRAKCYYCRHENSPKAESKTAPCVECTQCLNRVIWPKTYRSADFDVSTFKCYACATNRVTVVNHETSAKGLSNENGDAWLLRNEGSLIKDPFNGRSLFHTISQVPESQRAALTTDVEVIPSAQQQQPIKLTVRGKPVHNPADIVECLSGWVRSRRTESGVCSLCFSNVKKTDLRRACGRKGCHQQVCSGCSKDWYGLNTRGTLINAAALCCPFCRRRPTAKTVSPFGVSHIGDLNTAVADTEWIYGWCQDCGFARRYAERVCAAGAPEVSGWSCDGCKKGGKMQVRNCPGCGTPTEKMGGCGHITCTVPGCSAHWCFFCGENVGLGDIYAHMSSAHGGYWDTGGDEEDDRYENEEDEGGEMYDEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y588</accession>
    <name>A0A1B7Y588_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc knuckle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155680.1">
        <property type="nucleotide sequence ID" value="XM_018303657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y588"/>
    <dbReference type="GeneID" id="28867764"/>
    <dbReference type="KEGG" id="chig:CH63R_08683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08683"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000085">
        <property type="entry name" value="Zinc knuckle nucleic acid binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="15133" checksum="EF76841FBAA28603" modified="2016-11-02" version="1">MSRDCPEGPKDTKSCYRCGQAGHISRDCPQGGNVGGGAGPSSSECYKCGEVGHIARNCPKSGGGYGGGFGGGAGGYGGGAGGYGGASQKTCYSCGGYGHMSRDCTNGSKCYNCGENGHFSRDCPKESSGGEKICYKCQQPGHVQSQCPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y604</accession>
    <name>A0A1B7Y604_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155942.1">
        <property type="nucleotide sequence ID" value="XM_018303919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y604"/>
    <dbReference type="GeneID" id="28868026"/>
    <dbReference type="KEGG" id="chig:CH63R_08945"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08945"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="156" mass="17105" checksum="D641ACB6EF5719CB" modified="2016-11-02" version="1">MTFDDEKSWHCREEKGDLNGQATDLINSKACSMKRPGAGLIETEGPYTCSQRVSRTGKSLSRCVMRTNVNTYHDPTCHPAYVSQDTATSVVTRGSTGEQRPDTPSQSTPHRRIETLWGSIPGILPPGPHAATDEIVDSERLAILPAANFGQDFRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6T5</accession>
    <name>A0A1B7Y6T5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156225.1">
        <property type="nucleotide sequence ID" value="XM_018304202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6T5"/>
    <dbReference type="GeneID" id="28868309"/>
    <dbReference type="KEGG" id="chig:CH63R_09228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09228"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="301"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="675" mass="73911" checksum="BC0761B11CB13D03" modified="2016-11-02" version="1">MGGPTEKRPPADWDRGGHVVDRLAQMEQLVKELQDPKTSSGSHQTPSSSSQNPATVSSDAHPASVADDPAKPSPGTKPYYSGAESEATVGTVGKTTAPACFQLVTSPPPKHLRELIFPRSKGSCSLFSAEGIAKIDALVGDNRFSVAVQGLLQRIRRIAPPPNPDPLASSVTYPFPPNNVIMECMTDFFQTLNHDIKLLDEAEVRAAVQAYIYGRPPPGSGWRMALNVILLHTLRKRDWASPTGEYDKYLHNAMCLIPSAILQTPNPMAIGALLSLCSKRLTGHPPQKSSYFIFKAENHTSLSVLAVAVQHILLAGYHHANHPALPAADVLHRRRLFWQAYVLDHDLMLRIGKPPLIADDFLLALPDEFPADGYGVFFYPGDVTLNYFRQQVRLSRIQGRICSRLYFKQHTPSSSSWLEAEIAALDAELHEWRESIPAMIRPQPPSSGLVDADYSRMMSLSVLHFVYFQLVVAVHSAAFRTRALDGGGGDDDGDAESLRPSIAVCVNAARGAISLLNYHQLQHPFTIYLLYQVAWCVDILFVNILEHKTSPQSLQDLGLIRLVLSFFERYDADHQRVASYHIIRALYDVASSVTSNATTPLPALPPMMGTDALADSMPMLSMSASASDLDMAGWEEVSLGGHDWLSAGFLQMADWGLPDDSAAADAGTDGDLDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y703</accession>
    <name>A0A1B7Y703_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_09332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156329.1">
        <property type="nucleotide sequence ID" value="XM_018304306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y703"/>
    <dbReference type="GeneID" id="28868413"/>
    <dbReference type="KEGG" id="chig:CH63R_09332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09332"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="452" mass="50464" checksum="2631EDC85C62FB9C" modified="2016-11-02" version="1">MASSSSNVVGVHYRVGKKIGEGSFGVIFEGTNLLNNQQIAIKFEPRKSDAPQLRDEYRTYKILVGCPGIPNVYYFGQEGLHNILVIDLLGPSLEDLFDHCGRRFTIKTVVMVAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKAANVIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIKDLCEGFPDEFNKYLTYVRNLGFEDTPDYDYLRELFTQALKNTGEVEDGEYDWMKISKDSGKGWDAMKGHNPGYLHNPNARPGPSQMELHSGHRGGAANPNNPQNLTVGRLNAAQPPPPSPIKQMAKSRGQPNAPGALNAQRGSGVGGLRDMATPTGSTQAQFQNSNRNLPQNVPQQTPMNQQQAPPNGRPAEPQPTGFQKFMKVLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7F2</accession>
    <name>A0A1B7Y7F2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156356.1">
        <property type="nucleotide sequence ID" value="XM_018304333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7F2"/>
    <dbReference type="GeneID" id="28868440"/>
    <dbReference type="KEGG" id="chig:CH63R_09359"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09359"/>
    <dbReference type="OrthoDB" id="4845213at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="202" mass="22695" checksum="9CA3046EAD5CE692" modified="2016-11-02" version="1">MSTSSQSHVAAITQTVNALLLRTFALLQTPLSVLTLHRALNSADQALATASHFHRFDLEARAHLYRGHVLRAWGHWRAAHAAYVRAASARGLGFSDTDIRSLTGDCIEMIRFEDEREERLRRAHRAAKQGKEGTKVVRFSDEQRSLAVFQDHNDDNESTRSEASADEKYLILDSNGEIVGSRENLPDLRSVRGRSVCKMLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y865</accession>
    <name>A0A1B7Y865_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trichothecene C-8 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156715.1">
        <property type="nucleotide sequence ID" value="XM_018301937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y865"/>
    <dbReference type="GeneID" id="28866044"/>
    <dbReference type="KEGG" id="chig:CH63R_06962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06962"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="58448" checksum="0B331208DA875026" modified="2016-11-02" version="1">MDHRLTMHNETRVDSYLNDLVGDRFVVCFTTLVVTLLLSRILAKPVINLPELNPKKPKEILIQGRERFHNKLYKAYCDWGEVIVVSPEHIEELRSDMRLSFMVPANDDTHGYIPGFDPFQLDERLAKLVTKHLTKALTKLTAPISKEAAFALRSILTDSSAWHEMNPKEDLVRLVSQMSTRIFLGEEFCRNEAWINASGDYTLAAFEATDPVRMWPRLLRPVVHWFMPICWDLRLKLADARQTLEPYMASRNAIKAAALAKGEPCPFDDLVEWWESEYGPSNNHVINQLTLTIVAIHTTSDLLQQTMIDIAKNPELFAPLREEVVQVLGSQGLKKTALYNLKLMDSVFKESQRLKPVLLGIWRRQALADVELSDGYVIKKGQKVIGDSTHMWSSDYYTDAQKFDGYRFMRLREATGGEDSDSKTAHLVSTSSKHLGFGHGLHSCPGRFFAANEVKIALCHLLLKYDWKLSEDAKPDSNWTVFGMTIIPDPSIKLMVRRRQEEIDIDSLESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAY5</accession>
    <name>A0A1B7YAY5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_08028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157780.1">
        <property type="nucleotide sequence ID" value="XM_018303002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAY5"/>
    <dbReference type="GeneID" id="28867109"/>
    <dbReference type="KEGG" id="chig:CH63R_08028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08028"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR09263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="559" mass="61694" checksum="5E1EBE98019E15EB" modified="2016-11-02" version="1">MTNATDPLALAGVLDAQFSKHWPTATAGVIFVVFALLAQSWLAVDPLADVPVVGKGGRWARRKQYLQGQGNQLYIDGYKQFKDSIFRLTTSKSETLLNPRDSSQTPPADPFPPEKDTICVPPKYLPELKKAPDDVISFAKAIDEWRHAHLGPCRQGLVDPSFALASPRGSPLPLLQMHGANQLSTARLNASISDEVVESMRLELPQSTDWTEVNINAKLLRIIAMVSGRVFIGSELCRDERYIDASINYTVDLMTAVHVIALVPSFLRPIVATWLPTTKKLYRRIAEAESVFRPIVTARREAAAANRDDYREPDDMLQWILNAQTKFGQLSDRDLASAQLGISFAAIHTTTMTTTNAIYWLVAKPELIPMLRDDVQQALLESGGEFTSGALQNMKKLDSFLKEVMRASPLSAGSFTRKVLKSLTLPNGQTIPAGMNIETPAAGVNNDPEIFPDPEVFDALRFYRLREAKEHAASGAKAAEVVMQAQFVSVGTTHLTFGYGKHACPGRFFAVNEIKMIMANILCHYDVKLPDGETGRYENLVFGASSVPDPKKTILIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAZ3</accession>
    <name>A0A1B7YAZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157651.1">
        <property type="nucleotide sequence ID" value="XM_018302873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAZ3"/>
    <dbReference type="GeneID" id="28866980"/>
    <dbReference type="KEGG" id="chig:CH63R_07899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07899"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="156"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="579" mass="63976" checksum="D9D084AC8A0BB7D1" modified="2016-11-02" version="1">MYLLLQLQLRHFRRKSLATRPVIQSHTEQAQSPDSSYISHISPSPRSSSFCSLALALSGLGICWHHRVHGAIFNLAKSTVPLVHSEIGMAAQNLQNGAQPKYERTQTQPENPFAALIPEQQFAVIPKFTLESGVTLYNVPVAYTTRGKLSPNGDNAMVICHALTGSADVGDWWGPLLGGPGRAFDTSRFFIVCMNALGSPYGTASPVTAKDGDPSRGRYGPEFPLTTIRDDVNLHKLLLDDLGVKQVAAVIGGSLGGMFVLEWAYFGKEYIRCVVPIATSSRHSAWGISWGEAQRQSIYADPKYDDGYYSFDDPPSTGLGAARMSALLTYRSRNSFESRFGRNIPDPSRRQTIRERPRPSTPSEAHFHIHNDGHNVKRGSLSRQNSQGSASRTPVESTTAEAVTEALDPQFHGPQTESLTGGDKLPTSTYFSAQSYLRYQGQKFVKRFDSNCYIAMTRKLDTHDVSRDRAATIAEALALIEQPTLVLGIESDGLFTFAEQEEIAEHVKDARLERIDSPEGHDAFLLQFEQVNRYVLDFLKQTLPDIMDKKGEEVEELGVGQLTKSSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB25</accession>
    <name>A0A1B7YB25_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157682.1">
        <property type="nucleotide sequence ID" value="XM_018302904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB25"/>
    <dbReference type="GeneID" id="28867011"/>
    <dbReference type="KEGG" id="chig:CH63R_07930"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07930"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601487" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="124" mass="13503" checksum="24197A4ADC4AE3F5" modified="2016-11-02" version="1">MLKSYVTALLFTLMTAAPAAAQCKNAKVTVSCYPYGGTTGGYMCNEAQAECAAGQRTELFQKLRFDCLRKDENGKPAPTCLYDLIGLECIWTGTNVVMKRLVYCKVKNRGVLGLVGKMTTLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBP5</accession>
    <name>A0A1B7YBP5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158009.1">
        <property type="nucleotide sequence ID" value="XM_018303231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBP5"/>
    <dbReference type="GeneID" id="28867338"/>
    <dbReference type="KEGG" id="chig:CH63R_08257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08257"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="139" mass="13799" checksum="A635DCB884CFEE55" modified="2016-11-02" version="1">MAASNPATSTAPPSFLPAGPTPDPAVVDVARPVVAVAAVVTFVVASTADVAVVVGTLGLKVLEAVAVSSSSVTTVVFTAVALILDGDGDDPPSVVVDGRLAVLRGRLDVVGAVAVAPPALVVPLIRHWPFPAHVCPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBQ3</accession>
    <name>A0A1B7YBQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABA4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_08306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158058.1">
        <property type="nucleotide sequence ID" value="XM_018303280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBQ3"/>
    <dbReference type="GeneID" id="28867387"/>
    <dbReference type="KEGG" id="chig:CH63R_08306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08306"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="210" mass="22024" checksum="EEEEFB562E9E649A" modified="2016-11-02" version="1">MYPTGQFNGKVIAITGAASGIGLETALILAGRGATLSLADIHSEGLQQLQARLLSDHNVQVLITTLDVRNVEDVEAWVQQTVSRYGRLDGVANLAGVIPKSLGQRGVSEQDLDEWDRVLSVNLTGLMHCLRAELKAISDNGSVVTASSIAGSTGRRNNASHTASKHGVLGLTRTAAKEVGARGVRVNAICPPPKMGSVSESGRVTPPIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBY7</accession>
    <name>A0A1B7YBY7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nudix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158076.1">
        <property type="nucleotide sequence ID" value="XM_018303298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBY7"/>
    <dbReference type="GeneID" id="28867405"/>
    <dbReference type="KEGG" id="chig:CH63R_08324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08324"/>
    <dbReference type="OrthoDB" id="4808081at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="346" mass="38717" checksum="59952891B97313D1" modified="2016-11-02" version="1">MSNSIEQYQIGARISFHSRRRQLACTTDTADYGHRACCPLNQADFAEFFQGTYSIDTHHESMAAVKSAFSSLRSLFFFAFSFLCMVLLPRDTSDGAPTGNSVHCYSSQQGYLNLYPFATGKMDRMEPSSTVDFARRGKMAAKQGCVNWDPLATFRSVILTHEFQTHRPGDPNLHQHGADNVTKRGNGPASLDVFTDGYENGEEPVVRARIDTMGRKITVSQAWNERDKTDKRLHLNEILEALWEIGGMELSQLRSIEFTMVVNKPTLAAINNIRKRRGLTKNKAFRVKEAATGPMAADWTALFKSPLGKAARRMANEGGNLVDVFDVRGEVLTPVVEIEYLTVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCK8</accession>
    <name>A0A1B7YCK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158171.1">
        <property type="nucleotide sequence ID" value="XM_018303393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCK8"/>
    <dbReference type="GeneID" id="28867500"/>
    <dbReference type="KEGG" id="chig:CH63R_08419"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08419"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="745" mass="84069" checksum="D4BE4B4BF610AD8C" modified="2016-11-02" version="1">MPVDNHRQRPLLPRTAQPPPLEPNATNRDDGNSNGRKRRRSYAPKACDFCRDKKTACDGHLERSQCLRRGLKCEYRVVTDTILKAIPVGFQLVDKQQSLSNADAADLLEILKRVPEDEALEGLRLLRTGNDPALISSALRGYDAGLSLAALNRASLPPIQSSLEFELMMRHPVAYPTWQPFQPSKLDLDFLLLPREVVWNESQSGPTEYVGSLLRSLLTSNPGFRTADSFSPYAHRPRGDSSNSTGRVGPRNPSTVYDNRLLSVDISQWTDVPITNELSLAVLQLYLETDHPMMPLIDVDLLLDGLLGKNEFCSRILVSGLFAWACQGYAAFEPEATVVGYSFYEEAKGLWRRSKEARVEDNICTVAAMHYLLMTSVSLGAGAQYVEFLDDLLDMSKRLELFNVGPSHDSRLDLENSANYRKAKSQIAWVLFACLTFFSTQLHQRLIEHPPRGPLPGDSIHAARDADTIPKEDKRRVYNEVLLTEHCRLSQIVHDVVKIMYGPKQTPCAKAVSLAFAEETYGRLLMWADSLPLELAQGDHCTHHAVIAISSIYHHLAIIDLFRSLLQHNGTPWQRLSTFESEDSTPDAVYAASVKQLQRTVLFYRYNHPESAYSFFWHSALLYLANAMLTEAKVPGHAPDWQFYLRLCIACYQTLYTGFRLAKGITLSLLSMALEKDAMDIPQTRTIRRDLELLGKHHLIPDQVPVYWVVDLDLALTDPFAAHAENLVQRFQKLHLRETSETNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDX9</accession>
    <name>A0A1B7YDX9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LSM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158525.1">
        <property type="nucleotide sequence ID" value="XM_018300675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDX9"/>
    <dbReference type="GeneID" id="28864782"/>
    <dbReference type="KEGG" id="chig:CH63R_05700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05700"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="41"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="146" mass="16443" checksum="DEA7CC9143CCC8BF" modified="2016-11-02" version="1">MSVQCVPRCAVIFLRTTQRYQKSNAHHCDQGAAMEKEEGRGFLTSLLNKNLRILVTDGRMFLGQFKCTDPDRNVVLAHAYEYRQPSAQQRAELSRQTTDGSGTVTIDMTSRYLGLVVVPGQYIVKIEVEEFASQIRGQNPYADVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDY8</accession>
    <name>A0A1B7YDY8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158535.1">
        <property type="nucleotide sequence ID" value="XM_018300685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDY8"/>
    <dbReference type="GeneID" id="28864792"/>
    <dbReference type="KEGG" id="chig:CH63R_05710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05710"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="121" mass="13295" checksum="7E324A894CE73517" modified="2016-11-02" version="1">MDSLTRRIRIATLQYCPYLITHQIGAYRSTQNAFNDVTSRANMLSFGPCRHRSGQDLRSGYDGLSQLSNTARMPRLVLADHNASYSLNLTAPQALAQPGMGQHGKFLMGSDPELIASPCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEX8</accession>
    <name>A0A1B7YEX8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158997.1">
        <property type="nucleotide sequence ID" value="XM_018301147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEX8"/>
    <dbReference type="GeneID" id="28865254"/>
    <dbReference type="KEGG" id="chig:CH63R_06172"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06172"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="155"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="58325" checksum="E7AEB545B2D9AB19" modified="2016-11-02" version="1">MPLFDTLDASLVDSPFRGPKFVPLSSLKTIITKASVEQELSSITRLRNPQLSRNVVQNARKVFSILVFIDKASAIKELYRDGLTDDQLPLSSRKDDAGRITPFTHHGKKTFASFGSWKTVSIKSFLDKQWLLLSPVFDKTGRHFDLNPACALPMFPDTREVATGPYNAVHQGWIHPAHQRVSKNCGEHGLKVALKEFRGEYNSAKSNFEKEWENLSHIQQHNHPHLIKHIATWQAGNKFFVMFEWADGGSLWDFWERENPGAPSQEVILWSLRQIRGLVSALEALHSLNCRHGDLKPENILHFKDRGDKHESSGGRGILVMADVGVSRVHKQMTHLRIGPTTTRATTISYQAPETDTDPKVARSRAYDAWSIGCILLEHIVWLLYGLQGIEGFRKRRESKSFDGTYGSANFYSLTISHLERRAEIHHAVEDAMDALQRDPRCQVGTALGDLLKLIREGLLKIDPQDRFKALEIQDAVERIVRDARPDSLYLLNTSNRPSPVPSIFRYVYVSPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGE5</accession>
    <name>A0A1B7YGE5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCCL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159471.1">
        <property type="nucleotide sequence ID" value="XM_018301621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGE5"/>
    <dbReference type="GeneID" id="28865728"/>
    <dbReference type="KEGG" id="chig:CH63R_06646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06646"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF8">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="663" mass="73996" checksum="D3EEA57E683D2190" modified="2016-11-02" version="1">MADGRRHEHEPLLTAMERQQADEPATTRANPTEHPDAPLADTARRELEVDDDSSSQSTPRFMQDDGSWKRWRWVPYPVRRIVKATAKWSKGPPNPRNYKIKPILPQIQEFPLVLIDRYLPLFKHRVGLVFLYVAVWIVTFALVKRSETFATEVEGWGAPQQIGCGATYWGRGNNCGLNGADCRPFNGSGFPFRCSANCAGYMVLNPRAVGDQEIVYQSLVIGGPTDNSSTPIYRGDSFLCSAAIHAGVVSNENGGCGVVRLVGRHEGFPSSERNDIESISFDSYFPLSFTFEPGIQCKARDLRWNLLAISLVFTTILSLVTASPVLFFFSIFTGVFWHVGLASDPPNHYSVADLVSNIIGKFLPAMFCAWVMYDKMGVRRTLTGLTAQVEKTVLWLGGCWVGALSNYTFRWIPIQRLNAHDLNQQPGAKAALAAIIIVLVVIIVQQVWYFRQEGRLLKYLKLYLLFLGGIVVCLVLPDLSLRIHHYILALLLLPGTSMQTRPSLLYQGLLVGLFINGIARWGFDAVLQTPAALQGDAQHGSVLPSILPPIVDLGQAAWNINFTWNNPPVGARYDGISVLVNDVERFRSYFDDGPVPAKSFVWTRESDLGLNEYFRFGFMEGSTSYDYTKAGIWNAEGKWIDMKPGPSMVRARSLGDEDDFVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ23</accession>
    <name>A0A1B7YJ23_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_04377</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160598.1">
        <property type="nucleotide sequence ID" value="XM_018299352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ23"/>
    <dbReference type="GeneID" id="28863459"/>
    <dbReference type="KEGG" id="chig:CH63R_04377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04377"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="248"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="364"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="755" mass="82721" checksum="F29BB2D61C8D1530" modified="2016-11-02" version="1">MHAAKMATSSSLPELPPNYQKALELIDEAHRQDPRPSAVESVPFELDYAQKMTRWLAVRCPTAPPVLQLACRAQHFRRWEIPRNTYPMTRPGYLTWRAKLKSQAAAQVAELISSSPGIQPELAREDVDRVAALIRKENLSADEETQVLEDVACLVFLDDQFDAFESKDEIDEDKIIGILRKTWAKMSEPGRALALKMDHSERAKSLIGKALAGTGIRRGKPSYKRRGPPKTSLPTPRRRRPTSNVMPPPTLHPAEVSRHNRLDDLWLVIDGRVYDFSAFVREHPGGIAVILQCAGKDATDVYSEVHGPNLVRSTLPPDCHKGVLAPGAVSAKPRQHSFQQQQQRKPQETMAGARRAIESLPSKPPLDTLISAHDFEQAASASLSPKAWAFVSSAATDLHTKARNASAYSLIGLRPRVLVDVAAVSTSTTMLGHPMRSPVFCPPTAMARLVHPDGEKELARACRSAGVPQCVSVSASFPLDEILAAQAAHQPATPYDVPVFFQLYVDKDRANSERLLRSAQAQGVKALFLTVDAPIPGKREADERVRSDESLGSPISGARAVNDAKGGALGRIMGSYIDASVNWSDIAWLRRTVPGLPIVLKGVQTWMDAERAVEAGVEAIVLSNHGGRSLDTSPATVTVLLELQKNCPHVFDRLEVYVDGGVSRGTDIFKALCLGAKAVGVGRGLLYGLNYGAEGVERYIEILRDELETTMKMCGVTSLDQVHPGFLNTLAVDHLIPGRPHNPNTPWRRDRHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ94</accession>
    <name>A0A1B7YJ94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160666.1">
        <property type="nucleotide sequence ID" value="XM_018299420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ94"/>
    <dbReference type="GeneID" id="28863527"/>
    <dbReference type="KEGG" id="chig:CH63R_04445"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04445"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="262" mass="28692" checksum="0318EF2A938EE5C1" modified="2016-11-02" version="1">MSATSSFPPLTHHSPPRRLRWTRRQLVASFGAYTFPIVLDGISAAQSHNTTRHPLRRQVEELGHMARLPHAIGWQPGVVHQHQAPDESRYATPLNEAPASCRRLQAQKTGDIGSAKPERAHGTPLALEDPTSSQLSFQDCRDCADIDPGKKSAPALSLGAQSHLALAAHFCPALIVASSKIIIEGRQNARESADPPGSIQRNTPQSSNQQQRQQLADWTLWTANKQTNLFGIDDDSWPLGRATLQCSRVYCSGGGGWWMNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLL7</accession>
    <name>A0A1B7YLL7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_05084</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161305.1">
        <property type="nucleotide sequence ID" value="XM_018300059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLL7"/>
    <dbReference type="GeneID" id="28864166"/>
    <dbReference type="KEGG" id="chig:CH63R_05084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05084"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="435"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="678"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1021"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117736" checksum="AA308F6D87D8E085" modified="2016-11-02" version="1">MSSENAQSVKVLDELFQKLTISKEAADVKEASSALASFINGRIEDQDVPTKSIEAVRKLFNNKKDAGAREKAAVAITSIAQHAEVSAHVEPFLVALLPDVLAASGDKITAVKNAANQAALAIAEAINPNAVKGLFEPVKKSLLEAQKWQEKMAALDVLETVVRTAPAQVGYRVPDLIPVVSESMWDTKKEVKERAYKTMEQICQLIVNRDIERFIPELIKCIAKPENVPETVHLLGATTFVTEVQEPTLALMVPLLDRGLAERETAIKRKAAVIVDNMCKLVDDPNIVAPFLPKMMPGLQKNYDNLADPEAREKTKQALDTLTRVGNVVDGKIPEVRHDSDLDVVLPKLKESIPAKYKAKADKLEIILQYAANIAGQLIDEKEIESIVWVEALKPYIAVVVGDEDAQKVVDDFRKRASPGAAEEAEVDPDDEEGEDLCNCTFSLAYGAKILLNQTHLRLKRGQRYGLCGPNGSGKSTLMRAINNEQVEGFPKQSEVKTVFVEHDLDSADTEMTTIEWTMKKLQDAGVETSQADVEAKLNEFGFTENMVKGEISALSGGWKMKLALCRAVFEAPDILLLDEPTNHLDVKNVKWLEEYLQNSPCTSIIVSHDSAFLDNVCQHIVHYERFKLKRYRGNLKEFVKKNPAAKSYYELSDSEMEFTFPEPGFLEGVKTKAKAILRATRMTFQYPGTSKPQIQDISFQCSLGSRIAVIGPNGAGKSTLINVLTGELIPTQGEIYQHENIRIAYIKQHAFAHIDNHLDKTPSEYIQWRFQTGEDRETMDRANKIITDADEEAMNKIFKIEGTQRRIIGINSRRKFKNSYEYECSFAIGDNVGQKNERWTPMMSADNVWLPRNELLASHQKMVADVDMKEALASGQFRPLVRKEIETHCANFGLDAELVSHSRMRGLSGGQRVKVVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKALKKFEGGVIIITHSAEFTKNITEEVWAVMDGKMTPSGHNWVQGQGAGPRLKGDDADEEEKFDAMGNKIVSTKKKVKLSSSELRKKKKDRMARRKRGEEVFSDEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM28</accession>
    <name>A0A1B7YM28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161620.1">
        <property type="nucleotide sequence ID" value="XM_018296804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM28"/>
    <dbReference type="GeneID" id="28860911"/>
    <dbReference type="KEGG" id="chig:CH63R_01829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01829"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="245" mass="26221" checksum="7EED7128D7D21C16" modified="2016-11-02" version="1">MSEIRTIAFFGASGGCGLAALKHALAADWTCIALCRNPSKLTDVLPSAQYPKLIVRQGNAHDAAEVGACLVDPADPARLVDAVSSSIGSPLDVARMTVEDPDVCKNGAAALLAALETLRARGVRGRPRLVIVSTTGISEHGRDVPLLQVPMYHILLRVPHADKRAAERVVTASCEDFTFVRPAFLSDGAVPDRAVRVGVEDPEKGVESKAVGYGISREDVGRWIFENVLRDGGRVYVRKAVTITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMP6</accession>
    <name>A0A1B7YMP6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BCL5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161711.1">
        <property type="nucleotide sequence ID" value="XM_018296895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMP6"/>
    <dbReference type="GeneID" id="28861002"/>
    <dbReference type="KEGG" id="chig:CH63R_01920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01920"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="489" mass="54564" checksum="CF602A9670F56AA1" modified="2016-11-02" version="1">MFGLFSGQRKAPQRVSTDRVVPVGFFDDTVIFRTFVLYTLFVFDDVLDAAKLRGSLESVVSRPGWDKLGARLRRNDRGELEHHIPQKFSRDRPAIGYDHVDLNDVAIEDHPSASRIPRPPSDGRPAVVGDPNELDDLIHGPRIPKGLDDYLYEDQPELGLRIVSFKNSTVVVLHWIHLAIDAVGMRSLMQAWMLALQGRHEAIPKPLAAEQYALEDVGKAPKETHVLADRLLSMPGLISWVVRNAYGLAFCKKEHRMVCMPAAYLEKLREKALVELAAAAEAASEGRKDSPFVSDGDVLVAWAARLSMSNLPKDSERLVAIQQAYQWRPVLKDLIPPERPFLSNCVGFLVTLIPAKDLLQKPLSYAASQVRRSVKEQGSREQVEAYAELIRRDPGNRAPPFLGASSMQLIGFSNWQQGNVYGLDLSSAAVGPRDAPLMPSYVQNVQGPYNFTDGIIIVGKDAGGNYWMSGYRVQGLWELMEREMAKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNE4</accession>
    <name>A0A1B7YNE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PKSN polyketide synthase for alternapyrone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161971.1">
        <property type="nucleotide sequence ID" value="XM_018297155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNE4"/>
    <dbReference type="GeneID" id="28861262"/>
    <dbReference type="KEGG" id="chig:CH63R_02180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02180"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="15"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="426" mass="45402" checksum="FFAF8C8ECC72A038" modified="2016-11-02" version="1">MGSLADRGQVCCDPTTPVAIVGMGLRGPGEANNLAGFFKLLSEAQETRTAGQNGRWNHDAFYHPDAARKGSSNVKAGHYIIDDLSLFDASLFRMTESEAAADYTDLLQRDPDSMPYYQATSSGYSRAIISNRLSHFFDLRGPSVTVDTACYGGLAALHLACQSIRSGETTQAIFGGSSLILHPHQFDSLSAMRPDGRSYSFDDRAEGYARGEGDGGTPGISFPSRNAQVSLIKETYARAGLDPKDTSYVEAHGTGTGAGDPIETSAIAEAMTQSRDLDAEPLWIGSVKANIGHLKAASGIASVVKCVLMLENKVIFPNRNLANVNPRVDLEGWRLKIPISFQPWTIKAGGVHRVSVNSFGFGGTNVHAILERAEEFLANSHDGAIGDKHISSMGSRCSISHGLAHEGNGLQRALPTALQPGGADLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPH7</accession>
    <name>A0A1B7YPH7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">CH63R_02578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162369.1">
        <property type="nucleotide sequence ID" value="XM_018297553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861660"/>
    <dbReference type="KEGG" id="chig:CH63R_02578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02578"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="330"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1254"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1301"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1318" mass="145346" checksum="38BC22B4A92803E7" modified="2016-11-02" version="1">MSQSDQPNGKDHAAKESTPPVEAPIESQAEGNEVDQGLEALITLTIKLPHEPGQMQITVSPQEQVHEVRQSIIDLPVAFQYTCFHLEHHGERINDFLPISEIEGLTEDPEVKLVEDPYTEKEARIHLVRIRELIGAAGDRTDAVQGILPGLSLLDTVVPPLEEQANGEQPQVVKEAKEDYTFDAPVPVSTLLPPVEEEEAPKTIKSISLSAWNPPPVHLKQRGHLLYLVATTNEGEQHQITAHVGGFFVNKSSNAKFDPFPRPAPKGASAHSLLGLLEKVSLSFSASFVKLQDYNNRKDPLATFQITNAIPAAPWIVPSSSSPLCAHSPDSTRSQETYLIAGADNTDTLRDWNEEFQSARELPKDTVQDRVFRERLMSKLFADYNDAATRGAVLVARGEIPPLNPTECKDAQIFVYNNVFFSFGADGVGTFTSEGGDEAARVATGKDVAGVRLVNQLDIDGLFTPATVVVDYLGKRIVGQSIVPGIFKQREPGENQIDYGAVDGKEVVASDERFASVFAKLSQALKVKKHAVWDKDGKRVDLEASVETKGLLGTDARKYVLDLYRVTPLDIDWLEEEGEAEYPHRMAVLRPELIDSYGRKKMKAWVDEELARRGQTAKDAAKDVAKDETLAEPKKPKQVAAKDEESDDSDDSDDSEASESESESESEDGSEPNKKAVKTETSEEPKEVETSKESKDSKDHIDLSKFSFSLNPDVFSGQTPQTDAEKAEMEQDEKDVRLATKYLREQVIPDLIRELTDCDISFPMDGQSLGRLLHKRGINIRYTGKVAALAEDPRLQCLKDICVQDMVARSFKHVAANYLRHLPAPFSSSCISHLLNCLLGYKLNPKPSAEIDLDLKSLYSDADLSFQQVTPESIRANIAEEALKRFRYRLDPEWYTKVKPLQLLREISLKLGYQLQTKEYNFTDKPVAQAAPAAASANNGTPATNGQVNGEGGKKKKNRKVAAKDAIPVSSGPLSPATTFTSDDIVNVVPIVKHSCPRSALAEEALEAGRISIMQNQRKLGQELLLESLSLHEQIYGILHPEVARVYNTLSMLYYQLDEKEAAIELARKAIVVSERTVGVDSAETLLNYLNLSLFLHQAGDSTGALTFAKHALKLWKIIYGADHPDSITTINNGAVMLQHLKAYHESRLWFEESLRICETVFGKNSINAATLLFQLAQALALDQDSKGAVNRMRESYNIFLNDLGPEDKNTKEAESWLEQLTQNAVSIAKHAKDAQARRLRAGIHFTPKGAPYQASSTAPSVSSGPANVGSQLGGSSQMDSRSIDELIKFIEGTDQQTKTPKGRVSRGNPKRRGKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPW0</accession>
    <name>A0A1B7YPW0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_02789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162580.1">
        <property type="nucleotide sequence ID" value="XM_018297764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPW0"/>
    <dbReference type="GeneID" id="28861871"/>
    <dbReference type="KEGG" id="chig:CH63R_02789"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02789"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="300"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="814" mass="90186" checksum="43AB1A36B882B08E" modified="2016-11-02" version="1">MAKNMQLRSYSETRFDHRVADGYPFSNPTVDLSVSWDASGKNLLIYRPREQVVSKIHQFAKTGQQAPEPQAVRWKPDGEFMHSIKAMLMEIDPMTGQFLAVGWSDGYVRLMGLENNKAAHHIRVCGDDTTPPSITHIGWSRNIVGKQQTHFQETTSQPWRKLLSEGLELPGGAAPLDFPRELTFLEVDSALPKISPLPSSSAGAGEDGLVFTLRTGIEFLFQPFKTEDSDQVFVMVVGTSDGRLHLSIYDSFVIGDFRYTLPSSMYMPGVLQLVQHASHPEVSTHTLLLKSSADDDRALYLVPMDLPFIPSSPINISLLASKLTTLQKLLRYVKQTQLHIQVEYKNTRELPSRFLRSVEGDLEQMAHGPTNIVQALFHTVVTGHAYEPVREWLVDNLAERGHKRWDKAVVSGLENMRGLVHENLLPALERCAIILSRLRGLAQFYDSRDDIGFSVAQITRAIDVVSCLTLVGHRILLNIMEELDLFNAFSTWIRFQIDRLAAPSSASEELTEKEATMENSKVLVYVQNYLMASPMAAFLDEVTKEDYSANWERAEGGTSMLAELDTQLQRCEEGQTYLKAFPNVSFLVDYLSARAGGVFKDIAEAQKRSVRFGQPTKIALGRTIALVDSTMCSETREGECDGLTFTAVTEESRDQDVFVFRTFIHIINGISSNVVTTVAALSVDSGKIIDSKFLDSNTLILLVSKQDKSVEVVTVPVQSPNMNYVPLQEGSLPAATALSQQLQGEYTTATIPKDTSFTPVHLEVQKASSARGDVPARVCLLGANRTAYKVFSLGAGPDDTRQPSPAAAAVTRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ24</accession>
    <name>A0A1B7YQ24_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162662.1">
        <property type="nucleotide sequence ID" value="XM_018297846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ24"/>
    <dbReference type="GeneID" id="28861953"/>
    <dbReference type="KEGG" id="chig:CH63R_02871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02871"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="253" mass="27442" checksum="CB6A8F73D7B017FE" modified="2016-11-02" version="1">MMQSVHTWPPFLVSPLAHAEAHDVWSSLLRAFIEPPIPFTPPDDRDYPGGLSIHMAHRQGRGPRCGGSNGVACGALNPRALGCLPPHELQTVQDRLGSGPRGPLALAPPQHHLLEHCEQLAARERVGESEQGITLLNPSWKSLGVLAPSAWALSSWPWITSSLGANGLIGGAKTTAIFPNFITPPSFHSYYPNPSAVRSWAMLGRTAAGGRGDRNADAMLMLQVPTYWPTDLETRSQHSERSAIFPETFEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQQ2</accession>
    <name>A0A1B7YQQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162860.1">
        <property type="nucleotide sequence ID" value="XM_018298044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQQ2"/>
    <dbReference type="GeneID" id="28862151"/>
    <dbReference type="KEGG" id="chig:CH63R_03069"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03069"/>
    <dbReference type="OrthoDB" id="4850990at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="13295" checksum="76E7BF2C85BC20CE" modified="2016-11-02" version="1">MTKHRNRLSRLKRTIRMLRGLPMLSMNNIGAVTQRLQGVIMGDAIEALPDSGSEPNLLSLDYVVRRDMRELINTNNILIIQFANGTVQKTMSSMWPNWAYASSTGDDADDEWSEHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRR6</accession>
    <name>A0A1B7YRR6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome assembly protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163257.1">
        <property type="nucleotide sequence ID" value="XM_018298441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRR6"/>
    <dbReference type="GeneID" id="28862548"/>
    <dbReference type="KEGG" id="chig:CH63R_03466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03466"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="389" mass="40813" checksum="9E952A0769AD62A9" modified="2016-11-02" version="1">MSAYRNGSSNGLPGDDQMPSYEEAIAEGANPTSARPPSLSGSIPSLNLHNGTLPPSMLRLRSLGRTLGQNGPVTALIFSPKGYVASSLDNAGTALPSNTKLWDFLSKPPPGVAAGPQLVPSDIHNDAPVVVFSPDSKLVAVAERDIGSKREWRLKLRMGEEGRSVRCILNGVAHPAVFSGDGQMLAATDPSGVVVVFEAATSPRGMPPTKKVAGVVNHAPTTHVLFMPNGTDLVTLSMDGTVRVAEARTGKTLRRMEVDGAAMAGSGGTGARALGVSPDGRVVVSVWSRAVYVWEHEAGRVSSWELNKVRSNEGWPLAVSPDCRFLACRTDDGVDISDVYSGHVLAEVRTAAGIDGLVTAAAFSADGRFMAVGRYSGVVEMWKLAPFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRT1</accession>
    <name>A0A1B7YRT1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SCS3</name>
        <name evidence="6" type="synonym">FIT2B</name>
        <name evidence="13" type="ORF">CH63R_03462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163253.1">
        <property type="nucleotide sequence ID" value="XM_018298437.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862544"/>
    <dbReference type="KEGG" id="chig:CH63R_03462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03462"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601897" description="Acyl-coenzyme A diphosphatase SCS3" evidence="9">
        <location>
            <begin position="25"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="11">
        <location>
            <begin position="419"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="12">
        <location>
            <begin position="1283"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="10">
        <location>
            <begin position="1471"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="977"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1338"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="1160"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1606" mass="172941" checksum="425CA1377092CA19" modified="2016-11-02" version="1">MMGLSSVLTTTLLALRLFSLDALAAPTPDPVPQAATPGAAAGFWVSTIERRGTSAFGDANYKIYRNVKDYGAKGDGSSDDTVAIQAAMDDGNRCGFGCDSQTTTPALVYFPTGTYVVSKPIVMKYYTHMVGDATALPTIKAAASFTGMAVIDANPYDNQGNNAHTNQNNFWKLVRNFNIDLTGMPFTSGAGIHWQVAQATSLQNIVFNMRTDGGEANVQQGIFIDNGSGGFMTDLTFNGGKYGAFMGSQQFTTRNLTFNNCKTAVYMNWNWLWTFQDVKINNCGVGIDMSNGGGASQTVGSVLLLDSVISNTPVGILTAYSPASSATNGSLILDNVDMSANVPAAVQMLDTKATILPGNQKIASFIQGKTYTGAAAGSGKAVQAAQDAVVKPAVLLASDGKVVTRSKPQYEKVPASSFLSAKANGCKGDGKSDDTAAIQALFNKAGPNDIVYFDHGAYIISDTVEVPKDIKITGEVWPLLMANGAAFKDQANPKVVFRVGKPGDVGTFEMSDLIIQTQGPQAGAILMEYNIAGSTPGAAGLWDVHFRIGGSAGTQLQSDKCAKNPNVTAPANPECIGAYMLTHMTAESSGYFENTWWWVADHELDLPDRKAQINIYNGRGVLCEATKGTWFWGTASEHNVLYNYQFNKASNVYMAHIQTETAYFQGNPDAKTPFTVNQAILDPNFDTFCAGQGNRCARTWGVRAIDSKDILIYGAGLYSFFDNYDQVCVGQNNCQDHMVSLENSDVKFFGLSTKAAVNMVTVNGKSAALDSAVPLGELLRLLRSGGALGPRPIPGPRAVLGEAPVRYLAAPEHAGAVSPGFVAGEDGVRGRLRLRPEADDREPPPCYSRIGVAIIRHPSHLRGPCVATGSLLDCDVLPRCVLSHIPYVPFQADSSRIGNVILSALSISSKLRPSSTHPAANLNIVVACDPLPSWPSFALDAITHTLRPPKRLTMDTPPAPSMRSKTRRALDELNGATTSPPSSSPRTTRNSPYLPTPTETIVLASFPVILFFGTVFSLLSPDVRASHYDAAAQAHSQSTAPSYFARKSNLFNIVFVKRGWFWITAAFFAFVLTHPATKNITTRVQATLRWALVTTWWFFVTQWFFGPAIIDRGFRWTGGKCELVEEKVEMGEGDAKEVFTAVACKASGGRWSGGHDISGHVFLLVLGTGFLLSEVGWVVMRWRGSSREERSVVMTDGAIKTATVESQGLRGEPVPGDALGLGGKFAAAIIGLSSWMLLMTAIYFHTWFEKVTGLVTAFVALRIVPTSNHSDLVLHEDMSPIKAPANLPELVKAAFAKARSNGDLTYYATQATVLDANSIPFQLRFSPALANKPAAPRPKPDEPHKPFDPFESPEKGPLFIADLPESSHNLVLNKFAVVPEHFILATKAFKQQNHLLEPDDLAATYACIEAYRRYHGDGELYAFFNSGPHSGASQPHRHIQLLPVARMKDGLQDDSRWDVLAKQLGSFDVPGLPFATFADRIHRDMTPEELHAIYLSLFKSAVEAVEAHIGAVDDPGNDDASISYNLAMTSDRLVVLPRLAEGAAICQDGTPVGKLSLNGTVLAGTALVKNEIEWNALKAEANGTIQLLQVLSKIGVPADAYHSRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS40</accession>
    <name>A0A1B7YS40_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163289.1">
        <property type="nucleotide sequence ID" value="XM_018298473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS40"/>
    <dbReference type="GeneID" id="28862580"/>
    <dbReference type="KEGG" id="chig:CH63R_03498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03498"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="73" mass="8169" checksum="9E820CA33B6AAC37" modified="2016-11-02" version="1">MLRMFYNMSGLGGLLLVVIVLMALVFAASRFDFILTSGKDKDGDYGGEEDSTYAFYASKRRRASSVKRVTFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTJ8</accession>
    <name>A0A1B7YTJ8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="11">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_00537</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163874.1">
        <property type="nucleotide sequence ID" value="XM_018295512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTJ8"/>
    <dbReference type="GeneID" id="28859619"/>
    <dbReference type="KEGG" id="chig:CH63R_00537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00537"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="12">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR15357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="739" mass="82795" checksum="22774D467C969723" modified="2016-11-02" version="1">MNAQELTHYLADAPPSVVRLEIEKHFEPLTDKQKRYAHFISKPLEPDAPSFYGAWELNETPRASFAGSRIVLRQLSPESEPIYDFIIALHKSSGGDWNSLAKKAGVDETQLSYFLEYAAQFLGNNGNYKSFGDAKFIPRAEEKTFAAFAATSPKAERFYKATNGAIFSSDKQALMHLGYPDKGHMTTYYPDSPHITQNEIEAVSAWMEKKGLLPENTRLRKTKEGSFELLIASAVTSVPTEGGDIGKETEFQLEGDLLTGKTIKLVYGDYAEEMKAISEYIKKAQENSSNEIQAKMHEAYAKSFSSGSLLDFKDSQRYWIRDKGPMVESNIGFIETYRDPAGIRGEWEGFASGTYTHHPFLDRILTTFERTRAFGELVSSAPKLIPLLPWSQDFEKDKFLSPDFTSLEVLTFAGSGIPAGINIPNYDDIRQTEGFKNVSLGNVLSAKAPNEKIPFISEADLELYHKYRDPAFEVQVGLHELTGHGCGKLLQETSPGTFNFDEKNPPVSPLTNKPVTTWYKPGQTWGSVFGSLAASYEECRAELVAMYLGCEFPVLKIFGFGDGTTDINNEAGNVLYAAYLQMARAGLVSLEMWDPKSQKWGQAHSQARFSILQCFLQAGDDFCKLEYKNDDLSDLEIKLDRSKILTTGRDAVGKYLQKLHVYKVTADVENGTAFYKEMTNVDMDFWGTKARNVVLKNKQPRKVFVQANTFLDEASGKVSLKHYEASPVGMIQSWADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUZ7</accession>
    <name>A0A1B7YUZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_01051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164388.1">
        <property type="nucleotide sequence ID" value="XM_018296026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUZ7"/>
    <dbReference type="GeneID" id="28860133"/>
    <dbReference type="KEGG" id="chig:CH63R_01051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01051"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="87" mass="9316" checksum="042F266836B73028" modified="2016-11-02" version="1">MKPVVSAMQAWQCTVISVFGIVILGVLGILFSQNHPELVGGDEDPKDGSAVAGTIFISVLIYIGFFVFCGLQGLLHIRENRRGAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1UUY1</accession>
    <name>H1UUY1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rare lipoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_04336</name>
        <name evidence="5" type="ORF">CH63R_01326</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000099">
        <property type="protein sequence ID" value="CCF31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164663.1">
        <property type="nucleotide sequence ID" value="XM_018296301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UUY1"/>
    <dbReference type="STRING" id="759273.H1UUY1"/>
    <dbReference type="GeneID" id="28860408"/>
    <dbReference type="KEGG" id="chig:CH63R_01326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01326"/>
    <dbReference type="eggNOG" id="ENOG502S9P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026963_3_1_1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000125">
        <property type="protein sequence ID" value="CCF31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR07117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155635.1">
        <property type="nucleotide sequence ID" value="XM_018303612.1"/>
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    <dbReference type="KEGG" id="chig:CH63R_08638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08638"/>
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        <property type="entry name" value="Nuc_deoxyri_tr2"/>
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        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07117.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="166" mass="18554" checksum="AB35DD6144479445" modified="2012-03-21" version="1">MEGTPPNPGKVVCPLERPPAMTGRSVFFAGTTSKGDWRKHLADSISHLPVTVFNPFRPDWDSTWREDVSDARFKGQVEWELEMQERADIIVVYFEPDTEAHISLLELGLCARSGKAIVACSEGYKKRGNVQVVCARYGIPLVDSYDALRERLVSELQGASINSKTR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1UV19</accession>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000144">
        <property type="protein sequence ID" value="CCF31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160562.1">
        <property type="nucleotide sequence ID" value="XM_018299316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UV19"/>
    <dbReference type="STRING" id="759273.H1UV19"/>
    <dbReference type="GeneID" id="28863423"/>
    <dbReference type="KEGG" id="chig:CH63R_04341"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04341"/>
    <dbReference type="eggNOG" id="KOG0460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="445" mass="49119" checksum="C379AA7085FB8DD9" modified="2012-03-21" version="1">MSASLRSVAPFLRTARASLRQGNVSPLQAALKRKNVSPVLNIYRTYAVFERTKPHVNIGTIGHVDHGKTTLSAAITKRQAEKGLANFLEYGAIDKAPEERKRGITISTAHIEYSTDNRHYSHVDCPGHADYIKNMITGAANMDGAIIVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAIDDPEMLELVEMEMRELLSTYGFEGDETPVIMGSALMALNNQRNDIGNEKIDDLLKAVDEWIPTPSRDLEKPFLMSVEDVFSISGRGTVVSGRVERGLLKRDTEVEIVGKGDVIIKSKVTDIETFKKSCEESRAGDNSGLLLRGVKREDIRRGMVVCKPGTVKAHSRFLTSLYVLSKDEGGRHTGFHENYKPQMYLRTADESVTLNFPEGTEDASTKMVMPGDNVEMVATLHNPSAIEVGQRFNVREGGRTVATGLITRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW96</accession>
    <name>H1UW96_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_04669</name>
        <name evidence="12" type="ORF">CH63R_00491</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CACQ02000367">
        <property type="protein sequence ID" value="CCF32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163828.1">
        <property type="nucleotide sequence ID" value="XM_018295466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW96"/>
    <dbReference type="STRING" id="759273.H1UW96"/>
    <dbReference type="GeneID" id="28859573"/>
    <dbReference type="KEGG" id="chig:CH63R_00491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00491"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_1_1"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
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        <property type="term" value="P:regulation of mitotic recombination"/>
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        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
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        <property type="entry name" value="DNA_brk_join_enz"/>
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        <property type="entry name" value="TopoI"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="436"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="801"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="248"/>
            <end position="258"/>
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            <begin position="259"/>
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            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="875"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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        </source>
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    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="918" mass="104188" checksum="7D10BE0F2D6BD44F" modified="2012-03-21" version="1">MSSSDDDAPLARSNGHISASRVSKADDFDMDRTASKARAAPPGLSIRHGPVDDEFMDIDGPSTNGKRKSRSSLPKVNYKVDTESDDDAPLAKRQKTKPKIPETDSDDEPLTSKRGKNLPPSYKETALPDESSDDDQPLGAKLAKKKADIEKAAAKEARTIRASEAKAKKATPKKAVKEESSDDEPLAKSATKKRQSNGAGSAKRKSNGMKVESDSDEPIAKKVAKKGTPAKAPAAKGKAAASAKAPGKKADSKAKQESEAPEEEEEEEYEWWKDPKKEDDSVKWTTLEHNGVMFPPEYQPLPKNVKLLYDGKPVNLPIEAEEVAGFFGAMLNSKHNVDNPVFQKNFFDDFKAVLKESGHATDKQGNKVDLKEFSKMNFEQIFQYYEQQSAIRKTRSPAEKKAAKAEKDELEAPFMYCKWDGRKEKVGNFRVEPPSLFRGRGEHPKTGRLKKRVYPEQITINIGKGAKIPEPPKGHKWKTVVHDNKATWLAMWQENINGAYKYVMLGAASAIKGQSDMKKFEKARELKKHIDKIRRDYTKDLKSEVMADRQRATAVYLIDKFALRAGNEKDAENEAETVGCCSLKYEHITLREPNTVIFDFLGKDSIRFYDEVTVEKQVFKNLKLFKKPPKTDGDDIFDRLTTTQLNNHLKNYMPGLTAKVFRTYNASFTMSTLLQKLVDHKNLTIAEKVKLYNDCNREVAILCNHKRTVGAAHEAQMEKLGDRIKGLRYQQWRTKMMMLQVDNKIKKKKGADFFVRPEDLTDEWVLEHQQFLVEEQRGKITKKFEKDNEKRLAEGQKPFPDKELKERLKAADELAAKFKKENKSKKVEPEGRSPSVEKLDEQVKKFDDRVKTLELQAADRDGNKEVALSTSKINYIDPRLTVVFAKKFDVPIEKFFSKTLRDKFSWAIKSVEDEDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWA0</accession>
    <name>H1UWA0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_00775</name>
        <name evidence="2" type="ORF">CH63R_05586</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000369">
        <property type="protein sequence ID" value="CCF32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158411.1">
        <property type="nucleotide sequence ID" value="XM_018300561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWA0"/>
    <dbReference type="GeneID" id="28864668"/>
    <dbReference type="KEGG" id="chig:CH63R_05586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05586"/>
    <dbReference type="eggNOG" id="KOG1611">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_2_1"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="270" mass="29358" checksum="D7A41E3114FE1343" modified="2012-03-21" version="1">MPSYLVTGVNRGIGWAFLRKISDDPNNTIIGTVRDKASVEKKIADELGSRSNIHIVEVEMASYDSIKKSVDIVSQITGGKLDYIIANAAYISDWQAFEPIGKLGENPTKLEDDLLQSFKVNVVGIVHLFNLYTPLVLQGDVKKVITLSSGMADIDLINQYRLYNSAPYSISKGAVNIAVSKFHAQYAADGVLFMGICPGMVETGHNSNLQPDQLEGAQKVAAIFNEYAPGAGSRAPEDSVNDVMKVIYESSLENGRGGAYISHLGSKRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWV0</accession>
    <name>H1UWV0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_04839</name>
        <name evidence="10" type="ORF">CH63R_07215</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000428">
        <property type="protein sequence ID" value="CCF32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156968.1">
        <property type="nucleotide sequence ID" value="XM_018302190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWV0"/>
    <dbReference type="STRING" id="759273.H1UWV0"/>
    <dbReference type="GeneID" id="28866297"/>
    <dbReference type="KEGG" id="chig:CH63R_07215"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07215"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_3_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="58"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="52146" checksum="F4F93AB0BFF72167" modified="2012-03-21" version="1">MRLSKTLAFAALLNESASSKVVSANFHRVQFPVDLVQITRRGDTLNLAAINNITGGGYYSEVYIGTPGQKTLLHLDTGSSDTWVVDKQADLCISRSLQAQVGGGCVKPIDSSASSTFKVVSRNGFDITYLDGRNIRGDYIQDTVSFDGKTTTNQQLGFATQTVKGSGLMGLGFSEGVSSRRRYPTILDSMVAQGHIGRKAFSMWLNDLSSSEGTVLFGGVDTEKYVGTLTTLPLVEDPNSGSITSYSIAMTGVAVETPDEKLVQMTAGSFNATTILDSGSTVCLFPERLTKSIWAKFGVVDAGYGLIDCKWRGAMGEGHFIDFDLARVKIRVPLEEMVLDNLDRIMDQLDDLTPFDRTCMFGIQNSAIFDVTSSRFAILGDTFLRSAYVVYDETNQQVGIAQANLNSSRSNIIELRADGSALPTATGVASQVTTPAPTRTASGGATHLVSTASSTPTAGESKSAASHHTVVLLGILVLLQAFEGQRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UY23</accession>
    <name>H1UY23_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_05174</name>
        <name evidence="6" type="ORF">CH63R_07384</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000567">
        <property type="protein sequence ID" value="CCF32874.1"/>
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    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08619.1"/>
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        <property type="entry name" value="STAM"/>
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    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
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        <location>
            <begin position="107"/>
            <end position="168"/>
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            <begin position="50"/>
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        <location>
            <begin position="181"/>
            <end position="207"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF32874.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR08619.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="270" mass="28873" checksum="C85956F5205C03DE" modified="2012-03-21" version="1">MDRQTIIETNRSLRTIKNELENLLEKGVISEDAYDNIHATLPAETPLHGAASRAAPNAATPVQNNPTSPPPTNAMAALNVNPSPSPAPPSYNQTGPPSLPARTNEKPVLAHARALYRYAGADARDVALERDDRIAIHEYMNADWWMGRNLRTGQEGIFPKTYVLVEQDSAKGAFAPPPAQPQYAPQPQAQWAPQPQYGTPQPQYAQPQGPPPQQNPYNADAPPQAVADQSTGGKDGKGAEMGKKFGKKLGNAAIFGAGATIGSNIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UY82</accession>
    <name>H1UY82_COLHI</name>
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        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
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    <gene>
        <name evidence="16" type="ORF">CH063_05214</name>
        <name evidence="17" type="ORF">CH63R_11909</name>
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    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000584">
        <property type="protein sequence ID" value="CCF32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306883.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UY82"/>
    <dbReference type="STRING" id="759273.H1UY82"/>
    <dbReference type="GeneID" id="28870990"/>
    <dbReference type="KEGG" id="chig:CH63R_11909"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11909"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1570519_0_0_1"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Rech G."/>
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                <person name="Rounsley S."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Will I."/>
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                <person name="Dickman M.B."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </evidence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Sykes S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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    <accession>H1V1B5</accession>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Glomerellales</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02000979">
        <property type="protein sequence ID" value="CCF34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165092.1">
        <property type="nucleotide sequence ID" value="XM_018296730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1B5"/>
    <dbReference type="STRING" id="759273.H1V1B5"/>
    <dbReference type="GeneID" id="28860837"/>
    <dbReference type="KEGG" id="chig:CH63R_01755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01755"/>
    <dbReference type="eggNOG" id="KOG1661">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_0_0_1"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="239" mass="26123" checksum="C6E85E4937F8FAA2" modified="2012-03-21" version="1">MAWRSSGATNEELVENMWKRGLIKDQRVKDAFLKVDRAHYAPGAPYEDSPQSIGHKATISAPHMHATAAESLLPHILPSDKKPAPRVLDIGSGSGYLTHLLAELAGEKGLVVGLEHIQALRDLGEKNMGKSAEGRELLESGRVRFHIGDGRKGWTEPPRGREEAAGTGWDAIHVGAAAVELHQDLVDQLRAPGRMFIPVEDDNGHGQYVWAVDKKEDGSVVKERLFGVRYVPLTDAPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2M8</accession>
    <name>H1V2M8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06470</name>
        <name evidence="3" type="ORF">CH63R_05588</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001158">
        <property type="protein sequence ID" value="CCF34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158413.1">
        <property type="nucleotide sequence ID" value="XM_018300563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2M8"/>
    <dbReference type="GeneID" id="28864670"/>
    <dbReference type="KEGG" id="chig:CH63R_05588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05588"/>
    <dbReference type="eggNOG" id="ENOG502T58I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_877189_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555496" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35771" checksum="DE96AD1CD55879E0" modified="2012-03-21" version="1">MRFILLIQQLFLLVIAAQIHNQIAPRGFKFVGKKKGAVGGCEAEDVAIILKELEIAQEAAEFAAEHFTEYPYFRAFQAPEHPFFKGKKLERAAKQLFTRTAKILDGFHKDDKFRIECRSMLCLVAGGDSAALVWERRKSSRFGPNVPVMAFCRDFFETPQDATAFASTEGRLRQFREVLDKNPKDIDTGSTIVNMRSVGNMRSQIILHELTHTSYVAKPVIELLNRKAETELKTLDDHTYDPLVCYQTARGIFDRKTEKKPDLLEGAKRAAENAESWGLIATGTYMSKQLGIEQIPIPGVPNHEWAYTDKTGGNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3J7</accession>
    <name>H1V3J7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_01203</name>
        <name evidence="15" type="ORF">CH63R_09919</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
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        </reaction>
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    </comment>
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        <property type="entry name" value="GH"/>
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    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
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    <dbReference type="PANTHER" id="PTHR16631">
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    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
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    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497575" description="glucan 1,3-beta-glucosidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF34799.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="OBR05799.1"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3Q4</accession>
    <name>H1V3Q4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pectate lyase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_01213</name>
        <name evidence="8" type="ORF">CH63R_10571</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001301">
        <property type="protein sequence ID" value="CCF34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR06451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154969.1">
        <property type="nucleotide sequence ID" value="XM_018305545.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V3Q4"/>
    <dbReference type="SMR" id="H1V3Q4"/>
    <dbReference type="STRING" id="759273.H1V3Q4"/>
    <dbReference type="GeneID" id="28869652"/>
    <dbReference type="KEGG" id="chig:CH63R_10571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10571"/>
    <dbReference type="eggNOG" id="ENOG502S66G">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497583" evidence="5">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="55"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="331" mass="34533" checksum="E0E7923260E1F4C0" modified="2012-03-21" version="1">MKFSGFASWALLAAAVSAIPTSIVEEGHLLNKRAAITDAANIGYATQNGGTKGGVGGTTTTVTNLAQLSAAANASGPGIVIIQGNIVGKAKVQVGSDKTIVGKTGSSLEGIGLTILGQKNVIIRNVKISKVEAAYGDAITIQLSKNVWVDHCDLSATRDGDKDFYDGLTDLSHAADWVTISHTYFHDHSKGSLVGHSDNNAAEDTGTLRVTYANNHFFNVRSRGPLLRFGTAHVYNQYYNTMDTGLNTRMGAQALIQSSVFENVGKKAIFSESSKETGYAVAIDVVLGGQSANTAPVGKLTASSPPYSYSLLGSANVKAAVTKEAGQTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5Q6</accession>
    <name>H1V5Q6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07313</name>
        <name evidence="4" type="ORF">CH63R_05674</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001588">
        <property type="protein sequence ID" value="CCF35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158499.1">
        <property type="nucleotide sequence ID" value="XM_018300649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5Q6"/>
    <dbReference type="STRING" id="759273.H1V5Q6"/>
    <dbReference type="GeneID" id="28864756"/>
    <dbReference type="KEGG" id="chig:CH63R_05674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05674"/>
    <dbReference type="eggNOG" id="ENOG502SBSZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024587_1_0_1"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="557" mass="57703" checksum="C7CCB6529CFBC5EF" modified="2012-03-21" version="1">MEIEVDADLLRTVATGGQMDYGLWPALSQGIISRLDKIAHNEFPIPNLPNPPQPINAPGQQPRLLSPLPSSSIEPASSLPSSQDADKENSKPNVPASSTVPAETEAANTAADASSVSEATESLPVQITAMLDEINSVLSTFPKYPPHTIQRLAELVLEPRRHYRHLASYLHAVDRVVHVTSGANIYPLPPAIPDMSTMTLLSNGSANGQENPAAAAAAAVAWSNSTNSVASTVGTDEALGGALLTPIPWLTRRPSPGSSSPASSNGGGPAEIRTESTETIDGPNGVGSIETVSVSVNGIPSMGASNSSRAITQGELLRQEQEQGVVPVNQLVRQAEEAQHAAALRSGDGVRASSPEKQHQHQHQQQEHAAAATATSDAGAAVAEEEEEESETPHARGPEEIGVGDLGPQSETTSFISGALGLEMQGIDVEAAVGRKAEQTHATPPPEDAKKEDDAAEAIVDDAASDTSVTSHAKRDADEELDGLASKKVKEHEGDVAGEVSKATVGSPKEGDAEAVAGAVDAKTENIEEKAEVKADGATAEAANEAEVATETKKTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6Q3</accession>
    <name>H1V6Q3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01397</name>
        <name evidence="3" type="ORF">CH63R_10184</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
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                <person name="Schulze-Lefert P."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02002429">
        <property type="protein sequence ID" value="CCF37357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162417.1">
        <property type="nucleotide sequence ID" value="XM_018297601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAV4"/>
    <dbReference type="STRING" id="759273.H1VAV4"/>
    <dbReference type="GeneID" id="28861708"/>
    <dbReference type="KEGG" id="chig:CH63R_02626"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02626"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF37357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="241" mass="26859" checksum="F848E02D35D92231" modified="2012-03-21" version="1">MNTTLSAVKVVLLDIEGTVCPISFVKDVLYPYAVDALPATLDKQWDNPDFAVYRNAFPEDCVSDRSAFEAHFRDLVRRDVKASYLKALQGYLWKEGYRSGEIKAPLFPDVSERLLSWRDAGLRLVIYSSGSVPAQKLFFGYTDAQPSDLTPLVSDWFDTVNAGLKTEPSSYASILSNFEDTKPEEWLFLSDNPHEVLAAIAAGMQSIPVVRPGNAPLPTDLNPTLQPIRDFNELEDLGSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBL6</accession>
    <name>H1VBL6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAPP complex protein TRS85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08909</name>
        <name evidence="3" type="ORF">CH63R_04950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002551">
        <property type="protein sequence ID" value="CCF37619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161171.1">
        <property type="nucleotide sequence ID" value="XM_018299925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBL6"/>
    <dbReference type="STRING" id="759273.H1VBL6"/>
    <dbReference type="GeneID" id="28864032"/>
    <dbReference type="KEGG" id="chig:CH63R_04950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04950"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014185_0_0_1"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="770" mass="84761" checksum="6DEBEC0F12697295" modified="2012-03-21" version="1">MESLDNDVPPTDPLQALPMAASTARLPKRQSVPEGHPLSQSETTLPYRRSNPSVAPLFASTLTPPGSRSGSPMGRGSPARPLSGSVFGGPAGRSLIDDASDSPGDPRNLIMKAYVPHVAIYASPDTEELAKDKGFKNGVWELLRPFGEQIQGKVTIRDSNGASRSWEDYSVRFVKFGENIEPPGAGGAKGAQSAVSNGQSGSALGSRSNYEDVENVVERHLSYAEESFLNTPHHGLTRQGLDVEATSPYYSLYLRRLLSGIPVSPHETFAHPVACVIAISSRSPSPIDDLRKLYNDTSSGENRLPVWVDGDYLRYYVLVHDEERDDITRSLALFDQMKRHLGLHCHLLRLRSTQSAETDDDSIPLPRSDWMSAAEEMADIRHSEDQEDFEDPTRHIFESDATAIRTFVREMVTQSIIPTMERHVSLWNDQVASRRRGITGRFMNLSRKWGGFGSSSRNSVVGGSSSSSAYDTLGFYRADASEAIMRKLADFAFMLRDWKLAHSTYDLLRSDFSDAKAWKYHAAANEMAAASLLIMPQSLPSKSRGETIDQMLEAAFYSYHTRCSSPFGALRSLTLGIELLRLRGGSCIDDAVRWGIRLLDSKILGSVGDALMKERLAVCYASKPGVGSGAWGHRKRKSAMWCILAGEAWHTQQKYIQSQRCLNEAGRIYSEFPHENGISKFNLANDFVSGLQHDLDDKLDVNGEGNQSPSQGVEELIVDEESEPLDLRSRRASMMGRGAVPAASLETAPLHEVTSPVKEKADGSVQDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H1VD78</accession>
    <name>H1VD78_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline serine protease Alp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_09340</name>
        <name evidence="11" type="ORF">CH63R_13070</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002852">
        <property type="protein sequence ID" value="CCF38181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152461.1">
        <property type="nucleotide sequence ID" value="XM_018308044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VD78"/>
    <dbReference type="GeneID" id="28872151"/>
    <dbReference type="KEGG" id="chig:CH63R_13070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13070"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010965631" evidence="7">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="164"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF38181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR03943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="427" mass="44152" checksum="75B23F822815438D" modified="2012-03-21" version="1">MKASSLLALLGAVVPALAANKYIIQLKPGTSPDAVTRHHNAVRSLLRRRDGSAEGTLDKTFRIGDDFNAYSGSFDDAALEAIAALDEVLAVELDQPILVDPTEAEQTLFSLSSESESSAASSSSSSFARRRALTTQPNSIWSLGDLSHRAAGSTEYVYDSTAGEGTTAYVFDTGIRLSHAEFEGRASFGINGVTGSTVSPGSNSDTDGHGTHVAATIVGKTYGVAKKAKVIDVKVFDGSTGSTSAILTGLDWAVKDIVSKGAQKKSVLNMSLSANNVAALDNAVLAAYRQGILTIVAAGNDNQPATTTSPARLPEAFTVGMTRPDRGRVNIIEGIYGSSYGPELDVFAPGQDIVSASHTSDTGTATKTGTSMAAPLVAGLVCYLRGLAGGFGTPKQVTDRILELAIPGVVGDPKNSPNLLVNNGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEJ4</accession>
    <name>H1VEJ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01952</name>
        <name evidence="7" type="ORF">CH63R_04206</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003079">
        <property type="protein sequence ID" value="CCF38647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160427.1">
        <property type="nucleotide sequence ID" value="XM_018299181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEJ4"/>
    <dbReference type="STRING" id="759273.H1VEJ4"/>
    <dbReference type="GeneID" id="28863288"/>
    <dbReference type="KEGG" id="chig:CH63R_04206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04206"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF38647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="41660" checksum="82BDCC0269113E29" modified="2012-03-21" version="1">MPTLVILGAGIAGLPIAHHVLKHTTPLVKDLKVILVTPNTDHYWNLASVRGVVPGQLGDDKLFQPIAPEFAKYPKESYELVFGKAETLSDDKKTVIVKTNDGAHRTIAYDAVVIATGTRSKENMPWKEVGTTEETKQALGSLRKQIADAKTIVVAGGGTTGVETVGEIGFEFNGKKDVYLVFSSDLPLAEPLNDNVRKAALNELRKMNVKTIPNTKVTSVSTGADGRKTLELTDKSGKTTTLQADAYVPTTGNVPNTSFLPASMLDTQGYVNQDASLRVPGHENIFVVGDVGNLEDGYARLADQQTQHAVKSIQAHFTGASRPADYVVDTKVLGAVTIGRSRATGQMGTWKLPSILIWLFKGRFLGTDYAKDVAAGKRTMLVTKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGL7</accession>
    <name>H1VGL7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_00321</name>
        <name evidence="16" type="ORF">CH63R_02790</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003457">
        <property type="protein sequence ID" value="CCF39370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018297765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGL7"/>
    <dbReference type="STRING" id="759273.H1VGL7"/>
    <dbReference type="GeneID" id="28861872"/>
    <dbReference type="KEGG" id="chig:CH63R_02790"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02790"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="277"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF39370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="57349" checksum="4041EC49F779E924" modified="2012-03-21" version="1">MVVLAASICTRGGKAVLSRQFREMPRSRIEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVTSTCKSLDEREILKNAYELLSAFDELVTLGYRENLTISQIKTFLEMESHEERIQEIIARNKELEATEERKRKAKQLEMQRKESARAGRVGGGMPRTPVYPTYTPPTRPTPTDTYDSYEAEKNKTFNKLNAPKGKGMQLGKKSKTTDMFERVRGEMGAEVDDTPLVTPSPAHVPEPAAEPRVSSTLDRDAIHVVVNEAISAKLSREGAINSLAIVGDLSLRISDPSLTKVKLNLTANASHGAQFRTHPNVDKNLFNSSKVIQMSNTARGFPTNQSVGVLRWRATAKADDASACPITFTVWINKDADKYNMTVEYELTGGDTLKDVSVIIPYQASEPVVSSFDASYEVSGDSLEWNIGTVSEENPTGSFEFEAETNDENDFFPMTVRFSKTSPFIDVDVSTVSLLEEDEEVTFSKEVKSNADNFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VI10</accession>
    <name>H1VI10_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_10579</name>
        <name evidence="18" type="ORF">CH63R_10019</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="CACQ02003741">
        <property type="protein sequence ID" value="CCF39863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154417.1">
        <property type="nucleotide sequence ID" value="XM_018304993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VI10"/>
    <dbReference type="GeneID" id="28869100"/>
    <dbReference type="KEGG" id="chig:CH63R_10019"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10019"/>
    <dbReference type="eggNOG" id="KOG2088">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001871_0_0_1"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF7">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="841"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="380"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF39863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR05899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127411" checksum="FF3F3992801132A8" modified="2012-03-21" version="1">MDNMDSDDDWDADEHSHDLIHIPLEPHQGRTILPAPIAKAVSLATRSTCLAIRVGTLVSSYGFDAAKFTTLSSLELGRGILEGILSRSGRDMLVRSNSDLGREDAETVLERSLEHLHHAMSQIVFWTTTGFQMTSTTFSVVSEVSQLLLSSLDQFFGSTDSSRAIASIITLIRREFQNPATGVEGERVGVVDLVMGLCALAYLQRKCRRFLDEESRRLGHDEIVWDVVVLNDGERVDIHENSLYGVHKGRYKSKGPDILVSIPGDQPSPSILATIERHGERETSEDEDDDDLPEIRLKNQIMRSMPSDTSVSISTTTLTRKMITVDFTGPEPPTLTPPPGVEVVEREVLPSAEYQKEQPTRQHAVADVPTYRVVYRVDKSKQRSTTFRGYEEPEETTRKVESLDDTEDSDAFGRDGDNDDPPPPVPPKPALPVVAASSSRAEATSNSTPRRTKVGSGVPSTSPNSRASQIPTPKQNPENAPNQKRQRAPLAPLPARPRHENAVSSHSETTKAKRIKGDSLPTSKPSEKPAEKKSGIRQALKRGTSSNISNLFHRDGAGTTSSQSAGKAKQTPRAGPAERTTRTPTQSSRPSQNRAMGPTASSSSRGRNYENPSPVPRSSSRASYISVHERRRDSIVSQTETYSFHAVDGLRPQSPGYGRRDGMGQSSIPKSRSEKDMNDQKPPSPMKSRRARSHVNTPSLYSIANTGSQTSLVLSSYYQKSAYTDSEAIDTLRRAGTVDGVFPAFHLLRNITRYMRFSSASYGSNFLKFMGISKEMPLLRALDDTHHEIRSFAHHTESEAASILLASFVDSQGGSDTTGSTGTGVPLVHYISLDHESKAVVLACRGTLGFEDVLADMACDYDNLYWRGKSYKVHKGIHASARRLLYGGDGRVLYTLKEALDEFSDYGLVLCGHSLGGGVTALLGTMLAEPSSTGTGFVTTSEPHRRLLGDGRFLETDTTHVCLPSGRPIHVYAYGPPGTMSPALRKATRGLVTSVVHGCDLVPFLSLGVLHDFQAVALAFKSDNHEAKVEVRQRIWQAFQTGLAEKWYTSSSRSMVADEDKWSISALTTLRSSMMSLKLLPPGEVFIVESQRVLRRDAFLLSDEESIGRPAQRIVLKYVRDVESRFREVRFGTSMLIDHSPAKYEDALNKLRFGVVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJB5</accession>
    <name>H1VJB5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10917</name>
        <name evidence="3" type="ORF">CH63R_08748</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004006">
        <property type="protein sequence ID" value="CCF40318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155745.1">
        <property type="nucleotide sequence ID" value="XM_018303722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJB5"/>
    <dbReference type="GeneID" id="28867829"/>
    <dbReference type="KEGG" id="chig:CH63R_08748"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08748"/>
    <dbReference type="HOGENOM" id="CLU_2277307_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="102" mass="11189" checksum="8FCE72904DC2D0C5" modified="2012-03-21" version="1">MNNRQRLTLPPPLGLGWSSQNSPSRRLAYHTSGSPEAAAVDRLLAEELDAYSVSWPVTGLSVVTGGRRDQDEDQNQNQNQNQNQIWTPSRWIVTGCLGEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKT8</accession>
    <name>H1VKT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ethyl tert-butyl ether degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02447</name>
        <name evidence="5" type="ORF">CH63R_03442</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004334">
        <property type="protein sequence ID" value="CCF40841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163233.1">
        <property type="nucleotide sequence ID" value="XM_018298417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKT8"/>
    <dbReference type="STRING" id="759273.H1VKT8"/>
    <dbReference type="GeneID" id="28862524"/>
    <dbReference type="KEGG" id="chig:CH63R_03442"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03442"/>
    <dbReference type="eggNOG" id="ENOG502SQ1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115019_3_1_1"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497692" evidence="2">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="176" mass="19574" checksum="42D0FE01F7421D13" modified="2012-03-21" version="1">MLLSAPFALAAMALTTSFVSGTSTGQTQLVTYLKKGANLTRAEFWDYWQTQHAPKVAPLAVHLGITRYQQIQVSGQVLPTLVGRDEPSSEVPVEFDGIAMLLYPSVEVIHAFVTHPYYTDVVEPDEHNFMDKSAFGAGMVATFRGTQIEVADDNEYVWTGDRATRQLYMDLFATYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLC5</accession>
    <name>H1VLC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_11433</name>
        <name evidence="5" type="ORF">CH63R_07499</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004449">
        <property type="protein sequence ID" value="CCF41028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157252.1">
        <property type="nucleotide sequence ID" value="XM_018302474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLC5"/>
    <dbReference type="STRING" id="759273.H1VLC5"/>
    <dbReference type="GeneID" id="28866581"/>
    <dbReference type="KEGG" id="chig:CH63R_07499"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07499"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_4_1"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="198"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF41028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="689" mass="78631" checksum="AC800AB6806211DE" modified="2012-03-21" version="1">MLRHSIAGLSARAPAQKCFLSASAAAVAGRQSLRNSKTIPTITTITTTTTSRLLSYTRTARIRTSSHRQALVPPSPASLGAPRKARTYPRGSKWLRRLLVLSAVGGSIYLFDRQVYASGLGRTLRTFSMGLVVALDYKVNFRPEPLTGGSVQDLHHRNAERLFELLRHNGGLYLKIGQAIAMQSAVLPPEFQKMFSRMFDDAPQDDWRDVEAVIREDFGGRSVEEVFGVSFRGEEGKGVMERRARASASVAQVHWARLPDGREVAIKIQKREIAKQISWDLWAFKTVAWIYSKWFDLPLYSLVPFITERLELETDFLNEAKNSETMRELIQSEKSLRGRVYVPKVYSELSTRRVMVTEWIEGIRLWDKQGINGRWMGGYGNGSPGVQGASLQPPDMATVRRELRERPYAEQIKPERAEWKGRRGRGGLGLSSKEVMTTMIDLFAAQIFKWGVVHCDPHPGNIFIRRLPNGRAELVLIDHGLYVYMTDRFRHQYGVFWKALMTFDNKTIERVTEEWGIKAADLFASATLLRPYEGGDERTRNGLMKELEGKTPAERHYEMQQRMKQGIREMLADEEKWPKELVFIGRNMRIVQGNNQYLGSPVNRVKMMGEWASRSLFEDPNLPWASRAGNAWRHLLFKGVLALTDIAFYFFKLKQWLGVGGGMEDEMEKRMKDIAQDFGVELQHEVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VMF0</accession>
    <name>H1VMF0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00394</name>
        <name evidence="12" type="ORF">CH63R_03177</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02004679">
        <property type="protein sequence ID" value="CCF41404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162968.1">
        <property type="nucleotide sequence ID" value="XM_018298152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VMF0"/>
    <dbReference type="STRING" id="759273.H1VMF0"/>
    <dbReference type="GeneID" id="28862259"/>
    <dbReference type="KEGG" id="chig:CH63R_03177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03177"/>
    <dbReference type="eggNOG" id="ENOG502SBB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_1_1"/>
    <dbReference type="OrthoDB" id="3192019at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF41404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="197" mass="21618" checksum="4E4F24A0987DBCF9" modified="2012-03-21" version="1">MKEPLRRLRYNVAVSLDGFIAPLDGTTDWIVHDDSIDLDALDAQFDTFVMGRKTYECLSDMGELNPLRNHPPQNLVVVSKTLKGEQHPGVTVVSRDFVDRIADLKNAEGRDIWLMGGGQLAGPCLDAGILDSVETAIIPVMLRKGARMVPESPQATLGGFKLDLVECRQLEPSGIVRCKYNVSRQMAASLGEAMFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNJ2</accession>
    <name>H1VNJ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_11969</name>
        <name evidence="7" type="ORF">CH63R_05235</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004941">
        <property type="protein sequence ID" value="CCF41796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161456.1">
        <property type="nucleotide sequence ID" value="XM_018300210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNJ2"/>
    <dbReference type="STRING" id="759273.H1VNJ2"/>
    <dbReference type="GeneID" id="28864317"/>
    <dbReference type="KEGG" id="chig:CH63R_05235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05235"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_23_0_1"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03814">
        <property type="entry name" value="GT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="5">
        <location>
            <begin position="44"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="253"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF41796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="531" mass="58945" checksum="9BB7FB55E6E22F34" modified="2012-03-21" version="1">MDEPLLPMSYGTLPRYPARDNSVFPCSLRGKRILLCTESFGPVNGVSRTTLMLVEHLRSHGALVAVVAPHIHTQHNTFAPSSSSSSSSSAGGHSDSHIEVRLQGYPLPFNPELSVVYPVRVSALFARTFGADTPPDLIYLASPASLGFQVMLQLQQQPRARRVPVICNFQTDLAGYCAILFPHPFSTVAVFAFAMVQSFLFRHDSVKTVFYPSRFVRKYLEAQGVQGSKLEVLRRGVKTEVFRPEMRSPALRKLIAPDGEIILLCVSRVAGEKGFDFLAKAVKELDARGLRFKLYVVGGNRNPDVESQVHAMFDPLRAQGKVIFAGFKTGEDLATAYASGDIFLHCSVTETFGLVVLESMASGVPVVARDEGGPSDIIDDGHCGYLVPPDDLETFVDKVMYLSKDHSCRERMAVRAREMACEATWEKINNQVAWRMADTIEERERENAQLVHQRTSIAMQTSQTVPIHRWLLMGDAIRDVVVGRLVDAKLAGGLGVVMTFWFFTGLYLAFTETVLWFKGKLPRLWSQRTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPS7</accession>
    <name>H1VPS7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_12291</name>
        <name evidence="17" type="ORF">CH63R_06200</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="CACQ02005243">
        <property type="protein sequence ID" value="CCF42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159025.1">
        <property type="nucleotide sequence ID" value="XM_018301175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPS7"/>
    <dbReference type="STRING" id="759273.H1VPS7"/>
    <dbReference type="GeneID" id="28865282"/>
    <dbReference type="KEGG" id="chig:CH63R_06200"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06200"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="179"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="347"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="564" mass="63345" checksum="F4E86EDDDAD3D40B" modified="2012-03-21" version="1">MPAEESKPLDPAVKEANDALAEATDKGKGKEPEVESDEEDGEEDVPEEAAPGASAAGAKKKKKKSKRKKVKEALTGQPSDPEQKIKEAIGGLTPQQLTELLSLNPALANELGVGSSSNKSVEETAAAMQKLDLQDIMTGLASAGKNAKDMASYKFWATQPVPKFGESEKKIEDGPIRVQTVEEVPTEPSPMVTGFEWVTMNLEDDGEMKEVYELLNGHYVEDDEAMFRFNYSPAMLRWALMAPGWRKEWHVGVRASQSRKLVAFISAIPVDLRVRKNIVTCSEVNFMVVHKKLRGKRLAPVLIKEITRRSNLRGIWQGLYTGGVVLPKPVSTCRYFHRALNWQKLYEVGFSPLPPNSKPQYQIRKYQLPDTTSTKGLRELQEKDIDAARELLTKYLKRFDMAPEFSNDEFRHWFLHDKNAPGEQVIWTYVVETNGKITDMFSFYCLESTVINSSKHQVVRAAYLWYYASDVAFATPFNKDALKTRLNSLIGDALVMGKKYKFDVFNGLSLLDNGLFLEQQKFGPGDGQLHYYLFNYRAAPIAGGVDRRNKLDEENLSGIGLVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQ01</accession>
    <name>H1VQ01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_02797</name>
        <name evidence="9" type="ORF">CH63R_03741</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005290">
        <property type="protein sequence ID" value="CCF42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159962.1">
        <property type="nucleotide sequence ID" value="XM_018298716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VQ01"/>
    <dbReference type="STRING" id="759273.H1VQ01"/>
    <dbReference type="GeneID" id="28862823"/>
    <dbReference type="KEGG" id="chig:CH63R_03741"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03741"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_1_1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="517" mass="56331" checksum="5F101026AB8BD113" modified="2012-03-21" version="1">MADVKAPTDISSSPRRSVDAAPEKNLDADELRLAQMGHTQELKRHFSTLSLIGLASTTTISWTGLGLGLITEINAGGPGAVIYGFILVTLLQCFLGASLAEFVSSYPTEGGMYHWIAAVAPRRMTGVLSFFTGWFSVLGWIFTTASTNLIYAQVLMALIAVYHGDLEIQAWQTFIVYQGLNLITACIVMFGNKIIPGLNKFSLFYLQIGWLAVMVTVAACAPTHRDPEFVFRTWINNTGWENQVVCFIMGLVNPLYSLGGLDGVTHITEEMPNPSRNAPLAIAITLCIAFVTGITYLITLMFSIQDFDALSTTNTGLPLAELFRQVTQGAGGAFGLTFILFVALGPCVVSSQLSTGRVFWAFSRDGAMPFSRVWSRVHAKWQVPMNSQLAVTAIVAALGCLYLGSSTAFNSLLGTAVTINNISYMFPILTNLLTRRKNMHHGVFHMGPTLGPVVNSVTVCWLTFAIVFFSFPYVKPVEPANMNYTCVVVGGLTVLVGAWWLKAGSKYSEKMLQAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1VR09</accession>
    <name>H1VR09_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_12602</name>
        <name evidence="11" type="ORF">CH63R_13985</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005560">
        <property type="protein sequence ID" value="CCF42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151277.1">
        <property type="nucleotide sequence ID" value="XM_018308959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VR09"/>
    <dbReference type="STRING" id="759273.H1VR09"/>
    <dbReference type="GeneID" id="28873066"/>
    <dbReference type="KEGG" id="chig:CH63R_13985"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13985"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_8_1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="24076" checksum="92210C56DCF581DF" modified="2012-03-21" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDEEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEITTFQQQILRVKDKDYFPMVVVGNKCDLESEREVTRQEGEALAKSFGCKFIETSAKSRINVDKAFYDIVREIRRYNREMQGYSTGSGGASGINGPPKPMDVENGEQEAGCCSKCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTK9</accession>
    <name>H1VTK9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_03102</name>
        <name evidence="5" type="ORF">CH63R_02492</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02492"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="enoyl_reductase_like"/>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="ADH-like_N"/>
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        <property type="entry name" value="ER"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
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    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF43567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="354" mass="38066" checksum="8B84C31D32E2383B" modified="2012-03-21" version="1">MTTTAPQTCKALVIRAKDEKEEAFTLVQEQIPVPKPLPHQALVKVAVAAQNPTDVLCYDGGVFGDGSVLGCDFVGTVVAVGAEVTLIQVGDKIAGLIWGGEIKGQGAYSQYTIADEKICYKIPDGLSLEEAATVPLTATTAWLALFRSASLAIDRNKGSAINLLVWAGSTSCGLYAIQIAALFGFNVGTVCSPSQASRLRSLGANHVFDYKDPDVISKIKQAMPSVDYIFDTIGTESSSTLASQAMNPAGGTLCTVRPFREHTEDVTSQTKVTSLLVFTSFLKDHTMGSTLLPASEEDHRLASEFYERIPQLLRQGKIKPNSPQLIQGGLDGIQEGFQMYRDGKIRGNKLVYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VUR1</accession>
    <name>H1VUR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_13521</name>
        <name evidence="3" type="ORF">CH63R_14225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006522">
        <property type="protein sequence ID" value="CCF43970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151517.1">
        <property type="nucleotide sequence ID" value="XM_018309199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUR1"/>
    <dbReference type="STRING" id="759273.H1VUR1"/>
    <dbReference type="GeneID" id="28873306"/>
    <dbReference type="KEGG" id="chig:CH63R_14225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14225"/>
    <dbReference type="eggNOG" id="ENOG502TA13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066042_6_0_1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="266" mass="30230" checksum="E4A87A7459931070" modified="2012-03-21" version="1">MSDYNNLTEDEEKRHLVTSYFSSQPFRIFWFQNDDDAVTTSKNRQASRRKLHYLFASPHLYYSITILLILGVCIFQFISQHHLRPHLAPSHGTNPLCGSSPEEARAIGCTFDVYVNGWLPAACYDRAVAEQSESNSSDLHTSATGRATFPVYWDEAMTEPATLEDVMLAAFENGEDGYNVRFHTVWEYHRAHCLHLWRLAASALQRLSEGERNVGVYYKVASPEHVWHCNKVIIEGDARSPAKKDTITPGIGRCVWLGNLESVAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ24</accession>
    <name>H1VZ24_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00555</name>
        <name evidence="12" type="ORF">CH63R_10543</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
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    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
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            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
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            <name>Fe(2+)</name>
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        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
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    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10543"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="P:protein histidyl modification to diphthamide"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="InterPro" id="IPR036671">
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    <dbReference type="PANTHER" id="PTHR21454:SF31">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
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            <end position="64"/>
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        <location>
            <begin position="68"/>
            <end position="91"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
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    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF45486.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06423.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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    <gene>
        <name evidence="3" type="ORF">CH063_00560</name>
        <name evidence="4" type="ORF">CH63R_10537</name>
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    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007790">
        <property type="protein sequence ID" value="CCF45491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154935.1">
        <property type="nucleotide sequence ID" value="XM_018305511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ29"/>
    <dbReference type="GeneID" id="28869618"/>
    <dbReference type="KEGG" id="chig:CH63R_10537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10537"/>
    <dbReference type="eggNOG" id="ENOG502RFJG">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_108562_0_0_1"/>
    <dbReference type="OrthoDB" id="4799298at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF45491.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06417.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="16956" checksum="4B9A2AD9A00C9D75" modified="2012-03-21" version="1">MSLTLPFPTTRFGPGFTVPTAVTVTEGGRTITLTPSPTVGTPATSDASPFPDNILQQSGLAPGQIIGITVGATSSLVFLVVALVWFWNRRRARRLAARDEALDTVMEDPEKPDDAAILAHNAGETTELPAPRGLHEMPETREGPPVELPAPVERHEMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ69</accession>
    <name>H1VZ69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_14584</name>
        <name evidence="2" type="ORF">CH63R_10095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007828">
        <property type="protein sequence ID" value="CCF45531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154493.1">
        <property type="nucleotide sequence ID" value="XM_018305069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ69"/>
    <dbReference type="GeneID" id="28869176"/>
    <dbReference type="KEGG" id="chig:CH63R_10095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10095"/>
    <dbReference type="HOGENOM" id="CLU_2209855_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF45531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="107" mass="12358" checksum="F515AE0294A6FE06" modified="2012-03-21" version="1">MRATRATQSPANWGNVCTSCMASTAKEYLVLVAYDEREGKTRKTRTRHLSRLPLITFTGRTAPSASPVIRQINNKNAQPGRGRERERYLIFRYREPCYRQHNSNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1W0I1</accession>
    <name>H1W0I1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00587</name>
        <name evidence="8" type="ORF">CH63R_02144</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008235">
        <property type="protein sequence ID" value="CCF45994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161935.1">
        <property type="nucleotide sequence ID" value="XM_018297119.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1W0I1"/>
    <dbReference type="GeneID" id="28861226"/>
    <dbReference type="KEGG" id="chig:CH63R_02144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02144"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000592_0_0_1"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1267"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1671"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2007"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2513"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2766"/>
            <end position="2978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1841"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1111"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2563"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2624"/>
            <end position="2633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2639"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2766"/>
            <end position="2791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2810"/>
            <end position="2833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2834"/>
            <end position="2846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2871"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2928"/>
            <end position="2946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2969"/>
            <end position="2978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF45994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2978" mass="335920" checksum="ED636A2998109C3B" modified="2012-03-21" version="1">MAMLNPTFVFGVVVLLYLSSFILFAVVRILTGISIQRIGYFSLRRLAYTPRDGFKIEVRGLGLNVHRPTFAQPTWLSVVISELTVTIDIAELEGKKSDDSSTDSDNSDAEEETETQLPEQPKVPLLRRGTGGPPPRSETWKHLMKLKDRMKRAHRKLNWLRMVDVVASNSTIKVVDVGDVQFGSLTVAVDTRRKMVDRARFFFQSRTDRNKLKQRQAEWIMTLRSVLFTPEGKESLEILDNATLNIHGFLYEALDGLRDAAIALKLGRVHIPYDDVQLCADRLKQCKLAARSSPLSDEPADVFMDKIIHEVAQPGSTHQELIQTVSDSKEFISSILRGVKEVQFAVSFVGMTKRVESVKPSAKPVMLNASMKEVGIDLHRLDPKSPSHRMYFPSKDIAHEALAAALSISVGVDDGDGKPERLIYIPMATTTVKTTLPSKTVEMAQDVGAEERNANILFANSVVTSPSVDLDPRHLPLLVAMLKPKSSKRPRTNRQPRHMLISRLLPKANIKFTMHEPVLRVTLPAVDQHAASDDFDLIISSISSISLDMESFHSTVEDLHYSLASTMRIQSHELYYQTSSSNRFDLIQTESFELKVQLSATPDVHVVASGNLQTFSIKMVRPEITDGLRQIVRQLRMNVEPEKRSNSHTSIKKQNFLRAMPSWLLQLQLQASDFSVEIAGIDEDISDDTRGVSLQLDEFSAEYRAQRLDGLQRRPSRRRANSRTVAPDSDLLKSPISPPPRKKQQNEGDGRRVTFHVRGLEAYIVESEDRVELEPFVNMPRFEVAFQAMSDQQGPIFHIHAGIRTVLLQYSLFRHYSVGVAIMILRKAFMRSGQDIGSPPMSPTTPRKEASDFLAPPMSPEPSFADMTEHSTVTPELIAIDLKAALVQVKAELPNDPQLMLQVYGVEAGRHRWTSPFLASKLVRLYVQPPRMRTTWARMISIKGGRVDYRKSRRKLHNGGFHEDEMIDVNSDAIRFAVPHEVQVNRISDNVINTLKSIKQLHHRFKTGTNEYILDKVPGGPKNVPKVSVRTRSLLFELEDGAFEWKLGMIYRAGRVEQMQRLAREEAFEVKRKKIREEESRKESGKLRARSLFHRGRQQNGSSWARSQSADGRRPSTDQRSRGRAPRYDPDGGGIGLTGSASIAEQEARARLDAYNAESWKKRIDRFYVMAKNGMKEVRGLFWGPDQLPDDLEDTENILEVPQRPALMSALITDLQFVIDKPTFAMKDLPDFIHSVGKGMPKDMKYGLLVPMHVSIDLSEARISLRDYPLPLIHIPSLKTGQSTRLPAMSLKTNFVIAEEFRGMESTRRIKVNIVPPRNHEPGGSSEGSFAIDVRRTIGPVKSYSNMRIEINTALPTRITWGPAYQPAIQDMMMVIESFTKPQVDLSERVGFWDKIRLNFHSRIHVAWRGDGDMHLALKGTRDPYCVTGNGAGFLMCWRNDVRWNINADDDPKRFMTVDSGEYVLAIPDYSHQVREAAMRTGEDDSLLSEDSYKSGASFKKVVMKLSGKVQWMTGVVFERAIQDGRRSFEFRPHYDIVLRAPHHVKLDDQPYDAFRGFRSQHIHLSVAVRAPVDRDWMADNVEPSRSYNTVHCTPRFFTHFFSWWSLFGGAMALPIRQGSLWPGRARNSKKFGKHLSTIKYNLLLAPLFLSHIYKHKDAEDASDSGVSATGLKVRFDSFMLDLHQRREEFNTRDRGRKTKGKTSGIKLHAAQLDLAAADVRAVSASIRGTTTEAIKKGTIASLIANQSEDSADLSRFTIPDNDLSWIDMDDFVELDWILPTEPNPDTKILPLAFAPRLTYFRQTDIGGVISGDPDRKSPFGDEPTHFCIMSHDDDPRRVQAQLIQERLDQLEIQIENYGRSLGDAELRVVRDDAKDPKLVAAFESLQQQGAILQRKKTYLQNMLRQMNSKSPIDGSSFFKRENGSSKFEDSVQLEDDSLTIPSGAEFESDFNNRFVIHNLHFKWNNTLRNIVLRYIHQVSQRRGFVYYLSRPAVKFILDIVEEQYKAKQNPKPASKNRTPTGGATAGASPDLDAAEREFKQDIEDRIKNILKDGRNYVNADGKGGDDVPNVPIEDLSSGISDEFTPQNSYHVRLIAPQIQLQSDKNKKNVVILTSKGMELKVVEVMDKKRLADVVSGLVQRRFLVNMDSTQFFVTHQSYFSEIVTTYAGSRYGTPATSSWPPWVPMEVMFDFETDPFGFNRVVQKTSAMLRYEKYNTLRLKYNDEVNTEGAGDPSHSNNERKMDNLWVEFPQARALCNSGDYYAMYVIVLDLLMYNEPLEKTRSERLEKIMLASDFSDLSGTPEMVEKLQERIRQLQDIKSHFQIYSKYMDQRGWEDRLLLERDLAACEDELFFMMKAITSSQRRYETNSESNALLRWSITARDTVWHMLRDNKEPLVELQLKDVEYDRTDNADGSHINLIRVGKVFGLNLLPDAMYPEIIAPYVDGDKSTADLGNQEMIRVYWYMLEAIAGIPVMDHFEVNLFPMKIQLEREVGKRIFEYIFPGIDGDNKTKNDSPFMLKHTPAEDEEEDDDSLSGSGRLTASDKDGFNTRPGSLELRLHPTLNSDSPTKSISSKKSLTVNTGEGQGHTFRLFRSVGTGKVPSKKPSYESLKSTKEPRPGIGRTSTGFSSKESAAVSDSKKSRFGLRKESKAEENKPSDDLTKMMSRASNYMTFAHIKMPSVVLCLSYKGKDNRNVEDVHDFVFRMPAVEWRNKTWSNLDLALALKKAVIKALISHTGAIIGNKFKHRPSGAQASKLRELATGSSLIAPTPSSSSQHDADSINNSDDSSSLYGNSPVDYSRSPPRSRHGSSASSIPIPRSTSRSSSVASGRSQWTGGSSSQQPTVPSFLMMTPPTPLDSRAPTQGLGFELLRPSSRSSLAPFDQAGGGTMRSLSRSGTGAEPGDRRRSAGSAFLRDKINQLTHRKRDGAQQKESSQKQESQREETPEAEEEPNAVAPDSPKSSKRFQGLSSRVKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3P1</accession>
    <name>H1W3P1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_04043</name>
        <name evidence="13" type="ORF">CH63R_12958</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009368">
        <property type="protein sequence ID" value="CCF47104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152349.1">
        <property type="nucleotide sequence ID" value="XM_018307932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3P1"/>
    <dbReference type="STRING" id="759273.H1W3P1"/>
    <dbReference type="GeneID" id="28872039"/>
    <dbReference type="KEGG" id="chig:CH63R_12958"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12958"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_3_0_1"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="542"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF47104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="642" mass="70065" checksum="6283CDE79586B9B8" modified="2012-03-21" version="1">MPSDPAANLSALLRAASIEDHEEVLKAANATLKASSTDLVAQQTRVVALLKLDRFDDALRAIADGGSKLEDAALLEKAYALYKTGKLQDAHELANSRPQRSYRHLVAQVAYRAENFKDALEAYTNLLEDPQDEASDLKINQLASAAQLEWKSSANLDGDDTPIPTAEDADTFELAYNIACGTIARGELSKASNLLQRALRLCEESEELSDDDKSAEMIPIMVQQVYVYSRLGKAGEALEIQERLSISDEWDAESRLIALNNKSALATDAENAYLAQRKVDAAAVLSKQAKLFRYQDSQLKRNEYILGLHSQKFDGVYKNTSRSLDDAAPTVSVDTNSLSAINATAYALRHSKTVDFKGVLPLVERRPTDVGLLLTIVQLYLIANNTGAALSVLESFLQNLEKQGTSEVRFSPGLVALAVSLYRQQGRHSSIRSELANASSFWEKRDGRHVDSLLLGAGSELLKSSDPNDLTAAGAAFEKLCQKPSANHVAAAGLVASFATSDRAKVTPYLKDLPPVDDLLVGVDVDKLIGDGVVTHSKAASESKKRRLDAQPTETINKKKRRRKLPKDYVEGKKMDPERWLPLRDRSSYRPKGKKGKKKANEATQGGFVKEEETLELAGGAGSVKVEKAPTSSSKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5S7</accession>
    <name>H1W5S7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_04303</name>
        <name evidence="5" type="ORF">CH63R_04040</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02010211">
        <property type="protein sequence ID" value="CCF47841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160261.1">
        <property type="nucleotide sequence ID" value="XM_018299015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5S7"/>
    <dbReference type="STRING" id="759273.H1W5S7"/>
    <dbReference type="GeneID" id="28863122"/>
    <dbReference type="KEGG" id="chig:CH63R_04040"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04040"/>
    <dbReference type="eggNOG" id="ENOG502S8P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_0_0_1"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF47841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="134" mass="14917" checksum="04D28AF69806F97B" modified="2012-03-21" version="1">MMRQPITSLARAFLSRPTIQPARAVVQALSQRTFSSLPSLRPSITPLTSAFRRPNATPFTPSMVDAADVVPTSAITEHPALGAMQIRCGPRNTMNRNTRLIQKRRHGFLSRMNSKDGRKIIARRRAKGRKKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQA5</accession>
    <name>A0A1B7XQA5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_14521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150467.1">
        <property type="nucleotide sequence ID" value="XM_018309495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQA5"/>
    <dbReference type="GeneID" id="28873602"/>
    <dbReference type="KEGG" id="chig:CH63R_14521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14521"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR01949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="555" mass="63516" checksum="BE50259FD2BA23BB" modified="2016-11-02" version="1">MQSAEWPVPPQVLMPTALLIVYLVYNYLIFPTPHSIAKLRFLNGEPGEWAPHLRALYRNTLDLKKTLHLHHTQHKNETVRVPILGPGQNNLILLPSAERKWLVSQPDSVASMHEQTINHFQWDLGTIYPTRDHNEVTIHIVATKLTREMGNLIPALSEELELALAKHWGDEDDAASGGNEWKEVGVYDTLRPIVSQAINRIFIGETHCRDEEVLDTGFYYSKVIPLEANLLWLLPTPLRRLLAPLVTLPSRWCERKWFRLTIDEVRRRLEARGHRQHGKGSETGDWQHEGEADKHDLLSWFIAYGESQGDPYLLDPEVLSARILLLNAFALHTNVFAIMHMVLDIVGSGAEQGPKIVAQLRQEINEVRAAHGEDQGWNKRSLAQLERLDSSFRESQRINTILSLGPLRIVGKDGLTTPSGVRIPRGYQVGIPTYSIHFDTDIYGPDAEEFKPFRFYYRRKDARGTGDNLKGARQAWATTSADYLSFGAGLNSCPGRFFASGMLKVLMANILQRYDFEFQEKRPENLWFGTNHIPPMSAKIRIRRRRREFSEQTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRD5</accession>
    <name>A0A1B7XRD5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_13551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150843.1">
        <property type="nucleotide sequence ID" value="XM_018308525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRD5"/>
    <dbReference type="GeneID" id="28872632"/>
    <dbReference type="KEGG" id="chig:CH63R_13551"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13551"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="58380" checksum="940275FF7D2D9F60" modified="2016-11-02" version="1">MPSESRIENPFFHPFLFIFQIWQWFADKIFSPTPPEPSTRLSRPKIAVIGAGITGVTSAAHCIGHGFDVVIFEAGGRENLGGIWSRVNNSSSLQIHSMMFRFHPSVKWERGYPDRQQILSQVKQLWEKYGLETRTKFNTAVEKVYQDEKGRWVINNTANGHFEGVIAAVGTCGEPKMPQLPGLENFKGNVYHSSQLTGKNAKGKKMVVIGGGASAVEALEFAVDEEAEKTSILSRSDKWIIPRNPIVNMLLAMNILGQETRLSWIPETLLRKLFYRDLQEIAPYSKGIYMDTPMVNSQVMDTIRSGQAEWVRCDIEGFTADGVIVNRRAQGVPKGGPGRRQVIPADMVVMATGYKRPSLEFLPEDCFNDPYAPPNWYIQTFPPNHPSISAINCTYVAAIGTVGNWHIGIYTRILLMFLIDPMTRPHPFWMKAWIEMTKLLKSAAPTGAFDFFTYLELLWWFAFSVTFNPFRWKWAFFVFFGLGFMLPKRVVEVESRIRNGMGFQDEVGRDVGHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRZ6</accession>
    <name>A0A1B7XRZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151025.1">
        <property type="nucleotide sequence ID" value="XM_018308707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRZ6"/>
    <dbReference type="GeneID" id="28872814"/>
    <dbReference type="KEGG" id="chig:CH63R_13733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13733"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="390" mass="43982" checksum="59B2D175BF7D8E15" modified="2016-11-02" version="1">MADSSPAPATNGTAAPVATSPPAASPPGVTGTSAPLGNAADEPEALEAADTATDTDDDSSSVDDRISTYTASLTSSAVDYPTEYGRRYHAFRPGSYFMPNDEDEMDRLDLSHAITLRLLENRLYLAPLEKEKIHKILDIGTGTGIWAMEMGDFFPNAEVLFTPVSFLGIAFTKTRPGLRKRPERYPTRLFEIDDVESRWLDDRKYDFILCRYMVGAIQDWPKLVKNIFDNLNPGGWAEFMDVSGEYYSDDGTLTEEHATRKWNMTLLDGIVKMGRESRTGPKLEGWVRDAGFENMFHKKMKLPIGPWPKNQYHKDLGWMNLSQLLQGLEGFTMRVFTGVLDWTEEEVQVQLAQVRNELKNFHMFHSQFDIHVVYGQKPLVAETEETTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSI4</accession>
    <name>A0A1B7XSI4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151228.1">
        <property type="nucleotide sequence ID" value="XM_018308910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSI4"/>
    <dbReference type="GeneID" id="28873017"/>
    <dbReference type="KEGG" id="chig:CH63R_13936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13936"/>
    <dbReference type="OrthoDB" id="5402897at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="423" mass="45760" checksum="8F97286712B61275" modified="2016-11-02" version="1">MSSQQQPRPLSHLSPVPADKLFALYDNKKKTLSLSADGKAVHITTDIHFKRLPFLGGLLFELQGWVGPVTQGDQPYSVTDSFDVDLPSPALPSGNVVVRTANNKRWVVEIEGLGLKKTQPSSKDAVDLQVPETRLVPPPEPIITGLGQTFTIKQADKFTGEGGSVNISFNDDFVSLKDAGIQENDKIQWTFTSHQTGNTEVVVFVGQTNPPFEYRVPYHVTIVPSNEASNANLKASALFSVAEVPANGTNGSTNGAQKNGAEAVGLPLSWDGVVNVGLNLIKKQYSDAVLYVVDAKPATTKPVLNEWGLSKIRIITRIGGNKTAIIESTGWGQFGQIEVLPHPLLGNSSIPWPLSLNIHEAFAILRKAGYQEPVYSVALRQPVTATADQPFYIFNIGNQSIAVGVDDRKVQDFGPTGQENQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSM4</accession>
    <name>A0A1B7XSM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151252.1">
        <property type="nucleotide sequence ID" value="XM_018308934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSM4"/>
    <dbReference type="GeneID" id="28873041"/>
    <dbReference type="KEGG" id="chig:CH63R_13960"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13960"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="414" mass="46437" checksum="2EA6AFB21DCD5895" modified="2016-11-02" version="1">MCAGIFVPNPFVIERRKNRTTRLACRPRTPSQLVQSFRQTEKPRRSVLSAEISSDQISNMSVPETSHAPAFLEAEPSLNTDADSATTSADEASDGESAGNDESDLDSSLGAEVQPSTMSLRSSILRYREENGRTYHAYKDGAYLMPNDDLELDRLDLQHNLFLLTMGNKLFLSPLDHEKPPQRVLDIGTGTGIWAIDFADDNPASTVIGVDLSPVQPSYVPPNAYFQIEDIEEEPWSFSQKFDFVHSRMNTGGIRDIPKLFRQAYDNLNPGGWIETTDGALATSDDGTLKEDSALYQWNLLLSKGTEVLGTPYGAAPTYKELLREAGFINVKEVIFKWPTNQWARHPRHKELGTWNYENVLMGLEGLCIAIFSRVLGWSKEKVDVFLAEVRNDLKNRDIHAYWPIYVVCGQKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSQ3</accession>
    <name>A0A1B7XSQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pentatricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_14006</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151298.1">
        <property type="nucleotide sequence ID" value="XM_018308980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSQ3"/>
    <dbReference type="GeneID" id="28873087"/>
    <dbReference type="KEGG" id="chig:CH63R_14006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14006"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="813" mass="88856" checksum="5EAFFE22D4A685A6" modified="2016-11-02" version="1">MVRSAASPRTVDDLAPTDASCPQQSAPFVSCYDPLTLPSQLPLGLLNAAQGHPMLVELKNGETLNGHLVMCDTWMNLTLKEVVQTSPEGDKFVKIPEVYVKGNNIKYLRVPDDIIDVVKENQANHQQGGFRGGRGGNRGDHGGRGGGGDRGRGRGQGRGGRGRELPPPDTKLFPSIPPARPPTCTLGFMSGSRAVFDGLWRCLCPSADAYVAARLLNSPSLPRASIATSHRRRPVPSSRGPAIRTQCRRHATTAASAPRSEGNTALADDDGAPTDDTAWSEAQQDTAPTEADAPDPNEQLRAAPLSAIYDALRVLKGQPKSFDKVATFITHLAQYRKAELSPQLYEHLIVATSDVKGSAAMLAQLFAEMKQLQIKPTISICHAALAVLAVHPDYLVRNEVITALKQSWSEVSVDGQSHIALGLLRDGQLEMALDALESMMDKQVAIPSWVYDIFIFIFAQHGFVDEAIKLAHGKAHAGSEVKLAVWYMLLDTCALAYHYEGTKYIWGRLLDTDREHLSDGVLLNVMNTATRQHDFELATSAARLVTQRGSKLFAHHYEALIECYGGAGDMASALRVLCIMFRAISVAPYASTRSIYSWIRKHPESIDSALQTLTELVPNYKVPIAALNVLIEAAVDCHGYAKALEIYKNAHKYTEAAPNHVTIRYVLQACDDLESLKALVAENPELALKGDPGVFGKAVYEYAVAGDLDLAYRCVALYGEAPAASAEEEEKPSNAEPWIPKKTLLTLVRKSLDVQDERVWWLIEQAERRNMDVQSGISKLMASFAEEIKRSTGLAQEDRTFTEGLEPQHHSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XST5</accession>
    <name>A0A1B7XST5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151333.1">
        <property type="nucleotide sequence ID" value="XM_018309015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XST5"/>
    <dbReference type="GeneID" id="28873122"/>
    <dbReference type="KEGG" id="chig:CH63R_14041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14041"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7793" checksum="50D243A3BABAFA87" modified="2016-11-02" version="1">MDTLSRRRGNIWEDEMTWSAFLRTELVRILIFVQLDHGNFAMQAGKQKKKKKKISPNKKKPKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUC6</accession>
    <name>A0A1B7XUC6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nudix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151900.1">
        <property type="nucleotide sequence ID" value="XM_018307483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUC6"/>
    <dbReference type="GeneID" id="28871590"/>
    <dbReference type="KEGG" id="chig:CH63R_12509"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12509"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601091" evidence="2">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="18773" checksum="F0776B0DB2CDD6A0" modified="2016-11-02" version="1">MHLSLLWLTLGLALIVGANPVNPGSPKSEKPGSSKPVKSGSINEGDSRLRCGVVAFEPNGHVWMVASKKDGYILPKGGFDEDKDKDLEDCVVREAKEEAGVVVDRDSIESLDDVKDGSVHWFKCTALSHGARTDPELAKRKPPKAYSVAKAWKRLKEGYLSRRSGDAICALES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV31</accession>
    <name>A0A1B7XV31_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Uracil-5-)-methyltransferase TRM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152134.1">
        <property type="nucleotide sequence ID" value="XM_018307717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV31"/>
    <dbReference type="GeneID" id="28871824"/>
    <dbReference type="KEGG" id="chig:CH63R_12743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12743"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="317" mass="34234" checksum="9BECEB5186666963" modified="2016-11-02" version="1">MTVSSGPQHGAGHPAVPAAVDDTTTADLTSPRQPAKEEEEEEEEDAAAYESRHVHTVYEAIAPHFSSTRYKPWPLVASFLLSLTPGSVGLDAGCGNGKYIGVNPALYIVASDRSANLVSLARSYQPPHFDAEVSAAAAVSKKKNKKSKGVAATSGPAADAAQTPPLPPPPPPARAPNNQVLVADSLALPYRASAFDFAISIAVIHHMSTRQRRRAAVAALLDAVRPGTGKVLVMVWALEQGSSRRGWDAGAAQDQLVSWVTKGKKEQDRPAQDETFQRYYHLYREGELEEDVVEVGGRVLERGYERDNWWAVFCRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVK0</accession>
    <name>A0A1B7XVK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CAP20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152281.1">
        <property type="nucleotide sequence ID" value="XM_018307864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVK0"/>
    <dbReference type="GeneID" id="28871971"/>
    <dbReference type="KEGG" id="chig:CH63R_12890"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12890"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="183" mass="20281" checksum="ECF4BF19D94CE92F" modified="2016-11-02" version="1">MPKMAQVNGDLPSVNSAAIQHLLDYPAVHDSVVTFRNNPYGKKSVALTESVYKTFAEPLLPFFARPWGYLRPYAEKADNLGDQALSAIDERFPVVKKPTEELYAGAKGIVALPFRTGFEAKDHVLKTYSQEKKKVGNENVVAFGKAVVSTALITTSELIIWVGDVIHYKKEEAKEVANEKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVW6</accession>
    <name>A0A1B7XVW6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152406.1">
        <property type="nucleotide sequence ID" value="XM_018307989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVW6"/>
    <dbReference type="GeneID" id="28872096"/>
    <dbReference type="KEGG" id="chig:CH63R_13015"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13015"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="130" mass="14581" checksum="3A19997733AB95D9" modified="2016-11-02" version="1">MAPSHVSVACKSFRYTEVGCRLGEEERENGCGKFWRIVIHGGGSARITTRTNQDKVIVVKPRFCGDEPCLLYVASCRTLSEFREACYEVVGQMCRVVKTSGLIKYSSIKHLSFVRRLPSGSGRPLLRVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXC0</accession>
    <name>A0A1B7XXC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_11102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152917.1">
        <property type="nucleotide sequence ID" value="XM_018306076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXC0"/>
    <dbReference type="GeneID" id="28870183"/>
    <dbReference type="KEGG" id="chig:CH63R_11102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11102"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="722" mass="80652" checksum="CDDD1D49B0701DAF" modified="2016-11-02" version="1">MLQSSSERAAAHPKRRYTSKACEECRRRRAKLTRPGTTQCDGQRPACTRCSERSINCLYRSEEDGRKPASKSYVQLLRSRIDLLEAVLQSRAIDIEASVAQLSTTGAMPQLPSITNPLAGGSDAGLSPSAFDDLCATFEGALSLDEAVNYDQDGEMRYFGPSSGRLEFQSESTPDNEDHESSPATTKSVETNRFILPLEAEVYPEDLQTELIDLFFEYQSPWCQVVNERLFRESMKTQGRFYSPLLLNCILALGSRYSDRIDTRSDPADQNTAGKPFMQKAEVLLHYDMKHPTITTLQSMSILVGVYVSYGCDAAGWLHQGMANRLALDMGLNLDAASLVGTCHMSPEEIELRRQVYWSLYCDDKLAAIYTGRVCSLLDVQGAVNLPSPLTPEQISSGSNDTTEMERCNKKILVHRGLIGLCRILENILLALYAPKPLYKGPQRISFLQSCTLELKTWFYELPADLRIDKHNDLPQVYTLHMVYHTCCILLFKPFLIKPKDAPVVPKTDTAKRAEEFCIESAKRICHAGKKYRQVFGSFRRSPISATHCILTATLVLIQYASPDPDFANTGRPCCTLYIEACLEILKELSTSWKPACRTRANLIKYLYQKYPERIPNSLLHDERRNTAVAPEKGVEMLAAQPQESLEQNLCPLMNMVDQNFAWDGVGEGSQGFGGGGSESAFNTQFALADSIMNGGGQDGTTFMDDAFWSGVNFDFNYDPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXP0</accession>
    <name>A0A1B7XXP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153033.1">
        <property type="nucleotide sequence ID" value="XM_018306192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXP0"/>
    <dbReference type="GeneID" id="28870299"/>
    <dbReference type="KEGG" id="chig:CH63R_11218"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11218"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601158" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="266" mass="28440" checksum="0DEC0008AEC6F2EE" modified="2016-11-02" version="1">MLSKSIVVALLGLASLVTAERKGPVADVPLIAHTGTPVGKEVSYNGLTQYVSKPKKWSAHGNKTTGVLYLTDVFGIQLDQNKLLTDSFARAGFVSVAPDLFNGNPAPNDINIPGFNTTQFLAQHGPNVTDPIVANSIRYLREELGVDRVAVTGYCFGGRYAFRVLADGKGADVGFAAHPSLLSDDEIKAITRPASVAAAETDNLMSPARRAEVEALLSQTGQPFTVALYSGTSHGFGVRANVSDPRQKFGKEEAFLQAVRFFDVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXX7</accession>
    <name>A0A1B7XXX7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153145.1">
        <property type="nucleotide sequence ID" value="XM_018306304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXX7"/>
    <dbReference type="GeneID" id="28870411"/>
    <dbReference type="KEGG" id="chig:CH63R_11330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11330"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601161" evidence="3">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="60266" checksum="AC69BA57358DFA2A" modified="2016-11-02" version="1">MRRSPFLAPLALAGAVGSASAASLPSPSCKYLPGDPGWPSADAWAQLNRTVDGRLVATVPLGSACHGDGYNATECARLQDAWLYSEVHMESSSSVMAPLFANASCDPFTPRDVPCALGNYVSYAVDASGPADVQAALRFADQHNVRLVVRNTGHDYNGRSTGAGALAVWTHHLKGAEIIDWDDGSYYVGKALRAGAGVQGFEAIAAADAAGLAVVTGECPTVGIAGGYVQGGGHSALSTVYGLAADNTLSFEVVTPTGDLVTASRTQNEDLYWALSGGGGGNYGVVTSITTKAHPDAPVSGATFAVTIPEGDNNETLYRVIDAFHAALPDIVDAGVMIIYFFGPGFLQSPALTAYNKTRADVERILAPLVGSLAQLNVTLEPTYTSFDTYRGHYNHYWGPLPSGNIQVGTQLFGGRLLPRAVLPSFGPTARRLVELGVTYIGVGLDVSRFGRDGANAVLPQWRDSIVQVSLTLPWSFEAPFADMLAEQDRMTEVVQPVIEAATPGAGAYINEADFQQKDWQETFFGANYPRLLRVKNKYDPAGLLYNVAAVGSDAWNVDYHGRMCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYA3</accession>
    <name>A0A1B7XYA3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_11433</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153248.1">
        <property type="nucleotide sequence ID" value="XM_018306407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYA3"/>
    <dbReference type="GeneID" id="28870514"/>
    <dbReference type="KEGG" id="chig:CH63R_11433"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11433"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="504"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR04730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="763" mass="85264" checksum="893340B6D0ED5EFA" modified="2016-11-02" version="1">MTSSSDEGEIMEHDAVELKATSLPKKFEGNGVDRQDRTRDRYSASKSPVHDNAARHHNPPRRSRSPPPRGFKRARDERDYAASGRQDTRRFRVHYEDGPRDDYRRSRVSYEDLDRPPSRGSNHSQDGRDRNWSRDGERDTYRERDRYPDKRPRNRTRSPYRPPRNDRGGRDNYYSRDGGRDRLADSFRDLKYDEQRDRDSRNGGTGSNGAAVGKDSRASRDDAKPVKNSADDRNSAASRSRDQTSVSPYSKRTRFLLTPEGSAPQVVEPEHGYDEPEEPVVIDEEAEIERRRRRRDELLAKSNSATPLLVHALHAADKSAVSSPAQEGTPGTPVAGDVGTPGTDFESPARDGSSPGAIDIVNESDLMNTHGGGEVTEEDGPSAADYDPTVDMKEDERRDEMRHGNVGVHGEAPDAQTEAEPQKPPQEAPAKKPSGADEDDGDFDMFAEDFDDEKYAAPNPAQVAVVDESKASPALAPPNGAILEGDDKDGYYKIRIGEIMNGRYQVQSTLGKGMFSGVARAVDVTNKKLVAIKIMRNNDALRKGGFTEIAILQKLNDADPDNRKHIVKFERHFDHKGHLCMAFEHLSLNLREVLKKFGNNVGINLGATRAYAHQIFIGLAHMRKCSIIHADLKPDNILVNENRSVLKICDLGTGIDKSDAATAHNEITPYLVSRFYRAPEVILGMPYDYSIDMWSIGCTLYELYTGKILFAGDSNNQMLKAIMEIRGKITPKLYKRGQLAAMHFDELGNFVSMERDKALGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYD7</accession>
    <name>A0A1B7XYD7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153306.1">
        <property type="nucleotide sequence ID" value="XM_018306465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYD7"/>
    <dbReference type="GeneID" id="28870572"/>
    <dbReference type="KEGG" id="chig:CH63R_11491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11491"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="416" mass="45069" checksum="6C1E8FC990FAA7DE" modified="2016-11-02" version="1">METVLRNACDACHKLKTKCPSEGAGACANCRRKGQICKYSPRSEMGRPRATAPEKSPAQKQQSGKRSASVQDASPRKRRQSSADSASGIPKAAPASPERGRLQQIDDVGTELMGQPVVGNGTTEPLGMSDYLSTLETSLCSFPFQSDSFIPDDSAFDISWPTAAPPPYSSHSPVPLAAIHDPAGQMAPINLFFEDSSDTSSSGNLSFQPDAEFGVATMNGMHGIGLAQEKQQGVVGSRESTPDDGSDALIEAYPQLASVLFGLHTYYDKCKATPDLPALMGSLEEVFPLVSSLCDILRGPQLNHLLNNRSNLTSPCFLLAGSVISTVVETYHLRMGPFEPSGAERDRTAELGTQYRLQLQTDATIMEFHLSELRPILNKIHVGFRESQTIELMDAMRRTLREFLENWRARNGGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ71</accession>
    <name>A0A1B7XZ71_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153596.1">
        <property type="nucleotide sequence ID" value="XM_018306755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ71"/>
    <dbReference type="GeneID" id="28870862"/>
    <dbReference type="KEGG" id="chig:CH63R_11781"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11781"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="121" mass="12740" checksum="0B3319FD0B1C5E9B" modified="2016-11-02" version="1">MQFEPAEPNTGALSSIELQTMLAAALPPAPLLSGPTPRTGSKQTGHGPIPRDLREADATPAKQPSPEGEVRPATGSHRLHAFSSAAWSHHVHSARSVHWLSVASMGAQSTTQSRQIIGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZD3</accession>
    <name>A0A1B7XZD3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153651.1">
        <property type="nucleotide sequence ID" value="XM_018306810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZD3"/>
    <dbReference type="GeneID" id="28870917"/>
    <dbReference type="KEGG" id="chig:CH63R_11836"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11836"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="38481" checksum="4CD1C7A5AE3E2DAF" modified="2016-11-02" version="1">MGLRQNPIPRAKGILGRLWPRVPGRPRLGVMEQPRTKQFVMFSVEGKPDTPKCMTIMFWPILKQVPMRVNEPMLIWKRLFKTSLRKLSKKTQARQLRNPRPALNPPLGTATPAISATQVVRPLCDYLHCQSSGPQQHLRDRTGKSIVGDSFHVPVLRWPTRYLPTYLTTGCFAPAIGRPKLNLALALLDSQPLDINGATSPDGHLIALRRFLSHIPLSSLLPVYFHLPELTDPLHAVLPSHPPSAPAVTAAPETIVESRTNKERSAGIAVHCKSEPASDPDLSLATIHLQFLSSTLTQAAFPAEEPFRLQSSTAPTGGAPSIVPHARDVSNRYAQSVQPLLQKQTHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZT1</accession>
    <name>A0A1B7XZT1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EC65 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153795.1">
        <property type="nucleotide sequence ID" value="XM_018306954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZT1"/>
    <dbReference type="GeneID" id="28871061"/>
    <dbReference type="KEGG" id="chig:CH63R_11980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11980"/>
    <dbReference type="OrthoDB" id="4829673at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601215" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="15078" checksum="457C57750B9FF4D1" modified="2016-11-02" version="1">MKLPSVFLIVTLALTSVEACASYKHCWCLRNDIEYQGKIQSNIAWDDDTTKACQANGGGGVTGYYGQNFKECYRYVKRTWRLDGAIDNCDWNKVSEAQKAGERDDANRLVKHCIAAGKAAGVNAYGVCRDKISGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0B0</accession>
    <name>A0A1B7Y0B0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153965.1">
        <property type="nucleotide sequence ID" value="XM_018307124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0B0"/>
    <dbReference type="GeneID" id="28871231"/>
    <dbReference type="KEGG" id="chig:CH63R_12150"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12150"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="7576" checksum="EB953522F94BDAE4" modified="2016-11-02" version="1">MDEMVLAGIVMFQYEKKNLKRPPTIDTGAKYVDSHLFTPAPSPPAAPFGAPFSQLRPMAEKNVIKEGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1R0</accession>
    <name>A0A1B7Y1R0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154461.1">
        <property type="nucleotide sequence ID" value="XM_018305037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1R0"/>
    <dbReference type="GeneID" id="28869144"/>
    <dbReference type="KEGG" id="chig:CH63R_10063"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10063"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="720"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="845"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109630" checksum="D809F93A7E71E4BE" modified="2016-11-02" version="1">MNATPTNRLKLTPGNSPYLQRPTSRTPLRGRLPHESRLSLKRVIGTTCASPTGFDTVNSSFAYIAGGAVVVVDVDGEHYAQRFYRARPTATPVYGSASLSNNYSAPSTPKANDSRNRVAAGIRESQSWSDSPSSTWTSRERIKAATCLALSRDGRYLAVGETGYAPRVLIFNLEDASSDVPLVSLSEHGFGVRVVAWSSDTRWLASLGTSNDGFLFIWRIDPRTGAAKLYQQNRCTSTIKGMVWMGNSLVTLGVRHIKIWRVEEPQSTSPSKSRFNEANSTPQPPQRLLNGRNVLLGSLLEASFSCAAVVDETNIIICSEAGDVCMVEDDGKQTRLIKCLNVDFPITSITIRHATAYLSGKAGQVATLNVRAVLDSLPDSVLSQSVAPSGLVAMGFLTENLVTIDEKHTVDIWSSSYLPGKNEEDPSHVSIPGHGDQILGIQTLAKPNDQGADFFTWSGSGKVIFWDMKGRIKCSLDVPIEQAIPENEMDPVNQLNVVRATRAGKMLVAADKFGVLRIMDLSTKECLLETKAHSSDCQDITIYEDDNKFLLATCGRDRTVQLFHRSSTGEFRHYQTLEFAARVVQTLIPAEDKIITCSLDRTLQVYDIVCKEDDVDEIAALPSRTNILKAAPTSFALGLDDRTAFVSMLDRSVCQYDLSNGKLLNCFKCVDEGGYETAIMDSLIFSQPSGKDSGVLLGVSNTDKSVRLYDAHSGQFVDREWGHTEAINGVTLTDDDDGSQRVISVGSDGTVMLWGIEGEDAAPSSISRDPSPMKDGSAAARPPLRRVLSKAELAEFQRPSSAQGGRRSPPRTIRRRTSRYGLSNSVSTPKTAMQSSPLAEDTPSRRSSGSQSGSPPISPKSRTSRRPSLPSLGLPPKKSSPNLRGFGSLNMATEQTCRSLRAYRKKLSSADPLSEDVIFELEQELRLTAAALGERATRTKAMHDTALLSGLLDQYEERLASMLDEKLRNTFQAREVTTPSEEREEVLLSQRPGTAGGETNSTVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1U6</accession>
    <name>A0A1B7Y1U6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf726 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154497.1">
        <property type="nucleotide sequence ID" value="XM_018305073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1U6"/>
    <dbReference type="GeneID" id="28869180"/>
    <dbReference type="KEGG" id="chig:CH63R_10099"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10099"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="839" mass="91783" checksum="D431F7C3A08BFC15" modified="2016-11-02" version="1">METTQGSSPSPAAPASRQVSVVQETATGVPPQNRPHNTNTDTPPASSSHPPVPDPNPNPTPGSTSERYINTYLSENDENQYNYSYSDEENLDTSSICSFEEEEDGNWERDPDEDAMAGSRRPHNQRRRTQTDLTGVLTIDEKDELISLVSNILDSMQDQISNIFHSPPITPATTEDPQHSWLSLSLLKNKASAISQSQSTANKENTRPSSSSAQQDAGKTYKKAHDIVEKEEKEAMTPQLQELKKECLVVFQKWQGNVLTRAKDISVKDPEASSAGPAGRGGRGGRGTRGGRGDRGTPQGGRGTPRGRGGRGGPLSVKTGAARQPSEVDPWLARRFPPTATPLASLPVERRKLLLHTVLLLLLSLEQYTSFSRVFMLKLTSSLHLTLRMFQEDEVRVARGLGKTVQEVNADEVVEDKSAENKSSRRWKVGLAGAAGAAVIGITGGLAAPLVAAGIGSVMGGVGLGSTAAAGLLGTLAQSGVVVGSLFGIYGARQTSKMMDQYARDVADFAFLPLHGEMKEEYRDAKEIAPKDRRLRVVLALSGWLTQKEDVINPWRCIGHQGEVYAVRWEVANLMNMGNSLETVIKSTAWSVAKKEIVTRTIFASLMSAMWPIGLLKVSKVIDNPWSVGMVRAEKVGMILAEAISRKVQGDRPVSLIGYSLAARAIYTCLMVLAERRQFGLIESVVMIGTPAPSESRVWLALKSVVAGRLVNVYSENDYILGFLYRTSNLQFGVAGLQPIQGAEGVENYDVSSMVSGHLRYQYMVGTILKNIGWEDLDYAQVEKDERVLGLMDEKYGRDKSQKPAYVDMDKEAEHIQEEVKHKNDSKLDTRMSKMKIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2A3</accession>
    <name>A0A1B7Y2A3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154625.1">
        <property type="nucleotide sequence ID" value="XM_018305201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2A3"/>
    <dbReference type="GeneID" id="28869308"/>
    <dbReference type="KEGG" id="chig:CH63R_10227"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10227"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="77" mass="8269" checksum="1ABA3A64581F8BC0" modified="2016-11-02" version="1">MAGVANGILDNSISSGDERTKRPVDSSKPPRRKTEGDAAAPEFNPVQSSPVQSVMEQFHQSLWIEGTGMCLGSIPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2W7</accession>
    <name>A0A1B7Y2W7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylesterase monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154867.1">
        <property type="nucleotide sequence ID" value="XM_018305443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2W7"/>
    <dbReference type="GeneID" id="28869550"/>
    <dbReference type="KEGG" id="chig:CH63R_10469"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10469"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="118"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="37409" checksum="7478B38102904BE8" modified="2016-11-02" version="1">MSPGLSLLGGVIVGILSILYYANQPAAPEMTGLQFDAEFWAAAGPLIAVRPPKRPTDALELRASVNTGLSAILKHALPDGIVETRHQVKSFDGQTIALYHFAPPPKADETNGTQPAFIYVHGGGIVGGDVDPYSRPLAAKAAQETGVSMFAVEYRLAPEFPYPTPVEDCYAALAWLSLHAKSLNVDPARIGFYALSAGGGIAAGAALMARDRRLSPPLAKQILIYPMLDDRTRVLPENPLSQFLTWTDASNRIGWTAYLGEGKVGGPDVPSYAAPARATDVAGLPPTYIDVGGVDLFCAEAVAFAGRLAAANVPLEMHVYPGLPHIFDLYAPAIELTRRAKENRLRAVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3B5</accession>
    <name>A0A1B7Y3B5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155001.1">
        <property type="nucleotide sequence ID" value="XM_018305577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3B5"/>
    <dbReference type="GeneID" id="28869684"/>
    <dbReference type="KEGG" id="chig:CH63R_10603"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10603"/>
    <dbReference type="OrthoDB" id="4809754at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="304" mass="33415" checksum="912831D5046D2535" modified="2016-11-02" version="1">MDSPALLLYRTARVAVRQPHEALVTTEGEEPEVLYITQDGIIGGTGQVSVYLMQPKMTSVRAEIIRRSAHPVCNYIWKVKTDCWKLQVKFTSPWQAFAQLAWFPSPEGSRCTAAASFSRSPGEVVVRMGPSGRAVGKATQTLIASYGSPTTYSIDINHITKDDLIVIFQPDDPTLAPVLSQACTRSPVEWKTEAVQPAPDYSNDTFSMSSQIDTVYTTEAECQMDLCFPLRRSGVSLFELQAGQQSCVSGQYQSPYTDESSPASESTLDIRADDGLSARFATMYKGGTQQEDNDDQCIVVKLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3S6</accession>
    <name>A0A1B7Y3S6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155161.1">
        <property type="nucleotide sequence ID" value="XM_018305737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3S6"/>
    <dbReference type="GeneID" id="28869844"/>
    <dbReference type="KEGG" id="chig:CH63R_10763"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10763"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="104" mass="11550" checksum="8A42BCBEC7CF3556" modified="2016-11-02" version="1">MGNLIRDPRTSKDHGGDRLETMELLTLSLVCIRPRRRAGTKDQGPRTDNNGLLGHGRRTPQIKSISYSQDVYPKGDVETEAASDDNRMPNRRMEAIGSVLCTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5D8</accession>
    <name>A0A1B7Y5D8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155758.1">
        <property type="nucleotide sequence ID" value="XM_018303735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5D8"/>
    <dbReference type="GeneID" id="28867842"/>
    <dbReference type="KEGG" id="chig:CH63R_08761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08761"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="266" mass="28466" checksum="6B47D85FFE67005A" modified="2016-11-02" version="1">MSESKTGSRLAGKVVIITGGGHGFGEGIARKFAQEGAKVLITDINEDDGQRVARDVPDSISFFKADVTSAEDWEELMDAAQSRYGRIDCLINNAGTTYRNKVRAADHTTRPTLEVTEAEFDRVFNVNVKGIFLGTAAFMPRVIKQGEGGVMLNIASIGAVRPRPGLVWYNASKGAVCTATKGLAAEYGAHQIRVNSVCPLLSGTGLFESFAGQADTPENRSKFTDNVPLRRLCEAADVADACLFLASDESKFITGINLEVDGGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5M6</accession>
    <name>A0A1B7Y5M6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_08861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155858.1">
        <property type="nucleotide sequence ID" value="XM_018303835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5M6"/>
    <dbReference type="GeneID" id="28867942"/>
    <dbReference type="KEGG" id="chig:CH63R_08861"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08861"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="64"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="162"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="494" mass="54302" checksum="89082FBC2B4702E5" modified="2016-11-02" version="1">MSEKKILVLGSGLVAKPCVEYLLRNEKNKLTIGINPVLTHTHSLSLSLFLSKLLFLAANIPNTACRTLSTAQTLASNHPQATAIALDVASTELDAHVATHDLVISLVPFVHHPTVINAGIRGKTHVVTTSYVSQTIRELESEVEAAGITVLNEDLTYSNSLGVDHLYAIKTIDEVHRKGGKASIHSLLKEIKEFHSYCGGLPAPECADNPLRFKFSWSPRGALLSQVNAASYLQDGEVIKVPNRDLMAQAKPYHVVDGYSFVAYPNRDSVPFRRFYGIPEAKTVVRGSLRYEGNPAFVAALVKLGWLDARPRSWLAEEGGELTLREVFGRAIGAAEMNEESLVSRIDELCGFSDDEERHRIIDGLRWIGLFSDKPAALRGNLLDTLCVELERLMSFQPGERDLVMLQHRFVVEWRGGRRETITSTLELLGDPDGHSAMARSVGVTCGIAAQLLLDGEPALNVRGVLAPYSAEICDPIRKKLEEEGIKLVEKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6R1</accession>
    <name>A0A1B7Y6R1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156219.1">
        <property type="nucleotide sequence ID" value="XM_018304196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6R1"/>
    <dbReference type="GeneID" id="28868303"/>
    <dbReference type="KEGG" id="chig:CH63R_09222"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09222"/>
    <dbReference type="OrthoDB" id="3522308at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="626" mass="70936" checksum="C4EC76F3F04C3EBB" modified="2016-11-02" version="1">MSRQIQRLDVTPPSEDSDAVNSGSRYAGRLSTSSSHLSPVDSPPRAHRACEKCTRTKKKCDKGLPACSRCTRLTTNCCYDFVVNPPSLTIVDQGAVATAYKHPSDARPTFEWLNQVDFTAGQIMQLLVSHGVDWKASVNTYFNTVNTWLVVIHPDAWRRRCAAADLDTNPNDSDLAMLILCIHLLTIWNCDEFSSTAMLDHPLYQTAKRIWTLRKAFSKAKIEHVQCGVLISLYEMGHGDITRCYQTFGEAASLGKVLNLKPGKYVKEEEDMPADPEDEQNRALWWVLVIMDKISHEQSSTLWNPLQMDMPSDDDLLPTEHYLWDSDRNGSFKLVKRYPVTIPASVRVGAFQRSCQAAILLGYAINWEAANAELDEPPSVWSFVQLESATRDLIEALITRSETWGENLNTYAQCARFVSIPACQRPVPQALTSPSIFCLLFYSFLYAANRPDTPAQDPETDVEMRKAVAGIKFTIGLVIDGSNGIFNAYSSRDDVLEHCAPVWPYAQYHTMQLLFHYEALLEDAESMMAEVRHRVDCTTKRWACSRGEEERGQDVQKVHNWKQDLRALPSSRMRRRHIRRRGSLFVTMQKRITLDSKSQQDRPLDPGVYDPVRLGLSAYQDGDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Y4</accession>
    <name>A0A1B7Y6Y4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_09245</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156242.1">
        <property type="nucleotide sequence ID" value="XM_018304219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Y4"/>
    <dbReference type="GeneID" id="28868326"/>
    <dbReference type="KEGG" id="chig:CH63R_09245"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09245"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="13">
        <location>
            <begin position="324"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="52772" checksum="E2460936CAFBF087" modified="2016-11-02" version="1">MLIGICGGICSGKKTVAQYLVEHHGFKLLRLEDPSSPPPRNESPTYTAYSETPAYNEPPVSQPQSTPRSPAPEPAPSTAGHDDWDSQPQPPKKKGKKKKTAGLQCFVCKQEGHTKTECPLRAQDTTAVAVNGNGNGNSNGNVTRVDESPARDYTPPMIVGAYAMVTRPSRPPQPPHANNSFHAPAPGGQAPASSRQQQQQLTFSSADALVDFVTTRWQSRFVTTDVHNEAVLDTLSRRPFFMLISVDGPLTVRHARFRALHNPHCTLESFARASDNHLYDPDHGMQPLISRATVRLLNTSSSLAHLYATLGKLQLADPVRLRPSWDAYFMSLAELASLRSNCMKRRVGAVLVGREKRVISTGYNGTPRGLRNCSDGGCARCNSGNSSGVGLATCLCIHAEENALLEAGRERIREGAIIYCDTCPCLTCSIKICQVGIEEVVYAHGYSMDSETAAVFAQAGVKLRQYIPAPNGLIHLENLENLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7T8</accession>
    <name>A0A1B7Y7T8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156572.1">
        <property type="nucleotide sequence ID" value="XM_018304549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7T8"/>
    <dbReference type="GeneID" id="28868656"/>
    <dbReference type="KEGG" id="chig:CH63R_09575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09575"/>
    <dbReference type="OrthoDB" id="10455396at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="216" mass="23923" checksum="F373929A4F68DCD1" modified="2016-11-02" version="1">MPKTTAERAVHLKTILKRRKNLKALARSYTAHPSRATFSTQLTSMAEFERYQFRQTALAGVMSSLHDAHGSALLAALDVQAETERQMELNGLDAALRKQVNGFVAALDAFTSAVPSPATSLPALCQRRIRNLACMRENALLADEEWGDLAESKTDASRDNVRCRYLDCCVLLLVLRYAAAKFRDEAKGCALDALQVAKLQGSNEAHLHAERLLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y877</accession>
    <name>A0A1B7Y877_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156757.1">
        <property type="nucleotide sequence ID" value="XM_018301979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y877"/>
    <dbReference type="GeneID" id="28866086"/>
    <dbReference type="KEGG" id="chig:CH63R_07004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07004"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="525" mass="57514" checksum="5B8403903A9CC85E" modified="2016-11-02" version="1">MGDPADGRERVSKVDAVDIDESDAGPAGGLVCPEGAAEAADDGADDEEQTAEGGGFGRPCRYHPNLQIELLENLDAAFGGHEADVLGVEERDTLLAGELLAVDGLVEKDLSLDAAILGGLRRLMSGIWSFHESQPTSFLDMSVSKCDLFPDEKTLGTIFSGVDLKPADCNIISHTFDTCTFSIHPEAAALPGHPKDLLVRLEASSGRGLHQLAAIQKLAQAQLPDLVPHVVVVGTTTTEDGRRVEYAVSEYFTGTIPLEEVWDALGPDDQMHLVDSVASAVEKLQMIDHDIHEAGTQPGHAPIGGPRSGDFPEIKHLLRGILQESEPMSRNYTLREVDGGGVILESAFADIGRAELTNADLDELKRHVVFCHNDLEPRNILVRPRLAEGTSPCYDLAAIVDWEMAGFYPFAYEYGLKDNVLGLSNLSLSWYFLFKKRTSRLLPHNQCHSKLIQALRVISQSKRRSMTRNVGVRFQEKWVAAHSLKPSLDIRRGWVRKADIKAPVNFTKADNENLELEVLRELGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8Q4</accession>
    <name>A0A1B7Y8Q4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156846.1">
        <property type="nucleotide sequence ID" value="XM_018302068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8Q4"/>
    <dbReference type="GeneID" id="28866175"/>
    <dbReference type="KEGG" id="chig:CH63R_07093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07093"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="727" mass="79118" checksum="800FE57E2BDC63CB" modified="2016-11-02" version="1">MQSSNSKFGGKIPKACEPCRRRKVKCSGHKPCRQCENKPSDCAYRLKPRVRLSTKRATPAPPLPVNAETAASGNGAVVGTPGSDHAGRRDDHAAAAASHRSAEEEERHHQHVAQTEVYHSVAAAHHAPKSTDSSQLFYGPSSNSAFLQQIHRGLLSAGHQYGQNHARDVQEGGPGLDMFMQRNIFFGMPLKINLEQQPAQPAAACCPVSPAQAAEFVRQFKNTHLATLPFFTPCELDEMLPALFVRHGADTPAAAAAVQPQRRTVFLAALALGALSTPQTDAAESLFVHARREAVVYEDAVTLPMIQFSILMAHYQLSMGRPNSAYLHNGTACRKALAMGLHAGTTGAISRKEEVQGRLVTLWSLYFLEIWLSLVVGRRSMMKKSDFDSCPYPDGQPTLMALCQFASVIEETIESIYDRRTDSLRQLYGKAEKLHGQLRQYGDKWSLGSSASVQRGDAWNAETSLLLHNIYFHVILIIFRPFLIAEAALQSGQGSVGVGDIWLRQACRHATDAAQDALAFTHNMLRGPEECKTRRYLAFFIESSCAVLLYDSLRHPSKHPHNLEFIQTAVSCLRALVGDEPVTNAIRSIKRIVWAVEQSIDASKSTASLMDAASSADSSPAWIPDNHRFPTNIQFPSLEENRGGAAGAAGAAGSGTGGAATASDDLIFFSNRASYRPQQPEEPLADYAMPSMPGAVNPFSDLNFDVLTTDLFNFFPVDMSAAPSGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y973</accession>
    <name>A0A1B7Y973_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157159.1">
        <property type="nucleotide sequence ID" value="XM_018302381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y973"/>
    <dbReference type="GeneID" id="28866488"/>
    <dbReference type="KEGG" id="chig:CH63R_07406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07406"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="559" mass="59544" checksum="6ABE0A49866FE1A9" modified="2016-11-02" version="1">MAANGDSRPTPGDRTVIGITFGNSNSSIAYTVDEKAEVIANEDGDRQIPTILSYVDGDEYYGAQAKSFLIRNPSNTIAYFKEFLGQDFKSIDPTYNHASAHPQDVNGTVSFAVKDKEGAEEPSNVSVTEAATRYIRRLVGSASDYLGKKVTSAVITVPTNFSEKQKEALTKAANDAGLEVLQIISDPIAAILAYDARPEAKVEDKIVVVADLGGTRSDVAVIASRGGMYTVLATAHDYEFSGSHLDQVVMDHFAKEFIKKHTTDPRENARSLAKLRAESESTKKALSLGTNASFSVESLAEGIDFTSTINRLRYEMIARKVFDGFNRLVEGVVKKAELDVLDIDEVILAGGTAHTPRIAANFANLFPESTNVIAPATQASAINPSELLARGAALQASLIQEYEAEDIDQSTHAAVTVVKHIANAIGVVGANDEFVPVVPAETAVPARRTIHVAGPKEGGDVLIRIVEGGAHIKVTKPEPKAKPEANGDDSDSDFDSDEEEETREKIWKVGPTLAEAAVRGVSKGAKVEVTINVAADLGVTITAREVGGKGGVRGNIKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9E7</accession>
    <name>A0A1B7Y9E7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157112.1">
        <property type="nucleotide sequence ID" value="XM_018302334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9E7"/>
    <dbReference type="GeneID" id="28866441"/>
    <dbReference type="KEGG" id="chig:CH63R_07359"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07359"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="27696" checksum="E76F7F4FCB2BE7AA" modified="2016-11-02" version="1">MPTTLPGTTVIVTGSGGGLGKAIAEAYLATGANVVIADIDEARVAAVASEHRDTYAGRLHTAVVDVTSEASVEALVSGVVERFGRLDVVVNNAGVMDRFDPAGDCAKDTWDRVLAVNLTGPFLTTKFAVNQFLNQGPAGAGGGPRGLIINVGSNASYRGMTSGVAYTASKHGVVALTKNSAGFYGDKGIYSVALLVGPMDTTNIMDAFAGGVNQPAMEKVTAAMPEYKRGETGLDPAAVAKYCVFLTDKDIASSANGSCVVLNRNWPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9P6</accession>
    <name>A0A1B7Y9P6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_07576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157329.1">
        <property type="nucleotide sequence ID" value="XM_018302551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9P6"/>
    <dbReference type="GeneID" id="28866658"/>
    <dbReference type="KEGG" id="chig:CH63R_07576"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07576"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="594" mass="63945" checksum="945E32561DE0D067" modified="2016-11-02" version="1">MAAQSSSGRQVSDHLSYPNPSLTDTAGFAAANFAPRRGFEYSAASRRKRMIRKVLIVTSLLLGLFLATLDTSIVATSLITISEEFGDYANAPWVLLAYLLTYMGCAVGIAKFSDIYGRRTLLFYSWLFFLLFSLMCACATSMPMLIIGRALQGVGGSGLYSLAQTCLLEHGPASNPPLMGALIGATLAVAFLLGPILGGAIVSKITWRWIFGINIPLGIAAVISISACYPRDRRAFTIFSMSGLRKIDYCGMAALFAASVFLVFAVERGGSPLHGWAHPSVITSFVVSGVNWVLFGISETYLFYKYCQYPDHVGCLHIEPVFPVQLAQRRPFMGGLAVTFLTGVPYVALTVIIPERMQVLEQQTPLQSGLYLLPMLGACALGSFLAGAICSRSNRSALVMIVASVAQLLGISLMLIVSPVDSSFVPAYGFTLVFGLGVGLVFGSATILSGVETDSTRDHAVAQGALAQARALGSCLGVATCTALFNKRLDALNKHLTQDQLEVLYQTPTASARWDRNLLRLVQNVYAAAFKDQTIFMIVVCSIMVVAALLAWENSPKPISCLAGHAQRADKTRLQREHDNDGTEMSDMASVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA22</accession>
    <name>A0A1B7YA22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA-splicing factor slt-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07674</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157427.1">
        <property type="nucleotide sequence ID" value="XM_018302649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA22"/>
    <dbReference type="GeneID" id="28866756"/>
    <dbReference type="KEGG" id="chig:CH63R_07674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07674"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="385" mass="41309" checksum="7D4665405F76CCE0" modified="2016-11-02" version="1">MPPQIKQDLNRSGWESTDFPSVCENCLPENPYVKMLKEDYGAECKLCTRPFTVFSWSADRAHGRKKRTNICLTCARLKNCCQACMLDLSFGLPIVVRDAALKMVAPGPSSDINREYFAQNNERAIEEGRAGVEEYEKTDEKARELLRRLAASKPYFRKGRPVEGLNNDAQSGSSSRGGVGGNPVVGAGVGGPGPIRTRDSRAAAAVGARSGRSKQAFPSAAQLPPGPQDWMPPADKNIMSLFVTGVEDDLPEHKIREFFKAHGKIKSLVCSHMSHCAFVNYDTREAAEKAAAACQGRAVIAGCPLRVRWGVPKAIGTMDKEQRSQMLTDARRGQGGARGGDGRGGRKQVSGDSGIGDAAQPSVAPAVALPPGADDGFKYASLQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAW3</accession>
    <name>A0A1B7YAW3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_07869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157621.1">
        <property type="nucleotide sequence ID" value="XM_018302843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAW3"/>
    <dbReference type="GeneID" id="28866950"/>
    <dbReference type="KEGG" id="chig:CH63R_07869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07869"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="166"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="615" mass="66151" checksum="EC40D28B7494B427" modified="2016-11-02" version="1">MGSEKDVEAEPPGAAVTTPATGAGAHGLRGGSSDQATTTIMMEKEPEHGQRHRFASADGLERVHETRMEKRNSFDVDDATDGDQPSLEDIAVERLQTARSHASARSRLSRVASLASRRREADGRLSVMAAHHDHPLSDLPAGLVGWDTPSDPAMPMNLPPRRKWLAIWFLAAITFMTPFASSILAPAVGPLNEDLGNDDMALGTLPVSIYLLGYAVGPLFLAPLSEMYGRRPVLNAANVFFCACLAGCALAPSLASLIAFRFLTGVGGSGCLAIGGGVIADLFPVAERGAAISLWMIGPLIGPTAAPIAGAYIAQDLGWRWSSWVSLIAAAPVTLIIALFNRETNPRVLIDRKVARLRAELGRPDLRSVYDHDDDCHRLPAGTPRPTSSQLLVRGLVRPLKMLFLSPILFSVSLYCAFAYGVLYLLFSTIPLVFASTYGFSVGTAGLVYIPLGLGYLIGMALFAALSDRTVVRMTKANGGVYEPEMRLPDCIYFAALLPVTFFWYGWTAEFETHWAAPVVSLLPFGVAILGIWQPIQAYVIDAYPSYAASGMAALTVFRSVVAAFLPMAGPPMYDALGLGWGNSVLGFVAVALIPVPTLIYRYGGRLRKWQKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB43</accession>
    <name>A0A1B7YB43_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157766.1">
        <property type="nucleotide sequence ID" value="XM_018302988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB43"/>
    <dbReference type="GeneID" id="28867095"/>
    <dbReference type="KEGG" id="chig:CH63R_08014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08014"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="247" mass="25824" checksum="8A95770160C74E85" modified="2016-11-02" version="1">MDNDMKKDAARLERTGSQTGAANGTGNGNGNGDDDYRLAQLGHAQELKRQFSLPALGALCLCLMATWEALSTVIAPALLSGGAPCLFYNLIASTICTVCIASSLGEIASIYPTAGGQYHWVAALSPPSTRSAAAFTTGWVSVGGQVVLTSSAAFAAGLQAQALIVLNNDGSYAPARWQGMLFYWAVLAYGMAMNIWGHRLLPSANLIAGTTTQPCPVFPLPLLRVLVLSLLGNTAFIVFTHSATLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBV8</accession>
    <name>A0A1B7YBV8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157972.1">
        <property type="nucleotide sequence ID" value="XM_018303194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBV8"/>
    <dbReference type="GeneID" id="28867301"/>
    <dbReference type="KEGG" id="chig:CH63R_08220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08220"/>
    <dbReference type="OrthoDB" id="3166386at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="566" mass="62461" checksum="7628698CFBFF935D" modified="2016-11-02" version="1">MADSGTGTYTTASASDIITYIGVPLAVLGVLPILYNTIATLAARSRIRRMLRHARLTALTRSDVVNRVIEVDLPRYAVTPWDRFDHREEYWSLARYPSSIPGGTWTTFNWRTNTIGLKTQRVEYADQLRQPQVEVSFEELVSYLLDLGAVPDAHGWRLLRSTGLWTPIGCTLMQSPDGQHKALTIAPLDDSDGHLSLSVMWSSHWTTRSHESLPPYWVRLPPPPETVTATTVEDHPDALDDIKQSPLSQKSSLSSISRAARTAANAPIACKISSHGLISAHPEPDDNARPATPLHIDHVRIRPGPSVPTAGVWFASAATAYGTSSTTVLWNYRIPDDVLAFARGSSVPCGVLELLGIADASQTPEWATCHDDMRDNLDLVGRRMREQRNAIAAESRLPPKEKEQAVRDRMRKESEQRLDDLRDKMRLDAQRRDLRTHEAIQSPKWDAALVASHTLPWLRQHGHLPSSSDTTAPETPRAVVGGLLHRMLLDGAFADDVASVLGAWKAWADNGGMRKSDLEALREARTSFALASLLVAVIRDAGVATEGGLAVDLQECLGMWRQVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCC2</accession>
    <name>A0A1B7YCC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158142.1">
        <property type="nucleotide sequence ID" value="XM_018303364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCC2"/>
    <dbReference type="GeneID" id="28867471"/>
    <dbReference type="KEGG" id="chig:CH63R_08390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08390"/>
    <dbReference type="OrthoDB" id="4809885at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="112" mass="12608" checksum="E009D13416B23C7D" modified="2016-11-02" version="1">MAFLKKNSSHKNRLEVKEDTGGKAVGQASSSSLPKSAPTPKAANPFPHEQLMRAKYLDQRKLKNSLDSIYGEGKYQVKVKRSSNFDLFSLTASILKDDLAQLEQRVRLHYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD72</accession>
    <name>A0A1B7YD72_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158560.1">
        <property type="nucleotide sequence ID" value="XM_018300710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD72"/>
    <dbReference type="GeneID" id="28864817"/>
    <dbReference type="KEGG" id="chig:CH63R_05735"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05735"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="110" mass="11924" checksum="6C9FC7CF354A2713" modified="2016-11-02" version="1">MPTELARVVSKAVRKLHVAGTAQTLFLLDTDCIQRKLHALCASLDVFSTPLLEGLSCTREHRSVMWHSPDDAKTLGRGRVPHKSYGKMINSTDGATLQDLPGQSKLSGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE62</accession>
    <name>A0A1B7YE62_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CH63R_06011</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158836.1">
        <property type="nucleotide sequence ID" value="XM_018300986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE62"/>
    <dbReference type="GeneID" id="28865093"/>
    <dbReference type="KEGG" id="chig:CH63R_06011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06011"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="42"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="22">
        <location>
            <begin position="774"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="1083"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="954"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1054"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OBR10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1234" mass="136486" checksum="699A0D2FA7490133" modified="2016-11-02" version="1">MGISRRPKDKSAKTGPAGPSGAAGGGGKPKKATYEVTKKKEIGVSDLTLLSKVSNEAINDNLKKRFEGQEIYTYIGHVLVSVNPFRDLGIYTDQVLDSYKGKNRLEMPPHVFAIAESAYYNMKAYQDNQCVIISGESGAGKTEAAKRIMQYIANVSGGESGDIKQIKDMVLATNPLLESFGNAKTLRNNNSSRFGKYLQIHFNAQGEPVGADITNYLLEKSRVVGQIINERNFHIFYQFTKGASQTYRQQFGIQTPETYVYTSRSKCLEVDGIDDLAEYNDTLEAMKIIGLSQGEQDEIFRMLAAILWAGNIQFHEGDDGYAAVSDQSVVDFLAYLLEVTPEQLIKAITIRILTPRNGEVIESPTNPAQAAATRDALAKAIYSNLFDWIVERVNKSLKAKQATSNNIGILDIYGFEIFEKNSFEQLCINYVNEKLQQIFIQLTLKAEQDEYAREQIQWTPIKYFDNKIVCDLIESVRPPGVLSAMKDATKTAHADPAASDRTFMQSINGMSNPHLTPRQGSFIIKHYAGEVSYTVDGITDKNKDLLLKGLLNLFSGSSNQFVHALFPHQVDQDNRKQPPSAGDRIRASANALVETLMKCQPSYIRTIKPNENKSPSEYNVPNVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVDRFFLLSPATSYAGEYTWQGSYQDAVKQILKDTSIPKEEWQMGTTKAFIKSPETLFALEHMRDRYWHNMATRIQRMWRAYLAYRAESATRIQRFWRKKRTGAEYLQLRDQGHRVLQNRKERRRYSLLGSRRFLGDYLGINASMGPGSQIRNAIDISNNEKVVFSCRGEILEAKFGRSSKPSPRILVVTSSKFYIVAQMLVNGQPQISVERSMPLGAIKFIAASTARDDWFSLGVGSPQEADPLLNCVLKTEMFTQMQRVMPGGFNLKIGEVIEYAKKPGKMQAVKVLKDSQQAVDYYKSGAVHTQPGEPPSSVSKPTPKGKPVAARPITRGKLIKPGGPNGRPSRMTNTNRTPQPRPAASTARTGPAATPQLPAAASSAKTGPFGRQQQQQQQQPAAVATSIPTHTKPQAANSAATRMPPPPPPAAPPAKNKIMAKVLYDFAGQKENELTVRAGDMIEIVQKENNGWWLAKNGGSQAWVPAAYVEEQAPAPVVAPRPPPPPPSANGAAARGKPTPPQPPVKRPAAGRKPAVAQPRDSGLSLNGASGSDNSRSNTPTLGNSLADALLARKNAMQKKDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF22</accession>
    <name>A0A1B7YF22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159288.1">
        <property type="nucleotide sequence ID" value="XM_018301438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF22"/>
    <dbReference type="GeneID" id="28865545"/>
    <dbReference type="KEGG" id="chig:CH63R_06463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06463"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="506" mass="56344" checksum="16B6180BDB754758" modified="2016-11-02" version="1">MMESSKDQKQVEKNKEPVFVPDDVEVALKVSPEARDYSGAHAKSDPAEIALVRRLDWMIMPILWGMYWLNYLDRNAIALARLNTLEEDLNLSSTEYQTCVSILFVGYVIVGIPANMVVTRVRPSLWMSSCMAIWAIISALTAVSHNYTGLLLTRFFLGITEAPYYPGALYVLATFYTRKELATRISILYTGNILATAFAGLIALGIFQMHGMAGIAGWRWLFIIQGVVTFILAIVAYFVLPDEPLTTRWLTPEERILANERILRDTVGNTGQTTTWSGLLEAAKDPKVWLFTLMQHCHLGANGFKNFFPTAVETLGFNETITLVLTCPPYLIAGVISIAWSWSSGRFNERTWHITIAKSVAVFGFVLGCATLNTGARYSSLHPQEHVEPAPADDTPPSPVAMVVFSVGTYAVNSIILGWVSATCSQTKEKKASSLAIVNCIAVASFIWTPYMWPKSDEPRYVMAMSSSAALSIATALGAWAMRFWLMRENKKIRRSENESVLFYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHL8</accession>
    <name>A0A1B7YHL8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159845.1">
        <property type="nucleotide sequence ID" value="XM_018298599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHL8"/>
    <dbReference type="GeneID" id="28862706"/>
    <dbReference type="KEGG" id="chig:CH63R_03624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03624"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="403" mass="44496" checksum="688BF5690B961484" modified="2016-11-02" version="1">MAEVRAATQSPSRSPPPPQSPEAGAGESEARESIAREVGPSEAVPQEAGPQEAGSPETGRQETASPAVNHSPPPNIEAQDDGDEGDEGDGYETASNTSSNDTSSLASSIRDYNFENKRRYHKFKEGRYAFPNDDAEQEREDMKHAMVVTLCGGALHSAPLENPHKILDIGTGTGIWAIDMGDEYPEAEVTGIDLSPIQPMYVPVNVSFVVDDAEAEWLYSDDSIDYIHIRNMGAAIKDWDKLLAQAYRCLKPGGWIELQEMKWNFNCDDDTMPPTYAVTKMMKHIWEGLNKFGIEADVADTNPQRLKDAGFVNQVHDVQKVPVGEWPKREDLRMIGAYCKAVIYDGLHGITVGPMTRGLGWSPEEVEVFLIDVRKDLLNTSIHSYVFYHSLAGQKPLKTEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJV4</accession>
    <name>A0A1B7YJV4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160792.1">
        <property type="nucleotide sequence ID" value="XM_018299546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJV4"/>
    <dbReference type="GeneID" id="28863653"/>
    <dbReference type="KEGG" id="chig:CH63R_04571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04571"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="198" mass="20239" checksum="89925B0460EDB832" modified="2016-11-02" version="1">MSSSGSPSLPKMTTRHRKGSEHLERSPRLSPSHESPTTPRDEIAATAILAAIQDSAPASALDRLADHDLPSFRSVMEEATALANLALPQTNIEPISRPSSTSTSESASASLPQLPGISALAQANSATSSPQMREAIPATAPAASTPTHAPAPAPAPAPAPAPTPTYASGGGSTTVCRLPFPIVPPEKPIPKAPKSIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKC9</accession>
    <name>A0A1B7YKC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_04825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161046.1">
        <property type="nucleotide sequence ID" value="XM_018299800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKC9"/>
    <dbReference type="GeneID" id="28863907"/>
    <dbReference type="KEGG" id="chig:CH63R_04825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04825"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="723" mass="81428" checksum="7C49019627B025B3" modified="2016-11-02" version="1">MSSTAAPLPRLPACQLCYRKKIKCDSTRPRCSPCTKSDSQCVVLSPGGEEPLSRAEIDRLEQEERALSSRLQTLRRNDEGSTPRAPDRPAAGTGHTAASVESSDVSPSDVEGLGFMASLFTDPDLRRNNTELLQILAKVPNAPEPSISPCELPSSEDAEFLFERYIDWSHVQSPFLCRDEIRELRRRLFSFPLAGQSAPDHDLFRAFMILAVGSVFPYRNGAHHQHPEGYYLAALQHLGADFLTRGLDSVQDLLLVCRFGIYHRIGTSIWDVIRLCGRLCIEQGLHLNDQPSKSLLHAQMKRRVFWYFYIIDRYSSTLLGKPFTINDRDIETSFPVDANDEDLVAADQSLRDLAAFQMTHVPLGPSEMTVFFTAVRLRQISSRIHTEFSKLSRNHFEVSRSHLAPGHIYTTLTRLMRELQEWRDHAPVFPRPKCLYESQDWFDLLLAREQLYLVRRAIDLVPKREGKTPRHVSVLYLKTALRTIEVYSLLCQNRPLITHTRSYFHMMFTAGLSVIFCVSAATALDVEDVQSASAGLTQCEETLRDMVEQLASARHYVVVFEALRHNTFRKLNRVLEALRPDNGHQCVTADPSASTRPSGFSAHSSHPLPSSLGTERPDHAEYRMEDVSSSQAAQNHVPVGDTSNTLNFSLPLDNRMAGDATTYLFTGRSNFGSLGITGNPSPSSDLLDWAFLNDETLWNMETVLGEYVYGDPSRHAGFDGFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLC4</accession>
    <name>A0A1B7YLC4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Potassium ion channel Yvc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_05111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161332.1">
        <property type="nucleotide sequence ID" value="XM_018300086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLC4"/>
    <dbReference type="GeneID" id="28864193"/>
    <dbReference type="KEGG" id="chig:CH63R_05111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05111"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062815" evidence="3">
        <location>
            <begin position="16"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="5">
        <location>
            <begin position="357"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="789" mass="88286" checksum="B1F1AB27702E0AAC" modified="2016-11-02" version="1">MRASKLSSFLLPAFAFSSAPLTQKNRKREPVHWLLSIVPALLEIDNDDDDEDEDDNDAVAAERPNRSKLPDNSSLGPRPDPNRTRQSQSPWPTSTGSPACLAGTGTRDIITTSTRIGSATTADAPAPIAYKRVYCPEPVLPQYRSEHLESAIPAPEVTKIALKLRHLIELAVPCELDEDEITKAHSKIITTKVIKAAKEAGGSHYGSCVVFCLIVCKRWFKHQALVELWDADLHRVRAVACEVIAKQIIETEEDLQYLMHSVLLRRYSILIDGESTPPANVIEKAVDLHAVRVIGSSGYQKCISYLWKGWLVQDEDDPAVFVDYKDKTNPSFLVHMDPDRIRAPMYQNATQVLISLVYIGLYTAVINSVNAKGELDTAEVVLYIFTFGFICEEVTKFWKAGYHILGFWNAFNGVLYSFISLSLILRIIGLTHGESEEARRYYSELSYNFLAFSAPMIWSRLLLYLDSFRFFGAMLVVLKVMMKESIIFFALLAVLIIGFLQAFVGLDLADDLVADDILFIISAMANAIMQSPDFDGFDRFSPPFGIILYYCFTFIVMVVLLNILIALYNSAYEDIYDNANDEYLALFAQKTMQFVRAPDENVYIPPFNLIEMVVIALFWWMEKSKFERMSDIIMGILYSPVLVVAAVFETQSAAEIRSNRARGEEDDDTIEEWEQMMDQVDFESDGWNKVCMTAKTNLDTDPTIAEVQKLRSEVEELKKMLVDISKAVVASGDKAGKAPAADLIDLGEAAEGSSKKKKNKNKKGKKNKKDKQAAGDGQATGGSSSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLD1</accession>
    <name>A0A1B7YLD1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitin deacetylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_05142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161363.1">
        <property type="nucleotide sequence ID" value="XM_018300117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLD1"/>
    <dbReference type="GeneID" id="28864224"/>
    <dbReference type="KEGG" id="chig:CH63R_05142"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05142"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="636" mass="69431" checksum="8611CA80D76E09AE" modified="2016-11-02" version="1">MQKPSGAPCDKVDVTEEAPSTAYTRALEARVAFLESKLAQIPTPGAASTPSKDVASNQSVSSGRDKNALSDAVAHVSLGNLEAPVYVGPSSGLSLALNLGEMVQATVWNKMLPDIQDGIVSNQADCINPGPKCLAVEDMLAHSIVKEPPTEEQGAKMLKAYTSQLHSKYPFLEPEELWKLHKERDALAATPTQSLTKAERFGIFKLYLVYAIGATIVQLTQRGPGLSPEHISAARESGTVQNIEAMTLLVMFHLRSTSSHGLWYMIGLAMRTSIDLGLHRAAHEQNVSEPPVVQRRRRLFWSVYSLERTIAVSLGRPLSIADNQIDVELPHAIIGDGNIQPAGALAGNDITLAIVLFRLRRIESRIHHSVYRTDKTLDALRPKLDRLYQLLQSWRGSLTDWIPASHPDTNYALLLYNRALRLLVQPFLPILPASDPFYGLCMRAAGDICQSHKRLHQTLDYGHSFIAVQTVFVAGVTLLYGLWTQGDAVWSVALSNDIRACSLVLFVMGERAPWVRKYRDAFEVLVNAALEKLQDKECGLAEMASARMRAEKATGSSGSGGQDADRGSAGVNTAQAVDDFNDFLPSGDGGVFAGGEFEGAWPMVAELANWIDQDGGSPVWMPNFELLQSLSGTWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLP0</accession>
    <name>A0A1B7YLP0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_05257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161478.1">
        <property type="nucleotide sequence ID" value="XM_018300232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLP0"/>
    <dbReference type="GeneID" id="28864339"/>
    <dbReference type="KEGG" id="chig:CH63R_05257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05257"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="11">
        <location>
            <begin position="81"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="626"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="719"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="860" mass="93245" checksum="AB885307ED4BF2AD" modified="2016-11-02" version="1">MSSTALTISQPSRSLHSRRKSSLSAARLNENSRNVDPVAMMPSASQSQPSSQQSFTMSQQSQAGYRNYGADSRLANEAPQIYSAVYSGVDVYEMEVNGIAVMRRRQDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQGGYGKYQGTWIKFDRGVEVCRQYGVEEVLRPLLTYDMGQDGGVAGRGDFNTPTKEQAMAAQRKRLYNAGNEARTNGMAGLNGTFFKNISATASHAVAAISKARFDSPGPRSRNGPTKTPSFSRQSSMQNGDDFPGNSQQSFASDFGNNPNDSAYSTQQTSQQPFADGPEPPRKRQRVTMTPQESFGAYSNSMEMYQNNFPGSPTEPNESFIYSQANPTTHDGHSPLSPLPFEMSPDAESKRSMLMSLFMDSATSDQSKHEMLRTLAPIELDMPIDQQSHTALHWAATLSRMSLLRSLITAGASPFRVNASGETALVRACVVTNSMDLGQFPELLDVLGGTIEVRDSKGRTVLHHIAMTSAVKGRNAASRYYLESLLEWVVRQGSNPATNGKGDSAPASSQSQPQAQAQPKMGIARFMTEIVNAQDHAGDTALNIAARIGNRSIISQLLEVGADPNIANRAGLRPVDFGIGGDATEEGSKILTGAHGAGTNEINGETERDGIVSSERTKESSDDIISSITHLLNEASSTFQGEVKTKQAVIESLHSTLRTTSAQLGEARRNLEAMQATLRKQQLARQKVSNLSHAREEEQVRLTQEQNRAGRTDSLSSSWETELSAALETAGTNGEGGLLPSAAVLKARLAAVSARRDVTRKMAGALKGRSKDLEVKYRRVVAMCTGEPEDQVDAVVDGLLRAVESEKGELEVERVRRFLGGVEGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YML2</accession>
    <name>A0A1B7YML2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161822.1">
        <property type="nucleotide sequence ID" value="XM_018297006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YML2"/>
    <dbReference type="GeneID" id="28861113"/>
    <dbReference type="KEGG" id="chig:CH63R_02031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02031"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601787" description="cellulase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="501" mass="52302" checksum="BFF6AD03F4302B4C" modified="2016-11-02" version="1">MKGLIVSAAIVGGAMAQAGPYMPCGGKGWTGATTCVSGYTCVVQNDYYSQCVQGSGPGGVSALAQATTLRTSTRRPCKSKAVSAGAVVPQVPTTSRSASSTSVPAVAVSSAKPVDTKPAPSSSIPAAAVPTPAKSSAAAVKSKAAEIKPATTVKLSDAAIVPVSTAAPVTKPVSSAAAATTSKASAPAASASATPGKSGKFKWFGTNQSGAEFGPGSTPGTLGKDYTFPDTAKITTLMNDGYTTFRVQFLMERLSPDSLTGKFNAEYLAGLTKVVEHITSAGGNAVLDPHNYGRYGGSIITDTAAFKTFFTNLATQFKSNDKVVFDTNNEYNSMDQDLVLRLNQAAVDGIRAAGSEHWIWAEGNSWTGAHSWTSVNDNMKGLKDPLGKTVYEMHQYLDGDSSGTSADCVSATIGVERVKDATEWLRANKKVGVLGEFAGGANAQCKEAVTGLLDYLQENSDVWLGATWWAAGPWWASYMYSFEPETGAGYNYYNEVLKKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMN4</accession>
    <name>A0A1B7YMN4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161834.1">
        <property type="nucleotide sequence ID" value="XM_018297018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMN4"/>
    <dbReference type="GeneID" id="28861125"/>
    <dbReference type="KEGG" id="chig:CH63R_02043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02043"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="302" mass="32317" checksum="12369960D90E14AF" modified="2016-11-02" version="1">MDDLSSGLPSDYIYKLLQFTPRQHHDVYPAIDPSNPELSLAGKVVLVTGASRGIGANGIVPSLAKAGAAGIVLVATNAEKLKAVELAVRDINPSTRVLVAAADISNEQSVASVFKSATETFGRVDILVHNAGVMNQMSNIHEEDATAFWKQYEINTFGTFLVAQYFIKSLPSPESPGVILYIGTAASWARNSSFAGYSGSKLAAQKLISDIASGYPNITAISASPGLVETDMLQLRGFDVSTPQLVGGAVVWLSGDRARFLSGRAISVEWDLEDLVARKDEIVKEDLLIMRMAGKFGHEQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN15</accession>
    <name>A0A1B7YN15_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161926.1">
        <property type="nucleotide sequence ID" value="XM_018297110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN15"/>
    <dbReference type="GeneID" id="28861217"/>
    <dbReference type="KEGG" id="chig:CH63R_02135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02135"/>
    <dbReference type="OrthoDB" id="4845523at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="89" mass="9522" checksum="EFE37497EB9878C4" modified="2016-11-02" version="1">MAKQKTAPVASSAQASDGGASTGQQQQQAGSGRPATQLEQLAGLLVPPAWARRIIFVAVIIYLTPMLLAHWVDTSTRIIRFIQSFTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNB7</accession>
    <name>A0A1B7YNB7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162047.1">
        <property type="nucleotide sequence ID" value="XM_018297231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNB7"/>
    <dbReference type="GeneID" id="28861338"/>
    <dbReference type="KEGG" id="chig:CH63R_02256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02256"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7793" checksum="6D6189E0DD4EDFA2" modified="2016-11-02" version="1">MAFFRDGSALDDGDDQQFQSLVCHDSAHPVCDLDRFRLAYAGLHGDPDSNRRAVEPKSSTWFWFRGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNY1</accession>
    <name>A0A1B7YNY1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162169.1">
        <property type="nucleotide sequence ID" value="XM_018297353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNY1"/>
    <dbReference type="GeneID" id="28861460"/>
    <dbReference type="KEGG" id="chig:CH63R_02378"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02378"/>
    <dbReference type="OrthoDB" id="4833509at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="1">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="196" mass="21515" checksum="D593BEA4912C251C" modified="2016-11-02" version="1">MGVTPFPNAVCEPFTTSNNVAVAVFRQDPVRFNKSHYMTIKMVTGHSKAEATIWNRNRAGEYEDGFCDNIRGTHSNSSSPRMPLVAECVAVKEWAAANAGHWVVSKNDLNKHNRVVLLAVASCAFVVGATEEKRTDTGIIISSKDVTKAMQDVIKKPQIGGRVEVAGRFSCITGDGRDKVAANWYIANTEIIDWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP10</accession>
    <name>A0A1B7YP10_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_02408</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162199.1">
        <property type="nucleotide sequence ID" value="XM_018297383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP10"/>
    <dbReference type="GeneID" id="28861490"/>
    <dbReference type="KEGG" id="chig:CH63R_02408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02408"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="704"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1117"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR13682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129533" checksum="0143C4C40D26B5F8" modified="2016-11-02" version="1">MAAITNHVLRGSTASFIRLARHHASRRLALRSHARWQSSLAAETANVDNIKERQEKPNILSQARYSDIGVQHLSAHVYKQIFPDGTTPPPPELVELSRDHLRRHDLLGKNTDNSDPIAFDLPELQGRTLDEHFHKLAVDSAEPYLSLAKQFARANAPPKPRKWVRRSGWTKYYSDGRTEAVDAPDDSMLCFDTEVLWKESSFAVMACASSPTAWYAWLSPWLLGESESDRHLIPLGDPTKERVIVGHNVGYDRARILEEYDVKQTRNSFMDTMSLHVAVNGMCSQQRPTWMKHKKSRELRDKIASQTDDVQLAELLGNSALRQEEEELWVDRSSVNSLRDVAKFHLDVTIDKAVRDEFGTLDRAGVLGKLDNLLDYCAADVAITHRVYQIVFPNFLDTCPHPVSFAALRHLSSVILPVNKTWDAYIHNAEATYRELSDAVQERLIGLTEQALAIKDDPEKWGNDPWLKQLDWSGQEIKMVKGKKKNDPPRPAARQKMPGMPQWYKDLFPKNDSPINITVRTRIAPILLKLSWDNHPLFWSDKYGWTFRVAASEAADYQQKQMIQCDFSDTESDAALQEDGGLFFKLPHKDGPMARCVNPMAKGYLSYFEKGTLSSEYPYAKEALEMNASCSYWISARDRIRSQMVVYEDDIPGEGKEASSKKKRDPEHVQGYILPQIIPMGTITRRAVENTWLTASNAKKNRVGSELKSMVKAPPGYSFVGADVDSEELWIASLVGDATFKLHGGNAIGFMTLEGTKAAGTDLHSRTASILGITRNDAKVFNYGRIYGAGLKFAGQLLRQFNPNLSEKETNETASRLYAKTKGTKTSRSVLSKRPFWRGGTESFVFNKLEEFAAQERPRTFVLGAGITEALMRRFINQNGYLTSRINWAIQSSGVDYLHLLIVGMDYLTRRFNIDARLAITVHDEIRYLVRDHDKYRAAMALQVANVWTRAMFAQQVGINDLPQSVAYFSAIDIDHVLRKEVDMDCVTPSHKTAIPPGESIDITALLAKGAEACLDPSIVPDPAHAPKLDGIEYTPRTPVMDTLEDSTSADPYFLKAQIVSTEIELSQVLKDRRQAVKVQEEKKPRAARPKKERSVLPYQSDAKLVPTMTVSDAFGHNKYGSRFEPKNRWTTWQKEKGTGRFGPSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ11</accession>
    <name>A0A1B7YQ11_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alkaline proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162653.1">
        <property type="nucleotide sequence ID" value="XM_018297837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ11"/>
    <dbReference type="GeneID" id="28861944"/>
    <dbReference type="KEGG" id="chig:CH63R_02862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02862"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601826" evidence="8">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="162"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="412" mass="42949" checksum="604D672BA84E10BE" modified="2016-11-02" version="1">MANLRRLALAVGALLPAVLAAPAVYRRSEPEAVPGKYIVTLKEDAVNVESHLNWVTDVHRRSLGKRDTVGIENKFNISNWNAYSGEFDDATIEEIKASPEVAIVEPDYYMYLFDDVDAELSERALTTQSGSPWGLGATSHRSPGSTSYIYDTSAGADTFAYVVDSGVLATHTQFGGRVTLGFNAFTGAHVDGAGHGTHVAGTIGGSTYGVAKQTNIISVKVFEGRRSTTAAILSGFNWAVNDITSKNRASRSVINMSLGGPATTTWTTAINAAYSRGVLSVVAAGNGDDNNIPLPVSEVSPANVPNALTVGAVDSTWRVSTFTNYGPGVDIFGPGVAVLSSWIGSNTATNSIPGTSMAAPHVAGLAVYLQALEGLSTPAAVTNRIKALATPGRVLGDLRGSANLVLYNGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ76</accession>
    <name>A0A1B7YQ76_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mediator of rna polymerase ii transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162565.1">
        <property type="nucleotide sequence ID" value="XM_018297749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ76"/>
    <dbReference type="GeneID" id="28861856"/>
    <dbReference type="KEGG" id="chig:CH63R_02774"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02774"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="201" mass="22209" checksum="80F3BBA5FB23FDA2" modified="2016-11-02" version="1">MGPHASSPFTCTFCYGSSDGPPHVLGHEARLTCSPCHAALIDLAICWSGEMGCWRRQGRTAEKDPSVHSVIESRFIFSPSSGRRIARRSQRGSGDAGYGFYNIRLHQRSYRPTSLQTKSNEAHTGMDAAISRDSTLRRETRGQHAYSSIGKSRADTGHVDIRNIDFGIGKFTYTDRPTNYTPSSFTAFAKPNQFPSRLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQE7</accession>
    <name>A0A1B7YQE7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_02959</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162750.1">
        <property type="nucleotide sequence ID" value="XM_018297934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQE7"/>
    <dbReference type="GeneID" id="28862041"/>
    <dbReference type="KEGG" id="chig:CH63R_02959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02959"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="98"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="431" mass="46559" checksum="82EA8B7C5DF28E23" modified="2016-11-02" version="1">MPEARFCNARVVEPPSPPNLIPPDFHICPETRPRRGPRIGLSKRKRETLIELKKKGSSATMNRLGVRRFATTAARAIDPPSAYSLTLSRAQGVVKGLTGAIGNTPLIRLNRLSAETGCEVLGKAEFMNPGGSVKDRAALYVVKDAEERGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFENPENYNHQARRHAERLDNAVWTNQFDNTANRRAHIETTGPEIWEQTRGGIDAFTCATGTAGTLAGITRYLKDVSGGRVKSFLADPPGSVLHSYVSSGGKLVERTGSSITEGIGQGRITDNLKPDIGLVDGSLTIADEKSIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGNTVVTILCDGAYRYADRLFSRKWLAEKKLLGAIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR72</accession>
    <name>A0A1B7YR72_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nacht and wd40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163048.1">
        <property type="nucleotide sequence ID" value="XM_018298232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR72"/>
    <dbReference type="GeneID" id="28862339"/>
    <dbReference type="KEGG" id="chig:CH63R_03257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03257"/>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="426" mass="47460" checksum="4B6E909D9EB29998" modified="2016-11-02" version="1">MLRKKEVYTTITPIPGFIPRQLAIDILHSHSEVITLNPLVLDHKPIKAPRDAASDEYYSTWYEISQRIQYIPGIGKMGSGKISFNGCFHDMPWGLQTHTYAPMNIDIRIKYRIDGNQPGIEPPQPPEIGMSGLGVPADGLYLREDIEIRCNVTMVAFVKTQQKAASKEMVSRIIKKAELLDAGVLQAMFEDGKLKTFNPADRTNTAAQSGMRSPTLRHQRPDGSPRPESYSPTNAYHVPRPVSAQQNLRPGSQGGYGHQYGHQYSQSAELQSHTHQSAPQTAFVAELPGNFYHPNPQQQQQQQQQSNNPQPSPGLHPDRDSMSQQSQLSPDPNSWRWSQGQRSPSQQSSRPTSMASSEASSGFASPSLDHKGFSSELPTHPETQEEHRGNPTKAMEASRHRVNGPQAYQAYQAYSYNPQDYAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRZ7</accession>
    <name>A0A1B7YRZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163337.1">
        <property type="nucleotide sequence ID" value="XM_018298521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862628"/>
    <dbReference type="KEGG" id="chig:CH63R_03546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03546"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1394"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1371"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1484"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1643" mass="178016" checksum="23A10ED9E9AC1A69" modified="2016-11-02" version="1">MADENDGGVLQNELASVQQGLDIQNGPVFSARVLEKPDGKRLFFLVAHHLVVDLVSWRVIVDDLQLLLAGEPIIITAPTTSLSWGAWCRAQAVQLSAGGGGETLLRRHEAQVLEALRFWGMQDNPNVFADVQSSSVTMDKALTDVFLDAANRPLRTEPVEILATSLMGSFLDVFQQQRRQRQQEFTIFLEGHGRDLFPELDVSQTVGWFTTMFPLRLHAAVGGSFTERPRRVKDDRRMKSRAAMLDWAQILFRENNKNNNNSSGGGGGGGGGGCFAMPIEILLNYGGKVTSLDQTTGPLLSVTDPTTDFSLGDVSPDMARMALIEISAVVEGDQLRLSMRHNRRMNHQDGVRRWFREWINTLETQLRVLAGGLEESMTLADVPLLSLDCDDLARLELAELPARGLSVADIEDMYPCSALQQGILMSQDKGVGDYMTRVAWEVRGVAARPDEGDLERAWLAVVDRHDSLRTVFLDNPPYYTQAVLKTTRKRPEIRHVRLQSNDDDTNNNVFTKQNLLALAPSALDMKKGRGVTPPHCLFIVTTSDDDDVDRRRVGLVLSISHAVADEDSIDVLVRERELACAGKLPHGPGPSYRDFIALQMRGREASAAHWRSYVQSATPCLFPGRSDGSNDASPGARPHETPVPAVIDADLDFSAALHGFCRGSAVTLSDVAHVAWAAVLRVYTGCEAPMFGYLYSGRGANLAGVEHAVGAYVAMLVSRVPLDDDLPLDEAAQRAHDASIQVLQHAHCSLAGIQHELGLGALFNTGISLRRRNTAEGSGTTTTTTTTTAVSLQLMESLDATEYDMAITVAVDDDDDAVSISLAYRAEAVAWFQADKALALFLRALGIITLEPPSDAPAVHAWDGLLTYAELRRVCHGVAAQLVSRGVRPGDTVPVCFDKSLWYVVAVLGVLLSGAKLVPLDPALPQAAVDHILRSVSAGVAITSPRYESRVRSGLTDQSGGGGVIVLPDMLPAGNDDDDMPPSTRGIDLDATAYVIFTSGSTGSPKGVAFASSAFDVSVDEIVLTLTSGGCVCVPSDEARSDDLASAMAAMKVNTAMLTPSVARLLLHLAPDAIPTLRHVILGGEKVARQDLAAWSGRVARLDIVYGLTECAVASVLMPFVKGAEAAGCLGRPVGCAVWLVDPADENRLVPDGCTGERLIEGPVLASGYLGDPERTASAFISGPGWATDDSSSSSSSSSRRRRRFFRTGNLAWRDGGGVLHFEGRRDHQMKLRGLRFEAEDIEGHIARSWPRPGRRAFVDVVSRDDGSGRLRDMLVALIDDGGSPTGSDLEESAALHTSPLTEEFRQAAKETRRRLLEVVSAYMVPTLFIPINHMPMSVSGKTDRKRLKKLLQTLSMDEQMRALHLLPKKRNRPGLESLNDGVGTETRTDTETETETKTEGCLKATWARVLGSGSGSGGGGEEIDLDSHFFQIGGDSMTALRLSSALRADGFRLPVSAIFKTPVLRDMAEAMARWESPAKAEPMPEEEEEEEDYGWSGTATATAPTSLLDSRFEDVFPTTEFQSWCVNCCLADPRAYMTYFAMDVLGPLDPVRLRAAIQKTVLHLPILRTVFLSKNGDIFQAVLRSQETPILALAELDRHPQAELQTMAARDLAVADAAKSPFRLGTPVTGFTLISDPRSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTP5</accession>
    <name>A0A1B7YTP5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163785.1">
        <property type="nucleotide sequence ID" value="XM_018295423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTP5"/>
    <dbReference type="GeneID" id="28859530"/>
    <dbReference type="KEGG" id="chig:CH63R_00448"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00448"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="691"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="878" mass="96814" checksum="AD7823E9744EFF3C" modified="2016-11-02" version="1">MGPSSSAARKRTITPKKTLTKLPLSKKPARPNASILNFFQKTEKPEPTLFLDGHDKLVTPQNGGGGENEIYNAEPWEEDKRFNEVEAPSKRRRLSQGDEESEGEPLEEKKLESPMQSEQAALSPPLRTRLSTKQQAKHKGPFLDDSDSEEESGPAKTAGFLGTIRNRPPIVPPPKSEENSTSPVKSEEEDPMPLISLGKHESTPSAKETSCPPPPMKVEDSIDADFANVDEFGDLDEFPDGEDVGGEEYRMMRFMKEQARLEAEIEDEAAGSDSLDGLVDRGRLGDAMVANCPICDVSLAGITPDEATRHVNACLDGNPIPLPQPNETKKLKKGGIASPPMPASPEVSKRFARAAVPREGQANPFNLGEVDNKPTSAFSKLMSGHAEDAAWAGAAAAEHSARGKPAYQRTCPFYKIMPGFYICVDAFRYGAVKGCNAYFLSHFHSDHYIGLTANWTHGPIYCSKVTGDLVKMQLRVAAHWVRPLEFDETVKVPGTEGVTVTMISANHCPGSSLFLFEKSIGKGNSAKKQRILHCGDFRACPAQVGHPLLKPEVQDSISGKTKQQKIDVCYLDTTYLNPRYSFPPQNDVIKACADMCKSLAPDQSLMDDTWDKINREAGTGTVSKFFTKVNADGEVSESNPKTAPKERLLVICGTYSIGKERICKAIAQALGSKIFASKSKIRICSKLGDPELTALMTDNPYEAQVHMQMLMEIRAETLQEYLNSYKPHFSRIVGFRPSGWNYRPQGASKSVTASTQPSIIPTTQIFQAQAWRSRFGAKDFVPQRGSTKEAMCFGVPYSEHSSFRELAMFIMSLHIEKVVPTVNVGSEVSRKRMKGWIDKWLAERRKCGLLRPLEGEEGECKEVRLWDGKDSCGGGVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU50</accession>
    <name>A0A1B7YU50_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein Pro-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164060.1">
        <property type="nucleotide sequence ID" value="XM_018295698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU50"/>
    <dbReference type="GeneID" id="28859805"/>
    <dbReference type="KEGG" id="chig:CH63R_00723"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00723"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="693" mass="76593" checksum="72BBFB3EEC2C1C15" modified="2016-11-02" version="1">MSSLPPNHVRAGFMRSTAAVNMAVASSAKAKSACKANSNNNASSKSKTQMHRRSRTGCYTCRLRRKKCDEGSPMCSACKHLGLTCEYKRPMWWSNNDARRKHKDDIKMIIKRKKLSEKASHTIQTSVGSPPGLSHSLPTSATFSDPLDRTRSASIDSHFSTAFNFNSPPTVGAEYGAYNPQMHPDFMFGSFPSPYEIDVKTERQVYMNDVPTLRESTISTFSTFHTPPPPGTILPSSVPLEGEWTEQVYSERKESLSEETLNVNFFDFSHGPTMSNRQVAIELDENDQRLLDHFVQFVLPTIFPILDTNQHGSVGSDLILPALQNNKGYLHCCLSIAAQHYKATMNVSGEEIDQDIMRHRYATITALCDALTKDENHQEILDAALGLIFFQCVVGRFDDALPDIPWHQHFQAAINLVQKLDLPRLVSDPNEQMNQTPFNMTLTSWIDILGATMQGQAPTFAHTYREKHLSNSPSLGLRELMGCDDRVMYLISEIACLEALKGSGMDDITLCQHVHALGDQINITEIGEPGPKMPYNNNGSLSPKQLSKNMTAAFRLAARIYLCSLVPGFNPAQASCVGLVEKLSNVLQLIPSGPGGFDRSLVWVYLIGGSVSLHGSSFRALFEDRVAQLGDVSDCGSFGRVTSLLNEVWMQTSSIKSSDSCAGSPGSASGSEAVAYIHWRDVMQMKGWDFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVC9</accession>
    <name>A0A1B7YVC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cbs domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164517.1">
        <property type="nucleotide sequence ID" value="XM_018296155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVC9"/>
    <dbReference type="GeneID" id="28860262"/>
    <dbReference type="KEGG" id="chig:CH63R_01180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01180"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="481" mass="54599" checksum="3642EA8724A5CEA4" modified="2016-11-02" version="1">MFDASGQVFKEVVAPRPPDGYQNGRDWSRRTGRLPRRGRGGQGRKGPRSLADMAMHTVAENIGDVTEQHLAREDLPKRYLWRIWRLLENRGVCFQAWKVLSKFLLAEDDEKTLGLYRYRQHICLPSEDLRHYLKPLESPAVDFVTHLNITGACTFAENELLALARLRNLAVLEIIQPADELGLTFPKVDDRLVRGWSEIDDPFPLLRILRLWGDESVTRHSLKHVSKFPSLALYDVNASRSDWRGAVDMALGEGWEMEEPLHGPQDSLLWYLMLFDSVEESKPRQLQGLARNIDDGLMNFCQSSNQPIQFVPSRDTPPFLDHLGGAAKRNLSMYVDVPGYEAQTCKGFPFETWAFWLYSFIGQFTKDEDLKRAGLEMGQKTVSEQLVLPSKPLACLQLGHCGSARPAGIAPAVSYVRRGLFATSRYTFFRTSSSSTRQASARRTAELMKPTVQLGNVETGLNPNRKKRRRLDDILQSFMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW94</accession>
    <name>A0A1B7YW94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164833.1">
        <property type="nucleotide sequence ID" value="XM_018296471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW94"/>
    <dbReference type="GeneID" id="28860578"/>
    <dbReference type="KEGG" id="chig:CH63R_01496"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01496"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="5"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="46498" checksum="6562A1F1EA2EFF6E" modified="2016-11-02" version="1">MCGVYVCLSYTWGLQNTCVTTPDSLQSNLANIPYDQLPQTYKDAVTVALALNFPFLWIDSLCVIQGDEDSVDWKEQSSQMADIYGNAELVIAAASCTSVGDGFLSTARHSRDLIKFERHQNTQPRLELGWSTLAEPKAEGTLSRSWCFQEECLDEGYRCECAFSAAVSSLGLVTIKELYEPRLELGGPYETPNWMWQSTVEHYTRRRLTALSSVARVAQLALRTRYVTGHWWDADFLCSLCWAPVCTEETERTFSADCYVAPSWSWAAHNGPVTMWILVVPATRDDDVGAVSSGRITVRRVFLGVAVDTKPREQPLGVMMRKREAITFSFDRPLGLTSAADKYFCWVACVLPGQASRRRKSDTYCLIVLRGKPEGLEHVCERVGFVDHEAVTNSTCMRFFEGYRKLYRIAVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWZ3</accession>
    <name>A0A1B7YWZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165090.1">
        <property type="nucleotide sequence ID" value="XM_018296728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWZ3"/>
    <dbReference type="GeneID" id="28860835"/>
    <dbReference type="KEGG" id="chig:CH63R_01753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01753"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="118" mass="13893" checksum="A513F4EBE412A077" modified="2016-11-02" version="1">MARSTSQAYRHFRTALALWPKDNLRPETQFNEIIQRGIERRYTTPNIVDEAKELKQVNALYALADDRFKKTFPLNGDLLRPASQPTYFQDLVRELEEAPTRGWLKNMSKKLSGMFRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXM5</accession>
    <name>H1UXM5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carotenoid biosynthesis cluster protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_05052</name>
        <name evidence="18" type="ORF">CH63R_07461</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-cis-phytoene + A = all-trans-phytofluene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30603"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:30604"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>all-trans-neurosporene + A = all-trans-lycopene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30623"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30624"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-phytofluene + A = all-trans-zeta-carotene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30607"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
            <dbReference type="ChEBI" id="CHEBI:28129"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-zeta-carotene + A = all-trans-neurosporene + AH2</text>
            <dbReference type="Rhea" id="RHEA:30611"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16833"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:30612"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000517">
        <property type="protein sequence ID" value="CCF32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157214.1">
        <property type="nucleotide sequence ID" value="XM_018302436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXM5"/>
    <dbReference type="STRING" id="759273.H1UXM5"/>
    <dbReference type="GeneID" id="28866543"/>
    <dbReference type="KEGG" id="chig:CH63R_07461"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07461"/>
    <dbReference type="eggNOG" id="KOG4254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR08696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="577" mass="64476" checksum="7D520BE6C49EDDAA" modified="2012-03-21" version="1">MSQLGEKPKTAIVVGAGAGGVALAARLAKAGFSVTVLEKNDFTGGRCSLMYQDGHRFDQGPSLFLLPQLFHETFRDLDTTLADAGVDLLRCETNYNIWFHDGELFKHSSDLAAMKTQIERWEGKDGFERYLKWLREAHTHYEISVKDVLHRNFGKFLDLARPGFVRHVVNLHPLESIWSRASRYFWTERLRRVFTFAVMYMGMSPFDAPATYSLLQYTEFAEGIWYPKGGFHQVVAALVRIGEKMGVKYRLSTPVSRVLTDGRRATGVELESGESLSADVVVVNADLVYAYGNLLPKTPTITDYTKSLRKREASCSSISFYWCMDRKIPELSVHNIFLAEEYRESFDAIFKRHSLPDQPSFYVNVPSRIDPSAAPEGKDTVIVLVPVGHLAESKGESGLTTDPKHWEDIVARARAAVIEIVSARTGCAPLSDFITHETVNTPLTWEDKFNLDKGAILGLTHGIFNVLAFRPRTRAEGLEDAYFVGASTHPGTGVPIVMAGAKITAEQILDDRGLSVPWARGFDGILKPQSQSPGNKKLDEVRYGYHFGSEEVAVLSVGLLLALIYFYMWPSLQPLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZ31</accession>
    <name>H1UZ31_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="5 14">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_05458</name>
        <name evidence="18" type="ORF">CH63R_07186</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 14">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 14"/>
    <dbReference type="EMBL" id="CACQ02000682">
        <property type="protein sequence ID" value="CCF33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156939.1">
        <property type="nucleotide sequence ID" value="XM_018302161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZ31"/>
    <dbReference type="STRING" id="759273.H1UZ31"/>
    <dbReference type="GeneID" id="28866268"/>
    <dbReference type="KEGG" id="chig:CH63R_07186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07186"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_1_1"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12 14" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="16">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR08421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="154" mass="16003" checksum="D57836E4560F8B9B" modified="2012-03-21" version="1">MVKAVAVVRGDSKVTGSVVFEQESESAPTKITWDITGNDANAKRGMHIHTFGDNTNGCTSAGPHFNPHNKGHGAPEDEDRHVGDLGNIETDAQGNSKGTVTDKHVKLIGPESVIGRTVVVHGGTDDLGKGQNEESKKTGNAGPRPACGVIGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZC6</accession>
    <name>H1UZC6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05539</name>
        <name evidence="2" type="ORF">CH63R_13937</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000715">
        <property type="protein sequence ID" value="CCF33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151229.1">
        <property type="nucleotide sequence ID" value="XM_018308911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZC6"/>
    <dbReference type="STRING" id="759273.H1UZC6"/>
    <dbReference type="GeneID" id="28873018"/>
    <dbReference type="KEGG" id="chig:CH63R_13937"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13937"/>
    <dbReference type="eggNOG" id="ENOG502T1M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037438_1_1_1"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43311" checksum="00A276FDB7B3D5AA" modified="2012-03-21" version="1">MPQQPDAHLESLPTEVVLQILTQIGDVHCLWNLLISSPVASRVFNQYSDDIFWPSVTDGITPSQTQDAVRCIVSLRAGAFRSTPLDQLVGKIRDREAGIVLGQSLDLGYSISTMDTTAKPSLHVMRSVLAVASQVHALSRVCIGHYLAKLVAAKTDGRLDAAPEWLDDFRPSWIEEQRITRAFWRVQLVLELKMAARTSLVQSPVDRDGAPEELDIESFYDSDTSNLKVAYHEVMTAMEFLKGLGFCGDPDPTRPIGRLPLPTHSQMDIPPSMVRMPANSVTRRSSLVLPADGLWIVDSMARNAHSPIKYAGFRPYRNMGFAIWDRERLARMGLASPPGNGRVTGLGSYFPCWLSLLNPQEMAQAEGKMKEAECRGGRLDPLQPMIQDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V008</accession>
    <name>H1V008_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallopeptidase MepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05720</name>
        <name evidence="10" type="ORF">CH63R_01450</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000805">
        <property type="protein sequence ID" value="CCF33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164787.1">
        <property type="nucleotide sequence ID" value="XM_018296425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V008"/>
    <dbReference type="STRING" id="759273.H1V008"/>
    <dbReference type="MEROPS" id="M03.009"/>
    <dbReference type="GeneID" id="28860532"/>
    <dbReference type="KEGG" id="chig:CH63R_01450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01450"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_1_1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000074">
        <property type="entry name" value="Metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="223"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="723" mass="81409" checksum="AA9409EE5F1BD6BC" modified="2012-03-21" version="1">MSTRHPPQKPPVFTITPTGIITEINRLISASQAAQQAITHSVTTSNATYDKVLLSLSRAENALAAESTLLLFHNAVSPSPEVRDASARARSALREFELECSMNEDLFRLVDAVYNNSGEVQGLGPEARNYLNKKHKEFVKNGLRIPAGPERDRFKEIRSRIESLTSEFSKSLAEADVSVWFTPHELDGYPQDSLARLEKGESGGENEGKLRIRIPNHLAPVLRTVCNSETRKSARLAYENRCPENVAVFREVVVLRHEAARLLGYTDHASLSVEDKMAESPRRVDAFLSSLRSKLAKAGEAERETLVRLKQRDVEARGETFDGRHFFIWDVPYYRNLLSREQYSVDHETISEYFPLQATVGGMLRIFEHLFGMAFHEIEGDERDRLSSTGKGDDLVWHPDVQILSAWDAESEGSGFLGYLYLDLYQRDGKRGNPANFSLIPGFTNPDGSRTHPSTALICAFAPPPSAHQPTLLRHSDVVMLFHELGHGIHDLVSRTQLARFHGPMGTVVDFGEAPSQMLENWCWTPTQLRGLSRHYSYLSEACLKDWRARVGQEDARQPPEKIPEDVVEGLIEARHAGQMMGTLHQLFISIFDMAVHQLAGQDAVDSVDFTQLWNRLRREIVPTDDPSVLGEGDGWGHGYTNIGHLMDEYDAGYYGYFFSKVYAQDIFTNVFKEAPMSQGAGRRYRYGVLEKGGSQPEMKTLTDFLGRDVRMEPFYEDLGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V080</accession>
    <name>H1V080_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01006</name>
        <name evidence="7" type="ORF">CH63R_03437</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000835">
        <property type="protein sequence ID" value="CCF33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163228.1">
        <property type="nucleotide sequence ID" value="XM_018298412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V080"/>
    <dbReference type="GeneID" id="28862519"/>
    <dbReference type="KEGG" id="chig:CH63R_03437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03437"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="246"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="432" mass="47045" checksum="57C01C9ED3959734" modified="2012-03-21" version="1">MSVELRRLPDADARAASAQQTDEEDVNTLIQTMPPTDKGAAAWKFLLSSFVIEALLWGFPLTFGVFQEYYSSQPQFKDDPNIAIIGTVSTSIYFLGAPLAAPLVKRFHLYQRHMVVVGWALCVASLVGASFADSVPGLIATQGVLYGFGFLMLYFPVLRMLNEWFVARRGLAYGVLYAGGGFSGVGLPFLLQLLLSRYGYRTTLRAVAVAQFACVAPVLHMVKGRLPPSPRGAMRMFDVSFLRQPLFYCFALSNLFQGFAYYIPSLYLPSYASAIGLSGTMGALLLAAHNLATVFGQLGFGWLSDRTDNVFALMFVSSFVSSVAAFTLWGFAHSLALLVVFALVFGMFAGGFLIFWAKFGAMLSDDPQPVFSMMAFGKGIGNLATGPITAGLLTKPVSWGYGMGRYESLILFLGSFMLCSSLGAFAWPLKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0C0</accession>
    <name>H1V0C0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_05816</name>
        <name evidence="19" type="ORF">CH63R_04620</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000850">
        <property type="protein sequence ID" value="CCF33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160841.1">
        <property type="nucleotide sequence ID" value="XM_018299595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0C0"/>
    <dbReference type="STRING" id="759273.H1V0C0"/>
    <dbReference type="GeneID" id="28863702"/>
    <dbReference type="KEGG" id="chig:CH63R_04620"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04620"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031067_2_1_1"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04757"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF33671.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12324.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="440" mass="48969" checksum="5FB7584BD8AD7D77" modified="2012-03-21" version="1">MEFMTALRGSFDDQKPSLFELISEQQLNSLLPPTIRYLLTIATQRYPRYLLRALNSFDELYALCMLVVERHYLKTRGGSFTENFYGLKREKALHAEIPRASASAPGVVRDTLKLSTRDVWMNLAVVVGIPYLRRKLDEGYEVNAPRALLGAAYTQMPPNPTLKQRFLHYYRWFLRNVYPSVNAAYYFALLSFNLAYLFDNSKYHNPFLWLIGTRMRRMTGADYQAIDALTSGKPTGSARAGAPPGWRSLFSPREMGPRLLSSLSMLLPMSIFALKFLEWWHASDFAKQLSRKATETLDLPPPVVSGLGGGKGGAGAEKEKSKAKEKAASGGNDDEAATAVPAAETAPIATPSLLPIYTVAAPEDSSLCPICQDAIVTPTACQTGIVYCYTCIHRWLEGLHPMQEDFMGDKEGKWESGQGRCAVTGRRVLGDTEGLRRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0Y6</accession>
    <name>H1V0Y6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05988</name>
        <name evidence="2" type="ORF">CH63R_00132</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000931">
        <property type="protein sequence ID" value="CCF33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163469.1">
        <property type="nucleotide sequence ID" value="XM_018295107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0Y6"/>
    <dbReference type="STRING" id="759273.H1V0Y6"/>
    <dbReference type="GeneID" id="28859214"/>
    <dbReference type="KEGG" id="chig:CH63R_00132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00132"/>
    <dbReference type="eggNOG" id="ENOG502QSJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045155_1_0_1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38498" checksum="FF0F177C75FBEC12" modified="2012-03-21" version="1">MAQVSSATLSPLANLTFKPIINDDLRPAPAAKPETFNPDKHLAFVNDPNRLTLQDLSLPEDVGISPVACSEPFPLFTQEAIQIMRQEIFTTEVWDNCLHSTQFAPCQLRGHCPKYAPFMDQAWNDPQTLAIISKIAGVDLIPNIQYEVGNINISIQNAVGDQKEVHAKSSDSNSVTKWHYDAFPFVCVVMMSDATNMVGGETALKTGTGEILKVRGPQMGSAVVLQGRYVEHQALAALGGTERITMITSFRPRDPCMKDDSVLTSIRPISEHSELYYQWVKYRVEVVQERMKVMLKDLEERHDAGSRTDIPAVKKLLAQQEEYINTTNREIVEDLEPLRAWEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1Y0</accession>
    <name>H1V1Y0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06265</name>
        <name evidence="3" type="ORF">CH63R_06702</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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                <person name="van Themaat E.V.L."/>
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                <person name="Hansen M."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
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                <person name="Kubo Y."/>
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                <person name="Will I."/>
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                <person name="Zhou S."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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            <fullName evidence="4">Copper homeostasis protein cutc</fullName>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF36043.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
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            <begin position="38"/>
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            <begin position="825"/>
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        <source>
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            <dbReference type="EMBL" id="OBR13995.1"/>
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            <dbReference type="Proteomes" id="UP000007174"/>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9H3</accession>
    <name>H1V9H3_COLHI</name>
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        <name evidence="2" type="ORF">CH63R_03431</name>
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    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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        <property type="protein sequence ID" value="CCF36876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03431"/>
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        <property type="component" value="Chromosome 2"/>
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        </source>
    </evidence>
    <sequence length="797" mass="88937" checksum="1BF9A8415F26B1FE" modified="2012-03-21" version="1">MADNVPREPATTAAPIPPLVTLTECRWRWKGRLYDTSEIPKDFVFGVQPLERVILPRDADNMVVLGALKRAHRRYKTDINLSEDSYYAGVEGGLFVPVFIRLHGSSADPNMDNSYSGVMFGNGATNKRGGLIVPPVDMLRPRQLAFLKTQSLGPEFLPKGTIPFRQVSRGEREQHLRNQQEAFSTGQPCPVLVEDPAAKPDYHVFQHLKVGNWEPFMMDMPKLDSIRVPKSLVDEVESFLAKYPRDIVPVNLAVSMAIAWAAYCNTTEYQPELASSKRRRPPIPPSLTGDLVRPVPYVDLAVLILYSTHYFRLHEEHGLSAYAHIFRVVSALYAKDTQFNEAFKIDPDDIDHGFVFGCVRALNLRDEDWEEIVPPSFDGSRLVMPLNCGTRRPPSPELTATLMMPDIYTLGFPGYTNEGRKGHGDVMRRVMMHRTWVPQHILDRNEGDPLDQEYLGLESVTPYRDQDRHQLWTAPVTEVRSPFPRITGAAIDTLAFLSKKVDNKLQKKPVGTPNAGNCNVTNANQLVCSRKSVVDIFTDYFRAHIADLRMAQDAGHISELVTLGPDGYLAWPLRSDRDVDAPTLPREIDIGQLLAEDAARNDPLSAEDRLLLKTIVERDLAGDKHVARCLEPLRLLDINDPGLSKSRLRGVLVAAVRPVREMMDRVLSYSNSVRDDDNAEVAAFVDELVKPCCGLLGLGAGGSLVQCMEAIHGAERELHAVLTNVGFVVKYQRGNADFFRVAMGLVTGAACFGYLSRLALLYDRLSGIPVEMADEKKKMMAWESVFRLAVAGEDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFJ0</accession>
    <name>H1VFJ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_09942</name>
        <name evidence="6" type="ORF">CH63R_07000</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003253">
        <property type="protein sequence ID" value="CCF38993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156753.1">
        <property type="nucleotide sequence ID" value="XM_018301975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFJ0"/>
    <dbReference type="STRING" id="759273.H1VFJ0"/>
    <dbReference type="GeneID" id="28866082"/>
    <dbReference type="KEGG" id="chig:CH63R_07000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07000"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF38993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="358" mass="40000" checksum="96B25A967A1FABB1" modified="2012-03-21" version="1">MAAPPLPTSLQKSLDATKVEYVNLGASGLRVSVPILGGMSLGSSEWMDWVLDEEESCEVLKAAYDRGINTWDTANMYSNGVSEVVIGKAIKKFNIPREKLVLMTKCAIHVGEETSMFAPMYAQQLAQSKDYVNQGGLSRKTIFKAVDDALARLGTTYIDLFQIHRFDPTTPVEETMKALHDLVQAGKILYIGASSMWATQFAQMQFAAEKNGWTKFVSMQNFYNLVYREEEREMNRFCRDTGVGLIHWSPLFGGALARPLEAEKTSVRSQAKGLMNPDLTEVDENIIRRVGELAQKKGWSMSHVALAWIRSKGGVPITGFNSIKRIDEAGELRGKILSEDEVKYLEEPYVPKNIVGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGW2</accession>
    <name>H1VGW2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_02137</name>
        <name evidence="6" type="ORF">CH63R_12220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003512">
        <property type="protein sequence ID" value="CCF39465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154035.1">
        <property type="nucleotide sequence ID" value="XM_018307194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGW2"/>
    <dbReference type="GeneID" id="28871301"/>
    <dbReference type="KEGG" id="chig:CH63R_12220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12220"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF39465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="47762" checksum="5728093D1D8354DF" modified="2012-03-21" version="1">MSLSPIHLTEKDTNVEPKRTDSSPPGDLVQHQAAALDPEATPTPEPAAKPDGGFVAWMQVVGGFLLFFNSWGILSAFGVFQTTYESGTLFKQSSSNISWIGAIQYCIAMMTGFWAGPVYDRGYMRVLLVIGTVCVVVGHVLLSFCHPYWEVLLAEGFLIGTGAGCLFLVCISTLPQYFDKNLGLAAGIASSGSSFGGLVYPVALYHLVDHVGFSWAVRVVGLIALATLMVPLFAMKARGKPGRPRSFVDWTAFKDGRYMTFVAGTMCGSASVLILNTYISYFGKNEQLLDGPMSFYIVSVFNAASCAGRILPNFISDTLGPFNILAPFMFITGAAALCMTAVHSEGAIIAMAVVLGFLSGVFPSMPPVCFARLTKDKSKIGTRMGMGYSMSSLGYLAGAPGAGAILGSVAPLQWTGLWVYCGMASFASGLIYAAIRISNTGWKIRIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VHL2</accession>
    <name>H1VHL2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf962 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10473</name>
        <name evidence="3" type="ORF">CH63R_00571</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003652">
        <property type="protein sequence ID" value="CCF39715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163908.1">
        <property type="nucleotide sequence ID" value="XM_018295546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHL2"/>
    <dbReference type="GeneID" id="28859653"/>
    <dbReference type="KEGG" id="chig:CH63R_00571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00571"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="195" mass="21103" checksum="82239E129FC1FB24" modified="2012-03-21" version="1">MSLDLEKHLTFYGAYHHNTVNIGIHMACVPLILFSGFCLATNTGTLIPLPSWLTVPNLELNLGTLAALTWGGLYVLLEPVAGTLLAVICLAATAAGNSFRLQNPALTNQAAIGVHIACWIFQFIGHGAFEGRAPALLDNLVQAVFLAPLFVWLEFLFKLGYRQELKGRVDKAVEKEIAKFRASKANGDAKNGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJI3</accession>
    <name>H1VJI3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin ccl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_10964</name>
        <name evidence="6" type="ORF">CH63R_13432</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004047">
        <property type="protein sequence ID" value="CCF40386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152823.1">
        <property type="nucleotide sequence ID" value="XM_018308406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJI3"/>
    <dbReference type="STRING" id="759273.H1VJI3"/>
    <dbReference type="GeneID" id="28872513"/>
    <dbReference type="KEGG" id="chig:CH63R_13432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13432"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_1_1"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF40386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="374" mass="42010" checksum="9D91CAA3E86B7B24" modified="2012-03-21" version="1">MATEDARYRLSTQYRLWSFSPSKLAELREQTNSLARTHIASRLIETKRVDIDVEPLPEFLTPAEEIQLLKVFTVDLIRAADFCGMPTEVRATATVFLRRFYVTNSIMTYPPQDVLKTCLFFGSKAEGQYMRLAKLAEKFPNTTEEEILAGEFLLCQGVRFAFDVRHPFRALEGAILELRRHTDLEKARIDTAHARARAVLKFSSLVTDAYFHYTPSQIMLAALSLADRGLTERLVQGAFTPNQNATSNENGTDSTPRHELRDKVMGAIEACREMLATEPPERLDEYWGTPESTKLIKPLLRKLKKCRDPDRADLVALQKARRELASQKESRRPKAEGDGAVFSGDGGGLNGNDARDAKRRKVGEGDDVFGPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK44</accession>
    <name>H1VK44_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_02391</name>
        <name evidence="8" type="ORF">CH63R_13976</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004179">
        <property type="protein sequence ID" value="CCF40597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151268.1">
        <property type="nucleotide sequence ID" value="XM_018308950.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1VK44"/>
    <dbReference type="GeneID" id="28873057"/>
    <dbReference type="KEGG" id="chig:CH63R_13976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13976"/>
    <dbReference type="eggNOG" id="KOG3572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000935_0_0_1"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1374"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="892"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1471"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1899"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="812"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1899"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1949"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF40597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1959" mass="216188" checksum="6DE1D5331A430E2D" modified="2012-03-21" version="1">MPRNASATPSLRKGPNWSSHLRQFSRSSLDPPSATSSVDSPQSPDTVSSASTIRGDNSSSSVKQRRLERRCTVTVNEGYSRDEVLLSPDLVKGDVRPGSLVAITVLKTEGDKTATKDHAPRGGTAAGSSSSVGAGAGGSSQGDNAAAEGVVLGKKYFFVAKEMSKELRARLPNVDIYVVKHIADAFGMKKGTQVLLTPVDADSPATAASHVELSFKDQYLSRSDMWRLAIGELTERTVYKGQSILFMGTIKAQVTAVYVDGSKTHSAFFTRNTRPIFRSESARYVLFIQMAREMWDFDSEGSGEILFNKVVNGFLPALFKKWAKLKAKHLVSIVLFARVEYDTGLTTELASSTLHGDYYTGVQISGERRPYKDFYRVVVSEMASGEWTTILYQLKREFNFFRRDISLHHQKAGSAFVPLAEETGGKGITSNRVKAESSLAMHGNFLEAINLASSQFAHDYVDRDLMRTGISIAVISPGPGVFEVEYESLRRTTEALVGNGIGIDLICVPKMPLHSVPLFRYRNPQTSEGSHGLSRTRSVRSRESTPKQQATPVIGSYQSLSESLSPTKGLELAHRIDTLANPQDEWSYALPQWLHVSYWTGTSEEALSYQGIALSVSENKEEQESDEFAIRARMYDLQMRSVLETNEIETTPLQADPLFPITTAESKSSSQRSRLGGTDEVAVIPLRRHMDTLVDHVYGFQKFMPDRLVKPGEKSLWKQLQEYDDTRARLPKSRRPAHARASRDLEETTRRQLMEDAGLFGTSLPEKKIVPNQSLAAVTSGRKLSVNIGDSEKADIVAAARKATYHHPQTTANSAGGPTPSSASSSTPDSRSVTSNKASSASSLAKPPRFMRQISLGLRGFGIAAPKVVAAEASFETVKASTEQSVLSPTTPLVMSTLPRPSSPQVIKPAATASPSSFSPKLFRSDSRDTLKDLPSTPSIPINMKSSRRGESSVGQQHRYGSVLPPSLARKDNFREDPDQRNSHVLRAEDDNTKMFNSKLRAGVMPELPSTLSPTTAISPWLTVLNPSNPDRNKVDDTVLYSRWQHVFPRTSEMKVMKWKALCCPAAVPLTTEYFPTKSQFDMEYQRQPYVIAQNADDELTEEPKSREEFLRELISLRFSQGFQVVIGPSVAKAFGQRLLRIADIFSRGQAMEDGTSIFLSVGNTIHQLSCVNGTEVEVNIYIRKPAESTIGHSNSGPLYRPAIRTLMDRGYRTQEVDISTPRPERNWNYIDSYLAGHHDEMTENLRFWRARFVLIPMVSRSSAVPRNQAGDNAEEVRLEGIRRLSLSWQKYRYIPPFERRYQTAKSKRDPNPLDIVYKTEDPSVVIAAELDNLPLVEGMGESRRGQLISSREHFRKSNLNLAALAEAIQQPVENGGVKLQNRRWHLRLHYNCFIGSDMTTWLMDNFEDLDSREEAEQLGNMLMVKTYDRSDDRKDRGGLFEHVEKRHAFRDGQYFYSIASEYAKPHPPGWFNSRRRDVSVPSTPMSENLPRDSPRPGIISRPTSINEENSPISGSTTPTAYSVMLNNKKMPKVVLSKVIKYDVDHRKRSYRPERVDLHYDRLHNPDNCYHIRIDWMNVTAKLIEDVVEGWAREAATYGLRLVEVPIKEACAITDVNPFRRPYIIKLSVPPPSQQPVTYYEPNSFTPQTAPGKHFYQKAIMRRLDFVLDMEAASNYPRDVEVSYSWGRPDFKYSQYIHRSGVLLAEITDDGDFLVLANRLFSNRASAARDKELKDMREANGGGGGGGGRIIPVGSYTPFGIPEPTPMNSPMVKPLFYAGGSPAVRASDMKSGANSSTGTIGGGGGGASGLGAGAADPISLLEHLEAFCSDGAGLEAFYKETLERGPPQAMTTPGAMRPTTMGLEAVPEASIPMLGLPAGVLGDVHSSGPGGGLEGMRGVVGGGGPEGLRGLGGSPSPGPRSLMSSPAAGMQFLRRASVQDGLGLGGGGPRREARERERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKB7</accession>
    <name>H1VKB7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_02407</name>
        <name evidence="9" type="ORF">CH63R_05805</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02004223">
        <property type="protein sequence ID" value="CCF40670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158630.1">
        <property type="nucleotide sequence ID" value="XM_018300780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKB7"/>
    <dbReference type="STRING" id="759273.H1VKB7"/>
    <dbReference type="GeneID" id="28864887"/>
    <dbReference type="KEGG" id="chig:CH63R_05805"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05805"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="55185" checksum="2CBA3121D74FA498" modified="2012-03-21" version="1">MDAIKSVLNIGSGKPAATEPSAEQLAQLKEKYAKAGQDQVFTFYDELPTSEKATLFQQLSGFDPEHINKITDRALNPPKTDDASAQSGLEPLPESATASILDSKPEDIENWYQSGLDLIGQNKVAVVLMAGGQGTRLGSSAPKGCYDIGLPSHKSLFKIQAERIRKVQELAAKKAGTSSAVVPWYVMTSGPTRGPTEQYFQENNYFGLDKANVLIFEQGVLPCISNDGKILLESKSKVAVAPDGNGGLYQALVVSDVMGDMRKRGIEHIHAYCVDNCLVKVADPVFIGFSASKDVDITTKVVRKRNATESVGLILLKNGKPDVVEYSEIDQETAEAQDPKQPGVLKFRAANIVNHYYSFRFLESIPQWAHKLPHHIARKKIPYADLKSGETIKPEKANGIKLEQFVFDVFPMLELSKFASMEVKREDEFSPLKNARGTGEDDPDTSKRDIMLQGKRWLEAAGATVTGETTEVGVEVSPLFSYSGEGLEKFNGKEIKAPAVLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRI4</accession>
    <name>H1VRI4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH063_00446</name>
        <name evidence="23" type="ORF">CH63R_07801</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005679">
        <property type="protein sequence ID" value="CCF42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157553.1">
        <property type="nucleotide sequence ID" value="XM_018302775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRI4"/>
    <dbReference type="STRING" id="759273.H1VRI4"/>
    <dbReference type="GeneID" id="28866882"/>
    <dbReference type="KEGG" id="chig:CH63R_07801"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07801"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040829_0_0_1"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR09036.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="397" mass="44876" checksum="60B6E56C4205D5F0" modified="2012-03-21" version="1">MAPRIEAQEIETYWNIFSARTGGGQFLTGEQAAPVLKNSGLTDNQLERVWDLADVDNDGNLDFEEFCVAMRVIFDILNGEYSDVPTTLPDWLVPESKAHLVQANRALAGKQVAFEQVEDDPDSPGLKDGFDWYMTPQDKAKYESIYQENRDARGEVAFSSLEDLYESLDVPDTDIRSAWNLINPSAGPSINKDACLAFLHILNNRHEGFRIPRTVPASLRASFERNKIDYQLDNQAPGASRWATKADESTATGRKAKFGDQYLTRLGRSGFKTSGTDFSTAKTDDWEEVRLKKQLQELDEKMARVEADVERKKGGKRDSKPALVKRELEQLLDYKRKELRELEDGTGKAKGGASLKSVSEDLQTVREQVEGLETHLSSRQHVLEQLRREIEDEKLSR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
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    <name>H1VRR1_COLHI</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005731">
        <property type="protein sequence ID" value="CCF42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018302019.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VRR1"/>
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    <dbReference type="GeneID" id="28866126"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07044"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <end position="37"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR08279.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005835">
        <property type="protein sequence ID" value="CCF43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018295136.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VS62"/>
    <dbReference type="STRING" id="759273.H1VS62"/>
    <dbReference type="GeneID" id="28859243"/>
    <dbReference type="KEGG" id="chig:CH63R_00161"/>
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        <location>
            <begin position="460"/>
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            <begin position="1"/>
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            <begin position="17"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSR7</accession>
    <name>H1VSR7_COLHI</name>
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        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_03031</name>
        <name evidence="11" type="ORF">CH63R_03057</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005979">
        <property type="protein sequence ID" value="CCF43275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162848.1">
        <property type="nucleotide sequence ID" value="XM_018298032.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759273.H1VSR7"/>
    <dbReference type="GeneID" id="28862139"/>
    <dbReference type="KEGG" id="chig:CH63R_03057"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03057"/>
    <dbReference type="eggNOG" id="ENOG502SR0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133934_2_1_1"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="43"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF43275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR09581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018303320.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="28867427"/>
    <dbReference type="KEGG" id="chig:CH63R_08346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08346"/>
    <dbReference type="HOGENOM" id="CLU_2722094_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
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    <accession>H1VTU3</accession>
    <name>H1VTU3_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <organism evidence="3 5">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006264">
        <property type="protein sequence ID" value="CCF43651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158688.1">
        <property type="nucleotide sequence ID" value="XM_018300838.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VTU3"/>
    <dbReference type="GeneID" id="28864945"/>
    <dbReference type="KEGG" id="chig:CH63R_05863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05863"/>
    <dbReference type="eggNOG" id="ENOG502R9KK">
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    <dbReference type="OrthoDB" id="5302254at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="APC_suCDC26"/>
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    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="20552" checksum="0E2E37254F044D9E" modified="2012-03-21" version="1">MLRRPATTLGITAEDIAAYEDRRARESMLRERQVLVQAQQQQQQQQQQAALAAQQQRILRQQPQSQQQPFSSPQPLHQQPQQQQQRYTQAQLQQMQRLQQQQQQLEDESMLTAEGDDEDESLDEYELLRRQQEMMRAQRGQQQHGRIGGLQTTPTPGDGGRGGRTREERIGVGRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWF9</accession>
    <name>H1VWF9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_13924</name>
        <name evidence="6" type="ORF">CH63R_01947</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006995">
        <property type="protein sequence ID" value="CCF44571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161738.1">
        <property type="nucleotide sequence ID" value="XM_018296922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VWF9"/>
    <dbReference type="GeneID" id="28861029"/>
    <dbReference type="KEGG" id="chig:CH63R_01947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01947"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019225_1_0_1"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000258">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein (AFU_orthologue AFUA_6G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF44571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="591" mass="65961" checksum="DADD9AEAC0904E56" modified="2012-03-21" version="1">METLDFVVIGAGWYGLAAAKTHHKLHPQNSLALFEQASSAGGVWAEHRLYPGLKSNNMLGTYEYPDFPMDPETFGVLPGQHIPGQVLHDYLTKFAETFGILDKIRFHHKLLSAEHQTNGGWLLTVLNGKDGKEIQVLAKKLVVATGLTSEAFLPNFDGQETFGAPIFHGKDFLQHADTLDSAKSVTVFGGTKSAWDLVYAYAIKGIKVNWVIRESGHGPVWMAPPYVTPLKKWLEKLVHTRALTWFSPCSWGDADGYVKTRNFYHGTAIGRGITNNFWSVLGNDVITLNKLDSHPELKKLKPWSEAMFTASSFSILNYETDFFDLIRDGTVDVHIADLTKLSPSTVHLSDGSSLKSDALCCATGWKQFQPIKFLPEGIEKDLGIPHAPSADSFPPAEMTEAIDREILDRWPRLGDQPVQNKKMKPLVENEGVSTTDAVNPYTPLTPYVLHRFMVPPSSKLLAHRDIAFAGVLMNFTVAMISHVQSLWIDAYFHDQLPSVREAASDPQALQKLRYETALHSRFCKWRYPAGHGDKFPDFVFDAVPYIDQLVGDLGLKVYRKNGMIAEASEPYGPDDYKTLVDEWTEKQAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VX26</accession>
    <name>H1VX26_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_03426</name>
        <name evidence="9" type="ORF">CH63R_12880</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007179">
        <property type="protein sequence ID" value="CCF44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152271.1">
        <property type="nucleotide sequence ID" value="XM_018307854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VX26"/>
    <dbReference type="STRING" id="759273.H1VX26"/>
    <dbReference type="GeneID" id="28871961"/>
    <dbReference type="KEGG" id="chig:CH63R_12880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12880"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034385_1_0_1"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="106"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="465" mass="52161" checksum="E1BE4CE78B2BEDC2" modified="2012-03-21" version="1">MFSNRKFSINRHTGVPKPRRFSVGEIGGNEVQSKTHRQFRNAHEGHQPHAGLDASRASTGVVWCTERASEYGFLEDPDSWANLGQGAPEVEDDIAGCFPRPTTIDISMAGREYGPTAGIKELREAVANLYNVMHREGKDSKYTWENVAIVPGGRAGLIRIAAVLGNSYLSFFLPDYTAYNEMLSLFKNFSAIPVPLAEEDGYHIHPDRIAEEISRGSSVILTSNPRNPTGRVVANPELAEIQDICRGRATFISDEFYSGYNYTSNCDGNTISAAENVEDVDEDDVLIIDGLTKRFRLPGWRIAWILGPKEYIKAIGSCGSYLDGGANHPFQEAAIPMLDPTLVKAEMVFLQKHFRDKRDYVVRRLREMGFIIKYVPDSTFYLWLNLEGLPGPIADGLNFFQACLEEKVIVVPGIFFDLNPSRRRDLFDSPCHHFVRFSYGPKMETLKKGCDGIERVVNKFRKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYI2</accession>
    <name>H1VYI2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03566</name>
        <name evidence="3" type="ORF">CH63R_06457</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007612">
        <property type="protein sequence ID" value="CCF45294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159282.1">
        <property type="nucleotide sequence ID" value="XM_018301432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYI2"/>
    <dbReference type="GeneID" id="28865539"/>
    <dbReference type="KEGG" id="chig:CH63R_06457"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06457"/>
    <dbReference type="eggNOG" id="ENOG502T4AE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633142_0_0_1"/>
    <dbReference type="OrthoDB" id="4833950at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="433" mass="47249" checksum="FF13DADD00924708" modified="2012-03-21" version="1">MTTYDFYADADWASLSRWWPLFEAQDDPDKNTPPDMTCSAISPTSTLINTPEMQPMPVSCSSTPSGHCRVQGLASCLRAMDDKTFSWNFKSLSATALDQALMQGPHFLSMSHSCCGNTLLSLVVAQGCSVDTMGFLLSRTRIREEHGYRISDFVEELGRAIVTLVTNSRTRCVGNCLPGDGKKCLYLLLRAATLNSFAKTNWYHTGKMRAWLLETFEVACAWKSAPAANADPELSDTKTSYPAPIPALLDFAECIIELLDYHNGPDGIFDATLWTGILKCLWTHERITKGTLTRVTNVTLRLLSLGASKEIELPGTVKGGNFLACVKSGLSPDEGADPNLDDIDVKIDEKHVRPTSVTDSFLAIEWELLLRKRQENIVKLQTIILGADSTSSASPAATVMGVAIDADLSGTEAQPNDSKENDDARSSVLHGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ46</accession>
    <name>H1VZ46_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5-like Heme/Steroid binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_14566</name>
        <name evidence="5" type="ORF">CH63R_10435</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007809">
        <property type="protein sequence ID" value="CCF45508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154833.1">
        <property type="nucleotide sequence ID" value="XM_018305409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ46"/>
    <dbReference type="STRING" id="759273.H1VZ46"/>
    <dbReference type="GeneID" id="28869516"/>
    <dbReference type="KEGG" id="chig:CH63R_10435"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10435"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070889_0_0_1"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="106"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF45508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR06315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="30840" checksum="6315CAF074218CC2" modified="2012-03-21" version="1">MADESPSVRQRKPVQQAEDDDNLFAGTPAEHSRGKKSKRSKKAKAEADVYSPYVDILRLLSFLLLASCALSYLQSNGESFFWGQKNKPWYLRPSYWRSKWNGPVYLTPEELLQYDGSDPEKPIYLAINHTIFDVSANPRIYGPGGSYNVFAGRDASRGFVTGCFMEDRTPDMRGVEAMFLPLDDPEIDRHWSYDDMRRLQEEELAAARAKVHDALKHWVDFFSKSDKYGAVGKVRRDPDWLEKEPKKKLCEQAQKGRVPRKLPGQEGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1V1</accession>
    <name>H1W1V1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_15202</name>
        <name evidence="6" type="ORF">CH63R_02961</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008717">
        <property type="protein sequence ID" value="CCF46464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162752.1">
        <property type="nucleotide sequence ID" value="XM_018297936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1V1"/>
    <dbReference type="STRING" id="759273.H1W1V1"/>
    <dbReference type="GeneID" id="28862043"/>
    <dbReference type="KEGG" id="chig:CH63R_02961"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02961"/>
    <dbReference type="eggNOG" id="KOG1698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076387_0_1_1"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF46464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="219" mass="24860" checksum="947A1E03F8585A8A" modified="2012-03-21" version="1">MNATCLWRPIGCLKTALRQTRHQRLLTRSMATAPAAERPASTPSHSRPLTKPSYFGPRDKPTFAVYPPLPSVRHTHKDPLPALDAQQRSTLDATGARTRLFDPARPDSAKVGDVLMVTTKSGEPFSGVCMSIRRRGVDTAILLRGQLMKVGIEMWYKIYSPTVIGIDIVWRRPKRARRARLTYLRKPKHDMGSVDHLVFAWKKERYGMRNRGKQVGTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2B1</accession>
    <name>H1W2B1_COLHI</name>
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        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03918</name>
        <name evidence="4" type="ORF">CH63R_07421</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008889">
        <property type="protein sequence ID" value="CCF46624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157174.1">
        <property type="nucleotide sequence ID" value="XM_018302396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2B1"/>
    <dbReference type="GeneID" id="28866503"/>
    <dbReference type="KEGG" id="chig:CH63R_07421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07421"/>
    <dbReference type="eggNOG" id="ENOG502S9V3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_2_1_1"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
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    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
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        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF46624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="179" mass="19643" checksum="A4C90AEF988A351A" modified="2012-03-21" version="1">MARGRKFFPSHKFIISCGTVTVDMRARRVLLIFNKRHRIYQLPKGRKDIGEDLLAAALRETREETGVVARAVTLRLRTRATPTGGPPGAPEVSEEVADTEPVAVCHYPDPASGAMKMVFYFVAEGSCDLAQGGWTGEDRVKFDVVWVDVAAAADKLAFKEDGMVVDKALEDLRASGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4C1</accession>
    <name>H1W4C1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04126</name>
        <name evidence="4" type="ORF">CH63R_05575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009601">
        <property type="protein sequence ID" value="CCF47334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158400.1">
        <property type="nucleotide sequence ID" value="XM_018300550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4C1"/>
    <dbReference type="GeneID" id="28864657"/>
    <dbReference type="KEGG" id="chig:CH63R_05575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05575"/>
    <dbReference type="eggNOG" id="ENOG502T4P9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517766_0_0_1"/>
    <dbReference type="OrthoDB" id="4849762at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555707" evidence="2">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="181" mass="19744" checksum="5D5BA891A6DB6C0A" modified="2012-03-21" version="1">MAKIFNLVSSALFALLFLQLAAAQGAAPPQDAPSAPVTCVEAPQDKWLVTQKWKKFSFQSLGVWYANVPALGSQPQRRSSLIERRKKKNKDKEEENTPEEQPQDQGQGQAQGTGADCTFTQLIPGGDGTLQFTNTASYRQVVCVTTVLASDKIKCYWLNAGDSCTTATSTQWLLFSAGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5R2</accession>
    <name>H1W5R2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH063_04298</name>
        <name evidence="21" type="ORF">CH63R_04259</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02010189">
        <property type="protein sequence ID" value="CCF47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160480.1">
        <property type="nucleotide sequence ID" value="XM_018299234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5R2"/>
    <dbReference type="STRING" id="759273.H1W5R2"/>
    <dbReference type="GeneID" id="28863341"/>
    <dbReference type="KEGG" id="chig:CH63R_04259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04259"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043308_1_0_1"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="174"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCF47826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="400" mass="44402" checksum="BD89776C58925556" modified="2012-03-21" version="1">MADEVAEVRTEGPDGGEEQEETALATTNSEVTAPAERKVKKIIRKKKRPARPQVDPSFITSEPPPQTGTIFNIWYNKWSGGDREDKYLSKTHAKGRCNVAKDSGYTRADRVTGSYFCLFFARGICPKGQDCEYLHRLPGIHDIFNPNIDCFGRDKHSDYRDDMGGVGSFMRQNRTIYVGRIHVTDDIEEIVARHFAEWGQIERIRVLNTRGVAFITYSNEANAQFAKEAMAHQSLDHEEILNVRWATADPNPMAQAREARRIEEQAAEAVRRALPAEFVAEIEGKDPEARKRRKIESSYGLEGYEAPDEVHFAQGVNAVNPVGREGHAVEYQERPMLENGDQQQYQALPALQGQSIVSGGIFSSSTLAALNASKVAVASKPKAAVSSGPLVAYGSDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5W1</accession>
    <name>H1W5W1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_00093</name>
        <name evidence="17" type="ORF">CH63R_02694</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02010235">
        <property type="protein sequence ID" value="CCF47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162485.1">
        <property type="nucleotide sequence ID" value="XM_018297669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5W1"/>
    <dbReference type="STRING" id="759273.H1W5W1"/>
    <dbReference type="GeneID" id="28861776"/>
    <dbReference type="KEGG" id="chig:CH63R_02694"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02694"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027974_3_0_1"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000056">
        <property type="entry name" value="CCR4-NOT core complex subunit Caf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="54532" checksum="DED1F8A20E566E76" modified="2012-03-21" version="1">MPPQLTRFPGGPNTISPYHQQFPSHAQGHGPSHGPPLGANPSYLNANAAQLSPFSTNGNVLGGTPGLNGGFPISADTGLGSHAARMGFAHAASLQQQQQQQHGQPQHSFALDHGAAPPRTTQNKGRIREVWKHNLHEEMAVLRELVDKYPYIAMDTEFPGVVSRPMGSFRGKSDYHYQCLRTNVDMLKVIQIGLTLFNEDGETPPARPNSQQDIELSAAQRRAASQGPFPYAWQFNFKFSVKDDMYNEKSIESLSSAGIDFASLERDGIDPHEFASLLIPSGLVCFDNVKWISFHGGYDFGYLTKLLTCNDLPNDEADFDQVMKLYFPSAYDVKHLMKHAIRLHNSGLLTPSDPSSADILQKFEHKSGLENIADSLKIKRVGNAHQAGSDSLLTGKVFFQMRDKIFNGEIPEEHVGKVWGLGIPELLVLERLPFGNNGGNQDSAQGQGPNGQHNGAPSTPNTASVGLVSTPAAQSHNTNGISMGPMTPGGGGGVFGNFAFGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRP3</accession>
    <name>A0A1B7XRP3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150947.1">
        <property type="nucleotide sequence ID" value="XM_018308629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRP3"/>
    <dbReference type="GeneID" id="28872736"/>
    <dbReference type="KEGG" id="chig:CH63R_13655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13655"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="341" mass="37802" checksum="3357E302FE83F5F2" modified="2016-11-02" version="1">MSLKRKRDMDEILKSRSVNFVVGPKRTMYTVHSASLTALSRPLKELIVPNRRRIGYETVVWLHVEPSTFINLMEYAYSRDYTIADLPKKKNSGKNSAECRESGSVKYETDSDDDKSSSEDEAYLPARPITTISAGKKPDTGTDEAEKADSLYSWILEVSKSPSSPQHWCAQYKFCLENFPIDTTVNSPTDAWLKGNQLQHDSGYQAVLKTHLNLYFLADEHEITELKDLCLERIRLTLLHAPGTSEVASSVLDAIHVVYANTDIGNPLRSLLVKYCATDMEWMMGGGGGGGVVQITPVIRGVPGFAADLLLEIPHAYWKEVGDGGAAGLERLRSSRLASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS56</accession>
    <name>A0A1B7XS56_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf1445 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-glutamate cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151098.1">
        <property type="nucleotide sequence ID" value="XM_018308780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS56"/>
    <dbReference type="GeneID" id="28872887"/>
    <dbReference type="KEGG" id="chig:CH63R_13806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13806"/>
    <dbReference type="OrthoDB" id="10262538at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047820">
        <property type="term" value="F:D-glutamate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2040.10:FF:000001">
        <property type="entry name" value="D-glutamate cyclase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1640.10">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2040.10">
        <property type="entry name" value="PSTPO5379-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009906">
        <property type="entry name" value="D-Glu_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32022:SF10">
        <property type="entry name" value="D-GLUTAMATE CYCLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07286">
        <property type="entry name" value="D-Glu_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="PSTPO5379-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32885" checksum="7B68BC9611D34587" modified="2016-11-02" version="1">MTVVYKTGEDARLAFRSGTFTSTTSGQAPTYLQANLIILPKRYADDFRLLCQRNPVPCPLLAESASPGDFQRLKSHITSHDGTASLPVAENIDLRRDFPRFRVYENSKHVPVNGESEPLSVEDQWLAGDHVGFLIGCSFSFERALAEAGLRPRHQLHGRSVAIYRTSIPLCAAGVFTGATYVVSMRPYRPSEIERVRDVTRPFVATHGEPIAWGWDGAERIGIRDVTKPDWGDVTLRLDGEGVFGPDDDEYVPVFWGCGVTPQEAVMRADLEGTVMGHAPGHMTVLDVREEEIFPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS57</accession>
    <name>A0A1B7XS57_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151072.1">
        <property type="nucleotide sequence ID" value="XM_018308754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS57"/>
    <dbReference type="GeneID" id="28872861"/>
    <dbReference type="KEGG" id="chig:CH63R_13780"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13780"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="44744" checksum="139BDBB7560CC21C" modified="2016-11-02" version="1">MLGILNTANAGMRSGVQGADQDCREEDTPPEVEGGLQNMQKQKGQVQPSCSRCERLHICCEYTHLRKPPSPPYEERCKFQDPSPKLEPATPCAPVAGSPGLDLMQLELLHTYINFTSLTFPWSSALRDFWKITVPSLALQHEYLTRAVLCIPALHLAHLRPERRGFYVSLALENHRLASESVRLLLENVSEKNGVPLFLFSALDIIIADGDASFQDLLVILQGMRGLLEMLWDTLAASALAPLLSYGSGRLITQQHSFHPAETDFHPTCNSLDDFQARINTQGMDPDTLMAYNRAIEALWGVIDWRRQHWEEADALIWVYRCLVDFIPLLSLQKQEALVLLAHFAVVLKTCETRWWMQGWAIRIISNAYQQLDDEHKIWVYRPAMDIGWVVPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSW4</accession>
    <name>A0A1B7XSW4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_14071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151363.1">
        <property type="nucleotide sequence ID" value="XM_018309045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSW4"/>
    <dbReference type="GeneID" id="28873152"/>
    <dbReference type="KEGG" id="chig:CH63R_14071"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14071"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="35589" checksum="29BD5A4E9CEA4D7B" modified="2016-11-02" version="1">MPFDTELTRRLGIKVPIVQGGMQHVGTADLASAVSNAGALGIITALIFPTPEELRKEIQRCKTLTTRPFAVNITLLPALVPPDYAAYAQVVIDEGIRIVETAGNSPGPVIKQLKAAGVIILHKCTTIRHAQSAVKLGVDFLSIDGFECAGHVGESDITNFILLSRARQSLKVPFIASGGFADGQGLAAALCLGACGINMGTRFMCTLEAPIHHKIKEEIVKAQETDTALLLRRWRNTTRLYKNKVTEEAIKVELESKSGEFSEIAPLVSGKRGKEVFITGDPDYGVWTAGQVIGLIHDIPSVKDLVPRIEKEAEAALRERLSLIKPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTW5</accession>
    <name>A0A1B7XTW5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151729.1">
        <property type="nucleotide sequence ID" value="XM_018307312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTW5"/>
    <dbReference type="GeneID" id="28871419"/>
    <dbReference type="KEGG" id="chig:CH63R_12338"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12338"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="482" mass="52026" checksum="2FC5D030AB1E41E3" modified="2016-11-02" version="1">MVALEAPEEFRSSHPTASTQGQLASDAPQLQGLAERHPELLMYTLSAEGYEDVRSFFSASMVQQPLAVIRPRTEAEVSAVVQEVRAQGIPFGIRSGGHDLTAAQAQGRDGVIVDMRGMDGVSVAEDRKSARVGGGILGIKLSRFLQQHGLLTPHGWCPTVSMAGWALGGGYGYSSAFYGLGVDQILGARVVLANGEAVDTDDHADLLWALRGAGNGNFGIVVELRVKLYPQTGFLAGFLGFPSEQAGDVLAGYGKFEKEEEDEVPVNFTGEVSHMTLPGVGPVIAWLFAWTSENEDLDGGWAFLDKMKGLGTPVLNTVAAVDDYTFFNTIPSPTNVHWRPRLRTFECFTPEVASVFGKHPPPAPTCGTVIHSAHGRALDENTGACYPLRTRHHIANPSAGVVDATAQAAEFGEYKRWADGLVDDLSRQGLTLPYGHRNLGPEEDMDWVATYGEETLARLKEVKGKFDPGNLFKTGYPRLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTW7</accession>
    <name>A0A1B7XTW7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151723.1">
        <property type="nucleotide sequence ID" value="XM_018307306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTW7"/>
    <dbReference type="GeneID" id="28871413"/>
    <dbReference type="KEGG" id="chig:CH63R_12332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12332"/>
    <dbReference type="OrthoDB" id="4387630at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601063" evidence="1">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="165" mass="16983" checksum="B060C6C402EFE379" modified="2016-11-02" version="1">MPSTLRNILIGLSALTASTYAEHLRVVWSSGSFGAIGGPSGGGTNGGYTGFAILNDAGEAVYDQAYPDDHSPCYNTGDGRTFTIEGDCWDNARVFHCKSDFGGAPETCEVKGHDGTVLGSGTQQKDTNFIGIAIGIDATCVVEFESDGPGCPVDDGNGPLHVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU22</accession>
    <name>A0A1B7XU22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151768.1">
        <property type="nucleotide sequence ID" value="XM_018307351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU22"/>
    <dbReference type="GeneID" id="28871458"/>
    <dbReference type="KEGG" id="chig:CH63R_12377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12377"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="186" mass="19837" checksum="6664B45A75BA7358" modified="2016-11-02" version="1">MLGWSHFGSLSHTHTHTHTLTVALPHASTHSLGVGAANGTTSPELLCQGTGPLRFGGPHLIPHRAHHGVVLFPVRRLQCSWGPPGVGGNGTRKMVDGPHEAVNNTFEYRTAQCQLESLEMPDVTTTVTSQQSRSASPNRTAPDHSTPYPHRPVPSLRLQPADAAADAAAAADLPVYNCYPCPPMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU32</accession>
    <name>A0A1B7XU32_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151795.1">
        <property type="nucleotide sequence ID" value="XM_018307378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU32"/>
    <dbReference type="GeneID" id="28871485"/>
    <dbReference type="KEGG" id="chig:CH63R_12404"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12404"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="167" mass="17778" checksum="B8264B9BCB1969B2" modified="2016-11-02" version="1">MPSPAPAPAPCDPSPDIGHISAIGCGLFRRLLIFGKDNCQEGAKITFPLPSLQSYLFLLKFPSRNPCLASCTSRTPTSAPSPPHLMGESTLSSPAPPHHSSGSAGVAKVQVVPSDRDPNLRERCLDDDDDGGGDNDDNDDEGPYPLWRNPSTTCRDRVMQGRGGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUB1</accession>
    <name>A0A1B7XUB1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylornithine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151879.1">
        <property type="nucleotide sequence ID" value="XM_018307462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUB1"/>
    <dbReference type="GeneID" id="28871569"/>
    <dbReference type="KEGG" id="chig:CH63R_12488"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12488"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601088" evidence="4">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="162" mass="18383" checksum="D42EB3ED4BC77174" modified="2016-11-02" version="1">MTYRFFFFLSILFASVCVADDAEIIDLHKSLVSIQSTTKTGDPQTDERNVQTFIENWLKETAEKNNFKINIERQQVTEGRDNLYVYTGTERSTSVMMTSHVDTVPPHFGYRVEGDKIYGRGANDAKGCVAAMMIAFRDLLINKQIKEEGDLSLLFVRLAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUP0</accession>
    <name>A0A1B7XUP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial s-adenosylmethionine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12614</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152005.1">
        <property type="nucleotide sequence ID" value="XM_018307588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUP0"/>
    <dbReference type="GeneID" id="28871695"/>
    <dbReference type="KEGG" id="chig:CH63R_12614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12614"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="101"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="307" mass="32631" checksum="0384537B5B801FC0" modified="2016-11-02" version="1">MSSSNPPFTTALLAGGIAGTTVDLSLFPLDTLKTRLQSSAGFFPSGGFTGIYRGIGSAVIGSAPGAAFFFCTYEGSKSLISARLASLSSSSSGTTKPAAWVDPVSHMLAASLGEIAACAVRVPTEVVKQRAQAGQHGGSSLLAFRSILAQYNTPAGLAGVWRELYRGWSITVLREVPFTIIQFPLWERLKRWGRERKQNKNWKLDVDGAAKKQIEYEVSAAESALYGSVAGAAAAGITTPLDVLKTRVMLSQQKEKIGDVLTTIYKQHGIRPFFAGIGPRVMWISIGGSIFLGSYQFASNTLTGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUZ4</accession>
    <name>A0A1B7XUZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152094.1">
        <property type="nucleotide sequence ID" value="XM_018307677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUZ4"/>
    <dbReference type="GeneID" id="28871784"/>
    <dbReference type="KEGG" id="chig:CH63R_12703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12703"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017745" evidence="1">
        <location>
            <begin position="16"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="572" mass="61360" checksum="520AB58C413162D3" modified="2016-11-02" version="1">MAWWIQIVPRPAVSAAVRLILRATPRLNLPLSSPSPAPSFASASASVAPFLRGEPGSLLLGGFGGIHRATLASPSTPRPEQLRSDTGPPLGFRWALSLCLLLTAQLFPSVTASSHLSSASTCLPLSASSLAESISLNQSSPLFSRSLDLNSSCPQTILAQTDKMGSLPGAIPPFRVFIVGTSYGGVSAALNLLDLSSGKPPRLAHTPYEHHPDFKNIPIDITIADERDGYFHIIGTPLAFADSKYAAKSWVKFDDIPSLQRPNVRFVQGSVSKVDPATKTATVLDHVTKQPRDYSYDFLIAASGLRRVFPVVPQSLTRKQFLLEAEEQIRSVKNAPDGVVVVGGGAVGIEMAAELKLSEPSTKVTLVHSRDKLLSSEDLPDECKDKALELTREAGVEVLMSHRVKETRELDTPAESGRARYEIEFTNGTKLVASQVIMAISRSVPSTDYFPAAAKDEQGFVKVHPNLVLSGDVPNARDHLAVGDIALWSGIKRCGSAMHMGHYAAINAHQLMLAKLTGQAHKPTFSELGHVEPMIGLAIGKKAVASGPLVGTTWGEDVMQAYFKDDLGFNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV85</accession>
    <name>A0A1B7XV85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152207.1">
        <property type="nucleotide sequence ID" value="XM_018307790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV85"/>
    <dbReference type="GeneID" id="28871897"/>
    <dbReference type="KEGG" id="chig:CH63R_12816"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12816"/>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="24833" checksum="D44CFDAD33D33271" modified="2016-11-02" version="1">MIISTDMLSDYYPSSRVGSNEPSCIRSRKAWMIDHTTYVSTREGGTCSFRSPNPKELHEMQWQIGIGRAGRFVKEEEVVPATPSTQEANMSTWNDNAEADKSQVNGPRERRSLSLLRIVKSRRDTLPAEGSPELQPDNKRRGWFANIFGFETVLSLREPPDLKPVPLPEGCTTPHSIFARKFSLIADNQPLPPSLSHEMMPTADIKARNLLADAAVQGLMGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVF9</accession>
    <name>A0A1B7XVF9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CC1-like family splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152287.1">
        <property type="nucleotide sequence ID" value="XM_018307870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVF9"/>
    <dbReference type="GeneID" id="28871977"/>
    <dbReference type="KEGG" id="chig:CH63R_12896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12896"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000876">
        <property type="entry name" value="RNA splicing factor (Pad-1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000354">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="468"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="565" mass="64257" checksum="969A2DFBF9D856EE" modified="2016-11-02" version="1">MSGLDVEALLDATAKSSTETKTHDVDERPNGDRPERKERDRGRDGSRDRDYERRRRDRERRDRSTTRSRRGTPDDVKASTPRSDAGSHKSRRRSRSRDDDRRHSRRHRGDGDYYRGGRARSRSRSPHRSYRSSRDDYRERRDRSDRYSGDHRRAKDDDRPETSSKREATPQLTEDERDRRTVFVQQLAARLRTRDLKAFFEKVGPVTEAQIVKDRISQRSKGVGYVEFKNEDSVTQALQLTGQKLLGIPIIVQMTEAEKNRQVRTTETTSAHPNSIPFHRLYVGNIHFNVTEQDLQAVFEPFGELEFVQLQKDDNGRSRGYGFVQYREASQAREALEKMNGFDLAGRPIRVGLGNDKFTPESTANILQRFPGQNPQFQGSAFSGAGGRGPQTSAFDRAGGRDSEKSGGASALDDTDVAGVNFNNYSRDALMRKLARTDDASNGVDERQVLKPKTETKPLPVNVNMASRCVVLHNMFDPEEEEGDEWVKELEDDVRQEAETKYGRVVHISVDPNSKGDIYLKFDKVQGGENAIRGLNGRYFGGRMIDASPVVDAVYSSLFSRTRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVJ9</accession>
    <name>A0A1B7XVJ9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152327.1">
        <property type="nucleotide sequence ID" value="XM_018307910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVJ9"/>
    <dbReference type="GeneID" id="28872017"/>
    <dbReference type="KEGG" id="chig:CH63R_12936"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12936"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="61"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="37185" checksum="2A118E6F0F89A56F" modified="2016-11-02" version="1">MDAESATDTARPTPPPPLPDEESHLRARISDARFWVEFSLFDDGLDAARAAALVPLTLPRFHRFPDLPPEIRLKIWSYLVVPRVVTACCFERDDRLPAQREAFARRSVPAPLGSSSSSPSCTPEEPATTTTTVFNPTCPAILLVCRESRALGLEHYELSFGWKISALLSDTPIARPPRAWFNFRLDALYLAGELEAYDQYGFNSPVVYFLRRCDAARVRHVACSFEALHYSEQGSDQVFGCLWHIVDRFSAARRLAVAITPRDEEGMKGCLVLGADDNIMHKIWNGWVLGTTVTSSSLADTQIFLVREADLADVMASHAAEEDEGKRGTRRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVZ1</accession>
    <name>A0A1B7XVZ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152436.1">
        <property type="nucleotide sequence ID" value="XM_018308019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVZ1"/>
    <dbReference type="GeneID" id="28872126"/>
    <dbReference type="KEGG" id="chig:CH63R_13045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13045"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="185" mass="20747" checksum="6E35E0710E23C805" modified="2016-11-02" version="1">MLAFPNANEGFPKFSAATSHQVTAEERVTAIDFVNRHNFLFEEFDTKKLLTTQLPEMTLYHMYGHFKGAEAVKDFIESKYPPLIPGVTRHATNHIVDRDNETGGVVVRYHMTLVRQAWPEEAGKVTTKDAFEATGLPGIWIYSAVVDRLKMTDDGWKLYSRINGSTVVNKSLNPGASEASKKNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYB5</accession>
    <name>A0A1B7XYB5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153257.1">
        <property type="nucleotide sequence ID" value="XM_018306416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYB5"/>
    <dbReference type="GeneID" id="28870523"/>
    <dbReference type="KEGG" id="chig:CH63R_11442"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11442"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF19">
        <property type="entry name" value="D-GULOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="96" mass="10218" checksum="801B274EE9F43438" modified="2016-11-02" version="1">MGGESSFNRAVVYTEPGTTKTEVVELPIPKPGPGEVLVRLQYSGVCHTDYGFCMNAFSSVPFPTPTGMSLRSQDCRRVGRILTAGITGQVGGHEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYG9</accession>
    <name>A0A1B7XYG9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetratricopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153323.1">
        <property type="nucleotide sequence ID" value="XM_018306482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYG9"/>
    <dbReference type="GeneID" id="28870589"/>
    <dbReference type="KEGG" id="chig:CH63R_11508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11508"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000005">
        <property type="entry name" value="Hsc70 cochaperone (SGT), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000207">
        <property type="entry name" value="Small glutamine-rich tetratricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000011">
        <property type="entry name" value="TPR Domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="6">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="37764" checksum="A4C5B1D54431F032" modified="2016-11-02" version="1">MATVTTKQRLAVAICEFLSTSVNDGTVPADDKDSIDVAIQCIADSFKVDPTDKKLLADSVGSQNLHQIYSVYEKLKKASTPAAAAGASAGAAAAGAADAAATASSKVPTEQEKKDADALKSRGNAAMASKDYPSAIALYTQALALNPGNAVFLSNRAAAHSAAKDHESAKADAEAAVTIDPAYTKAWSRLGLARFALGDAKGAMEAYGKGIEYEGSGGSEAMKKGFETAKRRVEEMQAEEVDLPRQSPGVGGGGAGGAGAGMPDLSSLASMLGGGGAGGAGGMPDFSQIMNNPMFASMAQNLMSNPDMMSNLMSNPRLREMADRFGGGGGMPDLNSLMSDPNIADMARNMMGGAGGAPGGAPGGAPGGGAGAGRGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZA9</accession>
    <name>A0A1B7XZA9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_11793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153608.1">
        <property type="nucleotide sequence ID" value="XM_018306767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZA9"/>
    <dbReference type="GeneID" id="28870874"/>
    <dbReference type="KEGG" id="chig:CH63R_11793"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11793"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="53"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="573"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="608" mass="67272" checksum="317AAEEB6B089659" modified="2016-11-02" version="1">MAYYQDYQTPYDYAAFSTPFPGNLYQNEYSMELYRQQAAMMNRGMFPGVGGKVTESKPRLAKDEVDKLEREFQRNNKPNSSLKKQLAEEMRVDIARINNWFQNRRAKAKQEKRAQENEARRKSEQAADESTNSETIKESFYDHDDDLRPSTAPFPPVKAHPGVTSSRESSPSEGTETPEQSAEQPHAIAEETESEYASPESSNSFQHQDLNISYALASDAFFSDQPSCDFTSSMPLEASHPTPGHLTLSIPNQFMSHLPESTSASSFSSYHHLSSASDFGDSLAPMAHSLSGNLTEPIPINIKQEQMQAEALNRFDQFSPASMSQSPPEMSTSDLRFRSPSTIDIASRRNSKRPAQLVSCMRSQSYNYSGPKTGIEMPRRMEAPSPMRRVASATGNFPRGIQKMASSGPRSPLYFDRNQENLLLQMASRSPVSRSPAAPPTPNTPIVPSQQALRETTVSSMSSADDEKSYSHQNTLTVPQYAMDPTMRTPPDTPGMLTMPNSMFPTFDFNVPDDPLPTPSFGGFEQDFPALSTSIPSYVAHGCASQPVTPSYPPGNMGPAFYSSYGGGGNTEYNWSDASAVSAKPSPDQSRSRQFQFTNMTAQDFHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y009</accession>
    <name>A0A1B7Y009_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153849.1">
        <property type="nucleotide sequence ID" value="XM_018307008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y009"/>
    <dbReference type="GeneID" id="28871115"/>
    <dbReference type="KEGG" id="chig:CH63R_12034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12034"/>
    <dbReference type="OrthoDB" id="4813489at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="490" mass="54078" checksum="3D5187A157083967" modified="2016-11-02" version="1">MEPSKAKYDNEVHETTDNAAGTSYVYDGGLVDEVDEAYLRAPKSTRFYRGVLFQMILFGALSFVGPAMSDAISNLGGGGLSTPYLANMATALSYMAGCMITVFGGPLINKFGIKWSCMIAAVSMPLAGSAYYVSAKYHVDWYLLFARLLGGFTSGFLYVAETAAMLSYPEPNDRGFYLGIWSAMRNSGSVIGGAINFSNNYSRANAGGIAWSTYLIFIGFECTGVIWAIILSPTRRVRRRNGSKIPMPSNISWKKELIALWRHLQRRKTWLVSIPAFYSFFFGGTMGTYLSLHFSVRARALSSLITPSLTIVMVIAYGKLLDTSRWSQAKRAWISFVFWVIPQAACFIWIGIEYSKFGGGKTEEALDYALHTRRWAEAYLPYLVMFSTGYWTQLSLYWILGTFSTDVGSSSRSGGLFRAFETAGQAVSYALNSKTGADPRIPFYINAAILVVTIPCMVFLIRLVPEVPATTDIDAADVVADEDASDPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y064</accession>
    <name>A0A1B7Y064_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase family M20/M25/M40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153925.1">
        <property type="nucleotide sequence ID" value="XM_018307084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y064"/>
    <dbReference type="GeneID" id="28871191"/>
    <dbReference type="KEGG" id="chig:CH63R_12110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12110"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02697">
        <property type="entry name" value="M20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="44852" checksum="9FCF13751D879021" modified="2016-11-02" version="1">MTSSAPPTDYQRLDAWIDAHFDEEVSFLQALVRVPTDTPPGNNAPHAERTAELLREFGFEAERHPVPAVEVRAYGMESITNLIVRRRYGSGAGRTVALNAHGDVVPPGEGWTRDPYAAEVEDGVLYGRAAAVSKSDFATFTFAVRALEALGAPLRGAVELHFTYDEEFGGELGPGWLLRQGLTKPDLLIAAGFSYEVVTAHNGCLQMEVTVRGNQAHAAIPDTGVDALQGAVAVLNALYALNAGYRRVRSGVEGITHPYLNVGRIEGGTNTNVVPGKVAFKLDRRMIPEEDPAEVEAEIRRTISDAAASVPGIAVDVRRLLLANSMRPLPGNKPLVEAIQTHGGEVFGRPIPAMGTPLYTDVRLYAEAGVPGVVYGAGPRTVLESHAKRADERLQLEDLRGATKVIARSLRDLLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0M0</accession>
    <name>A0A1B7Y0M0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154080.1">
        <property type="nucleotide sequence ID" value="XM_018307239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0M0"/>
    <dbReference type="GeneID" id="28871346"/>
    <dbReference type="KEGG" id="chig:CH63R_12265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12265"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="36215" checksum="92AD6E3D96344B22" modified="2016-11-02" version="1">MPIILAPLAVFALPPDDYMSPLAERQSPTSIDRLFKARGKLYIGVSTDNGTLQQGKTAAIIRNNFGQVTPEYSMKWDALEPARNRFTFGNADFLVNWARQNGAKTIHGHTLLWHRALPAWVSVIRDKATLAVVVETHIKAVVGRYKGKVRSWDVVNEAFNDDGSLRSSVFSRVLGEAYIGIAFRAARAADPDAKLYINDYNLDRADWAKVVAIVSKVNQWLGQGIPIDGIGSQTHLAQNMAGNVLGALQKLASARVTEIAITELDITGAPPNEYANVVSACLSVPKCRGITVWGVSDKNSWISTATPLLFDVNYEPKPAYNAIVTRLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y150</accession>
    <name>A0A1B7Y150_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154255.1">
        <property type="nucleotide sequence ID" value="XM_018304831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y150"/>
    <dbReference type="GeneID" id="28868938"/>
    <dbReference type="KEGG" id="chig:CH63R_09857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09857"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="70"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="545"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="605" mass="66430" checksum="20CDA0F2C274024F" modified="2016-11-02" version="1">MHSPTDSSTSSRSDDSPIVISPAASPTASPPEKAPLTTSSTTTTTTTTNKTPTATTTKRPSSPPPKVSNTDVLIIGAGPTGLTLALELSVQSIPFRIIDKLPEPSDKSRALAVQCRSQELLNRHPHIAESMLADGTKGPGVNIYCNKRHLVTGTFDDLGFDDTRFPLPLWVSQADTEAAMLRQLEVYGGTVERGVSAEDIKQDGVRASATLVRSSSSSSSSSTPEKEILRAKYIVGCDGAHSVVRHSADVTFEGSQYPQQYILCDAKVRGDYDAERVSLFLGSRVMVVFPLRDGVIRMVGERSSRSKREGDPDVAEIEAFMEEVMGRRPEIEEALWLASFRWNCRGVNRYRDGRLFLAGDAAHIHSPAGGQGMNTGIQDAVNLGWKLAAVIRGEKEESFLDTYHEERHPVGQHLLTGTDRMFSMVASQNTIFTTVRNALMPWIVPRVWNNRARRLSVYTFISQMAIKYRRSSIVGTAIGFEGPVRGGWRAPDGQLTDERGEKARWLLGMTSARDHTILLFAGVEADEENLEAAEEKLVTDGRFKEYEVVKVYAGDTVGKGGYKDVDGMLHKRYGFEKGAGFVVVRPDGYVEFIGPAECVEEFLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2A2</accession>
    <name>A0A1B7Y2A2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_10265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154663.1">
        <property type="nucleotide sequence ID" value="XM_018305239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2A2"/>
    <dbReference type="GeneID" id="28869346"/>
    <dbReference type="KEGG" id="chig:CH63R_10265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10265"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="905"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="794"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="935"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR06145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="958" mass="105349" checksum="8900A93C9D3A34CE" modified="2016-11-02" version="1">MMQAPGSSQRMQRRSPGAEPGPPPNVPVRSISPASGMQPRASNASNRSAPPSGGMRRSNATDGQVSDVYVRLGYEFNMACRAFTAINVDTSDLGNVPELLRSILEATLSQEASTESLEKYLPRIRDIIINLLHGLKRKQQKLRQKQPRDRESGGSAGAPERTTSTSTIGSANTGLTNLLEEGIQNGYRPDAQRESSQSAGGPASTSPNRRYMAPRDQSRGSVNSEQSSLSSNTMQNISVVPPYPGDEASMPSAPSAEVNVDSFPPPPPPPKQQSSAFAALQKGGDLERRASRRYSQYQISKHLGSAMNGVPMLPSQNSPIPNRGRGEVRESLRAVQTRETVRQSRVPKQPQLDTSPVRAQSRNNEEPPAELPAARPESPTIQTPEDKYPQPSATLKGPLSDDLPIMSPDDDRKPESPNKDEQKESPVIRTPEKKRDASFLHEQSPPLTTDLTLFLQYKSKVKKFVLPEGYSELSIGRLQLAFIEKFSWNTHANGADLPEIYIQDPVSGVRHELEDLSDIKDRTVLVLNVEPLDEVKRHIDEGIGQLKKIVQDVKQNMDDQSLAIQRVSERQQEAATEMARLASAPPAVSAPADGTKSVGVAGGRKLAAGHITEIQTLRRDLAVMRQAYSNFQSEIQGSMSAIRAKASNVKAAVVKTSIPTIEGDTGHAYVTKGREQLNTDSDRLVARVDDLQDLVEDLRKDVVHRGVRPLPRQLETVAMDITKLSKELKKVEDYMKEEKPIWTKIWEKELEDVCKGRDELRLMEDLMIDLQDDLEKASETFALVEQATKEQLKDNGTTASAGTARNFSKGLNSLGNSSDPNAAKDGVLGEVRALQPNHENRLEAIERAEKLRQKELEGRKGNELQRELSNFVEEGKLKKSGGFEEVERARKAKDDMIRRQVWERQNGVVAEEEEEEVEYEEVEEEEEEEEGGATGEANSADAPADADKAAASAAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2V7</accession>
    <name>A0A1B7Y2V7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154857.1">
        <property type="nucleotide sequence ID" value="XM_018305433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2V7"/>
    <dbReference type="GeneID" id="28869540"/>
    <dbReference type="KEGG" id="chig:CH63R_10459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10459"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="82"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="55475" checksum="C95CA8B771FB3171" modified="2016-11-02" version="1">MSSLETSNPPLTLLRVSGTKIVDENGTEVLLKGAGIGGMLNMENFITGYAGHEHEHRAALAEVLGQEKADFFFSRLIHHYFTDADAALYASLGLNCLRVPFNYRHFMDDDNPSVIKDAGFALLDRIVDICARHNIYVILDLHAVPGGQNQDWHSDSGISRALFWEFRDFQDRAIQLWEALARHYAGNKVIAGYNPLNEPADPVHTRLIAWYERAEKAIRAIDPDHILFLDGNTYAMDFSAFSPDKTLPNSVYSCHDYSLMGFPLPEQYEGTEEQKQKLRQSLLRKVEFMQKAGVPIWNGEWGPVYQDPRTDPDAAATNEKRFALLKEQLAIYREFGGISWSIWLYKDIGYQGMVYVDPESPYMRLIRPFVEKKQRNGLDFWGCVDKSAVDGAAYAPFIARLKEQVPEHLQKKKYPKTWTFDRQVERVVRECLMSEYAGWEFAELFRGKTEEELEALAASFALENCRTRDQLNEYLREDAVKGNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y424</accession>
    <name>A0A1B7Y424_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155233.1">
        <property type="nucleotide sequence ID" value="XM_018305809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y424"/>
    <dbReference type="GeneID" id="28869916"/>
    <dbReference type="KEGG" id="chig:CH63R_10835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10835"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="196" mass="21413" checksum="DDEDC6BF6136D478" modified="2016-11-02" version="1">MCGGSNRCNCTATYTRQKLLSNVVLADKKYTTCLVSSLSVPPKRATSCAAGAMQQCLFPVKPESLYLHVSNCLPLAHSLVLGLVSCHNHKQFVVVAALSIASHLRSRKQPWPSVVDVVRQPRTMCHVYASVAAVRHHPAWHQKSPSNNRPRPASRSSEDEPCTGSEATNKHNPSVPAAFLQHRPIYDLMLHSACGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4T5</accession>
    <name>A0A1B7Y4T5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155533.1">
        <property type="nucleotide sequence ID" value="XM_018303510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4T5"/>
    <dbReference type="GeneID" id="28867617"/>
    <dbReference type="KEGG" id="chig:CH63R_08536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08536"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="230" mass="24826" checksum="D8846BB877B303D1" modified="2016-11-02" version="1">MSAIPRPVAGSKKVGLTMNTYAILWRDSTLYCLRPAFDLIRAGLCRPLEAFRCRGYQSQREIAMEACAGLRCTRTQRSVSLLVDRDQSSSVFLVYPGSAVLAPPPPGIDSKQSRPQCCSPSEEAAAAANNAAQSQESEVMECSSVGVCFSQSAKQQLAILCPISKALLPIRILIRAAAPEHDHIAASFGADITASLDQSIPIESRTNKTPSPTRPKDVNLITNIHDDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4V4</accession>
    <name>A0A1B7Y4V4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155597.1">
        <property type="nucleotide sequence ID" value="XM_018303574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4V4"/>
    <dbReference type="GeneID" id="28867681"/>
    <dbReference type="KEGG" id="chig:CH63R_08600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08600"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="269" mass="29085" checksum="BB36429D673150DD" modified="2016-11-02" version="1">MVPPRSGSAMGMRSRGPVELNVNLAKSYEIRGPKSPMPRSPLRDVTHEDRGGRGGSYEDRLEGAIHVLRTEANALMALTQLYASERVCRDGFHRAVEALVRHRDHRGKVVFIGVGKSGWIAKKLTATFSSLGLPAVFLHPTEALHGDLGIVGEHDTLIMITFSGRTPELLLLLPHLSRKCPLVLLTSPTCMETCEIARQRPDLILLPAPIPESEKETFGVSAPTTSTTMAIAVGDALAYVASKEMYPSVSSVFAKNHPGGAIGQAFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5J3</accession>
    <name>A0A1B7Y5J3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_08785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155782.1">
        <property type="nucleotide sequence ID" value="XM_018303759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5J3"/>
    <dbReference type="GeneID" id="28867866"/>
    <dbReference type="KEGG" id="chig:CH63R_08785"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08785"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601359" description="Beta-xylanase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="9">
        <location>
            <begin position="52"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="375" mass="40958" checksum="22204F939A33B7F0" modified="2016-11-02" version="1">MKFSLALAAAPLAALATPLGVAPAAHSPHSSRSSHSHSVSHRHPIPARLAERQASDSIDALIKKRGKLYFGASGDNGIMQQGRTEAILQANFGQVTPEYSMKWDATEPAPGNFTWGNADYLVDWAQTNDKSVHGHTLLWHTALPTWVSDISDKKVLTKVIERHVHTVVGRYKGKIRSWDVVNEIFNDSGTLRNNTFFNVLGESYVGIAFRAARAADPAAKLYINDYNLDNKDWGKLPALVNKVDQWIGQGIPIDGIGASNLCFPGRVCSQSHLVPNMSSNVEAALHALAASRVSEILITELDIDTAPPAEYATVVGACLNVPKCRGITVWGVSDRQSWKSEKKPLLFDENYNPKPAYDAIVKKLKGVVNGWVYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5V8</accession>
    <name>A0A1B7Y5V8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_08918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155915.1">
        <property type="nucleotide sequence ID" value="XM_018303892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867999"/>
    <dbReference type="KEGG" id="chig:CH63R_08918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08918"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="399"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1683"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1806"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1475"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1648"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1763"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1883"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1654"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1766"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1900"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2198" mass="239309" checksum="078A896B2B2E6276" modified="2016-11-02" version="1">MEHREPQHLGNLCRQSFKMADMMSYLLFGDQSLDTHGFLAEFYRSGNPSTLAKTFLDQAGQALREEIDGLGKLERSKLPTFLSLRQLNERYHAQGIKHPGVDSALLCITQLAHYIDRAEKEPQDAAPHDHTFFMGLCTGLFAAAAIASTPSVSTLIPIAVQVVLMAFRTGSHVGSLAERLSPPVGQSEPWTHILPGLKESDAKEALTNFHESNYIPIASQAYVSAVSASSLAISGPPATLRALEDQNVFGVKPTAIPVYGPYHASHLHGTADIEKILRLNDPKVVEALAKSKPRSAIMSGTKGIWFAETDTKSLIKAVAHECLVDVLQFQKGIEGCIETARDFEGSTCLVIPYGPTHNAETLSKMIKDRTQLDVQVRLGPRIQRESINSPIGNHGSSGKCKLAIVGMAGRFPDAASHEKLWELLSKGLDVHRVVPADRFPVATHYDITGKAVNTSHSQYGCWIENPGYFDPRFFNMSPREAFQTDPMQRMALTTAYEALEMCGYVPNRTPSTRLDRIGTFYGQTSDDWREINAAQEVDTYYITGGVRAFGPGRINYHFGFSGPSLNIDTACSSSAAALNVACNSLWVKDCDTAIVGGLSCMTNPDIFAGLSRGQFLSKTGPCATFDNGADGYCRADGCASVIVKRLDDAIADKDNVLAVILGTATNHSADAISITHPHGPTQSILSRHILDEAGVDPLDVDYVEMHGTGTQAGDGTEMVSVTNVFAPADRKRPADRPLYLGAVKSNVGHGEAASGVTALTKVLMMMQKNAIPPHVGIKKEINKTFPKDLSERNVNIAFHLTPFKRRDGKPRRIFVNNFSAAGGNTGLLLEDAPHLKASEADPRSHQVITVTGKSKAAMIRNAERLVGWMEQNPQTPLAHLAYTTTARRIQHYWRMNVAASDLPEAQRLIKDRLKENFTPISTQQPKVAFMFTGQGSHYAGLGKDLYAHYRVFRDSIDEFNQLAQIHGFPSFLPLIDGSEPDVTKLSPVVVQLGLCCFEMALARLWASWGIRPSAVMGHSLGEYAALNAAGVLSASDTIYLVGARAQLLVQKCTAGTHAMLAVTGPVEAIMEALGAQAEAVNVACINGPRETVLSGAAAKISDISSHLGTAGFKCTQLKVPFAFHSAQVDPILDDFETLARSVSFERPQVPIISPLLGKMVETEPINAAYLRNHARDAVNFLGGLVHAQQSGSVDEKTVWLEVGPHPVLANFVKSSFGISSVAVPTLRRNESTYKVLSNTLCALHTAGINLDWDEFHRDFTECTRLLDLPTYSFDEKNYWLQYTGDWCLTKNRGPSAVKAPLQIEPARPKLSTTSIHAVTNEDVNGDIAIIETETNLSRPDTRPLVEGHLCNGAPLCPSTLYADMAMTVADYAYKMLRPDAEPVGLNVANVEVPKTLIFDEKLDAHVLRTTVTANVALGYADVSFHTGEGSKKTEHAHCKVVYGSTEQWADEFERVSYLIKGRIDALEEAERQGKASKIGRGLTYKLFTALVDYDTKYQGMEEVILDSKTCEATAKISFQTTDKDGSFFFNPYWIDSCCHLSGFVINGTDAIDSREQVFISHGWGSMRFTEKLDASKTYRSYVRMQPVKGTKMMAGDAYVFDGDRIIGVAGDVKFQSIPRKVLNMVLPPRGRAAAGAVTASAAAPKAAAPAKAAPAKEKSGKEKASKQVTAGNLKAVNAKLAKRSVVQDVFDILAKEVGVTQDELADNIAFTDLGCDSLMALTVSGRMREELDIDIDSHAFVEYPTIGAFKAFLAQFETSDRKDSYVQDSGDSSGSVSETPELESDSNVTTPYEESDRSVKGDGDEEASGDLQNILRDTIASEMGVEVDEIVAAPDLAALGMDSLMSLSILGTLREKSGMDIPNDLFVTNPSLLEVEKALGISTKPKSAPAAPKPSKAPAPRREKVEPTREINTHPGNTTASITKPPPPREIIDNYPHRKATSILLQGSTRTATKNLWMVPDGSGCATSYTEISQVSSQWAVWGLFSPFMKTPEEYKCGVYGMASKFIEAMKARQPKGPYSLAGWSAGGVIAYEIVNQLTKAGESVENLIVIDAPCPITIEPLPKSLHAWFASIGLLGEGDDDNKKIPSWLLPHFAASVTALSNYTAEPIPKDKCPNVMAIWCEDGVCHLPSDPRPDPYPTGHALFLLDNRTDFGPNRWDEYLDINKFRTRHMPGNHFSMMHGDYAKQLGQFIREAVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Q2</accession>
    <name>A0A1B7Y6Q2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156209.1">
        <property type="nucleotide sequence ID" value="XM_018304186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Q2"/>
    <dbReference type="GeneID" id="28868293"/>
    <dbReference type="KEGG" id="chig:CH63R_09212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09212"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="139" mass="15135" checksum="65DD25C4D9E15513" modified="2016-11-02" version="1">MASPAKDRITCHVLDTSKGRPAKGIRVYLSTTTATASGPGTLREFESLTDDDGRVHTWLPFSPATASGEVPVYTLEDVLGAAPGPSSRWTLRFDTAAYFGGDDETFFPEAVVVFTVREGQHYHVPLLLSPYSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7U5</accession>
    <name>A0A1B7Y7U5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156516.1">
        <property type="nucleotide sequence ID" value="XM_018304493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7U5"/>
    <dbReference type="GeneID" id="28868600"/>
    <dbReference type="KEGG" id="chig:CH63R_09519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09519"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="516" mass="56312" checksum="93B2F6CC80FFE09B" modified="2016-11-02" version="1">MATGNSKSSPPPVPRDDQSNAPVYEEKPGVALEHTDQASDEEKHPQHLPSVTAPIEALGLEDWRGLEKKLVRRLDMTLMPMLWVLYLFNYLDRASISQARLSSFEADLGLTDTQFATAVAVLVPGYVAAQIPSNMILPYVRPSLYLPCCALVWSGVSAATAGVKSYNGLVACRVMLGLCEAPLLPGAIYIMSCWYTRKEIALRTAVLYTGLVLAMASSGLIAAGVYSGLEGVRGMAGWQWLFIVLALAGSCCAIVALVLLPDYPHSKTGSARWAMTEDMRRLAVARIQADRVSLPEAKSNSIWYGLKLTCMDYKTWIFVAINISISAAYGFLNFFPSIVRGFGFESRTTTLLLTAPPYVFAAVASLCNARSSDHFKERGYHMIGPVAIAIVGYIVCTATGNVPARYAASFLYIGGMFAANPLINTWLVGTLGRTPEKRATAIPVINVLGQIGNVIAPYFFPDRDEPRYLMAFLLMMGFAALGIACCFLLKFILIRSNKKLWAKAQEDGTVYNPYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7Z2</accession>
    <name>A0A1B7Y7Z2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156635.1">
        <property type="nucleotide sequence ID" value="XM_018304612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7Z2"/>
    <dbReference type="GeneID" id="28868719"/>
    <dbReference type="KEGG" id="chig:CH63R_09638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09638"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="204" mass="21597" checksum="4BDB015420B65629" modified="2016-11-02" version="1">MVVVLKEDEKILFEQFGEILSKNSNMKVSAYNYGDGPTTFVASKGEEAKLSGGYTNYSDDDTSAKIGYVRVGMDMDGSDPDAVFKTVEASTRASVYHVANNNGSQITQQSADILSAKVSTGVSGISGGNDGFPVYAGAEAKLNFLELKGSVFDAEVGLSAQTDLRFKDYSMGGHVLGIGCTVGKRVSVSTPFGSVEMDFSRGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y822</accession>
    <name>A0A1B7Y822_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156707.1">
        <property type="nucleotide sequence ID" value="XM_018301929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y822"/>
    <dbReference type="GeneID" id="28866036"/>
    <dbReference type="KEGG" id="chig:CH63R_06954"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06954"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="483"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="598" mass="65914" checksum="2FF3B3F9A1DDAED1" modified="2016-11-02" version="1">MRRAAARAVSRRVPLPRPTSTSAIALRCISTTPRMAQAPANPFSSGSPPSDAFQLLPESKKAGAAEDELYEAQIKEVEAWWQSPRYHGIKRPYSAADVVSKRGSQHQSYPSSVMARKLFNLVKEREAEGKPIHTMGAIDPVQMTQQAPHQEVLYISGWACSSLLTSTNEVSPDFGDYPYNTVPNQVQRLAKAQSMHDRKQWDARRKLKPEERIETPYVDYLRPIIADGDTGHGGLSAVLKLAKLFAENGAAAVHFEDQLHGGKKCGHLAGKVLVPIGEHINRLNAARFQWDVMGCENLVIARTDSESGKLISSAIDVRDHEFILGVADPAIEPLAETIQAMEAKGAAGAEIDTFEADWVKNTRLVTFDEAAIGHMQKEGVSQDKIDAYLERVRSDRDLGISQRRKLANEHTSTPVYFSWDVPRTREGFYHYRAGMDAATKRAIAFGPYADLLWVETGDPNVEVASTLARSVRGVYPGKGLVYNLSPSFNWMAHGFTDETLKSFIWDIAKEGFVLQLISLAGLHSNATITNELARDFKKDGMLAYVNTVQRREKEGGCDVLTHQKWSGAGYIDGILGAIQSGSSSSKSMGEGNTESQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8H5</accession>
    <name>A0A1B7Y8H5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156743.1">
        <property type="nucleotide sequence ID" value="XM_018301965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8H5"/>
    <dbReference type="GeneID" id="28866072"/>
    <dbReference type="KEGG" id="chig:CH63R_06990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06990"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="131" mass="14857" checksum="643ADF64F903DDDF" modified="2016-11-02" version="1">MPTKSASTQNHHLECPPRPTPTVRCTSDTGGLPKQCGLSMFCRRMYRRPVAQSWSGLRFSPTSPWAGFVAEITLTTPGERRHNQNALTDITAHRIHRRLPAYACSWFLLLGSLDTFVLRRPGTRYHRPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8H8</accession>
    <name>A0A1B7Y8H8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_07055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156808.1">
        <property type="nucleotide sequence ID" value="XM_018302030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8H8"/>
    <dbReference type="GeneID" id="28866137"/>
    <dbReference type="KEGG" id="chig:CH63R_07055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07055"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="251" mass="26030" checksum="FB65AB633EA1BE36" modified="2016-11-02" version="1">MRASTALAATVAMSANAAAATEIAAHPWLAPDASAVRSPCPMLNSLANHGYLARDGRAISMADLISGLGSALHFNESLVRTLGTPAFATSTTGDPTTFNLDDIAKHNVIEHDGSLSRADFAVTGDAKTFNQTVWAETRGYLEAGAAASAAAKVDTQTMAAARSKRIATAQATNPSFGLTSSQVTVSLGESAVILGTIGQSFSEPAAPVEWLRVVFEQERLPFAEGWTTSETEITTAQVLSLSQRIATSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8R2</accession>
    <name>A0A1B7Y8R2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156875.1">
        <property type="nucleotide sequence ID" value="XM_018302097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8R2"/>
    <dbReference type="GeneID" id="28866204"/>
    <dbReference type="KEGG" id="chig:CH63R_07122"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07122"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="71"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="62972" checksum="4F5D7ED1DDB8C172" modified="2016-11-02" version="1">MSKEDAQVGVVPPTYDSEKGAHNSVGNIHETDNREDDFRTRNGLNLRSFQRRDETTVGGEAELDRSMKPRHLQMIAIGGSIGAGFFVGSGSALTKGGPGSLLICFLIAGVMIFNVVYALGELAVLYPVSGGFYTYSIRFLDPSWGFAMGWNYVFQWVIVLPLELTVCSFTVQYWNKEISVAVWITVFWLFIIIINVFGTLGFAEEEFVSSAFKLIATVIFMVVGLVLICGGGPEGGKYDEYWGDRLWRDPGAFQNGFRGFCSVFVTAAFAFSGTELVGLAAAESTNPAKALPGAIKQVFWRITLFYILGLTFVGLLVSSTDDRLLSADNPYSEGVSPFVLAPLDAHLWGYDSFMNVVILVSVVSIGVSCVYGGSRTLTALAQQGYAPKIFTYIDRSGRPLPSVVLNLAFGGLAYVRMVSSGGVIFDWLLSLSGLAALFTWGSICAAHIRFRSAWKAQGHTLDEIPFQAIGGVAGSWLGLILVFVSLIAQLFVAICPPGKDGFASAEDFFKAYAALPVVLFFWACGYLWKRKGFLKLSQIDLDTGRREVDWLVIHAHRARVAAWPVWRRWLNTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8R7</accession>
    <name>A0A1B7Y8R7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mucin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156954.1">
        <property type="nucleotide sequence ID" value="XM_018302176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8R7"/>
    <dbReference type="GeneID" id="28866283"/>
    <dbReference type="KEGG" id="chig:CH63R_07201"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07201"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="533" mass="57147" checksum="BA9B60FFC9E1C67A" modified="2016-11-02" version="1">MSKAQSTQPGHQPSRSAGADLTLNLSSNNPFRNRAASPLLSGATYSNTTSPASPFDDPPPRPVSRNPFLDPSFSSSQPNLIGVGNMAPPFDTKASPTAEELFDGLTINDQKQSRPDGGRPSTNRPPGQPGRENIPPGRRGPPPPGHRPSRSQEEAMRQRRMQGGSNGGPPRPAGAPASPQRRPQERRPRRNSDSSVLIDIEKPLTEEEKKAKDARRRERERRAREGKDKDPKDKDPKKPSRRLDIIDQLDATSIYGTGLFHHDGPFDAANPHRNRKGSRRAPMHAFAKDSLNMSLGGSGPLNKRPDHATFLGNNDGDASADFATAAARNAERKADPAVFDPRARGSIIYGEESMGLGASTFLEGTPAARAAIQRTQAEQAQQAASEGLGRSKSIAQRIRGIKREPREYGPSGRITNPEGAYTSRRSPDGNGPSSSISYTGERNPFFSEYGKEPETISVRRNGARSPGSPPPVPRRGSANGLERRATADATSPTDDGPSKPSGGFLARVKSLKGGRRRQVSDAMAPPPAPGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB38</accession>
    <name>A0A1B7YB38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomere silencing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157830.1">
        <property type="nucleotide sequence ID" value="XM_018303052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB38"/>
    <dbReference type="GeneID" id="28867159"/>
    <dbReference type="KEGG" id="chig:CH63R_08078"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08078"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="729"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="917" mass="101863" checksum="20A5F7E5C3950A23" modified="2016-11-02" version="1">MMTSSRPRADVGGSFASRRGHASQLSISDPSHHVTETIGTLYGDEEDYSNDQRPLSFFGSSYSDQSTKQGEADPSAEDPHRQTLRSASDKTGPGATQNGTPALKKPQSLPARSPSQRSNSYENGPKSPPISLRDVKNESSQFPLGSIENPNDIAQELSNLQALRRMSMDVGNNADPDMLPFSGLSLVAMPPIAPTGDDDENDPSRLLWVPAAVHPELAPTEFKNFLEDRVKTIRRRSGDSSDGGMDRSDSGGGLRRKKSMLSRQIDNSGGRGAVGYVDGAERLGRKSSLREYSTPELNLNELVKDPTKVVRELSQESQAEGGVEDMPILPVAPGMGLRRSTRTTYRKNGSVRSGDRLPFSKRVASRHGHTDSSDSADTVPPLPSDVPEVPPLPSHQRVQSEPVAENFSRPNRSVRRQHKFSQDLDTASDGASSEVEEPVSPLSTRPEQQHPARTSSVAVDAKQSVQSNESPTTEDNGQRQQFPQRSSSQHATQPIPPQSPVEELPARSSKRPGAGSSAPSPTTPTAPQQPQVQQAKQQTNPHIQTSNDMASHPSTLPSSGASRTDTLTFIPTFPAEEKKTEEKRVGGKLRKERDDDASSISSTKSSGGWSKWLKGGGDDKDKKKKEDEKKKKHGAEKAQDNARLDVLQNSIEGVSSKGRESIIVDRDNVDNKLTEERKKETKKTDSKKEKEGGLFSGLFGGGKKKSEKESSSKKNQHLRVSEEVPYRPLKPDVDYHWTRFPLLEERAIYRMAHIKLANPRRSLLSQVLLSNFMYNYLAIVQAMHPQMQVPQSPQQRRLEEERRRKEQEEQYLAQQQQQQQQQQQQEATDQDSTGQYNFEYHRGETQYGDHPHDEVDYVDDAQIYEYDHGGDIDNGRSNGYSGPDSYDAQPGKQYYHDQYGRDGGDNARRRDDREDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCR2</accession>
    <name>A0A1B7YCR2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf1237 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158363.1">
        <property type="nucleotide sequence ID" value="XM_018300513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCR2"/>
    <dbReference type="GeneID" id="28864620"/>
    <dbReference type="KEGG" id="chig:CH63R_05538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05538"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF2">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="692" mass="75813" checksum="E1963A835045A2FD" modified="2016-11-02" version="1">MPAFTMLSGNIQTRRARIIVIAFLVIVFLLFFNNSHLGRGGGAAYLDPADAGRPPAAADKPTQQQPPPHGNQDKDGELPVAHGEPDAASDKLKADAEGGDSYRNQDENLVKQPAPANAGANGKPGDASKPSDAATTKPLPPTPPADCESFENWMRKRPGPASEGKRQFPLVRPRPECRTFRLPAMEALIERMKGVIKDPDLHRLFENAYPMTLDSMVKWRGFANETDEATGETRVTDQELTYVITGDIDALWLRDSAEQISPYLSLLEASEDHDSLAGLWRGLINAHSRYIVISPYCHSFQPPPESGIPPTHNDAYSRNHPMPPYDPKKVFDCKWELDSLASFLKMSVAYAEKTGDWQFFGKYGWVDAVEAAVNAAGAMRLGTYSAEGKVEKSAWTFTGWTDRGSETLTNDGLGNPIRENGMVRTAFRPSDDACIFQFLVPANMMWAKYLESASEIMARLEGDRARKLTTAMREQALGIRRGIERDAIVSRPGFGDIFAYEVDGYGGANLMDDANVPSLLAMPLWNFTQTSLGPVEDEKDKKATKHDYTEVYRNTRRFVLSDANSYFMKGPVISAVGGPHVGPGRAWPMAAVIAAMTAYDPISGVEDVDGEVGTQMRMVLDSTAGTGVLHESVNSWNEKVWTRAWFGWANGLFGELILRIEEAEKKKGGGGGLLGKSWQDSPASSTASSPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDP4</accession>
    <name>A0A1B7YDP4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158646.1">
        <property type="nucleotide sequence ID" value="XM_018300796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDP4"/>
    <dbReference type="GeneID" id="28864903"/>
    <dbReference type="KEGG" id="chig:CH63R_05821"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05821"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="657" mass="73226" checksum="8C81F475418D3564" modified="2016-11-02" version="1">MRLQDSQGLPRSQQYPSPNPATGQSACFPFLNCQDLSIDIRITMANQNYVDQRPVRSGGLSDHMDSRRSSMTQPHVTAYPELESPPYSVTTFSQQHQINEQHLLTPVSATGSPCIQQTVNLPQYPSAMTPMQSQTSPAGPSGMPWHHAVSMDTTQSQVGSPMSINPTTSEGQFEMSYIPAENDDVPKPPADYYWGNYLVSEQSEPEQGSLSPQMPPEYYMSHNGQHAMQPQPMVEHMSSELPMPQHAALSAQAPYYPQHNPHACVEQPDIAHFRDTATRRRQLGYHLPSTQFARQEPTVQAPGPSRPSSSESVGRVARQPRMRGRTTPPLRESTETDNIVQVQLEENVPDLPDNFVIKEVCPPEHRYLFEKQREMTLAGYNGLGMWDVITPEFNALFDVESKTSRLQMLVSRGRYKFLEMSPRDVSPSRFLDDMTSRDNRLTESQQHLALKAYGFVCQQFHKMAVLKFREFGGGQTTPWGQSDLEEFAVDMGLVEERFVPMPKDPQVKTRRLKKVSSRLRSGAYANAVLQEVAENGGGLFEQNPELHDQVTDEIFEYRGDDAEEEEEDHEAMLDMISQTSSNGSGLGIKTEDDNQSVGTTSGKAASTGKIARPRKAPAKPKAPAKPRAPAKPRAPAKPRAPAKPRAKGRLAPKSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDQ0</accession>
    <name>A0A1B7YDQ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158743.1">
        <property type="nucleotide sequence ID" value="XM_018300893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDQ0"/>
    <dbReference type="GeneID" id="28865000"/>
    <dbReference type="KEGG" id="chig:CH63R_05918"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05918"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="365" mass="41859" checksum="E505C8BC41237AC8" modified="2016-11-02" version="1">MPAELRSRFNFVSQYFFLMPGTVRFNIDPLGVCLDDADISWALERLAVGISSESKANWIRRTNTAHGIRLYKRPKDGLDLFSGGAAASLNHPLDMSAIPLSSAPPTLLELPTDLLHVIIDHLDLAAEFHLSQTCRALRHLTHRDWKTLIPCLPYREILPFYIGLAYTRPDHWACERCCRLHRIPNISLAPRFGQSQTCGMRTDWTWPEDPTDLWHEASPRIVGDRFLLRKKTYVPIWTSVAAVNVCPHATLVSAGGHGMIPFLVDRFCNPEYVRDELERALRNLGREVSGHCNYCPTDYSVVASVDECTVTAWYDFGSYELVRYYMWMTHCESPSHWLLNLDKLAIRHVPGSVRELYFRDLKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEZ5</accession>
    <name>A0A1B7YEZ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159190.1">
        <property type="nucleotide sequence ID" value="XM_018301340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEZ5"/>
    <dbReference type="GeneID" id="28865447"/>
    <dbReference type="KEGG" id="chig:CH63R_06365"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06365"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="477" mass="53303" checksum="A262A422DCE38F0F" modified="2016-11-02" version="1">MDPDYAKSPQEGSQIERHLKYQDKTLAETKARANLFLDGDGDPMAFYHSSPAAIGGILTEVTTLHGMPLPEGPRTAELLRFYIEVVAPNMVSIDGQSQPPVFLAEVLPWMLQSPLFPNIGILMSSTTQALERGSEISKNPESLALKARVLSIIAEYMQRPFDAIAIEMVRSIVNLVVMEASEQWFWGADESMFAHMRGIKHMIKLKKGMRGLGDIVGESIMILTDYEIACAFETDLYWLENDPARDEELPVPTTWPDCYDSPLMASSSRFESIAGKLGLCATAAKILDDVRFLTVSITSQSASSGWTCKIRSTATWLYNRLRDRDTVGPAIITSEEEWILETVRIAALIYSWSIKSMRQISRFDDNETLEAAYQALTSVSMTTWKRIPGVFLWIMLVAAPNAAPDAKGRFVRRKMAVTGLSIGFEDFGLGISYLKAFWSFQQWIAKEGNTGVQRLDDKWSSTLGREARSSHKSHESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFT6</accession>
    <name>A0A1B7YFT6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159470.1">
        <property type="nucleotide sequence ID" value="XM_018301620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFT6"/>
    <dbReference type="GeneID" id="28865727"/>
    <dbReference type="KEGG" id="chig:CH63R_06645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06645"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="532"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1279" mass="137979" checksum="D06287719CCBF722" modified="2016-11-02" version="1">MPILDITKDLAALFEQQAKATPDALALEDESRTLTYAELDQETQALADRLRRHYGVGRDSLVGVLMSRSADYVVASLAALRAGGAFLVLELAYPSGLLRDVIQDAKPTVVITQNAHVNHIKADVPVIVYDEPSKTTVNGHANGELSPLPASDDLDRLAFVSYSSGTTGQPKGIANPHRAAVLSYDLRFGLSDLQPGDRVACNVFFVWEMLRPLLRGAAVFAVPDSASYDPSALVNLLDSRQITDTLMTPTLLATVLSRHPDLSKRLPKLRSLWLNGEVVTTDLCRRAIKALPETRLLNVYSASETHEVAAGDIRTFVDFETRVCPVGPPMDPEHIYIMDENGNRVGNNVSGELYVGGDLLARGYLNLPETTAKAFHPDPFVKKEGARMYRTGDLARVLPSGLLEITGRAGGMIKTRGYTVQPGAVENAIVKHLAVRDCAVSSHGEGLERQLVAYIVRDNEDKRGRADVVVDESGYSPAARRVLGEHLALYMIPTYWVELEELPTHGVSGKTDLKALPPPPSPKLATNGEKEQNTKVKLETVKKLWAAALNMPDSAITEEHDFFDIGGHSLVLADLANRFTKEFGFPVPLAPLAGTPTLQGHLQAIRDARDGHTAAVQADLPAVLRADSILPEDIQSNGTSMRRLNDAGTVLLTGATGYLGAFLLKNLVETTSAHIICLVRFTDPTDDMRPAGMARIRKNLIDLGIWDDSLLDRMEVVPGNLSREHLGIASDVYDDIVSRVEVIIHAAATVNLVYPYAALRSPNVGGTREILRLASKSGATLHHVSTNGVLTPSVAGWSEDAMVDIDDVPEKLIDGYGQTKWVAEKLVYEAARRGMPCKVYRPGTISGHSNTGSCNAWDLLNALIVESLHLKTAPHVDGWFAEMTPVDFVSAAITTLANHTDPNQLVYHLGDPNPVSANYIFDSLNELGFPTTRVPWDDWVELWTKKRGFGTAGDVPFTVDILRGGMPTAEALQAVTVLKDDATAPALALYNLPRPKIDTNLLETYTRHFCARGWLSRPPRRADANGATSRVTKGRLAGKVAVITGASSGIGAAVAAGLAREGAHIALAARRTEALETVKAKLVGTGGKVLIHKTDVTNKEDVASLMQAAADKLGPVDILVSCAGVMYFTMMANNQTEEWERTVDVNCKGLLHCLSNTVPGMLSRGKGHIVAISSDAGRKVFPGLGVYSASKFFVEATLQSLRLETAGTGLRVTSIQPGNTATELLGMSTDAEAIKKYGEPTGAKVLDPEDVASSIVYAVCQPEHVAVNEVLIEPRDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFX7</accession>
    <name>A0A1B7YFX7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159301.1">
        <property type="nucleotide sequence ID" value="XM_018301451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFX7"/>
    <dbReference type="GeneID" id="28865558"/>
    <dbReference type="KEGG" id="chig:CH63R_06476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06476"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="161" mass="18762" checksum="AA1D20867A9461BC" modified="2016-11-02" version="1">MARGSLTCKRPAARLLLAVGLLALAGSFVFGIDREYVPRGGERERNGYNTGAKCSRAALENKNKNKNKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKRASLCGKLNPAVDEAPEPSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGI0</accession>
    <name>A0A1B7YGI0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AGC-kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_06875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159700.1">
        <property type="nucleotide sequence ID" value="XM_018301850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGI0"/>
    <dbReference type="GeneID" id="28865957"/>
    <dbReference type="KEGG" id="chig:CH63R_06875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06875"/>
    <dbReference type="OrthoDB" id="5413172at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="157" mass="17955" checksum="A41469BB643D389D" modified="2016-11-02" version="1">MSSPSSSEPVSIPVVVLGWKRTNGVVYVPDVLAERNAPYVMTAMVDFVETLEPYRYTPKNLGVILHNLHPRPRALVVGTAVPPSLTDEITTVWNEYVDTVLKEEFPGEEWKKNVCSHLQLFHYVSPETTKHPPKNIGWEREMLRQLDAVFRPEVTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGK0</accession>
    <name>A0A1B7YGK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159720.1">
        <property type="nucleotide sequence ID" value="XM_018301870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865977"/>
    <dbReference type="KEGG" id="chig:CH63R_06895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06895"/>
    <dbReference type="OrthoDB" id="4835412at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1336" mass="145484" checksum="FD9EA1193882EDC1" modified="2016-11-02" version="1">MASTSNPVMNGLQNGQPDLDQDRRRWFNDFEAIKARFEAEKETIRSKFLQQQRDACTDLDDEARYADMPGLPQKAHDLIQKYQNELRSHRWAACQHRFDEEEKDRVQRERDALREHHILFPIPGPSGPNGHNGPNARRPSTTKTTIATLPSQTPPNGRMALPSEMLARATPSSSLANTISQPRQPLPQGGTGMPSHTTHPNQHGLSRQANGASGDASSTQMQHQQLLNQTRQPQQPMGQSQRNPHNQLNQHNQHIPHNPNWPHHGQPGPQQGSPRISPIYQNRPVNGSTVANGPPRVLASQVQLPMLGSNHYGHMRIKPSVRPLTGGDPADSMHGNRVPLPPIHTPAMGNRDERLQAHNGRNMTQLPTPRADDMARQAMDIHRLAKRKSDASDMSAREAEFKRARLDSPHSIAPRTITFQEVYQDGKAEFKHNIVKYDDVFYILRCDEHGVHFKQNALAAAAKHLHGASHGHQKKEHKLAVETIGFHVVDCTEELAALNNACVRQAFENGYKPLNQLHGPKSGGKRHSGGIPAVVDAFVDRAPSVSQSPFQAPAQAAALENVAEQDETEQERQQEPKQDTKQDTKQDTKQEDSMPTKYILNPKAGELYHARWPRSSKLYIVMILGWTDLRMCGWEAKLSETQLYDKKIRPSCYTYNDDGIAGWASGFGDGEPRVLERDVPVLWFESKGKTRLGWLGVKWLLKPMVLDDPSRPTDPDNPSNQARKTYAEIRGYDSFEAMLAASGTEGAVPTTTKVPSSASASDSDSTPDVDMYDFGDNPPAVDDSDDEDYVEGRSRKGRPTEDGGDEDDDETADADEPPVTPQPLRRSTQEVRPSSRLGGGGWPSSRMGAAAGTRLSARKDKSTADNKEDVTMEDALQTTPLRNRSTGDATPKAAGKDEGLLPSVALGSPADPVKGDNIKVAESDTAARADSSASENSVFPPGSKSGPAERATLSERSRSNPYERCNAEEGPETADAKTARDGEKDAQPNHAAAMAKLAQSAMKAASKSPSLDREAAQISPVLQVANLLNSAPAPEVTKQPSSGASQAKPNDARRPLPSGPGMTVIVAEPATVPRSSMSHDMTTGGSIGVRKEDANQQPSVDLTVQSNQEAETQPARCGSAGSGDSAARRSDPRMSISNAVDDHKDEGIKRTEAGLLERNATEDGNNGGLSGNNTSRILAHIGLANDARWRAVRTSESPQMSAAMVQSPVIDRGEAASPALSGKKEAETSIDVAEFHEGDMHWAQEGKFLRFVLEDESSGIARSVKEDGMEVTVDASQVKAAQMAGSEVRLVLKTGGEQRLVFSANALTGSHRGARMQTAKFYRWVTGRNTDIEHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIM1</accession>
    <name>A0A1B7YIM1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160349.1">
        <property type="nucleotide sequence ID" value="XM_018299103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIM1"/>
    <dbReference type="GeneID" id="28863210"/>
    <dbReference type="KEGG" id="chig:CH63R_04128"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04128"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29285" checksum="ED35BF5B4B0682DC" modified="2016-11-02" version="1">MTTQPAPFFARRAFQHDLFRKHPRFWDGLRHFGYQKEERFYNGVSMDEVHAVDEAGRRSTVNGIQDQLFRSCSHLLVLFRSRPAWQKHGIIGRGILVDYHTWRLERQIPYDPFARDSIPVSDLKACLEAQGTEVKFGDILLTRTGFMTAHAGKSADDLETYRAAMPQTSGGVAQSEKTLRWVRDNSPAVGGDQPSFECWPHRDPEHWMHEVLLAGWGMPIGELFDLEALAERCRREGRWSFFVASKPCNIPGGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIY4</accession>
    <name>A0A1B7YIY4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160576.1">
        <property type="nucleotide sequence ID" value="XM_018299330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIY4"/>
    <dbReference type="GeneID" id="28863437"/>
    <dbReference type="KEGG" id="chig:CH63R_04355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04355"/>
    <dbReference type="OrthoDB" id="3941683at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="34081" checksum="E71DA18EAC658D61" modified="2016-11-02" version="1">MVNRYIFAVAGLAAQLNALPLNINLGAYSPALVVGDGEISFGGKSDVSQLMNVLEGAAVNAAQGAANAPAAAPAAPAAPQQPQQPQQPQQQPAAQAQGGAIPVSATSSNNQVNEAQAIAALQGMGKEIAPRVQLTKTRAAGDKRDLSGFDRALKFAEVALTKGPKIQLGTGQEGSGVGMIIDNNQEAAARPGTGTGGGAEARPPAQGQPAQGQPAQEGQRPAGSIVAQQKVKARSDEAQQPPRRRAKVTTMYVRSGVPEGVAMTPEKLVARDPSVPVAQVVPATSNNVVKRAQEELAARGVSAGAIDTVNLNVSGEGVTMTFVETQADDVEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJG3</accession>
    <name>A0A1B7YJG3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HypA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160551.1">
        <property type="nucleotide sequence ID" value="XM_018299305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJG3"/>
    <dbReference type="GeneID" id="28863412"/>
    <dbReference type="KEGG" id="chig:CH63R_04330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04330"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="544" mass="62123" checksum="C0787340167D8716" modified="2016-11-02" version="1">MGKHPIPITARSLSLSPFRVCLICKPVILFVTPPCPRYLRFCYLRPATLPGHPNTCLSAMKIRSSSTASRRISKIIVFSGKRTYSFGQTRSINMATPYKIQVPVTNTGLWKFKQQDDTANKVSELLQEDLKKHHVFFNQDGFHNHIPHHLLALFGTGAGPDAIQTAYNENANYQRPAKESQDSVADELHDWEKTKKYLGREKHYSDFLLFYQREIERLGWEAALNEHLFKGDERANDMFQRMFAGFLHPIIQLMYGVEWEQPAIVAEGLAQAAVHKNQLKAFLDETERRADETAKTPMPQIAALIEEIRDDQKLATAAEMGDANKIFDGVMKRAPEEMLRVASKVKVLPEELDERTAEMFHIAFYVAGGAALRPGKEAKWDFFLIHHTNAAPIFLSFNSKPWISTENKVRMLEHKIRMDLVQYAARGCPELRLDQVRSYKPRDRDQGKELVSKPSDLLPRFHSIPDDGHTIKVARALGICHDLSSKYGDKPWIKMQGDDEWLKLAYMLLDGTEHSGTRWVRSAGFEEAWKVSGKIPLTTHETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKE3</accession>
    <name>A0A1B7YKE3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_04796</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161017.1">
        <property type="nucleotide sequence ID" value="XM_018299771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKE3"/>
    <dbReference type="GeneID" id="28863878"/>
    <dbReference type="KEGG" id="chig:CH63R_04796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04796"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="174" mass="19403" checksum="5719AA41CF5E6A37" modified="2016-11-02" version="1">MAQTSTIVTASVAAAVTGLVAYAAFFDYQRRNKAEFRRELRRNERKQHKAEKEEAEQETVRQRQAIKRAVDAAKEEGFPTDVEQKEAYFLQQVSEGEVLAQDPTRVVDAALAFYRGLKVYPTPGDLISIYDKTVAKPILDVLAEMIAYDDSLNIGQFQGSVNVDLGNMPTVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKY0</accession>
    <name>A0A1B7YKY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161065.1">
        <property type="nucleotide sequence ID" value="XM_018299819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKY0"/>
    <dbReference type="GeneID" id="28863926"/>
    <dbReference type="KEGG" id="chig:CH63R_04844"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04844"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="183" mass="19421" checksum="B6929C72721173D1" modified="2016-11-02" version="1">MKHIASIIGNPSLALLDPSVFSVAAAAYTAVNERCTSILGHPPCQLFTPKLGPASRTCSRLPFPPPSHPVVRWLAAPLLLSIHHTQYSVTQSHDHGPATAAASQLAPVDPPIELCHARANYNSIRTATAVFWNACQWPPSVTGAVDDTPYVTPDPALCPAIPRLNCLLLTYIAFSIQAGLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKZ6</accession>
    <name>A0A1B7YKZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_04981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161202.1">
        <property type="nucleotide sequence ID" value="XM_018299956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKZ6"/>
    <dbReference type="GeneID" id="28864063"/>
    <dbReference type="KEGG" id="chig:CH63R_04981"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04981"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000468">
        <property type="entry name" value="Related to single-stranded DNA-binding protein MSSP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="269"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="565" mass="61099" checksum="AC51FD922892AE2C" modified="2016-11-02" version="1">MSYQTQTMDPKHTVAFNSAGNHHMSGNHVAQFPENQLPGMMGSVDALAGTIGQFQGMTLGNGISHSASNMGQMAAAHTYMLPQDYMLAPHLPSAMGMDHLSQGPYGPAAGGYLAAPGQFSPYMPYPMMPFTPGRAVSGGAALLDRTNRGHNDLPGLENRRHSGGSYTTTESAPTTPFYNGGGKNDKGPRVAALDRSTYTTPSPQQVVGGNIFVEPAAKHSAINIPVDRNLEELLKQDPAVPKAVPAVFTPATQMKTLDQSLENRIPGNRNVYIRGLHPTTDDDLLFRFAARFGNVETSKAIIDTSTGACKGFGFAKFYDVRDSEMCIRGFHRLGYEVGFARESFNSRLKAEGDEGSTNLYISNLPKSLTENDLGDIFGGYHIMSSKILRDSMGNSRGVGFARFESRDVCDTVIKQFNGIPVGEEGMVMNIRYADTPSQKELKRVTAERRQFRTNEYNIGAYGTPLVGIQPNMYNQPAWKRALHATANTGYTPRSMTGGLDRMGKVVKSDGYQAGTVQGNPQSSVEATVIETASDDSDEGVTIHADSITPVIVSTQSSPILKKEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL99</accession>
    <name>A0A1B7YL99_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161340.1">
        <property type="nucleotide sequence ID" value="XM_018300094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL99"/>
    <dbReference type="GeneID" id="28864201"/>
    <dbReference type="KEGG" id="chig:CH63R_05119"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05119"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601751" evidence="6">
        <location>
            <begin position="19"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="603" mass="64422" checksum="DFAD721255C7F628" modified="2016-11-02" version="1">MLSRSTFVALLLSGRVMAAATCKTTPSDASWPSTDDWNSFNQSLGGALIKTQPIAASCYENSSFSSPVSCDEVNSNWFSPALHARFPESIDYPYWANNSCVPPSDYAYQNQGCELGGLPEFILNATTTEQVATAMKWASSRNIRIVLKGTGHDLVGRSSGAYSLSIWTHHFQSIELNSQWPRPLGNGTENVAIVGSGYNWGQILNATAAVGRTLVSGQVSNVGLGGFIGGGGHGPLSSHYGLGADQVLQATVVTSAGEVLVANEAQNQDLLWAIRGGGPGLYGAVVEYVLRTHPSPENVVLSTLSFSMAGNDTQAAILASWNALATISAALPDLMDAGIAGFGSASTTKVYTTSSGALGQGITAIFTFFGYNTTERAVSSLLAPLKLSMLAHGGDGALSVDLSEPEVFSTYLSFFNDNLNIVETPVGQISISSSRLLGRRELTEISLDQLRTHLQSLMETQVDGASAALVYGLQGGKGPREVQEHMRGALNPAWRRAYIHLISAASKVNTTDTTPQEALDSAAAWTEEIQEAAWRKWAPGSGSYINEANPFNSNFREDFYGESYERLLEIKKKYDPTASLFVLSGVGSDMWKYDLNTGKLCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLB8</accession>
    <name>A0A1B7YLB8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_05132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161353.1">
        <property type="nucleotide sequence ID" value="XM_018300107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLB8"/>
    <dbReference type="GeneID" id="28864214"/>
    <dbReference type="KEGG" id="chig:CH63R_05132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05132"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="114"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="580" mass="64419" checksum="F5CA81E925B2BD2A" modified="2016-11-02" version="1">MAEIVVCCIYWFVLKARRRLPFGYLSLLSLCLLREKPKPQRHEPEPPAMDNTVSKTGDGVSQHEHRTEDVEQLKHQGQNTARGADRAANLIGDQQIELTEEDNKRIRRKTDKRILSILIWVYFLQILDKSVLGYGAIFGLREDCNLTGDQYSMVSSVAAIAQLAWQPFSSWLIVKVPHRLLMPCLVLGWGIAQVCMAACHNYAGLLATRFLLGLFEAGCLPLFSVITSQWYRRAEQPMRVACWYGTNGLATMFAAAVSYGLGQIDGAIHSWQILFIFVGLITVLSAPLVYVVLDNDIPSARFLTEHEKLQAIERLRANQTGTGSRDFKWSQVWEALYEPKSWLFIGMAVCLNVTAAVTNTFGPIVISGFGFDSERSSLLNIPFGFVQLIVIFPASYLAHRFRIKSAFLAAILAPVLAGAVMLYVLGRDNVPPLLAAYYMLAFLFGGNPLIVSWMISNIAGTTKKSVIMSLYNAGSSAGNIIGPLLFNSRDAPEYKPGLTKVMGITCALLAIIGLQVVNLVVSNKMQERKRVANGKPRKIQDLSMEHRYTTAQNDGSGAHLGENAFLDMTDSQNDEFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNB4</accession>
    <name>A0A1B7YNB4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162064.1">
        <property type="nucleotide sequence ID" value="XM_018297248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNB4"/>
    <dbReference type="GeneID" id="28861355"/>
    <dbReference type="KEGG" id="chig:CH63R_02273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02273"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="189" mass="22010" checksum="FB1F6A21FCCCA4E5" modified="2016-11-02" version="1">MQVRHRNTVDRLDRPSAYYHNKASQNKRRRPDHRDARDAEDEAASKNEPLPEDPLANATTLYVGNLSFYTTEEQVYELFSKCGEIKRLVMGLDRFNKTPCGFCFVEYYTHQDALDCMKYIGGTKLDERVIRTDLDPGFEEGRQYGRGKSGGQVRDEYREDYDEGRGGLGRAIQMQRDRDDRMGDYEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ01</accession>
    <name>A0A1B7YQ01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162628.1">
        <property type="nucleotide sequence ID" value="XM_018297812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ01"/>
    <dbReference type="GeneID" id="28861919"/>
    <dbReference type="KEGG" id="chig:CH63R_02837"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02837"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="608" mass="68328" checksum="AB21AC1114B4A2C8" modified="2016-11-02" version="1">MDRPEPGLIKWSQIPGHDSFIHINLQHRVVQVYEPNGLAQRSRFDYKRLSKHDDFPTLTTYDWSPTVPGLLAVGTQTGVVNLLRMDDNSNAYIELNLKMTRTCQAVAFSTEGLLAVGLDRVRMDQCLHIWDVNRLSTMNKTAKGFPKDLHAFTDPAYRLEPSVSVSSVKFFEDSPKTLVVGIKAQGLRIHDLRDYADQNYFASSALDQPGIMIWDRRATSRPVASPSYLGAVDEDDLPWGGALKLDRVVEMDDDPSLSESRHSIVRSLRYCRDHRGLLAVLSRSGQLKVLDTNKEITHRDMTLEGSPELLEVHKSYDMDVQYGDSGRKNDRIVSFDWVTLDSAVLQPRLVILRANGTFEILEQPSYTSDYLYKLTPWQPPHRGLEEGSEYHSIMEFEPSHCSDMLGPLFVKEALSDIPIFGPNKADIQSIVDKTLQSKFSAADLNGKLIGNADKASPAVDKSRPTAERMRALRLELKEKAKNSETNGAESSAMEESISSLAQLSLSKEGPVSCRHMHEHLLSLPLKAPDLSTEAQCLLDHVMLLRAKEKYLFDCNINRVVVSDDPWLRYVWDWIADAEDAAFDGGMKLSPLDLSYMGVCTIWTDDLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ59</accession>
    <name>A0A1B7YQ59_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162545.1">
        <property type="nucleotide sequence ID" value="XM_018297729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ59"/>
    <dbReference type="GeneID" id="28861836"/>
    <dbReference type="KEGG" id="chig:CH63R_02754"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02754"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="16027" checksum="3826C92BAE711DEE" modified="2016-11-02" version="1">MSARFDAVLRGGGDGFMVECIPQGACGTYGGYVYGCTCDAMQTQLASWRLRGICGLRFSRVFEPKQKCNVGSPIRTNLAGSEPEMLHKHFLAARETPGSQTGSMQSITTAAILGVERGHFTRPFRRTTSQAPLAGADAAGDWSPPAAVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRK3</accession>
    <name>A0A1B7YRK3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_03244</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163035.1">
        <property type="nucleotide sequence ID" value="XM_018298219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRK3"/>
    <dbReference type="GeneID" id="28862326"/>
    <dbReference type="KEGG" id="chig:CH63R_03244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03244"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601863" evidence="17">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="446" mass="49291" checksum="27F349B4E8892D3A" modified="2016-11-02" version="1">MLATRVLGFFLWSHLGLVSAALQLGLEGIPNCAVNCMLEALPETNCSPVDQACLCADKKFSATVEPCVRSLCTIEETLVATNGTWSRCGFAYTDDMTKIRWVSGVVTVCASIFMVMRLTTKVAKLSTWGADDTVAVVAFVGRASCSVAQCVLSWANRGGKKVVIVGLYVESFYFAEAGLGKDIWTLLPDEITHFLKLLFVLEFFYLVGLAVIKASILFFFLRIFPERRFRRVLWLMQVLNMLVCLSFVILCFAQCRPFSHFWTGWDGKHEGKCLDLNKIGLSHVALNIVLDVCMLALPVTQIYKLQMDRRKKIGVIAMFQVGVFLTVVSILRIRTMRDFATSLNVTADSVAVVLWAYVELGVGVVVACMPNAWQLLKMIPSKVTQLTTTVTSNIGSSVSRTRPNSQVFPEKPRKVSMAETISNRSETVVPSASSSRRASKNSEPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSA7</accession>
    <name>A0A1B7YSA7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163359.1">
        <property type="nucleotide sequence ID" value="XM_018294997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSA7"/>
    <dbReference type="GeneID" id="28859104"/>
    <dbReference type="KEGG" id="chig:CH63R_00022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00022"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="535"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="887" mass="96878" checksum="8934C11937B13DC4" modified="2016-11-02" version="1">MDNTSYDPTSIPPIPHRYRNLQTPEPHPRRRSLPPPSRRAADTVPSSPEVISSLITSLSVISTPADNHFERSQPSLSLPVSPRQGSFGVDYGAFHQPSLENLRGDNNVPLDEVAAAAPVIRTAKPPSGLSPLTAPKSPARDASGGLKSLLRSSSRPSSKGSLGSRDDAQSIGNLSIERGSAPTPELRRQSSFDSWGKKQGRSHRGLMYMSSKERLREKEEKKRASIGDRSSSSFTGASLRPDPFLAETPISEEPAHSPESPTRESPRKLEMASPSLDPAASPRPIPARDSSLFKTGANAKRTSTRSSRSKRESGNGNNDIIFEGEEQIPLGEVPRRKHLSRHASENDLARVSADTSVRSFSRPLFQSRHTEDFRTRGPLVEEDVEDSAPFPAVAQGRRREEQIADRNRRKPGRDTPEAGEAIKMKRSSSRLKRLSQPLSPKGEESASSRNSAASPDHRNSMPAGYERPRSADSIDDAVESYLCSPRLSQKIRHPQTGRVISFSEVGDADGSAVFCCVGMGLTRYITGFYDELALTLKLRLITPDRPGVGDSESYADGTATPLSWPDDVYAICQALKITKFSILAHSAGAIYALATALRMPQHIRGKIHLLAPWIPPSQMNVFGTSQALPPTNAIPTSQRILRALPATFLKAANSSFMSATSSSITSSLPKNPRRSKRKSTVTTGRDTPATHGSKRDTTPHLDKENLGLYDQTSAGDDLSGRPAQTAMENMDRIRPTGTASAQGHYDADAHAMAAASDALMDKERQTIYDTRLTHAIWELATTGANPAVDLLVCLERRHTIGFRYVDITRPVVIHHGSRDTRVPVDNVKWLGKTMKRCEVRVLEGEGHGLMASAGVMGAVLMEISKEWDDWLRATSKKDDRGRRTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSM8</accession>
    <name>A0A1B7YSM8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163566.1">
        <property type="nucleotide sequence ID" value="XM_018295204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSM8"/>
    <dbReference type="GeneID" id="28859311"/>
    <dbReference type="KEGG" id="chig:CH63R_00229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00229"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="204"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="664" mass="73346" checksum="7CE22693CC8A90BB" modified="2016-11-02" version="1">MDTASSSSSEPRLRNSCESCRRSLGETGRSVRVLTELCGLSSGSKERVRRLETQVGQIYEILQSLTENRMRGSTASPLAPVPNRDDEASLGNGDDAAVHNDASEPQGSFFDPTASPEPPPDALEHLIRVYRKDIAFKPLPLFGRSTLRSRLSSPTPRFLRRSFLALTLRFGTHPFFRGKEGECADFYAASAYADLMPLALEGVATVEVVQSLCLLALQDLKVCKPARAWGTIGMAARLEVSRGWNRRELGQAAQDDSEDDESSRCFWSVYILEKAFSAQCSVLDRCVVQPRYPDSASLSLQPPPSTPPPTSTEGQAGRFDGINSSFLRVISIWGDVTSYNHGVRCSRRERPWLPTSRYTELTQKMYEFEDQTALKHLLKNAAFTDRTPADVSENLEYWRPWVLMQITHHATSAVLNHPFIHISGLGEASRRQPPRLFMQGVIDQAQYHAQWVGRLVQMCEAVQFDILDPLLGTLVAATATVAWVFRFAPDSSAASKSVACFDICEGFVRKVAASWPHIGQKVKLLESLRGVSGQTRGDGDSVITFRPSKLWELLDNSIIVPKPSPHSNITSSESNSRRESPLPDATLSVTTHILHPVDEDAEAAAQSQPVSPATTDNNGTDSAAQARPGDELCFDDFFSQYLPTEMNCAPEAVQVPMAWQNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTC5</accession>
    <name>A0A1B7YTC5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_00467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163804.1">
        <property type="nucleotide sequence ID" value="XM_018295442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTC5"/>
    <dbReference type="GeneID" id="28859549"/>
    <dbReference type="KEGG" id="chig:CH63R_00467"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00467"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601914" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="580" mass="62486" checksum="2607A4EEF887A972" modified="2016-11-02" version="1">MKLLDIALLGLIPALITLHLLVAPDTKVEESFNIQATHDVLIYGTPTHDVAARLRATYDHFEFPGAVPRTFVGPVLLAGLGGPVVNLVGFRHAQLVVRALLGLANAAALLVFARSLAKGLGMGVMRWWVLLLAGQFHVMFYASRTLPNMFAFALTTLASANLLPSPSSKSHSARLRVSISLLVFAATIFRSEVALLLATTGLYLLLAHQITIPRLIRPFLISFAVALAVSVPLDSYFWQKPLWPELWGFYYNAVLGSSSNWGVSPWHYYFSSALPRLLVNPLTLLLLIPLALSHPAMSHIAAGLVVPPLLFIVIYSLQPHKEARFIFYAIPPLTAAAAQGANHIFTRRSKTLLYALVSVALVISVLASLAASTGMLLLSSLNYPGGDALHQLHTLVASDPSGSGGSVTSVHTDVLSCMTGVTLFNQNPGGLPKNSHARALESSLRDGAPASAMSWGPILTFDKTEDKAVLADPAFWSRFDYVLAEDPASIRGGQWETVGFVQGYAGVEILRPGSGSLYGGGDDEEEGEGKVLGRGLVVKRVRDWVRGLTGGWWVGPRMESRIRILRRTKDAGAGARIVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTJ6</accession>
    <name>A0A1B7YTJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163878.1">
        <property type="nucleotide sequence ID" value="XM_018295516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTJ6"/>
    <dbReference type="GeneID" id="28859623"/>
    <dbReference type="KEGG" id="chig:CH63R_00541"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00541"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601919" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="203" mass="23351" checksum="8F7B35898D9170AA" modified="2016-11-02" version="1">MFFPSVAKLLLAAGFVHSALAHNIQLPAHGRECFHESLHRDDKMTVTFQVGDREFGSAGNLDIDFWITNPQGQYETFDKSVSNGDFSFDAKHDGKYTYCFGNEHWGAHSKEVSFNVHGIVYVSETDVPADPLETEVRHLSELLAQVKDEQSYIVIRERTHRNTAESTNSRVKWWNLFVIGLVVGESVFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU01</accession>
    <name>A0A1B7YU01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydrouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_00612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163949.1">
        <property type="nucleotide sequence ID" value="XM_018295587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU01"/>
    <dbReference type="GeneID" id="28859694"/>
    <dbReference type="KEGG" id="chig:CH63R_00612"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00612"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="37"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="400" mass="43977" checksum="4768087F5F8175A0" modified="2016-11-02" version="1">MAAELYNGTISDRTHPLKIFDAAKSQDRFLYVSAPMLAFRQTVHEYGTDICWTPMILSKEFNRNNFARDSGVFSISPSRPPPLAQPADQGTARSHDINTPLELARSSSLAAPYVNGVDLNCGCPQSWACAETLGAALMEKRELVRDMVVETRQRLASDGWHVGKERDVDSPKGRSISVKIRVHKDLRRTMDFIDTVVGNPQDRNIDFLTIHPRTRHTASSIPINTESLGILLEKYGDTLPILLSGDVFSMATLPLSTVSKGPAERTPEPTTIDGHNGYADFTPSGTELAGLMSARGILANPALYAGYESCPWEAVESFIRHVVRAPIPVKLVQHHLHEMCGPGMGPDKRALLNRQERAALLALDSMLDVIDFMDDAINRKTGRTDGLRREPVGSSTVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUG8</accession>
    <name>A0A1B7YUG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164212.1">
        <property type="nucleotide sequence ID" value="XM_018295850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUG8"/>
    <dbReference type="GeneID" id="28859957"/>
    <dbReference type="KEGG" id="chig:CH63R_00875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00875"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="302" mass="33363" checksum="BECD13B4CF2F2E15" modified="2016-11-02" version="1">MSPSYESECHDKQVAFTDESGDDASLSEITGPAIRMSRWERLKNLLLYAIYSVFLLSYMLLFLAYTKSVNSRVAVDPSRMGLEGIPHVTVPLGASVAEARLASHKSLTVIGVYGDAPLGSHRQILQKAGFHDGPPNAYEGRPTAENDAAWADLMSVGMISISEAENARLPMGGSAQVRDANGLVPDKYLVQTSVSHQLHCLKRLRELIWDSGKGLAEHWQYGHGSHCIDYLRQSLMCHGDLTPIYMMWSEEHGSFMGVQENIMQCRSWEAIVEWSAARNDTGMRVDGNHGKNTKTHGLVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVP1</accession>
    <name>H1UVP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clock controlled protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00747</name>
        <name evidence="3" type="ORF">CH63R_03619</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000302">
        <property type="protein sequence ID" value="CCF32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159840.1">
        <property type="nucleotide sequence ID" value="XM_018298594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVP1"/>
    <dbReference type="STRING" id="759273.H1UVP1"/>
    <dbReference type="GeneID" id="28862701"/>
    <dbReference type="KEGG" id="chig:CH63R_03619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03619"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015714_1_0_1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="738" mass="80056" checksum="CB00C4293FF58E35" modified="2012-03-21" version="1">MDLSQSMSRSQSQNHMLHGPAPRDRQLPPSSSSVALHSHTHHHVHPLPPAAAAAAAAAGTAVPSTSRTGTTATVVATATAAASACASAPASTNISSIPGKHVLSHARFDPTHISSQLPSYAPAPSYTHTQSHDPNLLSFPDAPTTELAPILPAAKHTDNGGHNLPSLSSVTGPPPPRFPPITSSQTIEQQQQQHRRQQQQRPPLPPPTSPQQQQRQQQQSLPKQTQPHPPSLVRSKTTTVPVTHWPSLNPLTTYYTPSHAQSADSPARMDLDVSSNAAMSAASPDRFYEGRAASVSLDDPDVRMAAEALGDLRADFINSPPARHTPLPRASPSVSITSNPQTNSEEPLFSLLTTSHPLLATTIEGATSAYNNSKNFSPRFKSSAEYVEGYLTPIANTVGTVGRKTGVEGGVRWFLGAGRRHQSTDLEAADGGSHKRRKVDTGEDLARLMIDAQSNVMPDVDSPRDPYVFKHDRRLSRASTIDTLPAYDDYRSPAYTENEKSERPTSSNAAWQSRLIMSTSGLSVAMSEESLRSLKYCLRWLRWANEHIGGVINNLKSTLEQYEKTGDSQQAQQPEVSSDGDHVMIDGQPDSISEQDRTMLAARIASLKGDVLKTLRDVIETVSKYAGGALPDNARTLVRRHLTTLPQRFRYASMVEQQQGEKTGEQAREEAMREGAHRVLVLAKEGLDMMAQVSGVLDGTIVSAEEWCERLGKKKRDQRDAVLPQSQPHEVDVKIAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVP5</accession>
    <name>H1UVP5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nulp1-pending protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04504</name>
        <name evidence="3" type="ORF">CH63R_10416</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000303">
        <property type="protein sequence ID" value="CCF32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154814.1">
        <property type="nucleotide sequence ID" value="XM_018305390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVP5"/>
    <dbReference type="STRING" id="759273.H1UVP5"/>
    <dbReference type="GeneID" id="28869497"/>
    <dbReference type="KEGG" id="chig:CH63R_10416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10416"/>
    <dbReference type="eggNOG" id="KOG2422">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008321_1_0_1"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="728" mass="80921" checksum="36FDD22C7F39DAF6" modified="2012-03-21" version="1">MSSRQLRKLQKQRELEKLQEAKSAAEESSDDEPEPVPMKPRQSLFAALSGADDNNDDEESDDAQDAALPESEPEIAPQPAKKKNKKKKKAKKAAKLDESAKNTEDKEDEIDRALKELSIARNAGSAASDNLAQRSRDVDELLQINTQYLRAINEMRALFGKDAIQAAQEEERAELEAARRAQRGPNQHVDLETALRGDPRKKLPEISLRRNVFIQGKDTWPRATAAGLVMKEIRKGSDGLTEFAFVHEQTYDNVQIMFFSCVQLGDPMQMVQLLMRFPYHVSTLLQVSKVAIQDQNQALAADLCERALFTFGRATTSAFRQKLEQGKARLDFRRPENRELWLAGYTYLKSLIRKGTYRTALEWAKLLFSLNPNDPYGMKYFIHTLAIRARQAQWLIDFMTTHEFVSDETDDTYLKQTLVLAKLQVGDTDGAKVAAVAGMERLPWLYCALFQALNVEAPPPLWGVRPDTNEREFWTNLYIHQAKDIWNNTQAIDLLKEAVKMAQKPSQALPEDMPADNRTARWTWLEDTPSLLSGIPRAMLAREPNYAFDPLPPPKEENIFTSQGVQMPWRQGGEHGEDGMFAQERALMNLLRRQQERAAARGGAGAGAGGAADMGAMGGAGAMGAMMGAFPEDDDEGDDFGDAWEGAFSDGDDDGLEGDGRQLPSAGVVQRLADMLASMIPGGWPAEPTGESDEHSNAGDDEMPSLVDADEDIGDGEARQQRGGHQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX09</accession>
    <name>H1UX09_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04886</name>
        <name evidence="4" type="ORF">CH63R_14415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000447">
        <property type="protein sequence ID" value="CCF32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150632.1">
        <property type="nucleotide sequence ID" value="XM_018309389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX09"/>
    <dbReference type="STRING" id="759273.H1UX09"/>
    <dbReference type="GeneID" id="28873496"/>
    <dbReference type="KEGG" id="chig:CH63R_14415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14415"/>
    <dbReference type="eggNOG" id="ENOG502RUI7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027219_0_3_1"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="274"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="527" mass="58652" checksum="75E4ECD963AC9E85" modified="2012-03-21" version="1">MSKSECIWKWLGATTDDNLIDPNTNPASADVVFVPALVPSNRDHDPKHPRRGLKRPASKETIAVPDLDFSISHNTRKESNRTILTPPVSTTDRDLPPLRPAVVMSQEGTPRKRPRPLPDSDHTPRASSSVSNPPLAPQDSVSRTGSTSATGSSASGRSSRSPTKLLNALELKEPLQIEFKFFSDADVSESIHLPPALAEVRDTIYDFYKDRRIIPLSHKVRCPHPVPSITCHIGRDNSPILPLPSLTLCLLFLPTQTEAATIRGPEARDISSLTLFEDTSEPQRYGPIPPVRSLRAAVRNSSKFASQRASEPMWNTEVHAHLLRLALRPDLEDVDNGLVNFTVATTARTHHLLHNGGPSKMIDFAMYIDTEVVQDMHLSQRIKELRQKFPSNAVNSTPYHFLRNKPISVTIETKRSDGLEQAVLQIGIWQAAHWAYLDRIASKKGATLDGLEFLPGLVVSGADWYFVASTREGQRTACPPSPTLWEKQPIGSTQSLVGTYKVIRTIQYLAWWSAEVYWPWFMSTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1C1</accession>
    <name>H1V1C1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_06101</name>
        <name evidence="14" type="ORF">CH63R_05788</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000981">
        <property type="protein sequence ID" value="CCF34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158613.1">
        <property type="nucleotide sequence ID" value="XM_018300763.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759273.H1V1C1"/>
    <dbReference type="GeneID" id="28864870"/>
    <dbReference type="KEGG" id="chig:CH63R_05788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05788"/>
    <dbReference type="eggNOG" id="KOG4097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096618_0_1_1"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1F8</accession>
    <name>H1V1F8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH063_06135</name>
        <name evidence="23" type="ORF">CH63R_10771</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="25">IMI 349063</strain>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="154" mass="16276" checksum="1F0459C0231E9514" modified="2012-03-21" version="1">MCGPDTCTKPRGGALAVLNQPFSQPEATGTSPRLRGDLAFHTPGQPSCAYATHARITGGNNCDLQALADMVVVIHKSGDLTRRIEDCGLFRRIAFSGASVLENGSTVELALQQPISLQVGDDGIIGRRVSVFPRSEMDTACAEGIVGFNFVNSL</sequence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="21"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF34448.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="505" mass="57555" checksum="A2FEFDB565DC010A" modified="2012-03-21" version="1">MGNRSSSSAKRRARAAPKKPVKPQFPVVKMEPRTFSSLPNEVIVLIAKESIAEGGHRHLRSFCQTNRRNFELSQRELYRYMVIHHELQLLFLARSLIENPSLRGMIRTFIARANQWHCRQRDSDPSIRDWHNISVDESKLSQLDRQLLILSRAHCTQKSVDNIQCVFGLLLFFISQVEHVTIEVDWYWPVLDSFLAAGLASSTPLPADDSMDVNLYSALLPNLKTLSLATKLYLRKELRLIQARPFHPFNALTASTNLRVFVFDGDMDKWGDLDEIESPMKLTFSTVKLTASHFSSSSLCKFLRHCPDLQRLEVAPQGYAADYGKEENINSVLPKYCPQLRELSLRLGGTSRSFFRSEQRTLSCLPQLVHLKELRIEVNSFLIRNTHLNTLILPNKLPEQLEKLFLDASMALVPFPALGGRMTASTPEARTYKRAVDSMIQDLCRAREDQLLQLNTIVVGAKYVKPVLWTKNANKTLAGTGARLRVTSGVEIHKLWDSSWDAMKI</sequence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001276">
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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        </source>
    </evidence>
    <sequence length="688" mass="76438" checksum="E35A34FFFB4C7740" modified="2012-03-21" version="1">MLQGWFNADRLVSFAHVQGPLRFEPIMRADVVKTLRDAAAASGEESNISYMLARPNTTLTVRERLGLGDASNPSTSLKITVETIPKDLKKAFRQYEGKPAILVFDVHEEWDAAFCAAMIDLSCLCERWASARQHRLHVVWLSSAPWDPLFSRIMSIHGDRGGVSTMRMRLPAARESVDRLRWAVYGSPFSEEGQLTKLARRIVEDHAALPADDADRHTTVLVVGPHAEKLRSAIRLASNDTVETENITVAVIPRHLAHVMSQDKTFPPVRHLVLGDTHLDDTWSPCFSQVVVSVIKVPSMAAIRDQVAMAYADGVDPAQVTVHAPVSRDKLHQAEHARKFEDIHMASIIALAFSKLPHTNLDRLKRILSTDNHRWETAVHRLQLAGFVQPSDFHPGGFAVAPVERAARTAMWLPHVDYDFSIAHFLAANTGQTSTEAFDAILDIGAILVAANRRGQVLVEYDRKRHPVKMRMGIKPAAIAKDIDNECYGIPPGVSATGSLWITLGLYRRTKLEYDRGTIVPGSHSWTPATKWVTIDLAVASDALATRMGFKEICVDTATASLSDRRGTREMTQGDVDFVRTTMLECWIHRLIYADYKETFSDGLPHMFAPWTCGVYVHTLSLATGFFAGESYSAEPSGEAFIIGTSSAGFQRGTALTNPTWIPAWIVKTWMADRGLQLEHLRPPQCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V433</accession>
    <name>H1V433_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_06859</name>
        <name evidence="5" type="ORF">CH63R_11875</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001350">
        <property type="protein sequence ID" value="CCF34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153690.1">
        <property type="nucleotide sequence ID" value="XM_018306849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V433"/>
    <dbReference type="STRING" id="759273.H1V433"/>
    <dbReference type="GeneID" id="28870956"/>
    <dbReference type="KEGG" id="chig:CH63R_11875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11875"/>
    <dbReference type="eggNOG" id="ENOG502SCTZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122140_0_1_1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="119" mass="13596" checksum="835DA2EB90B78163" modified="2012-03-21" version="1">MSIPNQALEKLIREIESQAIVAQQQIGQARTQMTAKQREMRMVHLTLDEVSTVSPNSGVYEGVGKMFVSIPTPQLKEKLEGQIKEREGEVEKLSQKLHYLETTYKNSRQHIDQMLKAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>H1V480</accession>
    <name>H1V480_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_06894</name>
        <name evidence="2" type="ORF">CH63R_14420</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001370">
        <property type="protein sequence ID" value="CCF35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150637.1">
        <property type="nucleotide sequence ID" value="XM_018309394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V480"/>
    <dbReference type="GeneID" id="28873501"/>
    <dbReference type="KEGG" id="chig:CH63R_14420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14420"/>
    <dbReference type="HOGENOM" id="CLU_2775797_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="8261" checksum="CA883AB4A2CDCADB" modified="2012-03-21" version="1">MRAALTSPYQSVNQAQEVAFRLEQVVSLNVQRMVARQRTFETVIRPVFQMMRFFLVEHDSYVHIFRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4G5</accession>
    <name>H1V4G5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_06965</name>
        <name evidence="10" type="ORF">CH63R_01116</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001406">
        <property type="protein sequence ID" value="CCF35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164453.1">
        <property type="nucleotide sequence ID" value="XM_018296091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4G5"/>
    <dbReference type="STRING" id="759273.H1V4G5"/>
    <dbReference type="GeneID" id="28860198"/>
    <dbReference type="KEGG" id="chig:CH63R_01116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01116"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000369">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="208" mass="23593" checksum="68510440953ADB45" modified="2012-03-21" version="1">MAAAQTPTFKLVLTTFVKRHLTGEFEKKYMATLGVEVHPLGFTTNFGQIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPALEFVAAPALAPPTAQVDEKLLEQYRQEMAAAAEMPLPGELSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5I3</accession>
    <name>H1V5I3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_01322</name>
        <name evidence="13" type="ORF">CH63R_00475</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15295.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_018163812.1">
        <property type="nucleotide sequence ID" value="XM_018295450.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V5I3"/>
    <dbReference type="STRING" id="759273.H1V5I3"/>
    <dbReference type="GeneID" id="28859557"/>
    <dbReference type="KEGG" id="chig:CH63R_00475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00475"/>
    <dbReference type="eggNOG" id="KOG3174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045864_1_0_1"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
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    </dbReference>
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        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mating projection actin fusion focus assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
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    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
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    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
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        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="283" mass="30928" checksum="AE7AAAE62C69C25E" modified="2012-03-21" version="1">MTSVDPFDSALDLLRRLNPKHTTDHLNAIISLAPDLTEDLLSSVDQPLTVKRCKQTGRDYLLCDYNRDGDSYRSPWSNQFDPPLDEAGAGGVGAGGSEGAGEGAIPSERVRKMEVRANEAFDVYRDLYYEGGVSSVYFWNLDDGFAGVVLLKKSATPGGSAEGIWDSIHVFEAIERGRTTQYKLTSTVILSLSTSTGALGDMDLSGNMTRQVEQELPVEGDESHIANVGRLVEDMELKMRNLLQEVYFGKAKDVVGDLRSVGSLSEGARDRAAQREIIGSMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6P7</accession>
    <name>H1V6P7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01391</name>
        <name evidence="4" type="ORF">CH63R_10190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
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        <property type="protein sequence ID" value="CCF35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018305164.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V6P7"/>
    <dbReference type="STRING" id="759273.H1V6P7"/>
    <dbReference type="GeneID" id="28869271"/>
    <dbReference type="KEGG" id="chig:CH63R_10190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10190"/>
    <dbReference type="eggNOG" id="ENOG502S4ZA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064527_1_0_1"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="213"/>
            <end position="236"/>
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            <begin position="353"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF35899.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR06070.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
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        <name evidence="8" type="ORF">CH63R_10188</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001746">
        <property type="protein sequence ID" value="CCF35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154586.1">
        <property type="nucleotide sequence ID" value="XM_018305162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6P9"/>
    <dbReference type="STRING" id="759273.H1V6P9"/>
    <dbReference type="GeneID" id="28869269"/>
    <dbReference type="KEGG" id="chig:CH63R_10188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10188"/>
    <dbReference type="eggNOG" id="KOG1763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042870_1_0_1"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="ZC3H15/TMA46_C"/>
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    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
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            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
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            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
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            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
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            <begin position="333"/>
            <end position="355"/>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50103"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF35901.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR06068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="39971" checksum="91E12419CA4A2550" modified="2012-03-21" version="1">MPPKKNDKGAAKKPAAGKALEDKTFGMKNKKGGAAQKQIAQLHSSMKNGGSAEQKRKEAEKAQREREKKAAEDAKRETELLLNKPAQIQKVPFGVDPKTVVCIFFKKGNCEKGKKCKFSHNLEDERKTVKKNLYTDTRKEEEEKKKAETSADWDEEKLRSVVLSKKGNQQTTTDKVCKFFVEAIEDGKYGWFWVCPNGGDKCKYKHALPPGFILKTKEQRAAEKALLDKSPLKTLTLEDFLESERHKLTGTLTPVTPESFAKWKKERLDKKAAEEQAKKAKEATGRALFESGNWRTTEDDEEEEDDDDGVWNLEKLRAETEALRIRREEERLLAINGGTLPPAETNTAVAEASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7T7</accession>
    <name>H1V7T7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_01468</name>
        <name evidence="14" type="ORF">CH63R_05771</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family. ARP4 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5132116at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="Actin-like ATPase domain"/>
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        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCF36289.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OBR10079.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="474" mass="52629" checksum="5CEC9020986A5C51" modified="2012-03-21" version="1">MSQQPLSSSVQPTDIYGGDEVSALVLDPGYCTTRAGFAGEDVPKSVFPSFYGRVGSSDTPTTVFGDECLIPRADLEVHNYMSRDSVVEDWDVANKLWEHMLITRLQPARPTPPSKNGLNDDPKEEVEGAANGDVDVAMEDVETQEKALQENPLLMTEAPWNNAKSREKAIEIIMENWGCPAFWLSRTPVLAAFAAGKASALVIDVGGSNTSVTAIHDGMVLKRSIQKSPVGGLWLSSQIRSLWETSEPKIEPIPTFMVENKTPVDAGAPPQFKQRQFGFSITDSFRTYEDERLITEFKESVVETWRGPGKYAVPQNEEFAKTQPGRVFEFPNGANQMWREQRYKVSEGMWDETAAFPTNNEEFRLNKSQTIPELIRAALNAVDVDLRPNLLGNIVVTGSTSLLNGFNDRLNNELTAMYPGLKIKIHAAGLSSERRFGAWIGGSILASLGTFHQMWISRKEYEENGVSIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7W1</accession>
    <name>H1V7W1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp90-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01471</name>
        <name evidence="7" type="ORF">CH63R_05677</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1055"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="117"/>
        </location>
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            <end position="116"/>
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            <end position="157"/>
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            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V838</accession>
    <name>H1V838_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">H+ symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07971</name>
        <name evidence="9" type="ORF">CH63R_05128</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001958">
        <property type="protein sequence ID" value="CCF36390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161349.1">
        <property type="nucleotide sequence ID" value="XM_018300103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V838"/>
    <dbReference type="STRING" id="759273.H1V838"/>
    <dbReference type="GeneID" id="28864210"/>
    <dbReference type="KEGG" id="chig:CH63R_05128"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05128"/>
    <dbReference type="eggNOG" id="ENOG502QPK1">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001265_46_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:plasma membrane lactate transport"/>
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        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sugar transporter family protein"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
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    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
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            <begin position="492"/>
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        <location>
            <begin position="500"/>
            <end position="530"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF36390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="530" mass="58576" checksum="0CAF038714014095" modified="2012-03-21" version="1">MDSPRDKTHIDPEQSPRAEHHGDQEPWHGMSAGQYLGTRFTTLKPPMLSAPNPLKLVVMINRRQWAFFAVAFAAWTWDAFDFFTVSLTITELSETFNKSKTDITWGITLVLMFRSVGSVIFGIAADRYGRKWPFVVNNLLFIALELGTGFCQTYDQFLACRALFGIAMGGLYGNAAATALEDLPSETRGMMSGVLQQGYAFGYLLAAAFARGLVNTTPHGWRPLFWFGAGPPVLFILFRLMLPETDTFNEHKRIREAAGRQAAAAAGGSVTSTFLKEGKVAVRKHWLLLAYLVLLMAGFNFMSHGSQDLYPTMLTNQFSFDADQVTVTQVVANLGAMLGGTTVGYCSQIFGRRFSILVCCVVGGALLYPYTFVTTEAVMAAAFFEQFCVQGAWGVIPIHLMELSPGAFRTFVVGTSYQLGNLVSSASSTIEARLGEQFPLPPRGGTKRFDYGRVICIFMGCVFAYVILLTFVGPEHLRRSFDVADDSDMREVAGDETMEDELHHREARVGHGVHSDEETGHQEKSATHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGD0</accession>
    <name>H1VGD0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_10154</name>
        <name evidence="11" type="ORF">CH63R_02547</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02003410">
        <property type="protein sequence ID" value="CCF39283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162338.1">
        <property type="nucleotide sequence ID" value="XM_018297522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGD0"/>
    <dbReference type="STRING" id="759273.H1VGD0"/>
    <dbReference type="GeneID" id="28861629"/>
    <dbReference type="KEGG" id="chig:CH63R_02547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02547"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_2_1_1"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF39283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="46916" checksum="324CCB034243D6F8" modified="2012-03-21" version="1">MSVEVTPSKQAAAALDSFKMESPIKKLNFNAADKENQPLASDVATATENTDKQTKPTQEVAKQQTKPAVAPSIKEQELDEPLLQENGQRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDLHDWNNKINEDEKYFISHILAFFAASDGIVNENLVERFSGEVQVPEARCFYGFQIMMENIHSETYSLLIDTYIKEPAQRTYLFNAIDTIPCIRKKADWALKWINDEKSSFAQRLVAFAAVEGIFFSGAFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYSHLKNRPSKQVIEDIIVDAVKIEQEFLTEALPCALLGMNSNLMKQYIEFVADRLLVALGNDKVYKSSNPFDFMENISLGGKTNFFEKRVADYQKAGVMNSTKKAQEEPTEGKGENGGDFVFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGN9</accession>
    <name>H1VGN9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02117</name>
        <name evidence="3" type="ORF">CH63R_11729</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003468">
        <property type="protein sequence ID" value="CCF39392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153544.1">
        <property type="nucleotide sequence ID" value="XM_018306703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGN9"/>
    <dbReference type="STRING" id="759273.H1VGN9"/>
    <dbReference type="GeneID" id="28870810"/>
    <dbReference type="KEGG" id="chig:CH63R_11729"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11729"/>
    <dbReference type="eggNOG" id="ENOG502SV0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1337425_0_0_1"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497671" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="205" mass="21894" checksum="76BB04C29FEA13E4" modified="2012-03-21" version="1">MVHLLSFLALGFAGAAIASPLASIQQCQDAALTLTSLEYSGEGCPEGSLQGTLGIDGDFDVFYKNLTASIKPKEPKVNIRCQIKVGLQTSASKQLVIVSGAYKGHVRLTEGAWAKNQNQYKFANNPGTIDMEWPFKGPVDVATVFSNKLNIEFQSGCNSNGGQLTLIINNYLTMTTEGTGEGEISVQELDGAIEQSIKLATKDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJN5</accession>
    <name>H1VJN5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH063_11001</name>
        <name evidence="20" type="ORF">CH63R_08043</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="CACQ02004085">
        <property type="protein sequence ID" value="CCF40438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157795.1">
        <property type="nucleotide sequence ID" value="XM_018303017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJN5"/>
    <dbReference type="SMR" id="H1VJN5"/>
    <dbReference type="STRING" id="759273.H1VJN5"/>
    <dbReference type="GeneID" id="28867124"/>
    <dbReference type="KEGG" id="chig:CH63R_08043"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08043"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_4_2_1"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="340"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCF40438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR09278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="704" mass="80327" checksum="2843DAF22A18DCAF" modified="2012-03-21" version="1">MAPGESSRPSSHRPRDSSGRKHHKKRRSNAQGSRRPATESGESRDERRSQTLSADALAALNHENTKRRKRRESRDPERDAERAAERAERRRARREQQYRDAPRERPRRAEREEDREAVYEKPRRDHKSRKRRVVSGAVMEEGRSRGHLRGGGWSSSNNSLEKEYLMDDPPQPVKKRKKLWICLGISLVLLIIIIVVAVVVSKNNSNKSSPSKTTLDDGDKDSVPMKWRGTYLDPWSWQDTTDFNVTFTEEMVGDLPVMGLYTDWDDSKRANDKVPALKDSWGSYGSRPARGVNVGGWLNLEPFITPSLFDYDSRLGIIDEYTLCNHLGTRKTAEVLEKHYATFVTESTFKEIADAGLDHVRIPFNYWAIEVYDGDPYLFRTSWRYLLRGIEWARKYGLRVNLDVHGLPGSQNGWNHSGRQGSIGWLNGTDGATNAQRSLDMHDRLSKFFAQDRYKNIIAFYGLANEPRNVDLNNADVVAWTEKAYKLVKNNGIGGIVVFGDGFMGLHNWQGKLTGYSDLALDVHQYVIFNTDQIVYTHKKKVEYACSGWTEQTEQSIDTSTGYGPTLFAEWSQADTDCAKHLTNVGWGNRWTGTYNTGNATTSILEPRCPTEDSKCDCDAANGDAKGFSSDYKKFLQMFAEAQMHSFEKGWGWWYWTWDTESAPLWSYKKGLEAGILPAKAYDRDFDCSGTVPDFSSLPEFYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJP4</accession>
    <name>H1VJP4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_02357</name>
        <name evidence="13" type="ORF">CH63R_00439</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CACQ02004090">
        <property type="protein sequence ID" value="CCF40447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163776.1">
        <property type="nucleotide sequence ID" value="XM_018295414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJP4"/>
    <dbReference type="STRING" id="759273.H1VJP4"/>
    <dbReference type="GeneID" id="28859521"/>
    <dbReference type="KEGG" id="chig:CH63R_00439"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00439"/>
    <dbReference type="eggNOG" id="KOG2575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008110_2_1_1"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF40447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="600" mass="67402" checksum="F9B3DC0D5E8D1A3B" modified="2012-03-21" version="1">MNSSSPHKPRRRGKKTTSSGNAASSSVGNPSIESQILKKEALVKVPVFPLASFLWPARGSVSQWEVLPLILMVVGLFRWAAGLWGYSGFQNPPMFGDYEAQRHWMEITTQIPVSQWYFHDLQWWGLDYPPLTAYHSWLCGKVGALIDPTWFELYTSRGSDDPSLKIFMRATVIVSEYLIYIPAAVIFVRRFSRSSNVPTWTAWMALVAILMQPATILIDHVHFQYNTVMLGFVLASMSSMLAGRYLWSAVFFVAALGFKQMALYYAFSVFSFLLGSCVFPLRPGRFIGIALATVAAFALLILPLVLGTLYDAHRGIDARPDYEGPPPTLPLFPWLTDLLDTNAIYYPVVEQLIQMVHRIFPFARGLFEDKVANFWCALNVVIKLRQYPTDLLQRGALAATLASIIPPNLILFFRPRKLLLPLAFATTAWGFFLFSYQVHEKSALLPLMPMTLLLAGKQGLSRDVRAWVGFANILGAWTMFPLLKRVDLGVPYVVLTLLWAYLLGLPPTSLSAYFQEDQGWMRQWATFLLHGAFYVMMTAWHVAERVVVPPANKPDLWVVANVGIGAVGFGICYLWCLAQLVAQSDILPTRGNSKNKAKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJU2</accession>
    <name>H1VJU2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_11046</name>
        <name evidence="9" type="ORF">CH63R_14108</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004116">
        <property type="protein sequence ID" value="CCF40495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151400.1">
        <property type="nucleotide sequence ID" value="XM_018309082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJU2"/>
    <dbReference type="STRING" id="759273.H1VJU2"/>
    <dbReference type="GeneID" id="28873189"/>
    <dbReference type="KEGG" id="chig:CH63R_14108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14108"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_1_1_1"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="15812" checksum="DFE1EC2E9FE34157" modified="2012-03-21" version="1">MATDPTSPGIPRSGSASPAPATIPDRSASPEIPLTMSASAILTAQPPDVASALASAGEYPSDKVVVKFKAVGNAPLLARGVAKISSTQTFHTVIWYLRKRLKLQESDSVFCYVNDSFAPSLDEILGNLHNCFRDSSGQLVISYAMNPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK36</accession>
    <name>H1VK36_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_11116</name>
        <name evidence="11" type="ORF">CH63R_10096</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004172">
        <property type="protein sequence ID" value="CCF40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154494.1">
        <property type="nucleotide sequence ID" value="XM_018305070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VK36"/>
    <dbReference type="STRING" id="759273.H1VK36"/>
    <dbReference type="GeneID" id="28869177"/>
    <dbReference type="KEGG" id="chig:CH63R_10096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10096"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="195" mass="21979" checksum="4DFD083B548B5A91" modified="2012-03-21" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKKDLRYDSKTIEELRKTSQKPVSPEEGEEVRKKIGAYKYLECSAKTNEGVREVFEHATRAALLSRSRSSGKKHKCMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL12</accession>
    <name>H1VL12_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11354</name>
        <name evidence="3" type="ORF">CH63R_11955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004380">
        <property type="protein sequence ID" value="CCF40915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153770.1">
        <property type="nucleotide sequence ID" value="XM_018306929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL12"/>
    <dbReference type="GeneID" id="28871036"/>
    <dbReference type="KEGG" id="chig:CH63R_11955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11955"/>
    <dbReference type="HOGENOM" id="CLU_2183772_0_0_1"/>
    <dbReference type="OrthoDB" id="4764690at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497693" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="109" mass="11779" checksum="E706059201DBC829" modified="2012-03-21" version="1">MKPIQTAMLVLATMTGVQSAPAADANIVIPDSSMRSEYHTSWVEDSTRPWLRKRARGKGDPCDPGRGQCVTGLGCYGCSNHQPVCQRGPGSNECCHRDNLSSVVICDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VMK2</accession>
    <name>H1VMK2_COLHI</name>
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        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_11723</name>
        <name evidence="10" type="ORF">CH63R_07343</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004703">
        <property type="protein sequence ID" value="CCF41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157096.1">
        <property type="nucleotide sequence ID" value="XM_018302318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VMK2"/>
    <dbReference type="STRING" id="759273.H1VMK2"/>
    <dbReference type="GeneID" id="28866425"/>
    <dbReference type="KEGG" id="chig:CH63R_07343"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07343"/>
    <dbReference type="eggNOG" id="KOG2889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039466_0_1_1"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="276" mass="31753" checksum="86612582744A680A" modified="2012-03-21" version="1">MSKPDLVYADERRFLDERGSSASLAPNGENPATIMEKAVRERIVDSYFYKEQCFAVNEADIVDRVVEHVTFVGGTYGVTQKPTPFLCLAFKLLQLAPSDDVLEAYLGLGGEKFKYLRALACFYVRMTRKARDVYLLLEPFLEDRRKLRRKGRQGTSLTYMDDFVDDLLTKTRVCATSFRELPKRSDLVDLDELEERISPLGDIDELLEEEDEREAKEREEADARENGADESDGEIVEDRSGDSEPMDVERRHSRSRSGPRSQSRSRSRSRSRQRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VN18</accession>
    <name>H1VN18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02632</name>
        <name evidence="3" type="ORF">CH63R_11503</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004813">
        <property type="protein sequence ID" value="CCF41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR04800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153318.1">
        <property type="nucleotide sequence ID" value="XM_018306477.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VN18"/>
    <dbReference type="GeneID" id="28870584"/>
    <dbReference type="KEGG" id="chig:CH63R_11503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11503"/>
    <dbReference type="eggNOG" id="ENOG502SCK8">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_038838_1_0_1"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="502" mass="57286" checksum="15B4B5AE98FD2F12" modified="2012-03-21" version="1">MPFLDEITLSRDHEKLYSPGQTLSLTPHKAPKPWGWKYYRMPPDLKDEATAQGEEDRELTRLAMVFQEGNQPHRLDRQVQKDESKKMKVEILELFGIDRFGEYTPGTQKLKCKVLQVPSNSNDDHQHPAVDDIIFIKAFDPMFFPRNVSAIDMEWKVTARADMALSNEVGAYGFLYKHGLTGSPHVAPQWFGCWTAEAQTTDLEYEGRTRHVGVIALEYIDGICLQKLLRTNEDGEYYYIGDRLRIDNDVRALVQLDQATRFGVIEDLLADVVVQYKAGVNHPCIYPENIVLSFRRGSEELKRPRVSLVGYKDSIVNPLRQPPRNSFADYPKPIHPFFRFSYKRLRLFFLCHWFPSDWQPDENERCRPLDRWLMSTFGPFADNEKYNDRIERNPVIAARAAVLVAARRLREKTAAIKPTEAEETGIAESHEDSQKTREPVIEPNPTASQIEETSSPNVTSYNMPVGEEKAIVSESTDTGATEAAESHEEAQKAGGSGHEDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQ72</accession>
    <name>H1VQ72_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_02812</name>
        <name evidence="4" type="ORF">CH63R_00914</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005345">
        <property type="protein sequence ID" value="CCF42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164251.1">
        <property type="nucleotide sequence ID" value="XM_018295889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VQ72"/>
    <dbReference type="STRING" id="759273.H1VQ72"/>
    <dbReference type="GeneID" id="28859996"/>
    <dbReference type="KEGG" id="chig:CH63R_00914"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00914"/>
    <dbReference type="eggNOG" id="ENOG502R3Q4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048788_0_0_1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="325" mass="37247" checksum="FFF721C4974E057E" modified="2012-03-21" version="1">MSKKRTLDAFFTPSVKKSRHDEPGEVVRRSNHASYPIAISELPSSISKELSSLPARPGRDVNDQPDLDLVYFEPYVPSYLAKDLFEFLRAELPFYRVEYDINRGGYQTHIRTPRYTTVFGLDETARFDEDGSVVDVRSGFKVDDRRYERYPPRPIPKCLDDLRRSTEAATDCRFNFCLVNYYASGNDSISFHSDDEKFLGPDPTIASFSLGARRDFLMKHKPIPPDDQNPHGPQPKQLKLPLASGDMILMRGRTQSNWLHSIPKRTGKNAEDGGRINITFRKAMVKDGTENYYNYNVGTGPVYRWDKTMREMRVSSAKDQLEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQT9</accession>
    <name>H1VQT9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_02872</name>
        <name evidence="8" type="ORF">CH63R_12197</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR05494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VQT9"/>
    <dbReference type="GeneID" id="28871278"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12197"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="64353at2759"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta_Casp"/>
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        <property type="entry name" value="Cpsf2_C"/>
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        <property type="entry name" value="CPSF2_MBL"/>
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        <property type="entry name" value="Metallo-B-lactamas"/>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="287"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <end position="650"/>
        </location>
    </feature>
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            <begin position="853"/>
            <end position="867"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF42595.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRA0</accession>
    <name>H1VRA0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV damage endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_02917</name>
        <name evidence="9" type="ORF">CH63R_03605</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
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        <property type="protein sequence ID" value="CCF42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018298580.1"/>
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    <dbReference type="GeneID" id="28862687"/>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
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    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="663" mass="74367" checksum="EB9D4F2A8333161A" modified="2012-03-21" version="1">MAPSKRKKSAAAANAATAAAMDSLPGNLKSANPGPRRSARHLPEVNPVPVPESGATMCPAPGQEATDEPSAKRRHVSRNKVEAFQEGVRNAVIELSEMENRLQNATRTSRLAVEASSIALRSDAGRSEETNFRPRLKTRPTDPEDRARKDEEERSGTPNMDAAPINGPDGEAAICDVEDDKIREEDAPERGAAREPPVNSAYLPLPWNGRLGYACLNTYLRAANPPVFCSRTCRIASILQHRHPLADPNQPEHATKNRPDDTQPADIRRGQEYVQELGLANARDIPKMLRWNDKYGIKFMRLSSEMFPFASHEEYGYSLAPFAADALAEAGRVAAQLGHRLTTHPGQFTQLGSPRKEVINAAVRDLEYHDELLTLLRLPEQQDRDAVMILHMGGTYGDKPATLDRFRTNYAKLSPSVKRRLVLENDDVSWSVHDLLPICEELDIPLVLDFHHHNIVFDSSQLREGTEDITKLFDRIRATWTRKGIRQKMHYSESCPGAVSPRDRRKHSPRVRTLPPCPPDMDLMIEAKDKEQAVFELMRAFKLPGWDTFNDVVPYERLDELRANKAGNAKKDIKKPPKKSKKRAKNDDYDDEDDDNKGDGDGENKAAEPGPMDVEVSTISPDEFGMGGPQNRVYWPQGMEEWLKPKKREVKRSKSTKVKEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VS18</accession>
    <name>H1VS18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_02974</name>
        <name evidence="16" type="ORF">CH63R_12165</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005802">
        <property type="protein sequence ID" value="CCF43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153980.1">
        <property type="nucleotide sequence ID" value="XM_018307139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VS18"/>
    <dbReference type="STRING" id="759273.H1VS18"/>
    <dbReference type="GeneID" id="28871246"/>
    <dbReference type="KEGG" id="chig:CH63R_12165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12165"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="387"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR05462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="592" mass="63221" checksum="393C0C65487831BE" modified="2012-03-21" version="1">MSDRHIFTSSEGLVDKSLRGFISYNPSLALDQSNRVVFDTTYDRSKISIVSGGGSGHEPAWAGYVGNNMLAASVSGDIFASPSAKQILAAIERVPSDVGTILVITNYTGDCLHFGLAAEKARSRGHNCRMIICGDDVSVGKKGGSLVGRRGLAGQVGVLKVISGASGAGAGSLDDIHKLGVAVESEIVSIAATMDHCHVPGRSEHARLNADEVEVGTGPHNEPGYKKVSPSPSPEALVDQLLRYCLDQNDPDRSYVKFSPNDETILLVSNFGGISYLEMGALVDELLEQLDEKWNIRPSRVYSGPLETSLNAPAFSVSLMNITTASEKCSFSAEQILSFADVKTNTHWESMAGSQTVRRDRKLQFVTSPPEEPKKIEASRDVRMDPATLKSMLRMACLAVIDAEPDLTKWDMVMGDGDCGETLKTGASHLLDALENRGIASEGSIVSVLHELEEIVESKMGGTLGGILGIFFVSLSNSVQEHAHLARSQGILSLWTLALTSGLEQLGHYTPAKVGDRTILDVLIPFVSAIRDGGFEQAVEAAVQGAEYTRKTKAKLGRATYVAVSEKDTTFHPDPGAWGAMVAIKGLQSGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSR1</accession>
    <name>H1VSR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylic ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_13025</name>
        <name evidence="2" type="ORF">CH63R_09834</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005970">
        <property type="protein sequence ID" value="CCF43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154232.1">
        <property type="nucleotide sequence ID" value="XM_018304808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSR1"/>
    <dbReference type="STRING" id="759273.H1VSR1"/>
    <dbReference type="GeneID" id="28868915"/>
    <dbReference type="KEGG" id="chig:CH63R_09834"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09834"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076139_1_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="195" mass="21654" checksum="146C13E0AEFA8D85" modified="2012-03-21" version="1">MANSSTAKEEGDWAIVSFKDPWHFPTCNGISPFSQGISRPSYDPALDRWCLLAEVTDTAFFFSARVIARDRDGKDFVVGFYPNNADAANLNLGQFHVGHTIALAYPKPHKFPDGLWGVRVDELDSCSLFPVGLNDLLRINSDLCAYIGPRGTPRKCQACGKHDKELITCGVCQLYSYCNPVWRLCVLSTETVLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTN0</accession>
    <name>H1VTN0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_03111</name>
        <name evidence="7" type="ORF">CH63R_00401</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006212">
        <property type="protein sequence ID" value="CCF43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163738.1">
        <property type="nucleotide sequence ID" value="XM_018295376.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VTN0"/>
    <dbReference type="STRING" id="759273.H1VTN0"/>
    <dbReference type="GeneID" id="28859483"/>
    <dbReference type="KEGG" id="chig:CH63R_00401"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00401"/>
    <dbReference type="eggNOG" id="KOG0908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_0_0_1"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="130"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="322" mass="35270" checksum="CCE22C98FA945268" modified="2012-03-21" version="1">MSTVHIKSPTEFQTLLSSSRIVVADFYADWCGPCKAIAPLYEQLSSSLSRKNAVTFVKIDIEAHKEIAAAYNVTSLPTFMIFREGKTIEKVQGADPRKLQEVVKKLAKEVSETGSSSGEASGNSSGGSWRGAGLPRGYGDITDQVEARGCELLNADEDFGPVRVLFDTSKPSALTKKEGVKDWVESGADDQLLLFMPFQSMLKLHTLQLTSLPPADDDEAPMRPGTIHLYTNKPHNLDFSEADDTPPTQAIELTEKDWNADGTANIGLRFVKFQNINSLIIYVTKGDGDGEKVRLDRVRLIGESGEKREMGKLEKIGDEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVD5</accession>
    <name>H1VVD5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03269</name>
        <name evidence="3" type="ORF">CH63R_13366</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006690">
        <property type="protein sequence ID" value="CCF44195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152757.1">
        <property type="nucleotide sequence ID" value="XM_018308340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVD5"/>
    <dbReference type="STRING" id="759273.H1VVD5"/>
    <dbReference type="GeneID" id="28872447"/>
    <dbReference type="KEGG" id="chig:CH63R_13366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13366"/>
    <dbReference type="eggNOG" id="ENOG502QRQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030046_1_0_1"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF44195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="458" mass="50982" checksum="757898489FC6E03B" modified="2012-03-21" version="1">MYQKQKVGYSLAQRNHRWRQRGPPLGLLVEKVDVAELAKPAKRYRSSAQVTNCELVASYNWLDKKQPTVMIPGAPPRWTPLAEPQELKEDDGVYYRDKNAARYPAHPMEPGARAVLMMHPEPLTKPVDVVACGSTIGSLLRFVRGNERPFRMLVEVVGGVVHLIRRENSPTETIPNVKGFGRTFPETYTTWDASVRQSTSHQRVLRYDFAGLGCIVRHEGDGYFEDRLGLSSNRAPSSDDEKDSIDALAKDLDASGITSKTHIHSSKLHLLSGGFPVPQTAVFDLKTRSMLRRDKDFLGEELPRLWVAQIPNFILAYHERGSFTEIDVMDVSDKVKTWEASMNRELSQLAALLHRIVGLARASQDGKLEVSRQALTTLEVRKQCAGVSPVFSADMMAKWKAWLAADAASEAGNDEDSNSEGDSNDNDDSDDGNLAWGEGDGDYTACSEKCSYCGRCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVK6</accession>
    <name>H1VVK6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_13722</name>
        <name evidence="2" type="ORF">CH63R_08947</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006761">
        <property type="protein sequence ID" value="CCF44266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155944.1">
        <property type="nucleotide sequence ID" value="XM_018303921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVK6"/>
    <dbReference type="GeneID" id="28868028"/>
    <dbReference type="KEGG" id="chig:CH63R_08947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08947"/>
    <dbReference type="eggNOG" id="ENOG502SU9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145544_0_0_1"/>
    <dbReference type="OrthoDB" id="5302289at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF44266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15401" checksum="77479A108A408A71" modified="2012-03-21" version="1">MLSITPQGDHHSQSLYLPFRSLSSPSRPVDDLPFLSSLASSMGHSLHVGNTSATAVSIKDAASVAQALEIARESPDGASDPTVSSILESAISQIWSKVTAQPESYVMNRDEFAVFNYFQHRFTGNKIAMAARKRYWDNARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWL5</accession>
    <name>H1VWL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_13965</name>
        <name evidence="3" type="ORF">CH63R_02389</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007038">
        <property type="protein sequence ID" value="CCF44627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162180.1">
        <property type="nucleotide sequence ID" value="XM_018297364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VWL5"/>
    <dbReference type="GeneID" id="28861471"/>
    <dbReference type="KEGG" id="chig:CH63R_02389"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02389"/>
    <dbReference type="HOGENOM" id="CLU_2922521_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF44627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="61" mass="6761" checksum="D687DE8B84133BA4" modified="2012-03-21" version="1">MIFSSRRFAHHYSPQNRRRRTQAQTNGKTSSTQGWLDMASAANVVRGTTSPASPPCPVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VY32</accession>
    <name>H1VY32_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_14321</name>
        <name evidence="3" type="ORF">CH63R_10239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007472">
        <property type="protein sequence ID" value="CCF45144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154637.1">
        <property type="nucleotide sequence ID" value="XM_018305213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VY32"/>
    <dbReference type="GeneID" id="28869320"/>
    <dbReference type="KEGG" id="chig:CH63R_10239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10239"/>
    <dbReference type="eggNOG" id="ENOG502SW7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117724_0_0_1"/>
    <dbReference type="OrthoDB" id="5372011at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="201" mass="21009" checksum="7DA6DD2E28E281B3" modified="2012-03-21" version="1">MSAPYYTPQRPYFPSPQQSSSSSSTAPRPGASAPPSFTPAMRDRQARGKDPYSPHDSPSDSDLEFDAVDSPSRAGVGRLGHLGGSGQGRGHPHGGAMAGAAGGGGGSGVATAGGGGVGDGDSHEVRRRKLWAVAVLEDPEKLAMYACSRGDSIPGTRLHFTRMLCGFDEETLQLPDHRKASASSRRDPRRRSAGGERMGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQM1</accession>
    <name>A0A1B7XQM1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150577.1">
        <property type="nucleotide sequence ID" value="XM_018309605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQM1"/>
    <dbReference type="GeneID" id="28873712"/>
    <dbReference type="KEGG" id="chig:CH63R_14631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14631"/>
    <dbReference type="OrthoDB" id="10520822at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="256" mass="28839" checksum="D93F1D7EF506D870" modified="2016-11-02" version="1">MSNPLNFGDMSTDDLLQLLTYTNSTPPVETGKPSPRQDYLGYTSLPSYPTNSTVTLDYPSTTTQQPPNKTETWAGYAANPPPGYGQVPVDPAEKRQSRQDARLTKLEDKVDEIKEELAEMNQHLTEQEMNCSRCGCDSGDESDDATEDDLSENAANGDVEGGNDYETHELCNIYITITVSDFQEEQKSFTEDGGEIPLAYTNYNTDIARTCSAYVLAKLALDKGEKYYAQNQRQETYHEHRRKRRTSRRYSSSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR96</accession>
    <name>A0A1B7XR96_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Probable kinetochore protein nuf2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_13502</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150794.1">
        <property type="nucleotide sequence ID" value="XM_018308476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR96"/>
    <dbReference type="GeneID" id="28872583"/>
    <dbReference type="KEGG" id="chig:CH63R_13502"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13502"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.60:FF:000003">
        <property type="entry name" value="Probable kinetochore protein nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="18">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="166"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="351"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR02276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="461" mass="53630" checksum="37707728C5C4030E" modified="2016-11-02" version="1">MSYNPRMSIIPPTQTQSRTRKKEDEADAFMRLPDKEIVGCITDIGIPFTVADLQKPNPLQVQMIFEWFAELLLNATRDTVEPAMRAAAEDICGEYSDVVPPDTRNLMGFYVSLRGLLAECGVQDFSFNDLYKPSYDRLVKIFSYLINFVRFRESQTSVIDEHFNRAETTKSRIESLYSENQEMESRLVDMKRNRKAMEAQVREKTTRNEELKQRLLELRRNQERVAARLEDAKVKKTELTTALEEKTAQKLGMKQDCTKLRPYVMQSPSTLQATLTELSNTLNSEKAHIEALDRRSRALQTSADSFSVVSTDVASCIKVLDEIGVELAKEEEENLKNVKQRDALSERGNNVREVERTEALLQRQLLKWNERTEKLREQSSTKAQEAKEKMEELRAVHRKLTEERTDKGKDIERRRVRIEQTEKKMLDLKENIENEIHSAYDEFLKMDSHIKLYITEMEQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRR8</accession>
    <name>A0A1B7XRR8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150967.1">
        <property type="nucleotide sequence ID" value="XM_018308649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRR8"/>
    <dbReference type="GeneID" id="28872756"/>
    <dbReference type="KEGG" id="chig:CH63R_13675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13675"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="17210" checksum="CEE014B5B61F2875" modified="2016-11-02" version="1">MPSWYNTLVGGQFRSHPCVNDTLCSDAQIARYPPGGNIRPDIITIQNRDHPSTADLPESHNRIDEWYAYKTNPVHDPYYTVLASLEETYIDELTPPEPEHMAPLHPISWYSIYKDVARAFYTGMGHTNDSYYEEYFIKHVTGGLEWVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS83</accession>
    <name>A0A1B7XS83_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151139.1">
        <property type="nucleotide sequence ID" value="XM_018308821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS83"/>
    <dbReference type="GeneID" id="28872928"/>
    <dbReference type="KEGG" id="chig:CH63R_13847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13847"/>
    <dbReference type="OrthoDB" id="4847041at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="105" mass="12347" checksum="DEB79FE016CB4D7B" modified="2016-11-02" version="1">MRLPVFFTAALALLRRWEPKDTGSLSNDHLPLDRLPECWQKCFQSTNHAYPPDVNKVGIRDFCEDKMFHLRMWDMHWLSACSTSDCNDEDIDKGQTWFEDVCNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSC7</accession>
    <name>A0A1B7XSC7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151191.1">
        <property type="nucleotide sequence ID" value="XM_018308873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSC7"/>
    <dbReference type="GeneID" id="28872980"/>
    <dbReference type="KEGG" id="chig:CH63R_13899"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13899"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="235" mass="26374" checksum="19E4FA623BDB1761" modified="2016-11-02" version="1">MSESKVLVLGGTGPAGICLLRELVHREHETIVFARNPSKIPRDLLDNSRVEVLEGQMSDTATLSSALARTSVVVSLLGPDIRDRTIDPSLYADIYRSHLFPLMRQHRVKRILAMGTLTICRPEDHWTLMQTMVTTLMPLFNSAVYRNMLNIARLFDEEGQNFDWTIFRIAQIPGASDEASWRQDREGGIFTGWIGEKGWMSSIRRAGLARWLVNAVEGKAEAWVGKMPAVSSLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSK4</accession>
    <name>A0A1B7XSK4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151286.1">
        <property type="nucleotide sequence ID" value="XM_018308968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSK4"/>
    <dbReference type="GeneID" id="28873075"/>
    <dbReference type="KEGG" id="chig:CH63R_13994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13994"/>
    <dbReference type="OrthoDB" id="4847496at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="350" mass="39100" checksum="51304D14783BC37F" modified="2016-11-02" version="1">MSGPYPNQFPFSSDNSYQPPYVYEQGYNQNTSSYMYDQYHQPPHVPQPVAQPQYYQPGYSQARPYTVPDDNGDEYDGQRASKRLRSGYRYRDRRTSSIPAAPWDPNRSTTPEFEPPLQAHIFSPRSIPGGYSATLTASLSIPDTVDHEERLRRQSEIKHILQSTTSTALPAPSPRVKSPRPTSVSAPSPTSVYRIRARPKEIQVGPMLSPRYLGAFTRVDDVPAGPEREAAVEHNNRLAAARLAELKRRNNAAASRSRNRRERAVVGRTEALSAARAQMHWWKARAVSLGAAAGEWDALPERAVREALVADYRVDALDYSRDDPGEALAEAKPARKAGVAKRKRKASSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT27</accession>
    <name>A0A1B7XT27_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151431.1">
        <property type="nucleotide sequence ID" value="XM_018309113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT27"/>
    <dbReference type="GeneID" id="28873220"/>
    <dbReference type="KEGG" id="chig:CH63R_14139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14139"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="78" mass="8356" checksum="408B824E6F5E1500" modified="2016-11-02" version="1">MGLPIKLGVPHVPKEDSTQGQPTQTNDRQNQQQTEPATGAGANTGAGTTRSKTEAEIQADRLYEEAIEEEYAKRDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT94</accession>
    <name>A0A1B7XT94_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_14202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151494.1">
        <property type="nucleotide sequence ID" value="XM_018309176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT94"/>
    <dbReference type="GeneID" id="28873283"/>
    <dbReference type="KEGG" id="chig:CH63R_14202"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14202"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000040">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601041" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="71"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="416" mass="45249" checksum="E45FBD000DD4E081" modified="2016-11-02" version="1">MHFKSVVVSGLVAAAARQAGASPCPKPPPTYKPITSIQLGPRPYWLVNDMDEGPLKEKLQSCSEQPIKPSDWSIGHRGGGTMLIPEESIESNLAGARMGAGVLECDVAFTKDRELVCRHSQCDLHTTTNIVAIPELNAKCTTPFTPAGNGTAATAKCCTSDITVAEFKTLCSKMDGFNASATNPKDFLLGTPRYRTDLYATCGTVMTHKEHIAMTNDLGLKFSPELKLPEVEMPFEGDYTQEQYAQQLIDEYKEAGVAPERVWPQSFHYPDVLYWLKAEPTFGKQAVLLDENGDTPETFPLAVGNLTEYAAAGVKIMAPPLYYLVSVEDGKIVPSSYAIKAKELGLNIISWSLERSGFLGDGTKGGYYFTSVANVTNNDGDVYNLLNVLAQDVGVLGVFSDWSATVTYYANCFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTH2</accession>
    <name>A0A1B7XTH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_14288</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151580.1">
        <property type="nucleotide sequence ID" value="XM_018309262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873369"/>
    <dbReference type="KEGG" id="chig:CH63R_14288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14288"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="855"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1369"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1402"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1443"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1491"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1518"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1637"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="222"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="952"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1663"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="976"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1670"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1684"/>
            <end position="1702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1826" mass="200108" checksum="BA5BF775816F15B5" modified="2016-11-02" version="1">MADNNNNKNNYNNEEQKERPGLRIGRTSNTHQQQPHHLRQHHEHHHHEQHHRQQQPSSPTSPATSSRWSGYGSGSRPRPRSSLVSHPGVPNGNRPKSVHISAEEYKAISELVELAKGLLEKHQTGNDNDVSPSSARNSTSTSSGDSLDISKPPKRGGPLDPFGANFDAREWAKSFYRLRSESCEVRKAGVAFRRLSVSGHGSDTAFQATVGNAWWLQAMAGVRGLLRLKRPEEVRILQGLEGVLKDGEMLCVLGPPGSGCSTFLRTISGNTSGTQVAEDTYLNYRGVSADEMRRYFRGDAIYTAEEDVHFPVLSVADTLFFAARARAPKTPPGGLTTDEYARRVRDVTMAMLGISHTLETPVGGTDGDTARGVSGGERKRVSIAEAALSFAPLQCWDNSTRGLDSGTTVDFCRTLRVQSDMMGMASAVAIYQAPQEAYELFDKVLVLYEGRQIYFGPTAQAKAYFQRLGFVCPGNQTTPDFLTSMTSPAERGREGIIKPGYEAKVPHTPDEFAEAWRTSSHRRRLDQELDAYEASFGLTGSGSGSGPGSRTHYAEYLASKKSDQSSLQRWKSPYTLSYPRQVSLCLWRSLALLKAAPQMTVTMLVVNLFQTVIVASLFYRLSETAESMKSRSTLLFTAALVNAFVCILEVSALFAKRAIVEKHVRYALYHASADAIADLAMSLPFKLLNAITVNTVFYWMCNMRKGGGPFVFFVLVQFAMTLALSLFFRLVASAAKSQATAMAPATTVLLTLALYTGFAVPPMYYRSYAAWIAKLNPVAYGFEALMINEFGNGRKFPCKVFVPSGPTYDAVTAMTMPQTRVCAAQGAAPGATFVDGSAYITGAFGYLDSHRWRNVGIIFAFAVVYLVLHLIVTELVSSEKSHGEVLVFPKDKVPARRAKGDDVEDRLTKGRTETPSMNMSTPMASPMSLKPLAPVLKTNKSENWESEIAGMYTGEGGSPTTMGTEGVYNTNASDKPLPPSPPPPPATAKSWNWPQDRHRPDGHGHDHDHDQSGLGIDRQTAIFHWSNVCYDVKLKKKETKRILDCVDGWCEPGTLTALMGVSGAGKTTLLDALASRLSTGVVTGEMLVDGAPRDASFQQKTGYVKQQDQHLVTSTVREALTFSAVLRQPARFSHEEKMAYVDKVIDILGMAEYADAVVGVPGEGLNVEQRKRLTIGVELAARPALLLFLDEPTSGLDSQTSFSICSLLETLKQNGQAILCTIHQPSAVLFERFDRLLLLAPGGRTVYFGQIGRNANVLVDYFIRNGGPRPAKGKNPAEYILEQVRAGGKQKNGLDWPGIWRQSPEYNDVKAHLARLKDEAGGSARRRRTATSMTTQQQQDPPFAAPFCKQLSEVTRRVALHYWRTPSYVYAKMLLTFGAALFIGLSLLNLPNTQVGITIQTIAIFMFLTTHFNLMLQILPVFVAQRTLYEGREQPSRTYSWAAFMAGQMAVEMLYNALMAPPAFLAWYYLVGLYRNAAETNATASRGGLAFLFMLAFFLQASTFAHMIAAALDLADQAAGIGNLFFVIMFIFNGILATPPTFWTWVYRVNPITYLVEGLLGTGLANAGIHCADNEFLHMNPPPGQTCGQYLQTYISQAGGYLADPAATADCRYCTTSNTNEVLAGVRVRFDNRWRDLGILFMYVFFNAVAAFALYWTRVPKPRRDEDGTSSPSPSPSSSSPSSGQDGNSSTNPLAETWNRLTGKSKVKGGQGGSAAGEPSPRLPWTEEKRADTFLSGHTLHDTQAGKVPGPPRSSANGGIQVLGGSGRTYWDDDGDNADEVQALDNRVENNEKQGSGLGDLSVGEEGDQDIYFVMQRPPTTPQHWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTK0</accession>
    <name>A0A1B7XTK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_14323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151615.1">
        <property type="nucleotide sequence ID" value="XM_018309297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTK0"/>
    <dbReference type="GeneID" id="28873404"/>
    <dbReference type="KEGG" id="chig:CH63R_14323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14323"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="586" mass="66473" checksum="A63DF7B70ADB99B1" modified="2016-11-02" version="1">MLQRINGQSHNGFLLAAIVGPVLYILYSLYLRLLPKPIPGIPYNKNAARSVLGDMLSLAKHATATGEPMDWFRQQAMKHNSPLCQVFVRPFAPPIVLLSDFREVQNMMLSRNKEFDRSRIFRDILGDAGPHHHIMKKTGPEWANQRKLLNDLMTPRFMHTVAAPHIYAGVESLIELWEIKIELAEGRPFDADLDAYYLALDAVVAFSYGASYPHRALLPQIDLLRSFQPKDSARLHQGSTEDAAIRFPEAKVDRALKDTLTMVKTAEVMQASVVPRLTWWWLSKTPKIRNAWKARDEFVAGQIQKAVERMHSMNDAGDEWLGNAVDLIVSREREFAKKEDRIPQYVTQVIIEEVFGFTMAGHESSSSTILWALKYITSSPEVQEKLRILLRRSHSAAFVEKRAPTVEEIIRARIPYLDAVMDEVLRLGSPIPFLARDAETDDAEILGVHIPKGTIVFAHTLGPSMTSPKIDIEDKLRHPASEGSKTGEWSPEDVAIFRPERWLTLNETTQEEEYNPNAGPFLSFGLGQRGCFGRRLGLFEFRISLTLLLWHFEFLPVPEALSGLEARDALTRRPKHAVVKARKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTT0</accession>
    <name>A0A1B7XTT0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151690.1">
        <property type="nucleotide sequence ID" value="XM_018307273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTT0"/>
    <dbReference type="GeneID" id="28871380"/>
    <dbReference type="KEGG" id="chig:CH63R_12299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12299"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="143"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="596" mass="64860" checksum="7A1721215289B4D2" modified="2016-11-02" version="1">MINGFLFSRFYNPLSNHENHSLRVSIARLFGETPSTHNWVSSVLFSPPHLLNRLTMPAAAKWEVIASRHRAKQQQAIPQAWTIPDSKLKELSGTGTGHEGRLIALNALGKSALLTEKELDISGNYTARELLDKIHGRDLSSEEVTLAFCKRAAVAQQLTSCLTEIFFHQGIARARQLDQHMIATGRPFGPLHGLPISLKDSFVIEGHHATVGYVEFLKRPPPTANSAMVDLLLDAGAVFFCKTNIPQTLMTADSENNIFGRTLNPHKTSLTAGGSTGGEGALISFRGSVLGIGTDIAGSIRIPSLCCGIYGFKPTADRIPFGGQSNFPFPILRLPGVTPVAGPMANSVGDLTLLMETTLARRPWDYDASSVNTPWRNLDDGVKTLTIGLLPEDPNYPLHPPAAGHNVVHLPSDPSRSASVGGRLGFSYFGMTSSGLDALANTIGEPLVPSVKRNVHPFNDNKPPISPELDTAHQLSEFLRLRSGYADSWRSTWRDNNLDVVVGPGAISTAVPHDTYGAPVYTLMWNVLDYPAGIIPYGVASKDKDFQYQKAITPFDADYDPEASDGAPCAIQVVAPRFRDEECLQAMRIIDRDIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU29</accession>
    <name>A0A1B7XU29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LipA and NB-ARC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_12385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151776.1">
        <property type="nucleotide sequence ID" value="XM_018307359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU29"/>
    <dbReference type="GeneID" id="28871466"/>
    <dbReference type="KEGG" id="chig:CH63R_12385"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12385"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="49"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="392" mass="42020" checksum="8AC5989EB6A2E6E9" modified="2016-11-02" version="1">MLTRFSAKDRSGDDEDGGSGGSAGEARYSTKGTYGLKKCHDAEDAVADIVFVHGLTGNRETTWTDKSTGVFWPAHLLKDEVPRTRIVTFGYDADVVHFWAAASQNRVRNHAVNLINAISQLRERTDTEDRPVIFVVHSLGGLIFEDAMLASRNSAEAHIRSVYDSTAGVCFMGTPHCGSTLAGWATVFGQIATVVKKTNTSILKVLEPESEVLALIQGDFHTMLRNRADQGRPPLKMTCFYEELPVKGAGEIVPKHSAILPAYNSIGIHKNHMDMTKFSSAEDPGYLSVSTEILRWVRAIQKAQRSAAAAPTASSQTMPSPGLGAPASSQGATGAYLPPGNSHLPLGYGSNAQWYPSGASYSQGDTVISGSINNHGNGKFVTGNTFQGPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUD5</accession>
    <name>A0A1B7XUD5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RasGEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151895.1">
        <property type="nucleotide sequence ID" value="XM_018307478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871585"/>
    <dbReference type="KEGG" id="chig:CH63R_12504"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12504"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="88"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="889"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1357"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1394" mass="150756" checksum="973C05A9B745D2B8" modified="2016-11-02" version="1">MVMLSDHSMRASLQVAPLKLHKSRSCDALASKQQLQHQQQQLQQQQDHPASSTKSSYTSKHMTPPATPNGSQEDLAAAAADQQMPPPVFHNFLRAFYPFHPSYAMTDSSVTLPLNEGDVILVHSIHTNGWADGTLLVSGARGWLPTNYCEAYDPDEMRNLLKALLNFWDLLRSTSVNDSEIFGNQEFMKGIIAGVRYLLERTHCLTRESAMITRNDSLRRARKTLLSELSALVKTAKRLQEAQKGVARPREDVNDIIDEMILKAFKIVTKGVRFFDILEDDRRQRAPAVTVMATVIEETYIPPTPPADHVEFADENNNNNNNNHSNNHRNHNRSKTGSPRKLTNGTPSRGTASRAGEMTTAATASATTTTAATSTTSTTTSRPPSSSSSSSTTNAPAGSRGLSTTVGSPSSPKSHRMSQNVKRLSANISHRVSLAGPSPLSRPHHLVSERLNKSHDTFLSHLGSFIGRLHLQSQSRPELAFAIKLSATSGGELLAVVDVVCGQSTNAEMLARARDMMFERIRELVRAAGQIIRHAVFQDADVIMPQDNSMLLMAATGCVKAAGECVAKTKWAIERVGDFECEFEAGDLGIDLAVLDIGGDGPEHHGRRPSVAPSVAETATTEATSVAAGREGEEEEGGEQGKGSTSARSAADSMQSAVVPPTPHSNHQHPPHHQQRPSIANDKPLPQLPPAVAAAAAAAAAASGSDAAQPASILHRGRPSSQNSSSSAHNSRPSSVNNDGVSSVASSVSSIRPTLPPLPKLSTSLLPGDEYSPIDNTNQDGGDFHGSHSNNNINSGNGSYHRADSIAVSSAGSSTTYLSRDSEASLVSQTSTRATTPDHALGLKLKPSMSELSNAGSANNSNGNNNDEVDDVESKMLEKTYAHELMFNKEGQVTGGSLPALVERLTTHESTPDATFVSTFYLTFRLFCSPLKLAETLIDRFHYVAEAPHMAGPVRLRVYNAFKGWLESHWRDETDREALALIEPFAQFELGAVLPSAGRRLLELAQRVSKDIALVPRLVSSMGKTNTSIAQYIPADTPHPPLAVTKGQINQLFAWRNGGSNPTVLDFEPLELARQLTIKQMNIFCSIMPEELLASQWMKKGGVDAPNVKAMSALSTDLSNLVAETILQYSEVKKRAAVIKQWIKVAHQCLELHNYDGLMAIICSLNSSTISRLRKTWDFVSVKRREMLRTLQAIVEPAQNNKVLRTRLHDHVPPCLPFLGMFLTDLTFVDIGNPPTKQIPTLSGGSGGGGGGGGGGDGSEENGGGLTVVNFDKHTRTAKIIGELQRFQIPYRLTEIPEMQDWMASQIVRVRESDQGQVSYYRKSLLLEPREMAAMRPTLESQTSSASTMTMATAMTPTTTTSSSTASSVTQRGGDLFGWMSRDRGASTPTPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUI6</accession>
    <name>A0A1B7XUI6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151943.1">
        <property type="nucleotide sequence ID" value="XM_018307526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUI6"/>
    <dbReference type="GeneID" id="28871633"/>
    <dbReference type="KEGG" id="chig:CH63R_12552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12552"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="46877" checksum="0198E671BB201A5D" modified="2016-11-02" version="1">MATRQRTSTTTVVEKPQKSNEPVFPDIQTIRDAIPAHCFEPSLVTSFYYVFRDLTMVAGLVWAALTYIPAIQDPIFRATAWMAYGFVQGLVCTGVWILGHECGHGAFSKNTKINDCVGWVLHSFLMVPYFSWKFSHHRHHRFTGHMQKDMAFVPATQPKPSRKPLFGSIDLHELFEDTPVTQLINLITHQLFGWQAYLFFNATAGKGSLQREVNGLGRWLGVSHFGPTSAVFRPNEAIFIAISDIGLAITFSALYKAAQVLDVSTVMLLYAVPYFWVHHWLASRALRLVTFANQASAPSVAITYLHHNHPEVPHYNEEGWTFVKGALATVDREFGFIGKHLFHGIIEKHVVHHLFPRIPFYKADEATESIKPLLGDLYHRDDRSFMGQLWSVFGSLKYVEQDPNCKGAMRWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUU8</accession>
    <name>A0A1B7XUU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152067.1">
        <property type="nucleotide sequence ID" value="XM_018307650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUU8"/>
    <dbReference type="GeneID" id="28871757"/>
    <dbReference type="KEGG" id="chig:CH63R_12676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12676"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="763"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115222" checksum="3051E540C559C819" modified="2016-11-02" version="1">MHAIGPRALASASRVSASSRLALSVAHRSQCRQFHPSYRLRKSPSEGAEDGKPPEKPASEPQDDASSRSRDDALNKTETNSSDSAFRRSRGGAFASARARLARPRPADELPPVKLPQSFLETGVSLYDPVNRINTLTNDLWHQRYMGARWHDLLWKDLDLVFSHASWNKSKLENALRQGNLEAIERRNRILAEASQWLSLSIDEMRSSNNLQSSREPLPTTEFADMLRYSNKFVLSNLLSQHTRETIDADTVQDPDQDSVLQSLVEQYIEEGQPKPRRDGLRLFDPRIRGEVVTAVRAELSLQPDASAAGRELKRPLTVVNIPNYTGRSHTKKLMKHVASCVEADLIHLDAQELAMLVGDYIGQDCAYSRGPMSMLGYRAAEMNGRLAKTEEPSKPNEEDLSGEIEAAWVNLRDHAVDGGYNSPMDNELQKIKEGAKDYVLPSVDRWENLKINAVLEEIAHSASKMTSQPDRSLIIHVDDFVELNMTLEGALLIGRLRAIIDTMWRAGKKVTLVGTSSNENPSDQYASTLKEIAAEECLIPLPLNFQRITNASNTKKIFEANDYLQENLRNIQHMLKTIAGHSPDTSKLRIVGVSKSSPPQFLLDDAEGSYMEVSLIPRVLATSILPLADVYHITRLFYACQGSADPDQSWRVLFDVVESSSYSTAQMHRLQDRPTRSKTSVAGGSAAPSDMQKPEPERLRVSGNYNDYEKKLLSGLVNSSEIKTTFDDVHADAETKNNLKLLTSLSLVRPEAFTYGVLATDRIPGCLLYGPPGTGKTLLAKAVAKESGANMLEVSGASINDMYVGQSEKNVRALFSLAKKLSPLVIFIDEADALLAARGQRNRAAHRETINQFLREWDGMSDTKAFIMVATNRPFDLDDAVLRRLPRKILVDLPLKPDRAAILRILLKGEDLDASVSVDDIARKTVLYSGSDLKNLCVAAAMTAVQEESEEAARHTGPAPYVFPPKRTLRKDHFDKALKMIAASVSEDMDSLKSIRRFDEKYGDVRAKNSQKKRGMGFGVLPTSADAEEARVRQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWM8</accession>
    <name>A0A1B7XWM8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152676.1">
        <property type="nucleotide sequence ID" value="XM_018308259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWM8"/>
    <dbReference type="GeneID" id="28872366"/>
    <dbReference type="KEGG" id="chig:CH63R_13285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13285"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="505" mass="55793" checksum="0C926D798E924AA0" modified="2016-11-02" version="1">MSGASERTSLKDEVAAVENGHSQPGMSSTSRGTRIGHKKSRNGCQQCKKRRVKCDESRPCRNCVRHNVKCSLVLTPFPAPLPAVGESPKPAFEAANTATPGSVREASTTSRPESRPERPSPQLSSLKDKVAAIQGLLSEFSAEVDALNHGSRDSFSGSTHDSVQGESRDAHSVSKADWMVDMQLIHHFTSNTAHTLSENPDFVHLWTTTVPQIAFSNDFLLHGILAISAIHMAHCNPDKREKYATISARHQNIALSQFSPGLTEIGENNADAYVLHAICIFLVNTYSIANPQGPITSRDVAQSFILLQGIRSILALPFAHRYIFNGPLARWLYQGSVEPAVGGNYSSKIDDLLNLTRSMAPSDDTLTCQSALEGLKHTFAAVSTPQHRKGLVWRWAVSLPQSFLELMSQNHPMALVILMYYAALVYAFERNMWYLTGWGSNVASALDKAIQEPWREWIQWPLRCIREGVDIRQVEPLKPVEGNPRTQLPTINFNLGLFKPSEPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXU3</accession>
    <name>A0A1B7XXU3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153100.1">
        <property type="nucleotide sequence ID" value="XM_018306259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXU3"/>
    <dbReference type="GeneID" id="28870366"/>
    <dbReference type="KEGG" id="chig:CH63R_11285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11285"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447751" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="561" mass="61152" checksum="FFA7D3F963DF6DFF" modified="2016-11-02" version="1">MKSLSTLLAALRLADWATPAQGDAATKHTTSSNIANPCSAETFALPLELQDADLVGVTAAEVKGLTFKPLTPEGRAAIPSSGGVSFCNVTVRYVHTGFDDVTQVQVWLPPAAEWNERFVGVGGGGYSAGQFGSEKVVTTLAQGYATSSTDAGHDHKTWEQAPWALNDDGTINERLLVNYAHVSVHDMTVIAKSVVAQYYSKAPRYSYWSGCSTGGRQGIIEAQRYPADYDGILAGAPAVNQPSLIVSTYWPQFVMNQKKFFPHVCEMILMTQLAIDACDELDGVKDGVIADPDRCAFDPASVVGRELDCGDRKMTMSAETAEIAREIWRGPHGADGKPLWLAKGYPVGAPFTGRFGLGNTNCSVAGQGCTGQPFRMSVEWIRNLVRKDPGYDVGGMSVADLEAAYETSRREYDGVIGTNDADLSEFKRLGGKMISWHGLSDECVTMRTSRDFYDRVLAADAGAGGYYRHYEAPGVFHCYGLNGTYYPLKALEALRTWVEEGRAPKVLDGYKVTGGNESEAPTRPLCAYPSSVRFVGGDRDERGSWRCERRRGEREWDRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY18</accession>
    <name>A0A1B7XY18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153185.1">
        <property type="nucleotide sequence ID" value="XM_018306344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY18"/>
    <dbReference type="GeneID" id="28870451"/>
    <dbReference type="KEGG" id="chig:CH63R_11370"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11370"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="108" mass="11756" checksum="8E58A816E6D12197" modified="2016-11-02" version="1">MPEVPTIVTGISDTARYRMGRTPTQIKPQRTSFSRIVKNCAVFGLPMRSKGNPPPKAGNIYSTTETWAPDATPAHPDAYNEARPETSDGSAWGFFPIAGTQCCRLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY24</accession>
    <name>A0A1B7XY24_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153173.1">
        <property type="nucleotide sequence ID" value="XM_018306332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY24"/>
    <dbReference type="GeneID" id="28870439"/>
    <dbReference type="KEGG" id="chig:CH63R_11358"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11358"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="293" mass="31917" checksum="2C5EB045C7A43BCE" modified="2016-11-02" version="1">MTSIGTGYDLSNSIFSPDGRNFQVEYAVKAVENGGTSIGIRCKDGVVLAVEKVIASKLWKPNANKRIATIDRHLGAVYSGMIPDGRHFVDRAREEARGWRETFKTPISTADLAARMGGYLQAYTLYSSVRPFGITAIVGGFDPSTESPVDGEVGSGPKVGAGGKDTSKKHGGPFLYMIEPSGSYWGYYGAATGKGRQAAKAELEKLDLAEGGLTLKDAVKEAARIIYVAHDDNKDKEFELEMSWISDIDGPTKGRHEEVPKDLREEAERLAKKALEGDDDDDEDKKDDDKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY71</accession>
    <name>A0A1B7XY71_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153220.1">
        <property type="nucleotide sequence ID" value="XM_018306379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY71"/>
    <dbReference type="GeneID" id="28870486"/>
    <dbReference type="KEGG" id="chig:CH63R_11405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11405"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="169" mass="19614" checksum="62BF4ECDD7AA0465" modified="2016-11-02" version="1">MKSPLIMDYYGDLGLVETATGDEIEKVYRIVEGKHRAEVDEERLQKVCHDGILTGFVRHYRPQARDAYGLLSRAPERADYDKDYANARTGWFRHRKWTDWEAAAEKTAARGEGGSPENKNLYYAQKLMARMRDRRAKRETVIVNVIGMKKLKGSQRSTLKTMSQTMRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ82</accession>
    <name>A0A1B7XZ82_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_11765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153580.1">
        <property type="nucleotide sequence ID" value="XM_018306739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ82"/>
    <dbReference type="GeneID" id="28870846"/>
    <dbReference type="KEGG" id="chig:CH63R_11765"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11765"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="29837" checksum="07F82DA08F814DC7" modified="2016-11-02" version="1">MPAPTALKQAEAAAPPFEATLQEPQQDEELLLDAPTLPEEMDAILPSVPHNGEEGEMVVDEENRPRFAPARDIDPVTRIETRKVPVPPHRFTPLKSAWPKIYPPLVEHLKLQVRMNPRRKQVELRTSKHTTEDGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYSKAALIMPLETFEIRDVKQVMGNEAQGRAIGRIAGKDGKTKFAIENASKTRIVLADSKIHILGAYKNIHMARESIVSLILGKPPSKVYGNLRTVAARMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZL1</accession>
    <name>A0A1B7XZL1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_11884</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153699.1">
        <property type="nucleotide sequence ID" value="XM_018306858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZL1"/>
    <dbReference type="GeneID" id="28870965"/>
    <dbReference type="KEGG" id="chig:CH63R_11884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11884"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="522"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="649"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR05181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="692" mass="75973" checksum="A06A7B022D912B06" modified="2016-11-02" version="1">MPRGGKRGGGGARAPPRNAPRSRGNDRSAPDSVPGIGPAGFTLQDEARSTAHRSSPWSSDSRLRHRPITFVNTGSSEPLKQLEDILQKEDAAVQPGGTPDVAPILSDNHDTLLDKLDKLASASDEICIPDETLVDVAGDLAILPRQDRCLDANLKSVNEEDNTNSVEAEVPTPLPFFLDTTGDKRLLEKVPIQPAERSPSPVPSDSSEEVILFRGRNKAPRDKRRHKQRKQKQKLKHRPFNLGGIQTEIQAVENTVMSKENDSVRGPEEDKLNSTRQSHQGVRASRNQEDDLIADYIANMREHGDVDGLIPAQAYSRRDIGGSLSESESIEDSFQTITGLDQANMVSSDVSEPDTTVAEVDTTTQPSDAEIPQKTRKHTDMCNSTRVDDGHLAVVETDASHTAFFEQIHPEDVSPQSEPSDQNIEDDLFASAADRFANEVDDFDFMDWNRPALKRKKGKGAKGKVPVFDISDSELEGKMQAAWKNDRLKKAERKKERQALRAQGLLGKHANPEDLRTKYPHGMGLDQIADELRTFLLGTQPSLTLPPMDNHARKVIHELASKFNIKSKSTGSGDQRRPMLHRTFRTAKFADETFDMAITRVGRKYFPRNDIAVRAAVQRQSARRGGGGHAGVLYQDGEVVGGSAPELGQENKGRAMLEKMGWSSGTALGALNNKGILQPVAHVVKRSKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y025</accession>
    <name>A0A1B7Y025_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin rerated protein, other eukaryote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_12055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153870.1">
        <property type="nucleotide sequence ID" value="XM_018307029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y025"/>
    <dbReference type="GeneID" id="28871136"/>
    <dbReference type="KEGG" id="chig:CH63R_12055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12055"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="293" mass="31341" checksum="29979E4CF6EFE969" modified="2016-11-02" version="1">MSTTDKPRGGVDHSHGHHHELPRPHLSAMGGHLVAASGEFVGTFFFLFFGYAGQIMVVLQGADAAPDGSLSSQGVVFIALTYGFSLLVNVWTFYRVSGGLFNPAVSLGLSLGGQLPWMRSLFLIPAQLLASMCAGGLVEAMFPGNISQANSLLGSRTSVVQGLFLEMFFTAQLVIVVFMLAVEKSRDTFLAPIGIGLALFMIMIPGTFATGGSLNPARSFGCAVAGKQFPNYHWIYWLGPAMGGALAAAYYRFVKWAHYEEANPGQDLPVDPEDLAANRVPGLPGLMPHHHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y099</accession>
    <name>A0A1B7Y099_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153951.1">
        <property type="nucleotide sequence ID" value="XM_018307110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y099"/>
    <dbReference type="GeneID" id="28871217"/>
    <dbReference type="KEGG" id="chig:CH63R_12136"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12136"/>
    <dbReference type="OrthoDB" id="4849165at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="131" mass="14496" checksum="2D783F3245A9D9F3" modified="2016-11-02" version="1">MSMDSNTVETLQSNVASQPSTSASSSRYNTYSIEACRLANSDPVSQPDDSSHQAPSSRDGDCREGKDSVNDEKSDGLEAMDQGGFKVMYAERDDRLLDGYFSRLGSKIQHAKDRKARKLAQRRRLLQDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0Q0</accession>
    <name>A0A1B7Y0Q0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154083.1">
        <property type="nucleotide sequence ID" value="XM_018307242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0Q0"/>
    <dbReference type="GeneID" id="28871349"/>
    <dbReference type="KEGG" id="chig:CH63R_12268"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12268"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="4">
        <location>
            <begin position="416"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="64669" checksum="4EBA7D28462AE8AD" modified="2016-11-02" version="1">MASVSKGGRLMLLRPSPTPTRWIGTRGGRGPWALLPLSATAKTASATPTRTTRLLSASRTAVVYFSTHPPRRSDEKESASRPDPVPKPQDGGDSLPKKMLESAATSFASILVLAAGFAIAGYAYHKTYKRIVLKKMTRAFTPGDPVLELAAIGKEVPQNPADADDRWVQRPEQARIDKIVNGSEVGHYFLILGEKGTGKSSMLIEAMRKIDGDGVAMFEAHADLEIVRIRLGKALDFEFHEDYIGGYFSERGPRDTTALLDIERALNKLEKVAIVNRATRKKPLVVIINQMHLIRDDDDGKDLIELLQQRAEQWAASNLVTMVFNTDDYWVYERFKQLATRMEIMSVRDLPKRQAIAALAKYRVKYFNERLSETMLEEVYDLVGGRLSFLNRVAKSSDMIATCKSICQVEKTWFLNQCWILGAEMDDDVMDQQKWAAAAMVLAQALVDSEEDMDLWDEEKGHVLPSFQMHKAQEIMTRADFIRDMDRLNLFTIASNAEVRASSVPMHRAFQEICAQKGFRDHLEKTIQRISDIESLGRTRELVAKDLVLGGKYEIIREGKNGVTVKLTEGEDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0W0</accession>
    <name>A0A1B7Y0W0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nad dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154157.1">
        <property type="nucleotide sequence ID" value="XM_018304733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0W0"/>
    <dbReference type="GeneID" id="28868840"/>
    <dbReference type="KEGG" id="chig:CH63R_09759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09759"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="498" mass="53832" checksum="10EA0F02CD0E6EB7" modified="2016-11-02" version="1">MVQRLFRLPWAYLPSNKAAVAVIASVRVVDFYQIASFQTCITLHLQYLDPGLPLADVARNVGIAQGIFTAAQIVSAPAWGVAADRIGRKAVILIGLVGTAVACVAVAFAGSFQTIVLWRLFAGAVNGTVVAARAAMSDSLPPQHRPAGFSTLVLAFHVANAVGPSASMRSGAGTTSSLGLPDYIGENRLMASLSKQPYALPNLLSALFLLMDALLVWFKLEETSKDAHQIRHMAAVQLQSWTARLRQYRRVPDCEDQTASMMDSSAKNEPILETQQLTSHNQEPTEPLWTPRLFIVLATVAILEFHLGAFGSMWALFVVADRRKPDAPIKLPFTFTGGLQLESSQLGFAMGMLGIIGTLLQFTAVPYYTTKKGAVRSFKASLPLFAISLFLAPYLSLVPAARSGTLWLGIFLVLFLHVVSRSFGILASILLVNQATNLPSRRGTVHGIGNTVSSTFRTAGAMAGGVLYGLGEQRNQVGFGWWFVCFVSIQGWIMGCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1G8</accession>
    <name>A0A1B7Y1G8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transient receptor potential ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_09978</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154376.1">
        <property type="nucleotide sequence ID" value="XM_018304952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1G8"/>
    <dbReference type="GeneID" id="28869059"/>
    <dbReference type="KEGG" id="chig:CH63R_09978"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09978"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="913" mass="100324" checksum="CE0E44F08C7567F8" modified="2016-11-02" version="1">MASTETVYITGQDKDGNTKELAVNRRPGLYTGDFGDCLGGQSLFNITKFDAAYYADNMTVQFHLDGTTNIRNESLMMHINVEAYGETRFEMNFNPCMANIASLCPLNASNPITAFAEFRLTPAQIAGIPSIALDIPDFEGSARIQIFANSSQTQIGCFQAVMRNGNSFSHPAAISSILGVFTVAAILASFATAIYGVSIPHMRTHYAHSLSVLVIFETFQTIFFSGALSVNWPSVLPAWWSNFGWAAGMIYSEKMVSSIDGFAGVTGNASQVGGAGSAVISTGGGLIQQIYGRSLDTLSAPSNTMPINTLLQRAVREYNTSNPYEYYWAGHPVSPGMPMPGKWIGFAGDLSALGIPAADAFTLGLIWWLVVIGLAVVSIAVFKITLDILAGVKLLNQDRFLYFRNHLGGYLAAGILRTLLISFFPLMTLALFQFNIRAPAGPTAVAAVVFILLLVGVGGIVAYACFFRLRSGKYKVGPDTIMFEQGKLFGSVPAVATTRASKIGEEETTAKRYGSMPFFKIQFIDDDPNRTSVHQDEAYIKRFGWLSARYRRTRWWFFSCWLSYQFIRACFIGGGARSPLAQVYGLFVFEIIAFIVFVKLTPFEGQRNTSLAIWMLGITKVATAGFSIAFLPDFAIGRILSTVFGIIIIVVQGFLVVAVLILVVLGLISSWMSLYRNRENFPEKLDATRIRYYEHVQTRAIDLPPPPKPAPQEPQEPPQSYFSVNSVRRTRKIEDDDEDEVGDIIRPQNASVIQFAPGTNTRRSRTNSVSSRYSVGSLPRRARPHRTSWSSADFAEWDADQSASSLAHRGSFGHQRNGSWRQVSHSDSKPNLGRSANNSPVPERAASTNELRRLMTPTEEVPEENVMTPGEMVGPGKPSDKANAVAISPINETDEKYHETKGDASPIEEKTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1Y9</accession>
    <name>A0A1B7Y1Y9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho-like small GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154553.1">
        <property type="nucleotide sequence ID" value="XM_018305129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1Y9"/>
    <dbReference type="GeneID" id="28869236"/>
    <dbReference type="KEGG" id="chig:CH63R_10155"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10155"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="21360" checksum="46932536D7F350A4" modified="2016-11-02" version="1">MDGDAIRILLVGDEKCGKTSFISRLSAGEGTGPITLLRDIDQPFIFEIKLGQNPYRLEFYDTNSPENWKLLDPDIVILCYDISQRLSLINMRRHWLKEVKLSFRRPDRLPILLLGLKRDLRSEDDPNGIIYPQEAYQQAQEMRIDRYMECSAVTGELIKLAFEDICKTAVMTRKAEGGQTEGGCVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y249</accession>
    <name>A0A1B7Y249_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154608.1">
        <property type="nucleotide sequence ID" value="XM_018305184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y249"/>
    <dbReference type="GeneID" id="28869291"/>
    <dbReference type="KEGG" id="chig:CH63R_10210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10210"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16712" checksum="0B04BB647B37295F" modified="2016-11-02" version="1">MFQSVVFDNEGRFVCLQSFLPPPPDPEVEAVFDLPEEEFLALSAKICKAEREEEEKPKPAPEPAPKPEPEPAPLDSSLPPGVDQEDWSIWRDEEVGAEGRLRPSIEDGAVNVSPYLGDLNTVVCRRTKTRRRLDSKPHHLMRTMVHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2N9</accession>
    <name>A0A1B7Y2N9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_10384</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154782.1">
        <property type="nucleotide sequence ID" value="XM_018305358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2N9"/>
    <dbReference type="GeneID" id="28869465"/>
    <dbReference type="KEGG" id="chig:CH63R_10384"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10384"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR06264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="667" mass="73055" checksum="2BAC141434B9D20F" modified="2016-11-02" version="1">MDIDTTPASYGTPASASAGPGPEAMPAPSPSAHLPSFESHPSATAGQSIAAASAAAAAAAAAASTGSAQSRPCDICRQRKTRCVREEGRDKCVMCSFHGQPCTYLRGPLPRKRRKATDPPEHRPSTATNGSVSAPAGPPPAPVPLDPQEEITHPSPELLEALSPSLAGSEHAITFNQPSLLDGTLGLHLKTHSEYVGNTNYREPSLLDLHRPHDPAIRSVRRLDESTVFLIHRDRETSSEPQRIADLDAIEKVVHPLGSTLVNLYFRIVHPSFPVLHKKVFLEKYARSYHEFSPPLLAAVYLLALDWSLYDRTLATSSWQPDQAALEALALRTMSDDMKRPKISTLQAGLLIQQRFRNNTWTFTAQLTALAQGLGLHVDCSDWAIPDWEKGLRRRLAWALFMQDKWGALVHGRPSHIRLDEDWDVRPCCIEDFPENAADEEHDPEGSAEVVVGRELFLRHIELSLILSDVLGTFYTAKATRRGGTLDQIGTVGVAELAKPIVMMLREWYAKLPEALQLQETRLKKLSANGSLHLAYISIDLALHRSLVRNISSNAPPELRVAIRTGARARLAAASNIIANLQMEHIQSFWGFAASAQLAGIGSFAGLLWATSNDDAEAMYYADRVEEYLWSLRVRAQAAPFAREALRMLESDVSGLGAVRAAAEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3G7</accession>
    <name>A0A1B7Y3G7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155087.1">
        <property type="nucleotide sequence ID" value="XM_018305663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3G7"/>
    <dbReference type="GeneID" id="28869770"/>
    <dbReference type="KEGG" id="chig:CH63R_10689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10689"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601293" evidence="2">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="122" mass="13935" checksum="4A36FBA7656E7DC3" modified="2016-11-02" version="1">MLGPTFGIAAATSLIMAVLPYDFISNNEITTDGKLVDGISRWLTEFTRSVVSRNFHSYNNYWRPYLLFSALAAGWSFTLFEQARSIFNTQLDMALVLLIDVKTNPTDTWPLLVKQLDLLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4R9</accession>
    <name>A0A1B7Y4R9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsule polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155549.1">
        <property type="nucleotide sequence ID" value="XM_018303526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4R9"/>
    <dbReference type="GeneID" id="28867633"/>
    <dbReference type="KEGG" id="chig:CH63R_08552"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08552"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="40463" checksum="1C6EBC5FE7CCB32A" modified="2016-11-02" version="1">MASAIAKATRTEADFDRFPVRVVRFIRLATAGGLAYAAYRIHWRIVLASFFTGPGRISRILMLIFALLNLKNMPFVWTYRIWHAIIYHCFIRKSPRLGPRSLFRPMISQSHAPIMEIDYNIHKSNSTYFADLDVSRTHLCTYLLRPGFRQLTHNATTKLVIDPKSGKPARGPLGIMLGAVHCSFRREITAYSPYEMWSRILSWDRKWLYVVTHFVPRGTARPTEWLDPKFGTAHVRRRPSSGSGDADSAAAWEKKIYATGVSKYVFKIGRLTVHPAVALEASELLPQRPGGWTGGDAGVGDEDVDLSDVADDGAWDWKMVEKRRREGMKYAAAFASMDDLHGWLDGADGGDGSALGKFGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5S6</accession>
    <name>A0A1B7Y5S6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA/TS-N domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_08922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155919.1">
        <property type="nucleotide sequence ID" value="XM_018303896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5S6"/>
    <dbReference type="GeneID" id="28868003"/>
    <dbReference type="KEGG" id="chig:CH63R_08922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08922"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="700" mass="77005" checksum="48C4E4246E31EAF1" modified="2016-11-02" version="1">MAGVLSKRQQARNEKVLHDLVQSVPGNNFCADCQARNPAWASWSLGVFLCMRCAAIHRKLGTHISKVKSLSMDSWSNEQVEVRPKFAFVNLHGDALTRRPQNMKKVGNVRSNQIYNQDNKKPPVPVDADEADSAMERFIRTKYVNNKPVPVRKQHSSLSDEGIPPPLPPKSGGKFGFRSASSIFPLSSRLKKDSSLRSTMSSPRDMPRSPSPTDLPNKPSKVFGASVSYEQEDTERKLVSLRDMGFSDGQRNAMVLKGVSGNLERAIETLVRLGESDRRSPSLTGPRESSLRGSRSHANLSASSGLSAPQPTFSDHTQSPSTASSNNPFDMLPPQPQSSQSTGTLQNKNPYANNPFGAPTQQQQDVNQAFGNLSLAPAQPLFPHHTGGLPASQPFAQPQQMYHQSMTPPVPQQQQSYNPMSFNNSNMTYPQPIQPQATGYNPFFTNQMQPQLQQNLGVNTAPTSSPFANNPFTRSPTRIQSPSLGQIPEQSQTSFYTDSPQTASPQTSNPFFAQRGSQLPQPPPQQSYQQQFQQEQNPFQQQGQQHFQPQGQQHFQQGQPLFQQQETGQHQYQAPAPQPAYQQPQRPDKASILALYNYPQLAPQTFAAHAQPQEAAQTETAAPRQPDHDTNGSMQTAGNKNPFLANGTTSPAVAPVQGIGTEVGPRKPGVSRESMAFTDMQWTNGRHSPDAFASLSARHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y755</accession>
    <name>A0A1B7Y755_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mcm2 3 5 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156384.1">
        <property type="nucleotide sequence ID" value="XM_018304361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y755"/>
    <dbReference type="GeneID" id="28868468"/>
    <dbReference type="KEGG" id="chig:CH63R_09387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09387"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="85950" checksum="546C32D94AA82936" modified="2016-11-02" version="1">MAWDDPPKSSASWHNDAEEMGDLGRATPRKDDSLHQGSIAGPVSGKSPLRRNGNLAVGPDQKDDDDMLYKRFSRPPTYCDSRKDVHRKKHNWLSVSILALSVYSTGLSCLWFIVAVVQPRWGPQISSSGGILPSTASLVCAMFAKTIEISFVTVFVTFIGQVLTRRAFVRKSKGMTLAEMTMRNWVIQPGFLITHSETLPYAGMTLLGVVSLIATVASTLYTTASDAMVTPKLKYGGWESKTLSGYVLASYANPPFARERCQTPLRDSDPAGVDTAGPYRNLMSFLGDWDAINKNGTSATVDISQRPVGTALLYDNTTLTSAWIEVNFSNATKNYEEHGRVVNNVTLAMPHPSVYDAATNPVNKILQPNDLSGVGEYAIKASVVSPALNVMCVNMAPDELAPLVYTEWPLGQVNSNDTLVPGQRIGPLDWEHYVPGPSETEWLNRTSVDDIFRWGEQYNRRPPVFQLYPADFNMVTNTTTLNDAIYILTKSASVADYTLCEMRSWVSPLCSTHFNISGTTGAHMQAHCEDPEDEDSYNHVHPEVTFSVPVVDWKNIADQWRLSMDINGGAQNNNASNARILTQFVLKEPRLDPLLPSIAEALAVYASSTIIIGGHGTPFEHYWRHDKTQLGAPGSLDRFEASIRTQEYTSGHVAEWQKAFYVVLVVVVGINVVCLAYFLGRSGLVTDFTEPQNLFALAVNSPPSEQLKGSCGGGPVKRDLVVPWRVAYASGANHYFFEEASDRPWRGKYAGQDLLSADTAYHGRQRSSYQRLSTSTSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7Q4</accession>
    <name>A0A1B7Y7Q4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium/calmodulin-dependent protein kinase type 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156532.1">
        <property type="nucleotide sequence ID" value="XM_018304509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7Q4"/>
    <dbReference type="GeneID" id="28868616"/>
    <dbReference type="KEGG" id="chig:CH63R_09535"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09535"/>
    <dbReference type="OrthoDB" id="4837942at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="40504" checksum="D33F06F3B525210E" modified="2016-11-02" version="1">MQKRCHVAGQSSYGGSSWLGAPSDASSGMNAEHGLESVQQAETQRTLMRLHGSGSGSGSDASMTYRGNLGDLGLGVAGVDMPGQTHANTLPESRNDTIEVRVNEPRRGRESHLQLEDTEPFNPVSPSDFFQFSPSSGSDKFDPMLGFNTESPGLPSTYQSINTPSTSQWATPPAGLRESRRQSNHASPEALDKTDVPGPAAEGDGNSMPGSRLERRSSKAGGHAEPAAAGRRPPQVDDDEWSTPLLAAAGRGHVQIVKLLVKSGADLESKSKSGKSCLFWAVEMRQMDTVKCCLDLGADLGAVRDESGLGLFHRAVLDDDVPLLEVLLECCARLGEKGREWVHMTDRHNRTPLYLAAEMGKAEIAELFVKAGADVNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9L1</accession>
    <name>A0A1B7Y9L1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157198.1">
        <property type="nucleotide sequence ID" value="XM_018302420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9L1"/>
    <dbReference type="GeneID" id="28866527"/>
    <dbReference type="KEGG" id="chig:CH63R_07445"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07445"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="484"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="543" mass="58345" checksum="A2452E0776BDB522" modified="2016-11-02" version="1">MLRSAPARRAASGLANSRLTLGPRTCAKSLSTCSTRFTSSPAAIYPAANSSSRSANFTSPFSLQRSIHTTAPRMTETRTESDAFGEIQVPADKYWGAQTERSLENFKINQPQDRMPPPIIKAFGILKGAAAAVNVRYGLDEKIAKAIQQAAAEVADGKLLDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGVKGSKKPVHPNDHVNRSASSNDTFPTVMHIAAVLEIENELIPSLKSLRDALQKKVDEFDAKNIIKIGRTHLQDATPLTLGQEFSGYVAQLEAGIKRVESSLPDLRLLAQGGTAVGTGINTFQGFAEAIAEEVSKMTGTEFKTAPNKFEALAAHDAIVQAHGSLNTLAGSLSKIAQDIRYLGSGPRCGLGELILPENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVATTIGGMNGQFELNVYKPLIIRNLLHSVRILSDGMRSFEKNLVAGLQANEEKIASIMKESLMLVTTLNPKIGYDMASKVAKNAHKKGLTLKESALELNALSEEDFDKLVRPELMIGPSAYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9L2</accession>
    <name>A0A1B7Y9L2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157153.1">
        <property type="nucleotide sequence ID" value="XM_018302375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9L2"/>
    <dbReference type="GeneID" id="28866482"/>
    <dbReference type="KEGG" id="chig:CH63R_07400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07400"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="107" mass="10887" checksum="4054C847CDB7B894" modified="2016-11-02" version="1">MPNRDSGYSSGAPIPAPDSSRSAVLGDIQKAGGIKALKKVDRTQIRDRSAATVGGSSDTGPHGSGLPPTGVAPGGGGDMANALAAALQKRKEKVSRSDDERSDNDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA10</accession>
    <name>A0A1B7YA10_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157216.1">
        <property type="nucleotide sequence ID" value="XM_018302438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA10"/>
    <dbReference type="GeneID" id="28866545"/>
    <dbReference type="KEGG" id="chig:CH63R_07463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07463"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="38866" checksum="2C8A7345BFF43AEB" modified="2016-11-02" version="1">MAASRVLRDLSARRASRPPASFSSATVRPFSSTAQSRLKALKNPPPSPAPYTSQFPPAANAADAALANLSHLTPAQITALLSTPPKPPPPPPGGVPQPDGQQPPRSRLSRSLWALAFFVLGYKLTADEIATWRFAYPFMHPPVETKDPDEIAMYREHATYDALEDYPILQSMVPQVNEAGTRATPTDWEQWQPYEDFSAETLSKHLCGGTLNNPNALGLVHLVFRNRLTGEIILAIMFGDGTSGWPSIVHGGMLSTIMDEAMARLAALNFSANTAVTARLSMDFKIPVSPRMLYIVRVNKVLPEYQKQGSDEDKTDRKMWIVGRMEDPDGATVLEAKGLFVVPKGGHMQPLGKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA56</accession>
    <name>A0A1B7YA56_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157353.1">
        <property type="nucleotide sequence ID" value="XM_018302575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA56"/>
    <dbReference type="GeneID" id="28866682"/>
    <dbReference type="KEGG" id="chig:CH63R_07600"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07600"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="179" mass="19485" checksum="54F2DF4F299D8291" modified="2016-11-02" version="1">MTRLNPMSNTNCDVDGPWVVIGTVGGPNYTRTRSKRQRTSMKPRSGRSSSPRFEAWATTDALRDRLALAPRAGAALSDDIRHTAPPRGNLRIADSRTRAVDDAGASSPFEVATLAPFPPPTDLSLNPGPEFRPACLEPYSVLNGDDFVAIFSIYGKPSHEQPMTEGDGFMTCEPHFLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA70</accession>
    <name>A0A1B7YA70_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157508.1">
        <property type="nucleotide sequence ID" value="XM_018302730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA70"/>
    <dbReference type="GeneID" id="28866837"/>
    <dbReference type="KEGG" id="chig:CH63R_07756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07756"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="843" mass="93313" checksum="739681696CAE2A64" modified="2016-11-02" version="1">MVNFTIEEIRGLMDKPTNVRNMSVIAHVDHGKSTLTDSLLSKAGIISTAKAGDARATDTRADEQERGITIKSTAISLYHNVDPEDVKDIVGQKTDGTDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVIINKVDRALLELQVSKEDLYQSFSRTIESVNVIISTYFDKSLGDVQVYPDRGTIAFGSGLHGWAFTIRQFAVRYAKKFGVDRNKMMERLWGDNYFNPHTKKWTTKSSHEGKQLERAFNQFILDPIFKIFSAVMNFKKEEVATLLEKLNLKLPAEDREKEGKQLLKAVMRTFLPAADALLEMMILHLPSPVTAQKYRVETLYEGPPDDEAAIAIRDCDPKGPLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGIKVRIQGPNYTPGKKEDLFIKAIQRTVLMMGGKVEAIDDMPAGNIVGLVGIDQFLLKSGTLTTSDTAHNLKVMKFSVSPVVQRSVQVKNAQDLPKLVEGLKRLSKSDPCVLTMTSESGEHIVAGAGELHLEICLNDLMNDHAGVPLIISDPVVQYRETVVGKSSITALSKSPNKHNRIYMIAEPIDEELSKEIEAGKISPRDDFKARARILADDFGWDVTDARKIWTFGPDTTGANLLVDQTKAVQYLNEIKDSVVSGFQWATREGPVAEEPMRSVRWNIMDVTLHADAIHRGGGQIIPTSRRVLYAAALLAEPALLEPVFLVEIQVPEQAMGGVYGVLTRRRGHVFGEEQRPGTPLFTIKAYLPVMESFGFNSDLRQATSGQAFPQSVFDHWQPLPGGSPLDGTSKVGQIVQEMRKRKGLKVEVPGVENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YC64</accession>
    <name>A0A1B7YC64_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Squalene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158230.1">
        <property type="nucleotide sequence ID" value="XM_018300380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YC64"/>
    <dbReference type="GeneID" id="28864487"/>
    <dbReference type="KEGG" id="chig:CH63R_05405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05405"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="322" mass="36679" checksum="E4D18425E73F61DE" modified="2016-11-02" version="1">MSESPAVTPTVEGLRHHLSCLIPDFLKCINYTQPPKADQDALREALLERGRQAGVHVEPEDGSNMRFEAGLAVAAVCKPDGSMREIDKHELFRLTTLVQEMYPLHPFDIQVHIGLFTWLGFIIDDLNAELGSDLDNFQSRFFRGDTQPCVILQCFASVLRSTTDYYDPVVANLIVLSALAFVNSNAIELRREYQTIALTREALSWPYYFRDKEGLPEVYTYFCFYKEVCPDISRFMPAAPEMGKFINLTNDILSFYKEEKAGEVRNYIHKKALCSGCSPLQVLESTISETAIAYTRTLAILKDSHPYDDICDSWDKVFTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDE2</accession>
    <name>A0A1B7YDE2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158582.1">
        <property type="nucleotide sequence ID" value="XM_018300732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDE2"/>
    <dbReference type="GeneID" id="28864839"/>
    <dbReference type="KEGG" id="chig:CH63R_05757"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05757"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="273" mass="29435" checksum="6E58110A78AA86BA" modified="2016-11-02" version="1">MSLIRLIIRTAPPTTQSIPSLRLFTLRPLLRKSLQPRQPCSPRRPFASAAPNPAPRTATSNPTGAGGSARTGNPRTGRTAFLAFWKITSVFSCAFFCLVAAPSYIRAEDKTLVQATGLAACGIIPLLFVAYTSAPFVTYIYLRLPPYARQSRALLERYVRTLPPTAQLEIGTMGLATRPRTTLVTAADLRPVTSGAAGGSLAARLGLVTHVRDVSALTAKRKWHHYRPVSQFGIREDIATSGGGSKSSGKGASYGVKDGWVWTIVRESLGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDF1</accession>
    <name>A0A1B7YDF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Helix-loop-helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158640.1">
        <property type="nucleotide sequence ID" value="XM_018300790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDF1"/>
    <dbReference type="GeneID" id="28864897"/>
    <dbReference type="KEGG" id="chig:CH63R_05815"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05815"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="182" mass="20591" checksum="8C0C320CAFFEC640" modified="2016-11-02" version="1">MRREGPDLRDIPPWCETACDRAKHTPHLPLPDIKPDHHTTAYEIDPTDSKHTCIGTAADCACIMSSPNKSNSPSAPADAEQPEEKPRLTEAEKKQNHIASEQKRRQAIREGFDRLTELVPGLEGQGRSEGLVLKKTVEFMKEQLRQRQELVDRIESTGGEVDEKYKRPLFHQQANSTSSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEQ7</accession>
    <name>A0A1B7YEQ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orf21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158901.1">
        <property type="nucleotide sequence ID" value="XM_018301051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEQ7"/>
    <dbReference type="GeneID" id="28865158"/>
    <dbReference type="KEGG" id="chig:CH63R_06076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06076"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="224" mass="23899" checksum="3BD018C90E94FF20" modified="2016-11-02" version="1">MAFKRKRSDSELFASFNSPAGSDSSIESFECPVSPSPVYPRAYVTPSHLPSRTMKRFRDNRPSENQIHQRTLNMLYSAQQQNHHKTNQLGDANLEPSSPSPAARNTQQSLHSFWNIKSAAPSLSAASAPPVDQATLCPVSCDDCGAGLGSSDGGAPDGMDVDDAYAYGAGFEADHACGACGRHVCSHCSITNLGEQRRCLRCAGRTAWGDGSRAGLSASSMRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YES2</accession>
    <name>A0A1B7YES2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_06122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158947.1">
        <property type="nucleotide sequence ID" value="XM_018301097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865204"/>
    <dbReference type="KEGG" id="chig:CH63R_06122"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06122"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="12">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1238"/>
            <end position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1285" mass="143547" checksum="ACE19BB92E3F3959" modified="2016-11-02" version="1">MEQATPSAVKPCSLFTSRDPENAGDIMSELKNWTREAEIAVLDDVATAQSDSSGSTPSPPGQPSEETHVDRPETPPRPCPPSPSNPDLRLPGFAHIYGDVDGLGYNETSVDIVCVPCPGADPVDTWARDPLREGCFGRPGDDVHVPSQPIGRHFPRATRLWVRQGIRKEVSKARVLLYRHRELADGVTLDELADDLIEQVWSVRYGPQRSRPLFFIAHSVGGLVVKMALLRATRRVEYKPFMYNCHGISFFATPHRGSSYLSMNNLEDSIRRLLRLQRPLPRSISDSLRLGHKPLLTMHEEFSKIASELRIWTFYETIDSQLSGSGSTSRGPAKEVRFGAPIASIKSSLVGVRQERVFSLDSEHADCASFGEGNAETMAGYLRELAAAVDKATALSEMHVHTPLNLKTRVKVEIIGFFEDPDAEMESAIRLYFTKLHLQEFLDKGPERCLEERLRRTALRPSSDPAPAPAPIPPAGPDQEDSQTSNNGGLGILSGFQELGQKIWPGRSDSGSRPKSSDSESQDSPGIVVTRPSIAVGSKSAPVDAVRRMQSLKVPALSPPGFGRPSSRSSNAESTRSDPTELELSPRAAANAESPGVEVGLEKSNSEPLSRRQDRLSRASALDDLTAGFSRPDPASRKFMWIHTPFTNPSWVKDVLGKLANPHDPSFIKASNSDNWASKHVIGRHSQSQASFVKPACSFIPPGSASSPHPSPSLSGRTSPGSGPSSAYLYMYLPFLHFDTYINVLRRRNFIKRRMQHGRSRPVPSEIAQLESAELRMIWEYIGYDPPLNYRRTLDQFAYPSLRDTWARDDDQMLYKLTKNHSPSGADRDQLGLQRRQTSGSAWSPTEKLTPSSTDLPDEEPTNTEDEDQDLEEAIRDGKVLMVDQLWLWAIDTTTLSTFFNRRESRPKEGPLFQQADLRNSVYNELNGDLTGRCENALDLAAFIVLHAVTVLLDRSSHPDLEVFRIFEEAISMLTERMTSSLKRFRMQTFKDFGGGGGGGVDSDSDADSNRPESIKKRHKRELEEAERENRENTSALMELRDLEDELKSLERLFETQDGVVRNMKAVLEADEVRHQTHNGQMYLDEALHKLDEYKSQTMEMLKRVDTTRNDYEKLLEMVQRKAQVDEVRWSRLQTELASSQNLSVMIFTTFTVIFLPLSFFTSLFGMNTAEWEAQVPSIRFVGAVSLPLSAFIIAAALVAAFSGRAQGLVRTAYKGGKGAVGAAAALLGKVVPREKRERRHVKRAEKAEKKPKKRDRGYDFWQSVRRERASEYRIPEVNRNKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFA5</accession>
    <name>A0A1B7YFA5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division control protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159246.1">
        <property type="nucleotide sequence ID" value="XM_018301396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFA5"/>
    <dbReference type="GeneID" id="28865503"/>
    <dbReference type="KEGG" id="chig:CH63R_06421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06421"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="181" mass="20170" checksum="6EA9D7AF49DA94A2" modified="2016-11-02" version="1">MASPSALFDLGQGRRDLAALPADWQQNIREAWEVVDQQGLGSLNAREWPFALRAIGFDLARTETYALLVAHGVPPHDHDPSRGPCSPSRLRMPQEHFSAIAAWLLMRRDPHEEAEDAWKMFDPRGTGRITLESLRAVCAEVNSTLSEADMRRMIDMADISGKGWVSKDEFIEVARGGFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGJ0</accession>
    <name>A0A1B7YGJ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolase, family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_06885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159710.1">
        <property type="nucleotide sequence ID" value="XM_018301860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGJ0"/>
    <dbReference type="GeneID" id="28865967"/>
    <dbReference type="KEGG" id="chig:CH63R_06885"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06885"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18820">
        <property type="entry name" value="GH43_LbAraf43-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43817:SF1">
        <property type="entry name" value="HYDROLASE, FAMILY 43, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601642" evidence="8">
        <location>
            <begin position="23"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="326" mass="35956" checksum="FA650C43AB2368B9" modified="2016-11-02" version="1">MFLSKIVSASLGLLGLVGSAAAYTNPIRNPGGGDPQISWFDGYYYFISTEWTNLQLARATTIEGLKTATPKVIYSDSNPTRCCSVWAPEIHYFDGRWYLYYTAGNDGNLDGQRMHVLQGGASPWDDWSYAGRVTDDWSLDGTVVRFNDWGNYFVYSCMTGVPNQSTCVRKLNDDFISASPNITIISQPDQPWEQSEVPVQEGQYGLYFGGKTYIAYSANYCWTPDYCVALLEWDGVTDPASPSAWTKSDGCKLTAANGNFGTGHNSFFRSPDETETYITYHATANANGACDDNRYVMVQPITANADGTPNFGVPQGFGFEWAEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHY5</accession>
    <name>A0A1B7YHY5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160087.1">
        <property type="nucleotide sequence ID" value="XM_018298841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHY5"/>
    <dbReference type="GeneID" id="28862948"/>
    <dbReference type="KEGG" id="chig:CH63R_03866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03866"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="90"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="360" mass="40929" checksum="5B3F9643B486BC89" modified="2016-11-02" version="1">MLVINSADSFWTRWFETLTFPAHSIRRFKQTKLLSSSQFLVILPEYAERMLPTYIPVQKVKAKNGIVYAYRRLGPARGIPLVLHMHVRASMGYWDPVFIRPLMAKRPVIMFDPPAAGQSSGDTKRTPTNINIMGDDLNAFLDALSLELIDLLGFSIGSMACQMATLARPERVRRLVLVGADPSGPIPGEHFWPRTDPNLDRFLTLQQSATEEDWQAAYTLTFFRDDDQGRTAAGAYFRRLRESEFNERAAEGGLPAFNDVESFMIQLKCIKDWCAPGDRSKHSFYRLAELTMPVLVMTGDDDYLVPTPRSYELMDGILNCMLVIWPRAGHASIWQYAENCAAKVNEFLESDMEKFAEPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI11</accession>
    <name>A0A1B7YI11_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic-type endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160213.1">
        <property type="nucleotide sequence ID" value="XM_018298967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI11"/>
    <dbReference type="GeneID" id="28863074"/>
    <dbReference type="KEGG" id="chig:CH63R_03992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03992"/>
    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601699" evidence="3">
        <location>
            <begin position="23"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="629" mass="68015" checksum="2C9DB01E5DE7E1A5" modified="2016-11-02" version="1">MLPPSPWTALLLASVFSPAALAVDTCSNSVEPLVLPIKNVTFPNGIGANRGLKLTLGGQLQGMRMSTILNNTRVRNSLDCPDNTTYAFVGCQGSSGSVYDTTRGSFDQVINIHDWNVTTIDAQPDEGRTTVLHGYDVANFTDAPAVAFGYPFEVWADYDSMNKSAVALGPNSSTLESFVRNGLAPAGSFSMDYGSTSERYPRDGQLVVGGYNEARFNDSKVTRFPMWGANAPVPCPLQVVVSDILLTNKDGDHSLFDPGVRVAACIDTVQNSFTLTPSMFSKFQKLGNRTESDGQAFAESDFPADREPLLGSLTIKLSNGYTSVIPHYELVNHVRGTDARGRYAVLNNSRISTTVASGLSDLGDNIPILGGVFLSQNYLHVDYDAGSFWLSPQVANGTLPDHITASCNGTSSATAAKSALGVKVGVPVAIGVAVVVFIGLWFWLKNRKRNPQAQFADAPRSIPRNEKRDAPDSKSSTTNFAGYHNAAGYHNATHANPDAHMELEGDLARRSMGLNLNPRQRAELAEPVPAYKSEWPRQNSIQGENDTYYRQFEEPGESYELADTSPYSQSVTPPTHPPPVQRKDTALSDNWVPSPATLRKQVSGFNDAISPTSTRANSTRVNNTHPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIF4</accession>
    <name>A0A1B7YIF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_04149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160370.1">
        <property type="nucleotide sequence ID" value="XM_018299124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIF4"/>
    <dbReference type="GeneID" id="28863231"/>
    <dbReference type="KEGG" id="chig:CH63R_04149"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04149"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="760"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="799" mass="88065" checksum="DC0AB3D2D7225D1F" modified="2016-11-02" version="1">MNPSPNEGPAGPSTGGSGSFDPSIPTSGPSTAAAAKRSRILLSCGPCRASKLKCDRSEPCGQCLKKSRPEGCVYAPKPEKAKPVKGMAARLKRLEGMVRTMMDEGAVAAAEPQDSSVGIADVGVAQPGGQFVQGERASTYVGATHFMAVLEDIEDMKSYFEEPEFVEDESSEPSDELESPDLLLFSTNAPRNREDMLRLIPERRIADRLVMRYFSSQSPSQHIIHRPTFTKQYARFWADPHGTPSHWLAQLFMMMSLGIFYSTFMAPHELPTDSSLPPMDRFKLFRSAAAWCLVWGRYTQPSMATIPPFMLYVEAEFIVSRAAQTNGYVLSSVCLRLLLKMGLHRDPDRLANVSAFEGEMRRRIWNMAVQLDLLVSFHMGLPSMLSGIDSDCGLPRNLIDEDFEEDTAALPPPRPPTDYTEMTYPIQKTAVMLVFGQVARQAHLLSPPPYSEVMRLDGLLHETWAAVPRFMMVRPLEECITTPPTLVIQRFSLAALYNKTRCVLHRRFLLEPLPRREHDYSRRQCLEGAVALLDFQNIVWHACQPGDILSQNGWFVSSLAVHDFLLAATIVYLAAGHGPFWDGGVEHAWMAEMSPPPTRAHLLHLLQRSHSIWTNVASGMPELQKTAGFLQTMLGKLGSPPNSPPKEKDSGKAATSGPSEGSSSLSGGRWSADSRETQLFNSLSIGGTSHLDSTGSRRLVDDVAGPTLNHSSTANTLQPFDFITSDLGSGDTGLDRGWVAVGDEMDWRYFDNIMAQPNNDPIGLESLDPNPSWFGRASAPDDFDFPASGPWDSTLGRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIJ6</accession>
    <name>A0A1B7YIJ6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_04195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160416.1">
        <property type="nucleotide sequence ID" value="XM_018299170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIJ6"/>
    <dbReference type="GeneID" id="28863277"/>
    <dbReference type="KEGG" id="chig:CH63R_04195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04195"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="398" mass="43213" checksum="E04A888453265C5B" modified="2016-11-02" version="1">MYSAPRAISRLAREWRLVNPRLSTTSSASSCSFSSTATALSSSSSSSKPRPQSRPRPSAPPPPFELVPTCPSPTCECAATPAMPDGLDIDRTAPLNGVVSAYAEQVLACTGRDDWASRIEEENSGDNLAADLKELFGRGGTYSDPWHNVSVLNASFPSSTPRRSELQTTSAYLLPSFKYVPFLPRVSFDSVQALAKGYLLPEKLHPMHDGLSPIHRDRLTREAAYRPLLYGVRDVTDVLVLICGHGGRDMRCGVMGPVLREEFERRLEGSGVAVARGPVEVDEGGEEKGRIAAPEGQEEKKKKKEEEEEGGDGEMAARVGLISHIGGHKFAGNVIVYIPPGLRMTSGEKHPLAGKGIWYGRVEPKHVEGIVKETVLGGRVIADMFRGGIDENRKILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ34</accession>
    <name>A0A1B7YJ34_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160375.1">
        <property type="nucleotide sequence ID" value="XM_018299129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ34"/>
    <dbReference type="GeneID" id="28863236"/>
    <dbReference type="KEGG" id="chig:CH63R_04154"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04154"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="146"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="257" mass="27878" checksum="5D7C599F9D8EFE4C" modified="2016-11-02" version="1">MTMTAAAVPPPPPPPPTLSLSTDRSEQHSCPSCGVVLEPPPALLEAQSRIADLEAQVRLLNQKAAAAVDRWADYEDELTRLRIAASQTSTSPAAAAPALAPTPSPTRTSFLSGGANRLSQLLSPRGMKSTPNLRAPSPPPPGTPASTEDLREALSREQNLRLAAESRLSTTSQEVEELSVSLFEQANEMVATERRARARLEERVETLEKRDQDKRRRLERLEGAVGRIERVRSLLGEMNAKDAGVREAAEQKRASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ39</accession>
    <name>A0A1B7YJ39_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_04326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160547.1">
        <property type="nucleotide sequence ID" value="XM_018299301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ39"/>
    <dbReference type="GeneID" id="28863408"/>
    <dbReference type="KEGG" id="chig:CH63R_04326"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04326"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="75"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="231"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1174" mass="135955" checksum="F2EFC4177592A3AF" modified="2016-11-02" version="1">MSYDNDIHSPNEMVVDTDEYVGVTDSEKEPIAIISPDNLDNEAEQLQDLPMANDFDAMKEIIFPHLHEEPEIVEDVVNTWTVEAWRSMSKKEHGPVFQAGGFPWRILLFPHGNNVDQCSIYLEHGFEPASIPDNWSCCVQFALVLWNPDDPSLYTHHTAHHRFTKEESDWGFTRFLELRKMFNVPWEGGSRPLCENETANITAYIRIVKDETGVLWHNFNNYDSKKETGYVGLRNQGATCYLNSLLQSLYFTNAFRKAIYEIPTQSEESMGNSAYTLQRLFYQLQTSDQAVGTNELTKSFGWETRHIFEQQDVQELSRKLMERMEEKMKGTPAEHVLPEMFSGKIKTYISCVNVDYESSRVEDFWDIQLNVSGNKNLLDSFKDYVQVEKMDGENQYYAGDEFKLQDANKGVIFQSFPNVLHLQLKRFEYDIQRDTMMKINDRYEFPEIFDAAPYLSEDADKSESWTYQLHGVLVHSGDLNAGHYYAFLKPEKDGWFYKYDDDKVTKATMREVLEENFGGEYRTHPANHLRAPLQKKAPVVRQNSAYMLVYIRQSRLDNILCPVTKEDIPLHLRSRFEEETALKEAKRKEKEEQHLYIYVKVITEQTFKAHGGTDLTSFDADHAEDEGAPKSYRVLRSSTMEELVATIAESLDLDPRKVRLWIMVNRQNKTIRPDQPIMDLRPTVEECFQRAAAHRDQFLRVWAEVAEETTPEGEAVWPTYQGQLNGVVVKNDLILVFLKHFDVEAQSLHGIGHVYISKEKKVEELVPIIMKKMGWGDKLPSDEKICLWEEIKPTMIEALKAKQSLKAAELQDGDIVCFQKTTERKGDRNILEKRLGLGDKQAVEELPKKADRFDDAREYYDFLHNKKTVKFHAHPTRCNPEKFPPFELVLNSKISYDVLAERVGDRLGVDPTHIRFWTVNSATGNPKTTVKRGVNQSLQLILNPSGYNQLSSSQRTDAFYFEVLDMSLAELDTKKTVKITWLSEGITKEDHYDLLVAKNGNIEDLIQVLVKKAGIPDEAEGGRIRVYETSSHKFYRELPREYPVISMNDYTNVFAERVPEEEANEEETSNFIQVFHFQNEPSRVHGVPFKFILIEGEKFVDTKKRLEKRTGLKGKSFEKIKFAVVKRSHFSKPQYLNDDDELWNVATSDDDYLGLDHVDRTRTLRNGVGDLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLD9</accession>
    <name>A0A1B7YLD9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161235.1">
        <property type="nucleotide sequence ID" value="XM_018299989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLD9"/>
    <dbReference type="GeneID" id="28864096"/>
    <dbReference type="KEGG" id="chig:CH63R_05014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05014"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="78" mass="8274" checksum="90A40B12E8AA99A4" modified="2016-11-02" version="1">MLPSPRVHIAPPPPPVGSLNPTCSKCTRLPVLILPPDSSSRPPRTTYLDSPSTAPGSLDRAKISPRRFSLLSSSSCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN60</accession>
    <name>A0A1B7YN60_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162022.1">
        <property type="nucleotide sequence ID" value="XM_018297206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN60"/>
    <dbReference type="GeneID" id="28861313"/>
    <dbReference type="KEGG" id="chig:CH63R_02231"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02231"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="240"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="425" mass="47607" checksum="1577F6B72038B522" modified="2016-11-02" version="1">MYAWTLDNLEDRTPSPSPPASRPDHHGSSQRRVYILGVGNLGSLFATSLASLPEPPPVTLVLHRKDLLLAWRENPGIEITRRGSVYKHLNFDVELWSEEPPRIGQAREVTEGRGIRNLIVATKASQALPEVDRVRRYLDENSTIAFAQNGMCKLWPPHGKTYTEYRFRDGSRPSWLACVTTHGVTSLGRFKSVHASEADIKIGPVYLNKSAGKSSVLSDLLSQAPNLNGRSVAQDELWVLQLEKLVVNSVINPLTAILRCKNGELFSETEGSLAELIDALLLEASNVLRALIKDQSTDAILQPVPREAKPTTNADVDRNLLDHRLGLMDRFSQSRLKEMLYDVGFKVRDNTSSMLQDVRAGKQTEINEFNGWLVETAGYLDDNLDITHHQILVDLVRNNYILDREALVNHFPCLKDSKLAAARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP30</accession>
    <name>A0A1B7YP30_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_02364</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162155.1">
        <property type="nucleotide sequence ID" value="XM_018297339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP30"/>
    <dbReference type="GeneID" id="28861446"/>
    <dbReference type="KEGG" id="chig:CH63R_02364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02364"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="28"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="255"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="577"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="765" mass="82743" checksum="52E399E2D245B1C7" modified="2016-11-02" version="1">MPSLDIIDHSPHHPDPSPPIPTASNLILIDNYDSFTWNVYQYLILEGANVTVFRNDKITLAELIDKKPTQLIISPGPGHPTTDSGVSRDAIKHFSGKIPIFGVCMGQQCIFDVYGGEVGSAGEWLHGKTSPLTHDAKGVYAGLRQGLPVTRYHSLAGTRVTLPSCLEVTSWVATEDGSPGIIQGVRHKEYTIEGVQFHPESILTAEGRTILRNFLQLQGGTWEENAQLQKGSATNDGTAKTAASAPTASKKNNILQQIYAHRKASVTAQKLIPSQRPADLQAAYDLNAAPPLVPFVDRLRQTPFDVSLMAEIKRASPSKGVFDININAPTQARKYALAGASVISVLTEPEWFKGSIEDLRAVRQVLNGMPNRPAILRKEFIFEEYQILEARLAGADTVLLIVKMLETELLERLYKYSLSLGMEPLVEVQTAEEMTTALKLGSKAIGVNNRNLESFEVDMNTTSRLRSMVPENTIICALSGINSHKDVILCKNDGVNAVLVGEAIVRAPDTTKFIRELCSGTDAEAESVATHPLFVKICGTRTPEAALEAVKSGADLVGICLVPGAKRCISDETAAAISEAVHSFTPSSTRAPSNVPTKSATDYYTASVARLSSPRPLLAGIFQNQPLDEVLEKQKRFSLDIVQLHGNEPIEWANLIPVPVIRAFKPGNIGIGLRGYHTIPLLDSGAGSGKLIDVSSVKDILAKDAELQVFLAGGLNPDNVLDAVKAVGEFSNRIVGVDVSSGVEDDGKQSLEKIRSFVKNAKSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPT1</accession>
    <name>A0A1B7YPT1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="10" type="ORF">CH63R_02773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162564.1">
        <property type="nucleotide sequence ID" value="XM_018297748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPT1"/>
    <dbReference type="GeneID" id="28861855"/>
    <dbReference type="KEGG" id="chig:CH63R_02773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02773"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="17338" checksum="EB0B0EF59CC850CD" modified="2016-11-02" version="1">MAPLDKPTPAELEQQLKDTIHDLYQIMVQVTTYNATSSNPSGPALSDSVQALSQSLQRVHMTATAGAPPSPDLPGALPKIPPELVQYVENGRNPDIYTREFVELVRRGNQLMKGKMSAFAQFRDVLADHMERGMPELRDDVARVLEGTKVVGSGRPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQC3</accession>
    <name>A0A1B7YQC3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1 nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162762.1">
        <property type="nucleotide sequence ID" value="XM_018297946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQC3"/>
    <dbReference type="GeneID" id="28862053"/>
    <dbReference type="KEGG" id="chig:CH63R_02971"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02971"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="613"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="799" mass="85578" checksum="D813C3724FF23D6B" modified="2016-11-02" version="1">MAANPIEAKPSSRDESSDSGSGSDSENDTPTTTTTTTTPTAVEWLATGRSRRSTAGNRMKSMLANEEPDSDLELLFAEDDNDEGFTDVDDAGSDIQMDSSSDDEDEQNRGDDFEGEKELEKQARERKLASRKRKAEEAIPAKFRKKVRIDQAAAAAAAAPAPRPKKKSERTSWLPSPADMPIRASLRQTTMLSKEQLHQQMKERETKRLKQLAVMEKKAKKLAASKKPPMTQAERLAEAASVEKRNAKSLNRWEEAEKAREEERLAKLAALNNRTLKGPVVTYWSGIGKWENHLKHVGRVAEEEKAPRKKREKKDKGDKAKGKEKDEKEPKKEGSSTAGAASTSLPPSTCPDGQAEAKPGAPLASPAPADPGNPQQSRVPNPPSPTATAPSEATPIVKEEDRPRVMAPPPIPPPPPPAVSSASSRPEGQPRLMAPPSIPPPPALGSSSPMAPPPLPPPPKTSPPVLAAPVLALPVLAPPLGGIHLVQHTTQPKSNVLAPPNTTQHKSPLSMPAPPPPPSARPPPPPLAPLQPTTQPTQPPAPPKPAPPPVAAPSPPPAPAAPPAPEEPPPSEVARNAFILRNFDEELVRDKTVQTQILFGRRMDRLAKPAPRPVCVITAHPARYRDPETGLPYFNAYAYREIQRLRRGEYKWSSLLGAWVGTCTYAARGVPERFLKGGRPKEPNKSKGAGVEPKETEANTVAEATESQEAPNTDKATTPTQEGALEQPPPTGSEGATVPSPSPSVPQTKVQTQTQTQTQTQTQQQPQPLVEAQKQDQGAKPAAAEPAPQPGVASVSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRS5</accession>
    <name>A0A1B7YRS5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_03380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163171.1">
        <property type="nucleotide sequence ID" value="XM_018298355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRS5"/>
    <dbReference type="GeneID" id="28862462"/>
    <dbReference type="KEGG" id="chig:CH63R_03380"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03380"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="230" mass="26158" checksum="2BC721F3DC43705B" modified="2016-11-02" version="1">MTTRGITRDESIYPDPESFNPGRWLQPEYPTYKEPLTRFPNLDGFSQFGFGRRTCQGVPIVDQDLFLTMGGMAWAFNIQRKRNADGTEVPVHWNDYTPLLIAKPAPFEFDAVVRTPEKAELMRSMFEAAKEEEEHEEMMMKMGMPDVDPVDAKKQSAAPMSTKPPPSSLTMNLRQRKEEGEHEKQYREHERDIPGCPGRWATESDIDSGNEKGYVDDDSCSGRSSPTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRW3</accession>
    <name>A0A1B7YRW3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_03420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163211.1">
        <property type="nucleotide sequence ID" value="XM_018298395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRW3"/>
    <dbReference type="GeneID" id="28862502"/>
    <dbReference type="KEGG" id="chig:CH63R_03420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03420"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR14694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="524" mass="59674" checksum="D59CCDBE4B4743D2" modified="2016-11-02" version="1">MPFAMEWSTSLLLFGAASLLYLVAVAVSRVYFGPLVGFPGSKLAALTLWNEFYWDVVKRGTFIWRIEEMHRKYGPIVRINPYELHIVDPDFYDELYSPGHKSDKYRWWTNLAGADGSSFSTVPHDLHRLRRGALNPFFSARSVARLEPLIRSKVDKLSARFSELAKTGEVVRLDAAFMALTMDVICDYAFAHDRRYLDEPDFKLLWKETIIGAFEGGAAGRQFPWMLPVMKRLPLPLVSAMNPCVGHLLRWQAGVRDQVRPILDRTDDDDDDDDDDIPSKQGDPSSRTTVFHALRDSDLPPGEKSLQRLCDEAEILTGAGSETTAQALTRILFYLKHVPDTLRRLRAELDAAMPSGAAEMPPWGELQKLPYLTAVIREGLRLSYGVTTRLPRIAHHDIEYKGYRIPAGTPVSQTPYFILTHPSVFPEPHRFRPERWVEAEAKGRRLDRYLVCFGKGSRQCLGINLAYAEMYLAVAAVVRRFDWDMFETTLDDVVCKHDFFVAVADLDSRGVRVKLSSRDNRRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSF3</accession>
    <name>A0A1B7YSF3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163484.1">
        <property type="nucleotide sequence ID" value="XM_018295122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSF3"/>
    <dbReference type="GeneID" id="28859229"/>
    <dbReference type="KEGG" id="chig:CH63R_00147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00147"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="39046" checksum="65B9770C85371EB2" modified="2016-11-02" version="1">MPAQAIPVNILLIGASGYIGGSVLAHLCSRPNNAGLHISALVRKPADSDAIKSSYPQVETVLGDLGDERLLYDAAAGSDVVIYAARNTQEGVEPLMSGLAGEARNGLESSQEQASRNRPALFIMLSAIISLADPKNLRLGEPPLDSSKAMSDVEDRNAIMSLPEYHWHVAQERVFIRLAAEKGRGIITPVVMSLPFTVGNGTGPVRTRGFVHDYAKALLHRPGKKPFVMGQGRNAWSWSSPRDLAAAVVFVMDWWKGNPNDNDLQGYIYAESGQLEMRKLARYVGQVSGSVSAGQEEEPSTSSDGCESLQYPQFAELMPELPGLWGVSAVCQADKLRSKGWKPMATSWEPLVDEVVRSSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSU9</accession>
    <name>A0A1B7YSU9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163623.1">
        <property type="nucleotide sequence ID" value="XM_018295261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSU9"/>
    <dbReference type="GeneID" id="28859368"/>
    <dbReference type="KEGG" id="chig:CH63R_00286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00286"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="2">
        <location>
            <begin position="789"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1049" mass="116243" checksum="1A4B384E42CCF155" modified="2016-11-02" version="1">MTQVRLPSSTAASPSARTTTSSSPSPTPSFGSTPSFFSSPPPQQLFPSQGSSSSTPPRRFPTPPFGSTPNFVLSTPQDNTFVFGGLLRSTADGPSVTYPDDPLPSVERDWRSPSIATGASSRLDNNARTPSFSFSPPPPSTPTQHRTVTSVVTSPNGTASPRSPDETESVAGRLGNMNLTPRQPSLAMSDVGAAIADVANGLDEQTPRPAASSPDFGRPSPSPSPSPHPRLKAKKLPHNVKDEKPPSNRFHDPTVQQAFGEAKTLMSSLANALGSSSLHVNPDSTIQRLHRQAQDLSRFQCPSTRTVGFVGDSGVDNQHLARTSNSGAACTCVVTEYHYHDSRDFVIDVELFSQEKLMDQITELLQTYRRHHLPSEENETAVGADVREVEDVGEVKDVEEQAKVAHDTFKAMFRDRLKDEQVLTTKPKDYVLSTLRSWVLEARPSQIGGIKTRSSLQECSDLLMHLTSETAEATEPAVWPYIRKIKVFLDSHILSKGLVLVDLPGLRDLNSARRMITERYLVECDEIFAVCNIGRAMTDVGVFSVFELAQKAKLSNVGIICTRSDDIQASEAVRDWTGSSAERVQKLSNNVSTVQSEISNIVLVLPDEDTGEDSDCYNKLFRDKHKAEKRLLQHQFKLKKYLIETRNTDIISKLQTQYGDAVPARTLQVFCVSNTEYWAKRSMPRDDALPSLELSCILDLRKHCLSIVADTQLEAAKQFVVNDIPALVGDVALWVQSGAGSTDAEHKRAVRETLDEVERRLKKYVLSYLSLPHSPHALGSDRWRLSDRNTDDWTQSAIAAGSKWNEWTHPTYSAFCRNYGCHYTKAVGRWHDWNEEIIAGMVTDLAVPWQRLCSSFGDEIEQAIDLVDESMEWALEFLEDELDGFSFTMTLSQVLLCHKNTMLAEAQKAYDNFENSLSTLRVDALSGIRTSLIGQAMESSYKACNLDSGGGSHERRKGYINGTIARQDLFRNLMRDFRRRLNGLADSLQADLLTTIRAHLAMIDETLDLIRRENVATESEGNPELRSRLGEEVSLATEKTRLIQQVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSY8</accession>
    <name>A0A1B7YSY8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163682.1">
        <property type="nucleotide sequence ID" value="XM_018295320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSY8"/>
    <dbReference type="GeneID" id="28859427"/>
    <dbReference type="KEGG" id="chig:CH63R_00345"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00345"/>
    <dbReference type="OrthoDB" id="4849945at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="380" mass="43742" checksum="46A571AAEEA90B96" modified="2016-11-02" version="1">MKDDQDRRRERPDRRIPMEFNIFDSGIAEIVDKPLFCLSNDDEPSENHVGINLHAGPFDLHPKIANLTHRTVVRPGWETIKTMEVVLFEAQEMKGAEKVVLEQQRPTGGIWDLFGRLLWWRASAIRWVFTMQIPLQERLLDVDFEWRHSRGIKIRRLRGADGWMLWRKRTPDEVRKMVNDGDELMALVSRGARSDLGTRFEFANSAARGDWGDGFSVVALMSGIGVILAEKKSLGDCVDALEMTARRRSMLMRAALAEKQARDARDWLDTMELMEEQKAEELSRPRSSQFDRVRTWREQQASNKSGSFGTPRLDQGISGVRREIRLPSNTRRSATTPRPLSTTTRNTALTSGRRTASNRSRRYEQESDRFVRSQGCPQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT21</accession>
    <name>A0A1B7YT21_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163713.1">
        <property type="nucleotide sequence ID" value="XM_018295351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT21"/>
    <dbReference type="GeneID" id="28859458"/>
    <dbReference type="KEGG" id="chig:CH63R_00376"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00376"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64563" checksum="EFF87888B946C2A7" modified="2016-11-02" version="1">MMTQASARFLFNPSPLFNFSSLWAAALGVSLFLLFANTPLHSLPRDTFRMLMMNARSRSKLADDVSEGAEGLSPSSTANLVPVRFLIVGLGPFAKRSYVPRLLSLTAARRAALVAAVDVEDNRRDLEQYRRATCPDAEFVFVPHFTTEMPRDISSMLTRLVERLQVSCVIISTEPLAHCAYGLWALGLGLNIVMDKPVSTRHSAVSSLDQATGIAQDFDKLVQSYHSLQLRKSTCFLINSHRRYHAGFQRATQLVRRVSEDTGCPVTSIYTLHCDGQWRLPSEIVQQDYHTYNRGYGKVSHSGYHSIDCVYLFMRAGMGDKKRPDRVEVVSSFVQPAGFFFQLNEDDYKNLFGEQAYDAASTFTTKELLCRTKDFGEIDASIQLTFYNDNEPVSLVHLDLQHTGFGRRTWLEPGKDLYKGNGRVRHEMHEIKSGPFQSVVIESRQSSDRHDVVRQNHAELGGNGHFDLKLFQNSGMLGHRDPLRVSRLDELVRDKMGDAVHGNDYSRFVKYAALDEALEFMEGKKSVRDLISNLPDHHVPAYLMSAMYASHIRRKHGLNPVVSLDLSFDRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTM4</accession>
    <name>A0A1B7YTM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163916.1">
        <property type="nucleotide sequence ID" value="XM_018295554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTM4"/>
    <dbReference type="GeneID" id="28859661"/>
    <dbReference type="KEGG" id="chig:CH63R_00579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00579"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="45647" checksum="29999A769A012B7B" modified="2016-11-02" version="1">MPPPPPPPPPPMPAMGGPPPPPPPPGGPPGAGALPARPPGGANRGALLTDITKGKALRKAVTNDRSAPIVGQSSGGPGGPPVGGAPPIPGLGGLPKPPGGLAPPVPGNRARSNSDQSGRESTPAPPMEAAPQLGGLFAGGMPKLRKTRGAVDTGASADSSYLSDPESNVRSSSAPKPPTFGAPKPPGGAAPAPPGRPPLPPPTAAPALPPSIANLRKTTSDVPRPGSSASMKGPPPPIGKKPPPLPASRKPSSTPSSHPPPVPGAPAPGAPPPPPPSNAPAPPPPAPPSAPPSAPPSAPPPPPAAVAPRAPAPSPPSRSPAPPPPPPASNGSSPLAMQAALRAAGQASPSAAPPPPPSNAPSPPAAAPPPPAAPPSRARAGSGLRSSMLDPSAFTLAPNGAKSPSPTRSSTTASLHAGGGGGGGGGQRYIVQDPRWKFQDEAMLPKPRDFVGGPRRYRAGRGSSVPLDLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTN8</accession>
    <name>A0A1B7YTN8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_00590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163927.1">
        <property type="nucleotide sequence ID" value="XM_018295565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTN8"/>
    <dbReference type="GeneID" id="28859672"/>
    <dbReference type="KEGG" id="chig:CH63R_00590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00590"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="12">
        <location>
            <begin position="479"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Bromodomain associated" evidence="13">
        <location>
            <begin position="682"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="878"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="962" mass="106286" checksum="4B7483D3F0BB51CC" modified="2016-11-02" version="1">MMTIQASKFTPEVLLSAPRRSPGIPNPAGTKVLYTVSAYSFDSHRKTSQTRVLDVESGHSALLYEEASYGDATWISDREILLLRTGDKGTTSLLLGDITKPSVVTEIRHFEGSLSSLKVKRLSDDEVAIAVCVLTTPEGSMYNPAAEKKQHTTGKIYSSLFVRHWDTWISENQNSIWYGLLRKDDKTYKLEHPGLVNALEGSKLQSPVPPFGGAGDFDIGKNGIVFVARDPEISPAIYTKTDLYFVPLKAFTETKPPVPQLVKTSKLRGYSAAPVFSRDGEKVVFTRMKSDQYETDKPRLMLVPNVFDLASVQEFYQTDDGAGGWDARPEWITWSKDDSELYVSAEEHGRAKLWKLPSSPHEAIDLPAAVYEEGSVIEAKLLGDDGDKLFLSTSSRVENSAYWVLDPASKKTDLVSSSSKHGKSFGLSSSQCDEFWFKGAEGYDVHALVVKPSDFDENKKYPLAFLIHGGPQAAWMDSWSTRWNPAIFAEQGYIAVMPNPTGSTGYGQQHTDNIQNEWGGRPYVDLVKCFDHIEKNIPYIDSGNAVALGASYGGYMINWIQGHELGRKFKALVCHDGVFSTLNQWSTEELFFPLHDFGGPLWENREGYEKWDPAHHLDQWSTPQLVIHNELDYRLPISEGLAMFNVLQARGVPSKLLMFPDENHIKRNTDTYIRTMTPPPLLYHALLRPVVLQILRTTGYHASRPVVLDALTELAARYMYALCQATARHAADNNPEGEAPGIVDVRMALQELGAVPPDDVLADGRGAILGEIMDSIERGVRSGEAATMGDEPDGEEDLAMTTALAEVARERERVEDTRGVEEFTKWFSGPRNKSIREAAVGDGELEMGDYLNGSFIPLPTTLLAGPYLTEALVLKKKHSKTGEDSKYHGTIIGKGNDVGEVQVEGGDLPSIHTWRTKMQGPLSGSAPSATSPRIKEESRPPSSGLSSVGDRLGDDRDGMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUL8</accession>
    <name>A0A1B7YUL8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164230.1">
        <property type="nucleotide sequence ID" value="XM_018295868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUL8"/>
    <dbReference type="GeneID" id="28859975"/>
    <dbReference type="KEGG" id="chig:CH63R_00893"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00893"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="722"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="845" mass="96816" checksum="5C4B276D2573466B" modified="2016-11-02" version="1">MMDAFVQRLPRPRPPTPSRSPSRPSPLGERPAKKVKVEIQDSDCEDDECDVKLAEEDADTSGITVNDVSDEEGKGSLSTRQTDIESTLPPIHADKEAIEEYELMKSSQAGAPDDEEKPVTANRQWVRGKSSIYVDAFNLALETVLADESHLFDAKERTVFEQWESLDYEAQYLYVRLFLRKTSAWHRQDRLGYYSDISDPEAAIESLQKPRDLPEVEASKESNPVEGIELEEFSLGDTFTFADASEEHITTIEEAASLLSLDELKDLAKEAKFQGRNKADLVKALCRTGYQQTGLFAHGLHRSGSGESQTARGLMRHGHDTPPPLNRQESNQTQHFLDKIRDITGPCIRLSPLTYKLFERVHLVFYRSTEWTEKSLTAIILASIARRNYPEYIVCRSTNIFVTRKHVLEFESALRVEAEVDQILEFNGSPGEAGFRKVVDIFNRVYPRWKVLLAEEQEKEKRVYEEGEGAYLRRFTPVHSYTRIVHKAAAVFGRLKDHEREHATLTELLDQHLFHPARRGSWYQRKALLEEHYMHALDGNAVSVDPDVQKKHWKRIAATTCETGLEDKDCHLIYHYDLQKRLVKLEKQLRIPRRLQHDFGHVRLQKPVEHTVEGIQLKRDDRQGKNGRQASTKTIWVDELEAGGECSVEEMCLSWYRGQGYKGYHAEGGIVRTLFAYLFYDILFLYIPNVFQTAYQTCPLDLHTDSFYPTRMSEINHRLVDIANGGAERIIRKIDTRERERRTCVIGLNWDYDIEDLVELVGCFNGGALAALCKVMAQEYRQRGGGLPDLILWRTEPEKECMFAEVKSANDRLSDTQRLWIHVLTGAGVKVVLCNAVAKEVREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVU0</accession>
    <name>A0A1B7YVU0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164505.1">
        <property type="nucleotide sequence ID" value="XM_018296143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVU0"/>
    <dbReference type="GeneID" id="28860250"/>
    <dbReference type="KEGG" id="chig:CH63R_01168"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01168"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="281" mass="30243" checksum="38F09E6478FDAD1E" modified="2016-11-02" version="1">MAETNPKVLSNSTLYEDIVLRRTVCTSYNVGTTRLVFTIDRPLSCSYAAQSLTQDPGTWAPTQSVLFVQDRSRYFVRSPSRLTPRSPSSPSPLASSGLSVADSRQIDPTTSTRRPTPHHLHFLPASALSTSVTSPPSPAAATAIFEPAVSSDECNTTQDSPDQDERTGSIRQPTNQPTAWPSLNKASPDEQREGRLCSGLPGTYSNSSCRLNVMSIPPSRLCLSSRANIVASQPPSSSLPFITSTPPGLVAVPLPPSPPPCFIGTQTTRQPPFDEDEPKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW11</accession>
    <name>A0A1B7YW11_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_01407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164744.1">
        <property type="nucleotide sequence ID" value="XM_018296382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW11"/>
    <dbReference type="GeneID" id="28860489"/>
    <dbReference type="KEGG" id="chig:CH63R_01407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01407"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF13">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="353"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="682"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR16227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="801" mass="89747" checksum="269CED234760B3FB" modified="2016-11-02" version="1">MLSNNPPTSNLHARHRAHRRQNSTPTAFDAVKIQPLPQNVQRQRALGHRRGLSLDTRRQDFATHVLREAQQQRIQARPGPRQQAHLRQHSQQQIHQHQQMFMAAGDHENYLVSPHGTPHAQRFDASGFDSSPIQYNQYGSQMNGVVAKNQQPFTGTMGGGSKDFELFASDSALSTPSFMNFGDTPGTPQGWISEGETASTRRSSRRISNGIMDRVAKFETMGMEMQRPMTPPHQDATNYFPPTPMETPHDRAVKHEPMSTRPTRFAEGYDESMEETLKPVRRTNQRAQNIFEDLRRQSEQNVVPGSQEASQIPDGVYDHVVPTPDFMNMNNFNNEFLKIQGGYEGLSDDVQVHSDMSQQSTPHTPLMNFHSVFDNRPDLHHPNMTIGSVSPSRSFDDRSYDDRSFDDSRRSSPHRRTESLASIASAASIASINIEETKTETGVTLDEIAMYISGPDPIDSKWTCVYEDCGKKFGRKENIKSHVQTHLNDRQYQCPTCKKCFVRQHDLKRHAKIHTGIKPYPCECGNSFARHDALTRHRQRGMCIGAFDGIVKKVVKRGRPRKHRPEMDERVNKSARTRTKNQSTASTSSQSGYSDSSAANSPENDYNMMSDDQFGMGGISIERRGIDMPLQITTVSSAPMPSSPPRVHRELRELHLQSSPAASHNSGYVSPEALMEAPISLPQQPESPAKSEYNTPPELSQSSSPPPNQFFDAEPNHSGFSDDSLLAGMRGNPGTVGNTSISTLGLGEADDELLMKAFTTEEGMVQFDRDPSMLMMSKFDEEFDDAVNMFTNNDDVFFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWD7</accession>
    <name>A0A1B7YWD7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164789.1">
        <property type="nucleotide sequence ID" value="XM_018296427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWD7"/>
    <dbReference type="GeneID" id="28860534"/>
    <dbReference type="KEGG" id="chig:CH63R_01452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01452"/>
    <dbReference type="OrthoDB" id="5419219at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="892" mass="99884" checksum="5748E600CCDBC908" modified="2016-11-02" version="1">MTDDHGRENPSKELRTGNVAEETCSVANHLQYHHINTLTFTSLPSALETMAGPSRRRRHHVDSSSSESIAAHSPESGVKPAKHHRSRNLTVSRVMRFCLPRPTDRRSRTTNRLPLFGNLRPYAGDNASWLQERLWELEVRRFIQVVNGTEDMLVPVLKLDSDEIIHYSLTRQNSKKLQVLADRIRAALHVCVIDDSLLLERLPDNTRPSKRFSESYWALRQAWGEEDDLPGRRQRSDPDDISYQEYKAKRRGDTAEDQHRNLDDFELEQCYYLVDQVTATLVLLAVRGRDNDYWLVVVLACLAKLSTKIKFLVREFSKNVAICFRNSKDHQDTLGPEHFRDDDAQQPLNDNSPTHTRYRREVEVVSGWLTDCFIRVLRGLGAQNPRSARSGSVDICTIVYPAGIAGTRTLLCQARNGEVSGSPGLIPVAFASNSITIIDKLSSILSSRAHIPPPGDQATDETMSDRSKSASKGSDEPETVLVVELERHNEDVDGEQRFNHVRRRLTIRTLFDFVAIATCLSLCHPEVGIGFQSSLQTISALSAFEEPEDHEYASTKSAAPTRSDVPTEHTPSTKSGTAFYAFVNLWADNAEGGRPTDTLSSLSNSVIAARRHNVLDRQLPPLNHARVGTSATRNPREVIAALNEAQEKRKRLENIIRKWKIHESSIVVECPDFVVRVSLFSAALVLGGLACGFFVGERITGVDPFNLTMFSWIIAGFVILIAKSVRVSDWTWRDFLFRQVTCRTVKEVADVVPGLDEQDILCFLLSSEIRSTLKTRGPFGGVFYFSPTDGGFSIDVKPNLQTLWAAGVIPVMVQTLEGPVLRFLRLVSGYNGHTSVEMSGQCVDCVCKNPPDNAFDVTSPEEGQIDEAVVLFERISWMKILGVYNVTGVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWE8</accession>
    <name>A0A1B7YWE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164883.1">
        <property type="nucleotide sequence ID" value="XM_018296521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWE8"/>
    <dbReference type="GeneID" id="28860628"/>
    <dbReference type="KEGG" id="chig:CH63R_01546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01546"/>
    <dbReference type="OrthoDB" id="4622520at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="72" mass="8479" checksum="19B9162CD493B387" modified="2016-11-02" version="1">MTWDHRNEEKLVVPARQVDPQKLSVLLKQKFGEMGLSYRVEMRHNSYRIYAQRPLSPQMSIALLLLDGAHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWX6</accession>
    <name>A0A1B7YWX6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_01733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165070.1">
        <property type="nucleotide sequence ID" value="XM_018296708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWX6"/>
    <dbReference type="GeneID" id="28860815"/>
    <dbReference type="KEGG" id="chig:CH63R_01733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01733"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="158"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="511"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="842" mass="93153" checksum="863A59BF37919C3F" modified="2016-11-02" version="1">MGKLLSLGPRLHYPITITKLLKNPGEAIKKQESILEYSYKSMREFGDPIAGDTWQEEVTTIAGWDSPAEGTLKEWRLKEGTTVTRDAPCMMVDEACSHEVQFQGLCAICGKDMTEVNWASDQRDTQRATINMTHDQTGLMVSGDLAARAEHETQKRLLRQRKLSLVVDLDQTIIHACIEPTVGEWMEDPSNPNYEAVKDVKKFQLNDEGPRGMVTSGCWYYIKMRPGLAEFLERVAELYELHVYTMGTRAYALNIAKIVDPQQKLFGNRVISRDENGSMISKSLQRLFPVNTNMVVIIDDRADVWPSNRPNLIKVVPYDFFKGIGDINSSFLPKRQDILPAPSDSESKPAPEAPSEAPKSAEAKPEESQQNGKVSALDELVKMSSGDDKVLQAAQTGEQEKLLEQQIKERPLLHMQEELDKQDEQKEKETLDAEDGPHIMTVQHRSQVLRDNDTELTYLQQHLTELHQKFYEEYDEKRASAPAQSAPRRRPADENIDLDAVPDVGFVLDTMKASTLQGTTIVLSGLVPLGVDVLQSEIGIQAMSFGAQISTRVSKNVTHLVISTSRPRTQKVRQAAKIPSIKIVSQNWLSDCLSKWEHVDETPYLVEVHPADRRYHAAAAAAAASETTDADTVSDVDGDDLSRPHLTIIDETGEHRILEEDDDASDEDDGDQDGDDDNLMPDFEDGQTSPIDDLKTFDWEGVDDEMKEFLGSDDGISDTDTESRSGDTEAGDEPPSSQESVTGGGTKRKAMDDDTASDEGGSALSKKQRVAKSRGASKLSSVRTPNAEDQESSSLPTPQITGDEEDISRARDDGAVVDGGDDFDEDDLEADLEAELAAAGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UUY9</accession>
    <name>H1UUY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_04341</name>
        <name evidence="7" type="ORF">CH63R_05408</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CACQ02000110">
        <property type="protein sequence ID" value="CCF31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158233.1">
        <property type="nucleotide sequence ID" value="XM_018300383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UUY9"/>
    <dbReference type="GeneID" id="28864490"/>
    <dbReference type="KEGG" id="chig:CH63R_05408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05408"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032067_2_0_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF31790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="490" mass="54988" checksum="1575AB7BB5B2D8D2" modified="2012-03-21" version="1">MAEELDILILGAGISGVNAAYRVRNELPGCTFAVLEARDMVGGTWSYWKYPGFRSDSNMTNFGFAWHPWPHDKKIIEGAPIAAYIEDAVKTHHIDEHVRLRHKVLSSNWDSDEARWTLDCATPRGIKQFKAKYLFVCSGYYSYDKALDTQIPGIENFEGKTIHPQWWPEDLDYAGKRVVIIGSGATTMTLFPNIAKTASFTTILQRSPSYVFALAAESSVDKAAKKILPLFLANWFILLKDLALETVFIQFVLNFPALAKQFFRADAQRQLPKDYPVDIHFNPKYNPFEQRLNMCPDGDVFKTLHQQNTEIVTDHIETVTKDGILTKSGRHLPADIIITATGLHVQLFGGTDVTVDGVPVKVGDKYSWRGCMLDGVPNAAAIIGYVTQTWTPGADTVTRLFIRVIKEMRKTGAVSATPVLSEEEKKSSPRLPCVDATSNYFKRAHGRMPVVTNQGPWYGRKNLIVDKLALWFGSVRVGMDYRMATKSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYV0</accession>
    <name>H1UYV0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_00923</name>
        <name evidence="13" type="ORF">CH63R_06050</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">IMI 349063</strain>
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        <property type="entry name" value="zf-C3HC4_5"/>
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    <gene>
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        <name evidence="2" type="ORF">CH63R_10087</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000720">
        <property type="protein sequence ID" value="CCF33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR05967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10087"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000007174">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="260" mass="29359" checksum="DDA0FC6AF7CC23FD" modified="2012-03-21" version="1">MSFNDSGSEYSYYSYSSAGYAQRDVDGSAPRYASSIHSYAASSSASQASGHSSGSGSQRYYTHTPVTGFSYDEYRMPQTYSDTPPPSTHTALSTFHRGVQQQQTAALPSRRMLHCEFQPWTGCQQQFRLDDVGAWIRHAEDEHLQRMFPTECICWFCDDIVFSTQRCSDAGLNFTQRMEHIAGHIMDGDHFEHRRPDFHYLDHVYRVGKISRQAFELARGASEGPRTSGVLHPAGWRPASREAAIVVTGGGRRRPRERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZL7</accession>
    <name>H1UZL7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Circumsporozoite protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05616</name>
        <name evidence="5" type="ORF">CH63R_06182</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000750">
        <property type="protein sequence ID" value="CCF33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159007.1">
        <property type="nucleotide sequence ID" value="XM_018301157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZL7"/>
    <dbReference type="STRING" id="759273.H1UZL7"/>
    <dbReference type="GeneID" id="28865264"/>
    <dbReference type="KEGG" id="chig:CH63R_06182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06182"/>
    <dbReference type="eggNOG" id="ENOG502QUVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038962_0_0_1"/>
    <dbReference type="OrthoDB" id="2141239at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497548" description="Circumsporozoite protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="39336" checksum="1CBA041B3E8EEE43" modified="2012-03-21" version="1">MSYSKILLISALLVFAEARFGQEQTPVAAVSSLQAGAPGEAATLAGGIPGSLLAAANPCAKLELADKIAALGTGDDVLKAAKGVVAAEQNFNPFATDKPNICGDPSLPATEALRGIVPLVDPAVTGSDKENANSAASLTKPFDATGMSVAQVMMAQGFSNFTVNGQAAGGAAGGAAGGKAGGNAGGNAGGNNNNNNNNNNNNNNNNNNSNSSDANAGNKNQNSNNNNNANADDNAADDGCGGAAGGNTGNADTQNNNNSNNNAGNANANTGNANTGNANTGNANTGNNNAGNNNAGNANAGGAADFGKCKPTIDFQLGRAGRKATEGTFLPSDPLVAQGQQDALNPNIIINRVCDQLTNVCEANDAAKKQCKDAQAQIQASGDRSAAVADTFNGLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1J3</accession>
    <name>H1V1J3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_06165</name>
        <name evidence="7" type="ORF">CH63R_03106</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001011">
        <property type="protein sequence ID" value="CCF34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162897.1">
        <property type="nucleotide sequence ID" value="XM_018298081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1J3"/>
    <dbReference type="STRING" id="759273.H1V1J3"/>
    <dbReference type="GeneID" id="28862188"/>
    <dbReference type="KEGG" id="chig:CH63R_03106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03106"/>
    <dbReference type="eggNOG" id="ENOG502SM17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_6_1_1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
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        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
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        <location>
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        <location>
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        <location>
            <begin position="139"/>
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        <location>
            <begin position="173"/>
            <end position="195"/>
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        <location>
            <begin position="216"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR14380.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="308" mass="33825" checksum="598AF0D77C29E674" modified="2012-03-21" version="1">MSGPPPPLPSNLVFFGPSANCTLDLCPIEYSLYKYRPNLAVNALFLALFALAGAVHVYLGVRWRSWWFMAFMLAGCLSEIVGYVGRIIMYNNPFEFVAFMLQIVFITSGPVYYTAAIYVTISKTIESFAPELSRIPTKVIYWLFISFDLFCLVLQAAGGALSTTSRGSSDVGIDLAMAGLVIQVVVLVAFCTLFADYMFRYTRSTAARRLTRREKVFFGFLALAIVLILARCAYRVDELSEGYSDSDKITDEGLFIGLEGVLIICAVFALCIGHPGLVFGKNKATDGERKGSTVESGVESGIAVTERK</sequence>
</entry>
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    <accession>H1V2B7</accession>
    <name>H1V2B7_COLHI</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="6" type="ORF">CH63R_09538</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001116">
        <property type="protein sequence ID" value="CCF34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156535.1">
        <property type="nucleotide sequence ID" value="XM_018304512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2B7"/>
    <dbReference type="GeneID" id="28868619"/>
    <dbReference type="KEGG" id="chig:CH63R_09538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09538"/>
    <dbReference type="HOGENOM" id="CLU_042941_2_2_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="29033" checksum="B3D26DA0F5556E4E" modified="2012-03-21" version="1">MLDTSVSDDGRRSSSEDRPVDGYDTDAKETDLDQPLITNAPERRRRDKRYRRLPACLTVPWPFCVHLLLGVANIAFLLYTTRYLGVASPKPPYSPANDAASHFVLKQFEGVVEGTVTPYNGPPGQEVDKAWEELLRTAMFWITKDELEAAFGAGYNGFPIPGSDGLMCHADPTLYSIHWYTNRCGDKPDLSTMHVCRDWDALHGWARSRALDNMTLFPGHPLYGNGSCGVDGGPQEELKFRFAKDGRGVEIVGYDKTADGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4T1</accession>
    <name>H1V4T1_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_07064</name>
        <name evidence="5" type="ORF">CH63R_10530</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001455">
        <property type="protein sequence ID" value="CCF35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154928.1">
        <property type="nucleotide sequence ID" value="XM_018305504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4T1"/>
    <dbReference type="STRING" id="759273.H1V4T1"/>
    <dbReference type="GeneID" id="28869611"/>
    <dbReference type="KEGG" id="chig:CH63R_10530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10530"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_9_1_1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF13">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE OMEGA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR06410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="280" mass="32387" checksum="FA77256F94FDB67A" modified="2012-03-21" version="1">MANVDTSIGARTTGAAARFAAEHSEEHPLKLYGGWFCPFVQRSWIVLHEKQIPHQYVEINPYKKDPEFLKMNSRGLVPTLAVPVDVKGNEQRPLYDSTVVSEYLNEAYSGNNYGPHLLPEAPYDRARCRLWIDHINSRIVPGFYKFIQHTPEKEYSIDQARDEFLGNIKTFTKEMDPEGPWFLGKTFSLVDVMLAPWAMRLFLFDHYKPGGLGIPTESENEDDEKTWKRWRQWYDAIQEKQSVKSTLSDKDAYIEVYKRYAEDKTNSKVGQATRSGKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V633</accession>
    <name>H1V633_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_01355</name>
        <name evidence="9" type="ORF">CH63R_01250</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001646">
        <property type="protein sequence ID" value="CCF35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164587.1">
        <property type="nucleotide sequence ID" value="XM_018296225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V633"/>
    <dbReference type="STRING" id="759273.H1V633"/>
    <dbReference type="GeneID" id="28860332"/>
    <dbReference type="KEGG" id="chig:CH63R_01250"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01250"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_0_1_1"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="212"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="455" mass="51318" checksum="AB5BD6B86D65D45C" modified="2012-03-21" version="1">MRDFASFLQGKPTLPSLWTGNINFAKLNPIPHRYRPSRAKRNQKKRDTYNGAEDVTSLQRSFNPLVTLRKLQNHKWRLLDLQYTILIALIIFSLCITPSAPLIKTLAVAGGLLLLTVPATSQFFFPGLSIWTYLIYFFCSRFIDAKYRPHIWVRVLPALENVLYGANLSNILSAHTHPVLDILAWIPYGLGHFGAPFICAGFLFFFAAPKTVPVFAKCFGWLNVLGVTIQLVFPCTPPWYENEHGLAPAAYGMQGSPAGLARIDAILGIDMYTTSFTTAPVPFGAFPSLHAADAVMEALILSYCFPRFRPLFMIYVGWIWWATMYLNHHYAVDLVGGSLLSAGIFYFAKARYLPQQQADKKTRWEYDYVEIGEQTKTFDEEYGRMYNMGYLRRRGSSSSDEWAVGSSSSYSASSRGSGSLSPALSEESGRSIFSIEIRPDHERYEIPQLTEVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V678</accession>
    <name>H1V678_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07449</name>
        <name evidence="8" type="ORF">CH63R_11989</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001669">
        <property type="protein sequence ID" value="CCF35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153804.1">
        <property type="nucleotide sequence ID" value="XM_018306963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V678"/>
    <dbReference type="STRING" id="759273.H1V678"/>
    <dbReference type="GeneID" id="28871070"/>
    <dbReference type="KEGG" id="chig:CH63R_11989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11989"/>
    <dbReference type="eggNOG" id="ENOG502S1X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015361_2_0_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="666" mass="71620" checksum="9204DDF7E2945BED" modified="2012-03-21" version="1">MNGGSAKGVKFVGSDASGLPLKRKQVQQACESCRKKKKRCIHAEVAPVELAHANAHDGPAGSSPAKDVHLVSSTGSPTKHRNSTAAPDDGALSKSPSRRESATAGQPDHAQTPQTRFVGDLNPEGMFTEAADPAAAADPIQKAEVGVWLPSVNATSAQSTASVVSRPPAMIDKVLLPFVKETCLKCVPPEKDFRHLHRVYREKIHPIFALVPEDVLDDGDSPAAIVMRQVVSLAAAADPEMKSHLRLANHGNKKLSYQDFSQMLSGSVQTILETSLISDRTVHIRALCMLSLYVQPSSADEADLPARLGARAAHHSQTLGLHLFHSSDDTLDTLFCAVWALDRINAASYGRPCVLHEGDIGPGLDDCFRRQAPCLRLFLSVVQWLDKVIELYRPGVIAQSLESKPFIDLPVLEPMILEAEALQVSTPLLATIEVFYHAVIILSCRLSRPGPPAQYASSIPPASANARRSLAAERISSAIRRDHLSPVPLVPYALSLALSVEYRKMRHSALPMFRARARSAFKSNSELMKRFGDVYWSARVVAGLGERILREMERAANSIAQGAAGPLATSSITDVPTTARTEEVASVAAAPDAVSQAAAVPAVTASTTDFPPLDAIDFSAVDAMPHLDVFGHFDPSFNLPAVDNALEANLDIGLPLNWGEWDHFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9W6</accession>
    <name>H1V9W6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08451</name>
        <name evidence="4" type="ORF">CH63R_08804</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002264">
        <property type="protein sequence ID" value="CCF37019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155801.1">
        <property type="nucleotide sequence ID" value="XM_018303778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9W6"/>
    <dbReference type="STRING" id="759273.H1V9W6"/>
    <dbReference type="GeneID" id="28867885"/>
    <dbReference type="KEGG" id="chig:CH63R_08804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08804"/>
    <dbReference type="eggNOG" id="KOG1255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_1_1_1"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF37019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="236" mass="24523" checksum="DA692654976522C2" modified="2012-03-21" version="1">MKVVKPHASAVFVPAPFAAGAIIEAIEAEVPLVVSVAEHVPLHDMARVQEILRTQSKTRLVGPNCPGIIAPDQCRIGIMPYKQYSKGVVGIVSKSGTLSYEAVGATTKAGLGQSIVVGMGGDMMPGTTLLDGLKLFFGDDETKGVIVIGEIGGEAELRAAEAIKAYRKATPIPKPIIAMVAGRTAPRGKTMGHAGALLSSRDVPADDKAKALEEAGAVVVPHPGVMGTEMKRLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9X3</accession>
    <name>H1V9X3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 chromatin remodeling complex Ies1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01618</name>
        <name evidence="3" type="ORF">CH63R_04145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002268">
        <property type="protein sequence ID" value="CCF37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160366.1">
        <property type="nucleotide sequence ID" value="XM_018299120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9X3"/>
    <dbReference type="STRING" id="759273.H1V9X3"/>
    <dbReference type="GeneID" id="28863227"/>
    <dbReference type="KEGG" id="chig:CH63R_04145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04145"/>
    <dbReference type="eggNOG" id="ENOG502QVDM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007606_1_2_1"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="677" mass="74753" checksum="B6CE0F38E75F3196" modified="2012-03-21" version="1">MSPDSPSSPAGNAVSDAEAPTSPVRGDEGKSFLSQAMTEDDDTRMMDGTPEPTEKTSGRGKGKNAAKESSSNITGKIRHLKKEDGEPLWRKDIQYDFLKAIFDDETAVFTNSYEPERPRQNFADLYIDTMSRSSKTSKVLRDKLLSDRSAAKGMAMVCLLVNIGRMNTTLNFFPEMRAQLRTYHAIPSLQAHQDAHAYKQLQDAPRLKSILKGGAEDREEPGSLNKIKARDVPRTNPVNLLFVICQSAAKIAELHFPPGREFHDLVMKTNYTSISRAKAFLWIMWFYLESDFTEEGCDENPFGPGVDYGVDVANQGVPELIEMTTEDEAAENVDTEVEIKFGEEKQKMRAKILEADQAYLADNQTKRGSRTSRVMAEDGPAILPRIRPSKHESDMDSVRSTPPPKALARGLGGSVRRGGAPLKYQIFEASSPAGPAHGSAEGIVARKPRPPTAHQIAVERNRNQRVEYILDRGYRKELHKAKKKRQQGSTLYRAFMRIKQIDNPFEDSDPEDDPRQQLSNNDGNSGPFRQKGLGGIAPLASENDDFGEEANAYTAALRRTSRRLKRWGAHEGPPLGVIPPRKRKKANGETNGNDEAGDMTMDLDTLRASEARDGSQARANGDVNGDETLGDITMGDITMDDGDDADKTAAADDDEELDEMDRSLLGLAAEDSASEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9X7</accession>
    <name>H1V9X7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08459</name>
        <name evidence="4" type="ORF">CH63R_11464</name>
    </gene>
    <organism evidence="3 5">
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
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                <person name="Arachchi H.M."/>
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                <person name="Hansen M."/>
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            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
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                <person name="Howard R.J."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="331" mass="37172" checksum="0A65CFF3D36895C9" modified="2012-03-21" version="1">MTYFHLLLWLVIFSWSSTAQLRRRDPGLAEYIIYPKEEAAKGDLDVFHQTLEKLAGISNIETIIDDGGDSPFSWRASLTSEQLNEVENHPVVFATQVNKPTVFNPDPELDTNLRHSSIKPSRAKRATVSRTPIADNDMLDLRMASTPPGQDLVENYVSEDSAGAGITVYILEFDAVMFHKELFPPYSSVTRRQIDADESLLTNERRKKSLTQHGTCVATKVAGKTTGPASQANLVLVRPGLETFSVFKAYESIRDDIKKNRLQGKAIITTSIQLFPEKGATKQQIKSLFSTHRRLVGQIIKLDVPINMFDDTHKVLRSVEFEENGSKPHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBY0</accession>
    <name>H1VBY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08995</name>
        <name evidence="3" type="ORF">CH63R_00212</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002607">
        <property type="protein sequence ID" value="CCF37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163549.1">
        <property type="nucleotide sequence ID" value="XM_018295187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBY0"/>
    <dbReference type="GeneID" id="28859294"/>
    <dbReference type="KEGG" id="chig:CH63R_00212"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00212"/>
    <dbReference type="eggNOG" id="ENOG502T7II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093906_0_0_1"/>
    <dbReference type="OrthoDB" id="5222624at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="180" mass="20928" checksum="4D528917047E49E2" modified="2012-03-21" version="1">MSVALFYVFDRKKNAQFREACRRDPYLTRKEFARRRKLSSIERLEEEEMQRSIMIRKSLASREPSRQNSCEDFDVVSRLQQQQHQHHQEHEEKHRLGRQLSEEWMARTRSGSETSSSASSARDHHPYVEPHPGVEVEVPLAPHPRTPSPSRTPLVRKPVPPPPAVASMAEVSRPRPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H1VC60</accession>
    <name>H1VC60_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_09056</name>
        <name evidence="16" type="ORF">CH63R_00109</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02002647">
        <property type="protein sequence ID" value="CCF37813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163446.1">
        <property type="nucleotide sequence ID" value="XM_018295084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VC60"/>
    <dbReference type="STRING" id="759273.H1VC60"/>
    <dbReference type="GeneID" id="28859191"/>
    <dbReference type="KEGG" id="chig:CH63R_00109"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00109"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
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        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
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    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="678"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="819"/>
            <end position="945"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="518"/>
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            <dbReference type="ARBA" id="ARBA00004255"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
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            <dbReference type="ARBA" id="ARBA00022927"/>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF37813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="956" mass="106513" checksum="1D4C7AF71431F8D1" modified="2012-03-21" version="1">MASFLENAYSLVHQDNAADIPSLSDLRTQLEKGTDESKVETMKRILTIMLNGDPMPNLLMHIIRFVMPSKHKALKKLLYFYYEICPKLDSNGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREPELIEPLLSSARQCLEHRHAYVRKNAVFAVSSIYTHSASLIPDASDLIATFLEAENDATCKRNAFAALASIDHEKALLYLSTVFEGIPNAEELLQLVELEFIRKDAVQNSQNKARYLRLIFDLLEANASTVVYEAASSLTALTNNPVAVKAAAAKFIELSIKEADNNVKLIVLDRVDQLRKKNEGILDDLVMEILRVLSSPDIDVRRKALDIALEMVSSKNVEEVVLLLKKELSKTVDQEYEKNTEYRQLLIHTIHQCAIKFSEVAASVVDLLMDFIADFNNTSAVDVINFVKEVVEKFPNLRKPIVQRLVATLSEVRAGKVYRGIMWIIGEYSLEERDIRDAWRSIRASLGEIPILASEQRLLDGDGDEENKEQVNGHSKPAAPTGSRKVLADGTYATETALTSQSAVAAKLEAVKAAQKPPLRQLILDGDYYLATVLSATLVKLVMRHAEISAESARTNALRGEAMLIMISIIRVGQSQFVKAPIDEDSVDRIMSCVRSLSEFTQNKELETVYLDDTRKAFRAMVQAEEKKKAAKEAVEKAKTAIQVDDVVQIRQLSKKNANDGLDEIEVDLERATGGEATAEDLSSKLSRVVQLTGFSDPVYAEAYVKVHQFDIVLDVLLVNQTMETLQNLSVEFATLGDLKVVERPTTQNLGPHDFHNVQCTIKVSSTDTGVIFGNVVYDGAHSTDTNVVILNDLHVDIMDYIQPATCTETQFRTMWTEFEWENKVNINSKAKSLRDFLEQLMAATNMNCLTPEASMKGDCQFLSANLYARSVFGEDALANLSIEKEGEDGPITGFVRIRSRSQGLALSLGSLKGLNKIGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VE95</accession>
    <name>H1VE95_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09608</name>
        <name evidence="4" type="ORF">CH63R_01369</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003031">
        <property type="protein sequence ID" value="CCF38548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164706.1">
        <property type="nucleotide sequence ID" value="XM_018296344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VE95"/>
    <dbReference type="STRING" id="759273.H1VE95"/>
    <dbReference type="GeneID" id="28860451"/>
    <dbReference type="KEGG" id="chig:CH63R_01369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01369"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046465_0_0_1"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="252"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF38548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="494" mass="53183" checksum="A9C4D57163E7AF41" modified="2012-03-21" version="1">MRFPSFEDTFVTREDSATMPQSPNSQSLMTGLQLCLAHYCDQHGPTPLMVTEGLPVPCTTCYDDGAAGYADQDQLRPQASAPATTGSLNQTMAMSDALRNMHLNAHRSSSLPASENEAQVQRAAMLRASAANSPASPLSPSAIETPPDSPRRISEQQPQPRRDSSFRRTYDEYVTKRAGPCDNCALTLPQRQGGKDKTDMKAERGPTLRTRAPYARVYGQASPPASQTSSASDTDGESQPERMHRRATGSSTTRSSMSSGRHTSHTHYLDYTSTHEPLIATSFSIVRSSCLRTLSLETLPRAPANLTPSASPQSNNMPAFVTTHSAGAAASGGPIFFGDPVNGYTTAYIFRIPDMHARGHKRVYAFLALSTHKERLAMKTFGFMATAFRDLASWIQQLAEAEAEKAAEASPVGGPQHHSSYHTINRPDREGPDRGGSSFLTGGGGFSRRMGGGPGGVSLKARGLAELVGMPDFFIDLHAKFVKLMLELGVVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEJ3</accession>
    <name>H1VEJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylethanolamine-binding protein pebp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_01951</name>
        <name evidence="5" type="ORF">CH63R_04207</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003079">
        <property type="protein sequence ID" value="CCF38646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160428.1">
        <property type="nucleotide sequence ID" value="XM_018299182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEJ3"/>
    <dbReference type="STRING" id="759273.H1VEJ3"/>
    <dbReference type="GeneID" id="28863289"/>
    <dbReference type="KEGG" id="chig:CH63R_04207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04207"/>
    <dbReference type="eggNOG" id="ENOG502QPQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_4_3_1"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497660" evidence="3">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="309" mass="31214" checksum="64AE2C1728584EEE" modified="2012-03-21" version="1">MLSKAIAVLAAATLTSAATPMGFMPASNTPLIVSYGGISALDGVNLPKDSSQVMPTIATEQQLKGQYAVIMVDIDVPTNQPPKTGTLLHWLQTGLMSADTPVTLNTTAGPKRVFIMQNRMNAAALAPYLGPNPPAREPLSHRYTFVAVDHTTITQQGLMALSGAAQNRRDFNVMNGLMAAGLQDKVVAGNFFRVTNAGPVGAGQGLPGGGSRGNSTGGAPMQPMPTMPSGTPTTPGTGGGMPNMPGMTTAPGMTMPMPSAPAQTPGASAPPPGGAQPSAPARASAFGLSPSIGVVSIGLCLAGSLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEL8</accession>
    <name>H1VEL8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">CH063_09703</name>
        <name evidence="8" type="ORF">CH63R_11767</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003094">
        <property type="protein sequence ID" value="CCF38671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153582.1">
        <property type="nucleotide sequence ID" value="XM_018306741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEL8"/>
    <dbReference type="STRING" id="759273.H1VEL8"/>
    <dbReference type="GeneID" id="28870848"/>
    <dbReference type="KEGG" id="chig:CH63R_11767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11767"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087988_0_0_1"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF38671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="273" mass="30172" checksum="A0E064E0F1464CC8" modified="2012-03-21" version="1">MPPKKWDDEESGEESSGPASPVGGAIPIRRKFEDEEDEDDVLDSWDAAEDSEVEREKAKKAEEAKAKALEEAKKNKKSKAQRIAELKEERARLEAEDSGEEETEAEKRERLRRTEKESDLKHAEDLFGDIGVPAGRKANLAGSAVQIDPNDPTKTANIADMPLFNPITKTQFEHLRTTLTPILANNARKAHYGIFLQEFTKTLAKDLPSDQIKKIASTLTALGNEKMKEEKAAQGGNKKSKAAKTKVSAVVSRAPVADTETYEDDGFGDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VF29</accession>
    <name>H1VF29_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_01995</name>
        <name evidence="10" type="ORF">CH63R_08064</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02003179">
        <property type="protein sequence ID" value="CCF38832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157816.1">
        <property type="nucleotide sequence ID" value="XM_018303038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VF29"/>
    <dbReference type="STRING" id="759273.H1VF29"/>
    <dbReference type="GeneID" id="28867145"/>
    <dbReference type="KEGG" id="chig:CH63R_08064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08064"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_1_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
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    </evidence>
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    <sequence length="533" mass="57658" checksum="B98B146210992428" modified="2012-03-21" version="1">MTTFPKSFLAAVVKQLLRGKSLIQALIAFCITPQSVSGTRPTVECSKTATATTSTRNVDEFLKGAEDLLIGPLLGDGLLELSNALKAQFRDKLQTSMACMLPSYNHQLPGGHEVGQYLAVDVGGSTLRVALVELRGRDSKGSESEIVRMSSFKIDNDIRNLEGMAFFDWMAQRIWDMVSQDGQDTSRPTPVALAWSFPIEQTSLKGGRIHGMGKGFLAAEGLMGQDLGEVIESACAARGMNVQLRVILNDGGATLLSQAYIHPATRFGLILGTGVNIAAYLPVSLIGKPKFGDRPREWWDEARDVIVNTELGMFGQDVLSVTRWDALLKQGHPRPDFQPLEQMVSGYYLGEVVRIALVEAIRTTGLFGGVVPKSLDEPYSLASETISAIEGDATPLFTSSIDLFVARHPSSHTPTSSDISALRSLASFVSRRSAAIIAACLHAIWSLRLEALGREEPEDEFPDRLGQESGLVRTMVAYNGSVIEYYPGYLAMCQGYVDALVNRKDRSISLVPAKESSLLGAGVALARTCNAPA</sequence>
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    <accession>H1VFQ8</accession>
    <name>H1VFQ8_COLHI</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003290">
        <property type="protein sequence ID" value="CCF39061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554951" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="74" mass="7587" checksum="A9F475933E922EA3" modified="2012-03-21" version="1">MNFKVALALLFASVAMAVPGQVQHDSNVLARDPQRGPVRPSGPSCCSYIPGDCNCGCCSGGPCATFNNPDATCP</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Wortman J."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
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                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
        </source>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07295"/>
    <dbReference type="eggNOG" id="ENOG502SY26">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_083658_0_0_1"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
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    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
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            <begin position="78"/>
            <end position="98"/>
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            <end position="54"/>
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            <begin position="102"/>
            <end position="136"/>
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            <end position="51"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF41419.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR08530.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="32453" checksum="F20A76736F419062" modified="2012-03-21" version="1">MTHPRLSKWFSGSAYIPVSNHDRDERDAGVTYKDEEGATTEQAHLGSSSKPASREITAPSGVFASFKNATPSLKVNGLMLLGILCLLGFIIALAVPSAHHSHASLRRPPKQHPHGMQHHEAQDRPKQVPHVPQCGSTPVEAKTRSCMFEQQLGAWVPQACAWKEIVDEFLDVVGDIYAEWSWYWDADLKREVNATSIPELQNGNFSVIYTTYPRAHDLHCLYCWRKVEYALEHGVEWMDARCHQFWHTKHCVSLIAETLTDQAEEHRGLTYPLLYHDCVPLTSTKES</sequence>
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    <name>H1VUF0_COLHI</name>
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        <name evidence="3" type="ORF">CH63R_02458</name>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006431">
        <property type="protein sequence ID" value="CCF43859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018297433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUF0"/>
    <dbReference type="STRING" id="759273.H1VUF0"/>
    <dbReference type="GeneID" id="28861540"/>
    <dbReference type="KEGG" id="chig:CH63R_02458"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02458"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET_dom"/>
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        <property type="entry name" value="SET_dom_sf"/>
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    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
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    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="145"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="463" mass="52281" checksum="944E48B961E560D1" modified="2012-03-21" version="1">MKPSLVLLGACSSALAFRDSKIISSSSGEMCISSQLLAASSSNPICRNKDGADLLSGSGRGRGGDQFSLAGSIPPSPTTPHSNWTHTSPCFRNGTDSPEFCIYHAAHYGGKGMSIITDAERAAHITRNWGFTRPQELEGVNRPLPKFEVAKVPGKDYGLVATIPIRRGEVILRETASLLIDYAAFTHVPLDEMKKLQVHAIDYLPFNHRSQWLNMSSHGFQGDHTAMVDKILLTNSFDVEMDDVKRDDDFYAVFVNTSRMNHDCRPNVDYWFDPRTLTQRTVAIRDIIPGEELTLSYIDPMQSRAARRERLHTTWGFHCSCNHCMQHRLKTDESDRRIEQIASLREEFNDYTPASRATPQMAELLISLYEQENNWSLLSEAYTLAAIEYNGVGEPWLATKYARLAVEAGLMTLWEGHGDVVEMTKLAEDPWSHWSWMLRTRKRYSWGPGSRPNQSEDEDEDDE</sequence>
</entry>
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    <accession>H1VUF6</accession>
    <name>H1VUF6_COLHI</name>
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        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">CH063_03177</name>
        <name evidence="3" type="ORF">CH63R_12516</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006434">
        <property type="protein sequence ID" value="CCF43865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151907.1">
        <property type="nucleotide sequence ID" value="XM_018307490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUF6"/>
    <dbReference type="GeneID" id="28871597"/>
    <dbReference type="KEGG" id="chig:CH63R_12516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12516"/>
    <dbReference type="eggNOG" id="ENOG502SHCH">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_063723_0_0_1"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF4">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="32168" checksum="4758C08FCD9059BA" modified="2012-03-21" version="1">MILPHAAVRSLQALSLNAARQPLQSSSIQCPIVLDGRIPQNFTLQVFDTNESPFNPGFTKGPAPWSEILLFPAGVTPSRFDVVSEPTATSFKPLEVTIDDKSIFDPSGNNPQLGFRRAGLLLGNGSDASNQGVMTFHWSSRQDPARKLNLTHEYLTSFHETNDSGGAQFSLQVGTPLGQDGAAGKPAASDWKMLNRNNTVVFSTPLKFDAWQNFAVTLDVPKNTMQVYFSEGNDPLKPVTEILPNDNSGGGALQIGLLKKPTETKTVVFDGFQESNIDEGQILGSIFVEDSANGCVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWW2</accession>
    <name>H1VWW2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_00525</name>
        <name evidence="18" type="ORF">CH63R_02306</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CACQ02007124">
        <property type="protein sequence ID" value="CCF44724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018162097.1">
        <property type="nucleotide sequence ID" value="XM_018297281.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VWW2"/>
    <dbReference type="STRING" id="759273.H1VWW2"/>
    <dbReference type="GeneID" id="28861388"/>
    <dbReference type="KEGG" id="chig:CH63R_02306"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02306"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_003051_2_1_1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="65"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="16">
        <location>
            <begin position="249"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="625"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="131"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF44724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="899" mass="98778" checksum="7549276FDD539251" modified="2012-03-21" version="1">MAMLAPKTAFAPPLGSGNPMMPNLSAGSVPPSRRAPSVPNQTTAYASPTESEFSESDGPDAVKNWDEDKVCEYLRSAKCGEYEKLFRKNHINGENLLELDKDVLKEMGIDKVGDRVRLFLGIKKLRTKAYANQKKRNRDSFGGLDQFTPSSGGSPRPSASATRPAPAPSMNKRYSRQYDTIPLESTSSRPNSPLPGSDAIRPLRTRYGQSPGYVSTAGQSVPQPGRLVTSHTRNNSSMDGSLMAGLPQNQDVIRVISTGGVTKVVKIADCNTCEEVMRVTLRKFALREDHERNYCFWVLAGIEPDPNQCRRLGDTELWRIIKDQKRPERNRLILRRVPAGEPGMPELERAAGIAIEEAQQNHSRALETVDKRSQMKVQKLLGERWNDELQHPLSPVSFHDRERNVYNTAKELERPASNDGPRSSGGPRRNKGLLRSFGGLRPPSELIASDLTSYFPDHPREEIDRTARLSMRRSTRLSKVNSRLSVASNLSFASSIQDAPPIPTIADSWLHAGSAPKARSGLRVAHFRDSVASSVLGTLQEESPVEPNRKSYVSFADSSDGASAAALSVTDPEGNITRRSYFDADGSTGSGSLKDLTQALNEDGEDADEELESFLAGESWSDDKWMKGAMIGQGSFGCVYLALHAVTGELLAVKQVEAPAPGANSQNDARKKSMIEALKREISLLRDLRHPNIVQYLGCSSSSEYLNIFLEYVPGGSVQTMLNSYGALPEPLVRSFVRQILTGLSYLHDREIIHRDIKGANILVDNKGTIKISDFGISKKLEATNILSGANNNKHRPSLQGSVFWMAPEVVKQTSYTRKADIWSLGCLVVEMMTGTHPYPDCSQLQAIFKIGGGKAAPTIPDHASDEAKTFLAQTFEMDHNLRPSADELMLSPFLTSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1W374</accession>
    <name>H1W374_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03998</name>
        <name evidence="3" type="ORF">CH63R_09862</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009201">
        <property type="protein sequence ID" value="CCF46937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154260.1">
        <property type="nucleotide sequence ID" value="XM_018304836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W374"/>
    <dbReference type="GeneID" id="28868943"/>
    <dbReference type="KEGG" id="chig:CH63R_09862"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09862"/>
    <dbReference type="eggNOG" id="ENOG502T46Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525800_0_0_1"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF46937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="518" mass="58661" checksum="1B97D0A0D56477B4" modified="2012-03-21" version="1">MSDPQNGGGPVTFVRRDVSVNSVKLSELLEQEAHQRYLEQELRRYEPGEKLTLYPRDPGAPHGLPDYEKPPEHDLPDGWIPYFDPTTEVSVQEEAQIEVLEVIAGGTKRGAQLLLCKVLKAPAPPPPDLPCYHMSFDVGMKLVLKVFDSIFFPEVWDWHWTQLAVPKDVRVDGRLSRQANVYQHLFSKGITGHPHIVPQYHGSWAMKFAVGDSSETQWRCAGAVLIEYIEGTSMEALCDRDEYERMVPETGFLSLPSSADGSLGVPFNDLTNRLRVFKAFLDGLVSFLHTGSHLQTYNPPDVFLTLGNNGVDLNEPRVVILDYSHCVVWSQTIQSKIGRADEVDTKFPAVPSRLLLDKHPNERLPNPPHPAWMFNHMTFSDFAGWFPSEWMKDEAGFEQWVEAEFGEPVERKYSTLETLNNAMDLAIADAVRLYASERGIHPDDAYTIRDSFDDHQLGACFGEPDPMLLRDPDALRIHVEHLQELQETTLTQMRREKSVLEKLAREEAPQDAKPVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1W451</accession>
    <name>H1W451_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-rRNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_04102</name>
        <name evidence="7" type="ORF">CH63R_10107</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009534">
        <property type="protein sequence ID" value="CCF47264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154505.1">
        <property type="nucleotide sequence ID" value="XM_018305081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W451"/>
    <dbReference type="STRING" id="759273.H1W451"/>
    <dbReference type="GeneID" id="28869188"/>
    <dbReference type="KEGG" id="chig:CH63R_10107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10107"/>
    <dbReference type="eggNOG" id="ENOG502QZVV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006918_0_0_1"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="460"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="585"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="723"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF47264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="846" mass="91185" checksum="D1092E705B32B50F" modified="2012-03-21" version="1">MAEDEERSPLLAPKGKGRAGDDSSLSESAPLLSSSSATPRYDGEQDDPETSRAPSLASNPPKAKGSSIRWASLISISVLILLVIGIMAGCFFVPSAVQEYAKQAAVVEPTNLALESITTDGVRARVQANFRLDGSRVQDTTSRRIGKITTWIVRQLGTEKTKVGVYLPEFDGALLGTAVVPPLTVSIVDGQTTAIDFIAELSPGDAEAYRKIANEWLDGKLDQLKVLGKAEIPLRSGIFPLGTHPVSEVLVFEANQIPTLPQYNISRLNFRDVPDREGQRTAVGADVTITAYNEFPVSLDVPELGFEVLVPNCNSFDPYILLADATTKPLAIKPRSDVTVNVSGIIRELPKSLTRICPNSKSSPLDKFLEQYMHGEAATVYVRGRKMPDSDTPDWVGDILSEITVPVPFPGQGFDNLIKSFSLTDVNFQLPDPMADPDDPDGAPKVSGTVEVLASLPKEMNFDINVTDLRATADVMYQHKKLGELNLDKWQPANSTKVDGTEKHDPLLKIMSRVVDAPLNITDGDVLTDVMQKLIFGGKEVLLDVKASVDIRVNTALGNLVLKDVPAEGKIPVKPLPGETMGNIHPQVGDVKIISTSSSSMTIEASVNITNPTPYTAVVPYVNIHIVRDGFVLGSATAENMKVVKGENTNLIVKATWDPAVEGEASRKAASDMISEYLSGRNITIDVKTHRGTIPAAPLIGEGLSKLNISIAAPKLELPGEGEKKGHFIRDATFHLLSSTATFTLVSPLRYNTIYVDWINATALYNHTESVGRIVYGLPFAAPPGTSTTPKLPVDWSMGSVGYDAVKRALGGALKLDAIANVTVRIGNWKETVWYEGQGIGASIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQC5</accession>
    <name>A0A1B7XQC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150483.1">
        <property type="nucleotide sequence ID" value="XM_018309511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQC5"/>
    <dbReference type="GeneID" id="28873618"/>
    <dbReference type="KEGG" id="chig:CH63R_14537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14537"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR01965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="112" mass="11893" checksum="2AF8B6DEED0CFE9D" modified="2016-11-02" version="1">MPDEKYRSGLPVPISSHTADYNCHRDLAPHVNLHAASHTQSGHGGPDNGDEALAALTSRAAPAPVLLPCWLCRAPAPGGERRGSEKNMNACVRRAGANSRRHPVRGLSDADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQR8</accession>
    <name>A0A1B7XQR8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150628.1">
        <property type="nucleotide sequence ID" value="XM_018309385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQR8"/>
    <dbReference type="GeneID" id="28873492"/>
    <dbReference type="KEGG" id="chig:CH63R_14411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14411"/>
    <dbReference type="OrthoDB" id="4840098at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="464" mass="52603" checksum="E2ACAD4C10BA5B47" modified="2016-11-02" version="1">MAQPTLLTLPVELITTISHNLTAVDLQSLRQSCKAAAEKTSVCFQERFFRTRYVMLEQQSLQNLIDISEHSTLREAVRSVALCIDHLIDPRDYRGRAQLRARGVNDEDDRVRLDDGETVSLGDDTPGSINMGCYQEAWAEYMAFMTKKLHFKHLAQAVYNLPHCRKVSLEDAIRPWGAFRLGRRIGTLPSRFVTDALPNSVLHAMVCIRTLFVAVVKSRLPIEELHIDFGTGMAGCTAVFPRILSLPRELAQAARTQLRTVTTLHIAINPYPRDNKFNPMYYNGLPVTDPLRNETADWTEDFLRFIGLFPALSTLSLYFFRRDEGYQFPRLSRELFVPHLQSISLELVDCTRSDLMALMERHKETLRTVRLESVSLLGGSADRWSSVVQSFRHDFSVRKLILGSCFVDRPWPTTDLPEKMYARTPQELDMLVAELLELEKSDGSTEQSSQGGDSTETSPAGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRW5</accession>
    <name>A0A1B7XRW5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_13754</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151046.1">
        <property type="nucleotide sequence ID" value="XM_018308728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRW5"/>
    <dbReference type="GeneID" id="28872835"/>
    <dbReference type="KEGG" id="chig:CH63R_13754"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13754"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="269"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="583"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="764"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR02528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138542" checksum="E75773FE19608BB3" modified="2016-11-02" version="1">MSSCRRTACGDLELFEASATIAIRGPESRPGHLTVPTTMDDLLNLELLSLVSKVTSELQNHLGVSDKTLAEFIIAQRVDAEDYDAFKKKLAAMGADFPPSLVESVDRLVLTMHPKMKGKAQKNGAGAGGSSEDQHHRSTAEKEQIFRGLSVPDKPVAYDNIGDGVDAIDDTLALLEGLEGKARKEKPDSRKRSRSPDDGREARRKHRGRSRSRERRKRDKYRSRSRSFDDYENGPSLKQRSKRRNYDNEDDDRFRRAPEPEVDDAPQLHKVYSGHVTGIKDFGAFVNLHGVRGKVDGLVHISRLVEGQRVNHPSDLLTKGQEVKVKVVNIEGNRVGLSMKEVDQETGLDLHPEVRISSGANLEALGGGGSRNNNMFDDTPMPPPQHQPRRQKKRMTSPERWEIRQLIASGVAKASDYPDLEEDYNATLRGDGELELEQEVDIEVREEEPPFLAGQTKQSLELSPIRVVKAPDGSMNRAAMSGTALAKERKELKQQEAEAAAAEDSKVDLSAQWNDPMADPDKRKFASDLRNAKSQMGQNKPDAVPEWKRAVAPKDQAFGKRTNMSIKDQRESLPVYAFRRKFLDAVREHQVMVVIGETGSGKTTQLTQYLAEDGFANHGVIGCTQPRRVAAMSVAKRVAEEVGTPLGEAVGYTIRFEDKTSPATKIKYMTDGMLQREILVDPDLRRYSVIMLDEAHERTISTDVLFALLKKTMKRRKDLKVIATSATLDADKFSSYFDGCPIFTIPGRTFPVEILYSREPESDYLDAALVTVMQIHLTEPPGDILLFLTGQEEIDTSCEILYERMKALGPNVPELIILPVYSALPNEMQSRIFDPAPPGCRKVVIATNIAETSITIDNIYFVVDPGFVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTTIPEIQRQNLSHVILMLKAMGINDLLHFDFMDPPPINTMLTALEELYALSALDDEGLLTRLGRKMADFPMEPSLAKVLIISVDMKCSAEMLIIVAMLNLPNVFYRPKEKQSQADQKKAKFHDPHGDHLTLLNVYNSWKQSSYSSPWCFENFIQARSMKRAKDVHDQLVKIMERYRHPILSCGRNTQIVRQALCSGFFRNAARKDPQEGYKTLIEGTPVYLHPSSALFGKQAEWVIYHTLVLTTKEYMHCTTSIEPKWLVDAAPTFFKVAPTDRLSKRKKAERIQPLHNKYAGEDDWRLSAQRKGGRGGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRY2</accession>
    <name>A0A1B7XRY2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn 2cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151018.1">
        <property type="nucleotide sequence ID" value="XM_018308700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRY2"/>
    <dbReference type="GeneID" id="28872807"/>
    <dbReference type="KEGG" id="chig:CH63R_13726"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13726"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="39"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="308" mass="32931" checksum="17C4289F6CE58921" modified="2016-11-02" version="1">MSAVRNLTSRRISQLSHHLATSSPRAMSSAQGSASPGPAPWRAAFLENVTAMASPEFSLATLHSAPSTAAAAAGAGAGAVPRLRTVIFRGLWASLPVNPKNTADLNPPAYESDLLTLTTDARMAKVPDLFGGSSASSSGGGGPVEACFWTDAKVQWRVRGEAYILGPDVEREASTAVRDTLLARMRRVSDKTADDGWSFAREVTAHFGNLSPMMRGTFRNPEPGTPRGANPPGDQLKLGQKVEDLHDEVARANFRVVVIVPTEVDQTDLSNAEDPRRWLYRFVGAAADGEPADGAERSNGWEKVELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTG8</accession>
    <name>A0A1B7XTG8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151566.1">
        <property type="nucleotide sequence ID" value="XM_018309248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTG8"/>
    <dbReference type="GeneID" id="28873355"/>
    <dbReference type="KEGG" id="chig:CH63R_14274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14274"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38390" checksum="E5EC500F5C5C0F3E" modified="2016-11-02" version="1">MSTETKPPANPRHWAGGIDQYLADNNITCTSATPIEAGTSCYIWRLDGFSHPDHPPGEPAVLKCADSTPKFSDDAVSPARLSTEVRALTCRAVAEASRAEPSVRVPSVLRTTENGFVMSWAGDVNLLDAFRSNPALDMADIGARIGAWLGRLQTAGAAEGPSGFELVNPELGRFYNPGGFMDKLVQSVVTDGDESDRILAALRGTESARTLTAWDFRPMNALLRFSGGPDRGGTAPDIYIVDWELAQFGEAAGDVGMWCVEAMVLEGKHGDRGLLRSFLTAYRQHAAAGIVDEAFVRKLAMVVGVMLVYFMRIAPRLWGSTEEEVAGWKGAAVEFLRAGAEGDLGWLRGSLIGVVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTK5</accession>
    <name>A0A1B7XTK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151627.1">
        <property type="nucleotide sequence ID" value="XM_018309309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTK5"/>
    <dbReference type="GeneID" id="28873416"/>
    <dbReference type="KEGG" id="chig:CH63R_14335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14335"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="444" mass="49762" checksum="3994A29273EDDDF3" modified="2016-11-02" version="1">MPISRNSNESSTCSMEIHRNPEGSGSRVSLRSSRDWNHEIRNEFADAAETCFVRLATQHAAGYLPLSDYLDGVLSHLRKGATTHKWDVPPEDFSDLLELDLFAGAVKARHLDPAFVPLEEHDYFKAKRLASRSWTTSDPDEFDRLGREDQTDPSALLPEIADLLLVICYARRHTLLFRHLIRLLPGPPDRSTFDLLDEMLLQPRTAYWTVIHQHSPKQQSNSADEITMWTDILNFGWVHDPVSSETQRFLHHGIRSQDPSIERDDSVAFGSQKLRDFHLALASRGLYCDVASLGDHLARCKSLDQALDFLTVFPGNKVRPSGRDLYEWESGGLVGSIADSSTLDGKLRTDIMRLALECIEGVDVNAPFNSNAWEDDLPGRKRTPRMTGLQVAASKGDRELSEVLLQHGARTDVVEYITGLNAAGFARNNGHVDLAEWLDGLSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXL4</accession>
    <name>A0A1B7XXL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152998.1">
        <property type="nucleotide sequence ID" value="XM_018306157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXL4"/>
    <dbReference type="GeneID" id="28870264"/>
    <dbReference type="KEGG" id="chig:CH63R_11183"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11183"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="281" mass="30642" checksum="B4C4B8D8F49E5F6D" modified="2016-11-02" version="1">MEGLLQSHIIRGCTTSLIWKCMAPPHPPRTPADIQLWVERQSAWAAFQSPFPAPTQATLDRQLNKCFWKLRRERAGFRGEVLDELSSDGESRSDGKEAMSPSFELHSHIPVAMLQVHIQAREANLCHTPWCGGQLTVIDDALVRWSSAIQQRIVEWTISALVGTQPESRLFLTPIIHGAVTDEDSAVSLTSLCKRVPVCGAGNLGTQPALSGHCRLQVLPPAAPKEVPVQSPLPSTIHYPLSGLGKPASNSKKASVVFKPFTFANTISYASRGVGQQLQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXY3</accession>
    <name>A0A1B7XXY3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153122.1">
        <property type="nucleotide sequence ID" value="XM_018306281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXY3"/>
    <dbReference type="GeneID" id="28870388"/>
    <dbReference type="KEGG" id="chig:CH63R_11307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11307"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003431">
        <property type="entry name" value="B-propeller_Phytase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02333">
        <property type="entry name" value="Phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51662">
        <property type="entry name" value="BP_PHYTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601177" evidence="4">
        <location>
            <begin position="26"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="54"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="BPP" evidence="6">
        <location>
            <begin position="438"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="794" mass="84407" checksum="B18DD1297001883B" modified="2016-11-02" version="1">MILNGLLLLPLLWRAFLLPVLPCRAAFFRLDTNAMGIKHLACAAAVAAFAAHPWLATTAAAAAVNLELNITALTGGEIESDWTNVFYSREKSPLLLGNDGGAATGGFRAWDLSSDSPLSEVKAVITGRTKLVTTVYNVTGKDLAVTIAMPDSVIRVYELPAFTEIEAARTTKLGDWSAICSWRSKSLNDYVFLFGKTLVVQYLVRQGKSSVELVEVQSIPTPTEFSGCAVVQSQAKMIATADDDKDLYIFDLKESTTAPDVTKLGEASEDVTGVAVYASNSTGLDYLFVAQESSVAVYEYPFDLLGTVKLTGLEDIEVQGLSLYQGSTAKYPSGALGFAVEADNDVAGFGLLSLDGALGELGVSVNTAYDPRSQTGCRARSNICDACSGNGYCQENALGCACFAGFTGDKCDAFRCTDDCSAHGECVGPDRCECASGWGGLHCSFLLVEPSFETEQNGGDGDDPAIWISPESADRSRIVTTTKSTVGAGLGVFDLAGKLLQTIPAAEPNNVDIIYNFQAGDRKVDLAFAACRGDDTLCLFEMTSNGTLKEIPGGVQPVVPDYTVYGSCVYKSPKTGKQYLFVNEKSARYLQYELTATPNGTLQTALVRDFTGGSGGQVEGCVTDEDNGWIFLGEEPSALWRYGAEPDSKEAGLRIAQVGDGRTYADVEGVTLVYGARPDQGYVIVSNQGVSAYNVYRRAEPHDYVTTFTITGSADGRVDAVSNTDGIAAVGTHLGRDFPHGLVVTHDDANQLPNGSTSAEASFKLVSLEKILGAGALKSLNLLDDVDAKWDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYC9</accession>
    <name>A0A1B7XYC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xurface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153284.1">
        <property type="nucleotide sequence ID" value="XM_018306443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28870550"/>
    <dbReference type="KEGG" id="chig:CH63R_11469"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11469"/>
    <dbReference type="OrthoDB" id="4849809at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1513"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1389"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1616"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="2017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2029" mass="216501" checksum="2683D6EFF780B46C" modified="2016-11-02" version="1">MQWTSSGSWQQKPFRFLLRISNTQTALKSAWVIRHKPIHLKLIHLKLIHLKLIHLKLIHLKLIHLKLIHLKLIHLKLIHLKLIHLKFIHFKLMTPFRKPPSPWPWRPRETTSHGKVHQENQKHQTLTSAMFRSGALSPAPPSHPPALGTSLAPQGDTNANRVHQPPPLGVKAGSAEHVFSLLRGGRGLACPHFPKYTTAGVSTARRKYPSRLGFFHASSPKGHISYLETAKFCAACLDQAVPSGYNYWSMVPDGNGSVKGGRWLDTAASSQTYPRLYQSGTERFDKTTVSPQSVPEHLLTSPKEVPIPKVPGALDAWRWLQAQQKPFYLDGLHLTNGSTPFAQLSVEEDSAIVKTSGEPYIAGRSTHAADSQVHQRHVEEGSVVRPKSLQAQRFFPDGFVPSGKPNESAAASTVSLTISKNPAFGTASTSSIKRKAVPARGNGPGTLPASATPPVQQRAVTSPPGLPQPPVSRPEAIHHDAVTGKTMSPQPKAHFLDGSRSISQPTSVFGVDAGQGPHVLVPRNTAALDPPDRTKLPQGDPRFLQDARSSSAISSPQSLSSPTVPMRGAKTPQEVAPSLDRGSSGGNQPISRTSVRSQTGEPTKPALPVLGPKPSDKSKDGRKEQPTSDATAGQVPQDKPTARSSQPRKAESSSQVGRDTLPNSDRTRFARNWYRHDPIDFDELDGPSSPPAEQTPDTRSEETPGTPLPLPRILPQPRSSKTDATDYKLAATAVAELFRLLQSPPEGKSRAKRTLSLPEASNRGSLERSSGVGEPAIHQERQVTKPSKKSKMPQMMSGIPETMSSVAYDTSSMPQKVPYAIQTRSRPPKISNAPQTVSGVPPVVSNVPQTASDAMQKAPSRPPKITNAPRVVSGVSQTMSSAPQKIKMPSVPRKISGQAGSQAMPSIPPQKRRTHEVVEEMPPSPANQLTVTDRSIAKKPSPARPLRSAPTSSQYPVVPSHQPQDTRSLGAAGSKTKSAGPAPKHATGAEKKDAVRSVVDTWRQKTASGSKANPDRGSKAPKPSTVKVADGKVKTKRTAPRAEPRKRRVGDTKKIPGAEKKRKSHPKDPGSLRVPGKEKRGGRSSLGHGKPGAHDTHTTTKISSMSNSTTNCPIYLLGGGSRDSDSDSDVENDDDMSDSDYASNPFQTSDLDDDEPAQEGGPNQSDTEDAANASQDGGPGQDSAQDSRPSSPEFPPGEHVPNPPGQSALTQAEAGRPDSRISLVSQPSIPDVSVPNPSLGGTQQPGTAHDSPRQSWSADQDASDPFGNQQTSVSSGPYMEPPFDTGASSSYCSSPPWLGQTLAADTPQQHSPLEPIGFENSRGLPEQGQTNSTLPNNSQQVDSVSSWPSGTIETAPLSSTDQHGYTAMPSAPSSGNPRVFDGSYYPPVNSASASNDPFQGQAESSQPSFVGDQSQASFLTRQQASVLPSGTSRGLSRNQAQAGADSSGQRNFEMGQSGQMPTSVPEPAPTTGQPAPLGQPGSPWPTATGQGLNASYFSEAPYTSAEAAYDPYSTSLLAPEKHADPQPDPWTASRTGNTAEQTSPWAPKQYEPFSPSSPTVPVPSFSSNQAWDQQAGPPATFGRQQERQPFPGDQSLGTDPSEWNSRDKSVAPTDSWDPNATRQSSPAPYAAQGSQRAPYGSYQSPPRNRLYALGDPSPQRTGGSNKGKILLAAAAGAAVGIGAAALLSRSSSASSKSSHIQSPPPGTDVKNYAAWGNVPASNDGFPYDGAYSGSEKAGGASSSSSSSPSSSSSSGHGNRDDPAQREAASHDWNDVDSDDNQSGASNDEGFGMRDDGDESDNHSVASDQLTSLSYDNENAPQAPSVSGASDSDQAGWYDGDGYGSAWNDEENHDQGSQGSDRSQAGEHDMYGSDQELAYNSEPQGQFTSGSDQGSESEQEYMVDDEAVHEESPSSVAGSDHYLEQSGTEQDESGLDEEGEDCIGHEIVDESDEAEGYGEEEQDGSQEDEYEIENDGEEEEEEEESEEEEEEEEEESEEDESEEEEEEESEDYAEEYDEGGGGSDSDAYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ75</accession>
    <name>A0A1B7XZ75_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153568.1">
        <property type="nucleotide sequence ID" value="XM_018306727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ75"/>
    <dbReference type="GeneID" id="28870834"/>
    <dbReference type="KEGG" id="chig:CH63R_11753"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11753"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="50737" checksum="C7BC37861E0FBCC4" modified="2016-11-02" version="1">MSAPSNSSSPLISTRRRACTACQQAKRRCDQRLPRCGRCTQKGLEDCNYPSLEAAVAAADFNFFTDVLSGSAGTPTGSLHNIMPVPVVPETETPWSLFYGNAAAPTPSPSVMSPPASDCISRDAVFYCNEQFRCFPRRWVGQNGVAPFIHPALYLPTTNGADGLPPVLQDCFCACAAYAAKNDENSALVLGVVEAKATALLYVPEQATWTLPQQVAALQALVMYQIMRWFDGDIRQRVLADSVEPVLAAWTSALQSRVGAAVFAEEAVPPSVIPEVIAHVPPPQQSSSATSSYPQHQQQQQQHDLSPDNSRSNTPGGGGGGGGGSRLAKEELKAAWRRWLMAESIRRVLIMAHLVRAVYATAKQGGAYGKLGGSGSGGGSGGHPHPHLHHHIMGLSDMGFTAQARLWAATTAERWSRSREGDTAWWVSRMDFSGLLALADPREVDEFTIMLGVVFRGKDVVEDWITHGPGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0A8</accession>
    <name>A0A1B7Y0A8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_12146</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153961.1">
        <property type="nucleotide sequence ID" value="XM_018307120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0A8"/>
    <dbReference type="GeneID" id="28871227"/>
    <dbReference type="KEGG" id="chig:CH63R_12146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12146"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="530" mass="58650" checksum="CC558BA6424E3102" modified="2016-11-02" version="1">MTASNTASILFPGGEDNMSHHQSPRISEKQTIESHIPSITSDAPNTSHTRWWKDRGLRSLNLRLLAVFISPLMIGYDGTLIGSLLTMPHYLGLNPESSSLIGLMSAGYSFGAMIAFPALSWALDTFGRRIVIMAGDLVIIGAVLGQIFCYDARLYVLTRTALTYLLINEQLGMGSMLVTASCPVLLTELAHPRQRSFLVSGYGSLFFVGSLVVAWVSFGTLHIPTQWSWRIPTLLQLLPPAAQLPLIFLLPESPRWLVSHQRHSEARDILVRFHADGKPYDEVVLTQYTKICQAIELDVQGQVTRWVTWFHGSGNRRRLLLVVFCTVFGSWSGGGIITVYVSVALRQVGITAPAQQAGINGGLQVFNLCAALLGASLVDKIGRRVLFVSSSVIMLFAMVGFTVATEQFTQSPQLASSRALVAMIFLFQFGYDIGYAPLTPMYIAEICPYHLRAKAMALHYLLMYAFSAASHYANPVALHSMGWRYYIVYVGILAFEVLFTYFLFPETKGYTIEEISSIFDKPEPTSSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y147</accession>
    <name>A0A1B7Y147_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154251.1">
        <property type="nucleotide sequence ID" value="XM_018304827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y147"/>
    <dbReference type="GeneID" id="28868934"/>
    <dbReference type="KEGG" id="chig:CH63R_09853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09853"/>
    <dbReference type="OrthoDB" id="10507029at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="234" mass="24972" checksum="EA5D05F5F1F5140C" modified="2016-11-02" version="1">MPFRVAIMTRPTADGIHELYCELYTSDLKNDPGFIEAVTPEEAKAEYNLDASHLLEAQRHSNNNNTNTNTNNVNVHVHNQPGPRRRSPSARRVNNHPASSSTRNVAPVGATNTYVHSMSGGTMVIAPCNRVGIARNAASAAAAAAAPTAVRRVHNGARRHRDDDYNDYDYDDEAIGGGPARGWLAAPRGGVAGDPLGAEDPGREAVERGLRLRFAMEMGFGSLAGRGFGANGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1H7</accession>
    <name>A0A1B7Y1H7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_09972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154370.1">
        <property type="nucleotide sequence ID" value="XM_018304946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1H7"/>
    <dbReference type="GeneID" id="28869053"/>
    <dbReference type="KEGG" id="chig:CH63R_09972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09972"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR05852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="127" mass="14651" checksum="62D45DF5A23BA5AB" modified="2016-11-02" version="1">MQRQLLAAAARAARAPATRSTVQRRFASTTDNAFIREREAAKHHAAGTTALWRKISIYACIPALGLAAANAYVLWNEHWEHWSHLPPLEERVEYSYQNIRTKNYQWGNGDKTIFWNDNVNYHNKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2N0</accession>
    <name>A0A1B7Y2N0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoribonuclease YSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_10390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154788.1">
        <property type="nucleotide sequence ID" value="XM_018305364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2N0"/>
    <dbReference type="GeneID" id="28869471"/>
    <dbReference type="KEGG" id="chig:CH63R_10390"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10390"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="9">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="10">
        <location>
            <begin position="425"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="754" mass="83038" checksum="E552AE4FC93E5402" modified="2016-11-02" version="1">MTHPTKAIYKWLIQDSVRVGNTSSNPTSQPVYTEADHLNTFPQIEAIDYHTTHTISSIRITPYPAGHVLGAAMFLIEIAGLKIFFTGDYSREQDRHLVSAEVPKGVKIDVLITESTYGIASHVPRLEREQALMKSITSILNRGGRVLMPVFALGRAQELLLILDEYWGKHSEFQKFPIYYASNLARKCMVVYQTYVGAMNDNIKRLFRERMAEAEASGDGSGKGGPWDFKYIRSLKNLDRFDDVGGCVMLASPGMLQNGVSRELLERWAPNDKNGVIITGYSVEGTMAKQIMQEPDQIQAVMSRTTAGARRGPGGESEKVLIPRRCSVAEYSFAAHVDGTENREFIEEVAAPVVILVHGEQHNMMRLKSKLLSLNAGKTQKVKVFSPKNCEELRIPFKQDKMAKVVGKLATIPPPTSLSSPTQHQQQLVTGVLVQNDFKLSLMAPEDLREYAGLNTTTITCKQRLRLTAAGVDLVRWGLEGVFGSVEELPEMRKAPAAKDGAVANGNGTKPEDGEDQEMQEAQKHQEQEEADEEVAHPVAAYLVMGCVAVRYRSDGEVELEWEGNMLNDGIADAVMSCLFSIESSPAAVKRSASAHTHDHAPPPLPKNPHANVSAPERLERFLMFLEAQFGADNVNPVAEPRLPPQTEGGAAEDGTTSKAIKADVDGEGDGGDTSMDVSDDEAQQKKLAARRQAEIERLHKIGIPVPGIRIKVDKMEAVVWLEDLEVECSHKAFADRVRRVCEHAAEVTAPLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Q6</accession>
    <name>A0A1B7Y2Q6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2 m phase checkpoint control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154813.1">
        <property type="nucleotide sequence ID" value="XM_018305389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Q6"/>
    <dbReference type="GeneID" id="28869496"/>
    <dbReference type="KEGG" id="chig:CH63R_10415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10415"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="595" mass="61243" checksum="345B38B26F3D6DD8" modified="2016-11-02" version="1">MSEFLGYEDLDGPSLRNLARTSLLTTDLYRSRISLISKSDIRYVGVLHEINSDESTVSLENVRSFGTEGRRNRPEEEIAPSDQVYDYIIFRGSDVKDLRIEDHPGIKENKPPAMPEDPAIVNARPRPGQGPNNQPPPAPGFGQPPFQNNFYPPPGPWGPAPGRGGPGGPGGPGGPGGPPGAGMGGMPYPPPPGWFPPGPPGQGFPPGPDQWNNYNNYPPGPRGPPGPPGPLGPGGAPGQAPENRGTPGPQDVKPPPVGPAGDKQKPATPAAQGAQSEPKPAPPPGFQQAPAPTPPVESKPSAAEVKATAASLNTTGPSKPVELPVPTGPKIAARVQPAVPLAGSMPKAFPVPINDSNATQAVPKSAAGPTAASVRDATEAAKAAVALAMANMNAGNATVPTAPQGNGNAMDNLTKKVNEMRVNAARTTQPGGGRGRGRGGRQGQTKVDVPDADFDFAQANAKFNKDDLVKEAIAGSPLGETPNNGPVVETPVPEVTGANPPVAYNKTRSFFDNISSEAKDRADNNGQKPGGREWRGEEQRKNMETFGQGSVDGGYRGYRGRGRGRGRGGYGGRGGRGGGFRGRGGQGAAASPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y321</accession>
    <name>A0A1B7Y321_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154927.1">
        <property type="nucleotide sequence ID" value="XM_018305503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y321"/>
    <dbReference type="GeneID" id="28869610"/>
    <dbReference type="KEGG" id="chig:CH63R_10529"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10529"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="112"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="469" mass="51506" checksum="32FD19A72B73D276" modified="2016-11-02" version="1">MELRHVTTAPFLLCSRSVSTAPLVVEKGVGTAAPSTLAALPTPVLMRSLLVAAISSKPMLLGPSLSVLSFLTRPNRGYFTDVDRNPVLHALLKGVFYKQFCAGETPREAKDTMRHLRFMGFRGTILTYAKETIFDAKTNTEHGLGIDSEEDAAKNGHCSTIESWRKGALETVDLLSDGDQLALKLTGAGPRVTEAFAARRLPPQQMMDALNEICQRCKDRGVRLLIDAESQHFQWGIFLAGMELMRKFNRDAGRATVYNTYQAYLKSTPDTLAGHLEAASREGFTHGLKLVRGAYMSTDERSLIHDTKRDTDEAYDGIAQGALRRRIGEFGAPGGKPFPSLNLFLASHNKRSVVAAHEMHRQRLADGLPTVPVGFAQLQGMSDEVSFSLLQMKEEEGGGTGGQGRDASPQVWKCSTWGSVGECAAYLLRRAVENRDAVSRTVDEYVALKTEVGRRLRSRFGRSRQSVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3F5</accession>
    <name>A0A1B7Y3F5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155013.1">
        <property type="nucleotide sequence ID" value="XM_018305589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3F5"/>
    <dbReference type="GeneID" id="28869696"/>
    <dbReference type="KEGG" id="chig:CH63R_10615"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10615"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="206" mass="21778" checksum="DDE5FEA238428C04" modified="2016-11-02" version="1">MKIEVDTSREVGNVQSPPASRVQAEASETLRSYAEVGSDLETSDEDGAYRSNDDCVREQANAGKSQLGPQGYSVASDMNSSAVDVEDSNESSENYHADETSDDGRGSDDDDTGVENCQERVVLREFPGSPVARDTVLGDSAHAPVGSLGGLKEPQTGGFSLPTPASDHASDSGKGGQIVTRERKRDFGTTGGVCENLKLQYTRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3U1</accession>
    <name>A0A1B7Y3U1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155190.1">
        <property type="nucleotide sequence ID" value="XM_018305766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3U1"/>
    <dbReference type="GeneID" id="28869873"/>
    <dbReference type="KEGG" id="chig:CH63R_10792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10792"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="277"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="63747" checksum="5E9336973FAD23CD" modified="2016-11-02" version="1">MTTSNQNVDSLDSLLDFSEYDNMSYQSPSLSPAVTSKNTFTRPSVSTVATPTMPSASQPLTGPSHQYDLYKQQTGIVPGALASTLAVNEVNPHISGYNSSYGMEYLGAGLSPENDLFDFNTSPSQNSTGLDMDMEFESPPDSQYFFPNPTVNPSAIAGQESPVVPSQQSNVGRLWPGMHSQAALAKAQAQQRQQQQIIQQQQQRHQQMSNKPRTKSQQPTDPIVEQKITQLLNSMRAKPAQEGDSPTPLMNLPRSKKDEEDMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYITQLEAEIANKVSENGDLRVHNRALQDENKRLQDLTRMLLASPSFSNFLDHLSTNPQAAPQPAAAVKVERQPEQRQIPKDINPYANQGQQQQQQIGMAMVPEQNMDFAMLNIDNDAYNFQPQVFAVLETPDVPVTIDSNVLSGKSSNFVGEKFESDDEKIDIPAIEAPKTLAPEIPSQTPAETEVFDDEFENDPEFALYHSSPALSAEGPVELDTEGFSHIDIFGGVETEKVLARYDLVDASEEEQNACVAMARVQRLSASLEPVLARLESLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3W1</accession>
    <name>A0A1B7Y3W1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155173.1">
        <property type="nucleotide sequence ID" value="XM_018305749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3W1"/>
    <dbReference type="GeneID" id="28869856"/>
    <dbReference type="KEGG" id="chig:CH63R_10775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10775"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="72" mass="7935" checksum="B03DF49EDE0AFD79" modified="2016-11-02" version="1">MYNRRCAQDASPESVSTFTYYLPTGAAPVEDMDGKVPGRSMIDDEHCRSRDLSLMQPPCPPSLHARTYAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y403</accession>
    <name>A0A1B7Y403_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155213.1">
        <property type="nucleotide sequence ID" value="XM_018305789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y403"/>
    <dbReference type="GeneID" id="28869896"/>
    <dbReference type="KEGG" id="chig:CH63R_10815"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10815"/>
    <dbReference type="OrthoDB" id="4827701at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="362" mass="40538" checksum="85613740CC2A4B83" modified="2016-11-02" version="1">MPDFLRRVSADRRSQQPRPEVLRPPRHVPTTNQQVVRVCPQCREVPLGPGPVVNGQPTYPVCEECRQTNIRQQVLRGIAAEALVELSRRAVVHSPGRADREESGPGRDLSESRPVPKPTQGFLCLRCKRPGVPSAPGRRRCVECICVLVAFGPDKGGQTVEDEPEHGSWHTCNGCFRNQVPPGEGKCHDCVDRLASEAQASTTLAAAAATCVICESEPAANEKAYCNNCEVEGSRGMGASVMLDTKQCTACGEEVDNTADDGLCWDCRMPPRSPDERDDEEWLENEIETWEDGPSRQQQQSGRDKMCGCLRNAARWGRMLCNDCYEALRSVDRRGWADWKRRNWPSKARRVARRREEQSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y458</accession>
    <name>A0A1B7Y458_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155355.1">
        <property type="nucleotide sequence ID" value="XM_018305931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y458"/>
    <dbReference type="GeneID" id="28870038"/>
    <dbReference type="KEGG" id="chig:CH63R_10957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10957"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="228" mass="24556" checksum="0AB6AC7A9C1B7637" modified="2016-11-02" version="1">MRTHDSVQLQLQLSISQIASSELTVVSIRIGPRHTEFEAKNKNDMVRTDTLSISLSISLALDQKAQGLSTLSVGVEHVVSGLGNAHAPDAHMIYVPILRATGGSVSQPGATSEIPRYAPPLSQHGIFRLARGSMHELAIFHSSSLSLLFQAFMAEIADLPWITAARNKLSMTEPSLHAAQWGNPSHLSKTGRPSNSEHIRLLRWAPPASTGAHPPEFHHSGLHIGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4A5</accession>
    <name>A0A1B7Y4A5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_10972</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155370.1">
        <property type="nucleotide sequence ID" value="XM_018305946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4A5"/>
    <dbReference type="GeneID" id="28870053"/>
    <dbReference type="KEGG" id="chig:CH63R_10972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10972"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="13">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="396" mass="43829" checksum="89343FB26F6F3295" modified="2016-11-02" version="1">MVRPSTPPPNPASAPRPAATPPTPAATRRMEESRLRAKAIRDRRDAELAASGAPSAPKTASGFVSTQDVHITKAGASQPSDLSRKRPHSSISTAADPRQPHPATNRDARDTQAAPRPARNFAKFVDFNMSAMTDTKGGFLTAEDDPHNTALVPKTKPGGGGPPQEEKPKGMSSQEWERLQLLRKLRRQKAGPFEPGLSVLADDTARKLCADCGSLEIDFVWDEVFGVRVCHACKDAHPDKYSLLTKTECKEDYLLTDEELKDPELLPHLSRPNPHKSHWHDMMLFLRLQVEEYAFTTKWGSAEKLDAEFARREADKKRRKEAKFREKLNDLKRKTRTEAIRRQQATVAAGAGPKGFGDSVGGGRHVHDWGRAVENEDGMTVKTCNGCGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4H3</accession>
    <name>A0A1B7Y4H3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxyneurosporene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155402.1">
        <property type="nucleotide sequence ID" value="XM_018305978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4H3"/>
    <dbReference type="GeneID" id="28870085"/>
    <dbReference type="KEGG" id="chig:CH63R_11004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11004"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601316" evidence="1">
        <location>
            <begin position="17"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="239"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="370" mass="39895" checksum="EA5F5CF1C390C40D" modified="2016-11-02" version="1">MHFSTSGVGIFCAVWAQGQLASAVATQSYIPFKLINSSTIAEITSQPGNLDGPKLKPGVNETSFDWWYFDVVSTTSKNESLTIVFYNSGPSSLGNPGGPLSIQVTGVFANGTAFGTIADATCGATMKNDEDGISSVWNGAGASFTGTSLDQRGVEYTVAIDNPTIGINGTLTLKSVSLPHYPCDLNKPGVSQQIIPDVFWSNAVPDAVATADFAIAGSPLRFTGNGYHDKNWAATIFSDTFNTWYWGHARLGPYSLVWFDVVTKDGREHFSSWITKDGELFTQSCQPNSVVVRPWGQNSEFPPTPKMPAPSGYMIQYDLGGGKAFVANFTSENIQLSTNTYKRMTGPIVGGVEGHEQYSGRSLCEQFQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y506</accession>
    <name>A0A1B7Y506_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155640.1">
        <property type="nucleotide sequence ID" value="XM_018303617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y506"/>
    <dbReference type="GeneID" id="28867724"/>
    <dbReference type="KEGG" id="chig:CH63R_08643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08643"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="94"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="96"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="882" mass="97400" checksum="FC24FAB5C47FF8B8" modified="2016-11-02" version="1">MADPFATELPPVLPDDIEFDFSQFCLFPSAEDVYEDVSASHNQAQPTSGDTQQPDEPMASPSSSISGGVMLSDVVENGNLDPKTADDTNASAAETTSKAGSRFTSTTIRVLRAWFDNHERYPYPTPEEVERLQKRTGLSKQQLTNWFANTRRRKRFCANGTASPRVPSFTEPGSGPIDIPARRPTPMPFEQMNPLQRWEHSPPEHEPALVSDISRAVAASSSRRSGLSNRSRSSARSSDNASSVSSVGTSRSSRGSRSNGSAYSYGSNASPVPTHGIRKDSSRRRRRAMAKGQRDKPKSLMQTRNLYQCTFCAETFKTKYDWQRHEKTLHLSLEEWVCSPGGAIEIDPERGILCVYCDEVGPDQHHLDGHHQAACSDRPLDERTFYRKDHLRQHLKLVHRTKKMTKCAEKWKVTTDAIRSRCGFCDAALESWSHRGDHIADHYRSDGITMSDWKGDWGFEPSVLAKLENAVPPYLIQWEQSAPVPFCANDGPADTCPSAYELLKLELEYFVRNFFEAHEALPSDDDLVYEGCTIIFGSQLFSPDLDPAASSWLRDLFMDATEIAARARLRPMNQLAKLRMSQLRIKGKADIFEDCELESQLCRHLREHTSLGLAVSDAELQQEACATLYRVEASSTNPSRRFAGFLVRLISESTGWIESLRQRAEQFVGDPYLDFGPVQATLESLADDPMNGLFGGGLGGLGQMTLGSGSQPVPSGTGDRMATGGGGGGGGDALASFLEPVMYSQPPGAGPGLMPDDLFKDGASASASASVMGAQDFYSRLQTSKTLFAGSGFSLGWTEQPSAKGIPFFLNDPNRYGRLAGELSRFVASSMSPNNPNKHVPTDDEIRYQARWIFYDDDDPWNQTPADTPEWLAEFKKQVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6B4</accession>
    <name>A0A1B7Y6B4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156006.1">
        <property type="nucleotide sequence ID" value="XM_018303983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6B4"/>
    <dbReference type="GeneID" id="28868090"/>
    <dbReference type="KEGG" id="chig:CH63R_09009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09009"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="726"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="499"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1114" mass="120729" checksum="7F5986190705F641" modified="2016-11-02" version="1">MSFSNSSGGTLTVPSPTHAHHVDVLASSVRSLRRSLSRSPSKFSLARTDSPSSESSHSGSHTPVQQQSPCRRYTPTPTPPSSSHNNNTTAYGELFQSQTPAGLPPSMTSTTPFSSPPSLATPFRPSVRLSLRSAKSSKVTGSPSRPATRLRTSPKSPLKRALNATTESGVNSTPSSSSNSVASGQENNQSSAQQSPHSRSSTQKASRHSLHLDVSGHAQQTNIFKHLEAQGDPQGAPGSGALKRSDAIMNLDQASLGSPVAKRRSLHGISSFSQNTSDFNIFDNTSSTPAKTGFDIHDEASREREYELFGSSAAAREPLPSPTPPPQIPRRTGSLRRSTLQQRQHDRSSWGRKSGANHLAQMGGEFSTPNVKNRPRLSMDQFLPPQIPRDSPFTSNGPLPNPSAHPVERHSHQPHPLSKTLVTSTSGNSLEEQNNSMPPPYVFERPRAPLNFAKSMPYGSSRPSFMQDEGENVTPFKSAKPWAGAFMSTGLVSKVNRNPEEDNKLTMPDTPCKKPTNGFATFPPPPGSAIKKSNRYSFGGMPSTPFNAPGAPSRSTFGNPGKGLGIFQRLGSRHARRGSVLSLDEDKKFSLDTNFNVGLGVENDAPPTPTKQGLTPSFSNLSEQSIESPSAKRTLPPPMSAVRPMISRESTASPVEQRSPRTPSTHVVLPDASCLSISNPAESKSAATPVTPSGRDSLQSTTTQLMTPVNAGRANSDADDSLYSRFDKVEMIGKGEFSSVYRVVKAGYSRASFLSVFSGTPTKNPRESPEPDRIYAVKKARRQFTGPKDRLSKLREVHALQALTHADHVVHYVDSWEYNQYLYIQTEYCDEGTLDKFLSNVGRKGRLDDFRIWKVIHDVGLGLQSIHEAGFIHLDLKPANILITFEGILKIGDFGLATEWPAAKGVDAEGDREYIGPEILRGDFNKPADIFSLGLITIEMAANVVLPDNGPTWVALRSGDLSEVPSLTFSATTATSAHRDAAGVPTMQSFDDPLLGQTSAPDISLHLGAAPTRVSVVMDDESPFITRKRTELRSPPDFMSDPFHPSSLDQIVRWMISPEPSERPTIQQLLSTPSMTWVAQRRRSAATVFEGVWGPSESTALPTLVDEDTEMMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7K8</accession>
    <name>A0A1B7Y7K8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_09537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156534.1">
        <property type="nucleotide sequence ID" value="XM_018304511.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28868618"/>
    <dbReference type="KEGG" id="chig:CH63R_09537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09537"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="818"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2092"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3387"/>
            <end position="3461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1290"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1963"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2058"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2894"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3739"/>
            <end position="3774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4095"/>
            <end position="4120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4435"/>
            <end position="4463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4476"/>
            <end position="4495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1294"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1973"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2064"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2081"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2896"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3739"/>
            <end position="3749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3765"/>
            <end position="3774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="5159" mass="561714" checksum="25E6B88CB9AF538C" modified="2016-11-02" version="1">[encoded data, 5159 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8C2</accession>
    <name>A0A1B7Y8C2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sh3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156775.1">
        <property type="nucleotide sequence ID" value="XM_018301997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8C2"/>
    <dbReference type="GeneID" id="28866104"/>
    <dbReference type="KEGG" id="chig:CH63R_07022"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07022"/>
    <dbReference type="OrthoDB" id="5243589at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="52877" checksum="132C267A417C7F38" modified="2016-11-02" version="1">MAVDVEELIITPFREVVERGKEAVANAEEAQNDDPEQAKQMMKSAMAITKEGERALKRLQPLWDSQVEKHGDTFKDIIADNDDIAEKRRVLEELLYDFEDFLDLESFDSSKFAEVQTAARSFALDVLDSIKRMKIETKTPTTPVSAFPPLPPLPPLPPLPAQPQKLASQPGQAPPSRSGSQASANFSLFPVVARQQPKRTATRSSHGSSDGATPRRNSSVARSAASDTRSSHVYSSSNQDTTSTTVSAAINGREEYRSSSPDVLGEELNQLRIITSQEPPPHPWTSNWIEEQTSVPRPRRHVRGSIPEDSAVTNHTLSDSTTAARFNKYGLDNSITPQSSVFDPTSPSTTNRTSVNSDSPTQSSSGPSPKLPVSEMRLSSLAAIHFGPTVSMGLQPQGHFSDGLMLADEQAVSETSTQRHRSISTLAKEEDCSIGPKSSFHQLKGFCEGAQSFRRGGYWNGLKQAMAYVSNNSSPVSVVRRGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9K4</accession>
    <name>A0A1B7Y9K4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157250.1">
        <property type="nucleotide sequence ID" value="XM_018302472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9K4"/>
    <dbReference type="GeneID" id="28866579"/>
    <dbReference type="KEGG" id="chig:CH63R_07497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07497"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="110" mass="12265" checksum="A902A4B91DBEDA07" modified="2016-11-02" version="1">MYATGITRDPSSLFKRLNLQMQEHYVVCFTCTHCDEAENAPTTAGATSIQWCLYYPWVFDSLPLTLPMLEGDIDVAKAGSYSNTCSIRGFSKGVYAACLERAVEILRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAG3</accession>
    <name>A0A1B7YAG3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157600.1">
        <property type="nucleotide sequence ID" value="XM_018302822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAG3"/>
    <dbReference type="GeneID" id="28866929"/>
    <dbReference type="KEGG" id="chig:CH63R_07848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07848"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR09083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113496" checksum="25B8950A76740E4D" modified="2016-11-02" version="1">MSLRKATGHKSKPAAPFPHDPDADTVALALEPLPLLAPAASSTNDSPADAEADVANLSTPSSSDQTASDPYNTTHHPRSRPSTLRSRPSALSYTSSADEHGDDTTGPILTSPVPQLDDGAMPSKPSLLRSARNDAPSYGAVSQEPSRNVSPTGIDSRTGNAHPLRYVSDTSKSTSSRFSASSKRESSRLSEELDAAALATGLEGRFGVTQAPVTTNMLEDAKSDAAEDEIQYDDYTGSEPDEDPVDNSPHEVVRASVPPTDNVTLSINTPRMWILSFLFSVLGSSTNLFFSLRYPSVAITPVIALLLVHPLGLMWDYALKYPSDPPEEFVDGVLVPEGANDRLPPRRSLNRLRRWLAQGRWNEKEHTCVYVSSNVSFGFAFATDVIVEQSKFYNQEATIPYQILLTLSTQILGYAFAGLTRRFLVRPSGMIWPGTLMSAAMFGTLHKEENRIADGWRISRWKFFYLVWFGGFAFYFLPGLLMPCLSYFNVITWFAPKSVVVANLFGVVSGLGLFPLTFDWAQITYIGSPLLVPFWAAMNVIGGLVIVMWLIAPIAYYANVFYSSYMPILSSAVFDNKGEVYDVSKILTPEFLFDREAYSKYSRVFLPITYVLSYGVQFAALAALLTHTACWHGKDILQTWKTAVAEARNEGQAVYQPVSGSSEHISPQRSLSGSRGISRSSSNLEGMMFREDVHCRLMKRYKDAPLSWYLTTFVTMLAVGIFVVEYYPIHLPWYGLLMSLGICAIFFIPNGIIMAVTNQHSSIYLICQLICGAVFPGRPIANMVFVTYGYISSAQGIKFASDLKLGHYMKIPPRIMFSVQMVATIVSSLTQIGVLNWMFANVKGICTSEAVNGFTCPIARVHFNGSILWGVVGPGEFFGPKATYRGLVWCFLIGAITPIPLWLYARKKRHSIVRKINLPVVFGSMAWIPPATGLNFSVWAVVCYVFNYLVKRRKSAWWAKYTMTMSAALDSSLAFGIVVVFFGFVYPGHMKGFKWWGTEVYKQGCDWQACSYNTVPEGGHFGPDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAX3</accession>
    <name>A0A1B7YAX3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157547.1">
        <property type="nucleotide sequence ID" value="XM_018302769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAX3"/>
    <dbReference type="GeneID" id="28866876"/>
    <dbReference type="KEGG" id="chig:CH63R_07795"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07795"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="59" mass="6466" checksum="0A82BCECE89C9E6E" modified="2016-11-02" version="1">MAFDPGVTLPNLTWGEEVLSSIPSLTELTEIGIVRSSASFGFSTLKARWLSSPSIRHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBI6</accession>
    <name>A0A1B7YBI6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_08152</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157904.1">
        <property type="nucleotide sequence ID" value="XM_018303126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBI6"/>
    <dbReference type="GeneID" id="28867233"/>
    <dbReference type="KEGG" id="chig:CH63R_08152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08152"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="397"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR09387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="806" mass="87254" checksum="05C63FBC95209319" modified="2016-11-02" version="1">MSRHQAVRNLDYDEALDEYEGEDFDDENEADQLSPEDRDAMNVGTATVQSALGPDADKVTAQQIQDALWYYYYDIDKTVSYLQKKFIAPPPAPKQEPKKAKDDGFGLESMGGEVTDYDMATVPVYPIRQTVSLSPSSFFHGIPWMNVPSNRQAVLVPPRPLPGGLLGGGEGPKLSKLQALAAARKKKTATEAKNPDDKVDRAEKRMSTLAIDESSKGDQRPGSSILAKRQKLAADSASGAQAATLVSRPRQDESAPGPSGMDVDDAPSPGNIDEAEVDCLVVPPTRPSAFAQTLFGSAQNSAAASQTYTLPYMDSSTFVPSAFSQPSPDDIVLAAQAKAGTKFDAAAAKSATKKVVTKPTGSQTPTGEMKQLQLDDSTAPKNKKLNVLKEFEKSENKRSASFVVVGHVDAGKSTLMGRLLLELKYIEQHLIDRYRRQGEKMGKSSFALAWVMDQREEERERGVTIDIATNQFETEKTRFTILDAPGHRDFVPNMIAGASQADFAILVIDANTGAFEKGLKGQTREHALLLRSLGVQRVIVAVNKLDMVGWSKDRFDEISEQVTGFMKGNGFQLKNVTFVPISGLTGANLAQRPDDEALSWYDGPTLIEALEDSDPMARALEKPFRMSISEIYRTQQSQLTVAGRIESGTVQNGEALIIQPSGEPASIRSIEVDGEAQDWAVAGQTVNIGLYGIDPIHVRVGDIISTKAAPIETSDTLTMKVLAFDHLMPMPVDVHRGRLHAAGRVEAIPAVLDKLTGSTVKKNPKIVQPGKVARVVVKLESKVPLEAGQRVVLRSGGETIAAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBZ5</accession>
    <name>A0A1B7YBZ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LolP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_08250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158002.1">
        <property type="nucleotide sequence ID" value="XM_018303224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBZ5"/>
    <dbReference type="GeneID" id="28867331"/>
    <dbReference type="KEGG" id="chig:CH63R_08250"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08250"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF77">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR09485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="493" mass="54873" checksum="87AD9B60287620AC" modified="2016-11-02" version="1">MPSFSLSLGSLTVYAALAFFLWYTTSAVYAWWGLRRVPGPFLASFSYLWVAWHIVRGTVDVGHKSLQKYGPLARTGPGYVVTHDPEVIRRIMAARGSYGKHAWWGGARSHPTEDSILSTVDMARHDEIKAQTANGYNGRDGTDVHGRVDRQVERLVGLVRRRFVSAAGARRVVDLTDLMRFFTLDVTTDLSYGRPFGFLDEGKDLFDFNRTMDAYVSAMTLGLDVPFFRNLMRSPLMAFLLPKDTDNSGAGKIMGLIPLGGAYRGPPNHGSFMRHGLTQAQCEAETFVQIAAGSDTTGSLLSTTMLYIITAPRVYQRLKEEIRAAVAAGSVSYPIALEQAKKLPYLQAVISEGFRMRPPVPYGAFMSVPPRGDTIHGVYLPGGTGVGFNIVAMMRCAETFGVDVDVFRPERFLECDDDARRGMLRQVDMAFGTGRLLCAGKQVALLELNKVFFELMRAFDFQLVDPRKGWRERALVVSTQNDMWVTITEDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDK8</accession>
    <name>A0A1B7YDK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn 2cys6 transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_05819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158644.1">
        <property type="nucleotide sequence ID" value="XM_018300794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDK8"/>
    <dbReference type="GeneID" id="28864901"/>
    <dbReference type="KEGG" id="chig:CH63R_05819"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05819"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="195"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="712" mass="79347" checksum="49E598BD0E4DD9A2" modified="2016-11-02" version="1">MDGLGIVSAGGATPVSPASPTNARHAPNGPPKRKHSSMALDSSPGSNVGHDDDNGEPDSKKRQPGVKRACNECRQQKSCSRCNRLKLECKIESNFKRIGKRSKHAEMEKEIDRLRRNIARAQNQGYTVEDDDHDLQSPIATSVYTHTRNPSLMGSDEAVSSLLHLKRGGSYSLPRYTHELENVRLTEESVNQLFNEFFAYYHPFLPFLNPQQTPDQYFQQHALLFWSIISVAARRYSADPTLLTSISGPLTRLLWSTIGDVPSSYFVVKALCLLCTWPLPTSTTSADPTHILCGVMMKVATGIGLHRPNHSQDFSRVSVDLNKEQLHDRVSTWAVCNVVAQTIGTGYGQPASTLYDWTLAVRRGEDGPFRLTPELEARLQIERFCDKVSKEMYSNASDPRGVAGDEHRAMLMRVYRKDFNELQAAILSQHLGPIVNLHMRAAALHLRLAGFFDSSTTPGYIDDLMGLWRATTSFLDNILEVDKVTSPGQNSPGQILLYATNYIQQMLIAAGFALLKLMRSFFAKTIDFDRGRNLFHQTINAIRATSVVNNDLQWRLAELMVQMWNGARLDNNSTASYDNDDSPLLIDDTLQLKVRCRHSMSLVFDSVWRWREEYQAQGRGSIDANESSASSTHLDSTLMPATQGLQASSLLTTNGALTPSHSGGVGSQAPSNSMLSGMNYGETNYDFFDPQHWMLDGLLDFNYNFVQPLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE30</accession>
    <name>A0A1B7YE30_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158799.1">
        <property type="nucleotide sequence ID" value="XM_018300949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE30"/>
    <dbReference type="GeneID" id="28865056"/>
    <dbReference type="KEGG" id="chig:CH63R_05974"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05974"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="401"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="678"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR10282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="832" mass="92472" checksum="91E711F881A622B4" modified="2016-11-02" version="1">MAHENRYDDKMSDERTPLITNVYVGAPRRRYPNHVLRRFCTVALSSILIFWSIFFVIALFVDEPPRHHKHHRHGWSWTNDVNRGPITHEEVQKILFEVPSSEKAEEWSRYYTAGPHLAGQNYSQALWTKEKWESWGIQSDIVSYDVYLNYPIDHSLSLLSKSKDGEESSWKVEFKAALEEDILEEDPSSGLEDRVPTFHGYSASGNVTGSFVFVNYGTYQDYEDLVKANVSLEGKIIIAKYGGIFRGLKIKRAQELGAIGALLYSDPGDDGKVTEENGYEAYPNGPARHPSAVQRGSAQFLSHRPGDPTTPGYPSKPGVPRAPVDDATPSIPSIPISYADALPILKALNGHGPSVTDFNKYWNRNLGLKYKGVEYNIGPSPDDVVLNLYNEQNYTTTPLWNVIGIVNGTIPNEVVVIGNHRDAWIAGGAGDPNSGSAVLNEVIRGVGIAVASGWKPTRTIVFASWDGEEYSLIGSTEWVEEYLPWLSQASVAYVNVDVGVRGPHFNPSAAPLLHRVLREVTHLVPSPNQTVPGQTVGDVWNGHISTMGSGSDFTAFQDFAGIPSLDFGFGGENDEVVYQYHSNYDSFHWMKEFGDPGFVYHRTMAQILGLVVAELSNVPVIRFNATDYAHALTAYVDQVEAKLSAAEPTSDEELFRMRASVVAADADARGSLSQFRASLQILRTSIAALREKTEKLDATASWVDWELKSDIPWWNLLRKIKVALAFVWVNKSYKGFERHFLYPGGLDGRSWFKHVVFAPGLWTGYSGGQSISFYQFAPLFCLVVQPRDKNTDIVTAAVFPGLQESIDAKDFNNALKWTGIINECIASATKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEB3</accession>
    <name>A0A1B7YEB3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duf1776 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158886.1">
        <property type="nucleotide sequence ID" value="XM_018301036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEB3"/>
    <dbReference type="GeneID" id="28865143"/>
    <dbReference type="KEGG" id="chig:CH63R_06061"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06061"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="53611" checksum="CD311CC6FFE74E34" modified="2016-11-02" version="1">MSADDQQFLDVLSSLPNHIRRYSDDLANLINPHVDKAAQAVRETLASTEWLPDSVRPSPPVRHVPIEVIAMSRYETIHTWVKEHKLLTGAVVAVVGFVAYRSYKSSRFCKKTRRAKRARNGGRLEVVVIAGSPSLPLTRSLSLDFERRGFIVYIVCNAEEDESMVHSLSRPDILPLTIDTTDPPKAGAAIDSFAQYLQSPHAPAPRTRPNHLQLKSVILIPSLNYQTSPIATIPPSSFADLFNTHLLHPILTIQAFLPLLTTRLSPPEEKWTPPKVLVFTPSIISSINPPFHAPEATVSSALSAFTEVLTAELRPLGIPVTHMQLGTFDFTGFQPAKHTHPSQRGLLEGGPGIDADATETLMWPENARHAYGRNFVMQSTSAISAGRIRGLKGSSLRHLHNAVFDVIDGSITSGTVRVGLGASVYGFVGRWVPRGLVSWMMGIRRVDELSAWQTSSYNGSLDGSENEDGQDFVAVPDEKLDSNVWKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEG3</accession>
    <name>A0A1B7YEG3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158936.1">
        <property type="nucleotide sequence ID" value="XM_018301086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEG3"/>
    <dbReference type="GeneID" id="28865193"/>
    <dbReference type="KEGG" id="chig:CH63R_06111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06111"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601576" evidence="1">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="44116" checksum="F110224D1409661E" modified="2016-11-02" version="1">MIHPLLPLCCSYLVCALLLPAVSLHGVRRAGRMWTRYVQCTAVAQSVRTVTTSVKQRRLHVGKLSPSCCDIAVEHVPICHIWHIPHICHILHHRILQIRHIYHIHHVHHIRHYCSNPPNLYQEPKTPLIMSVNSVISALPAYKTLSAFVYSGTTDPKALDDTVQEFKDLAKKAESEIEDFLWDTYNAIFAVASQTPAEKQGPLLDFLQRLRETTVTASDGQPLKLSNQVVWKDLPTFGWVARDVWNFDALDSSASKEDKASWDNLTAFVAQLTAHADLADPQDPFDFSLYGLWALRTAFEENHPADADVPAAVKQAYLWIKYSGDALQKLSAKPRNFEGKSGQAGAKFGDREWKGLNEERWAAWTEAFASAQASLTDDEVKGLAGKAAESMKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEH7</accession>
    <name>A0A1B7YEH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_06148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158973.1">
        <property type="nucleotide sequence ID" value="XM_018301123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEH7"/>
    <dbReference type="GeneID" id="28865230"/>
    <dbReference type="KEGG" id="chig:CH63R_06148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06148"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="197" mass="22398" checksum="274B9754AFB09B5B" modified="2016-11-02" version="1">MPTDFDKQSYWGERFASETSFEWLTPSATLLSIADPYLADLDDSARILQLGFGTSDLQNHIRARGFTDVTNVDFEPLAIDRGRVLEKQVFGDVAMRYLVADVTRLQLPDKFDVVVDKSTVDAVSCGGVDAFLRMAEGVRRHLRDGGFWISLSYSFCRFDVEGLPFDVEVIAKIPTPKLKPHDPDVYHWCYILRPKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFF6</accession>
    <name>A0A1B7YFF6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159418.1">
        <property type="nucleotide sequence ID" value="XM_018301568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFF6"/>
    <dbReference type="GeneID" id="28865675"/>
    <dbReference type="KEGG" id="chig:CH63R_06593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06593"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="189" mass="22206" checksum="A094577C7CA122C6" modified="2016-11-02" version="1">MATTFHLFPLLPWELRIRIWKLISTPRTVMAWAHDYGRPHPPVPSVVQTCRESRHHSGYERLFIEDRPPFYYIWANLTIDTIHIFEHRLPLQFAGKHRIRYLCLELVHQVDPDNEPFRDGWVDVYSNALIDYVAVRSMVVVSFNDVSAWGGHVHLYPWPCPLSRVMLVQDGFEKQISAQELMDSLTPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHR1</accession>
    <name>A0A1B7YHR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EC9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160208.1">
        <property type="nucleotide sequence ID" value="XM_018298962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHR1"/>
    <dbReference type="GeneID" id="28863069"/>
    <dbReference type="KEGG" id="chig:CH63R_03987"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03987"/>
    <dbReference type="OrthoDB" id="4851323at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601683" evidence="3">
        <location>
            <begin position="19"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="690" mass="79858" checksum="573E91FAD9FF99F0" modified="2016-11-02" version="1">MPSLKLLLISMLVSGSLAAPLAARFETNKTAAGLFDENHRTSLETREEDEAKDSADIQARKIEVSQDFADLETREEQEVGRDFSNGLYSRDIETPEDAPVLDTRDLKEVSEVYSTYQSRDVEADEEADHLEARSLDMDEELANVETRNENQSKKPGSTTRKATSSTKTRANDKKRVVDAKPPQRPGQAANVNGPVTYTTFVVPKVNPDQIGGFLDFKTTKVQSRDNVDIHARIQEMQETIRQLQQARDEAVSRIQGGYYAKDTSGDRIQDLQTERQRLLDVISQAEADKQQAGDRIAELQQMKNLGTYDNNAIDDEIRDQQARRDLADQIINEAQADKAVRDQLIQEQELLRKQDDATIRGAQGYKDQYEAQIREEERQRELLRQKLQPLSDTDRRNELRRLWLQDLNEADRKRVLALNDVDRQIEIDRLRYLACPETERQRLLRLDANQRLVELDRLQLQGLSKTEKQYQRGLEIERLRLQSLNDNDRLNEIRKKQDQLLRDQKLRDQLFRDEKLKTSNAEAARKLREQQLRDEKLKTSNEEAARKLREQQLRDQKLKTSNEEAARKLREQQLRDQKLKTSNEEAARKLREQQLRDQKLKTAKEDATRKANGAKDELARKAKESQRLQELKESKEDATRKANNAKDEAARKLRETKVNRPNPVSNPVPKQPPRQPSRQTSKPSKKKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIT8</accession>
    <name>A0A1B7YIT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SNF2 family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_04044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160265.1">
        <property type="nucleotide sequence ID" value="XM_018299019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIT8"/>
    <dbReference type="GeneID" id="28863126"/>
    <dbReference type="KEGG" id="chig:CH63R_04044"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04044"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="366"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="707"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="788"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="956" mass="108416" checksum="BC73E0BB6CBDD625" modified="2016-11-02" version="1">MAATPAPRKSASRIEIQLPTAAGLRSERALRRSQYSMAPIKRKRSDNGDGDDDDDEEYSDNDRDASVARRLQKEENRRGSKTARLSDADLARRLQEEEYDMDEVNAPTASQQGRRSVTSAKALATDSEDDMSEDMSFAARTKPSGQGRSRLVKKKNISFAQPPTKKQKDLSFASDDEDELVGSMDEDDDFDLSSEKDDSDYDFDDNPKTSTSKGKNPVRETRSTASSSAQPPATSGPSRRDGQRQREEEDILEGQDDDLSSLSSYVTNVTDDASAAAAASTASDSDGRLQNAVRRQSRGRRALQRGSRRRGQLERDRLEQQHPELLTMWQELEALPPLRPENIAQPKQISRQLKPFQLAGVAWMIAMEQSDYKGGLLGDEMGLGKTIQAVSLIMSDFPCKKPSLVLVPPVALMQWQSEIASYTDGTLKTFVYHGSLSKAKNVSLKELKKFDVIMMSYNSLESMYRKQEKGFARKDGIYKEKSLIHQIDFHRIILDEAHCIKTRTTMTAKACFALKTTFRWCLTGTPLQNRIGEFFSLIRFLQVKPFASYFCKQCPCSTLDWDLDEDHRCRRCHHIGMQHTSVFNQELLIPIQKWGNRGEGADAFRKLRTMTDRIMFRRLKKDHTDSMELPVKEIYVDRQFFGEVENDFANSIMTNGQRKFDTYVAQGVLLNNYANIFGLIMQMRQVADHPDLILRKNGEGGQNTLMCNLCDEVAEDCIRSRCKHDFCRACARTWLAANDQPDCPQCHILLAIDLEQPEIEQNEADVKKSSIINRIKMEDWTSSSKIELLVHELHKLRSDNASHKSIIFSQFSSMLQLIEWRLRRAGITTVMLDGSMNPAQRQASINHFMTKIDCECFLVSLKAGGVALNLTEASRVFIVDPWWNPAAEWQSADRCHRIGQTRPCTITRLCIEDSVESRMVLIQEKKTSMINSTVNADDKAMESLSPEDMQFLFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKL3</accession>
    <name>A0A1B7YKL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161052.1">
        <property type="nucleotide sequence ID" value="XM_018299806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKL3"/>
    <dbReference type="GeneID" id="28863913"/>
    <dbReference type="KEGG" id="chig:CH63R_04831"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04831"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="393" mass="42656" checksum="399AF9A003C6C3CD" modified="2016-11-02" version="1">MASTTTTMTTTTDTTSHTGIAIIAINVILAVIATITCVGRFWARKLTGVGWGLDDWLALISLIINHAFCATTIEATVHGGLGRSIVDVMAEDPNMLVIFLKCVVVAEFCYGFSSPLIKLSLLAFYWRVFPTQFMQRGIYVLSAMCLGWLVAIFITNCLQCRPLSYSWEQTTNPGAGTCIDLVLYFVGNSIANSLIDIFTLVLPIRETLKLQVSSHKKVGICCVFGLGSLVVVASLVRFGSLASLYSIGVTDMTQQYALMWTATVVEIYIAIIGACAVTLVPVYRKMRYGTPWSTRDQKSNQVSSGTGAFAGTGGAGSRPGVHNFKRSANHERLTTGNDSEEYLHHGGGMKYSVSGATGSGDKSDALGDDLPMDTIVVQRDVTWEEERKEKQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKV3</accession>
    <name>A0A1B7YKV3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H1/H2 small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161162.1">
        <property type="nucleotide sequence ID" value="XM_018299916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKV3"/>
    <dbReference type="GeneID" id="28864023"/>
    <dbReference type="KEGG" id="chig:CH63R_04941"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04941"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="80" mass="8804" checksum="576E06CCC649287B" modified="2016-11-02" version="1">MEKSDKVETQQLEGETEEAQGDLVELGTMDVKAEFDEMVIWGHESSADAASDPYVRSIEEWLAAAESIHTYPSPETKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL18</accession>
    <name>A0A1B7YL18_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161248.1">
        <property type="nucleotide sequence ID" value="XM_018300002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL18"/>
    <dbReference type="GeneID" id="28864109"/>
    <dbReference type="KEGG" id="chig:CH63R_05027"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05027"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="864" mass="99312" checksum="5A77712B7730DF14" modified="2016-11-02" version="1">MGLMTTSDHGHKEKEKEGGGSFMDKLKKPFRELEEKLEGTHLHDAKVHIVHKKHQIGKLANLFNANHRHDEEHEKATDDKRAKIAEEHRFNSFFPERDGNLIKWYVDGRDYFWAVSEALEAAKETIYICDWWLSPELFLRRPPYFNQEWRLDQVLKRRAEAGVQIYIIVYREVEAALTCNSAHTKHALQALCPEGTPGYGNIKIMRHPDHNFMSNGADMTFYWAHHEKFIVIDYATAFIGGLDLCFGRWDSHTHPLADVHPEGVQNEVWPGQDFNNNRIMDFQNVQDWKQNELSKAEYGRMPWHDVSMGLVGPCVYDIAEHFVLRWNFVKRDKYKRDDRFDWIQLRGRLGDDEDLVGVQRPKHPVGEYLTHPLNEQSLHNLENKGTMHAQIVRSSADWSSGILTDHSIQNAYAEIISKAEHFVYIENQFFITATGDQQTPIRNTIGRAIVDAVVRAGKEGRKFRVIILIPAIPGFAGDLRDDAATGTRAIMDYQYKSICRGEHSIFEQVKKEGVDPKQHIFFFNLRSYDRLNKTSSVDKREKDTGVKYAEVQRAQAEEVMGTGIHGSNDPTEKARDEHMGGKAEQTGAGREAAAASALDAKRRFEASLGDSQLKGEFSVAHHAMANSGSIEDEPWDDDDPETEVRNWIQEELYIHSKLLIVDDRIVVCGSSNLNDRSQLGYHDSELSIVMEDTKRVPSTMDGKPFEAGWHATSLRRYLWREHLGLLPAQDLDGSEDPNARPPGHSPNDAWDRDETWKFVEDPMSDDLWNMWTENATKNTDLYRHIFHADPDDHIKTFDDYDRYLPPKGVKAGHIFDQFMPAADARKKIDQIKGHLVWFPLDFLRDAEMAEKGLQVNQITESIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL52</accession>
    <name>A0A1B7YL52_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05041</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161262.1">
        <property type="nucleotide sequence ID" value="XM_018300016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL52"/>
    <dbReference type="GeneID" id="28864123"/>
    <dbReference type="KEGG" id="chig:CH63R_05041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05041"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="507" mass="55044" checksum="7F2976DB961A25AB" modified="2016-11-02" version="1">MPPLLPPVRRSRNGCIDCRKAKVKCDEIRPSCGTCARRRLVCQGYKTPAAHHSRHSLVDVAGGSDNPAAATTAVAATRSSGASPSRPPVGLSASEITAGERRPRMTLDTRTLSLLPPGAIPAADQPHIELYFNRHPFELLIGPEFVSEMNAFVVMMMQQDPVVIADAISAIGYSYEVGSSSGALLPVLDRRAKILANLRNMKPSSHYFEEALFLLLGLCAMELVTLAQPGHHATIPTVLSNVASLISHHVSTGGDVSSVASYVWLKNEPTKPDRLLGYTVTLMPLLEELCTLAEEVRGHILQPAALSVALLGGGGDTRTPSPEYTSSASSSSPPQLDVGVDSWLDVGYSDVALRADSLRMRLESWKPTISDGLSFRSARKFRAQAACYRAGALLYLHRLFHLPCSSPEADHEALSRAHDVMLYTSGPPPESKMLLWPVFMAACEMSDADDRAAVLDVFDAIGTHRKTVTVERTRAFVQERVWKARDEGGDWNWMVLAQAYPGECLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLT2</accession>
    <name>A0A1B7YLT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161520.1">
        <property type="nucleotide sequence ID" value="XM_018300274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLT2"/>
    <dbReference type="GeneID" id="28864381"/>
    <dbReference type="KEGG" id="chig:CH63R_05299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05299"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="68"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="176"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="457" mass="50898" checksum="11C548F05CDDAB28" modified="2016-11-02" version="1">MGELVKETSQLQLSSIPFGKPMLKEFLIDPAYHNMNHGSFGTIPRHIQTILRSYQDKAEARPDPFIRWEYHTYLKESRQAVADLINAPVDCTVFVPNATVGINTVLRNLIWAPDGLDEILYFSTVYGGCAKTIDYIVDTRLGLVSSRSIPLTYPLEDDEVVALFRDAVAQSHAEGKRPKICLFDVVSCLPGIRFPFEAITAACRELGILSLVDGAQGVGMVPLDIAALDPDFFISNCHKWTFTPRASAVFYVSERNHHLVPSTIPTSHGYVPRTGVQRHNPLPPSGEPPFVTRFGFVATFDNSPNLCVKHSIEWRKSIGGEDKIMEYLWALAKNGGKKAAAILGTFILDNKSETLTRCAMVNVALPIVMGADAETLSVGPDGTITVPEKEASVIVNWMLSALVNEYLTFVALFWHQGRWYSRISAQIYLDETDFEWVGNTIKELCQRVAKQEYKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM37</accession>
    <name>A0A1B7YM37_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161495.1">
        <property type="nucleotide sequence ID" value="XM_018300249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM37"/>
    <dbReference type="GeneID" id="28864356"/>
    <dbReference type="KEGG" id="chig:CH63R_05274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05274"/>
    <dbReference type="OrthoDB" id="10262596at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="entry name" value="Glycerate kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="entry name" value="Glycerate kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00045">
        <property type="entry name" value="glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="Glycerate kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="41893" checksum="826647E8593EC181" modified="2016-11-02" version="1">MGSLPASQGMKILVCPSGFKGSLQPDVAADCIEAGIKSVMPEASVRKVPLVDGGEGFTSALVSATGGTLHPVTVTGPVGIPIASYFGILGGSNPEMPKTAVIEMAAAAGLSLVPADLRNPGLTTTFGVGELLAAALGAGAKRIVVGCGDSGTCDGGAGMLQALGARLIDHDGHSLPIAAGGESLLGLANIDLSGADKRLKDVSIEVAVNWNNVLSGPEGVARVFGAQKGSSATQTERLSAAMEVLAVVAGRLLCDNMVGLSPGGGASGGLGTGLRLIGAKLRPRYEVVAEYVDFDGLFTDCDLVLTAEGGIDDQTPRGKIPAEIGMRAKKHGLPVIAIAGTIGPGARVNYDVGIDAYTCILQRPSTLAEAILEAEKLTRESAECVMRMIVVGRMLGSKKPFSPMAQPPASTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM74</accession>
    <name>A0A1B7YM74_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161672.1">
        <property type="nucleotide sequence ID" value="XM_018296856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM74"/>
    <dbReference type="GeneID" id="28860963"/>
    <dbReference type="KEGG" id="chig:CH63R_01881"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01881"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="353" mass="37400" checksum="BA2D7B62DB7B360F" modified="2016-11-02" version="1">MALSVPRCSKQWNVTGQEGLESLKFSERELPELGDSQVSDTRLTPFVKFRDVTIPRGKYPWDIKPNVVPGSDGAGTVLAVGKHVTRFKPGDKVITILSQVYLGGLVTDQIAKSGLGGGIDGTFRTVGAFNEQGLVAMPTALTFVEAASLSCAGVTAWNALFGLSGKKVSAGQWVLTQGTGGVSIFAVQFAKAVGARVIATTSSAAKAKLLEKLGADHIINYRETADWGLEAKRLTGGVGVDLVVEVAGPTTLSQSLASVRLDGTIVTTGSAGGEAKGQEMPTFLDSWLSLVTVRGVWVGSRLQMEDMSRAIEANLDTLRPVIDSKVFQLTELKEAYEYLESGNHQGKVGIEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM75</accession>
    <name>A0A1B7YM75_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpene synthase metal-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161673.1">
        <property type="nucleotide sequence ID" value="XM_018296857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM75"/>
    <dbReference type="GeneID" id="28860964"/>
    <dbReference type="KEGG" id="chig:CH63R_01882"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01882"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="260" mass="29218" checksum="301B625CDC9117BE" modified="2016-11-02" version="1">MEAAKLYRQETIEYVHRCLGLSGDARKYDTPANEIIAFFKIIGDAVCEAYDLAEIKTGLVEHRELLFREIEFFMETSEVEQQRRLSTELPTTEEYLATRMGTGAVNVCTILNEYVKIFHVWEHNVDTGRAAYGISLPVDILRDVHMKVIWDQTNILVCVLPKDQQSVESIVPLLYNNLGSLAAAVSMVIEIIEKSIKEFDSAAALLLNKFADDEALVSNLKIYIDACRLNCTGNLNWSLQTGRYGVSQQTITGGVTMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMN8</accession>
    <name>A0A1B7YMN8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161827.1">
        <property type="nucleotide sequence ID" value="XM_018297011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMN8"/>
    <dbReference type="GeneID" id="28861118"/>
    <dbReference type="KEGG" id="chig:CH63R_02036"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02036"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="23830" checksum="DBCD77C40D882363" modified="2016-11-02" version="1">MGTIQIGSAIVLTWASTPIKISCSVTSRLASLKRFTPALTRAFTHSLARDPGNNIGVLVPVVSQCLEKAALYRPQPKAVFGTRSAALPSDRRRLRQGAELRLCGCCYEPAPGGEVVWQLQDGSEQRQKLGLLAFLGRMGQRKASVVEDGEYENENELPRTRPRPIWISERIPQGAKYSLSYEMSRFKDKCPHQCRNHFSARSVTDTVCPSLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNW9</accession>
    <name>A0A1B7YNW9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf28 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162274.1">
        <property type="nucleotide sequence ID" value="XM_018297458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNW9"/>
    <dbReference type="GeneID" id="28861565"/>
    <dbReference type="KEGG" id="chig:CH63R_02483"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02483"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="107"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="30521" checksum="97F86FBBC752665E" modified="2016-11-02" version="1">MRPLAPVPVRSIASRIFAAPAPRVQPAFPFCHQCLRPLSTTPAAPSGHNKWSKIKHRKGAADAQKNSMRSQHSKMIALYSRPGVPKNVIDSAVARGQGRTASGASLEPLTLEAILPPGVALIIEAETESKARSLQDLKVLIKRHKGAANAAAFFFTRLGRVVFEAAGEGGGGPGVDDILDDAIEAGAEDLEADDDGNLVVWTQPNMTNAVASGVGPKFGLKLLSSDIIWSANDDTKVKLDKGLEATSLADLLAALQEFPEVQAVYGNPVKGDMSEEEWARIEENLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP29</accession>
    <name>A0A1B7YP29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_02430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162221.1">
        <property type="nucleotide sequence ID" value="XM_018297405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP29"/>
    <dbReference type="GeneID" id="28861512"/>
    <dbReference type="KEGG" id="chig:CH63R_02430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02430"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="212" mass="23696" checksum="DF5B05824A238AB6" modified="2016-11-02" version="1">MYHLAKGLYLLATSKEEYSVILLGLDNAGKTTFHEQVKALFLPGNPEPKLKTVPTVGQNVSTITLPDMYLKIWDVGGQHSLRRLWQSYYASAHAIVFIIDSTDIGDGNLDHDSSGRLDECRLVLEDVLQHSETEGVPVLVLANKQDREDCVEVVRIKEGLVKKVFEGEKASSIRDSRVLPVSALTGTGVKEAVEWVRSRVKWNKESRPPVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPB6</accession>
    <name>A0A1B7YPB6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sister chromatid cohesion and dna repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162245.1">
        <property type="nucleotide sequence ID" value="XM_018297429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861536"/>
    <dbReference type="KEGG" id="chig:CH63R_02454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02454"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1273"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1279"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1297"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1310"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1368"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1416"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1464"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1484"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1510" mass="167982" checksum="8D37C80DB5281B5A" modified="2016-11-02" version="1">MAPRRGRAEPQEEVEEEQGEELVSLQFDEELTWKPGKPIPTTELLNRLQTLSEELGGLDQDTVDVESLNDVAYALGQRNLLAHKDKGVRAYAAVCIADILRLCAPDAPFTADQTKMFFNLVVTHIFPSLNDQAHPYHSQHKYVLTALTDVKSILLINDVDGADDMLLKLFSVFFDGVSGGSNSSPEEGVSKEVRNTMTEMLIALVDEASGMNPKVIEVIMAQFLRAAPPGGFHSRTERGEQNGSQSTLLPKDEPAAYIMAKEICNVCTEKMVHYVSQYFSDVILDASRFAAKTVGNRHDEEEDEDAPRGPTDAELKELKKAHYLIRELWRAAPSVLQNVIPQVEAELSADNVDLRQLATETLGDMISGIGAAGPPPPPVLDPAQYPPLRLADEAPSQISDNVLTTPLSPQSFAQTHSSAYNHFLGRRNDKTATIRAAWTTAVGYILATSAGGIGLNREEQSELVKHLGEKLNDGDEKVRLAAVKVMELFSFRDFVTKLAAPGGVDKDGSVLSSLADRCRDKRTAVRVDAMTLLAKLWAVGSGELAAGQESVVVALAGIPSRIFNAFYANDSELNILLDRVLFECLVPLSYPPIKAPKNTRAAASQSSQTASVADQDRIRAERILLLTQSLDAAAKRAFFAMQGRQPQFAQVLEAFINQCESYNGGVMDDNRPRKTANLERTVQYITQFFPDPFKVKTDLQKFANLNDRRAYQLVRFSVSAGSDYKTVRQAIKELVKRINASQVATSLDTLLPLLYRSACLLFNRSHLATILDYSRNDKDGLGSVSHEILNEISQRNPELFKTHVGELCKGLIEQAPTETNENDSTVVDTLKACASYSKKYPEEIPQDRKFSQALVNYALYGRPVKSAKYAIKILLAKADDKGLVNATSLLEKVMEDWKYGSSHFLNRLQSVAQLELQAPKITLDSDDDILDMTVQQILLKVRTDATDKDPDWVEDADVDEELQAKCLSMHILVNRLRSMEDVEEAKEKAVPVFKLLKTLVAKRGELCKTKDTPNHHKSRLRLLAAQLLLKLCTVKHFDDFLTPADFNRLAFTAQDPHLSVRRGFIEKLQKYLVQGKLRARFYTIVFLTAFEPSADLKQRVETWIRSRVRALQTSEQHPMEAIMGRLISLLAHHPDFTKPENVDDASSDELSAYASDLADHGRYILYYLTNVATEDNLGLIYKYAERVKQTRDAIDPEASENLYIVSDLAQAVIRKWQERKNWSFQAYPGKVGLPIGLYTALPSHQVAQEIAEKQYLPSEIDGKLDGLFKSIDRKKKRKSVDERGDHQPAKKARQAPRVKEPKAPKEPKVKKQKVKKPAKVKTRRPESDIPPENRRRSGRATRVSQYTERDSSDDDREMWDGVSKWEYVDGEPEDESDDEDGSSVLSDAPDEENGEKGSKKSAAKANDSGDESPLSDVEDEAIAEPDAEPESEKEEEEAGEEVEEEEAEEATPPPKSNGRKGRSAAAAAKTKLPARPAAREKPAPRAATRSSARTTRGRAAKESMDIDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQG5</accession>
    <name>A0A1B7YQG5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162770.1">
        <property type="nucleotide sequence ID" value="XM_018297954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQG5"/>
    <dbReference type="GeneID" id="28862061"/>
    <dbReference type="KEGG" id="chig:CH63R_02979"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02979"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="828" mass="92036" checksum="BB596FF5EDF3666A" modified="2016-11-02" version="1">MLASRTVCAQCRPRLLPSAATLGTIRPSSTASFPAAAAAATATANPARPTAQPRHVRPYNIPPKRSADGDQSARQRALDLFEETISSEPRASPVTSQDVNQLYRLADELDTITQNKKGLPEAEVAVKTYELISTRILPALRASGSPLPTVVKTKATLAMHQIANVKFSNIDNADLPSTAGICKVYADLGNLRVVKRLELINSLLRAIVSSPSGSGTRCVEERLLDDLVECWKHFSGMRRADSGLASEAKFWLTTRPDMRGVEQPVRLFRALFPLFAINELRGSGAALVTTFVLLSESRHMLTRAREEAQPLLEALDPIVKRFDQEMLRQMFEGYPELWSHVQPRADWRVTRMAHEAWKEPGTPPVESSPSRARSPGLFSYAQWHKRFDVAFRSNDHAAAQQAWRDLVDPANDAHRAQRLRDSPELLDYILFLACSKWAVDAEGFSKMTANVLAYMREVESAPTIRTYTSMMKGWKQARRLDPIEKLWASITASGVRLDEHIWTTRIAALGHLSHEKAGLAALKEMETVWNTAVKKGTQNTAVEPGIASVNAAISGLLKQDRMEVIRAVLAWAIERGIEPNIFTYNMLLARMLKKGASDEADRILSSMRSAGLAPDAATFTIILEAALEDLPDQAPAEQRETIDKVFSEMAACGIEPNQEAFAKMLHVLVKAGDAAEHSVAAVLAQLRSTGMQPSTEICTILVEYYASRERPDLDSLRALVADRRSRTRALTDRVFWESVIKHYHRAGDLDSALEIVYDLDDWGIWPALPLLEPLLRELIRRQDWDGAKMLVDTVRKQARPQAAAAAGNKGGRYWNHGFWAAAKDYELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQQ3</accession>
    <name>A0A1B7YQQ3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_03097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162888.1">
        <property type="nucleotide sequence ID" value="XM_018298072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQQ3"/>
    <dbReference type="GeneID" id="28862179"/>
    <dbReference type="KEGG" id="chig:CH63R_03097"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03097"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR14371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="227" mass="24679" checksum="A5463AB5610D7EEC" modified="2016-11-02" version="1">MSAPGQTATPPPDAKISAADGRSYWQGIDADVNGMLGGFPYISKVDLQGSRNFLAKMGIGSKSGLRTVSRALEGGAGIGRITEGFLLDVAEQVDIVEPIAKFTAALQEKPGVGSVFNIGLEEWKPLEGTTYDLVWNQWCLGHLTDDQLVDYLRRCKAVVAPNDGVIVVKENLSTGGVDLFDDVDSSVTRVDEKFRALFEQAGLRLVKTELQRGFPKELFPVRMYALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQT8</accession>
    <name>A0A1B7YQT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162926.1">
        <property type="nucleotide sequence ID" value="XM_018298110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQT8"/>
    <dbReference type="ESTHER" id="colhi-a0a1b7yqt8">
        <property type="family name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="GeneID" id="28862217"/>
    <dbReference type="KEGG" id="chig:CH63R_03135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03135"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="311" mass="33610" checksum="DCEF2A16FF1ACC1A" modified="2016-11-02" version="1">MGYTIEDAFIPSSRDGCKIAISIYKPDGVKRPMPTVVMAHGIGAIKAAGLSPFASEFTSEGYAAVTFDYVGFGESEGTPRNVLDVRRQLQDFRDVVRWAREPEQGGWVDAARLVAWGSSFGGMHTTALVAEDHGLAAGIAQCPLVDGRAGAMKMPLGRSLRLAAAAVADIVGAYLLGAREPRYVDLVSDGSTTAVMASKEAAEGWARLTPRHGEEWPNIIAGRSLLNIMMSRPLLQVHKSTRPYLIVLPTWDHEASLDAAEECVRRAPLGECLRVEGGHFDLYEGGVAYEKNIAGQKLFLRRVLRQEAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRM5</accession>
    <name>A0A1B7YRM5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163121.1">
        <property type="nucleotide sequence ID" value="XM_018298305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRM5"/>
    <dbReference type="GeneID" id="28862412"/>
    <dbReference type="KEGG" id="chig:CH63R_03330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03330"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="148"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="401" mass="43965" checksum="1078ACE5C2593BE4" modified="2016-11-02" version="1">MTSPQTTLGPFGVLGLIFRLPVGTSRSHRVYPDPGPSLMHMCTALVLFLSILLRGLPLAIRRGISVRLWLLSAQYRLVLGYLEPREIQYLAAPARQVYPQWIAKQRAKVSRLGNVGALDRLGGDVEPLKEAGANIMWLGDRRKATKVVLFFHGGGYVAPVGLGHLTWCWNCYVDDGPGAKDEVAVAVLEYTLCPGARYPTQLRQAVAALNHLLRSGIAPADLVIGGDSAGGNLACQVLNHILHPHPEVETVRLSGPLAGVFMVSPLLTFRTDTASFRDNHRVDMLSAATVSKANRYIFPADFAKKKASNPHQPMPLDGDLEWFGEIQAVSKSIYITAGAQEVFRDDIRAFAEAVRRRNPDLDFKLDVAANEVHDSILLEGVFDVVGDATKRMRQWASKCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTT3</accession>
    <name>A0A1B7YTT3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease subunit rpt4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_00635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163972.1">
        <property type="nucleotide sequence ID" value="XM_018295610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTT3"/>
    <dbReference type="GeneID" id="28859717"/>
    <dbReference type="KEGG" id="chig:CH63R_00635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00635"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="245"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="468" mass="52967" checksum="5F200113B3837CE8" modified="2016-11-02" version="1">MGGRRLQWEVRRHLNLRKQRPDYTQATHHRPTDQLTLLTPNPNLPQHSQFIRFLHENRDAVNLRNPFSPLSPVTDLGMSSDDERQKALDSYRAKLLESREWEAKLKSLRLEIKDLQREFDRTEDNIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKIKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNDQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIALPNEVGRLEILKIHASGVVTEGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAINQDDFNKAVRKVAESKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTT5</accession>
    <name>A0A1B7YTT5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163950.1">
        <property type="nucleotide sequence ID" value="XM_018295588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTT5"/>
    <dbReference type="GeneID" id="28859695"/>
    <dbReference type="KEGG" id="chig:CH63R_00613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00613"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="38780" checksum="3CB2B7426DC87B0F" modified="2016-11-02" version="1">MSSASVKKVSFHVAASFTAKDHPYDPSTHIFHFNPYNRIQQTRNKRSRPDSGHDAFFVSRAGDSGSVALGVADGVGGWVDSGVDPADFSHGFCDYMASTAYGHGSTKSDPTTNGTGDKEPLRAQGLMQKGYQAICEDSTVVAGGSTACVAVASPDGNLDVANLGDSGFIQLRLNAVHTYSEPQTHAFNTPYQLSIVPPSVAARMAAFGGANLCDFPRDADVTQHNLRHGDIVVFATDGVWDNLFNQDILRIVSRVMTSTGAWLMTKNGVRVVDNLRPFTKPSEDAAERPPSKFLTLQSVLAAEITAATKSASLNRKVDGPFAKGVQKYFPQENWHGGKIDDICTLVLIASEDNKAEPKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU74</accession>
    <name>A0A1B7YU74_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoskeleton-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164001.1">
        <property type="nucleotide sequence ID" value="XM_018295639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU74"/>
    <dbReference type="GeneID" id="28859746"/>
    <dbReference type="KEGG" id="chig:CH63R_00664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00664"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="339" mass="38834" checksum="4D07EBDDAAA892C3" modified="2016-11-02" version="1">MTFMSFLRDERVILVGIGAATFGLVTMMTQMLTYIRDDNEVKVTPPKTQYITQETEDALGLDTLDKLLCHPNFSIRDVAIKILCDRAVNDPDTVRHLLYGITRPDYDTRMKNLRALATLTGQTNDFAEGLSKLHTWRAYTALVRSLELSLDDVEQAKLDDKYWDEYYLRDMAERFCLMFVLELITKYGADMLVKARFVEKWLAKQHWGDDEAERQENFTYYMEHKNNRIVDIVTRIAHTTQGAQAILACGLVSKTRPGINPDPNLSGFTVVLQSTLCNVDNVDGDEEGLHAVGQVPRAQEHSAEEQRLRRQHREAMVFNDGTRPIGREDIIERNQDSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUE1</accession>
    <name>A0A1B7YUE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cellular morphogenesis regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_00849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164186.1">
        <property type="nucleotide sequence ID" value="XM_018295824.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28859931"/>
    <dbReference type="KEGG" id="chig:CH63R_00849"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00849"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="394"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1376"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1882" mass="208345" checksum="BBCBEFBC14624904" modified="2016-11-02" version="1">MALEPGSGRRSVSPESSGRESPLPRQWRNQLGAEEAPIKDKHYRKYASGIERALSLFETALQEWADYISFLNRLLKALQARHPSTTTIPSKAVVAKRLSQCLNPSLPSGVHQKALEVYSYIFATIGTDGLSKDLPLYLPGLASTLSFASLSVRSPFLDLLEHHFLDLDPRSLRPAMKSVVLALLPGLEDETSEDFDRTLRLMDSFKAAIRPVNGQEQDGPHSSGDGFFWQCFFLASITGSSRRAGALAYLVRNLPKLGEPIVQGKSAKNGVQEDEQSAQLAKMVTSPEPGLLLRSFAAGLADEQLLIQRGFLDLLVTHLPLHSKVLQTNVKPGDLELLLRAAVGVVIRRDMSLNRRLWAWFLGPDPAPGESESGIESPSSTDHQHSYFASKTSYFEDHGLQPLTRALLSMINVDQGSSPGERARPYRICLSLMDRWEIGGLVVPEVFLPIVNSVRQYRDQAPSKADFNEVFRSASVFFDGVESGLIYGEIVSLLAQAIGPGTLSDKERLDKLDLVNFILANFNVREEEMVTIHAPLTALSILCMLEDTREKQQRQQAGFSRKGSRKAAEEALHISLTILDLIPDRAFPSSSANKPKRTMESGVLASLPAVELLKRIKAFYVDEQGNLDAVHVPLSPIEVGELLLQKSGQLVCEGLKNPESGSDLGAKGRILTTLLLKVPTTYQLDTTYLLSCLHERLGHSDGLSFVSYNSILYLSSHLYSAERIELVDLTELVTPLVRQAWEFLSASEPKHHVETVRSLWQLQTALSSQNRDIEAALASLIIEDDVQGSFASRPADAGRRFSVLWSHTLQDSSAERRGSRTPMVEKPPQIRMSGSENYEVMLTRPLFLMLDALLDERTQLFMTVKGWLNSLVGIDKLFLLFVRKFSSMEFLRSSRDIGSAAASANSTTFTVDDDLDLCLYYLRTLSNVLRWAPDVIWAVLGSTSLTVDNDHPEIAQMTGSEGDISMQEVFIHVCLRCIAGNNEPAEENIRIRATQLHRYALTVMHQILLNPYAEPLASLHLEDVLIERLLQSLSGPDPYVQVLLLDVVFDALKLRDIIISDVPASPSSEKRKMSLDPTKTLRVSTQLETKPTAPPPNLLKCLQAGLSSPSSRSVLDSWVSFLTECLPFYSDTIFQVLIPLVETLCRQVSNTFNDLQSIFRDNGSSRKDAWNAPESTLISLLNALEQVLARAHERLLAEEARTQVVKGPDQHPGFFGNMVSGVFNSDAPQTRSATANDRLTVHLAFADAVRICFTIWSWGQGSDANAQDMTSISSFNYTSLRMRNRARRLLEHLFAAETLECLETVIDIWRSSINITTPAPQSEVFNLLPALDGSRPKHTIPAIFNAIYSRTNPGALDASRKSTLTTSLQDIDLVTFLVEYARTLEDDAMDEIWLDCMAFLRDLLTNPFPHRQTLPSLLEFAAILGEKVDNTNFGEQRKMRRELGDLFLRLLTAIFTTKPMTYADAPSYEKSEKNRDGIRRATTISLVSVLDRAEDVVAILASIVPNLPKILVETDRVLSAAGTISTNVISPAFRAKAFPDTVSKNTLVLLQELSRLPNNQKTWKKDVGDAFNDARFFSSSIELVRSDWLPLLRQWTVSDKERMPELLSRMTPPTTAGIVFGVGATSARLEADRKTQLNLRRTATLVLASSEDAFVAELPTILDKVVELLGATATSSPSSTMRAEIYMVVRALVLKTSAVHLAMMWPVINAELHAAISSVVAPDHSTASDTYNNTSILQACKLLDLLICVAPDDFQLHEWLFVTDTVEAVYRSTSYQPVALVDELAEELGTMGVSSSLGSISAAHLATSSSHRRPLLGAGGINDEVGIDRKDELVGKILRPFFGQLSIFAFESTYAMAPLDREFCILGLLKDLFDERSVVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUZ9</accession>
    <name>A0A1B7YUZ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ester hydrolase c11orf54-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164225.1">
        <property type="nucleotide sequence ID" value="XM_018295863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUZ9"/>
    <dbReference type="GeneID" id="28859970"/>
    <dbReference type="KEGG" id="chig:CH63R_00888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00888"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="35060" checksum="CB07100752812AB8" modified="2016-11-02" version="1">MRVETFPLSPPSLEEIAAHLQAPLAANYTHASVGVVRCPDLRAAPFHLATEGLSGDEKIADVGGQPNLFPRPRLDTIWSLPEVARAIGMSPERGGLIGAGAGPFHVLGQNSELAPNLGWSGGLGENEIDNQSRVILIERGSDGGDGTTGKKNAVSVRAAPSTDCGLMANLFASRGEPGPVLRIAARGRKGPEKSFTECIRQGLRAAYGGERTVSLGGAFVVRAGRATYHVMPDFPPERDLPFRDRRAVEDWLTFHDFDAPVVGLSVLHSADPAGGMALRMEHTHAFSAAGEDAGGHYHFEAEGEGDVIEYEGYFNTAKAIYRVDRPAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVS6</accession>
    <name>A0A1B7YVS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lecithin:cholesterol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164495.1">
        <property type="nucleotide sequence ID" value="XM_018296133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVS6"/>
    <dbReference type="GeneID" id="28860240"/>
    <dbReference type="KEGG" id="chig:CH63R_01158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01158"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="659" mass="74006" checksum="C92A38D30247596A" modified="2016-11-02" version="1">MSSSTIRRRALPVDTQVENESPTPRDESPEKSEATAHVVRHVKPKTRKRRNGAIFLLGSLFGIIAAGFFAKSNDLIDFPELGELSMDSLFDVLPAGLVKDMRDLVVSNTSFLGLEGDLTPSWPELTRLLVKQGEREFVDSYDAFSVGLQARAEGLHAHHPMIMVPGVISTGLESWGTANVSRQYFRKRLWGSWSMMRALVLDKENWKRHIMLDQDTGLDPPHIKLRAAQGFDATDFFITGYWIWNKIFENLASIGYDPTNSFTAAYDWRLAYPNLETRDQYFSRLKSYIETAHEFSGKKAVLVSHSMGGQVLFYFFHWVASESGGKGGDDWVEQHVEAWINVSGCMLGAVKDLTAVLSGEMRDTAQLNAFAVYGLEKFLSKDERAQLFRAMPGISSMLPIGGDAVWGNSTWAPDDLPGQDFSYGSLLNFRSGMNWTTPDRNLTVESAMEYLFNTTEEWYSRNVKGAYSHGVAHTEADVEANEKDAQKWINPLETRLPLAPSLKIYCFYGVGKPTERGYYYRSPEMPALTNLNITIDTALTQGEVDHGVVMGEGDGTVNLLSTGYMCNRGWNYKRYNPAGVKVTVVEMEHEPERFNPRGGPKTADHVDILGRQHLNELILRIAAGKGNTISDYVVSNIMEYADKVKVYEDDERPIEEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>H1UV38</accession>
    <name>H1UV38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04359</name>
        <name evidence="8" type="ORF">CH63R_07590</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000177">
        <property type="protein sequence ID" value="CCF31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157343.1">
        <property type="nucleotide sequence ID" value="XM_018302565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UV38"/>
    <dbReference type="STRING" id="759273.H1UV38"/>
    <dbReference type="GeneID" id="28866672"/>
    <dbReference type="KEGG" id="chig:CH63R_07590"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07590"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_6_0_1"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="5">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="540"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="915"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1236" mass="139305" checksum="374E83F358933DD5" modified="2012-03-21" version="1">MAEYHGDPRGHSSNYQRDAAFSNIFGAAPPPGRSQTMTSSSMPPQMMPQQGRTQTMSSSTMSSMQRQPPPRVPPGQYMDREPSSPRGAPVQHNGYAAQQRSASGGYQVPNPQAHYLQQQQQQARRPYGGPAGPLPPRGDARGPPPSSQAQYGPPRTAAQRYYQAGGGAGPALNNDPYRSQSLASAPRPNMYQPPPSAYGSQPSHQAPANAFRQPPYNPSSSRTTAQGRVVPERHDDRAMSMTGYPPQDRDMHQQQNSHQTMSGRVIPNRRAPVELPATNGSFGGGYTPAPGSQTRTTSIASSNGDSHAQRTMSMASTVAPTITPSESDAATLAHRPSMSKSIDGERPPTAKIRPPLVYPALLSRVADCFRQKIITGDRTKNELTYKNAFSGAEAVDVLSYIIRTTDRNLALLLGRALDAQKFFHDVTYEHRLRDSTSEMYQFRETLMEEPEEKPPVNGVFVLLSECYSPTCTRDQLCYSIACPRRLEQVSRLNLKIQPGLKKESDNAANEDDVDQTDEQKLWINSVPREVADSVGDREKKRQEVISEICYTERDFVKDLEYLRDFWILPLRSKASPIPANKREKVVKSIFSNIVDHPSLHAVSSRFAKSLTERQQKNPVVGNIGDIFAEWVPQFEPFIWYGARQLEAKFEFENERSANPYFAKFVDEIERRKESRKLELNGYLTKPTTRLARYPLLLENVLKYTEDGNSDKEDIPKVLKLIRDLLTRVNAESGKAENRFNLRRLHEQLRFRPNERVDLRLTEEGRELVFKSQLKKTPQDASEITAFLFDHAVLLVRVKQAGKGEEIKAYRRPIPLELLAIREMEEVIPGSGAMKRSSSSLIPQLRTNTNDSKKGEGWPITFRHLGKAGYELTLYASNQAARKKWLEFIDSAQQRLRARADFFNTSVISAGFFVGTNQVNCVTPYDGGRKLLYGTDNGIYLSDRKSRDAVPKRVIETTSVTQLDVLEEYGLLLVLSNKALYSYPLGALDPNEPALSKRPKKIQSHCNFFKTGICLGRHLVCCVKSSALSTTIKVYEPNDAMSKGKKQKGFGKMFAGQDELKPFKEFYIPTESSSVHFLKSKLCVACARGFEVVSLETLETQSLLDQADTSLDFVARKENVKPIHIERLNGEFLLNYSEFSFFVNRNGWRARPEWRIDWEGTPQSFALSYPWILAFEQNFIELRNIENGAVHIVPHKNIRMLHSSTHEIIFAYEDEKGEDVVEAIDFWKTNNRRSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVV0</accession>
    <name>H1UVV0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_04556</name>
        <name evidence="5" type="ORF">CH63R_09683</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000321">
        <property type="protein sequence ID" value="CCF32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156680.1">
        <property type="nucleotide sequence ID" value="XM_018304657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVV0"/>
    <dbReference type="STRING" id="759273.H1UVV0"/>
    <dbReference type="GeneID" id="28868764"/>
    <dbReference type="KEGG" id="chig:CH63R_09683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09683"/>
    <dbReference type="eggNOG" id="ENOG502TE0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000537_4_1_1"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="3">
        <location>
            <begin position="328"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF32101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="53262" checksum="B7B847FE7CFCF6ED" modified="2012-03-21" version="1">MSSALHLGCTGPQRKPLIVMMSIPTYGHTLPLLKICSHLVARGYSVFFIGGTEHQAQIRRAGAEFIEHPPWGITDEFKAERDKIVNVFRRNTFEAEHVYVGSMPQRHRVLRSTLEHVRRKHPEEEVLIMHECISAFATLPFFYGAPLPAGYSRLPKVINIPIYPMFVWSIDTPPFGPGSPPTTTWLGRLANLLLYYVIVSLPMYRQILGRVNQEMKVLGATRQVTGWLPDVVTTTADVVLMICSPSMEYPRSDLDPKIRFIGCLPNNVSTTSFRPTFQPPAWWSTIQENAKLPSQTRKRLVMVTQGTLSVDYNDLLIPLMQALAGRRDVLVVALLGGRDKELPRDFPVPSNAYVAQYFPYEVILPLSDISVQNGGYGGWTQAVMYGVPTVLAGATEEKRENVMRGQWTGTSVGIKKRRPSVQELREAVDTILESYDEYKSTVLKLKAENERLDAMTQIERATEGFPLDTVRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWH6</accession>
    <name>H1UWH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00784</name>
        <name evidence="3" type="ORF">CH63R_11998</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000391">
        <property type="protein sequence ID" value="CCF32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153813.1">
        <property type="nucleotide sequence ID" value="XM_018306972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWH6"/>
    <dbReference type="STRING" id="759273.H1UWH6"/>
    <dbReference type="GeneID" id="28871079"/>
    <dbReference type="KEGG" id="chig:CH63R_11998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11998"/>
    <dbReference type="eggNOG" id="ENOG502SC13">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_6_1_1"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="245" mass="26682" checksum="8E37FDCCF85F3D94" modified="2012-03-21" version="1">MTSVTLRPATRADVPALASVADAAFRTDAHTQLKAALRGVGNFAEGMEQALLAWVDHPKVDVVVAEDPASGQPVGWAGWVRRGFAGDIDLPLDDGDDNLSAEPTVATHLTGEKKGKRTVKDLEDLTNASMGYWVRRFMPEGSRCRFLCSCVVHPAFQARGFGSQLMRWGTDKADAEPGVYCWVQSSMGGRASFERQGFREVGRLEANLDDFAEGTTPGDGNGHITGSKDSWGNYVWVYMRRDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX01</accession>
    <name>H1UX01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fatty acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_04885</name>
        <name evidence="7" type="ORF">CH63R_04639</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000445">
        <property type="protein sequence ID" value="CCF32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160860.1">
        <property type="nucleotide sequence ID" value="XM_018299614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX01"/>
    <dbReference type="STRING" id="759273.H1UX01"/>
    <dbReference type="GeneID" id="28863721"/>
    <dbReference type="KEGG" id="chig:CH63R_04639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04639"/>
    <dbReference type="eggNOG" id="KOG0873">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_5_0_1"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="148"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="307" mass="36277" checksum="8A09E127EB4597BA" modified="2012-03-21" version="1">MAAFVNSTVINTAFNHTQPYFSVLEEVSKYNVQLNYFERLWAAWYLWMQNDILATGIMSFVMHETVYFGRSLPFIICDLIPWFHKYKIQPQKMPTLKEQWDCAMVVLISHFTVELPQIWLFHPVATWCGMEYGVPFPPLWKMAMQISIFFVMEDTWHYWFHRALHYGPLYKAIHKLHHYYSAPFGLAAEYASPIEVMLLGIGIVGSPIFWVTLTGDLHLLTMYSWIVLRLFQAIDAHSGYDFPWSLRHFLPFWAGADHHDLHHEKFIGNYASSFRWWDYCLDTEAGLEAHKKRREKKLKAIKAQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX88</accession>
    <name>H1UX88_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
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    </evidence>
    <sequence length="318" mass="34661" checksum="E426B32B26EA6DCB" modified="2012-03-21" version="1">MPPPPDLSRYILPDTESREIFTTKILPADLPSSLTPHPTRPRPLAVLIVGQTGAGKTRTAPAVLGAMARCQPPVHLIADVYKAHHPSYLALLDSDNPAHASPATGPDARKWLAMAAAEAIARKLDVLLESACRHPDDFRELAGMFGEAGYRLEVVIMAVPAALSRLGILHRFYERLPEAGSGGLPIRLTPVKVHDDSFGGLMSVAEWIDGVNYVDRILVVRRGNMVAFADERGRDGKLQGTVAEAVRIERDRPLTKEERESALGDLEKLAARDAKLAEQVMSLLEPLLVEEDQTYPVLRPLSFPPHGPRDALLTLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYL4</accession>
    <name>H1UYL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_05326</name>
        <name evidence="14" type="ORF">CH63R_06411</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000628">
        <property type="protein sequence ID" value="CCF33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159236.1">
        <property type="nucleotide sequence ID" value="XM_018301386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYL4"/>
    <dbReference type="GeneID" id="28865493"/>
    <dbReference type="KEGG" id="chig:CH63R_06411"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06411"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="202"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="300" mass="32667" checksum="ED5E2A0F87C7D08E" modified="2012-03-21" version="1">MSTEKPLPFVYQFAAGAIAGVSEILVMYPLDVVKTRVQLQTGKGVGSDHYNGMVDCFRKIVRNEGFATLYRGITAPILMEAPKRATKFAANDEWGKIYRNLFGVAKMNQSLSILTGASAGATEAFVVVPFELVKIRLQDKASAGKYNGMLDVVRKTVQNEGILAMYNGLESTMWRHVLWNAGYFGCIFQVRELLPKAENKTAQVTNDLISGAVGGTIGTVINTPMDVVKSRIQNSPKVPGSTPKYNWAWPAVATVAKEEGFGALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRTLKTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYS3</accession>
    <name>H1UYS3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05376</name>
        <name evidence="5" type="ORF">CH63R_01424</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000648">
        <property type="protein sequence ID" value="CCF33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164761.1">
        <property type="nucleotide sequence ID" value="XM_018296399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYS3"/>
    <dbReference type="STRING" id="759273.H1UYS3"/>
    <dbReference type="GeneID" id="28860506"/>
    <dbReference type="KEGG" id="chig:CH63R_01424"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01424"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_4_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="138" mass="13737" checksum="4CECE448F33BB407" modified="2012-03-21" version="1">MSSAKGLALVTGANGFIGSRTVEAFLLAGYSVRAAVRSPNSASGLLGALPSYAASGQLSTAIVPDITAPGAFDEAVKGVAAVAHLASPVDFSNTNAEEVLGTALKGTLGILDSAVKEPGLKSFVFMSSIVAKAISKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0P1</accession>
    <name>H1V0P1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha beta hydrolase fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05917</name>
        <name evidence="3" type="ORF">CH63R_09162</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000899">
        <property type="protein sequence ID" value="CCF33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156159.1">
        <property type="nucleotide sequence ID" value="XM_018304136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0P1"/>
    <dbReference type="STRING" id="759273.H1V0P1"/>
    <dbReference type="GeneID" id="28868243"/>
    <dbReference type="KEGG" id="chig:CH63R_09162"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09162"/>
    <dbReference type="eggNOG" id="ENOG502QW6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027502_2_0_1"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="580" mass="66575" checksum="F6D0208A6080FAED" modified="2012-03-21" version="1">MIVQKTWPQYIAVRVLIVMMRDLGLLGFTYFYAIFALGGVKAIAHPVSIFIEVIAAIEVLFYLFFFLPYRWYLQTYKPYRPPPMSRSQRARLFYKALSLVPDGEDFVRKWMLNAHMEDIRRENLKDWLLWALFEHDNTTNRPTKEINAELDQYIDDAEETFGIKLRSGRGKAEALRLSFDPVIIQHRSLFYYMVIGIFDNLMALYLLTQGYRHYKQPFSTFFKVFPVRLVNLLPFTHSAADGMSYWYRPHKSTTKRPIVFIHGLGVGLIPYMFWLHTIPKDVGILAVEMLPISSRVTTYPLPPTPELCEMIVKCVAQQRASQPAPGSGERGTWDDFVLIGNSYGTLLMGQLLQRADFAPRVAATILIDPVSLLLHLPDVAFNFTRREPTPSIRGRTGHGNEWEIWWASATDAGTAYTLARRLCWRESLMWREMLTPSLRNIEAGYYASGSPEETAVFGNGVQVGMRSTVILGGEDCVTAPKSVASYVYSGDVRWSPDDIEIWKRYEWTGKQELELMFLDGKDHGQGIMVPFPHKPIQNVIETYCRRDDGFEPFGDKFIGGPESIYGMPQQTQEVVELKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0T6</accession>
    <name>H1V0T6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01037</name>
        <name evidence="4" type="ORF">CH63R_01338</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF33837.1"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
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        <property type="protein sequence ID" value="CCF34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="166" mass="17360" checksum="2FFEA101BFA0C22E" modified="2012-03-21" version="1">MSSTPSQPPPAPAVAAESDPATFAHIENYISTRCNASPIYAFLFHPGLRLTHASKGLIIARLPVAANHLNTAGSIHGSVSATIVDWAGGLAIASWDLRDATGVSVDINISYLSGAKVGDEIEIEGRVEKVGGSLAFTHVNIYKVAADGTRGATVANGRHTKFVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2P9</accession>
    <name>H1V2P9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 78A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_06487</name>
        <name evidence="8" type="ORF">CH63R_06045</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001167">
        <property type="protein sequence ID" value="CCF34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158870.1">
        <property type="nucleotide sequence ID" value="XM_018301020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2P9"/>
    <dbReference type="STRING" id="759273.H1V2P9"/>
    <dbReference type="GeneID" id="28865127"/>
    <dbReference type="KEGG" id="chig:CH63R_06045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06045"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="538" mass="61014" checksum="C114326E0E051569" modified="2012-03-21" version="1">MNKVSFGPVMAATTTASFFAARALELSFLRTISIAWAIVIPLYVVVWQCYVFPFYVSEMRHIPTVAGFPLWGQFFDIISHEVGEPQRKWHEQYGPIIRYFFPFGAERLSIAEDEALKQMTVRNPYNYPKPVRAKLWMVRILGEGVLLAEGHEHVHQRKALAPGFSIQSIRSLTPIFWEKSLLLASCWRKEMRADGVSTKSFEALDWLNRTTLDIIGKAGFGYDVNSLENSDAPLREAYRLCFSFDIVSRILIGLQAFSPVFNHLPSKVNRDIMQSRSIIIGKATDIIEEKQKEAANNAGGKDILALIAHDNKKLKEAGEAGLSFETMRDQVMTFLGAGHDTTATGVAWTLHLLSKHPIVQSRLREEIKDHMPFLLDGNTRFDPDHVAVADADKLPYLDNVCREALRLIPPIPMTVRQSVDDDVLGGYKVPAGTVVYVLANAINRLPMYWGDRADQFDPDRWDDLPATVTPNAFMTFLQGPRGCIGRKFAETEMKILLCCLLSMYEFQRDFDTPDPEDWKMWRLVLRPRDGVTLRVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4G1</accession>
    <name>H1V4G1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_06964</name>
        <name evidence="9" type="ORF">CH63R_04408</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001405">
        <property type="protein sequence ID" value="CCF35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160629.1">
        <property type="nucleotide sequence ID" value="XM_018299383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4G1"/>
    <dbReference type="GeneID" id="28863490"/>
    <dbReference type="KEGG" id="chig:CH63R_04408"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04408"/>
    <dbReference type="eggNOG" id="ENOG502SDGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182424_0_0_1"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="47B78E6EE8EF0AFF" modified="2012-03-21" version="1">MAQTPQQRRANAKFAKDNESRMGKSEDQIKKRTKEAPKSPISPIWLGLLAFVVFGGIVFEVLSRMFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4I6</accession>
    <name>H1V4I6_COLHI</name>
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        <submittedName>
            <fullName evidence="9">Nadh-dependent flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_06986</name>
        <name evidence="9" type="ORF">CH63R_10377</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CACQ02001416">
        <property type="protein sequence ID" value="CCF35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154775.1">
        <property type="nucleotide sequence ID" value="XM_018305351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4I6"/>
    <dbReference type="STRING" id="759273.H1V4I6"/>
    <dbReference type="GeneID" id="28869458"/>
    <dbReference type="KEGG" id="chig:CH63R_10377"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10377"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="421" mass="45261" checksum="6BB439E032BB784C" modified="2012-03-21" version="1">MGSQINGTTASPEFAPIPSPAAKNAPYFTPEQDPVSGTALGTTTGAPTPKLFTPLTVRGLTFQNRLFLAPLCQYSAAADGRATDWHLTHLGGILQRGPGLSIMESTAVQREGRITPQDLGLWDDAQVGPLRRIVDFAHTQGQKIGIQLSHAGRKASTVAPFLHMNATSNAAVGGWPDEVYAPSALRFNDAYPQPRAMTLEQIGVFKTAFVDAASRAVGAGFDVVEIHAAHGYLLHQFLSPISNQRTDRYGGSWENRTRLVLEVVDLVRATIPEDMPLFVRISATDWFDDMKEEFPESWTVADSCRLAPILADRGVDFLDVSSGGIHPLQSTSIKGGPGYQAGFAKEIKRSVGDKMIVSAVGGISTGTMAEGFLQAGLDVIMCGRWFQKNPGLVYAFADELGTNVKMANQIGWGFGGRKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1V538</accession>
    <name>H1V538_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07148</name>
        <name evidence="4" type="ORF">CH63R_12523</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
        </source>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Montmayeur A."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
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                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCF35791.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="406" mass="43749" checksum="E4C4227BCC56CE4C" modified="2012-03-21" version="1">MRPSAHPLPPSSSLPPLRTLEQLSEADITSALQSLSAIYCSLPVSVAFQLTPESRRLAHHNKPLVDSGYVSETDDDHEEIDGVDHHIAALKVDAFERSFAERWLTGFIARAESLPCFESEEACQQALDQASCVLAAFFAVPETGADQDDKDQDYAREFAFELMVPDADTAKASVPITVRLNDRLAGTNSADPDDVGLQSWGASILMSEIMCASPARFGLSQPALGLSPRIVELGAGTGLVSLMLGNMLPHLGAPLPTIVATDYHPSVLNNLRSNIALNFPVPDTNHVQTAALDWSAPVLQAPLDIPADILVATDVIYAPEHAIWLRNCASCLLAPNGVFWLLVTVRQNGRFNGVSDSVEAAFTAVDGPKGKDGKRLVIVHSEELQKRTGVGRGDESGYKLLDIRWA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V722</accession>
    <name>H1V722_COLHI</name>
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        <submittedName>
            <fullName evidence="2">NADH2 dehydrogenase subunit 14K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07688</name>
        <name evidence="3" type="ORF">CH63R_06641</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001798">
        <property type="protein sequence ID" value="CCF36024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018301616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V722"/>
    <dbReference type="STRING" id="759273.H1V722"/>
    <dbReference type="GeneID" id="28865723"/>
    <dbReference type="KEGG" id="chig:CH63R_06641"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06641"/>
    <dbReference type="eggNOG" id="ENOG502SC0I">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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    <name>H1V895_COLHI</name>
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    </protein>
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        <name evidence="2" type="ORF">CH063_08019</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001983">
        <property type="protein sequence ID" value="CCF36447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018301494.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V895"/>
    <dbReference type="GeneID" id="28865601"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06519"/>
    <dbReference type="eggNOG" id="ENOG502RPCA">
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                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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                <person name="Hansen M."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Law A.D."/>
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                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Schardl C.L."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002356">
        <property type="protein sequence ID" value="CCF37199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159414.1">
        <property type="nucleotide sequence ID" value="XM_018301564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAE6"/>
    <dbReference type="STRING" id="759273.H1VAE6"/>
    <dbReference type="GeneID" id="28865671"/>
    <dbReference type="KEGG" id="chig:CH63R_06589"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06589"/>
    <dbReference type="eggNOG" id="KOG1236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_6_0_1"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="301"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF37199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="698" mass="78838" checksum="998EDE5B8A1A59E0" modified="2012-03-21" version="1">MRLAFALGRFCPRPGFRAPANGTQFYSTFRSAFRSRTTQPGRLPWRPNRYTKHNLRAGGAGAAALGTAAFFELSEKDNEGTDQTGEKRMLEVSRAEIKKKVADDDSGILRVWHTLMIAVDVYLWEPLCTGLRFLHLVVIFVPVIVTVPALWLGKRQPDRDNERSGTLWWYGFLVQSMEWAGPAFIKLGQWAASRSDIFPNEMCEIMSKLHSNAPAHSMRETKRIVSAAFDGRHFDDIFDEFDETPLGVGAIAQVYRAKLKPNLAAPSDNDIAAEGPKPLRQKVAKNVEAALKSTPRRVPSTYVAVKVLHPRVERTVRRDLRIMHFFASGLNLIPTIEWLSLPDEVAQFGEMMKLQLDLRIEAANLAKFRKNFRDRTTAWFPYPYTEFTTRSVLVEEFAQGIPLADFLENGGGVFQQDIASEGLDAFLRMLLIDNFVHADLHPGNIMVRFYQSHEPEIKFRRKGNHGRGEHPGDQGGDDDVTEQVLARLRPYRQRKDPAAWAAELRRIDNEGFRPQLIFIDTGLVTELNETNRTNFLDLFRAVAEFDGYKAGQLMCERCRQPDAVLDKDVFALKMQHLVLGVKSRTLALGNIRIGDILQEVLGMVRGHHVRLEGDFVNVVISILLLEGIGRSLNPDMDLLSSSLPILRQLSAQSGAQMAKHGDFSMLVVWAGLETRRFLQASIEDVERCVKYDLLAPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBN3</accession>
    <name>H1VBN3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_01743</name>
        <name evidence="3" type="ORF">CH63R_08307</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002557">
        <property type="protein sequence ID" value="CCF37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158059.1">
        <property type="nucleotide sequence ID" value="XM_018303281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBN3"/>
    <dbReference type="STRING" id="759273.H1VBN3"/>
    <dbReference type="GeneID" id="28867388"/>
    <dbReference type="KEGG" id="chig:CH63R_08307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08307"/>
    <dbReference type="eggNOG" id="ENOG502S1E7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043196_0_1_1"/>
    <dbReference type="OrthoDB" id="4841154at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="408" mass="45455" checksum="3D0112C34FF15F0C" modified="2012-03-21" version="1">MKDLDDAAYNGLMLSEISRLRAQINESAARQLASSLNGGKPCVLEYPSKIVGQGALTGCANYHVRIRFEDGSPSWLMRVPRVTGFAVGLPASLAEYLIRSEYATLKFLETTAVPAPRVFLFGIPSQGTDHGVGVCFLLMEELPGTPWNGQGNASKVWKGLAAIFAELEKHEFQQAGSLLVLSPEDRPSISATASDRFVCLNPWGPFDTSEEYYSAWAEQYLTLIADGQLYPQFPVEAYLVYQFLKENAAQLSEPERVFFLKHVDDKGDHLLVDDDLNITGIIDWQMARIVPRREAFALSLVSADMGALCNGQVSLSAKDAALSLALRDKSAHLARYTGDEIVRRFFWGLGLEAEWTYALPLAKAILVVFGVEEDWEEWRQGAFKRYEGDERLRALVRQVRHAHNSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBN8</accession>
    <name>H1VBN8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMC1 protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_08922</name>
        <name evidence="2" type="ORF">CH63R_14122</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002559">
        <property type="protein sequence ID" value="CCF37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151414.1">
        <property type="nucleotide sequence ID" value="XM_018309096.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VBN8"/>
    <dbReference type="STRING" id="759273.H1VBN8"/>
    <dbReference type="GeneID" id="28873203"/>
    <dbReference type="KEGG" id="chig:CH63R_14122"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14122"/>
    <dbReference type="eggNOG" id="ENOG502SD6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128881_0_0_1"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="111" mass="12714" checksum="7DEC63C3D5D10483" modified="2012-03-21" version="1">MTAAPHLRSIYRSLLRELPPRPVLARKRPPIHNRLRASFAPTKDNSLEADTAAVAAAEAEQLAAYLRAQRTYVTLLERYNPGMDMDEEERVRLSARRVGMDLPKEFKDRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCP0</accession>
    <name>H1VCP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_09200</name>
        <name evidence="6" type="ORF">CH63R_12892</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002745">
        <property type="protein sequence ID" value="CCF37993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152283.1">
        <property type="nucleotide sequence ID" value="XM_018307866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCP0"/>
    <dbReference type="STRING" id="759273.H1VCP0"/>
    <dbReference type="GeneID" id="28871973"/>
    <dbReference type="KEGG" id="chig:CH63R_12892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12892"/>
    <dbReference type="eggNOG" id="ENOG502QQ5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_0_2_1"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="98"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="253"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF37993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="41660" checksum="6DBDCC7273437BBD" modified="2012-03-21" version="1">MRSFSLLLSIIVGITSIVLFREQIFNLVVATTNDFFNFAGAIQNDIVSEAETKQQQQQYQRHHQQNQPDDHLYATDMSVPRAIHKVFLAVEQAEGAGARVRRSIGTPQLRNLSPFLMLDHFSISPGSGFPDHPHRGQETITYLLHGGVDHEDFAGNKGTIEAGDLQFMTAGRGIMHAEMPKQNPDGSANVGLQLWVDLPKHLKACEPRYRDLRAKEIPTVDIDGGKVHVKVISGQSHGVDSVRDLAYTPVWILDIQVKPGGKIAQPVPQGWNAFAYTLEGQAIVGTGSQQRVVDEFHNVVFEDEGDVVNIEVDAGADKDARLVLIAGTPLDQEVVQYGPFVLSSKAEVYQALMDFQTHSNGFERAEGWQSEIGKSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDM1</accession>
    <name>H1VDM1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09435</name>
        <name evidence="4" type="ORF">CH63R_10021</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <strain evidence="9">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="22"/>
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        <source>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="EMBL" id="CCF39270.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="568" mass="64000" checksum="75C7C5E872088A5E" modified="2012-03-21" version="1">MGAQQSSGRGQGEDPSQPVKTCYYELLGVQRDATDDEYILSSFRQALTHALFLTIFHVYRIKKSYRRRALELHPDRNLNDVQNATRRFAEIQAAYEVLSDPQERSWYDSHREAILRGADPDSDDRNPEYNDVKLTSTDDIFSLIRRFNSTVPFTDEPSGFFGIVKATFDHLADEEVAAGEYMPGDAPDYPSFGFSTDSYEAVAKPFYGAWASFSTRKPFAWKDKYRLSDAPDRRVRRLMEKENKKIRDEAIRDFNDAVRFLVTFVRKRDPRYLPNTQTAAERQESLRNAAAAQAARSRAANKERLSAAFVPDWAQTRDEADAGAHFPESEEEDSEVEEIECVVCSKTFKSEKSFEAHERSKKHVKAVQQLRRQMREEDLDLSLHETPAATDRGTSVEDALEGAGEQPNIKPVKGNDEDPVESELRTEEAELSDTTSEPLGGDEYASRADVEKRLFADQNPLTGTGRYDASKPNPAEVSASLESLSLGDDDGEQQDDSRIPSKKVGKAKAKREKRAARQMAEATQAGKHTCGVCENSFTSKTKLFAHIRDLDHAAPVAKPTADDKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGJ6</accession>
    <name>H1VGJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02113</name>
        <name evidence="3" type="ORF">CH63R_03321</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003445">
        <property type="protein sequence ID" value="CCF39349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163112.1">
        <property type="nucleotide sequence ID" value="XM_018298296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGJ6"/>
    <dbReference type="GeneID" id="28862403"/>
    <dbReference type="KEGG" id="chig:CH63R_03321"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03321"/>
    <dbReference type="eggNOG" id="ENOG502R0P1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104266_0_0_1"/>
    <dbReference type="OrthoDB" id="4589291at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="228" mass="26309" checksum="9C73BAB849B9A5B1" modified="2012-03-21" version="1">MKIVTAASPVVPDAAPRQTAPPQYDSVSHAHRVQNYDLPAWQDTSYTACFLFDSKSPSDGAADPESEWEARLRVKSRDLPRLMREGFHWTPANFDPGATYIQKDLSGEKKTIKRRWTQSRNFFLSDLSDNPYWAATLVIYARSTRVLSRFKVTDVTPDTMSWAAAWKKDEHWGNVHWIYEWDCRRPQESYNAVYGEMPLDGWWPWPKRAVNDIPPECGSVVGRQNNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIS7</accession>
    <name>H1VIS7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siroheme synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10783</name>
        <name evidence="3" type="ORF">CH63R_05260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11506.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="372" mass="41595" checksum="FA7B4C6987F2A42E" modified="2012-03-21" version="1">MSVESRRPSRLGIRSLASKSTHFASRLKRSCRAQSAANGIPSIPVIAMSKLLLLSDSDLSENLPVLPTAGGPCSTSSKHLWSGTHLHLDSSGRTNAEMDNQLETAFLGRLPDEIREMIYQELWRAAGLGQHIIRTQAGYAHSRCLFHRVGSRAGGGVDGEDPWESNWMAPDARGPVPLWFQREMSTWCDHWKCEEAREEREIWRDITSRSRTCHCARADTWTAFLPMMLTCKRMYFECASSIYNSVAFTITDINLARNVFCVRHRGPIGGGGGHPLRRINLSFRRQADEGSNFEQWVESWSAVLRHLDTPGLVAVNLWLDSDVYYERHWLSVTGNTGIGTGLWGMHGGEATAEEWRGVSMRDGYSLEGSLGA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLH3</accession>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Sykes S."/>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004473">
        <property type="protein sequence ID" value="CCF41076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158309.1">
        <property type="nucleotide sequence ID" value="XM_018300459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLH3"/>
    <dbReference type="GeneID" id="28864566"/>
    <dbReference type="KEGG" id="chig:CH63R_05484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05484"/>
    <dbReference type="eggNOG" id="ENOG502QZ63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049199_0_0_1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="35628" checksum="4D52FD76251BCCEA" modified="2012-03-21" version="1">MSRATWQEDFEKNGFAVIPSVITRDKAAHYQNQAFAWLQSFDNPALDLANPATWTPGNLPFISGINTFNHYGVVHEKFMWDIRQEQGVIDVFAKVWGTDELIVSFDALNITLPRRPDHAPRQKWPHVDQSPYRKGLECVQGIVNLSKAGPEDGGLTVYPGTHKVTESFFRDRTDRAQWTRKDFFNYTPEQIAWFEEQGYREHKVVAEPGDLIIWDSRLIHYGAEPTPESDTIRTITYVSYAPASFATTEALGAKKQAFEKWQATTHWPHDNIVPRTNQPTLPDGSVDARRSEPREKPELTDKLLKLAGVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLH8</accession>
    <name>H1VLH8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_11467</name>
        <name evidence="7" type="ORF">CH63R_07484</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004478">
        <property type="protein sequence ID" value="CCF41081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157237.1">
        <property type="nucleotide sequence ID" value="XM_018302459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLH8"/>
    <dbReference type="STRING" id="759273.H1VLH8"/>
    <dbReference type="GeneID" id="28866566"/>
    <dbReference type="KEGG" id="chig:CH63R_07484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07484"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017278_0_0_1"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="338"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF41081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="519" mass="54719" checksum="B1EBF26FE4806D35" modified="2012-03-21" version="1">MAAPAFLQQSQPFRSSNTQAPFLSSVNPFDRDATKPVGTPFANSVPVASSVLIRRLPLNTSEESLRLMVVWSKELVDVEVLPVDQSEDIGFRSAVLKFRSTNGAIEAKNMLDGKSNISNDASMIVEVLGGSPTAPRRYAEPAGNGSSSTTSSAASSAPSSRQPSRFNGAFQSLEKISPPMNGIYGSSELPNPDSSAHYQNLFSPQSPIGNHLTERTRISGKSLINDDAADDDETGELLKDPVAYAENGATAQRRATAPQLPISRLASLSLNTSATPSPSSLPQYGQQGMSAISAHPVMSPTAMGGGPHSVPFPMGGNHPYGRHNFPPVNPADQNPPCNTLYVGNLPIDTSEEELKAMFSKQRGYKRLCFRTKQNGPMCFVEFEDVSFATKALHELYGHPLHNSVKGGIRLSFSKNPLGVRSGQTPGPATSPMSGMMAGSANGFKTTNGPPPGLAAPPGLGTGRFNGNPGAQSYTVAGFPASGNNNVWNGYNSNAMTAGGPGSLMNGNNSNYLPPHMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLY4</accession>
    <name>H1VLY4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11578</name>
        <name evidence="3" type="ORF">CH63R_04208</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR11912.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="7630" checksum="D8DA08222B672C72" modified="2012-03-21" version="1">MPARQDAYSVSIPVSPPPPSDISTYMRSMHQHTKRQMEAANRSSSRRSGGRTSYPHNGHHSSSSPDYSS</sequence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004791">
        <property type="protein sequence ID" value="CCF41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR15799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018295954.1"/>
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    <dbReference type="GeneID" id="28860061"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00979"/>
    <dbReference type="eggNOG" id="ENOG502R6UB">
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">IMI 349063</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11750"/>
    <dbReference type="eggNOG" id="KOG0682">
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AMMONIUM_TRANSP"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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            <begin position="42"/>
            <end position="63"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="44"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF42201.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQ06</accession>
    <name>H1VQ06_COLHI</name>
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        <submittedName>
            <fullName evidence="3">TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ORF">CH63R_01076</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005293">
        <property type="protein sequence ID" value="CCF42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164413.1">
        <property type="nucleotide sequence ID" value="XM_018296051.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VQ06"/>
    <dbReference type="STRING" id="759273.H1VQ06"/>
    <dbReference type="GeneID" id="28860158"/>
    <dbReference type="KEGG" id="chig:CH63R_01076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01076"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_3_0_1"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="PHI-base" id="PHI:8878"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="163"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="471" mass="51688" checksum="78B7B1A6BDC4E946" modified="2012-03-21" version="1">MPQSPTGDPFAAPAHAFVQSQAKTTELLPPPSPRTHRLRKLQSAHNLGSKAALQLQPQHQPSLIAQQRLTQRNISPTRRDPSASSTVTRHTRGRSNSDAPAPVAHHMTALASSKRSMMGINPKYATMSLQQLIKEGPPDGDTVEALGMARRKVLSEGIKSDSDGMSTLRIYVWLILLDTPVLPTDDYLGLIHRGASPAYSKIRNDTFRTLTTDPLFRRRVSEASLIRLLNAVAWRLHDLREEQRRERPSTGRSSISQDSSTSTATAHSQNPASSPGARNRARALTLTTEGSETSHAGEPGTYVQGMNVLAAPFLYAARSESEAFIAFYTLLTRECPGYIRGAMDGVHKGLALVDKVLATVDSKLSGYLHSKGLTAEIYAFPSVLTLCACTPPLPEVLRLWDFLFAYGPHLNILCIVAQLMGMRDQLMSSPSPNKLLRSFPSLQADKVIERTLWIIERIPDDTYAAIVVHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VXZ9</accession>
    <name>H1VXZ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotically up-regulated 65 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03513</name>
        <name evidence="4" type="ORF">CH63R_08965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007445">
        <property type="protein sequence ID" value="CCF45111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155962.1">
        <property type="nucleotide sequence ID" value="XM_018303939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VXZ9"/>
    <dbReference type="STRING" id="759273.H1VXZ9"/>
    <dbReference type="GeneID" id="28868046"/>
    <dbReference type="KEGG" id="chig:CH63R_08965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08965"/>
    <dbReference type="eggNOG" id="ENOG502S2MG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028361_1_0_1"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="2">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF45111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="466" mass="52238" checksum="6A7AB9D6253B32D1" modified="2012-03-21" version="1">MPSFRSSRRVTGLKDSDYDHEINLVNHDERVASPSIETIGGATRVSTGSQLLRDENEEGDHDANTNTNGETGHNAGVADSPRQSIDQERNQHPKPAKRQKASALELQVTTATTAPSIEIEGPTPHEASVPARSGTQRTRPTTAERETAVDVLWENERGCIACGVALFSGKALGSLDPSPWQNQFHKTSPTTTKTAQVPDPSWEWAWPEWRVHRPEGVAMDQFGWQYSFMFSKKFSWHGPKWWNSFVRKRCWVRKRIKKKPEDISDDPHMLNSDYFTVMPANHSRSSSIAGSRRGSISKTSVQTSMAEEEKPDIEDVRTLMAVLRASRIDREKIEAVENYLSHARDNLEHLQDEMHDIMGIFVFQASRRLLLSRLTQIYDDAVATDEQQGGMDKAKERKEHLAAAIKHADEEVKRLSYWSDVKGLAENGEAKHAVAEDEGWNEGWQGVDQSGPAHANFGALPGSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYC9</accession>
    <name>H1VYC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AT hook domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_14387</name>
        <name evidence="3" type="ORF">CH63R_01948</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007558">
        <property type="protein sequence ID" value="CCF45241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VYC9"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01948"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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            <begin position="1"/>
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            <begin position="180"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="32"/>
            <end position="53"/>
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        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45241.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR13222.1"/>
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    </evidence>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009078">
        <property type="protein sequence ID" value="CCF46801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H1W2T8"/>
    <dbReference type="STRING" id="759273.H1W2T8"/>
    <dbReference type="GeneID" id="28871276"/>
    <dbReference type="KEGG" id="chig:CH63R_12195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12195"/>
    <dbReference type="eggNOG" id="ENOG502S7HF">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
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        <property type="entry name" value="COA6_fun"/>
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        <property type="entry name" value="COX6B-like"/>
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        <property type="entry name" value="CX6/COA6-like_sf"/>
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        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
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    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="29"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF46801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15823" checksum="A5B29D1D1AD94166" modified="2012-03-21" version="1">MGLFSSFQSEETRRAEEVRTGARAPDRSERRKCWDARDAYFGCLDRNTIVDALKDDTKARKACPTENADFERDCAAAWVKYFKQWRVADIQKKQRIAQLEAENAVKMDVTTSFADHAAAPAKGSATSKADLQDMLAARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4F6</accession>
    <name>H1W4F6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide:quinone oxidoreductase/flavo-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04132</name>
        <name evidence="3" type="ORF">CH63R_06946</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009645">
        <property type="protein sequence ID" value="CCF47369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156699.1">
        <property type="nucleotide sequence ID" value="XM_018301921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4F6"/>
    <dbReference type="STRING" id="759273.H1W4F6"/>
    <dbReference type="GeneID" id="28866028"/>
    <dbReference type="KEGG" id="chig:CH63R_06946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06946"/>
    <dbReference type="eggNOG" id="KOG3851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_2_2_1"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF47369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="453" mass="49298" checksum="D1370FB732347877" modified="2012-03-21" version="1">MISNRFKVASRHVKRAGVFAHNSSKLRGLATAAPVTSASRNHKVVVVGGGSAGLTISHQLLRTGRFSQDDIAIVDPAEWHHYQPGWTLVGGGLKSKQELRRPLNSLIDPKLKFYQQAVSTFAPGENSIKLGSGDNLVYEHLVVAPGIKIDYGSIKGLPEALADPNSLVSSIYGYDTCDKVFGTFEKLQKGNAIFTQPAGAIKCAGAPQKVMWLALDYWKRVGLYNASNSVSSPIKISFATGIPAMFGVPKYSAKLEELRKERGVEGLFQHDLTAVEGNTATFARPDGKERVTKKFDLLHVVPKMGPHAFVKDSPLADAAGFVDVDQATTRHTKYANVWSSGDASSLPTSKTAAAITSQAPILVSNLLRSLDGKEPEPKYDGYTSCPLTTEYGKVLLAEFKYGGVPKETFGDLIGFDQAVPRRAFYHLKKDFFPWVYYNSMVKGTWGGPNGWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQI2</accession>
    <name>A0A1B7XQI2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150543.1">
        <property type="nucleotide sequence ID" value="XM_018309571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQI2"/>
    <dbReference type="GeneID" id="28873678"/>
    <dbReference type="KEGG" id="chig:CH63R_14597"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14597"/>
    <dbReference type="OrthoDB" id="10613358at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="295" mass="33320" checksum="8B6DEF2B0CD08143" modified="2016-11-02" version="1">MGESRVDRRQRARMIHRFSKTLEQGVAELTLLDEIDPDREYLKHLGWSDDIQDEEDWMASWEMKGRFKQYLNANLKKWRTEWVDKGKPKEDRTESQAEEESAPGQEAPTAADAGTAAKESGQAATLHHPQETTTGSVQKVPEPKPSEPATDSKPTEGPDSIPGSFPHAPPPPPPTTLFDTSSVADYLKIGRIEKDHFDPAQRQTKNLKASTPRPQDEDTVIDRGLAELAARMTISAPETQRSVPCISDQASFEGRHQEPKRPAAALLSTAEDRQRFLDWYRDNYHRSEAKRFGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQK5</accession>
    <name>A0A1B7XQK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_14610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150556.1">
        <property type="nucleotide sequence ID" value="XM_018309584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQK5"/>
    <dbReference type="GeneID" id="28873691"/>
    <dbReference type="KEGG" id="chig:CH63R_14610"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14610"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="16750" checksum="CA125ECCC394965F" modified="2016-11-02" version="1">MRPYIQQFALNTTLTLCYGIRMDAVYDDLLREILYVGSAISLLCSASENMQDYVPIMRYFPNNEKNKRSKELRDRCDAYLNLLLDKVREMIKLGTDKPCISAAILKDEETKLTGVEVSSICLSLVSGGFERIPGTLTSAIGSLSTPEGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR05</accession>
    <name>A0A1B7XR05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150711.1">
        <property type="nucleotide sequence ID" value="XM_018309468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR05"/>
    <dbReference type="GeneID" id="28873575"/>
    <dbReference type="KEGG" id="chig:CH63R_14494"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14494"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7649" checksum="484BBB32A9248D60" modified="2016-11-02" version="1">MVGSNRECPRCIPGFTLNWIVFRGGFKTSKDADSAATHLNMVCQKWNDLDVGVKSDWIKNLADKTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTL6</accession>
    <name>A0A1B7XTL6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151614.1">
        <property type="nucleotide sequence ID" value="XM_018309296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTL6"/>
    <dbReference type="GeneID" id="28873403"/>
    <dbReference type="KEGG" id="chig:CH63R_14322"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14322"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="587" mass="65838" checksum="34361B5554BC7C30" modified="2016-11-02" version="1">MATPTVVLTAQTGGLLLATILIVGMICYRFALPTPLAGIPHNKHSTQRVMGDLPDLAKFNKETRLFWAWLTMQVEKINSPIIQVFMAPLGKPHVVISDYREAHDILVHRHKEFDRADFFAETMGPLAPEGHILFKSDDKFRLHRKVIGDLMSPSFLQHVAAPSLYVNLCKHIQLWDAKIALSQGRPFEAMDDIYYSALDAVTSFAFSDNFPHNATGSRVEFYSALPQSSLTIPDDEDAPVVFPKSPITDDFVEALRDLSLVYDEALAAPLPKLAWFFILRRESTKKAVQVKDSVFGKEIDLGIDRIRGGKDGSRVKSALDHMLFREATIAEKEGRLPDFHRRMIYDETITFISAGHDTSSTTLCWGIKRLADNPGIQEKLRKQLRATLSAASSEGRWPTHNEILRTSMPYLDAVVEEMLRLAQPVPGLVRQATCDTQILGHFVPKGTQVFMLANGPSFLSPAMLVEESLRTQQGRDSKESLKMWKEDGSMASFMPERWLVPAPAGTKAESTFDGFVFDQTAGPMMAFSLGPRGCFGRRLAYMSLKLLLTLIAWNYELLPCGENLSSYTAHDILTNRPDFCYVRPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTL7</accession>
    <name>A0A1B7XTL7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151611.1">
        <property type="nucleotide sequence ID" value="XM_018309293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTL7"/>
    <dbReference type="GeneID" id="28873400"/>
    <dbReference type="KEGG" id="chig:CH63R_14319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14319"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="86"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="270" mass="29169" checksum="B9FEBC19AF5547E2" modified="2016-11-02" version="1">MASSLLAALPGYSTLEYHFSGSQNRTTSAGVAVYNSWTLSLVYDRLVLDLYLSYVWRCPKPVVEDLYAKVIAQASGTLEDGGLRIIDIGVGTGYFVSHAPIPPKASLTLFDLNQSCLDAASERCRTTHKARGVLVDVDTICGDFLAPESSSGSVYTHLGGSERSIDLIFTTMLLHCVPGPPARKASALARLSRLLKPTTGTLAGVTILGDGAAHNWAGRSLMFLHNLMGWFGNSQDDEMAFVRALEDAFEIVEWKVVGAVLVFQARSPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU91</accession>
    <name>A0A1B7XU91_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151859.1">
        <property type="nucleotide sequence ID" value="XM_018307442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU91"/>
    <dbReference type="GeneID" id="28871549"/>
    <dbReference type="KEGG" id="chig:CH63R_12468"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12468"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="359" mass="39158" checksum="F1A5F6079B6647E0" modified="2016-11-02" version="1">MANGIYIISVMLGNTLIPTISGVQAEAQGWRWAYYTTAICLTVITFVFLFFFEETKYVPVSVGQSSQAGPHEVEGMKEPPASATSKLDGSTIVRLGHRATATTLEPPQMKTFRQRMQFLTPTSEPLFRGFVTPFRTSMLLHVLFTAVQSANAIFFLVLMSSVNPIVFSAPPYSFGTAGVGLMLVGPFIGNAIGSLYGGFCGDWVAVRLAKRSNGVFEPEFRLYILVLPAVLMGSGLAIYGVTLDRGMHWIYPSIGSAMYAFSMGAIMDISFTVVIDTYTDITADCFVFITFIRNAGTIALPFGIVPWLDSMSLTYIFVICGCISSSIALLFIPLVIWGKAIRKASGHRYEALRVEVASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVJ3</accession>
    <name>A0A1B7XVJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein Het-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152289.1">
        <property type="nucleotide sequence ID" value="XM_018307872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVJ3"/>
    <dbReference type="GeneID" id="28871979"/>
    <dbReference type="KEGG" id="chig:CH63R_12898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12898"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601115" evidence="2">
        <location>
            <begin position="29"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="762" mass="82855" checksum="F9856E96F2DF300E" modified="2016-11-02" version="1">MASSGLGRGSIFLALCLLLVLLPGRAAAFGAGNIPSIAQVEGHNWRHGDIEDMLKTIAFLHGKKWTSMLVSRVYFGNWLRDYSQAVDVGSLKGVNAPTIRILVWVLSFMAFGYATEEFEVTEERLGVYRPEEHIDNPLGYADGMDARKFDPRLRGPVDPIETRIDPRTGMKNYIANESGGWATSAGYLRFSFARSIHFGRVYTSGSRGSGKEADLCEALRCLGQALHCMEDFSAHSNYCELALRELGYHDVYPHCGAATEINLNGRRVFPLVTGTFGAVDFLHSVLGEATDHFTQSEVDEMNVALQNAEGMTANLTGGGTGSRGFLGLGSSKPNDFISLVSQLPGIGGDLAGQARDLQSRSAAQEQQNTRSGGDLSRDSANQVPGMSTNFDPVETARKIYPILQFRDKIVKSISNLISKIPGLEKLLDHISETLTAFILGLLAPFVRPIITQVSKVLKDGSSTVIDASSNSQLEPWKNPSCDDPTHSMLSKDHFTNILNSCAGRVAATILQYVVPRILYAWENPGVPVDEVVDDVLRAFHHPAARDDRIQIQRDMFETVRKWVNESSHKHELSHLLSSESVKTGKNHILSGGNSTKSVGGPGHTHSHGAFDGFGELGHGKVQGSLWNQIRTRDLNSMEGDDRKPLSSSPLPPSRPDYGYHESQGGSSHHYSASQSQGHASSYYSQPEPQGYGQQPPAPPAGQWGHPQPPQGYGGPGYGPGPGYGGPGYGGPPQPQYPPHHQQPPAPHHQQGGWSQYPGQHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWJ6</accession>
    <name>A0A1B7XWJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yhr209w-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_13263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152654.1">
        <property type="nucleotide sequence ID" value="XM_018308237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWJ6"/>
    <dbReference type="GeneID" id="28872344"/>
    <dbReference type="KEGG" id="chig:CH63R_13263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13263"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="55"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="324" mass="36206" checksum="0AF169B34800BD85" modified="2016-11-02" version="1">MNAPITAPRPGVSHPATAAIAKEAKHYIAHRPPYPESMWELWTNYHQGPLTSAHDIGAGSGNGAEGLLTHTSSPPLKHVVLTEPQEVNIKDCVTRFHNRFPDTSFAYRNCRGEDPWSPPAGLDHVDFVMACESLHWTTLEPTLDNIANSLREDGTFAAVLYGPFPAITNSAPANAAFKAFLADHAARLLRQDWMNGNWKRAARQMFHGMECVALRDEAWKDVKRIAVNCRNGWYAKDYEPLEGTADPVGHLGTCERIAVDDSKDWQISAPVEWLKQSLQSMRFGFSEESWASPHWQAIEHEMGDGALELEWQVQMILARRRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWQ0</accession>
    <name>A0A1B7XWQ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Importin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152715.1">
        <property type="nucleotide sequence ID" value="XM_018308298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWQ0"/>
    <dbReference type="GeneID" id="28872405"/>
    <dbReference type="KEGG" id="chig:CH63R_13324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13324"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="309"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="425" mass="46196" checksum="06D45026918F513A" modified="2016-11-02" version="1">MGYIANTPEDRLERSDSKNPKTTCKGLTGSGNLCRNPVTPAKGKALSPTLKEESLYCHHHKDQAASRSAQSSPGPRMSGRPVLEERTSIDTLADRLGLVDIGSNLSKKQKRPQGGRPSGGRPHPATSKPPAAHSRPPKKEKQLHFCFCFTIPIDEVQEESQPAPRPQPRPVQNGGSAAVPRPSSQLLSPSNGGRPTASTSSHSRKSSQPSPQPLSTSQTAQYLSLIPPTTDPQTASALMAELARPYGSSEEPGYIYMFWITPTSKKEAAPLQEARSLLAPPSPARGGGRQRRSSDVVSAFAKANGGASADNKMLIKIGRAANVQRRMQQWTKQCSYEIEVLRYYPYIPGASAASGEQPRMTPHVHRVERLIHIELSGMGLHAGPITCAGCNQVHREWFEVQTSKKGIGAVDEVIRRWSDWDETQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX40</accession>
    <name>A0A1B7XX40_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152846.1">
        <property type="nucleotide sequence ID" value="XM_018306005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX40"/>
    <dbReference type="GeneID" id="28870112"/>
    <dbReference type="KEGG" id="chig:CH63R_11031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11031"/>
    <dbReference type="OrthoDB" id="4837859at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="97" mass="10529" checksum="8B8B2409E03E6039" modified="2016-11-02" version="1">MFDQSFKTESQISLIGHDTADSKPSTTERKEAKKSLFQRLQSTKRAEISEEDLLKYTGMTKDGLADWARDRPGVGKNQRAEGASGPPEAAGIVIGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXM9</accession>
    <name>A0A1B7XXM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153018.1">
        <property type="nucleotide sequence ID" value="XM_018306177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXM9"/>
    <dbReference type="GeneID" id="28870284"/>
    <dbReference type="KEGG" id="chig:CH63R_11203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11203"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF66">
        <property type="entry name" value="INTERFERON-INDUCED GTP-BINDING PROTEIN MX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="60"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="602"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="699"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="900" mass="101629" checksum="274388255BE0BC44" modified="2016-11-02" version="1">MGSLYELPATSRNPSTNASFRPERDMAPNIDSALGTADMANEQRGLLELIDKLQFAQLDNVKLPQIVVVGDQSAGKSSVLEAITGTPFPRDAGACTRFATEIRLRRSNEPSLNVSIIPDKNKTFKEQERLKQFGGAVDVGMSFESLMRSAVDLIAPKNIPGRFAARDILVVEKRGPDMPLLTLVDLPGLVKNANNDQSMDDIKTIETLCDRYMKSSRTIILAVVGGNTDYVQAPILTKARHFDPSGGRTIGVLTKPDLCESIGLEDKFIELVQNRDKQNYFKLGWYVLLNPGPRDQGQPWPSARERRQREEEFFGRGKWRALPSSMCGANALKQKLSVQLQRHIGRHVKTLRKQIQTALDDCDTELKSMGTGKDTVEEMRIELVELFSASKELVIPAVYGFYKNPPRKNFFRATADPRGTPAQNLRARAIEENEKFSHRIRQNGRKFGFSSSTAPGTADGVTISESSKREFVGREVEMLLRQIRGSEFPMDPKPRAVYMLFQSYSENWPKLAQEHKDNLGVVCNEFLSEVIDFAWPQRMREPLRYQFLDVQMKKLMADAQQELEHLTQDMNLEIQPYDPEYEERLRKWQIESSKDGATYTEAQEVCEKMLIFYELAAKTFIRNTITQVVERHLLQGMYSIFNSVEILSMPNETVEAIAAENKETRDRRMTLKTQKTAIEEARDICASLAMRKELRMYADEDRDLEDNSSDSDEDKPRQTTTRKPVNNNNNTTTTSNTIPSRETNRSTRSRDEREERYERPAARTQPSAAESLATNGNHGYSSQQTPAQAPPPPPPQAQAPAPHRVERAEPPRTNTSNSEWEEEYYRAPSQQGAPAQAPPPPPRPQKLRPEEAASDAYSHRSASSVSEQQHANGYGSYHDQGEYAPSSTRRATAKKLFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYH9</accession>
    <name>A0A1B7XYH9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">EC34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153320.1">
        <property type="nucleotide sequence ID" value="XM_018306479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYH9"/>
    <dbReference type="GeneID" id="28870586"/>
    <dbReference type="KEGG" id="chig:CH63R_11505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11505"/>
    <dbReference type="OrthoDB" id="4820484at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="144" mass="15474" checksum="3E6988A33FB3D98B" modified="2016-11-02" version="1">MRIVVVPATTSCINQPIPPVILMLSDLNSPDKLLLTHTRFYPTIYTPSSHKATLTHSLKMRTATVTAAFASLLMTVAAAPQGFNCQSHGFCTYSDPNCNFCLNIAGSAKLDICHQFNPAYTSAPGDISRGPSGADFQCMLTCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYM7</accession>
    <name>A0A1B7XYM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serin endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_11586</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153401.1">
        <property type="nucleotide sequence ID" value="XM_018306560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYM7"/>
    <dbReference type="GeneID" id="28870667"/>
    <dbReference type="KEGG" id="chig:CH63R_11586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11586"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601204" evidence="11">
        <location>
            <begin position="18"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="141"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="367"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="606"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR04883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="905" mass="97481" checksum="0C47786F8C7F094D" modified="2016-11-02" version="1">MRPRLLFWAATLGVAEATNRSQLGRRQDGAQNSIADTKKFIVEAEPGTVLDDLSRKIEATGSRVLKSFDSDIFSGLSVESETDNVDTLQNVGEVAQAWPVKTYRLAPVISQASFGDDATAKNWSIHFSTGVDKLHEAGILGKGVKVAVIDSGVDYRHPALGGGFGPGFKVAGGYDLVGEEYDGSNEKNPDGDPLDSLGHGTHVAGIIAGKSDFYVGVAPEAEIVAFKVFGAFEGTDEDTLVEATIMAYESGADIITASIGRANGFSDGPWATVASRIVEQGVVVTIAAGNDGDEGPFYASTGSSGKEVLAVASVDTSRVPARPWHATFNLNGEASTTQLAYIPPVNRALWNTTGLPILPLGFDTSNPAEACSPLPDTTPDLSDVIVLIRRGTCTPYVKQTNVEKFGARHVLFYNDNSRPFELVANSAYKSQMALIDAKAGAAIIETVKAGGSVTADFTVPADGNWAVGFFDAAGGIPSQYTSWGGTYELEIKPDIAAPGANIYSTYLDGTYKVLSGTSMATPYVAGVAALYISKHGGRSVHGKDFAKKLSRRIISSGESLPWQLFEPQGLPTDFGFLAPVTQVGNGLLNASKLLDYKTSLSFEKFALNDTGSFSRYHKVEITNDGDSPVTYNFTLEPAGGFFAQGRTSGLLADILDVKPFSLVPTVTFPSGVFRVSPGESKEAQFNFIFPESVDEAKLPVYSGRIIIRGSNGETVAVPYMGAAFDLKVQMRGTMFPPSYPFQRSGPGSQDIDAYHTYAFNTSRAAQDFPKVNAKFKWGTKELRWDIFDKDYEESDWTYPPVVGENGYIGAATSSTYASSSVTFDPTTMDREKVLPFPMRGIERTTTWSELTDRFWWLGKLANGSYIAPGNYTIRFAALTPFSNPEHSDNWDIWETPQITILPYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y057</accession>
    <name>A0A1B7Y057_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein 585a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153907.1">
        <property type="nucleotide sequence ID" value="XM_018307066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y057"/>
    <dbReference type="GeneID" id="28871173"/>
    <dbReference type="KEGG" id="chig:CH63R_12092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12092"/>
    <dbReference type="OrthoDB" id="5242988at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="905" mass="99468" checksum="E3104C96D77EB01C" modified="2016-11-02" version="1">MSRPLPREAMNERPRKLRKQMHHGTLYSTPPVPSRPDAFASLPPCWPPVDWSLADFYPGPAIYGEHAWSQTHGVGQTDHAFPKPLPRDEQSALAFFQPVSPLAQAPLPPAWSTVSSVTFSSPSVVSQPSSAGSGCSPTRRDFPYEWPTRKASPSATSSVTQTATEPSGNRAQSRFVCLGPQCDETFDHEKDFKSHCKTVHTHTCNWAGCDQPSFSTKDGLTWHVKFEHLLICPAPGCTETSFQTKQILESHIRCAHPEASGEGNGKGKEPAATSKPKAQAMASSNSSQGSNALAAPSQDSNEDRAIKQILSVAVSKKKCREQLKNVVEKKYRRQNADSPSDFSRAQLCRMVENASFPLVWEHGVLPFLVEFIPKWCGPNHVVSVTRGKTPGSRRVCIMTKQKPSRTRRIIIAAHVRDLLPENHRSTITFAFVTGAVDRMVWARGLSKEMPDEVCMARNPYYFKNPCMGDSIGIHGTDDFKESTSTLGPCLLVGGGSYWLANFHPFVDAYQHRASVRVEHPSPSDRASCIDERHDTMPDTDFTLGSLTATSGIDLKTTRISHDPYWEELDKEAPLIVTDWILIASKTRQANILRRFPSDTMPLLKEVPVKMMSVVTPGATVVSTGRTSGQRRGQICEIPAYVSAEENGTGKATREWFVEEPYPFDDEESWIRGGIGVEGDSGAAIVDADTNALVGQLWGRNKYFGAGPRLTFFTPIGDLFDDIQEKCGQQARPQLPQYRDESDCYPVDPSCRQCFDLRTYLDSRRNSRESLRSMIGRNESDHGDLTSIEGTSELATPKDHAFGSRYSGVEEVGSSFTSIMSPSALHPSAFASILSPSATHPLALTPQPGTPGIVDIKSPYALTLSTEDLYDEEAYTNTAGAASGKRAAAAPPVRSSIQNAKRQRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0P6</accession>
    <name>A0A1B7Y0P6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Linoleate diol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154109.1">
        <property type="nucleotide sequence ID" value="XM_018304685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0P6"/>
    <dbReference type="GeneID" id="28868792"/>
    <dbReference type="KEGG" id="chig:CH63R_09711"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09711"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127056" checksum="D32A4DDB73AB0657" modified="2016-11-02" version="1">MKSQRNGSLSAPNVEEHEHSTAISSNGVSARDEKRPQPGPSRASARYGSHDVRKSASASLKDASKRPMPTQYGDGTYPKEIIRPTMVQNLRALQAADVKTLVQIIKSKLKREKIQDDKTMIMERTIQIVAKLPHNSRLREQLTNTFIEELWDSLDHPPMLYMGDEFKYRRADGSYNNPMFPQMGAAGGPYARSVKPRIITLGAMPDPGLVFDAVMGRTDYKKHPNNVSSILWYWATIIIHGKYHLPTPVFLVATKQPDLFWTDYRDSSKSKTSAYLDLSPLYGSNQEMQDSIRTFRDGKLKADSFADKRLIGMPPGVCVILIMFNRFHNHVAEHLAVINEGNRFAPPGKGLDEESAAKAWKKYDEDLFQTARLVTSGLYINITLVDYVRNIVNLNRTNTTWTLDPRQEAGISAGTPDGAEAGTGNVNSAEFNLCYRWHSCISDKDDKWIQKFYGKLLGGAKGELSPQELACVFGKFEKSIPDDPGQRTFADYERGEDGKFDDDDLVDCISSSIEDCAGAFGARNVPQVMRPVEIMGILHGRKWNVAGLNEFRKHFSLKPYERFEDINSDPAVAEQLKNLYQHPDYVELYPGLVAEEAKTPLTPGVGIAPTYTISRVVLSDAVCLVRGDRYYTTDYNPRHLTQWGYKEVDYDLDINHGCVFYKLFLRAFPNHFKGNSVYAHYPMVIPSENHQILTDLGRVDQFDFSQPKFTPLRTNIESFGGAKYILENQDRYKVTWDEGLTFLMGEGGSRFMLSGDTDFHAGQRKCMQSLLYSDGWDSHVKHFYAEITAQLLAEKSYKLAGQTHVDIIRDVGNLAHVHFASRVFNLPLKTHQNPKGLITEQEMYQMLAAIFVCVFFDIDPAKSFPLRQKAKEAATMLGKLIETNVKITTKVGFRGLFTGSADKTDPLASYGTNLIKGLSKAGLSAYDIAWSQILPTAGAMVPNQAQVFAQAVDYYLSPPGAAHLEQIHETALSPSTKESDALLLGYAMEGIRLAGTFGSYREATQDDVIVEDDGREVPVRRGDRVFVSFVSAAKDPENFPRPEEVNPLRPLDSYIHYGLGPHACLGRAASQVALTEMFRTLFRKKNLRRVPGPQGILKKVPRPGGFFVYMKEDWGQIWPFPVSMKVMWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0T9</accession>
    <name>A0A1B7Y0T9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154142.1">
        <property type="nucleotide sequence ID" value="XM_018304718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0T9"/>
    <dbReference type="GeneID" id="28868825"/>
    <dbReference type="KEGG" id="chig:CH63R_09744"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09744"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="652" mass="71711" checksum="33257C08056EC0DD" modified="2016-11-02" version="1">MNSPNRTSPNTPSGNRASLRDLLRSRQRSRNGVRGNPKSCLPCRERKVKCDKKLPCSTCDKRGHPDLCDYDDKTSRPSLGGATSPARSARGTMQVSGGRSETAFDNQQMDTSVGDANQELGDGLSSALPTESLRVHRAPRAAASTSDVTASGDGSPLFLADASVVNMARRRSIQSRNDPARQSAFETGILPLLGVSEDTHTSLPSYQALPGDQEIIRLFELFRRRVQPFHLITYDLDKVEEKICRLVNARSDPDSGSSSDDAGWLCLLHAILAAGAQFSDMGLEDRIAVTQRHTKQAFDLLRSTDYLARPSKEAVQTLLLLGNVLQNDMKPQAAWVLGGTTIRLAQCLGLHRRIGRPPTSPMPDEETRHLRLAIVWQDSLLALTFGRPPASYEMDFEEDLPRLDDARADGHGLSYLQAMSWLCHAALRHLSSQSDVSGQLLSTLNDIKAIGDSLSPHLIDPKRSKTIPQIQEHYAFELHRHFVISTLCRPCVSSSGAVELGENDKAMILEQFQESLRKSARAYIRLRSIAGHAKRSWAFIHNGLTSVLLLSLMRETRYLTETRTLQDELISSLSNEEGEPDPSTDTGAVGHLSGTLQKALKALKTLRTLAERDASGQNLEAVSNTNRAMPDSRDVRPETMERSGTGIAEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y145</accession>
    <name>A0A1B7Y145_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154249.1">
        <property type="nucleotide sequence ID" value="XM_018304825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y145"/>
    <dbReference type="GeneID" id="28868932"/>
    <dbReference type="KEGG" id="chig:CH63R_09851"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09851"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="163" mass="18069" checksum="58D10748CC97A4BD" modified="2016-11-02" version="1">MHVKKHPYLNLSSLDVCPVEFPMMALAEPVRQSSYPSSTPEVGRLRRHLGFNPWSGASAQIDRLGCRASRRCPSRFTIRCPSHETQGEGCPSFRVINQGFRTTLNRRAAAACPSAPLSDLMLDDDGVRARIRKPPPQLLADDRDEGARLRRSMASSNRGQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2E8</accession>
    <name>A0A1B7Y2E8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154707.1">
        <property type="nucleotide sequence ID" value="XM_018305283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2E8"/>
    <dbReference type="GeneID" id="28869390"/>
    <dbReference type="KEGG" id="chig:CH63R_10309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10309"/>
    <dbReference type="OrthoDB" id="4741350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="43066" checksum="EAC40313DB5551C8" modified="2016-11-02" version="1">MTPPSRVRHATHAPPTNRPPESHHAQLVSDLAPDNLIVGWSRLENGVFIQRKPFLFFGDQFVSNPLPAQFHPSTGASAIEPAPMSLPPTRSCLVLLICIQELLANVYKTATRSLVISETTLGIPLSKPPPHRRGNDRMATRRWYLETSPDGRYQFVSLKRSRSHHHDRRHHHHHDPQPPSPSPPPPHRCCRDDCAHVTREEWNDLVERERKLREVNDGLARENYSLKCNLQASNNEGQRLSGLVTALQAEHQLLREEIASLRCSIDSSSDNAAKYLRENERLKHKLSKVEKERDGLLARVRELSRHAQHGLLERIEELKRLALTLERKFDAVDDHNKRLRRDLEAQRCFIADQEVKIRLYERVLRRHGFIRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2M2</accession>
    <name>A0A1B7Y2M2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154779.1">
        <property type="nucleotide sequence ID" value="XM_018305355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2M2"/>
    <dbReference type="GeneID" id="28869462"/>
    <dbReference type="KEGG" id="chig:CH63R_10381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10381"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="72" mass="8351" checksum="56EC4AB99E329FC9" modified="2016-11-02" version="1">MASGTRSRTMRFYKAHDESGSATLGESAVCAKTDRAESRHPIINKLAELQDEMARRDRDKIVWRLIQYRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y390</accession>
    <name>A0A1B7Y390_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_10582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154980.1">
        <property type="nucleotide sequence ID" value="XM_018305556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y390"/>
    <dbReference type="GeneID" id="28869663"/>
    <dbReference type="KEGG" id="chig:CH63R_10582"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10582"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="796" mass="87889" checksum="E9D277B3EAF03A3A" modified="2016-11-02" version="1">MANTKASVVSTSAVDDDAPSSVAATGRGVDASKLDRPRVLEDDKSDDGLKTNDPERNESEDERQLVNGAVVIRDGNDVARYVVSTQDDGDASCTFRSFIIGSGLTALAACINQIPSYFYKPVDVSFASVFLCLMAYVIGVTWSVVLPRRHHVEQYLPSQAKWLGPVVHFINPGHFGLKEHAVASILSTSSGNGAAIVQVFGAERLFYNRNTDAATAILTVFSASIFGYGLVGILRSILVHPSEMVWWQCLPMISIYQTLHREPEGNNKDRLRMFGFTSIGMFIWEPIASYIWPWLNGISIPCLASMKAAPPTRKVLMTIFGGISSNEGQGILNFSLDWQYITSRYMSLPLLQQANSWVGIVLSYIMCFSLYYGGAWGAKKFPFMSTAMFDGKTGKVYNQTAVFGQNAILDPEALEIHGLPRLTASNVWANMAAMAAIGALLTHISLFYGPLIKRSLKQAWKKEETDPHYKIMQEKYKDVPMWWYIAILLVGFFTGLGAVIKGNTTLDAWAYVCAIGDQLLGCIVAPFSLCLYGLLGTSVATNNLSKMLCGVLQPGKPVANLYFSMFSHEVTVLSVFLSTDLKMAQYLKIPWRTMFLLQTWGSLFGTALNYVIMDTIVANRREILLDPIGNQVWSGRKIQSLNTTAVTWSLAKYVYGFGKDGYGWIPLSIVIGAAIPVILWLVSRKYKTIYGWEVRKLVTPVIFHNASETTSGTTSVIWSQVATGLWSQWYMRLRHPAWFGKYNYIVGGGLDAGAKVMMFILTFAVAGGSGKEVPFPTWWGNPNSSSKQYADYCGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y393</accession>
    <name>A0A1B7Y393_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154953.1">
        <property type="nucleotide sequence ID" value="XM_018305529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y393"/>
    <dbReference type="GeneID" id="28869636"/>
    <dbReference type="KEGG" id="chig:CH63R_10555"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10555"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="170" mass="18990" checksum="F494761517DB4CA5" modified="2016-11-02" version="1">MGEYINSTSTRAWSERTCGYTFPGRALNMGTFQRDMEYAMSSSKEGANLAIIIESAILYETSDKPIGRRSGITFDVLKIDKETEFEYNSPPHFDAYTIKWYWCAKTFHNLSASQGEVDIGTTSSEPLQVNADYKVDDPFGLYYDPYLIVGNTSSSSALYQTPPPPILGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3B6</accession>
    <name>A0A1B7Y3B6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155037.1">
        <property type="nucleotide sequence ID" value="XM_018305613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3B6"/>
    <dbReference type="GeneID" id="28869720"/>
    <dbReference type="KEGG" id="chig:CH63R_10639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10639"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="527" mass="58621" checksum="595381C9E994F8A7" modified="2016-11-02" version="1">MGETASVSSSTTPQPAAREEPVNYGPPEEGIFKHISKFIPYFRDARNVLVFKLDVMLLAWMFLAGIMKEMDQSATTQAYVSGMRESLNLYGNELVEFNTFFSIGYALGLVPGQLIQTRFRPSIFLPLCEMSWGLLVLFTYKAPNAQTIFGLRFFLGLFSSAFWPSVVALIFNWYTPAELAVRVACFTVCDVAGAMFLGALQAALFRDMNGVHGYAGWQWLFLIAGAVTVGQGLIAFVTVPDSPSNTRALYLTENEKRLARERMGDSGVTTSKRIPAKLLRAKIRKLLVHPVTYFFLFSFAFSAWAHRANSYFVLYLESIKDAAGNRVYDTYHVNILPLGGYALQIVTNVGLNWLSDWKHWRWQISVFSAAAHGICLAVLCGWPSDHKVILAFYFLTYATNAGSPSLMAWMAEILRKEPEARSIIVAMTVTTVYVGHATIPLGAFRVADAPRYPIGFPLTTSFTVATILVQLGMLWWHRRHPEIADYGYEKPSNAHGSDEENPKLGDNETVVSGPDSKAAQVTGSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5E3</accession>
    <name>A0A1B7Y5E3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155730.1">
        <property type="nucleotide sequence ID" value="XM_018303707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5E3"/>
    <dbReference type="GeneID" id="28867814"/>
    <dbReference type="KEGG" id="chig:CH63R_08733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08733"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="289"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="734" mass="81394" checksum="31A71597383F4F22" modified="2016-11-02" version="1">MSSRRAPIAGQRRRQGTRQNRQRTDLGTTPSRIPGDISGNDSAAEHGGDTPQPHTPDGPDPAIHSPPPPPHTSTQQPGALTEQNPSHRAGVSRIVVSANGVSSYHGRTSALFEESLQERSSAVDLRPRMPDEWIEKGLVAEAARQRMILLLHQKLGFGQLEDFNYRAGTLDFDGVDPELGMHLLSLHWNRQHHSFLLTYRPAFMRDMACNGPYFSKILLNAIYFGASKFSPRREVRRDLNDVRTAGWAFRERVRKLLGDALDSSDITTIQALLVMTNSLFALGDERSAAWLYAGLAFRMIIDLGMHVDAPGLGSTRKFSDEDLEIRRRVFWGAFVVDKIQSLYQGRPASLKESDTLVPIKFLDTFEEFENWKPFAYSTDATSYPGSPAFSVSTFTYLCRLSVVMSDILSCIYTERAFDKSATELSTMLESLSSKLAAWKEALPTHLVFDPKNDDQVPPPHVLSLHAMFNVLTILLHRPFVADGHLYNTSRSISVNSFITCASAADSIVGVLRAYNRVFSVRHAPYLISYATYVAATIHVRIAAKRSTESEARERLETCMSVFRENQETNWAVRRAKTIVEGLMTRLGVSLTRVDGNERQRSNAFPVSTANRDAPDALGNPNDRVRLSMTDEARPPQTVLENVSPSMGWSDIDGIIQSFVRGQEHNTVAADVNQTDLNQQPVPSGTGLQPANFDSSSFIGNQTWFQGMPEGDGGAASFDDLLFGFNGSALDSMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7M4</accession>
    <name>A0A1B7Y7M4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156580.1">
        <property type="nucleotide sequence ID" value="XM_018304557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7M4"/>
    <dbReference type="GeneID" id="28868664"/>
    <dbReference type="KEGG" id="chig:CH63R_09583"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09583"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="292" mass="32189" checksum="D9C3A1227FEE9813" modified="2016-11-02" version="1">MTTTAITPELLASSQFRATEDASWLKKVLDMSAFDHYDQIVALSQGMINNAMATIDTYDDNPLDPPEKRQYNKEMREWLQKHFQVPGDYRPERIFAKFADAHWSQVSLVTNPFNKDDLKSVYEQWKNSSEKNASIGNAFEKVFQVIAVQRQNQGLTTIGTRFNLDAPPGVCLLSKPPSPWSIKATHTDLVHDQADISVVLDAALVTPVAVDLGSKKLSSRLVKVYLKISSSTPGTPVAIQPGGTIQVDIQSVTAPARSNPPQIQAAESWCDSKAQTLPGQAPFRVLVPIALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7P1</accession>
    <name>A0A1B7Y7P1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156493.1">
        <property type="nucleotide sequence ID" value="XM_018304470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7P1"/>
    <dbReference type="GeneID" id="28868577"/>
    <dbReference type="KEGG" id="chig:CH63R_09496"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09496"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="6">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="429"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="5">
        <location>
            <begin position="735"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="837" mass="90835" checksum="6070B974592A41F7" modified="2016-11-02" version="1">MDPSQRVVIIGAGIVGTNIADELVARGWTNITVVEQGPLTMPGGSTSHAPGLVFQTTGSKTLSSFAKYTVQKLLSIGCFNQVGGLEVAETPERLEELKRKHGYASSWGIEARLLTADECKSIYPLLSTDVVLGGLHIPSDGLALAANAVQLLIQRTREAGVRYLEHTLVTGIEQSDGRVTGVATRNGVIPADLVLSCAGFWGVEVGAMVDLPIPLLPVGHQYAKTKPVPAQKGKKLAANGAQLPILRHQDRDLYYREHGEQYGIGYYGHRPLPVVAATLGETPKQVDEHNMPSRLDFTPDDFAPAWELTKRLLPALAESEIEHGFNGIMSFTPDGGPLVGRAPNLEGFFVAEAVWVTHSAGVARAVAQLLTTGKSEVDLSECDISRFEQVQLAPEYVKEVSTQNFVEVYDILHPLQPRESPRNLRVSPFHARQKALGAYFLEAGGWERPQWYEANENLLGLLPDKWKPRERDAWSARYYSPIAAAEAWKTRTAVAMYDLTPIRRLEISGPGSVDLLQRLTTSDMAKEPGAVSFTLLLDEQGGVLSDIFVARLRRDLFQLAVNGPVDLAYLSREARLQTRASPAKFVQVRETTGGTSGIGLWGPRAAEVVAGISSDNLRDMPHSRVKSAIIAGIPVTVISLSFVGEPGWEIYSSAENGPRLWDTLWQAGQPQGIIAAGRSAFSALRLEAGFRTYGVDVTTEHNPFEAGLGFAIDTEKRGYVGYDAITRLSKETPSRQLRCLAVDGGRSVVLGKEPVFLDGKAVGYVTNAAFGYTIGKPIAYTYLPSTVKEGSGVEIEYFGRRIKATVTAEPLRKAPEGVSAASSSTTTTKRVPIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y922</accession>
    <name>A0A1B7Y922_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_07269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157022.1">
        <property type="nucleotide sequence ID" value="XM_018302244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y922"/>
    <dbReference type="GeneID" id="28866351"/>
    <dbReference type="KEGG" id="chig:CH63R_07269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07269"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF124">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="50"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="292" mass="32438" checksum="464858AE499A5F2E" modified="2016-11-02" version="1">MFNTSGVTTALPAPEGYVVDFGNTQRRSVLETFVTLSVGVVLALLFPFQRLYVKIVIRKRFGVDDEAAMDGYVGVHGWEVPIEKFKDFTFVRFLSLVISFPTTLIDNSPASQYNSYMNPIVYAIPPGACKMVILMFFLEINSSTDWFRRTVYFTMFVVVGSSLGILFSSIFPCNPIQSAYDLATPGTCIDTVATFKATATFGVITDMMIICLPIPMVLNLQVSTRKKIGLLSLFGIGSVTVFTSIVRLYLLITILNDPDQTWGAIFINLWVGVEANLLVMCASLSTLRLFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9K3</accession>
    <name>A0A1B7Y9K3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157289.1">
        <property type="nucleotide sequence ID" value="XM_018302511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9K3"/>
    <dbReference type="GeneID" id="28866618"/>
    <dbReference type="KEGG" id="chig:CH63R_07536"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07536"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="156" mass="16922" checksum="E214C4EA8F3AB9BB" modified="2016-11-02" version="1">MADTVPLNKNVPPLSQNNGHDALDETLTRLSKKPGVKATVILDRVTGAILRTSGQLSSFNAATLATGQGSFSGEGAAGQQQQQQQQQQQNGEEQPQGLEEFAAKVWNWVNASGTLVLDLDTEDELKLLRLRTKKQELVIVPDPKYLLIVVHDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9U2</accession>
    <name>A0A1B7Y9U2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157272.1">
        <property type="nucleotide sequence ID" value="XM_018302494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9U2"/>
    <dbReference type="GeneID" id="28866601"/>
    <dbReference type="KEGG" id="chig:CH63R_07519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07519"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="264" mass="28974" checksum="B714BEDAFF5F6C46" modified="2016-11-02" version="1">MKPQREILPAGPTAASSASSERESTPQSATGTASNAPRRRPQTKIACTSCRRRKSKCDGQRPVCSLCAGMGRTRCEYDAGPDVTRFAALKTKHEELQRRVTLFEELFRLLSMRSEGESVEIIRRMRTANIETDLEDLVKFIKNADLLMQLSSAQSDQTPSASGESSVDTHLPPMPLDDISSLLELLKSAVSKLDASARTVLLDTIRHHIDVFTSHEGGRPGSAETVKLEGMPDGEAHTEMDGGRPQEPGAFLKRLLNDDMTRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA92</accession>
    <name>A0A1B7YA92_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157383.1">
        <property type="nucleotide sequence ID" value="XM_018302605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA92"/>
    <dbReference type="GeneID" id="28866712"/>
    <dbReference type="KEGG" id="chig:CH63R_07630"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07630"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="243" mass="26160" checksum="E34316DF72FB2C03" modified="2016-11-02" version="1">MPPALPSRPLSYATAPSVLPYTLRFHPYAPSATSQVHHTHRLCVGAAVISTPTPPDKNNNSTTTTTTTNNIPPRILLLQRSAREKALPHRWELPGGAAESRDGDALAAAARELWEETGLRAARFAALVGAYQWDGAGDSAAATAVPGDQAWGLPGGGVGVAESADVVASRRDAWRKYTYLVEVETEAGGRADVVVDPEEHEAFVWATEDEARAGRCGDVVLDWTSENQRLDVLKAFEIAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBG6</accession>
    <name>A0A1B7YBG6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157896.1">
        <property type="nucleotide sequence ID" value="XM_018303118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBG6"/>
    <dbReference type="GeneID" id="28867225"/>
    <dbReference type="KEGG" id="chig:CH63R_08144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08144"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF5">
        <property type="entry name" value="TAIL SPECIFIC PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPAF-like PDZ" evidence="2">
        <location>
            <begin position="94"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="788" mass="86964" checksum="1C17C59A72B169C1" modified="2016-11-02" version="1">MSVPFHQAPALRFIEYYNTTMQFQSNLAYLKNPPAGYQQPAFDFMGALEELKHNVTAGAFKNQYDFEAMLQYLVYSVHDAHVNLYAGILSVFSYASPIPLVSASIDGKEAPKVYFADDIIGRRDNISNGVESSISAVSHINGEPVVEFLTRFAALQSVGMLEPHADWNELMDHPVQDVQRIFSIFSGSSTFYPGDILTFSFEDSSIPNWETNWLAIYNTAEYTGPLETSGDFYNFFVLGLLPDSYDEVPLPIVFRGPLGTENSPAAGDTPTGGGTTEEPGAWYNRSYGAFPQTPDIQQDNLDDESVLTGYFYEDISTGVLSIPHFNQYGLEMGTFGLALAQFIEGAKEKRASRIVIDLQKNFGGSTGIALLLFREFFPGIDPFAGSQRRSHELGNILGSAKTQYWQDVAAGTEEGLGLLADEWVIAARLNAETGRNFTSWEGEYEGPRRQNDDDFSLERYDLNNPQFHEATFDGWRLTRYLDDSGEQTRTMWKPDDVVILTDGTCSSACALFLELAKTQAGARTVVVGGAPKPGPMQAASGSRGARLYTGDTLDKDFSWISGRNESVRRLLPHDRNETGIFVDYAAFNLRDQLREDDTSTPLQFRYVPADCRLYFTVDNVYNMTALWHDVAHAAFENPSLCVEGSTGYGSRDGRANAPPESSAVPAPVPRPAVEFSVDYDPSTDNGLPAGIVTPRPSRHSAAKEAKPGLWRPCQFNGNTCAGTLVCQWVRYSCNAGGEWQEWTDLACVQRCQRLEGGDCVVDKSYDAKESAARASLVKKAIPTMVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCM7</accession>
    <name>A0A1B7YCM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158117.1">
        <property type="nucleotide sequence ID" value="XM_018303339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCM7"/>
    <dbReference type="GeneID" id="28867446"/>
    <dbReference type="KEGG" id="chig:CH63R_08365"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08365"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="56341" checksum="3D9210073103907F" modified="2016-11-02" version="1">MAASEPKIDIEKAPSAGDSQPEVLIGEVKDIHNADAALDFLRNGGDVGPMTAEDERRLKRKIDWRVVPLLFACYILQYLDKTLINYANVMGLQGDTSITGDQYSQLAMIFYVSYLAFEFPHAWGMQRFPTAKYIGIMVCLWGVVLATTSACHDWAGLVVTRVLLGVFESAVAPSLIVITTMWYKRQEQPPRMGIWYLGTGGGTIVGSLISFGFQHYHSSGFMSWQIMFLICGLITIAIGATVIMVLPDNPMTARFLSREEKIWAIERLRGNQTGVENKHFKWPQFIECFTDPQTYLLALITISSNVPNGAVSSFQATIIKGFGYTSKETALLSIPSGAVSIVSILAATNMAGRFNQRAINIICLLVPGVVGAALMAFLPEDNKAGKLIGNYMTNCIGATLPLLYSLVGANYAGHTKKVTMNATLLICFCVGNIIGPLTFTAESAPDYLPAKTAIIVTCGLAMMFTLMLRFYYVWENKRRERLVQAGGLGHVTDIEFSDLTDRKNKEFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCT9</accession>
    <name>A0A1B7YCT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158460.1">
        <property type="nucleotide sequence ID" value="XM_018300610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCT9"/>
    <dbReference type="GeneID" id="28864717"/>
    <dbReference type="KEGG" id="chig:CH63R_05635"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05635"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="62" mass="6943" checksum="54A8B987428AE80D" modified="2016-11-02" version="1">MQIEFSKSRGGVVVDQDQNQDQDLNRGLRGRRGESKVGSVGMDGMQGGKQWEGMWWMGVRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDC3</accession>
    <name>A0A1B7YDC3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158421.1">
        <property type="nucleotide sequence ID" value="XM_018300571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDC3"/>
    <dbReference type="GeneID" id="28864678"/>
    <dbReference type="KEGG" id="chig:CH63R_05596"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05596"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="365" mass="41060" checksum="8157B65664F14980" modified="2016-11-02" version="1">MSFAMPFTIRSAACPFARYFLMAGPPKVIPLCRSHRCQYSMLSAGDTFRGECGLTYRLVRPLGSDSRNNVWNAVDASRETSQYIAKGPSDGDDKSRDWLAFQHELDMQRLFAKAPMIREIVDFVPISESAGPLMILEPMPMTLWEARNTRRLTKREIKWIMRGILLGIGAVHAKRMVFSDLKMENVGVGGFDAANPNSNVHEIIVLLMDLGSISPPSDREITSLTYRSPEVHFGKPWDQSTDIWSWGVIVTPAQLAQLLQAAVDPESPGLYDNVTRGTLEEKTRAVRDRLAVDFDLHSVPFYAHDEKCRALLPPPRPDEAYMWANSMVEKGVSGEDIQFLVEVLHPDPACRLNVREVLESGHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YES6</accession>
    <name>A0A1B7YES6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="13" type="ORF">CH63R_06285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159110.1">
        <property type="nucleotide sequence ID" value="XM_018301260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YES6"/>
    <dbReference type="GeneID" id="28865367"/>
    <dbReference type="KEGG" id="chig:CH63R_06285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06285"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="6"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="509" mass="56721" checksum="776C4B80669F1B5C" modified="2016-11-02" version="1">MAKNQKVVVVGAGPVGSLAALYAAQRGYDVEIYELRADLRDPSTTLLNFTRSINLALSERGINAMRNAGQPKLLEHVFGATIPMRGRMIHGRTPKGDLYEAAQDYDVHGRAIYAVDRAGLNKRMLDILEEMPNVKFFFSHKLTGADFRRCKAWFEVMTSDSATGRAREIEIDFDLMIGADGAHSAVRYHMMKFARMNYKQEYIDTLWCEFQIKPARPPSADAKAPHFRISPNHLHIWPGKNFMFIAIPSDDGSFTCTLFLPSEQTAALENNPSSLPAFFDKHFPGVTNLIPADDLIASFKQNPHLPLISIKCSPYHYDASAVLLGDAAHAMVPFYGQGMNAGLEDVRILFSILDKHCRMSEVNDPAGEADTSAAAVHQRGVALAEYTANRVPDAHSINDLALQNYVEMRASVLSPRYRLRKWLEEAMSVYLPGLGWQTKYSRVSFGNERYSEVVAKSDHQGQVLVKTFEALVCSPLVAGAVYVWWKRPQAVVGVVQGLLRALLRATERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEW7</accession>
    <name>A0A1B7YEW7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159164.1">
        <property type="nucleotide sequence ID" value="XM_018301314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEW7"/>
    <dbReference type="GeneID" id="28865421"/>
    <dbReference type="KEGG" id="chig:CH63R_06339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06339"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="970"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="776"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1065" mass="112814" checksum="4A2287F0DF987608" modified="2016-11-02" version="1">MSGPGLTSNQSDLSRFSDSEPEQDRSPPGKSTADILSGVYRGFKKFAPSRDGESRLTRQPSLSRLGLHSVSPSLTSTPSPPPSSTPTPVPNSSKNRPLQHGRSLSLQSSLAKPLPEPPPSIPSPTGPDVPPAVHYNIGSLGAIEEGPADDIDSRTSTMDSSVSADRSQMYASGSGYNADMASSQSSLASSSRQDGSEDMRENPSLTPRSNGPLSAGPSPSSTQNRTPASAVGTPTASSSSAHLSGLMCNVHRTTGREPHPLVGATTTILGDKLYVFGGRILSRSRPAPLTSDLYELDLIRRHWSKLETTGDIPPPRYFHSMCALGDTKMVCYGGMSPTPNQSAAGPDQQPEVTVMSDIYIYDVPSRKWTYIPTQDPPQGRYAHCACIMPSSATFTSHKAPLSALQHNPSSGNPNEGRIGINIDGTGGAEMVVVGGQDGANHYIEQISVFNLRSLKWTAIEPLDKSCGAYRSVVAPLSPSVTARIGKSSVNGFQRDGGISQEAREPGSSMLIYSNYNFLDVKLELQIRSSDGTLTEKPMSGSYSPPGLRFPNGGVIDTYFVVSGTYLTSSKQEYALWALDLKTLTWSRIDAGGAVFSQGSWNRGVLWNRRNTFVILGNRKRSLVDDYNHRRINFSNVCMVELEAFGFYDNPRKTTPMSGFVSASSPYTGPGLSLARKAGTMAGGRFHSRAAEELGEKALAMRELSDMDILCLHGERIPINSRMVARRWGPYFVQLLREGTATQDGSDAMTLRSGSGVNNPVRNSTLTITPARNTVESSGSMASTIMSSGSSSKAPSTAPTSASAASFSLPASGGGVDASTVNSAPTPRSLPPNSRPRCLYLPHTYLTVQALLHFLYTSSLPPPSSPLCTPPILCSLLQIARPYRIDGLLEAVVERLHALLDSRNAAAVFNATAMAAGGGRGIDGSLNPNFFVPLDATGSPIYPLEGSQNGDSSTDLQGLSSRTAALRINTAMSSGRPSSDELSATTSVSGSEWSSEIGDSERGGLREVWGGELSSVIGLQKRGLRGLMEGRRMRERTGTNSGTGMSGGMSSYGGGQGRVGLGIAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF38</accession>
    <name>A0A1B7YF38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159230.1">
        <property type="nucleotide sequence ID" value="XM_018301380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF38"/>
    <dbReference type="GeneID" id="28865487"/>
    <dbReference type="KEGG" id="chig:CH63R_06405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06405"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="82" mass="8890" checksum="EECB8FC4A94B0850" modified="2016-11-02" version="1">MQGKALRTTRGKVSWVLSLSTFRTLGRGGFGPEGAGMRRPGERWDNSSSRFVSSAACARPATRANDELTGYDTTKPSPRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFC2</accession>
    <name>A0A1B7YFC2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_06190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159015.1">
        <property type="nucleotide sequence ID" value="XM_018301165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFC2"/>
    <dbReference type="GeneID" id="28865272"/>
    <dbReference type="KEGG" id="chig:CH63R_06190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06190"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="29823" checksum="6D020A7D7FDA58D8" modified="2016-11-02" version="1">MAPAPRKRRRAPTNPIETANRKSDEEFIKDHLQSRFVSPSLKARRKAERRIPDWTSWTHPKTDKPYALSLKSSSALAQHELQACFDLVDRTSGADYRASKDGWRPASKMKEMRSPDLRYILVKEAAAAAAVAADADGDDGGKICGFTSLMPTFEEGEAVVYCYEIHLLEELRGTGMGRLLMDHLVRVAESIPIIEKVMLTCFLANAGARAFYERLGFERDAISPVERRLRFGKVFVPDYLIMSRRVRGESERTKPQNGDSEKTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFQ3</accession>
    <name>A0A1B7YFQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159287.1">
        <property type="nucleotide sequence ID" value="XM_018301437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFQ3"/>
    <dbReference type="GeneID" id="28865544"/>
    <dbReference type="KEGG" id="chig:CH63R_06462"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06462"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="99"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="55309" checksum="09D8AC982C4F94CB" modified="2016-11-02" version="1">MMPIENALPPSRRGQKGIRSDMMTDLRKRLEENPYDLEKNPKGIIDLGSAVNDLMLDDLSGWTKRNIKKGQLKSSEYPSHWSHSLLRWTDFCRAPGCKDQQDHPSLPKVAADFMNEHFRVRLPLTSDNILAANGVTTILDSLIYNITNEGDTILIPTPSYGMFAQDVWTRNGVRVVEVPCDDIHEERFWGPPPQDDSPVQTPEVVRRLEVAIEDELSRKGRVGGIVLVNPDNPLGRCYAAHVLLQVSQLCARHKIHLIVDEIYAISAGDRFSSVLSLGLDVNFRNVHVLWGLSKDFGLSDLRVGFLATYNSQVYEAMRALTMFGQVSSFSATVAATLLSDTKYLRNHYLPSFRRRLDKRRKMVEETLDNYEIPHVKPEAGFFVFVDLFKWVELYLQKHGKGGDLAFLEYLMKQRVFLEPGQALFSQRTGWFRLNFGGEKESFKLGLQRLLHCLRLLDGQEHHEPFTQAPELYFPPPKAMAHFLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG50</accession>
    <name>A0A1B7YG50_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159580.1">
        <property type="nucleotide sequence ID" value="XM_018301730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG50"/>
    <dbReference type="GeneID" id="28865837"/>
    <dbReference type="KEGG" id="chig:CH63R_06755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06755"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="455" mass="49361" checksum="17AA091788F60461" modified="2016-11-02" version="1">MHRQQNASAAHQVETRVARRLKEREDSKASSGGGAGGGANSPGRSSSAAAAEEERRWPAVPKPFQVDPELVSLNKFHSTYASAGEVAMFAMLPGLTSAGSQSAVFDEVLRATALASSSLQMQQPGLMARAKQHYRRAIMKIGAALQNPATAQDDSVVVALLTLGIYEALVPDSTPKKITSHCRGSLVLLRYRAEQGVASSLDNGLLTFLIHLGILETFIGLYGRSSVLPVVKNAPWARHCTMEPLLERAMDFKETICKALLSTETWRSSVPHILRTGLDIIRDLEAAANYSITSPGPRKTGADGQGLNNFNGLLSRKSYASEAIVRGLYLTVRLHVLEYILSLSMALGELTREELSMLASLPHGLSALEQVCEQIRVVFGFDGREPASRELGIGFSAWCMFWPMLAVLKSGFADKYTRLWVMDKCATVSRASGFGMAMYQMGWFEQKSCKAGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG94</accession>
    <name>A0A1B7YG94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159519.1">
        <property type="nucleotide sequence ID" value="XM_018301669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG94"/>
    <dbReference type="GeneID" id="28865776"/>
    <dbReference type="KEGG" id="chig:CH63R_06694"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06694"/>
    <dbReference type="OrthoDB" id="5088865at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="309" mass="33595" checksum="90127B5268099566" modified="2016-11-02" version="1">MTIEEQVPEDFNNAHKADFKSIYNQPDPRAYFAALTPLGYQIPQRALPVIDRVLALSSVTHDATTTTTTTDDNVEPGVIKVLDVCCSYGINAALLRLDLDLDGLAAHYASTPKLSAAEQTAADKRFFASRPRRPRVEVLGLDSAPGAVSYAVETGLLTAGFAEDLEVAEPSPALRAALRDVSVVVCTGGVGYVSATTFARAAACVRDAGRRLWVVSFVLRVFPFEGVAARLAEEHGLVTERIEGTVFRQRRFISGEERRAAVEDVRRRGLDEGGLEADGWFWAECWVTRPRGAEARMDDVLGSVGVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGB2</accession>
    <name>A0A1B7YGB2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 82A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159355.1">
        <property type="nucleotide sequence ID" value="XM_018301505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGB2"/>
    <dbReference type="GeneID" id="28865612"/>
    <dbReference type="KEGG" id="chig:CH63R_06530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06530"/>
    <dbReference type="OrthoDB" id="4795434at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="53158" checksum="5218A1CA75A69C08" modified="2016-11-02" version="1">MANLWTLGPLDDIMPDIDNCHVLCFPCPNHHQPRTGAVLRHAYGRLVKETPVLGGFILPCNDGTSRPGTKTLQAPDSKPELEVKNATEEVNLSYQELKALGMPRRYLPPSLVMPSRATSDSGNRRTTAARATFVDGGCFLAFNTSHALMDGTSVINVMAALAKHAADICIAANDDEVLPDANTGPEPGLTPRFGPTTSDLETLNPNVPSSRYDTLKRNPRSWQMLGLDYRPREESSTVLAAKLPPMDPVTRILSISNDGIQRLKDRCSAEAAANDPAQWVSTADSLAAILWTSIVRARTRNPEQNAGEATLSTLMTAMDVRRLLQPPISSTYLGNGVLYTRSESTTQELSGPLSWGSVAQLVRASLREHQKPEVMRETLELAASIPDVSALGLLYPTWLANDIVLSSIYGLGFYELNWGRTFGGQETADFFRFPLGIFDGICFVLPRRRDGSAEIQVTMHKEHMQNLLDDVEFRSFFTDVVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHE8</accession>
    <name>A0A1B7YHE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_03867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160088.1">
        <property type="nucleotide sequence ID" value="XM_018298842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHE8"/>
    <dbReference type="GeneID" id="28862949"/>
    <dbReference type="KEGG" id="chig:CH63R_03867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03867"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="152"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="431"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="570" mass="64680" checksum="213E2E252AAD483D" modified="2016-11-02" version="1">MNDKYTRNAESDSGSDGHGRPAYLINGDTPGPVLTVNEGETLEAFVDNQLAIETTIHWHGIYQINEPWNDGVPGVTQWATEPRDNYTYRFTPQGQYGSYFYHGHFGPAFSDGQRGPLWIIPAEWRPRPYELISKKEHDIRAMRSAEKSPRHIIVADWNDQPMDMYLIRFRDTGYIPTCANSLTLNGRGGTRCESARDIEDAGGPGRNERGCLWRIPGHEYTNVEYCTETRPELEIVQAEPGEEWVWINFIHSGAHHSLAISIDEHEFWVVAADGEFVHPQKVVRTHINLGERTSILVKLDKPPGDYAIRLHSLRFEQMIQGAGILRYATNKALTEHSNRIVPNTKPWLHLNGSVINAADKAMDETKLAPYPHRPPPDKADFTLRFMVNKTGPSTWVLNSAPHEFFRQNVPPIMWNEKSRGRTSWGDSNGFLRNGSVVDLIIENGAQVDSSHPFHKHNHKVWIIAQGDGGFPWRDVNDAVRNGGAKHFNLVDPPFRDGFTLEAGEGKFVVVRYKIYFPAVSMLHCHMIHHFASGQQVILLEGMEVMPPVPQDLKDKPHVEFDFPPRYGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHR4</accession>
    <name>A0A1B7YHR4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn 2cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160136.1">
        <property type="nucleotide sequence ID" value="XM_018298890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHR4"/>
    <dbReference type="GeneID" id="28862997"/>
    <dbReference type="KEGG" id="chig:CH63R_03915"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03915"/>
    <dbReference type="OrthoDB" id="5425448at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="58162" checksum="09CF3CDE751B96F9" modified="2016-11-02" version="1">MSLCGMIIARYPGEPLALFVTAEDILQDISTSFPFLSSFSLHPVIHSVRTDFEIDDYRTRPTKKARFRDDGAQDKTISASKLDSSFTQQALNTLVPGQPPSLHFIMSPGSQLLVRGRRQGPMDPISRNKAKETRDRKMECIRCKLSKQECRRNDDTLNGPCIGCEKHGGSQRWPGPCVKAHFGDLVLSGSCNYISSYAIYHLTLNNDTRIRRELPKRINLDELVGRVDQARRKFNFEVYQGGQPLYVLDLDSCHDYLQGLRNQMDVAEHDFPAFIDIALLQADTSGDDWEKCMTQTTSPPRDWLSLLCDVNRMPSRASFSYVSRPNISEPAAVVERPINVEDPDDADDLILAAQLSRIVCRKLEVKAYHHLQCLLYDWGTMEDGRVLTFLQSLGRILLTLRWRLSWWAAVPSIVVGDGTHGSKSDDANQQRVESRVRSLCWILYFYYCAVRRRLPVSDNEMLAGVYTEYPGAEKVVWDDFPGDESIKGFEAWIERGRELINEAGVLDRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ03</accession>
    <name>A0A1B7YJ03_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160543.1">
        <property type="nucleotide sequence ID" value="XM_018299297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ03"/>
    <dbReference type="GeneID" id="28863404"/>
    <dbReference type="KEGG" id="chig:CH63R_04322"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04322"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601716" evidence="3">
        <location>
            <begin position="22"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="193"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="661" mass="72132" checksum="B0569CD89A4EA63A" modified="2016-11-02" version="1">MSSMRSLLTAALLSVGHLAAAQTIKVDGQEVAADASTVAPAAEIADVSVASTSAGLFDQERVQLTDAVLANLTALQLSNISLFGFEDASSVEKRSLFGRCKTYPGDFLYPIGLVWDIFDLLLGGALTKTIPEASVCYDDFGNYDQAKCDFLTANWVNGSHIHTEDPTAINAVLFEGLNCMPPTINVGETNCKVGGLPSYVVEATTVAHVQLAVNFARNLNLRLVVKNTGHDFGAKSTGAGSLSIWTHNFKKIQYLESYQQDSYSGPVFKLGAGVRAFEVYEAAAQYGVTAVGGEGQTVGVMGGYVQGGGHSPMSGLWGMAADNVLSFEVVTADGRFVTASESQNPDLFWAIRGGGGSTYGVVTSAVVKVYPKIKVTTMTFAFSSGTSITNDQFWAALRAYFDGFVKYAVDNANYGYFRIQNLGTAYAFDMGPWWAPNMTEAQLRELTAPLFAKWAEIGVNVEPVYTEYDNFYDAWSASFPLEPWGSNAIRQASRLFPKANWEDETKLNATFEAIKYVVEDGGYIVAFNMMAAPKTGYPDNAVNPAWREAVMHCITAVFWDPTAEESIIKAASDKLTFDWLQRWRDVSPGAGAYMSESDYIEPNFTQAFWGTKYEKALALKKKYDPNDVFYAQNGVGSEYWEMSEMILGNLPSQNSKLCRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJP1</accession>
    <name>A0A1B7YJP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium influx-promoting protein ehs1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160631.1">
        <property type="nucleotide sequence ID" value="XM_018299385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJP1"/>
    <dbReference type="GeneID" id="28863492"/>
    <dbReference type="KEGG" id="chig:CH63R_04410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04410"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="657" mass="71771" checksum="1D282254C4A1B663" modified="2016-11-02" version="1">MQLSPLQSRLAASLVASLLLILIYYMLSTPTFALAAEVTGAAHPILDHLQFDDSLERRSPLEPTYEPEFAAFDRSIIGRAPPGVTGLANNVKVNRNVPGNTTQNFVFEAIAIFASFFDGTDEAFVVEPREGINDSFSPELVPTEDEDLEDESRGLRRRQAQGRTVYISATTCIQPQRAANNTKEDPPQITMYISTSQDNQTPGPGQNSSLQKTVKFEEGAATFSVNATGDVFIGIGAPEKDGNKFTGDWNFDVAASTDEFFHSFDGNPSELLWVDSDSSAALLTTQNLTDSQNETQIQEIMQQTPPFVMFVENRDHPTTKGVRRSMCGLENYAQIAARKGGKFGNLASTVMTTRGPGNLPKQQFFFNGLNASALYTGILVHTGNSSALKKRQDGGSTGGGGRVFEATLFETKDGVCTAGPVHFVGMADLIPGENCKIITDLQFCNETEYAVPANSNKMNITQLAQFYDNYARDMYANFQKQLAQVACEAPAVQRYSLARNCSDCEIAYKKWLCSVTIPRCEDFTSPTSFSLVRNANQPFPNGTLLPNDLQNNYSARVNQHSRNPLIDEMIEPGPYREILPCAYLCYDLVQSCPASLGFNCPTPNDDIFNSSYAIQEDGLLTCNYPGAVHNPSASPLLSISWGLLSALALGTLSLVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YK84</accession>
    <name>A0A1B7YK84_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160988.1">
        <property type="nucleotide sequence ID" value="XM_018299742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YK84"/>
    <dbReference type="GeneID" id="28863849"/>
    <dbReference type="KEGG" id="chig:CH63R_04767"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04767"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="8">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="500" mass="55577" checksum="FE5785DA006D5995" modified="2016-11-02" version="1">MASDMKATVEPTTKGFSVCGYEKIEYDFEFLDGVFNKQNSQLADCYSRWKRCLAVMDLNIFNLYGEEMKEYFDHYNIDLKIHKTMIGEKAKSMETLLSIVDSMTEFGVYRKEPVLVVGGGLVTDVAGFACAAYRRNTPFIRIPTTVIGLIDASVSIKVAVNYGNYKNRLGAYHAPTHTFLDFKFLRTLPTAQIRNGFAELIKISTCAHLETFDLLDRFCEELIETGFGRCDGASKEVRDAADKINRNGIHEMLKLETPNLHEIMLDRVIAYGHTWSPLHELSPDVPLRHGHAISIDMAYSATLAHVLGKLSSQEHRRLLNLFSRAGLSMDHAQFDEEMLDKATSAILKTRDGKLRAAVPSPLGQCEFLNDVSHKEMCAALKVHKDLMKEYPREGAGLEAYVDASDTGYTINGASVEDESRKFMNGVEKSVTKDDTVSSGVSSNGSSTPDYGLSSGKNLGRDDAKYAAAGFEPKVLESLGNDKVGVTEHNKIRHEVENECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL61</accession>
    <name>A0A1B7YL61_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161294.1">
        <property type="nucleotide sequence ID" value="XM_018300048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28864155"/>
    <dbReference type="KEGG" id="chig:CH63R_05073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05073"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1328" mass="142860" checksum="89BF513FDFBFF940" modified="2016-11-02" version="1">MTSTTSQGDLVARPYTSHSRSFSTPRPSTFDQSSTRSNSVAESPARLKVPDIKITSPATSPGKPSTAGPRYSLTPRQTTFPPPVTQRLAVPAVRPLPPAQQHLPPGSRVQRAQPPLALRLPITASPDDSRKRDGLIDVALPYRPFYLQRRVLSSFAVLFAGLLVTVEAVLDLSNRRGGLGSPEHGFRYLWQYGSAFIFTCIAALWARPEHQAKASAPWLRMAKGPASVDRTLMLDYVFMFEPWTIIKAARNRDWLVAAAATVGLTLKLIIVIAVALVSPTFQIVTARGASLTLHNAFVNDPTGLQNAGALPFFTMAALQTRGLSFPDGTSKQFAFQSFSADLPATAELRTNVDGFESDIECEPALFNLTGVQFIQASDTQLNATVSTPACVMTQTIPSMSLLGSTLPTFFMAFQAGTCGNSSFPDDGRVVVMAGAITIDQTTVPTQSGVFNVPIAGIVTKSAALICRPSYLLTRVHVTKNNTQLIKIERNPSAGNKSLDKVHPWDVVQGHFNSYPADSQILAAMPDVNSWYPGAVTVASDAVMNSVVAMEVHDHGVPPIDTFLKTDNLTQLSTAYWRQYTALVARNSMMGATQEKSTGTAVIIGERLNVRPIPAHLLSGLLGFVLVLVLAAVALAPARGFLPRNPNTIINMAALLGHSRQLLQCLRGTGAAETSTVREKLLGTKYYTGVEPYEKAEKEARGYFKIFGGAPPPQNAPPEFVQSARWRHPLPLNPWARLAAVVTMIGMIVSLEVVLRISNANSGITTIKANTDRHFLWTTGSGVIFGLVVLYLAAADCATRCLAPYAKLKEGGSFETTVDVDFLDKSKPMILYDAVKTRNIAVVFTTTALLVSSLLATFSGALYSTTPIPSTRPVSLKALDSFVNASSPCPTCTTDTLLASLILDANLTFPSFTFEDLNFNSLQLTEQLDMQDGAGTILVTLPAIRSRLDCRLYPQSEINTNFTLPDLPTQQFSQEMKIDIAGEPCLDPSIKSNAVLPPGVSPSSVFGVATPRSATSSQCSDFTYVWGQLADSMPSQVGYISAMGCNETLETVMASVRLTGSSLHVDSTYPPVLQENTARPVTLNLLALQYGLLANLTTGNQLDPFFSSLVTSRFAVPAGSLGDPGLGKSGLVADAIVRQHGILRAQNLNVNSRRRLPNVAAQDIIPAMLESTSVTSLRRLVQDSASTRIIQSVLALLVALTLVAWLLTPGTDLILPRNPCSIASIAALLADGNVFGFLGRGAEWQATEEMKRSFLDGSHSMGFKMGYERVRRRRGAEDLDGTSKGDRDVAYGINVKRGGGWGGGEDVGLGILARVNRAQRGFVRGWGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLD3</accession>
    <name>A0A1B7YLD3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular salicylate hydroxylase/monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161366.1">
        <property type="nucleotide sequence ID" value="XM_018300120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLD3"/>
    <dbReference type="GeneID" id="28864227"/>
    <dbReference type="KEGG" id="chig:CH63R_05145"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05145"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="161"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="446" mass="49297" checksum="18AB30A10026C64C" modified="2016-11-02" version="1">MKIAIVGCGLAGMSTYLALRKFLPGDHHVTIYESRTPPPDQDVKPSENLDTADVAAPQGGCIGIPANGMRTLHNLDPAVHAAIQERGYAYGTVRLRSSTGWDLTVKRRTRRGGDVTMMMARQAAWRTLREAIPDDHVVIRKVAKITKRGQSGNTKPVISFADGSSADFDLVIGADGVHSTVRKHLFSDHSVDVAAVFSKRCGIWGFIPMRIPEEVASTKSVVIVMGDNASMGYSAYRPTEDDSLTWWSLYDTDEPPSRKEVPREFVSAMLQDMYGDWEEENVRGVLQKASAPFIYPVWTVPELPTWGDGGVVLVGDAAHAMTPDIGQGTSQAFEDSEALGMLLGRALQEGGIAQDAAVDLAVRGLYECRLPRLSKIKLLNAQARSKGVRRNIWAQRLVFFCIWITSRFTWLHNLIYSNDREGEEIINGWDGDMETRKVVEKLLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM29</accession>
    <name>A0A1B7YM29_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161618.1">
        <property type="nucleotide sequence ID" value="XM_018296802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM29"/>
    <dbReference type="GeneID" id="28860909"/>
    <dbReference type="KEGG" id="chig:CH63R_01827"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01827"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="8"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="171" mass="18094" checksum="98508F504EAA072C" modified="2016-11-02" version="1">MSDKITSKNLSYDTTIPPFLRALHAQAARNAADPDPILSKRRRAGKKRSESEEAEDAPLVVDDEGNVVDVRVDKDGGVDESALKKDGEVGDETGAGREESRREAEKLAGIGASKKRKAGKVVGGGGGDGGYGDAAEDASNNVKKDSKEDENGKKKAGKKKGKKIKLSFDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNP8</accession>
    <name>A0A1B7YNP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162156.1">
        <property type="nucleotide sequence ID" value="XM_018297340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNP8"/>
    <dbReference type="GeneID" id="28861447"/>
    <dbReference type="KEGG" id="chig:CH63R_02365"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02365"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="291" mass="32148" checksum="D979E88F55B45E58" modified="2016-11-02" version="1">MWVASVDQMMPKRLTSEPAPGSLSQLRLQTKTTSKFETRTAAIHVTPQPNQKFDIKVIKEDAQWLSRNAKVNLITALRATVVEFQSRPASHLTSTLSSQDIVNLQEASGVASMQSSALVPIAGAAQDAETIWADFEKEESRRQRIFQTYLAERRHFLMTAALVQENVLYTQPSASVLTTAGEPSTQTHLIPANDRPKYLDDLLTTYLQYVTDAIGRLAEGLEAVVEDKGLLGEELELEWMRTALTEVVHALTVVFQSIYGNGDSFVPSAVVGQWFGLMDNYGFLNGITAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQD2</accession>
    <name>A0A1B7YQD2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162773.1">
        <property type="nucleotide sequence ID" value="XM_018297957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQD2"/>
    <dbReference type="GeneID" id="28862064"/>
    <dbReference type="KEGG" id="chig:CH63R_02982"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02982"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="260" mass="27838" checksum="A5A759C4E1B54590" modified="2016-11-02" version="1">MASVKRDETTPFLLQVFYKTGSFHRTDEFASRSLPPALSLYTWSDCTLTELAGQIVANDPSLLPSPSVGSRLAFRLIYPDTRHTAAPSSTHHTQIPAPRFMVKDLGSVVLGEGAAGAILAAAAAAGEEGPGDIRMADGTATVGDDTAKDKTLGDAKFVVGDYISCAILPPLPDGSVAPALTARNDRTAVPFSARGGLGGLAPQGPRRDAAFGGRQARDRDRRRPGFGDDAFPEGEWRRGERLPEDPPDRSWGRGRRQDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQF6</accession>
    <name>A0A1B7YQF6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps9 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162760.1">
        <property type="nucleotide sequence ID" value="XM_018297944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQF6"/>
    <dbReference type="GeneID" id="28862051"/>
    <dbReference type="KEGG" id="chig:CH63R_02969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02969"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="245"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="769" mass="82835" checksum="F0DF3F6FDA822C76" modified="2016-11-02" version="1">MSSTGPSRSPAARPSTIRAPSFTRQSEDSDPLRVPKRAQTFHNGTTTDPLAAAPATPGKPTLANEPEAPDAFETAGRPSTDNDDGFDGRGSVDLGELPIELVSLTDSFVESLTTKTYPTPLTLDKVSELFQDFYQVASTHVNTHVSSLISRHNRDASPAPSASSKVSTASRLRAKAASLGNKDKPKVLPRPEPEQQMITAEELANKKKARKAIEAKRGIIEEAVERRLCEGIYHKIYRHKSTQDEAQDSKLRSKTAALALVGIGPADLGIDLGEDASQTPEAAAEKAEEIRKSLEQARKDLILMNEKRYPLGKVHHLKAAHKSIVETLAQFHPSASADEIMPMLIFTLITLPPEHLNVISDLHFIQHFRWEPKLTGEAAYCLTNLEAAISFLETVDLSTLRADELPQGPARDPSQPGTPRADTFPPAFPPGLTVTADSTVESDPDNATPTRPLPSSSASSGLRAAVQARNRRLSELVNTPAQAIGAASDAVLNTADQHLKTISTSLGDSYKFLVGKLRETQGTPTESGQGLVVPKTLDDARKLMSTPPPDEEGSVSGASSVHGTEEAESTRRPPVREDKVLNLIGGRKPSRDHSADSSRSVNSSKKVLFAKEGEKDLATPSVAPVTNPLDSVRNFGNSFSRFSGMNMIRGLSRTASTPIPAKEAPKDIPREGASKDVAAKVADGGDLASVRYLGERPERLVTNVARQAFPDIAAALPPKQTPKINPPNKRFMELQNPGDLKLGEVLDLLRDYRRLANALKDMGAFDGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQP0</accession>
    <name>A0A1B7YQP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162791.1">
        <property type="nucleotide sequence ID" value="XM_018297975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQP0"/>
    <dbReference type="GeneID" id="28862082"/>
    <dbReference type="KEGG" id="chig:CH63R_03000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03000"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="290" mass="33457" checksum="6A040DA926C29E4B" modified="2016-11-02" version="1">MDPINPSDYSSIPFGYAIVKAVGRRNKPEKSPVFFIVNCMIVGDASLRLRRMLTQRPNTQHWILLHPARDVQEVMYIIHHGRRSPDLAPATADAMLSVCYTADRLDLLEGISKVWGATLYVDEKMTSQQLWNVAVAAVLCKNNAVFFAATRKLTWLHHARYRELVTNCNFWELFLAANLEQLRNLLWVDMSEIYFETNHDCHVESIPGIQPSDLEALPTLMSRFAYLRERCDVEMIDREGESYRMVVAEQASQTWPYRLREEVSGALMDVHKKSGLHLAQFYHFLDLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRQ5</accession>
    <name>A0A1B7YRQ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163246.1">
        <property type="nucleotide sequence ID" value="XM_018298430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRQ5"/>
    <dbReference type="GeneID" id="28862537"/>
    <dbReference type="KEGG" id="chig:CH63R_03455"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03455"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="382" mass="41970" checksum="ED5EA3730A862370" modified="2016-11-02" version="1">MTNIPCCPIPTVQHTIAGEYGYLDTMYHLCEIISRRLNPDVATSVSYEQMVENCEAVENLRNMVAPNIRIKEQCKRAVDRLQHYAVRLHTSFVISVCCRPALRRDCTKLTPEQKRHLSEKCQHNLAETVRMFLAMHQLSVIPTRSWAFTYHGLSSALLLGILGETKNSPEVRQLQGDLIAALSATAAKEATSPSAHIPKTDKDIELSGPLWRALTALRNIYEHGTIMGTSQLKGTDSSGTGSGARTPLPPMLMGPMANNVNGGADGGGVGKGFGLDPHQDAALAMAEMQNGTTLAAEYTPKYGLVPPSPDSQSLIMRPSMGYPPVSMDNIANLDPSTYMSPMDLYESIWWESPDPWNTGVDTMNFDFVAQPPPGQPQQQYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSW0</accession>
    <name>A0A1B7YSW0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163638.1">
        <property type="nucleotide sequence ID" value="XM_018295276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSW0"/>
    <dbReference type="GeneID" id="28859383"/>
    <dbReference type="KEGG" id="chig:CH63R_00301"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00301"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="155" mass="17351" checksum="2AD9CD6393F37AF7" modified="2016-11-02" version="1">MYLKTKRVHRWSGIQDPVHGSLFVVLASGRDIAHKAFESPAYAEPCIVPIAKGIFGGYISQNAVKKIADDFYLVTAFFKLVNVPPSVYVPYTKVWRGRRVADATNIAKGAVPNCIVDHWVFYMMESLTCTDAVVKELLRLRPPVIFVSTVVWVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT05</accession>
    <name>A0A1B7YT05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163688.1">
        <property type="nucleotide sequence ID" value="XM_018295326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT05"/>
    <dbReference type="GeneID" id="28859433"/>
    <dbReference type="KEGG" id="chig:CH63R_00351"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00351"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="25018" checksum="781E21D29B0D2A2C" modified="2016-11-02" version="1">MPNTGKPSPNCHLCRQRRVKRLDKCDLARPQCQRCIKYGVLCPGYRDDQDLLFQHTDAAAYERRRRKCQQQNLPLSATDTLEVITFTSVSSPSSASSWESDNSAFRSVGTPPLPLLRPVRQHWTAESVPLVIGLYSGLDFLPGLFRGVGQDHCLRLAAHVFTRAYVINRFRPQTDYRELSMFLGNALASVQNAIMSPSTCTSDSTIIAVWLLGNYEASLAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT91</accession>
    <name>A0A1B7YT91_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163625.1">
        <property type="nucleotide sequence ID" value="XM_018295263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT91"/>
    <dbReference type="GeneID" id="28859370"/>
    <dbReference type="KEGG" id="chig:CH63R_00288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00288"/>
    <dbReference type="OrthoDB" id="4844626at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="268"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124942" checksum="42B7EB06388DF7E0" modified="2016-11-02" version="1">MNPSSQANAGFQRAATKFKQSIPKTLWDQFAYDSNSLSSLNAEIKAIQKSHGEKGSLRNMARLGNFIEAMTQFGKVIEVFVNASEFVCFVWGPMKFLLGIGSAIPGHLLYKDMFSEHQNLKVILEDYYSDVLQFHAEALKVFGRSKFKDLFHATWKTFDSRFGPILQSLQSRRELLESEKLSASLDHIHNVRQRIDNLYQDQIRAVDDKVREKHRSRMTLIKEKLRAPEYYLDQEVAAGKREGLNTGRWLFEESQYTSWSDHTVSAHSILYLNGIPGAGKTTLVSSIISRLLEIQSSNPSLPHSVAYFYFKHGNSEKNNHDSFLRAVLTQLISQDTATSQEFFQKLSSQADVNIRSRESLQTLTKSALEEYRVSFLVLDGLDECDREQAEVTVKWLLSLLNDDRYIHKSSLRILFSGQRDGLLDVLLCAYPTICLESSEHTADIEKYCFQHFVFGFDKITRYERITASIYESEHESERETAQKIIALVVTAKRDLKWREIQSFFCIDSSNGTVDPDERLQVKAKDLCGSLVDVHPINGQASEHEYAVRIVHDTARRYLINKKIVNDALENARILSFCMEYLTSGPFSRINRSHTVAAHARRAYYSLQDYAVAHWYDHATELAAIRMYDSEHCPEMWEESMRAASLLARFLVDYGSSVDGIGGGDTSVSLQATLDKLPSYERDRVSLLNIVQRTTWIRQEIENLENLADDEKQILAELHGSNVGYKCHKPWCLMFATGFDKSDERESHMNRHERPFLCPFHGCFGSIVGFESKVVMDQHHKKNHSDAPPTIPRFPTPRRTRTSLDLFRAASRGDIDEVTQLLDNGHDANRTKATLFKTPLWISAKNGSYEVCKLLIERGAHLNQPHVRGYQIHNLPLATASEGGHVSTVHLLLKAHEKKKHTLYTSGFLTALQGAIQRNHLELFELLLSFYRLINFKDTWVSRRKVLLEACGCAQVSMVKLLLQNGFQSEADYSCIDACLSKMKDEPEVSDWAVQILEALLSTGQPEITNMDSWLISEGHQAIVFMILSYPKTRLGRLSLIDLLDLATKKSSANIVDLLNNLLAEAIAADENEIIPDYIQATARLSANASRSLESETSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU47</accession>
    <name>A0A1B7YU47_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibroin-3 related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164093.1">
        <property type="nucleotide sequence ID" value="XM_018295731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU47"/>
    <dbReference type="GeneID" id="28859838"/>
    <dbReference type="KEGG" id="chig:CH63R_00756"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00756"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="532" mass="56486" checksum="A11790B170180B6C" modified="2016-11-02" version="1">MPTIDVAMARSLRGGVWGSVASSIAANIETRGITDTVNNAGNQINDVKTALSSWDNCMAVTYCKWPVIGVMIFGGLIIFSIVWCIIRCACCGLSCCCQCCYCLKCCGNCCGCCDTPKGTPHKHLDDDPYGPPTNQGYKSQAPMAPFYNTAPTHVAHSTAPAPTASGAAAPPQYAEFEVSKSGANPADADALPAMPSWEGAGSKKVALTEEVELEQMKPATSPNSNAQNMPLMAPNAMSHPNSPMPGDRSPYGQNAQAGSSGYFANANQPANPYTTGVQGPGGYNDGAYGQSTSPFGVDQAYGTGAMAAGGMAMAQGRRTPHRELNNNNGYGPQRGQTYPPPQQEFDQGYGDYEQGGYGMGRPPRAGPSPAPVPRSFTAPPRNGPSPAPPGFRRSPGPQNDYRGPSAPPADYRRSPAPQNDYGYDQQDQYLNDNYGRPQYGGGARQYSSESTRPLAPQPSYIAELPSPDLRNNGGFDFSGNSRPQQYNYNRSPSGGVQQHIEEEEEQRPPQSSGGTYPGYKAYQPTKDGWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU94</accession>
    <name>A0A1B7YU94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecQ family ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164110.1">
        <property type="nucleotide sequence ID" value="XM_018295748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU94"/>
    <dbReference type="GeneID" id="28859855"/>
    <dbReference type="KEGG" id="chig:CH63R_00773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00773"/>
    <dbReference type="OrthoDB" id="4851002at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="17519" checksum="7F8D5254FDCB3780" modified="2016-11-02" version="1">MWSYFVFEIFRNCPSQTQRRQYLVIGSKSISITHLRILSSSKDQRTKIGDLNRLTDLNKQLTGKKRPGQHQHQPQQQQELCQTAGSKQEWANIGSETKRAIADYQADQAAGKSPGYTKIGGVVETAFSAYNGGGDDSIRIGKKGGLADIGKEISAGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUU2</accession>
    <name>A0A1B7YUU2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164332.1">
        <property type="nucleotide sequence ID" value="XM_018295970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUU2"/>
    <dbReference type="GeneID" id="28860077"/>
    <dbReference type="KEGG" id="chig:CH63R_00995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00995"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="101" mass="10943" checksum="E34EDD1D5DCDB3A8" modified="2016-11-02" version="1">MAQVEIWIPPPRNVGDVGHVLANRCLSDLRIFIVVSLFTFLAPSQGAARSSSALEKSLAGRHPLLGIQAIAPPSRHGVDAAYYPLNDRNSFLPKVRGRPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YV55</accession>
    <name>A0A1B7YV55_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_01083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164420.1">
        <property type="nucleotide sequence ID" value="XM_018296058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YV55"/>
    <dbReference type="GeneID" id="28860165"/>
    <dbReference type="KEGG" id="chig:CH63R_01083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01083"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="58585" checksum="E8CA163261130D7E" modified="2016-11-02" version="1">MAQAIKSALPTHLKSPLGGQGKSDEEFSSRHHGKTRSHMAFENTSTSVAAAQMRNALTQLSETVSDPEQKKLFETEMDNFFALFRRYLNDKAKGNAVDWDRIAPPAQGQVVDYEDLANSESVQFLNKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYDVNVPFILMNSFNTDEDTASIIKKYEGHNVDILTFNQSRYPRILKDSLLPVPKKYDSSINDWYPPGHGDVFESLYNSGILDKLIERGIEVVFLSNVDNLGAVVDLRILQHMVETESEYIMELTNKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWLNLKAIKRVVENDELEMEIIPNGKTIPGDKKGESDISIIQLETAVGAAIRHFKNAHGVNVPRRRFLPVKTCSDLMLVKSDLYTVKHGQLQMSSSRFGDAPLIKLGSDFKKVSDFQKHIPSIPKIIELDHLTITGAVNLGRGVTLKGTVIIVATEGSTIDVPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWE3</accession>
    <name>A0A1B7YWE3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164888.1">
        <property type="nucleotide sequence ID" value="XM_018296526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWE3"/>
    <dbReference type="GeneID" id="28860633"/>
    <dbReference type="KEGG" id="chig:CH63R_01551"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01551"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="77" mass="8975" checksum="5AAFB49C8C099345" modified="2016-11-02" version="1">MPPSRLVPSILPWCYNDPDPVAKELDKKFGANQYRLSSFANAPKKVKGNQYLVEAPRKLQPGEIRQIHDNVKWHYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWJ3</accession>
    <name>A0A1B7YWJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164910.1">
        <property type="nucleotide sequence ID" value="XM_018296548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWJ3"/>
    <dbReference type="GeneID" id="28860655"/>
    <dbReference type="KEGG" id="chig:CH63R_01573"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01573"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="359" mass="40306" checksum="67C9F7B2F98CDF75" modified="2016-11-02" version="1">MAAVRKHDGYESLSIPDRVDVVLTLIEASRVPGIEWKRYAVEQAKAAMCGRQDDYVQACIAQREALLQRLAGDGMPLTLPPFSHQERRGGPVNERKNAAIGLTVHQRALDCFQNEELSSALDVLDEWQPTGYSSPAEDVVLFRMNVLRGKILRFQGKFQEALGCLDKSRCAAEQQGDVHFDEDAGDLVVETADTMRELDEPVGAEQLLRTQLERPLHTPETRALLNLALTESLFAQQRFTEADQLCRDAESCRLFKMARLRLCITAAKLRHASSDWEGAFSWWTQALVAINKFPPTSGHTTRLIYLSLCDVLKHQGQEELEQASRAQVVKLESLSGNAQAKHWIAGLRHWQAYLKSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWM6</accession>
    <name>A0A1B7YWM6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164960.1">
        <property type="nucleotide sequence ID" value="XM_018296598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWM6"/>
    <dbReference type="GeneID" id="28860705"/>
    <dbReference type="KEGG" id="chig:CH63R_01623"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01623"/>
    <dbReference type="OrthoDB" id="4840406at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601985" evidence="1">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="154" mass="16618" checksum="D66F08EF22557117" modified="2016-11-02" version="1">MAIYHFLTLVLAAAAAATPTSSSPIASPEVAEWQDIVSVEAYGAQMASIGEAGLQALAAERICDLTLCSGVDFTGECSLWCYYENMHQKIPSEKRSSTMSARYGRAKECWFYGAPTCDMHFLMNGPMQRLVNPGGNLQDNVRGQAGCVLCPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UV59</accession>
    <name>H1UV59_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04371</name>
        <name evidence="6" type="ORF">CH63R_09459</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Will I."/>
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                <person name="Zeng Q."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">IMI 349063</strain>
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    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">IMI 349063</strain>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
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        <property type="term" value="C:late endosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Man-6-P_rcpt"/>
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        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50911">
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497550" evidence="11">
        <location>
            <begin position="21"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="42"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="37787" checksum="74B31E75DE5FC1C4" modified="2012-03-21" version="1">MHLPHSSTLLLLLAAATARAADTSTPSTTTSPPACTAASKSGTGAFYDLRPDIAVKTEEGKSSKGSVTTDYHARGWDYGRNFTLNICAPVLEALDDVEGLTKSEAKNVSAYYTYKGETYSIGSSSMDIQSRGRILVLQYKNGSPCDKSKSKRSKAHDGASYNKYVDDDETTALSSFGKSEKKVSAQKDGSDSTPRRKSATISFHCDTEQVGGAAHISFVGSDPDDCAYFFEARSQHACPRAEPHQPGSVGPGSVFAIIFVIAVLVYFGGGVFYQRTVAHARGWRQLPNYSLWAGIWSFVSDIFVIATSSCAQLLPGRRGYSHLSGSPSRRNREDENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0J1</accession>
    <name>H1V0J1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05875</name>
        <name evidence="2" type="ORF">CH63R_02285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000878">
        <property type="protein sequence ID" value="CCF33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162076.1">
        <property type="nucleotide sequence ID" value="XM_018297260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0J1"/>
    <dbReference type="STRING" id="759273.H1V0J1"/>
    <dbReference type="GeneID" id="28861367"/>
    <dbReference type="KEGG" id="chig:CH63R_02285"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02285"/>
    <dbReference type="eggNOG" id="ENOG502SQR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_1_0_1"/>
    <dbReference type="OrthoDB" id="10251855at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="204" mass="22763" checksum="50063EEE13ABABCF" modified="2012-03-21" version="1">MNRYVEVSLSWLLQSSRGHEAKCFHKSPAFASHADQIITVTSPDCGPSPATLGPEYITEGGGRIPALSWTAPLDIESRVKEWLIVVEDPDAPLPTPICHGVYGGIAPETKQVNPRDFEIEDESRSLLRGGFYWGKGRREGVYTPPRPLLNHGTHRYLFQVVALSEPLDRKMLESRATREQAAEAVKDKVLGWGVWIGACERKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0S4</accession>
    <name>H1V0S4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_05934</name>
        <name evidence="9" type="ORF">CH63R_02606</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000907">
        <property type="protein sequence ID" value="CCF33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162397.1">
        <property type="nucleotide sequence ID" value="XM_018297581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0S4"/>
    <dbReference type="STRING" id="759273.H1V0S4"/>
    <dbReference type="GeneID" id="28861688"/>
    <dbReference type="KEGG" id="chig:CH63R_02606"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02606"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_1_0_1"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="245" mass="28534" checksum="24BAEA6CDFDF0E12" modified="2012-03-21" version="1">MDQMMGDGGRFPLETWFWEMPICTRWWTTATVLTSALVQCQMVTPFQLFYSFRAVFAKSQYWRLLTTFLYFGPFSLDLLFHVYFLQRYARLLEESSGRSPAHFSWLLIYSMTSLLLLSPLVSMPFLGHPLSSTLVYIWSRRNPDTRLSFLGLLVFTAPYLPWVLMAFSLVLHGSIPKDEIMGVVIGHIWYFFSDVYPPLHNGSRPFDPPNWWRRLFERRPTEETLDGINNDIVVAGGPELAPDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1C6</accession>
    <name>H1V1C6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_06104</name>
        <name evidence="16" type="ORF">CH63R_07231</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000983">
        <property type="protein sequence ID" value="CCF34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156984.1">
        <property type="nucleotide sequence ID" value="XM_018302206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1C6"/>
    <dbReference type="STRING" id="759273.H1V1C6"/>
    <dbReference type="GeneID" id="28866313"/>
    <dbReference type="KEGG" id="chig:CH63R_07231"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07231"/>
    <dbReference type="eggNOG" id="KOG2103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005034_0_1_1"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497556" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="17"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="16"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="734"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="970" mass="105144" checksum="B9561F3C35D9FA30" modified="2012-03-21" version="1">MRLTTLLLAASSLVGAVFIDEVGDVDYHHELLGVPQVETTLFHKPRRDDKASLLYTLSDVGVLGAVNPSNGAVVWRQFLTGDITYGGGHLRAAEGEDWVVSAYGNSVHAWNALSGRNAWWIDFAGEIRDLEVMELTENGRKDVLALFEEKDGSTVLRRINGGDGSVVWEFKDGSNTTPLQVSNNIEKIFVVSLYGADGMWAVRVSVHDTLTGKRIDDISLGSKGDVTDKKDVMFVGANSASPIVAWLDSDHTKLKVNVLGTKSKQEFALPFPRTLDVAIHAPHHLNAEPHFLVHSRSADSHKGEVYHVNIKNNAVTKHHELPVLPGLGAFSTSSDGANVWFTRITTDEVSLTASSSHAVLGKWAFKEGSESITAFHAVSEVIKKAADNFAVRCAAVTTLDDWVLVRNGEQAWIRPEGLTGGVAAAFAEIPESADLAKTLEAEAHDNVLSAYIHRVKRHFDDLAYLPDYLASIPQRLISSITGAELFSKTEGLARDAFGFNKIVILVTRRGKLFGVDIGKHGKVIWKLHAAQIPSWDAWDVQGIFVEDAKSQVTVRGYFGEYVIATTDTGKLVDSMPQGSWVQTQSAVVVDSASGPWLAPVGYGGAIGDVPAEWAPTQTVVVRGLKGELKGLTYIIEDGTGKEQVAWEFTPPAGYEIVNVATRNVHDPIASIGRVLGDRTVKYKYLNPNTIVVSAYNAAKLTLNVYLVDSVSGLVLHSATHEGIDGNKNIECTLAENWFVCTFFGEYALKDDAGQPLSGQTLKGNQIVVSDLYESDYVDDRGPLGDAANFSSTEPVDTPTGAPLPSVISQAFILSAPLAALAVTQTRQGITSRHVLGYLPESHAIVGLPRQLLEPRRPVGRDPTPAEMETEGLIKYHPALEIDPRQVISHQRDVIGVKKIITSPTIVESTSLIFAYGVDVFGSRVAPSFTFDILGKGFNKISLISTVLALTVGVAVLGPFVRKKQTNMRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1L8</accession>
    <name>H1V1L8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_06178</name>
        <name evidence="5" type="ORF">CH63R_07512</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001020">
        <property type="protein sequence ID" value="CCF34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157265.1">
        <property type="nucleotide sequence ID" value="XM_018302487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1L8"/>
    <dbReference type="STRING" id="759273.H1V1L8"/>
    <dbReference type="GeneID" id="28866594"/>
    <dbReference type="KEGG" id="chig:CH63R_07512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07512"/>
    <dbReference type="eggNOG" id="ENOG502S8N8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041953_0_0_1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="362" mass="40563" checksum="D9BA0B2449A6E3CD" modified="2012-03-21" version="1">MGSGLPTPPLEDQKSRKSSSSSKSIKPNRHTAKRASPHNATQHHDHASQGMSADGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGLVCTAGVRKKTEYKQLPRGYAEVLEHTQFALIATVHKLYSMVRNQQQWDLGEPELNDRGQPVIHNIAQKLGCIRPNSDIDLPVHSVFPEDEAGLTELARQLEEQQKERDVENAMKIEVDSTSSCERSDRASSSEIDHSEFEADYRKAVFGGHNNPMTMSPQSFSTGYTEFDVDSVASPVDPAAVMFQQQNQSPPMNAYQQWSMPRQSAPPSMDLTQQFFQHPGALTNMDMLNQGLIESEFGTIKPHVLNCPNPEVMMGMGDPMIYGGYDGEPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1U2</accession>
    <name>H1V1U2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_06238</name>
        <name evidence="17" type="ORF">CH63R_13339</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CACQ02001050">
        <property type="protein sequence ID" value="CCF34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152730.1">
        <property type="nucleotide sequence ID" value="XM_018308313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1U2"/>
    <dbReference type="STRING" id="759273.H1V1U2"/>
    <dbReference type="GeneID" id="28872420"/>
    <dbReference type="KEGG" id="chig:CH63R_13339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13339"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_0_1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
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        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_BS"/>
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        <property type="entry name" value="Mn/Fe_SOD_C"/>
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        <property type="entry name" value="Mn/Fe_SOD_N"/>
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        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR04212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="208" mass="22867" checksum="BF8AF1712134CF3A" modified="2012-03-21" version="1">MAASPYTLPKLPYAYDALEPHISAQIMELHHSKHHQAYVTNLNKAIETYNANPLQNRIAVLATLNFNGGGHINHSLFWENLAPASSPDASPSAAPALTAEITRVWGGLDQFKQAFNAALLGITGSGWGWLVKDDVTGLSIVTTKDQDPVTKGVPVFGVDMWEHAYYLQYLNGKVAYVDNIWNVINWKTAESRFSGSREDAFKALKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1W1</accession>
    <name>H1V1W1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_01099</name>
        <name evidence="15" type="ORF">CH63R_06228</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02001057">
        <property type="protein sequence ID" value="CCF34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159053.1">
        <property type="nucleotide sequence ID" value="XM_018301203.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V1W1"/>
    <dbReference type="STRING" id="759273.H1V1W1"/>
    <dbReference type="GeneID" id="28865310"/>
    <dbReference type="KEGG" id="chig:CH63R_06228"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06228"/>
    <dbReference type="eggNOG" id="KOG0556">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_004553_2_1_1"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="245"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="563" mass="61958" checksum="52FAFE944B7FF185" modified="2012-03-21" version="1">MEDASAPTSKKGAKKAEAKAKKEALKAQRAAELAAAAAANLNLEDDPAKDNYGNSQTTTPPFSKDAEEVEIRSLDESYNGKTVIVRAWLQNSRVQSAKMGFVELRKGGNWNIQGVVLASEEEPIVSRRMVKWITSINPESFVAVEAKVKQPLEPVKSCRVSGLELHITKCFVLAPAPTMLGMTLGAASQPIVNFSDEKAQAGDVDAEKAAKPAAETTTPAASMLTHLDNIAMHKRAPVQQAIADIRIQVKRIFRSYLEDRGFKEFEPPCLIGAASEGGGNVFRLAYFGEEAFLAQSPQFYKQFEIAGGRERVFSIGPVFRAENSNTPRHMTEFTGLDVEMEIKHSYTEVLTTLEGVLLSIFRGIQERCADEIETVRSVYHSEPLLLPEPGKEVRLTFAEAQKLLREEGPAEFANVRDDEDMSTPQEKALGEVVRLKYKTDFYVIDKFPETARPFYAKVDDAGTTVGDGVRVTNAFDFFIRGQEVLSGGQRIHDPAELEDRIRAKGVDPESGGIKEYLTTFRQVGVPPHGGGGIGLDRVVAWFLALPSVHLAAYYPRTPKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2N3</accession>
    <name>H1V2N3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_06467</name>
        <name evidence="16" type="ORF">CH63R_05956</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001160">
        <property type="protein sequence ID" value="CCF34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000004">
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3H8</accession>
    <name>H1V3H8_COLHI</name>
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        <submittedName>
            <fullName evidence="5">Tetratricopeptide</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_06700</name>
        <name evidence="6" type="ORF">CH63R_02269</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001269">
        <property type="protein sequence ID" value="CCF34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162060.1">
        <property type="nucleotide sequence ID" value="XM_018297244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3H8"/>
    <dbReference type="STRING" id="759273.H1V3H8"/>
    <dbReference type="GeneID" id="28861351"/>
    <dbReference type="KEGG" id="chig:CH63R_02269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02269"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="673"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="775"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="831" mass="92518" checksum="296B34AEFFD773F5" modified="2012-03-21" version="1">MAPTSAAITGLLRQVVYYHVDNNAYESALFFAERLSAQDPKSSESAHLLSLCHLRLGDHRTAFEVSRPSASRGSNLGAAWVFAHACMKMERYKDGINALEKAREKWAGKMNLGKHTTSTRSLYPDEAAVLCLLGKLYRAFDDKRRAIECFENAVRVNPFMWDAFQALCDMGVKLRVPNIFQVTDPLVHSFESEVATPSYESKDGTANSFEPKRPSVRPPMDSSDPFNLHRSSTYQDMPYSANMFSAEAEENDFMSKITAARSRLAPPATSNGDLDLLETPTGPVSMPEVPTVRSTLGVAEPPQAPPRRTRTAQAVDPGFLEAPPKMSYKLGGAKRSTRSQDKEQQQSVELHSDTGTGTGALRSTVAPTERKRTVSGHPVSRQLSEEASAPTQRRSARLNMFNKPSIMKSNSGAATIGATAGRELKKARPQISRIMRPGSSGSSVGRVVSGNRKPVEDNGMDVDHAESARVRDSHAVQHAAPKGAPPEPDHARIEEALRWVMELMKKFASGYYSFKAFRCQEALQTYASLPRSQQDTPWVLAQMGRAHHEQAAYQDAEKYFRKLRVLAPTRMEDMEIYSTILWHLKRETDLSFLAHELVDADWTSPQAWCALGNAWSLAREHELALRCFKRATQLNPKFAYAFTLQGHEHVANEEYEKALGAFRKAVAADRRHYNAYYGIGQVFEKLGNHEKAYVHFHTASDINPNNAILICRIGVILEGQKQMMAALQFYSKATDLAPRATVVRYKKARALMSLGKIDLAEKELLILKDTAPNEAMVHFLLGKLYRNINEKQMAVRAFSNALALDPKASQSIKDAIESLEDDMGIEDSMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3M8</accession>
    <name>H1V3M8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Killer toxin Kp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_01209</name>
        <name evidence="4" type="ORF">CH63R_10824</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001290">
        <property type="protein sequence ID" value="CCF34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155222.1">
        <property type="nucleotide sequence ID" value="XM_018305798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3M8"/>
    <dbReference type="SMR" id="H1V3M8"/>
    <dbReference type="GeneID" id="28869905"/>
    <dbReference type="KEGG" id="chig:CH63R_10824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10824"/>
    <dbReference type="eggNOG" id="ENOG502SU2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123452_0_0_1"/>
    <dbReference type="OrthoDB" id="4177994at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55221">
        <property type="entry name" value="Yeast killer toxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554829" description="Killer toxin Kp4 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="135" mass="14474" checksum="57436E5A975A3F43" modified="2012-03-21" version="1">MQFSLTAALSLLAVASTAAAKGINCEGSSNCNPSFNSGVWRAEAGELKNLIDRIPDDKWFNNGQKIACVRWICAFLQNTGGAPGRNIKGLAHFIPDHGCTICGSVPYFYPGINDVSQGMLTFNWVNTPKCEGLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V419</accession>
    <name>H1V419_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00007</name>
        <name evidence="4" type="ORF">CH63R_11086</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001347">
        <property type="protein sequence ID" value="CCF34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Amino_oxidase"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
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    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
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        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
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        <property type="entry name" value="Amino_oxidase"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554854" evidence="1">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04383.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="463" mass="50107" checksum="7D84951A41081BCF" modified="2012-03-21" version="1">MRSQLLSLCALGASLISATPVDLGCYDESAFKPEDIIHRDVLIVGGGATGTYAAVRLRDQNKTVAVVERAERLGGHVNTFRDPATGAPIDYGVQAYIQNNETTQFFERFGVQLNTSALSPFPSTVVDFKTGFVVPNASVVDPNTLVGPLANYLFATLNFDFLAQGAYDIPENVPEDLLLPFGQFVEKYNLTEVVQVVWIFAHGVGNLLETPTLYVLQNFGQPHLLGLSAGYLYAPGGNQQVYDKAGAFLGDDVLYSSVVVASKRTDEGVTAVVASATGRKLIKANKLLLTIPPTVENLAPFDLDASETSVFEQWQDVPYYVGVVSKTGLPDQTNFLNVDVTAAAALPQKPFVWRLETVGVPGYQTVKVIGEPDSSKAQGLVVDAVRKVGVSVGAYAGGADFSAWEQHKNLQLHVSPEAVKAGFYRNLYALQGKRSTYYTGNAWCSDYSPLLWAFTETRILPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5C6</accession>
    <name>H1V5C6_COLHI</name>
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        <submittedName>
            <fullName evidence="11">LSM domain-containing protein</fullName>
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    <gene>
        <name evidence="11" type="ORF">CH063_07220</name>
        <name evidence="12" type="ORF">CH63R_10003</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001534">
        <property type="protein sequence ID" value="CCF35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154401.1">
        <property type="nucleotide sequence ID" value="XM_018304977.1"/>
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    <dbReference type="GeneID" id="28869084"/>
    <dbReference type="KEGG" id="chig:CH63R_10003"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10003"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="274944at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Lsm7"/>
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    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
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    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
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        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
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            <end position="131"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="47"/>
            <end position="59"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CCF35428.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR05883.1"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1V654</accession>
    <name>H1V654_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01359</name>
        <name evidence="7" type="ORF">CH63R_02713</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001657">
        <property type="protein sequence ID" value="CCF35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162504.1">
        <property type="nucleotide sequence ID" value="XM_018297688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V654"/>
    <dbReference type="STRING" id="759273.H1V654"/>
    <dbReference type="GeneID" id="28861795"/>
    <dbReference type="KEGG" id="chig:CH63R_02713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02713"/>
    <dbReference type="eggNOG" id="ENOG502RYTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010170_1_0_1"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="223"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="719" mass="78080" checksum="A5E1BFFE894C89B2" modified="2012-03-21" version="1">MAAADREFDIRSRHSTASGPDEETSLIQSTRMLQDPTGRLLYVGDSASLAYLQLIRMIVEASVGPSDFTMDPSRHKIMEATIVMPANVRPPHILPDRDTANALVESFFTNTHGLIEVFNRAAFEKSVEACYSDPLAAQSSFLCLLYLTFALGTVLGTPRPGSKEDAIFKKLRASEYDRAELFFRSAKALGDPITGFEDADFWSVQALSLMAVYMLAVSKRNAAYAYFGMAVRSGFALGLHRVQENHFIFKSHEIRLRRNLWRSLFVLDRFLAASLGRPVAIDEEECSADALLVFEKNSQGELVRVTNPNDGLDAAVRSCRIIGQILKKIYARRRISVRLAQEIWEQCSSWYSTLSPDLAGRQVAADSNNPIQSIAALHVNLLYCHSIMLLTRPFFICLLSKVHGERSGLHLPVPRWINRMSKYCEACLHASNQTVILVQKAFESNYLPQRNPFVLYFLFAASLIILSNEFAAIYPNPSYGISISNTIAIMRYCAASDPQANRLLFILTSFRNVIYELRQKKPEQPAMPAPPTLSPTSIQDPIGTIFRPSGVLRKDSLVANTSGPSLAAVKAMAPPPLSMKSEPTFSTPTGPSAGVSPAGSTPGMSQGDQSTRMGGDSDTADGELEFDQLWGWSTVPSMTSGALAAGTAAAPVGAPPGLATATTASKVPAFPAPGPGQPFRGFPNYIVPGGPNGGGVPTVGPPGYVAPPNVPMYVPAEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBE4</accession>
    <name>H1VBE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SNARE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08853</name>
        <name evidence="11" type="ORF">CH63R_06073</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002511">
        <property type="protein sequence ID" value="CCF37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158898.1">
        <property type="nucleotide sequence ID" value="XM_018301048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBE4"/>
    <dbReference type="STRING" id="759273.H1VBE4"/>
    <dbReference type="GeneID" id="28865155"/>
    <dbReference type="KEGG" id="chig:CH63R_06073"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06073"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_2_1"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="437" mass="48089" checksum="97B66075B06DEB8D" modified="2012-03-21" version="1">MAQYGYVSLSHGADGTHDDEYDLSDRGVLTDTGRYGGRQNPFDQRDDGPGGYGGAPAPSPYGGGNRYNNQGPTMGRDLDGTNVEMESLAQNASGFGQSDPNAILNECRSIDQGIDQIEANLNQLRMLQERTLTDADTSASSSTARQLDALSSETMTMYRSLTDRVRTVKSSPDGQTPRNSPQVGRVDRRLKGAIQQYQQVESAFRKRTQDQMARQYRIVRPDADEREVREAVEDAGAGAQIFQQAVMQSGRQAQANAVLNAVQDRQAALQKIEQQMVELAQLFQDMDVLVVQQEAAVTQIEQKGEEVVENLDKGNQEIGVAVNTARKTRKKKWWCLGICVLIIIIIVAVVAIYFTVIKPQQQQPASNPAKRSIQLPEFSVTVPLDTGAAHPQLFKTTSRIMRRMVRPGATWEPTANAQDTALISRFGGKVDMPAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCC2</accession>
    <name>H1VCC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phosphogluconate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00265</name>
        <name evidence="8" type="ORF">CH63R_10806</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
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    <dbReference type="GO" id="GO:0051287">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
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    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
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    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
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    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
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    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="276"/>
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    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="161"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF37875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="294" mass="31304" checksum="605EE9A46F5E6FC6" modified="2012-03-21" version="1">MAVNLHRKLQSHGARLTFSNRTICKGATLEEAGATAKKNIVEVAQVCDDIFTMVSADAVLLSLVEELLASGIDLMDKTFIDCSTIHPDTALAVSETLRKAGANFVAAPVFGANPVAQAGRLIFAMAGPRTTVERLEPLIIDVMGRKIINMGEDVKKSPMLKVTGNVLLVVFLEAIAEAQVLAEQNGIGTDVMEDLIFENFGPVLGSYSRRLTSGSWAPKEGTAGFLVSNTIKDANHALRVANSLGVRMPALDIATNNMLSARAYGGENLDGAALYGTLRSQAGLPFWSENSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFX1</accession>
    <name>H1VFX1_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10038</name>
        <name evidence="3" type="ORF">CH63R_12544</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003324">
        <property type="protein sequence ID" value="CCF39124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151935.1">
        <property type="nucleotide sequence ID" value="XM_018307518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFX1"/>
    <dbReference type="STRING" id="759273.H1VFX1"/>
    <dbReference type="ESTHER" id="colhi-h1vfx1">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28871625"/>
    <dbReference type="KEGG" id="chig:CH63R_12544"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12544"/>
    <dbReference type="eggNOG" id="KOG1516">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_006586_10_3_1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="50"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="601" mass="65970" checksum="354254D6C0CCB98B" modified="2012-03-21" version="1">MSTAIDQRPSWQWALGLPLAAAGLLGYLWAGPNNAFTTSQHAGSRYSPAASVTINQGTVLGRLVTDGTFPEPVEGFMGIPYALPPVGQLRFRHAVPVPSGNDTLRAFELGPRCPGKQLVPFTNDEWLGPDWQSEDCLTINVYRPRGHTADEGGRKLPVAVMIPGGAFNRGAARMHNTPSMLAWSEEPWVGVSMQYRVGVAGGLNTALTEKEGLLNLGLKDMYVALEWVQENIAAFGGDPDHVTIMGLSAAAHGIGHLIMDVNQKKKLFHKAIMDSGGHTARVVHPPDSKLNEAHFQEFLELTGCGNRPEHEILPCLRALPSSTIIESGQTVYERSNPSVRWAWQPVLDGDIISRRPIDAWKSNRWNKVPILTGSAHNEGAMYVPRTASTPGDFTDFFRTLLPQLSEADLAELNALYPDPSTDPGSEYVETRPLDVGSQYKRAEAAYGHYAYTCPVRQTAVWGSRHAGDPPVYLYHWALNKTALYGANHGDQMRYQTYNAEVRSISPKQDEIAAAMHAYATSFIVHGDPNRFKARSDGGLPEWLPFGGGRQGEEAGKTMVLGEGNNERAGGSGLGTTARFTAYNWAERECDFWWKLTEKFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VHL1</accession>
    <name>H1VHL1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_10474</name>
        <name evidence="4" type="ORF">CH63R_11710</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003651">
        <property type="protein sequence ID" value="CCF39714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153525.1">
        <property type="nucleotide sequence ID" value="XM_018306684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHL1"/>
    <dbReference type="STRING" id="759273.H1VHL1"/>
    <dbReference type="GeneID" id="28870791"/>
    <dbReference type="KEGG" id="chig:CH63R_11710"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11710"/>
    <dbReference type="eggNOG" id="ENOG502S7AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047435_2_0_1"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF39714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="450" mass="49028" checksum="C9676A9A8E800950" modified="2012-03-21" version="1">MALTVKQLNADASFLLTFEPIVPEPIPGVTTRPFRILMDPWITGPSTIFHSILSTATHKEYPCVCSLQHLPEPDLVIISQHKSDHCNEATLRQLPAAGTKTLILAEPAAAKVIRSWNYFNKDKVHTIPRWEDPHTTGKHSVVRVKVPPFTPGGEPGEVSVAFIPQRRDFKGLHAAVGITYRPPPTWPRFTHLLTPPETPTPQQSRLITPQVSMVPHQKPKNAPAYLSLPTPPETPSSRSLSSVRSGASVVPALDARDRAVSVIFSPHGISYRCLEKYASTHLKAEAALPLTALLHCFDTVSNPWWLGGNISTGMPAGQETAAALGAKAWVSTHDGDKDVRGLVTRMLRTKRYTQKQIAGPSQSGKRRGDKRTGREKAGDKEKDGKGTEVLVLGVGEEVAMTGEGVWNVEPGARVLPSAGKVLEDERKLRGRARGRGLTPVNTTAKYGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VI52</accession>
    <name>H1VI52_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CorA-like Mg2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_10616</name>
        <name evidence="9" type="ORF">CH63R_02622</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003765">
        <property type="protein sequence ID" value="CCF39905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162413.1">
        <property type="nucleotide sequence ID" value="XM_018297597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VI52"/>
    <dbReference type="STRING" id="759273.H1VI52"/>
    <dbReference type="GeneID" id="28861704"/>
    <dbReference type="KEGG" id="chig:CH63R_02622"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02622"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_6_1_1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF39905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="626" mass="70234" checksum="4B2D14AC48EF63AE" modified="2012-03-21" version="1">MSDHEENTSEGVFKTPIPELDDHRHQVAASLHPERPRRGTFDTLYGARLLGPESVSGEQSPSILVRDFEEAIVDDEGGDVSPSARRVRRPTVETTTDQRSVSPPNSVKAFAEARRRERGMSFSESKAERNASEEDLHRTVSISSRRSHRSRPYTADDGASLATNQSAAEDVCFPLQDPRRKDQLYIDFDYLENFIHSDRASRTASRRNSARSFPDLRQQQTSDGGPPQLQLSTVDGDILNMPSDSSVGQDASEQEKEPPIEHVKAKPTTTQQPLDPNRFSFFSSAWESTIHAAELGDLVLPGEDLRGLFALPADESDGVWWLNVNSPTKEEVTAICKAFGIHPLTIEDITTQEAREKIELFPSYYFASFRSFHAVQEDDGLEYEPYNLYVVVFREGTLSFSFEPNAHASHVRKRIALLKDYVALSSDWICYALIDDIVDCFAPVIRDIELEADAIEDGVFVAREDDSNQFLRSIGRVRKNTMALMRLLGGKADVLRGFTKRCNENYKVTPRMDIGLYLGDIQDHVVTMVTNLGHFEKILSRSHSNYLAQLSINSISQGTHTNLVLSKITFLASILVPLNLVCGLFGMNVWVPFQDTKSLAPFFTILGSLIIFSIVSLTLARKYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIA2</accession>
    <name>H1VIA2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alternative oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_00334</name>
        <name evidence="6" type="ORF">CH63R_09665</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003791">
        <property type="protein sequence ID" value="CCF39955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156662.1">
        <property type="nucleotide sequence ID" value="XM_018304639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIA2"/>
    <dbReference type="GeneID" id="28868746"/>
    <dbReference type="KEGG" id="chig:CH63R_09665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09665"/>
    <dbReference type="eggNOG" id="ENOG502S5IM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026659_0_1_1"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF39955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="467" mass="52375" checksum="79C7C16A0BA9944C" modified="2012-03-21" version="1">MGFSVLYTSRRFARYIAVTVAVVIFLILGIQTRVQQVDYGLSIQATSAANDIFDFPPIESEAIKSVCAATEWDTRTAMKVVFTCENSVGGVGNIRNSVLNCVRYAMLAGGSLVMPRIVARDDSDINVIRTGERRELGYMFDVEHFVESLRLSCPQLRLYNNTDAAFKVLGQPRTFTMGLFPESLVDENGVPNTGISHPEQWKGKLYEWLGQVDTQMGPTGQPTQGPFTVELGRSYLSFPIYSDGDSFATSFGDILKFRTDTRQLATKTLRRMAEQFNFESTLLEAVSAAKNTSPPKSPILENAYFGAHLRVERDALINWSPTMEMWAWSDYGKQTTAYMEQAINANLSLIYVASGETAHIETFKTEAATKGITVIKKQDILGKDLEKLDKLAWDQQALVDYLVMLRASQFGGVAHSSFAWNVALKRHLFVKDPKKSYLDGPQMLSDEFSQVYGEPRKYPEYAFCLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ92</accession>
    <name>H1VJ92_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_10898</name>
        <name evidence="11" type="ORF">CH63R_12788</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02003991">
        <property type="protein sequence ID" value="CCF40295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018307762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJ92"/>
    <dbReference type="STRING" id="759273.H1VJ92"/>
    <dbReference type="GeneID" id="28871869"/>
    <dbReference type="KEGG" id="chig:CH63R_12788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12788"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="27"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF40295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR03661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="385" mass="41726" checksum="882F618F50D55242" modified="2012-03-21" version="1">MSSQPPHPTLLIPGPIEFDDAVLQAMSHYSESHVGPGFVNTFGEALSMLRQLFQTKDPQAQPFVISGSGTLGWDLVAANLVEAGEDVLVLATGYFSNGFTDCFKTYGGNVTELRAPVGSRPQLPEIEKALSEKKYKVLTVTHVDTSTAVLSELKELTALVKRVSPETLVIVDGVCSVGVEEIRFDEWKLDGVITASQKAIGVPAGLSISMFSGAAMKSFAQRKTPPASYFGSFKNWTPIMQNYEAKKPSYFATPSPQLIHALHTGLTQILAKPLSERFDKHKEVSDKVKKAVADLGLKQVAAKPEDQAHGMTAIYLPESVKAAELLPSLAKKGIVFAGGIHKEIAPKYIRFGHMGVSVTDPNRKDIDNAIKALQDSLFEVGYQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJH5</accession>
    <name>H1VJH5_COLHI</name>
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        <submittedName>
            <fullName evidence="4">2OG-Fe(II) oxygenase</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_10959</name>
        <name evidence="5" type="ORF">CH63R_03476</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004041">
        <property type="protein sequence ID" value="CCF40378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163267.1">
        <property type="nucleotide sequence ID" value="XM_018298451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJH5"/>
    <dbReference type="STRING" id="759273.H1VJH5"/>
    <dbReference type="GeneID" id="28862558"/>
    <dbReference type="KEGG" id="chig:CH63R_03476"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03476"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="219"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="42478" checksum="B4CB8C60D8C014B2" modified="2012-03-21" version="1">MSTAAVVSEPGTTLLRFASGNGTVTRRILTTPLRDALPAEIPIIDISLAFSPELADRKIVAHQIREAATTSGFFYLDNHGIDPSITASAHTACLDYFRQGEEAKMQSWVGKSRYFNGYKPPGSQRINKSESVDNRESFSWTYDPRYDTDITDVGAIPERVRRFLRMEDFHWDGTSNMPHFKKAIIRYWQSCLKLARVLVRAFALSLELPEDFFDAKFAYPDAALALNYYPPLPKPAGNAESDTNTQVSIGSHTDFQLFTILWQDAVGGLQVLNRQGQWIRAAPIPGTFVVNIADYLQRITNDLYVSTVHRAQNLSGEERISMPFFFGFGLHESCGVLETCVEDGERPKYDEIGCEEWVQRRARAMHKVESDDESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJV9</accession>
    <name>H1VJV9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00356</name>
        <name evidence="3" type="ORF">CH63R_06707</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004124">
        <property type="protein sequence ID" value="CCF40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159532.1">
        <property type="nucleotide sequence ID" value="XM_018301682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJV9"/>
    <dbReference type="STRING" id="759273.H1VJV9"/>
    <dbReference type="GeneID" id="28865789"/>
    <dbReference type="KEGG" id="chig:CH63R_06707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06707"/>
    <dbReference type="eggNOG" id="ENOG502S564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052686_0_0_1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46504:SF2">
        <property type="entry name" value="TRNASE Z TRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="324" mass="36185" checksum="419B59BD7AEBF927" modified="2012-03-21" version="1">MASFATPLPQSSRSEVLEWRFPKPYHQYVLTGKSRAAWHTSFVIPQLNLLLDAGLVVNNHRPKHIFLTHGHADHCLLIPAFTKREDPPDVFCPVEMKKALDDFILAKTLLNRGGLYTSNDAESVGLELDGKGVDEEGRTEGERAFLGTHKTTAVKHGDVVPLRRLKGMNATVVQCDHNVPSVGYVFTTTTHKLRPEYTSLPGPELKSLRQSGVELTAPVTTPVFAFLGDTTASTLAADPEWLRQGIPVVITECSFLHDEHDAQAEKTKHTKWKDLEKVVRRWPKTTFILTHFSMRYSNKDVVAFFNGLEDAPANIVVWADGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKQ7</accession>
    <name>H1VKQ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_11280</name>
        <name evidence="12" type="ORF">CH63R_05611</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004314">
        <property type="protein sequence ID" value="CCF40810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158436.1">
        <property type="nucleotide sequence ID" value="XM_018300586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKQ7"/>
    <dbReference type="STRING" id="759273.H1VKQ7"/>
    <dbReference type="GeneID" id="28864693"/>
    <dbReference type="KEGG" id="chig:CH63R_05611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05611"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030430_1_0_1"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF40810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="533" mass="59594" checksum="A6F712B0F8274A65" modified="2012-03-21" version="1">MIRFLVLPRYGSQSTPVITAAAFIALAVVYLLRFNGHITPFTSASFSFRTSRVSGLNLDAINSTAQYFVDYPLGPPYKKVFGELGERTKVLRSWIEALEEKNGGGNGDGLRVVGAERQFLDETVERVASSLFPYLQSPPRDIHSQSPLADLRRSFSTAGAHARHPTQQQQQQRVGGDGDTTMGYTHRNAGIVIPTGRGTLRFACHLVASLKHVHRTKLPIQIVYAGDEDLSQENRDTIAEAAAGGDDGHVEFLDILTVFNDTTLRLAEGGWAIKPFAALGSRFEEVILLDADVVFLQPPEQLLQQRAYRERGALLFHDRLLWKDEFPDRHAWYHEMLKHPSEELQKSLVWTEKYAEEGDSGVVVLDKGRLDVLMGLLHTCWQNSYDVRTSWTYRITYGDKETWWIGLETTGAAYAFSRHYGGMVGWRTPLAGGGGSAQTGQTQVCSFVIAHVDETDDLLWYNGGLLKNKMDDPAEFSVPTHWMIDQQWVKGARKKDMSCMVGTNARVLSTHETGVLEQSVEAAKDVDYRLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLN2</accession>
    <name>H1VLN2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_11506</name>
        <name evidence="2" type="ORF">CH63R_05030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004511">
        <property type="protein sequence ID" value="CCF41135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161251.1">
        <property type="nucleotide sequence ID" value="XM_018300005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLN2"/>
    <dbReference type="STRING" id="759273.H1VLN2"/>
    <dbReference type="GeneID" id="28864112"/>
    <dbReference type="KEGG" id="chig:CH63R_05030"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05030"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000131">
        <property type="entry name" value="HAD superfamily hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="309" mass="34655" checksum="4D0A98097208E857" modified="2012-03-21" version="1">MAPRTDFPPIRACLFDMDGLLLDTEDLYTACINLILEQYGRPLLPWNIKAKLQGRPGPDATRIFHEWAQLPIAHDEYHQKLSAHQRELFPTTGPLPGVPDLLQNLGRTRYWDLKPRADGNKDPHRVHIALATSSHEANFKLKSDHLTELFSVFPSHRRVLGDDKRIAPGRGKPNPDIFLLALKTINESLGDGEKPITPEECLVFEDSVPGVEAGRRAGMRVIWCPHKGLLKEYAGREKEVLAGRTGEAGQVDMHQVGEIDDGWAEYLPTLEDFPYEKFGMTIPPVEVDNEPFMKENVGDVLVDKTNGSA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNM5</accession>
    <name>H1VNM5_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11992</name>
        <name evidence="4" type="ORF">CH63R_04058</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004964">
        <property type="protein sequence ID" value="CCF41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160279.1">
        <property type="nucleotide sequence ID" value="XM_018299033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNM5"/>
    <dbReference type="GeneID" id="28863140"/>
    <dbReference type="KEGG" id="chig:CH63R_04058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04058"/>
    <dbReference type="eggNOG" id="ENOG502S9H1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120625_1_0_1"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="121" mass="13140" checksum="86D3191002C4D904" modified="2012-03-21" version="1">MNTVKSFWLGWGSLCVAGGTAYYFAKQSINADRAARFEEQRKKKMMAQSLEYGDNVPAQSGSVANMGGDARTDTAGSPSQESSSDPAPTRHAPATESERVFEKSKYESSTPFKSPKGDRFS</sequence>
</entry>
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    <accession>H1VQA7</accession>
    <name>H1VQA7_COLHI</name>
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            <fullName evidence="8">Bax inhibitor family protein</fullName>
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        <name evidence="7" type="ORF">CH063_12420</name>
        <name evidence="8" type="ORF">CH63R_07072</name>
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    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
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    <dbReference type="EMBL" id="CACQ02005365">
        <property type="protein sequence ID" value="CCF42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156825.1">
        <property type="nucleotide sequence ID" value="XM_018302047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VQA7"/>
    <dbReference type="STRING" id="759273.H1VQA7"/>
    <dbReference type="GeneID" id="28866154"/>
    <dbReference type="KEGG" id="chig:CH63R_07072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07072"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="279" mass="30702" checksum="CF7A8FE6E8F94452" modified="2012-03-21" version="1">MASNAKYAPAPTQDPDEASSYQAPPAYQAEPTAASDTDRLFGGGAPRSSEDDLPDDFKFGGSVAEATTDIRNQFIRKVYAILTVQLLVTGAVSALSFFSDGYKNWIQAHPGLVFASLIGAVVMMLLTFWKRKSYPTNLLFLSGFTLMEAYSISVIVSFYKAGIVLNAVFLTAGIFIFLTAFACQTKYDFTSWIPYLGGALWGLVLFGFMYMFFPYSSTGELVYGGIAALIFSAYILVDTQLIMRHHHVEEEIAAAISLYLDIINLFLAILRILNSQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQX3</accession>
    <name>H1VQX3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_12573</name>
        <name evidence="12" type="ORF">CH63R_03717</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005530">
        <property type="protein sequence ID" value="CCF42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159938.1">
        <property type="nucleotide sequence ID" value="XM_018298692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VQX3"/>
    <dbReference type="GeneID" id="28862799"/>
    <dbReference type="KEGG" id="chig:CH63R_03717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03717"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="510" mass="55432" checksum="CE0B778570F7ABF4" modified="2012-03-21" version="1">MYRIYNIYALAAIGTIGGMLFGFDISSMSAWIGADSYKEYFGFPSSTLQGGITASMSGGSLVGALVAGFIADWWGRRGALKLASVIWIIGAVLQCSSQNVGHLIAGRVVSGLAIGITSSQCCVYLAELAPSRIRGRIVGIQQWSIEWGILIMYLISYACVVTIDSPKAFRIAWGVQGIPGLILGVALFFFPESPRWLAQKDRWEECHEVLAHLHAGGDREAPVVLAELDEVKDAARIAAESKHIGVLGLFGPRVWKRTLAGCSVQVWQQLLGGNVMLYYLIYIFNMAGMTGNTALTSSIIQYVIFLVTTGAILPIIDRLGRRPLLIGGAIICCIIHFTTGAVMKVHGNPVDEVDGDENLKWAISGAPAQGVIALCYIFVGVYGLTWAPIGWIYASEVFPLKYRATGVGFAAACNWAFNLALAFFVPPAFTNIQWKTYMIFGTFCAAMTVHIFFTYPETSGKTLEEIDALFDSNVPAWRTRSAGVRFEDRVAAAESKKNGFNATHVDQVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VU97</accession>
    <name>H1VU97_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_03163</name>
        <name evidence="14" type="ORF">CH63R_02252</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CACQ02006390">
        <property type="protein sequence ID" value="CCF43806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162043.1">
        <property type="nucleotide sequence ID" value="XM_018297227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VU97"/>
    <dbReference type="STRING" id="759273.H1VU97"/>
    <dbReference type="GeneID" id="28861334"/>
    <dbReference type="KEGG" id="chig:CH63R_02252"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02252"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_1_1_1"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF43806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="632" mass="71245" checksum="0AF238CC1EB44BA6" modified="2012-03-21" version="1">MASVGSPLARPELLMAVRNEHNKPAVFRSLLVIRLLNAWWVLTFFQPDEYFQALEPAWRMAFGESGGAWITWEWRNQLRSSLHPALFAGVYYLADFVARPLPFARPWLLLAAPKAAQAVFAAAGDWYTWQLAVKIYGADSSISWFALFMSMFSPFQWYCSTRTFSNSLETTLTVMALNYWPWELLGESRPEKENPKPAKSILHAPGVLMSLRLSLTLAAIAVLLRPTNVIIWATVAIATLARPLFTRSSVLTAQTFLILIREAIFCGTVVISLSLASDRLYFGHWAFPPYKFLYFNLSQSLAVFYGRNDWHYYLSQGLPLLSIAYLPFVLAALYRPPSTPSGTRTQTLKTLSRIVYIVIATLSLVSHKEVRFIYPLLPVLHVLAASPLTSFFTSPAPSPTPKSPLPKPRLRHKRLLTSALALHALLSFFLTLLHQPAPLTVLAFLRNSYSRLHTATSVSSSPISVASAVTNSSSEELFALFLMPCHSTPWRSHLIYPTLRARALTCEPPLHTAPNTPERIDYRDEADRFYDDPQHFLATEMWPVAAKHTGDPDADMNASLAPSAKAEDIPRYIVGFEGIEPWLLDFFDGPRGRDFGVRPKRVWQGWNGFFNEDSRRRGKIVVWDTGLYTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWT9</accession>
    <name>H1VWT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_03405</name>
        <name evidence="7" type="ORF">CH63R_13047</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007101">
        <property type="protein sequence ID" value="CCF44701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152438.1">
        <property type="nucleotide sequence ID" value="XM_018308021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VWT9"/>
    <dbReference type="STRING" id="759273.H1VWT9"/>
    <dbReference type="GeneID" id="28872128"/>
    <dbReference type="KEGG" id="chig:CH63R_13047"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13047"/>
    <dbReference type="eggNOG" id="ENOG502S31Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_2_1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497774" evidence="3">
        <location>
            <begin position="17"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF44701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="319" mass="35819" checksum="9590430654523CC1" modified="2012-03-21" version="1">MRVSYLASAFIGVVVSAPLTQNIHCQNPAVRQEWRLLPKETQQSYVDAVKCLKTKPSRIGRNLTTTLYDDFPYIHAHLDTSIHFVASFLPWHRYFVHVYEKALQDCGYIGVAPYWDWTLDVANVSTSTIWDAESGFGGNGLRPYPSGSDAEQNCVQDGPFKDLRVEYMALGAEEHCLRRNFNNGSEEIGDMFAGAYTPEAVQVINNLTAYDNFRIGLENGPHGAIHSSIGGDMSPSTSPNDPIFFLHHGQIDRLWTLWQNEQLENRTLDYSGIRTQDQFDGTTPPAASLEDIMPMYGLADDVAVKEYMSAQSGPLCYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ96</accession>
    <name>H1VZ96_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_03637</name>
        <name evidence="6" type="ORF">CH63R_04183</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007856">
        <property type="protein sequence ID" value="CCF45558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160404.1">
        <property type="nucleotide sequence ID" value="XM_018299158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ96"/>
    <dbReference type="GeneID" id="28863265"/>
    <dbReference type="KEGG" id="chig:CH63R_04183"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04183"/>
    <dbReference type="eggNOG" id="ENOG502S7T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093936_1_2_1"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="11"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF45558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="167" mass="19247" checksum="C7371D868978FE95" modified="2012-03-21" version="1">MEPKVFFTVVQGNGNPPQVIKDLYTFTPAVLTGYTRHRVQFADYPGMIPEDDGSVLGIYATGLTDANVSKLDFFEGSEYEKKIVKVKIRSGEDGGEEEEREATAYIYKHPKNLERREWSFDEFRRDKMHVWTRESYVFEGCDDFAEFEKTEYEDKDGSAEQVKQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZM9</accession>
    <name>H1VZM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03678</name>
        <name evidence="3" type="ORF">CH63R_14016</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007978">
        <property type="protein sequence ID" value="CCF45691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151308.1">
        <property type="nucleotide sequence ID" value="XM_018308990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZM9"/>
    <dbReference type="GeneID" id="28873097"/>
    <dbReference type="KEGG" id="chig:CH63R_14016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14016"/>
    <dbReference type="HOGENOM" id="CLU_2346572_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="97" mass="10361" checksum="9F4E7EE40EF1E800" modified="2012-03-21" version="1">MRVVSVLLRDDSAGMPPPPPLCSTSSRLFSIFLENLSVINPGRFGSFGLTAVGMYAIYTSDGGTEDHSTSVATISHPRPAAQRKQNLPAKRGRAQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1W086</accession>
    <name>H1W086_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_14827</name>
        <name evidence="11" type="ORF">CH63R_10323</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008149">
        <property type="protein sequence ID" value="CCF45898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154721.1">
        <property type="nucleotide sequence ID" value="XM_018305297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W086"/>
    <dbReference type="STRING" id="759273.H1W086"/>
    <dbReference type="GeneID" id="28869404"/>
    <dbReference type="KEGG" id="chig:CH63R_10323"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10323"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF45898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="289" mass="31721" checksum="5C3E70C0043D96E1" modified="2012-03-21" version="1">MASSYQYRNSYHNSSSQNISEKYDEGLGRPATSRRNTRLRSSDGTVSTTMSSSTGRESAATHVTEGPAYSKKIVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITYPTHPPSGKTVELALWDTAGQEEYDRLRPLSYPETDLIFVCFAIDCPNSLENVMDKWYPEVLHFCPYTPLVLVGLKSDLRFKKTCIDMLKTQGLTPVTQEQGRAVARKMGAQYAECSSKEMTGVDEIFEQAILTVVANDRKNVEAQAAVSSSTSGGPPGSSAGIPSVALKKKKKRNCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1P3</accession>
    <name>H1W1P3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_03866</name>
        <name evidence="5" type="ORF">CH63R_12002</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008667">
        <property type="protein sequence ID" value="CCF46406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153817.1">
        <property type="nucleotide sequence ID" value="XM_018306976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1P3"/>
    <dbReference type="STRING" id="759273.H1W1P3"/>
    <dbReference type="GeneID" id="28871083"/>
    <dbReference type="KEGG" id="chig:CH63R_12002"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12002"/>
    <dbReference type="eggNOG" id="KOG3478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125172_1_0_1"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF46406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="124" mass="14020" checksum="0716596CE6C2C428" modified="2012-03-21" version="1">MAEIQAKLQKLSEEYTALQQELQNTVQSRQKLEAQKQENLGVKEEFDKLKDGEQIYKLVGPVLLKQDKVEAESTVNGRLDFITKEIERHEDLIKEGQGKLERKKGDIIQLQTSAQAAAGQAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1W262</accession>
    <name>H1W262_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03898</name>
        <name evidence="3" type="ORF">CH63R_06995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008834">
        <property type="protein sequence ID" value="CCF46575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156748.1">
        <property type="nucleotide sequence ID" value="XM_018301970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W262"/>
    <dbReference type="STRING" id="759273.H1W262"/>
    <dbReference type="GeneID" id="28866077"/>
    <dbReference type="KEGG" id="chig:CH63R_06995"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06995"/>
    <dbReference type="eggNOG" id="ENOG502QT25">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043688_0_0_1"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF46575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="377" mass="42983" checksum="360B21388992E697" modified="2012-03-21" version="1">MPAGTGITEVSGVKRADVHKQVKQLIHDMVNINDTTGEFLMTLEDGRVIDTKGWEDWEWTHGIGLYGIWKYYELNGDPADLKIIEDWFKNRFAEGHKGKNINTMAVFLTLAYVYEKTGNETYLPWLDSWAEWAYHDLPRTKYGGMQHITYLEVNDQQLWDDTLMMTVLPLAKIGLVLNRPHYVEEAKRQFLIHLQYLFDAPSGLFFHGWTFHEGGHNFARARWARGNSWLTIVIPEFIELLDLAPQDSLRSHLVNTLEAQCAALVPLQVDSGLWRTLLDVPEDEGSYVEASATAGFAYGILKAQRKRYIGKEYEPVAVKAVKAVLDNISPEGELLHTSFGTGMGHDLQHYKDIPQTSMPYGQAMAMMALVEFLRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3N1</accession>
    <name>H1W3N1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_04053</name>
        <name evidence="5" type="ORF">CH63R_12077</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009357">
        <property type="protein sequence ID" value="CCF47094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153892.1">
        <property type="nucleotide sequence ID" value="XM_018307051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3N1"/>
    <dbReference type="STRING" id="759273.H1W3N1"/>
    <dbReference type="GeneID" id="28871158"/>
    <dbReference type="KEGG" id="chig:CH63R_12077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12077"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_2_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF47094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="337" mass="36110" checksum="AB6B587292098DF8" modified="2012-03-21" version="1">MIPQKAPPPSQQQQQTMPAALPVVDLRSFATVEDLAAELMRVGRDPGFFYVVGHDLGDAAAAAVFARAESFFNAPLPDKLAFANGSGDLGYTGLREETLSGAGPGDVKESFYLSDPGRTTQPLPAELEAGRKGMAAFFAACDVLAKTLLEGIAVGLGMPKDFLSRAHTGESCRMRLINYPPVSRLPSAPDGGQDIRAGAHSDYGSLTLLFRQPSDQGGLQVSRAGAWLDVPCLPDAVVVNTGDALEFWTAGRLRSTVHRVAFPRSASENVGRLSIPVFIQPDRHVVLAPIEGPGDKPEGGFGAEFLEVLRRKGYEDARPVTSSEHLERRIRATYARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQC6</accession>
    <name>A0A1B7XQC6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nacht and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150469.1">
        <property type="nucleotide sequence ID" value="XM_018309497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQC6"/>
    <dbReference type="GeneID" id="28873604"/>
    <dbReference type="KEGG" id="chig:CH63R_14523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14523"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR01951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="271" mass="30351" checksum="67797B52EBBA351E" modified="2016-11-02" version="1">MALWQYGTTNAASVINHMIRTFTNLRFCLMVGIGGGVPTKRDIRLGDVVVSAPDHGRGGVYEYDYGKTLQNKAFEPTGALNQPPLELLVAANALRAEYEFKGMSFVEQIAAKVQRLSPDVHSKYSRPRNDRLYMPNVIHDDQSRKTPCCQNLDESPKDESSLLVRRPARHSEEPIIHYGLIASGNKLMKNAETRDVLAKNHDILCFEMEAAGLMNQFPTLVVRGICDYSDSHKNSEWQGFAALAAALYARDLLLEIAPTTAENSERLREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQE7</accession>
    <name>A0A1B7XQE7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150472.1">
        <property type="nucleotide sequence ID" value="XM_018309500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQE7"/>
    <dbReference type="GeneID" id="28873607"/>
    <dbReference type="KEGG" id="chig:CH63R_14526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14526"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR01954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="164" mass="18077" checksum="D0A28496C1FAA656" modified="2016-11-02" version="1">MVESGNEFFADYEPHNTSVLSILSNLDFGIDEDIKDATLTYFVVGFHDHLEDDPLSVANTVQKKISSHMPQHAERRALLAVESGHQGQISVSQASKLAKEHQPVAVSTNTLNALLAFLQMQYEGDERGSTQTKQTLTKIVQLVLSNNEIDAQQKASYQVSTMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSY0</accession>
    <name>A0A1B7XSY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151352.1">
        <property type="nucleotide sequence ID" value="XM_018309034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSY0"/>
    <dbReference type="GeneID" id="28873141"/>
    <dbReference type="KEGG" id="chig:CH63R_14060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14060"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="258" mass="27742" checksum="B6B8D8DB6F66719F" modified="2016-11-02" version="1">MEAIQTHPTSAAQAKAFTAPGSLSFPGGAHELPPAPVVNGDKAPVNGQAPVANGQQGANGTGVTPATPAATPAATQGGSGLTPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT67</accession>
    <name>A0A1B7XT67_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS1 nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151478.1">
        <property type="nucleotide sequence ID" value="XM_018309160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT67"/>
    <dbReference type="GeneID" id="28873267"/>
    <dbReference type="KEGG" id="chig:CH63R_14186"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14186"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="63179" checksum="B5B936D68EFEE6A6" modified="2016-11-02" version="1">MKGFNRDELRLRCTSVKAWELPRHSSSALAPEGVWTNEDMDPVKPEDQTWSIWTILAYWSSDLMNLSTLQTAGSILAVGLSWRESIPIMFVGTTCIAVAMVLNGAIGSRLHLPFSVIAAGSFGYWFRYFAIVSRAVLAMFWLGVQCANGSYCITIMLSAWAPSYARIPNTLPESAGITSMGMCSFFLFWILQLPMLLIHPTKLRPLFYVKLIATPAVVLGTLGWAVKKAGGGGEIFKLQPEVPKGTAQYAWLWLSCMSSVTGQWATMGVNIPDFLRYSKSPNGQLVQLPFVPLVFTLCGTMGIITTSATKTFHGEYLWNPLDIVSLWLENGSGGRCAAFFAAFAWFIATVGTNVTANSISAANDLTIMFPRYVNIKRGSLIAAVIGGWVLVPWKILASATTFLNFMGAYAVFLAPISGILAADFWIVKGQKYDLPGKYYLARAGFPFCLYDPHGRYRYVAGCNWRAFVAFIVPVAPSLPGMALAISGYPAVQISEGAQHLYSFDWLFGFVVSIFLYTTLSWLAPAKETLVERTIWTKDGADVEATSRGSDVEDPKLPEKGHTTATRVISDDDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTT8</accession>
    <name>A0A1B7XTT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhamnogalacturonase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151700.1">
        <property type="nucleotide sequence ID" value="XM_018307283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTT8"/>
    <dbReference type="GeneID" id="28871390"/>
    <dbReference type="KEGG" id="chig:CH63R_12309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12309"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601065" evidence="11">
        <location>
            <begin position="22"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR03182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="445" mass="46110" checksum="C130632F09CA5C40" modified="2016-11-02" version="1">MKFTSVSLLALGALLPGFGSAQLSGKVGPSTTAAAKAAKKSCKITDYGAKAGATGDIGAALKSAWNACKTGGEILIPEGEWGLGTWQTLSGGSGVSINLEGTIYRTGTAGGHMIIVQKSTDIEFYSSNSKGAMQGYGYEFHKQGTSIYGPRLLRFVSVTDFSVHDIALVDSPAFHFVMDTVTNGEVYNMIVRGGNRGGLDGFNLMAAKNVHVHDVAVTNKDECVTVKNKSSNVLIENVFCNWSGGCAIGSLGADTAISDIHYRNVYTSNSNQMMMIKNNGGDGVFQNAKFENFIGHGNAYSLKIDAAWAGQSKASGDGVEYKNLTFSNWKGTAANGASRGPVVALCAAAVPCENIDVSGINIWTEAGSSIVDKCNNAFGKGHCLRTGSGTYTSTATTKTVTGYSAATMPGLVTAGLGLTKSIDIPAIPTTFYPGATPLSALAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU62</accession>
    <name>A0A1B7XU62_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fic/DOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151827.1">
        <property type="nucleotide sequence ID" value="XM_018307410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU62"/>
    <dbReference type="GeneID" id="28871517"/>
    <dbReference type="KEGG" id="chig:CH63R_12436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12436"/>
    <dbReference type="OrthoDB" id="439046at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="169"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="267"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="344" mass="39178" checksum="60A7D581F6910A47" modified="2016-11-02" version="1">MFAGLRSVISNGWPVRAQETKEVVSIRPDDIYTQHSSDQNPQKLFEKASSWLTIIQEKRMDQVQTELVLKETQDTLIRAIFGSNMIERAGLGWDITLNLCRIVFAGEHVGDIPERTSKYENQLLDLQYQEGDNESIASQNFHRGRLEIVQHARAYQHILHQVVVKQDDLTEDLIKETHRILTRGIPIVEKGFPDVPPEKYGGIYRKVPVGAGSTMFTVPQHVPGKMREMCDKLKADIEKAEKQNSIDPFSMSSKYSLEFVQIHPFQDGNGRMCRMILNAILARYAGIIVPIGEKVDEITEYISIKRRASESMEGHGEYAMFILKRAVPRLRELKKKLTGKGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUR7</accession>
    <name>A0A1B7XUR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152029.1">
        <property type="nucleotide sequence ID" value="XM_018307612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUR7"/>
    <dbReference type="GeneID" id="28871719"/>
    <dbReference type="KEGG" id="chig:CH63R_12638"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12638"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="87"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="62672" checksum="03362197270C99D2" modified="2016-11-02" version="1">MEDPRMTPDPSEPVRNAEKHCTTSFGGEDVAVTPSQGENMRPKHFDGTTRLIAEGEVILIPTPSEDPRDIVDPLNLPIWHKQLIVGIIVLYAISGLCLLTALSALIVYMMPDYQREGITPDQISNLFTVPNLLLGIGNLVSMPIALAVGRRPVMLASTVLLFMSAVLCATNRNYYWHLGGRMVAAFAAAQCQALALLVIQDIYFLHQRARAFQIYSSAEVLINSSLVIASSYMSDALGWRSWYWMFAGLSGAAMILTFLFVPETGYDRPIEAFMGTHPSDIGNLLPAHLNCVLTSVDIRGQSPGPEYTKIGEGLTADSGRYKERTFGSNLQIFVHKPSWSRCWLCLKQIGQVFLFPHVLWVAINNGLFQGIDVSIQMTYAEVLVKPPYNWANTSVSLIQLGQVFVAILCVPLIGWLSDYIIRCSARRNHGVHEPEQRLVAWVIPMTTALILTVLYGYVLENPEKFHWMAIVCIVDGYLIVLLGANTVGMTYLIDSHPSFAGAILVALPVTRGLVGFGISKHTTQYIANIGSVMTFGIYAAVSATFCLLGIALYFTGKMVRRVCAQMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVW3</accession>
    <name>A0A1B7XVW3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152402.1">
        <property type="nucleotide sequence ID" value="XM_018307985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVW3"/>
    <dbReference type="GeneID" id="28872092"/>
    <dbReference type="KEGG" id="chig:CH63R_13011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13011"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="116" mass="13226" checksum="EA5B833E22D4A715" modified="2016-11-02" version="1">MTMDIALAPILTYQGKACKKKGVKPHKHGMVYHNKPHRLLPNEPELGFPAVRAKLTVEGEKLDKASRVNYSKLVTIEHNVKVFFIGYISPERMDDFAGAVDACWESKTHSHRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW66</accession>
    <name>A0A1B7XW66_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152547.1">
        <property type="nucleotide sequence ID" value="XM_018308130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW66"/>
    <dbReference type="GeneID" id="28872237"/>
    <dbReference type="KEGG" id="chig:CH63R_13156"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13156"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="186" mass="21125" checksum="F0F79F13F55289E3" modified="2016-11-02" version="1">MKVRFQFSGNIWALANNLQFQIGYGGARYIDIRRHQDICELAKPCNCLPPTALVVPQGTEYRCSPIPAKFSPPVGPRLMMDYFTNPDDIPAGSTLVLQQLPKRTCGRLLPQHTEIVEAWGIYYKEDWDWEKIWWLLGLAFFPPSMLFGILWGVLKHDLQSAFGIASWWMTGATIIVGIVGTKSWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWL9</accession>
    <name>A0A1B7XWL9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152685.1">
        <property type="nucleotide sequence ID" value="XM_018308268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWL9"/>
    <dbReference type="GeneID" id="28872375"/>
    <dbReference type="KEGG" id="chig:CH63R_13294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13294"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7314" checksum="A9DDB490FE2E9B43" modified="2016-11-02" version="1">MATVMRKGDNSQGMVGRGAAQRRETVETDETTHPLQRSTDEPELDTARNPTRKKGSQKDCRRDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXZ9</accession>
    <name>A0A1B7XXZ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clock-controlled pheromone ccg-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153147.1">
        <property type="nucleotide sequence ID" value="XM_018306306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXZ9"/>
    <dbReference type="GeneID" id="28870413"/>
    <dbReference type="KEGG" id="chig:CH63R_11332"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11332"/>
    <dbReference type="OrthoDB" id="4828160at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601168" evidence="1">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="264" mass="29164" checksum="2884168D588C9FE9" modified="2016-11-02" version="1">MKYLAVLATVVITTNAVALPEAEAQRWVFRWCRSVGQPCWKVKRAADAFTAAITAADVVVDKRSPEALVSHSEGGEAYMAKRYLNDLAGAVASSQPDPLRYYDGLGLGLRFADDAAEGLGKREAEEEAQRWDTHWCRTVGQPCWKAKNRSADGGEQVTEADLRAEDKRWCSQPGAPCSVAKRAAEALIEAVESPVDGLVVVKPEAEAEAQRWDTRWKEKTKREALCTKPDEPCWKQETNPEAWKAQRHLDAMVVAARAVIENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZF8</accession>
    <name>A0A1B7XZF8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153647.1">
        <property type="nucleotide sequence ID" value="XM_018306806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZF8"/>
    <dbReference type="GeneID" id="28870913"/>
    <dbReference type="KEGG" id="chig:CH63R_11832"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11832"/>
    <dbReference type="OrthoDB" id="4738706at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128922" checksum="4BD1BF5475A53B38" modified="2016-11-02" version="1">MAADPHNLPNPGLDSAIRQLLDQQADIQARLAALLPTKYGPNVKLELNMLRHKLRGLQAYSEVHRLSSNVPINSELEEARSLQYRCECIETAFLEQGFDLSDPSMADALKRSLYDEAPAGYAAWLDRNLTSYDPIVRGWKMRESLSPSSRSASSFKCWDERCIHYIYGFYNKDDRDSHSREHTVHAHRDSGLSVGNTPPLPFPDHTTARPWVSDVGKQPRALQLPKPSIGAQLAPLATASQSRDRSDPLQSYTMASEHSGPGRGSVDSEVDPLLPPLKRSRVGQSRLQSIGELRLLQDSGPCLRCIATRQPCDSNEPCYYCADHPLSPGSDFWKAIGCHRGPLDVLSDVMLPTPVSPIQTQTPITSPLTQRRSMNEHLENHCRISPDILHAVKSNLDFDDGFWWTEGLMNLPLANPTLPNFSREATERPPPILSILTASWNGGATAYNFLHLLKTSGFITPTREMEETAYPVLYRVKVLLREVIFWDLEQPEPSIYLDGGPPHRPPFTDEIDQEAHRRLIYSCMAQFLQAFESATVRKGPQDPKSWLAVFIALCIFSIVRTIMVDMTSCLHRRQSSQTPPTWSGTSSVHAMHSVYKLLVTIFAASGPMLLDEQPFDLDERGRNAMESLNAIVRRDVWIQHGFASSKDFLIHLGDGEMEGTVTFNGFLRQRIPLRTGIVGLPSIVKLGEEPRHAMYDPRALGDPWIPHPAPLSERDHFGTSGGPEFLTSPQGLDSLGRRHTVGESPTFPQGPMRPLESPLTGSRGRPTYQRPPLRRVYCIKCNEYPEGFRGEHELRRHTDAKHASLVRRWVCTEPDSYSPTLPQPVIPLSKCKACVTQKRYGAYYNAAAHLRRAHFNPHRGGKASGDWPPMTILKDWMKEVRQSVDIQDQDDSSGGEDVDYKPPPEYLTQAPPPPPPPPPPVAAVRSPTFGSTILAAAPPNIPLTIAPAEPMSLSQMNSPSNKTLDNRTRCPHPDCGRVFKDLAAHMLTHQEERPEKCPIETCEYHTKGFARKYDKNRHALTHYKGTMVCPFCPGVGTAYEKAFNRADVFKRHLTSVHNVEQTPPNSRKLIIGGSGNIHSDGAKCSICRGYFGTAQEFYEHLDDCVLNVIVPTSAKTHRDASALPSTSGLEERDRLDEENAKPRSPMGEKMDMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0F0</accession>
    <name>A0A1B7Y0F0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154020.1">
        <property type="nucleotide sequence ID" value="XM_018307179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0F0"/>
    <dbReference type="GeneID" id="28871286"/>
    <dbReference type="KEGG" id="chig:CH63R_12205"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12205"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="495" mass="54960" checksum="5C077364A61369B0" modified="2016-11-02" version="1">MDAPQKDRLDEADTGLYPGAGSSDIDARDPVLVDAAAEKKIVRKLDMHIIPLVMLLYLFSFLDRVNIGNARLYNLERDLDMHGNQFQVAVSILFVTYIIFEVPSNLVLKLFTPRRWIAFITVSWGVIATLTGLVHSYGALLACRLLLGAVEAGLFPGLNVYLTFFYSKHELALRVGYLFVSAAIAGGLGGLLAYAIGHMDGVEGLSGWRWIMVIEGLPTVVLGVITYFALPNDAATAYFLTDDEKAVMARRRAREYGNTSSAQEFSRDDMFKAFMDWKVWVFSIAQFGADTMLYGFSTFLPTIINGLGTWTVAQVQLLTVPCYFLGAVVYMCMAFLSDRMQRRGLFCVIFGSISVIGYGVLISPSSNGVHYFGCFLVAAGLYVVVGLPLAWLPNNSPRYGKRTTASGMQLTIGNCSGVMSSFIYQAVDKPRYIRGHAVTLSMVGMATCLYGFLWFWYSRENKQREAGRVQSKYADLSDDELAELGDESPRYRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0K6</accession>
    <name>A0A1B7Y0K6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_12254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154069.1">
        <property type="nucleotide sequence ID" value="XM_018307228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0K6"/>
    <dbReference type="GeneID" id="28871335"/>
    <dbReference type="KEGG" id="chig:CH63R_12254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12254"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF162">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="224" mass="24996" checksum="D5F8AFC90EFB0C7F" modified="2016-11-02" version="1">MRCRELGIRLTDKELQSNASLLVMVGYDTTATSLSATMNLLLRHPKRLAELKEELQQHYPSAADMDATSLGQLPMLNGCIQEALRLFPPANGKGTNRTSPGVSIDGVYIPQGINVSADMYTIQRSSLYWTRPDAFCPERWFNNGPGTEFANDIRSSHCPFLLGPRMCIGRAVALQSMRMVLAKIVHSFELQAAETYNWETDVSSSYLWTGYRCMARVAHGQTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1A1</accession>
    <name>A0A1B7Y1A1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duf1348 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154293.1">
        <property type="nucleotide sequence ID" value="XM_018304869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1A1"/>
    <dbReference type="GeneID" id="28868976"/>
    <dbReference type="KEGG" id="chig:CH63R_09895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09895"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="178" mass="21354" checksum="930FCF371AEB2D33" modified="2016-11-02" version="1">MSSQEEPRPPFPPFTEATAKAKVKAAQDAWNTKRVKLAYTTDSIWRNRDTFLKGRDNIEQWLTTKWKRENGYRLRKELFAFTDNKVRTWFFMPKLLAIAARLEARLIVDQIAVQFWYEWHDESGQWWRTYGLEDWTFAENGLMGKRQMSGNDVKIEETQRWFRDGVDVNEVVISEEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y248</accession>
    <name>A0A1B7Y248_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154611.1">
        <property type="nucleotide sequence ID" value="XM_018305187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y248"/>
    <dbReference type="GeneID" id="28869294"/>
    <dbReference type="KEGG" id="chig:CH63R_10213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10213"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="151" mass="15619" checksum="7C046C1D54A8C4CA" modified="2016-11-02" version="1">MTDGNMLQPSNLPTAWVPVDGSRFPVSSKTARCVCRVGASAAATPPVGTAGRRTSATAVPGGSGLVTNVPACVRRQSSVASPRQLSVGGTKFGLCPSAATFRHLGRNFLHGGRRLLPCVAQADVELPKQGSRTPITIRDKPAGAPHVAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y284</accession>
    <name>A0A1B7Y284_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154630.1">
        <property type="nucleotide sequence ID" value="XM_018305206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y284"/>
    <dbReference type="GeneID" id="28869313"/>
    <dbReference type="KEGG" id="chig:CH63R_10232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10232"/>
    <dbReference type="OrthoDB" id="4587086at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="401" mass="45854" checksum="5A61D6872DB9FFD4" modified="2016-11-02" version="1">MLKEVSMAAKEYAPAAVDRKTAYNVPRPRFLHISPKFEGFKFEDYLPPNDEATESIYKQPFDPNRDFAKEYDVSDDEGDPASGRISPCTFRLLAEGCAKKDPKENQVYMADDAVRMRPPSPLEDSQGHVEVDRLAVTFELQRDINDGGWITPCYSVDTEPSIIYCPPGVNLKRKMRNWWFGLFDRMDPIAARNFRKIEFREANDSIAPLETVTEHSVPSTTSSERRHAYTDVEVLEALHAPGSRRVAGVAPQNAQLIISQRWQTVTRWKAQDAELARENDGMRGAIERAKMELREIRLTVDHLLQKKAAEELAMRQRKHNRVLRRVSAHLHELRYEIQSKLDALKSAQAQNYTMKAELAVLQAQIQEECSRADMASPDEVRRAVSQDFRDKIAAMELADCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y296</accession>
    <name>A0A1B7Y296_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154646.1">
        <property type="nucleotide sequence ID" value="XM_018305222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y296"/>
    <dbReference type="GeneID" id="28869329"/>
    <dbReference type="KEGG" id="chig:CH63R_10248"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10248"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="257" mass="28350" checksum="7CD14CD36C547AD5" modified="2016-11-02" version="1">MACIFRRTTLAATSSLNSLLSPSTSLTNRMKTTAPRTIYRNLHHRAFPTTARYTISSIASTPQSDFPSNNNFRARPRHRQSLSKFSSIPHLQMSDADYAAFLDKANQDPNEGYAKPTGNKSNEFKAQDQGVEVPKAIQDVLKQDKVYVSDADEPFVGVALAWDEAGKGLPDEVEFAQLIEHPDAENAGVELLDPVDWDSNGDYKDIFEAVRKAGKGNDVRVYKVPKGGVRTEYWLVTTDGKGKQAKLVGVKALSIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3E3</accession>
    <name>A0A1B7Y3E3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155049.1">
        <property type="nucleotide sequence ID" value="XM_018305625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3E3"/>
    <dbReference type="GeneID" id="28869732"/>
    <dbReference type="KEGG" id="chig:CH63R_10651"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10651"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="421" mass="45929" checksum="D20978A018683117" modified="2016-11-02" version="1">MDVCRSPPQQAPEATSFAANKLSVQSYRRSCDRCHVQKLKCSRNTRSPTQCQRCERAGHKCVYSQRNPRQSTRVKGNASSAARGGAGQSHQLPVPAGGDDASSDKLSPEWPGTLDGDAVDLLQEWTWQDFTGGPLGEYHDLLGQTLYSPQTTSTTPLSVKDGITTATTSEQQDVFERLSSISKTLEDYVHFLANQWDRKEIQNYPIGEVFGTFQAFLTTLQVQKPIEKPGVLEGCQHTRTVLLASHCYTVCVKIMEALAETLCQDMSAQASQNALRQPPGDVISASGSEVDFLVGESFSHLHPLASSLVSACTTLHTGVGILCKVEVELGVPWGNSIMAREALPAEGDGDALFPSQKRKGSAGFTQAARFLGVMREGAGSDFGYISNLQNFHRHHAEILRLTRQHTVCFLSKILSPQTTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y477</accession>
    <name>A0A1B7Y477_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Secretory lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155349.1">
        <property type="nucleotide sequence ID" value="XM_018305925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y477"/>
    <dbReference type="GeneID" id="28870032"/>
    <dbReference type="KEGG" id="chig:CH63R_10951"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10951"/>
    <dbReference type="OrthoDB" id="5382058at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601306" evidence="1">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="144"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="473" mass="51042" checksum="11A251DAF266F8DC" modified="2016-11-02" version="1">MRPFIILAAALLGAVNALDPICDAECQKGCDEACQAAIQTTYEAESALWVGDIVSDPFYSTPANSTGAKPGDILRWEDVPAEQLTSNWTIPAGLSLSRLLYVTEDVDRKPIPASAWVLLPFHNPFAKPGGGGGGAEQNKLRTVVWTHGTAGRSRLCAPTNNKGLYYDWKAPFILAESGYAVIAPDYAGQGSDIPQGFMYESGWLHVADVAYSLVAARKAIGDLLGSKWVVYGHSEGGMTAWRTNERLAQPGQEALLAAGEFLGSVAAAPALRPQKLIPASLTRAQGQPARDPFSVYFLQSLAALFPDQIKVADYLGEVPLQRLGALDKSCFQSGFAIVGGFTPEQLYRNTSWLTHPVTDDWAVRYNGQGPHSVKAPMLVISGEDDTITPNDLTLDDFNKTCAAFPGSSIHARVYPDMGHGQVLEAARADIAAWIDARFEGVPVPEGCVKEDVETITKRYATRDIFWHGSVVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4N4</accession>
    <name>A0A1B7Y4N4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_08465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155462.1">
        <property type="nucleotide sequence ID" value="XM_018303439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4N4"/>
    <dbReference type="GeneID" id="28867546"/>
    <dbReference type="KEGG" id="chig:CH63R_08465"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08465"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="877"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="925" mass="99886" checksum="C78970023ABAB76E" modified="2016-11-02" version="1">MSTLENYYEIVEPYLGHGNKTGDRQYLAHILETWNPNLDPDNDIGWALHWSIFQGDDAAVQMMLDAGVDPNTRDKQDPGFTPLLAASQHGKLETARLFWERVGPGGRFIPKKSGRSGPDCLQIAARNNHAGLTTYFLGAWDGWNDDEKRRALLDAASAWCDDAVTVLLTHPGISYSPEDIQDALVRAVGKRIILPEHETKPAPATADAVRQQQLVSRLVDAGGNPDSEDQRSHQPLIHATILSHECIGGLKGLLEKGANPNRPDSHGKTALHYLFSPLSRQLPATTALELLLLHGALPELADEAGETPLHAAAKTGTYEQLRLCLSHCRAPKAETIQLRNSYGESLLHYAAVGGQRTTVEFLLNSGLDANVASSNGWTPLLCALSPTALKTAHEMCLTNNFLLQNGAGAGVVTDEGWTALHAMGSWPAARDSKIRAEVANLAKRLIESGAPVGVKSRVIRSLSTTAVTLCNVWGFRMRDFVQRAIPSARDLGQTDMTTPLAWARRCSSTDVLDVLRTSSASADVPSLLKLFVFPFAISFQASCHGSRPSRKGVSRGEVVLRSVNQEIDGLRDDSPCRVTHAAAQEQSRVIGIDILVPTDVDRGATLGGQVQPPRGEIAIIKQHPAPPLEPLEEGLVGRQLVTRQRRHGPNIPQLLVGTPEPVPRRRRVLHAPGLAGLRVRVVAVEHLHQLDLVTAKVFCDTAEARLAAADVEGACFGLSPFGIIPSSIARAPIPSVTAFTKRLLALFYQKQKALSHLPAIIRPGTTDSVLGTASNRTQLCGAAFGGLLKRQLQERDKRKEKEKEFGHNEGANSKSNDRSVHLRHLSNGELFDAIVIGGAATPPTTTTTKPPVTTTAPGNGVATPQPTQPGMVNNCKKFHYVSEGNTCGQIISYNGITLANFVKWNSGVGATCQNMRAKTYVCVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4X9</accession>
    <name>A0A1B7Y4X9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155610.1">
        <property type="nucleotide sequence ID" value="XM_018303587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4X9"/>
    <dbReference type="GeneID" id="28867694"/>
    <dbReference type="KEGG" id="chig:CH63R_08613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08613"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="19351" checksum="91368903639B4412" modified="2016-11-02" version="1">MPRTRRPKLATEAEARQDEFKKAEALVNGKAEFKEAFTYHNRNKKRIAEVEADEKKAEEAQKKVAVKAAEAAKAIAFINGKAALLAKVDNQDKEEFKEAFAYHNQKKKRIAEDEVAEAAKAVAFINGKAFYVSRKAEGHEKKEFKEVLPPGFRSLGRDPRPAARRGPVKDGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5E2</accession>
    <name>A0A1B7Y5E2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155787.1">
        <property type="nucleotide sequence ID" value="XM_018303764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5E2"/>
    <dbReference type="GeneID" id="28867871"/>
    <dbReference type="KEGG" id="chig:CH63R_08790"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08790"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="268" mass="29956" checksum="D2DB74B305AE406A" modified="2016-11-02" version="1">MDDFFRPPIVLIHGLWMTPLSWERWVPFFQKRGFEVHAPGWPGVDGRTEEEIRSDPKPLAPHRIQDIVDHYEAYIRKLPEAPIIIGHSFGGLFAQILLSRGVGALGVAVCPAQPAGIVYISPSTVRAAMPVFAHPLHSDATVPISESHFRYCFGNLLSAAESKAQWARYCIPADSRVLWQLATSVTAGQAAPNYVRFDKPDRAPLLLIAASKDHIVTARTVKEEYKAYKGRAVVQFKEFEGHSHGLLFQDGWEDVASYVLEFIESHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8D5</accession>
    <name>A0A1B7Y8D5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156851.1">
        <property type="nucleotide sequence ID" value="XM_018302073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8D5"/>
    <dbReference type="GeneID" id="28866180"/>
    <dbReference type="KEGG" id="chig:CH63R_07098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07098"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="166" mass="18296" checksum="8B702B81CC299464" modified="2016-11-02" version="1">MMPSLCSLCRPSFSFAATYAADAAPSMARCGISTTMDGKIKRITERDDGKVMVFEVAATCIDDEDRMQSRQFRGLARILNTDKMKYGGDMYDVFDMKVAVFFDACSKVGIKQPHRIPSRSIANDEIVPLFAKSYTCANKNDSNLRFRNMPSVVSGASTRGKGSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8T3</accession>
    <name>A0A1B7Y8T3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157001.1">
        <property type="nucleotide sequence ID" value="XM_018302223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8T3"/>
    <dbReference type="GeneID" id="28866330"/>
    <dbReference type="KEGG" id="chig:CH63R_07248"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07248"/>
    <dbReference type="OrthoDB" id="3506470at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="870" mass="93655" checksum="E5A913F32744151C" modified="2016-11-02" version="1">MASPRSLSVVSVVNPGPEHNAVAQRTAPSLAPSKLPTLPYCSVLLHSLPTDMGNSGVHSHWSMLYPSGSNSSSSSSSSYSSSSRSRRSSSHSSGSGSGSGSSFSLPPITCHPVPSSSLPRTQFKPRRHHYYYYRHHNLHQQQQQHLSLPPQTEAAGHLCIRTGAMAEATEPTMDCNLPELLAQDLEFSSLIFAAKNMTAGAPPPALASDEDDWQSTAEPPTVLGATCHPNAVPQFQPLGAIDEKSSGSGASEHDISDNASSSSGDSFSMTGNDVDGDDHDDDDAAESPHIRQQSVMTAGTTISASSQPATAASSQKRVVSFGGEYEGSFDSWMDFEPDAPVDYPELGKSLAQSPVTTPVKPARPLSRLGDRSINESSPRRAKSANAAATTRRLSNPFEGYTRPASRARSMYSDPMTAAAKEQNRHSIHSLHSLTSLDMAVPTRISSLKHRVSFTDDARKAITSRSRSRSHASSTNVPDPVAVQGTNRSSVISDLKEELEPWFRYLDAQDEQPPGLSAGLAPPLLVTPRPASRSSASRIVTPTPRPRSQAQARSRPTSSLSTSYTWLEDPIDIPPPPSDDQSRRIPLPPNVMESLRVSVTCFPETMLLCSSLSIETIRSYSRKVRQPPLEALRPDTPPTSPKRWRWFSSRRTSNLANGGRRCCSRGSSSNLDLPSTMQPSTLTLTPPQWSRIRSIFPHGSDYLCDALYAHIVAYNYLAPMVHNPPTGGAGRPPTPGSPASTEDPIPKKAATLLGLQGCQETTTPKPLRKRSSMFLGLRASSWQSTFAAPPPSVPTTPLTAAPPPPASDIPLRDLQHGLHRCIARLVTTLRVEGSEGPIAGEPINDVDPLVMRSLCEIVKCCEESPTNDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA25</accession>
    <name>A0A1B7YA25_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157424.1">
        <property type="nucleotide sequence ID" value="XM_018302646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA25"/>
    <dbReference type="GeneID" id="28866753"/>
    <dbReference type="KEGG" id="chig:CH63R_07671"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07671"/>
    <dbReference type="OrthoDB" id="5244249at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="28695" checksum="FE4E117D658AF467" modified="2016-11-02" version="1">MSSMEGSCSGPRWTEHETNPAPEVMVHSAPEPVHIPMNVGNNSSNNGIPVEPDGDIAVPNDAERAVRLDSERRLRLWNWKIITGTCIGLIILAITIPVVVTVTATNRGRNGDNVETTAALSATSFPGPSITSSSYTTDPSPSSTLNPYQIANHLRMQAPECVRTKFIKSVTWIGIDQSMGGWDFNLHPARTAEECCTICHQSTHDGCNGWLYMPEKSFTPECSIIHGFSGPTKSDSCPNGRPGIVFAKTDDKDSYGGPGPCAGLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAI2</accession>
    <name>A0A1B7YAI2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157408.1">
        <property type="nucleotide sequence ID" value="XM_018302630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAI2"/>
    <dbReference type="GeneID" id="28866737"/>
    <dbReference type="KEGG" id="chig:CH63R_07655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07655"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="858" mass="94204" checksum="B8421E9AC9EACA76" modified="2016-11-02" version="1">MEEASGTQQQAQPGAGSDSSGGPPATSAPAPTSIPIPAPSVNSAPTPSVSGSSGAGQLSKRRRGLGVVTPNACTECRKKRAKCDGQKPCGRCKAQKDVECVYEIPVRQSKEHLRSEIEQLRHRQRSSDQVIAALVRSDMWEDVLQRLRGGQSLESVSEWLGGTLPSGGGSRTSLSRPTEHAGDANAGGSGARTGFPGSTPAPIRTRNVGGPGSVAMSPITGQSNLRQDIDPNSPWHLSSHSQSTRSNSHPDVMNWSADNNSNKPPQGLFDTWGESTSNTETSEGGSKYQGLDQVLAPLDLPDMKLPPEDWTNITDDGSLVQHLLALYFCWEYPTFASLSKEHFLRDFQNGVHRYCSPILVNALLALGCRFSSKSSTRANPNDPYTSGDHFFKEAQRLFYLQDNHHNLTTIQALGIMSIREASCGRDSESWYYAGQSIRLAIEMGLHQLEEDGDDDEFAVQAATFWGAFALDHAWSLATGSLPQCSCFPHLPPKPAIIDDIEASLWIPYTDDGKFLLSLQNTPSMPSAQGSTFPSGAPLQRSAEQPSNVRSVYKCFCELSELVHQSLYILHSPGRPLTSRDLLGIYTQYLNWYDRIPEVLRLGHNFTPAVLFAHMYYHFAILLLFRPLIKLRIIGSKLLPRDVCGQAADAIQGLLRSYSQLYTLRRTPSFVPYFVLTSSIMHLAIGAACAPQQKGFEATAQSNVDPPAQPPYPPRVVEAIKQGIRDLEEMAPCHHFAEQALNILRYLAKKWNIDVDMGEMVRSDAEYAHLVRPYTSSLNFFAPNVIEDDFICTWGGSTDETEMPNPETAMGAKGTEAEKPSVSRAAKVLENPLFWPFPMQGRPMLPTGRELEKAGFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBA8</accession>
    <name>A0A1B7YBA8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157869.1">
        <property type="nucleotide sequence ID" value="XM_018303091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBA8"/>
    <dbReference type="GeneID" id="28867198"/>
    <dbReference type="KEGG" id="chig:CH63R_08117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08117"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="169" mass="18432" checksum="58816B55355094D4" modified="2016-11-02" version="1">MKDDGRSRCKLAACPAGALGLATRSCVWRGHGSADRGASHFDLGKKRPFATAHRHESGGGLMPNRGTAGVGRWALGDVTGTHGLTYHPTVEKKHLLIRMAQLATHASRPATLIGRPDHELGPDLVTHPQPPIRTTGPPRPRPPASKDELRPTQCLYEMCRHKKHGRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YC45</accession>
    <name>A0A1B7YC45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158208.1">
        <property type="nucleotide sequence ID" value="XM_018300358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YC45"/>
    <dbReference type="GeneID" id="28864465"/>
    <dbReference type="KEGG" id="chig:CH63R_05383"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05383"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="160" mass="17734" checksum="0AF228E4F30D9A86" modified="2016-11-02" version="1">MAEAAASTEPPPWWAAFPAPKAKTPEIEADEVMVLLESQLAAGNDTARRDFLLVDVRRNDFEGGTIATSINLPAQSLYQTRPIIHQLCKQAGIKRVIFYCGSSNGRGPRSANWLQDYFDEVGETGIQSVILKGGIKGWVRKYGGRMMDTYDERAWVDVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCD7</accession>
    <name>A0A1B7YCD7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158246.1">
        <property type="nucleotide sequence ID" value="XM_018300396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCD7"/>
    <dbReference type="GeneID" id="28864503"/>
    <dbReference type="KEGG" id="chig:CH63R_05421"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05421"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="568" mass="65383" checksum="7BCC8E7E20C936ED" modified="2016-11-02" version="1">MLADALLLSMSTAYHLSNHPNKFDVTVIDSVDYCGGQAFSIPLDKDRHGASWFNQGVQGGSYIFHHTLTMFARQGYHADPVELQVSFGKDERFWTNVFPTGFLAKHQAEVRRLAFMLRFMRWFEVVFALLPLKLVFKLFFFSDEFTNVVGLPMTALFLGTGNATPEVPAIMLERLCTSPTYGMWYPVDEDSVVSNHPPMVVFPNFTDFYTAWKKDLESRGVTVRLSTELTEIVHRNKRGVLVKTKPRTPARDGHNPVDGDPDAPESEEHYDELVLCVLADTAKKVLGKTSSWRERRVLGSATFSDDITITHHDADYMKKYYENFYDEDKAVRVLGKNGDRDQSSRLEYARDNFRPMYYIRMYDGDLSKLEMSFDTTNYQSQFPDKVPFEQHVFQTIYLNKGRDRKHWTDGEIAEDKIIRADWWHQLCHSWTHYLLVVPWMMFLQARRRTRFAGSWTLVNAHEVAIMSGIAAAVDLGADYPEDLEHDRFAFLSFRLYYLLAYGRWYRRRFQGSGSQRAKDGAGWASGLYGSVYKGPGVATEERSTWREEVKAGRSTENLADGNNGRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCV8</accession>
    <name>A0A1B7YCV8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158438.1">
        <property type="nucleotide sequence ID" value="XM_018300588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCV8"/>
    <dbReference type="GeneID" id="28864695"/>
    <dbReference type="KEGG" id="chig:CH63R_05613"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05613"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="327" mass="36062" checksum="606B193484AF111F" modified="2016-11-02" version="1">MKSIGIFPGSGALGGCTYDYLLKLLPADHIILINRHPEKVPQEHIKNGVRARKASYESSPSDLEAVFSGIEVLFLISYPSHVHDYRKKVQLPAIDAARRAGVKHIFYSSLAFAGDLEDSSVAEVMQAHLDSERYLAEAAASDPGFTYTSVREGLYSESYPIYTAFFDITAPPPSTTTTTTTTTDEILIPHDGSGPGVAWVKRAELAEATAKLISQYSWDPDQFPHVNDKVLLTGPRVWSLAETVEVLGRAAGRDVRIRRVDVDEYARLPQVVARFGSREKARTWATAWEAIAKGETAVVTDTLREVIGRDPEEFDVTIKRLGQARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDJ8</accession>
    <name>A0A1B7YDJ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158680.1">
        <property type="nucleotide sequence ID" value="XM_018300830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDJ8"/>
    <dbReference type="GeneID" id="28864937"/>
    <dbReference type="KEGG" id="chig:CH63R_05855"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05855"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="250" mass="27073" checksum="3FA81E081CBC7DB6" modified="2016-11-02" version="1">MSKLGVSKHHGLEDSPALPTDACLASHPSAGQHQSRSQKSEVQPQRALGTWTPTLQGFLLFLLPPFLQRGTYLTYLYAALAPGDVHLVPTRVKYSNPESNNCCKPPRPSSALQGLEHTIVELNSALELSCTTSPRPRPRLPSFTPSIPSNIEEKESQNKAIRPLSICPGAFEQGQPESVPSPASAANLGLRHPADPEDVNLTGRDDGMAISGGYYTLAIRHCPSSRLSSPTRVRVREHPDQKTLTWSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEY1</accession>
    <name>A0A1B7YEY1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159093.1">
        <property type="nucleotide sequence ID" value="XM_018301243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEY1"/>
    <dbReference type="GeneID" id="28865350"/>
    <dbReference type="KEGG" id="chig:CH63R_06268"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06268"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="370" mass="42085" checksum="5602130C294CA405" modified="2016-11-02" version="1">MAETNSNNIDPNEVDREIEIAAEEVTRQCPLFPSLLLRVADLFQQDYGDNVSNIGSTVASSTTSVWSSILDHRIENGRTYHRYKEGNLQHHLFRLTFEGRLGNAPPIEPDAKVGRVLDLGCGTGIWAIDYGDEHPETEVWNEFFCAENLPQFSHVYQVLGIDLSPTQPEFTASNVMFEIDDVEEPWTYTEPFDYIHSRMMNSNIGDWDAYVKQCFDNLSPGGYLELNECDIAPCSDDGTLRADSAISKSVQLLQEASEIFGRPFKPMKELKSVLINAGFVDVVMQQYKWPTNDWPLDPRFKVIGSWSNDNISSGWEAVCMANLTRAHGWTREEVIVFMAQCRKEFSDRRIHAYLSIWSVYGRKPLASNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEZ6</accession>
    <name>A0A1B7YEZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_06192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159017.1">
        <property type="nucleotide sequence ID" value="XM_018301167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEZ6"/>
    <dbReference type="GeneID" id="28865274"/>
    <dbReference type="KEGG" id="chig:CH63R_06192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06192"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="120"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="523"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="588" mass="64513" checksum="30F4B155530EE733" modified="2016-11-02" version="1">MLILYYDGLLRRCVDFFPPVTPCTSSRLTLGPYQDGTAEDVSALIKDGEVDDDDDDDDGENDDDAYEKWWAESLESLNRIRKRAVVRQNKAPTALVVISQPPRVDIKELKSYSYDESAGTGVTVYVVDHGYYTRNSEYTRMAVPPRWIFAGSQSQKQVREDLHRHGHGSCVGSKVNGPKYGTAKNVNLVIVKAATVAWETDDALRRVLEDVKRRKLQGKAVISLARGRHDEAASEELKKLTNELIQNDVVIVASSGNDFRDAVERGLVPAREINHWPALMAGQGVPIINVGAVDNTGKNASFSQGGPLVHVMAPGVGVRCASNSFFFRSQRVDGTSFASPAVAGLAAYLLALGKHPELRQTGRVAANMKELLIEMSYRRSTGGGLVVYNGQAAPRSRFRGAKGSCVAPTPGMFLGGVFPSKAGSFRPGLGAPSTRGFPVLTSSTPKSFHTSEAPVRIRKLSSGPAHSAFASSSDVVDSLSKLAGPMPLKTPLWSFVRSYSNGPARSRLGKKALSLDHFLQRSRAISLYREIIRGTRRIADPNTRTESRRFARDEFERHRDVTDLGHIRYLISTGKTEWQGMERYVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF36</accession>
    <name>A0A1B7YF36_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethanolamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159057.1">
        <property type="nucleotide sequence ID" value="XM_018301207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF36"/>
    <dbReference type="GeneID" id="28865314"/>
    <dbReference type="KEGG" id="chig:CH63R_06232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06232"/>
    <dbReference type="OrthoDB" id="4419870at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="149" mass="16266" checksum="18DCF79A18B7AB36" modified="2016-11-02" version="1">MADSASVAFIMSEPIVPLNIIKGAGHEFIPLPEGENATVADFHSIRTKTTSSPAHFTSGFYKIVAGPSRPAHYTFEETKYVLSGQIDILDEATGITHHLVPGDFAFFHVGSKVKFSTKSEGLAFYAVTRPVRVPHPNLQGREEDVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF79</accession>
    <name>A0A1B7YF79_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_06246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159071.1">
        <property type="nucleotide sequence ID" value="XM_018301221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF79"/>
    <dbReference type="GeneID" id="28865328"/>
    <dbReference type="KEGG" id="chig:CH63R_06246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06246"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="8">
        <location>
            <begin position="180"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="779"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="861" mass="94799" checksum="C46E33F3476C72C8" modified="2016-11-02" version="1">MEFYQKLRTSLDSIASSGSELLRQSENGSNGASPYEDKSEAIHHPRKRLMESAMKLLHLVTMPEEYLDHLANGYQELTCVRWLVDLSVLQHLPQEGSIAYPVLAAKADVPEKHLKGVARMAVLNGFLEEPTSGHVAHSRPSALLVRDENFMSWARWMMDYSMPVAYKFAEATRWWGDTDAKNQTAFNVAENTTDPFFDHIRKNPDLTAVFSSYMRSVTASRPWSLAHAVECFDWASLPEGAKVVDVGGSHGQLAVEIASKFPHLKFIVQDLPETVETAQRAFEADTGIEPGVKSHIHFMSSDIFKPQTVLDAHVYFLRMIIHDWPDRDARVILQNLRAALEANPRARIVIMDTVLPPPGSTALQHEQQLRVRDLMMMQVFNARERELENWKALLNDVGMEIDHLRQPDDSVMGLLTVQLQSSAPGSPSEFVQIKKLIMPATDDRPVLIMGAGISGLCLAQALKRHKIPFRVFERDAAVDSRPQGYRLKLREDAAVALAESLPGEVYQTFQTSCANLAVGETDFNPFTGLVVNSRSGGGLSGKLGLHPSYCVDRAAFRTTLMSGIEDCMQFSKELTSYKTDEDRGVVSAMFKDGGSAEGRFLVGADGLHSVVRRNLVPTHKIKDTGAACIYGKTPMSPDVLAKFPEKGMRWMTIVSDQTPMLQSCIIGDAPVTLLLEPIRFSEVSRSQHQLPADYIYWALIGPEARFRPDGEASTSKVSSSASAQAATEAARLSLSITQEWHPSIRSVLEQQDTSQATLIRVVSSVPDVPSWPPSAMATLLGDAIHPMSPCGGVGAQTAICDACSLAKTIAAAQGSPTAEEIGIFEEAMRARARRSILQSEMGSKKMFGLRSLEDCGAWTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGA6</accession>
    <name>A0A1B7YGA6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159616.1">
        <property type="nucleotide sequence ID" value="XM_018301766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGA6"/>
    <dbReference type="GeneID" id="28865873"/>
    <dbReference type="KEGG" id="chig:CH63R_06791"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06791"/>
    <dbReference type="OrthoDB" id="4831252at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="195" mass="22334" checksum="9C98EE66BA082F36" modified="2016-11-02" version="1">MARAKGKSKRRAKGKGKKKASEKKCKASSAAYHPATVSAGLGRVSPCDPMRCSKCRKVRTRLWNTRYQANDPYNFKLNGLQAWASCNHCVWRQSTLSAEDWVELHTPWLFDGYCPCHWFEFDDHYYGYCPTTKRMFGSRKRREEVEAAVAKEKKEGSEEDPAAAASDEEEGDEMDIDLEADDQQRLVQEVAEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHX4</accession>
    <name>A0A1B7YHX4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160204.1">
        <property type="nucleotide sequence ID" value="XM_018298958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHX4"/>
    <dbReference type="GeneID" id="28863065"/>
    <dbReference type="KEGG" id="chig:CH63R_03983"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03983"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01252">
        <property type="entry name" value="acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="241" mass="26059" checksum="A864D3B751CFFDF3" modified="2016-11-02" version="1">MAVNEIFQYSIISALMDGVASTGLPVSQLIAHGDHGLGTFRHMVGEMIILDGKLYQMKSDNTVHPVDTSPASDAVAPFAMVTRLRPTATVRAAFADKKQLFEHLSREFPDSKNFFLAIRIEGVFKGITVRTAGGQSRPGEGLVEVGRNQASHTFEEPVRGTVIGFRSPEYTMGISVAGDHLHFITEDRTQGGHILSFGTDGEVDIGAAQISKWHLELPTNDPEFSRAPLEGDKEGIAAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIU3</accession>
    <name>A0A1B7YIU3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_04293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160514.1">
        <property type="nucleotide sequence ID" value="XM_018299268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIU3"/>
    <dbReference type="GeneID" id="28863375"/>
    <dbReference type="KEGG" id="chig:CH63R_04293"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04293"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="850" mass="93161" checksum="B3E5A15785E18C0F" modified="2016-11-02" version="1">MTAPITQQQSAQAKDAAAAASVRKRRRRAPAGGAADDCFTCSKRSVKCDRRRPYCSQCLEIGNECSGYKTQLTWGVGVASRGKLRGLSLPIAKAPPVAGVAKKSPVRPRANSTATTAGWADADNVSRRNKRDDAGFSPEHVVSTPTTPFPHSYDLLSMSHPEHTPSLTAGHWGGLPYANSMPTDGPNYRKLGAHLGPIPISGAMSSSLDSVSDADYMSPISHSYSRDDIPFLHSPNVMYDGYSTHGSPVPQSPISAILIDQRGAPTSCPSLVYAPSEHSSSLTSHMDNFESVPEMDAYSNSCNSNSHVWTSPPPESMSPHHSDHHQASAQWPTMFEPQAVHVNPDLIAKMPFFMDYYKNIMCPSMVFMDGPGNPYREHILHLASNSQSLQHAICALSACNLRMKRRLSLGQDTRELSEKLMAEKSTAESMADAQPEDQSLSEEYQHRNLAVHLLNQQLNDPAKSSHDSVLATILLLCHYRMVESGIAKFHTQFAGVKKILSIRRSQNLAPSRDSAWMEAIFTYFDAISASINDREAQLNSTFYGVMPDAQLLPPGAENLVGCDRELFKTISKLGRLNLLSQHRAVQNLVGGPGGRNVPSRSQSPLGSPLGHAYKGSIGGLHQQQQMGDAFNMPMRFDGNGFGSTLDDDEFASSSLCSSATYDDHRNNFWREWKEARVALQSWEFDSARVHASLPSPATPAQVRDLGSLSEAFRYAALLYTERLASPNVPSTHSNFQNLVSQVVYYATSLEAAGGQAEKFLLWPLFVAGSECVNGLQQNIVRSKCRDIMARSGYMNNLAALDVLERLWAGEWKDGEPRSPAAVKLEAMRRGPFNWTRCIGGPGVEVEWIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIX3</accession>
    <name>A0A1B7YIX3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_04246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160467.1">
        <property type="nucleotide sequence ID" value="XM_018299221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIX3"/>
    <dbReference type="GeneID" id="28863328"/>
    <dbReference type="KEGG" id="chig:CH63R_04246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04246"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="445" mass="50136" checksum="89D01AC0E7BCCCEF" modified="2016-11-02" version="1">MLLFLLKVFLLAALLVGAVYYFFLLPPKYPQNIPAIPFWVTLIPFFKDVDQSDIFRDYIDQPLRTHGAVKIFFGAQWNVLVHRPSYLVEIFRDEDLYEKSGNQKKIPHSVLAEFLGRHPQTRHLLARESLLTSKPGDNVISARGDVWKNYRAVIKPGLQRNVDVDVIENNAVGLCRLLRESQQRAGRGGVAVQDLLQRYSVSNFTEAVLGTTLHALDRADAPINLLQTAVKKEIFKPIFMSFPFLDRLPLKSRLAARRTVGLFKNELKRGLQASHYLHKPAEKASLSDPSDMLGKRMLDARASGQWDEKQLLDNLTVAFVAGQENPQLAMISSLYLLAKHPEAQEALRQEIISKGAKSAADLAKEDMPYLTSLIYECLRLFPPIGQLINRKAAETAVLGGDVVIPKGTWGCSSEAIQQNYRRRRARGEWISFHGGEEKSHVLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJN0</accession>
    <name>A0A1B7YJN0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160621.1">
        <property type="nucleotide sequence ID" value="XM_018299375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJN0"/>
    <dbReference type="GeneID" id="28863482"/>
    <dbReference type="KEGG" id="chig:CH63R_04400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04400"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="82456" checksum="E336281C2DB0BE59" modified="2016-11-02" version="1">MAETRYQVPTTGIETYLTHPILEYEHRHSGRLKYASPRDLPSFPSPGLPPDGAAAGAAASLGWANQKSIQLWKPEKSNSASTAAMLAKDYKMPPTWEPNSSSAGAKAALVASASARKQAASQMTPQSAHGSWGSSAANQAFKQSRAVKQPAHKTSTGGLGSLLAAQSAMPATARTRPRAKSTPVPKESYPGESRAAANALSAATAAHDPSTKPKSPTDTAGSVPYTNLPRKMFTSSPAIGPEADEQKRADMLHASAVAMARQMYSHQQKMVDQARQAQQDSGEAVSDDNQPKPYVNLQEAAYKLAQERLSKLHEEHQRNRDYQEYYGNGKPPQPQRRFTMKGKLRRRSSSDGDINDDREQSERIRRQMSIFSSNLTKVDEQKRTKDREALLAAAQRNVRARLQGMDDKISAETGMVPPSSKSDWEAKAQMAALARHESANVNRGKIDIGGGMFMDPAAVDEIATRRVQPVLDEINEKAAIERERQELLKAEAEAKKRDEAKQKERDREIKELNRKVMEQEKQEEKERRHREKKELKAKKDEEKAARAEEKRKSKGPETLPDESPAAGESSETSPTVDGPGTSVSRRASQGKPTVNTQREASNSDNPRSPSESGSPTNKMKEWLKSRFSRPRGRSSAGENAEDRGFVGGVALTRLANESATSLDGRSASMREVAIAGKTRVEVSNSSAGYEDSGHKARNSRDVSPVSSDSESEHFVEARDDLEGPVSPPVPIRDPGLHKSSSPTRDSRFREIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJV2</accession>
    <name>A0A1B7YJV2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_04649</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160870.1">
        <property type="nucleotide sequence ID" value="XM_018299624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJV2"/>
    <dbReference type="GeneID" id="28863731"/>
    <dbReference type="KEGG" id="chig:CH63R_04649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04649"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="399" mass="43650" checksum="426088F0396E287E" modified="2016-11-02" version="1">MEQITRASWPTLVVALLSLAAIGLLTIFVTLHLIAPKPRAVLPSEKVYLTSSASGNPIKISAPCWFDRWFAERSVSEARAHLTDPRDIPDSGATIDPADVRLTVVLPAYNEETRILPTLEEAVAYLDENFGRPSSPSKPLLSPTAPRRRAKNPPSESLSGYEILVVDDGSRDRTVDVCLEFAQKRGLHDVIRIVKLERNRGKGGAVTHGFRHARGEYVLFADADGATKFSDLGRLIQGCEDVVDGSHRGVAIGSRAHLVGSEAVVKRSALRNFLMRSFHLVLMILTPPATSRLRDTQCGFKLFTRAALPHIIPYMHAEGWIFDIEMLLLAESAPPAPVFGDDGSVIGTSPGIRVAEVPVDWHEVPGSKLSVISDSIKMAIGLAVLRGSWMMGVYRRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLF1</accession>
    <name>A0A1B7YLF1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_05152</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161373.1">
        <property type="nucleotide sequence ID" value="XM_018300127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLF1"/>
    <dbReference type="GeneID" id="28864234"/>
    <dbReference type="KEGG" id="chig:CH63R_05152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05152"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="296"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="599" mass="66537" checksum="734A545DAAB7C8E9" modified="2016-11-02" version="1">MSLPWLSQPVMLHSSRDAGTCSMTPEQCAFKTGYWVFWYEADHRYGLPTVALFLAVILLVAVGSFAATYAPKSLRRRPLWSRLVSLGRLMAYKNWRLGSWNSQSLGTYVLGVIGAVFFFAMTLGPQPYYWPNTRKLSFGNSPPIATRAGYMALACMPFLFVLGAKANPISALTGISHEKLNIWHNWVAWAMFVLALVHTFPFIVFHVWKGDIVMQWNDGGTWVTGVVALLAQAWLTIMSIRWIRDRYYEFFKATHLLAAAVFFVFFFIHCDFRLTSWDYFIATAVLYSLCFFYAQARTFMEHGVRRARLSLITPSCLMVVVETDTRWTPGQHVYLRFLTAGIHALTAHPFTICSVPRRGEKSEMVFYVQPRKGVTGRLARIAAKAPGISVPVLLDGPYGGVTARWFSGFDRTLVVAGGAGAGFSLPIIEHFLQSSRNNKSESEMTVVIATRDPNFREWYCEALESAVVRQQNASDTKSSRVFIHYHETECSVSNNPGSSEADTSIKAPTKSVEKEPGAGDADCWVSDSGSVSLQRAGGRPDILSLARRTMESEGSVGVLACGPASMVFDVGRAAAEGQRRILSGGSGASEVWFYNESFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLK9</accession>
    <name>A0A1B7YLK9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161446.1">
        <property type="nucleotide sequence ID" value="XM_018300200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLK9"/>
    <dbReference type="GeneID" id="28864307"/>
    <dbReference type="KEGG" id="chig:CH63R_05225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05225"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="88" mass="10052" checksum="61D7676B8DB7B6F4" modified="2016-11-02" version="1">MTDSNVVEEALYQETFVAHPWRRVQVGAGREAVAGSAPRPQIWGARWEENVTGSQIKHPFAYETVPRDFRRQDDESRLMPARWNGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMG9</accession>
    <name>A0A1B7YMG9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161750.1">
        <property type="nucleotide sequence ID" value="XM_018296934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMG9"/>
    <dbReference type="GeneID" id="28861041"/>
    <dbReference type="KEGG" id="chig:CH63R_01959"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01959"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="161" mass="17864" checksum="B133AFB7C3D040C9" modified="2016-11-02" version="1">MHFRTPSSGHLLDISTQDDPTDSATIFRGPPLVNRTPCLIVVSHKSSQDSRSSWTMPPAEQERSLKTNVDIACSVSRTCLPPSYEDPTRRVQAHHVFLSRSRGNPTAAAATCTSEMEGDGEVENPVWPVLLFTWQSGRRHGTDELQTHGSTALHYRQIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMS3</accession>
    <name>A0A1B7YMS3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gpi-anchored cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161741.1">
        <property type="nucleotide sequence ID" value="XM_018296925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861032"/>
    <dbReference type="KEGG" id="chig:CH63R_01950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01950"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1369" mass="146865" checksum="62686519A9F357A0" modified="2016-11-02" version="1">MSLNGLDDPKVKEAHEAAVAEPGGWFLLKYASRDDVELLGRGTGGIVEIRNNIAQFENENDDNAPLFGFLKYRRRNVIIKYLPDDCSRLVQARVTVHFNAVCERFAPYNTDFSIATAKDLKDTKLSAACSLHAASGSTSSSTSSLRRRRLMEIAEEEEEEQRASKRKSVGPDSLVETSGEDPADAPKSPIGGPPVTLNADLANSPEESKFSASLEPPEFVGARPSSPTKSVDEGRRMSSQSLRPELYSSSSYTYGKPRVKLAPRPSLDVSGRARAGTAAVGAAFRPISQMPSGFKLFSKGPKKGKSKENTLDPSEPAHPDETTEISLAATLTPLPDGDPISHIDELVRPHTSSGRPTTSSGASIKSAMPSFTTAPSTKQVMTPEKARLMKAMQLREKKKKMMNQQSATTPAVDAPAEQLMSEKAQPAQHVEEIAEHTLVAEADDGEEEEEEEDDDDDNEDDDRRLSVSKADSGIVVDASSVSVHTDVASEFTQSDSHPASPIMASSEPDHSTKASSLSESTDETVKESNEDNTDAEVDTHGTHDAVESATESGIAPAQAAEPASPVEAVAPTSAEPEAVDGEPQEEGESLAEGLAPAAVDDVPVVQFDATPEAVTAPEMSETQDTSTVEKEATLEVAEPVEQQQNETEKVAVMDEQQKPPISLPISKFSTSPTQAKPSIESKETQDRTSKQDIKAETTVSTTSEASPRSPLSPLSPCSPSLRVPRSKFSTQDLRAAANVEVPTIVSPPEDVPREPVAVAVDEPRDADAHSVDTEPSKRKALVEPIRTDLDPPKKAADGNISDDEDLMDELHSATVQQAQHITVSKSPITPVFPSPTQSASRPTSRGAVRTISNPVRGNLLTPADVAQAQNQRSVSSGAAFLHRITQQQGNQHLAPKQPGKIGSSISQRIKALEKLSAHAPGTVDADTSSLKAPRPSSAFFAVKRGASVREPPRSPSVVDRASSLTRGGSPVPSVMTESQESSPEAARANRGRSGSMANRLSMFEVPGSNPPRGQPESISVTARIVRDPSQSGRAPEPPKNPSEFERLDLKVSPLVVDHQKAEPLLPPANLTTVKPSKETIQERRLSKEKRRSQSVDPIPDGDEAPRRSSLSIMKDFIKDRRKSLTSPSAEALTAPLPMSPGSSKSPSRPPSTHHNSSGLGRRLSISSRRSSFSKDNDASGAMSPSLFTEGSGSGDDSKSTTSDKKKGRAGRFMRRLSSSLSSGARSKTMTPTAISPTVQEEDATEVARLQQPTIEAFMGDVNVQFPDNLLWKRRSMCMDSQGFLILSTVAASTTTKDKQPTGAGVKRYHLSDFRMPYIPDMEIQELPNSICLDFVEGSGLQVACEDRAGQMNVLHILQDAHQSHNSFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMT9</accession>
    <name>A0A1B7YMT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161771.1">
        <property type="nucleotide sequence ID" value="XM_018296955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMT9"/>
    <dbReference type="GeneID" id="28861062"/>
    <dbReference type="KEGG" id="chig:CH63R_01980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01980"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="449" mass="49047" checksum="3CE7CF1040EF6031" modified="2016-11-02" version="1">MGANVETGSAVERDNTKGGLEATEASNLEGNQPDSQTQSLVAECLPEVLERKLSVDKLPASVWIVAIAGAAERFAYYSLSAPLLDQYNRPGEAVIKVKGSKTHVADRALTIQFITNMFFWLTNLAALSSLASTWIEKEVDFWASYLMGFISLFVTVVLIYFLKRKLAWILKEVYCHCLSELYGALRDIASVWKPPLQIHREIGTFAECLELAKLAGLHASRLFSAPFYLAYIQIMNNLISQAGQMRLGGIPNDTMQVWNPVACIVLGPVIQRGLFPLLRRSGVPFGPIVRISAACFIMGAAMAYAAGVQHMIYSRGPCYSRPLQCPEAAVREGASSQGTLGNDISVWVQMPVWFILAVAEILGFATISEIAYEQAPKGMKSVVQAVTQLTAGLAAVLGIALSPITKDPTLVILYSVIAGLTVVAAFPFWFYFRALDHKKVEPDTNSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNM1</accession>
    <name>A0A1B7YNM1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162157.1">
        <property type="nucleotide sequence ID" value="XM_018297341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861448"/>
    <dbReference type="KEGG" id="chig:CH63R_02366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02366"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="9">
        <location>
            <begin position="432"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1495" mass="165508" checksum="7B88DFEC6AFCF00E" modified="2016-11-02" version="1">MDQPTDAISSLIMPLRSLICAISIKLLNPSRSIECLAEEAPEYRGDEDPYITAPAVLEQVHNAILAAANSDCESQSPIIFAWTVVVHRMFYSHHDRIEKRDALQNQRSQETFEAGVLIRPTTNRRLSAGSIVSLDGKSFDIFLNNVGLDKDLQVVEQLAVAVTSNGRAYEVLSEMALAIGGYSDGAFSPLLGSRVRLAYVDFLKATYPLVGYQSDSVTSLLSVLGAGQQYWDLSRPALHPSNDILAEVLQDSTAMEYYFHQALNRYPFELLPFLNICRTLANCVVADDRMDTVVNLLRKTPSLTFILPDDYQQYELAQEEDNTNTFYLLEDIPLFTPATAWNRRTRLDDAFRIPAETVGRFVTDTGRVVLMEYEHSALALLGKRLEVQLAPETYRSELDAFQPEETAETIALFATLLRAEVLKSERQGLSGETSLKSGLDLLEEIGKHVSGNKDLVAVVCETMDAYMQDEKATEGQGIAVINSCVQFLHAILPLCPTRVWSYLARCELLNSEAQAGKLAKITGNLDLVGDRYDLLLSAVRLFASLIDSVKSSAVQRKSGNKLVGRQKVSNNVWLGVADKVLGKVSLAIAQATVDVFETSSTWRFGSELYKTLLIRHVVPVMDHIVLYTYGMGDQESSETLTACLEPAASYIIDAFLSPSTGSLRFQPLLTTLVNGLQVPDSTFYQERLASAQEQLISALRFTTTLLRVANHLERSSEIFEDHLFKTSSILARLCAICEQFRRPALLLLEALVLSAARAHDDPPSLLGYLGPLLSRSFIQVLSQLDKPFLVAEDVQTTWKFFSTIVQNRQQWLSNCLLTGKTPRDALKGAKKDTSSTPNSVLATAFAKLKDIKELDITEALRILDFVASSQNHWPWTIFTMQKDSSFLDSLRLYVKDLSSFTVTSKADAVKAAIDAKMAAYIAEIFAMQLYHLRQMGGADVFAKSLVADLDYYLRDGVEVSSYNNSLHSNFAKNFTSKYPGVSLEAFKRTMLRPGELGRSYFYDLESATEMLSFDPGWHGRRDNGFRNEMGIANANLSLVDAQISLFHAWEFLLLELSSSLPDNDNIAKQMLQVAQQCLEANRSNQGPENIFMRIVEERADLSLLLIQRLVGRPISSQDVNQLLGTLFTIISAVEEPFNPGSISYYRTILKTIYVTLRAYSVADKKGLGASKSGGEGFSVTLTQTVLNLLDRVVAKGFRTLVALVHDPEAAVAPEDLALLTAILQACLNMPTIDQCQTQILNIMASYDAMHAATSLFSWADKLAINGDPIYGELSLLFLLELSTLPAVAEQMACDGLLSHLTSAGITNFMRRGNISPFSEAIGPQRCYSMWVKGVLPLLLNLLTALGGTVAPELGYVLNQFPLLLKSSVDRFEAPGASRTASREAPHYVTLLSVSEVHSLALLTRVIAALRTANTRDIPEIQWDASSLLENIDFWLSSRKLLRDRLLPLGQREVEWKSTKIGTPDEGGHLGNALENKVLSQLEAVRDVLSEDLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPJ1</accession>
    <name>A0A1B7YPJ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH63R_02703</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162494.1">
        <property type="nucleotide sequence ID" value="XM_018297678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPJ1"/>
    <dbReference type="GeneID" id="28861785"/>
    <dbReference type="KEGG" id="chig:CH63R_02703"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02703"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="176"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="747"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="951" mass="106994" checksum="C711B18701AE26AC" modified="2016-11-02" version="1">MEDEALATVKMEEAKIDVGIAPHSVKMERDASRTSSHNKSNQGSRTTSMSPVEDTTNGEDTSTPGGTLRPKLSRKTSQKPVKRESPLFHDLPDVTEQSCNTFQVIPDCLYGSKHMGSTDNDALDCDCRSEWHDGKNLSCGEDSDCINRATKMECVAGAGNCGDGCQNQRFQRKEYANVSVIKTEKKGFGLRADVDLQANDFIFEYIGEVINEPTFRRRMVQYDDEGIKHFYFMSLTKHEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGEKLRMGIFSSRRIKAGEELVFNYNVDRYGADPQPCYCGEPNCTGFIGGKTQTERATKLPLTTVEALGIDDGDSWDIAVAKKPRKKKPDEDDEEYVNSVQAKSLDDDGARKVMATLMQCKEKWIAVKLLERIQQCRDERVIHSVMRMHAYQILKTTLNTFIDDHNVVLQVLDILDKFPRLTRNKIEGSKIEATIDGLTHSEHEEVSAKSKRLLDEWSKLELGYRIGKRKFDPNASATNSFQERRNMDREEDLTAKSTPDPLQNIEIPKGPRSNIPQRNTPFFNGPPRQRRHQNFNNNNTNNGALPAGWFTATDQRGNTYFYSKNGATTWQRPTKPADAHKSTPKALQEQQLLKNIIDQVTKEQTPKHSASQTPQRAETPVQETKQEKWRFLSTDKQMKIYENTLFPHVKYVIDKYRHKLPKDDLKRLGKDVCKKLVSSDYKGKRVQDPTTPLDQKQARKVKTYVKDFLDKAIVKFKQFEQEKEKASPAGGADKPTDGATTSNGPSVDTADVATPADVADEVMLSDIEDAGLMGSPDRKRKRGGEEAAESLNLTPSDEPSVKRLREDDVEDGPTPPPPPPPPPADLESTATPEEPMTEEQKALREQEEALMRENEESERLEEEAELTKTKDVESAPQGKNDATLNGHSQFNERTVTTGGEDAADESTFPITSNKTTQQQEVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPJ5</accession>
    <name>A0A1B7YPJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mold-specific protein MS95</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162477.1">
        <property type="nucleotide sequence ID" value="XM_018297661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPJ5"/>
    <dbReference type="GeneID" id="28861768"/>
    <dbReference type="KEGG" id="chig:CH63R_02686"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02686"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="34907" checksum="E98D617EC7599F9C" modified="2016-11-02" version="1">MSYGGNDDSNYGSSRRDNEDSYGTSGTTGYSSSATRRNDDDNDNSFGSSTTRRDNEDSYGSSTTRRDNDTFDSYGSSGLGRSGNDSTYSSSRGDNDNTYGSSTTRRDNDASDSYGSTRRDNDTSDSYGSSTTRRNNDNDNDDSYGSSRKTGSSAFDSTSSNLAGADSLSYNASENKGRTYDNDESSYGTTTTGSRRDNDTSDSYGSSTRRDNDTSDSYGSSTRRDNDTSDSYDSSTRRDNDTSDSYGSSTRRDNDTSDSYGSSTTRRNNDNDDSYGNSGDRKGDSTVGKILEKAGDLLNSDKLGSKGQAKREKAGFGNDDNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ86</accession>
    <name>A0A1B7YQ86_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_02784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162575.1">
        <property type="nucleotide sequence ID" value="XM_018297759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ86"/>
    <dbReference type="GeneID" id="28861866"/>
    <dbReference type="KEGG" id="chig:CH63R_02784"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02784"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000119">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="294"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="442"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="53744" checksum="663A1CBC946F3348" modified="2016-11-02" version="1">MWQSFVCAMTAAVVLQAFDPFRTGQLVMYQVKFSTSWHGFELIPFVLLGILGGIYGGLFIKANMAVARWKKNTSWLPGPITQVAAIALLTALINYPNHYMKFQTSELVSNLFVECSKYVDDQIGLCKTGAASTPTIVLLIFGAILGFFLATVTFGLQLPAGIILPSMAIGALTGRAVGIIMEIWVTNHPAFFPFASCEPDVPCVTPGTYAIIGAAATLAGVTRMTVSIVVIMFELTGALTYVLPIMIAVMISKWVGDAFSRKGIYEAWIHFNEYPFLDNSEEVVIPDIPASQIMTRIEDLVVITATGHTIGSLKNILDTHPYRGFPVISDPREALLLGYISRAELTYNLQMCSQPPRSLPPETEAFFSHQPLADPRTTLDLRPWMDQTPITMTSRSTLHLTVSYFQKLGLRYVLFSHRGALQGLLTKKDVWYVLNGAEETRRTSGLPRDMGVETGLTREDGAGEQRGLLRDDGQEDGISPADERETML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRM9</accession>
    <name>A0A1B7YRM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH63R_03338</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163129.1">
        <property type="nucleotide sequence ID" value="XM_018298313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28862420"/>
    <dbReference type="KEGG" id="chig:CH63R_03338"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03338"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="59"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="217"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="694"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1521"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="1863"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR14612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2281" mass="254463" checksum="1D91F441DA79C9E3" modified="2016-11-02" version="1">MTEITAANGTGRTVPQVNGNASYAEKHQIADHFIGGNKLSNAPASKVKDFVAQQDGHTVITNVLIANNGIAAVKEIRSVRKWAYETFGDEKAIQFTVMATPEDLAANADYIRMADHYVEVPGGTNNHNYANVELIVDIAERMNVHAVWAGWGHASENPKLPESLAASPKKIVFIGPPGSAMRSLGDKISSTIVAQHAEVPCIPWSGTGVNAVEIDSNGIVTVADDTYIKGCVTSWQEGLEKAKAIGFPVMIKASEGGGGKGIRKALSEEGFEQLYKAAAGEIPGSPIFIMKLAGNARHLEVQLLADQYGNNISLFGRDCSVQRRHQKIIEEAPVTIAKDITFKAMEDAAVRLGRLVGYVSAGTVEYLYSHADDKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPLHRIRDIRLLYGVDPRTSTEIDFEFKQEGSEKTQRRPRPKGHTTACRITSEDPGEGFKPSNGVMHDLNFRSSSNVWGYFSVSTASSIHSFSDSQFGHIFAYGENRAASRKHMVVALKELSIRGDFRTTVEYLIKLLETEAFEDNTITTGWLDELITKKLTAERPDPMLAVVCGAVTKAHLASEACMTEYRTSLEKGQVPSKDILKTVFAIDFIYEGFRYKFTATRASTDSYHLFINGSKCSVGVRVLSDGGLLILLDGRSHSVYWKEEVGATRLSVDGKTCLLEQENDPTQLRTPSPGKLVKYLVENGEHVKAGQPFAEVEVMKMYMPLIAAEDGFVQLIKQPGATLEAGDILGILALDDPSRVKQAQPFVGQLPVYGEPVAVGTKPAQRFDLLHNTLKNILLGYDNSVIMAATLKQLVEVLRNPELPYSQWNAQFAALHSRMPQKLDSQFSQIVDRAKTRHADFPAKPLHKAFHRFLEENVAAGDADMLKTTLAPLTDVLNAYSEGQKAHELNIVKELLASYIEIERLFTGYGTQEDSVILKLRDQNKDDIRKVVQTVLSHSRVGAKSSLILAILEEYRPNKPNVGNVAKYLRPALQELTELQSSRTTSKVSLKAREIMIQCSLPSLEERTAQMEHILRSSVVESRYGEASWDHREPSLEVIKEVVDSKYTVFDVLTLFFAHEDPYVSVAALEVYVRRAYRAYILKQIEYHSDESDTPLFVTWDFALRKIGQSEYGLPLQSAAPSSPATPSASGGSFDFKRIHSISDMSYLNHKWDSEPNRKGVIVPVKYLDDAEDLLGKALETLALSDKARKRSTPGLIPDLSGKRKPTTAKVDSDELSAVINVAVRDAESKSDQEILSRIVPIVEQFKEDLLNRNVRRITFICGRNDGAYPGYYTFRGPEYVEDDSIRHSEPALAFQLELGRLAKFHIKPVFTENKNIHVYEGIGKAVDGDKRYFTRAVIRPGRLRDEIPTAEYLISEADRVINDIFDALEIIGNNNSDLNQVFINFTPVFQLHPQEVESSLQGFLDRFGARAWRLRVAQVEIRIICTDPQTGVPYPLRVIITNTSGYVVDVDIYAERKSEKGEWVFNSIGGTKEKGPMHLLPVSTPYPTKNPLQPKRYKAHLMGTQYVYDFPELFRQAIQNSWTQSVKKHGAVGGQQPKSGECVTYTELVLDDKDTLQEVNREPGTNTCGMVGWIFHAKTPEYPKGRKFIVVANDITYMIGSFGPKEDNYFYKCTELARKLGIPRIYLSANSGARLGVANELMPHFKVAWNDASKQDNGFKYLYLDDEAQKRFSKDVITEVISEDGEKRHKIVTIIGAEDGLGVECLRGSGLIAGATSKAYNDIFTITLVTCRSVGIGAYLVRLGQRAVQIEGQPIILTGAPALNNVLGREIYTSNLQLGGTQIMYRNGVSHMTGTDDFDGVSKIVEWMSFIPEKRGSPIPVSPSTDVWDRDVVYTPPQKQPYDVRWMIGGRPTEEGDFEPGLFDKDSFVETLGGWARTVVVGRARLGGIPMGVIAVETRSVENITPADPANPDSIEQVTNEAGGVWYPNSAFKTAQAINDFNNGEQLPLMILANWRGFSGGQRDMYNEVLKYGSYIVDALVKFEQPIFVYIPPFGELRGGSWVVVDPTINPEAMEMYADVDARGGVLEPEGIIGIKYRKDKQLETMARLDPVYASLKKQMATDLPKEQADELKKKMTIREKQLLPVYSQIAIQFADLHDRSGRMKAKGVIRDQLEWVNSRRFFYWRLRRRLNEEYLLRRMSSTVLTSTSGSDIKAPEARKRNLQFLESWSGVVNFNTADREVSEWYEANRKSITDRIESVKADNLATELSSVLRTNKNAAMRGVRDVIRTMPPEERDQILKYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT11</accession>
    <name>A0A1B7YT11_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163609.1">
        <property type="nucleotide sequence ID" value="XM_018295247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT11"/>
    <dbReference type="GeneID" id="28859354"/>
    <dbReference type="KEGG" id="chig:CH63R_00272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00272"/>
    <dbReference type="OrthoDB" id="4526039at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601906" evidence="2">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="324" mass="35098" checksum="8E92C30112C37F54" modified="2016-11-02" version="1">MLVFRRLIPYALMVSLGAQAEAGEDSPPGLPPLPDRTNRTSNNVRDAVVHANATGSWPFRGIDITKPMDHPPDDEVGEGNGWSINIAVATNTTSNTGSSSQPRGNPQYIYINAPEDAFENPDSASTSPEDWTTCAVVWLGNRWSVEEIEQLHQDPDGACNEVISEECISGLRQKLLDTGCWLWGGELPEGCPGAVSDVMVMTNTLEFSAEKHSYEVSASPGPHSNLTEVGLRAAYDEALTKVFPMMLLYQYDDGEVKSDYTVFRCILASNVTEGSREPESFGEIRSGLFGIGESSARRNPSSASWLITGLAVCLAVSFFAQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTG7</accession>
    <name>A0A1B7YTG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163848.1">
        <property type="nucleotide sequence ID" value="XM_018295486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTG7"/>
    <dbReference type="GeneID" id="28859593"/>
    <dbReference type="KEGG" id="chig:CH63R_00511"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00511"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1077" mass="118307" checksum="52DDEE17A632A94B" modified="2016-11-02" version="1">MSSYRVPESQRKTREHRPHDDRDDWEDEDVVTPIMDDDQVLIMDKTAAPSPLKLNKPASTRLSQPRYSVQKLKRLKSRQRQKAQNAKAGIKVVTDMTTLQQQQTAQQNRNPDLQQPKFVDAAALRALEGSPNSASVGNWNWLKKKTDHVGKSPQSASRSPLEQDLSPNDRPIVIGIALPPDMADREISPQTAVLKTPHDLPPGYANKHSVTSKPDTVTPLTPSQQRSVWSPDTPDTTSPFQSPHRSSSIYSQATGLGVRVARDAPPVPSVPSTYKQPERVVSVVLKDNEEEDNDGGSPCTLFEEDGAAASNCRRSTKTKEVAKSPDSAATQTRGWWDHITTPFLERKSPVVQNNSESQPVKAAEHGDYGSEKDTNMPAYKPRDSGPGIIKPSQIQPTTIQRPGLPASPKPSARNFQTPIVKIPTPRRTPSPLMDRRDPSPTASSRSATPRLQVQSEKVSLAEPSPAISEQPPPYSPPQQQKAVRYRAVFPTGHPLQALYPPSPGPISPAINGTMSSQGGIKMTDIPLTPSTGGNGFAPSTQVRLPERLAGTFIPGEHFLEASGNGHRVERERRRHEREEMTARKIGGFWRGRWCIPASGCYGRSGREGRKRRRVCLGVCGVGLALSILTIVLCITLIPRNNNSAQVDSIFVNLTDFPPMPTGVLSVVGPDNTAAVTGCSSPSTVWSCALPKEEHNSVAPYRANQPTFIMHIQWDNDTRNLWHVPNGELPRPGSSSQKRGSSFGGIISRARSYIRRQGSAFSPSPTPPAFEELYFLGNTTDGIESAEKAGEPTPFYLSVLKSGNESVGSSALDRRQNLEEPSGDISISLPPPDLEGDGTGAPAQLFPHVSQQPVRLYDRGLPTEHYGFYNYFKRTIYLKSVTTPNGTEDESNVPLDTNGGSRRSEAKFLVTWSQTRFLVQIWTRSTNSTQLLASNDGERPGTMPYPVTVKMDTHGGRSGEKFVWHWSVNDRQGIDTANPKLLPNDIGFGGAMVNPRKDRDASFGGFDGGTDDLAFTLQQDCDNNKITKQDTEGKRKLDWETDWETKGRIFQDKTGRKLPKIATPLWLNSAPVGLSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUF2</accession>
    <name>A0A1B7YUF2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GRASP55/65 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_00847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164184.1">
        <property type="nucleotide sequence ID" value="XM_018295822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUF2"/>
    <dbReference type="GeneID" id="28859929"/>
    <dbReference type="KEGG" id="chig:CH63R_00847"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00847"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="370" mass="39023" checksum="51D187DD0D3ADE37" modified="2016-11-02" version="1">MFNALNRFMSRLDGQQPTHQNNNQGSFGFQVLRNTNLELNIEPWFDFIIGINGRPIDNPDPRLFAQEVRNCAGGTLSLGLWSAKGQRTRELHAQVPHDTASLGLSLQWTPLAVAANIWHVLDVAANSPADAAGLLPYGDYILGSPEGALHGEGGLSELVEDHIGRPLRLYVYNNEYDVTREVTIQPTREWGGEGALGCVLGYGALHRLPAPLNEPVHAPGEMMFDGEKDPAAALYGASAVGAGGLGGDTQQQDLFVPAAAAGIGAGALPSGGDFLVPAQMVDASGAPPPPPPAGTATTRKKKERHHGGNNFMDDYFKEEEKKSREADNAPSGRGTPVAPPPKTGGPPPPPRAGSAGPPKEEQQAAAPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUJ6</accession>
    <name>A0A1B7YUJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-containing superfamily Amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164210.1">
        <property type="nucleotide sequence ID" value="XM_018295848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUJ6"/>
    <dbReference type="GeneID" id="28859955"/>
    <dbReference type="KEGG" id="chig:CH63R_00873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00873"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601950" evidence="1">
        <location>
            <begin position="25"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="50653" checksum="BB6B7E3E35AC8BC4" modified="2016-11-02" version="1">MKLSNLALPAMALTLARTAAGAAATPCSESDIDVDVAIIGGGSAGIHAAIHLRDAGATVAVVEKKSQIGGHAETYTNPRTGVPGNVGVSLFENTDVVSGYFARLNVSAARVNPLNGGGASPSYDFSSGVRIPVPNASEAAARQEALQTAVRSYKTNVLAKYLWIDQSFHVPDPVPEELTVPFAELAQRYGFSALLTVIAQFNWFTGDISTIPALYGIKGLGPGLLNSIFGEFIVSASGDTRALYDAAAAELGDSVLLNADVVEVRRDVPVDEDDATGVTVLIQQPEQPLKLIRARKLLFAIPPTLDNVGAYDLTAEESGLFSKFSALGYWAAVANIPGLDTSLTNVGARTPFNQPVIPGPNGIDGYGSPEDFVVMVGFRDTAYSDADGQAVVRGNLATLGAVGAVPADAAERATFPFSSDHGPYNLRVSAEEIRAGFYRRFLALEGARNTYWAGAALTGHNSALVWNFNLGTVLPGLKKDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUV7</accession>
    <name>A0A1B7YUV7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Involucrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <sequence length="7954" mass="855816" checksum="DF3FA08A5805945F" modified="2016-11-02" version="1">[encoded data, 7954 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVP7</accession>
    <name>A0A1B7YVP7_COLHI</name>
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        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">CH63R_01212</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
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            </authorList>
            <dbReference type="PubMed" id="28851275"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="2">Secondary metabolite biosynthesis.</text>
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        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="565" mass="62628" checksum="8EFAEED16C0C400D" modified="2016-11-02" version="1">MPNTALNMDGVLSVFVRSLTVAVLVAAVGSVLYFVKLLRKHRGKMAELRRQGLPVVPHSFLFGNLLEAKKAFDSLPAGVHANYVLSKLGEPFKDGGAFYVDTWPMADPMLMVMDPDMAHQTVYHPVAGSAKPPMLTGWFHPITGGPSQFDTNGRPWKHLHGLFSPSFSAQNITAAVPIIVGNVATFTDRLRAKAADGAMFRLEPLMLDLITDMIGEALFNMRLETQKRRHPLAEAMKGQLRLKFTAHKPENLVARVDPVLLFRTWNGGRVLDNHIKRQVRARFRTLLQNRAHNRDKAESFQSVLDCALENWLALPQNAGRAELDADYLAVVTRNMRMFFFAGYDSTASAVVYCLHNIASRPAVLARVRAEHDDVLGADLASTPARIAENPALLNALPYTNACIKESLRLFPPAGAIRQGCADLVLRDAAGNAYPTDGIAVNMLHWVIHRNPKYWARPDEFLPERWLVTDPAHELYPPKGGWRVFEYGPRLCVGQQLVMTETRAVLACVVREFDIRDCYAELDGDKKIDLSGLGGQRVFMVESGAAHPTDGYPCRVSLSGYRGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVZ3</accession>
    <name>A0A1B7YVZ3_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
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    </protein>
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    </gene>
    <organism evidence="2 3">
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        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
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                <person name="Lapalu N."/>
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                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018296371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVZ3"/>
    <dbReference type="GeneID" id="28860478"/>
    <dbReference type="KEGG" id="chig:CH63R_01396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01396"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="539" mass="59556" checksum="02B4C247FE8D5F1B" modified="2016-11-02" version="1">MPEARTRSDTGAQRSPSPAERVPYAGCARSAAARARQLCHLHPNTVFRRVYTSGKEPSSSHTIHHRSYAHQLRAATRTPGLQLTHFHNGNYKTQLVSSLSFCERMAPSDKKLETALLDTVRDVYKTDLDNLTVNFIRKRVESDLELEAGFFSSGKWKDKSKKLVKELATALMEGNADPDPESEEDASAKPKKTGKRQSADTSPPAKRRKRASAQKEEDLEDSGIESDKPEPKSKPKPKPKKAAPRKKKQDTPVIDSDSEPSPVKSNPSKARNGRASKIEDSGSDDLSSPPDSDEDALESQKAETEDEKPKAPLEKEVTASVDTKEDKPTGKNPQVTTERKDEVKPAMDDTSSELSDVIDEPPKPKRKKKEAGAGSKAPKPKKASAAPENPDDAEVKKLQSQLVKCGIRKIWGFELKQYGDDTKAKIRHLRELLKDIGMDGRFSEAKAKEIKERRELEADLEAVQEMNANWGAGGRSSRSKARGQPALKKATEDDVSVPENDKQNDDDDDEEQEAHIPSRARGKARADLAFLGDDDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW00</accession>
    <name>A0A1B7YW00_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_01304</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164641.1">
        <property type="nucleotide sequence ID" value="XM_018296279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW00"/>
    <dbReference type="GeneID" id="28860386"/>
    <dbReference type="KEGG" id="chig:CH63R_01304"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01304"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF11">
        <property type="entry name" value="EXOPOLYGALACTURONASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601948" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="430" mass="46249" checksum="EAEBFC8656FF2429" modified="2016-11-02" version="1">MLYRHLLPLALCLAGSASAACGQRCVIASSGNSTSDAAAIADAFVKCASDAEIVFSEGVEYKAFEPVVATKLSNVVITVAGNLSLPQDIPAMQKLVELKGGSLTWFQIGGTNVKWIGSAEPDAGWIKSYGQAWWDLNKPGEAGTPNRPHLMQFSVTNGVMRNMKSLKPIGWNFSIKGKNITIANTVIDARSESSSFPFNTDGFDVGATDVTITNSNIFNGDDAIAINDGAKNVLFRDATIGFETHGMSVGSLGSKPASPADVQNIRFEDVTVRGGLYAARFKSWIGGQGLAKNITWSNIRVDNVTFPIFVTQTYYNQASVSGERPNNSSVMMEDFTWEHFSGNINTYNPGDGSCTTNPCWYNAGLGNLTHSEAIIIECNTEKSCKNFRTKDIKVEPQSKTVPKVICMNAMPDLNPKLGFECANGTFVPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWX4</accession>
    <name>A0A1B7YWX4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164971.1">
        <property type="nucleotide sequence ID" value="XM_018296609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWX4"/>
    <dbReference type="GeneID" id="28860716"/>
    <dbReference type="KEGG" id="chig:CH63R_01634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01634"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008602002" evidence="5">
        <location>
            <begin position="25"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="338"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR16454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="536" mass="59189" checksum="018A944A88E3422D" modified="2016-11-02" version="1">MRSLRLVPLLASLLALVTTITAAASSVKKCRDETFQNPVLYEDYPDNDVSVGPDGAFYFSASNFHYSPGAPILRSLDLVNWEPVGHSIPRMNFGDGYDLPPGGPRAYRGGTWASTLRYRESDGLWYWIGCTNFWITWVFTASSVEGPWYNRANFGGGTCMYDNGLLIDDDDTMYVVYGNGQVKVAQLAADGLSVVRTEQVLQASDVNTETVEGNRMYKINGTYYILNDQPGSTTYVWKSSSPWGPYEAKILGQNVAPPLAGGNSPHQGSLVQTAKGDWYFVSFTWAYPAGRMPVLAPVVWGADGFPELVRGSNGGWGSSYPLPLPSRPLYNWTRTYRFEEDGVLPPTWEWNHNPDVASYRVGNGVTLRAASVTEDLYSARNTLTHRIHGEFPKGTVEIDFANLADGDRFGLAAFRDQSAYIGIHREGGQYTLKAVHGITIDEWSGAPVSPGREVASAPVPAGARKVWFRAELDARPTGTREAVFLYSFDGVRFTKLGESYELYSGWAFFIAYRYGIFNFATKQLGGSIRVESFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UUV6</accession>
    <name>H1UUV6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04327</name>
        <name evidence="6" type="ORF">CH63R_01302</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000066">
        <property type="protein sequence ID" value="CCF31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164639.1">
        <property type="nucleotide sequence ID" value="XM_018296277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UUV6"/>
    <dbReference type="STRING" id="759273.H1UUV6"/>
    <dbReference type="GeneID" id="28860384"/>
    <dbReference type="KEGG" id="chig:CH63R_01302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01302"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045863_0_0_1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="215"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR16122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="422" mass="46611" checksum="7A315C61A3469C11" modified="2012-03-21" version="1">MSAITKSLNALARHGARKPALNQARPLATVTDYNVAKMAATMPPGHKAKVAQLETFTLPERVTGSKGDRAMGKALVDAWRRDGILQVSMNDKQQAIFDEATAASKAFFAKPHEEKAACVDSQSYSGYIASGEEITDGIADYSEIFTVTKDLDMSEPRVRAKWPCHGPAPWPDYDMKQPMTTYMDYLGESGEKLLQLAELGLNVPAGSLTNLTDDGWHHMRILRFPPTHNTNGKGKAGRGIGSHTDYGLLVIAAQDDVGGLFIRPPYDGEHYANWEKSSAGLKEDDEGWHYVPPVPNVFTVFPGDIMQYITNSYLPSTPHKVGLNTRDRFAFAYFHEPSFQAVAKPLPGYDVGQSPQEGIHYGTHFTNMFLRNYPERITTKRMHAENRLALLQKEELRTLGSKPPGVDRVLPSAGQQTPHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVS2</accession>
    <name>H1UVS2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00749</name>
        <name evidence="8" type="ORF">CH63R_04356</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000313">
        <property type="protein sequence ID" value="CCF32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160577.1">
        <property type="nucleotide sequence ID" value="XM_018299331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVS2"/>
    <dbReference type="STRING" id="759273.H1UVS2"/>
    <dbReference type="GeneID" id="28863438"/>
    <dbReference type="KEGG" id="chig:CH63R_04356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04356"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_1_1_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="600" mass="67514" checksum="B8D6D71ED6A9313B" modified="2012-03-21" version="1">MGVGTAIDDKEKCVGLEKDEDAHSSDSDDDYQKAVEVTFEPGNPYRRKSSLVTSDTSRPLPRHPSRRTECIVHQFLESQRKARDAVASASNHGSRSNSTSSASKANDHLHHGHPTYESPNRQAGAKDVCRETGMSKTVEPKGRVAKQRASILAADSPEDSDIGQADEKSWRSEIIKSASQVDLAQSDDEDELHSRLLTKKQLSEMAWGVRELSRRLSSMRIRFRVKTIFLLTKIHDADLISRTRELTKWLLSHERDVDYTVYVEEKFKDNKKFNALGMVEELSKEALDAGQPQTKASDDVISKRLRYWDEDMCRNRPHMFDFAITLGGDGTVLYASWLFQRIVPPVLSFSLGSLGFLTKFDFEEHRTILESAFNKGVTVSLRLRFEGTIMRSQQRKRLADAEESSSSQDDDGHKPDLVEELVGEEREDEHTHKPDGTFEILNEIVVDRGPNPTMSYTEIFGDDEHFTSVLADGICVSTPTGSTAYNLAAGGSLCHPENPVMLVTAICAHTLSFRPIILPDTIVLRIGVPYDARTNSWASFDGRERMELFPGDYVTISASRYPFASVQAQGRRSEDWVNSISGKLGWNTRQKQKGYKEWDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW73</accession>
    <name>H1UW73_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septum formation initiator domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00773</name>
        <name evidence="4" type="ORF">CH63R_00691</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000358">
        <property type="protein sequence ID" value="CCF32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164028.1">
        <property type="nucleotide sequence ID" value="XM_018295666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW73"/>
    <dbReference type="STRING" id="759273.H1UW73"/>
    <dbReference type="GeneID" id="28859773"/>
    <dbReference type="KEGG" id="chig:CH63R_00691"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00691"/>
    <dbReference type="eggNOG" id="ENOG502S40Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052208_0_0_1"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46935" checksum="4219AD8996246231" modified="2012-03-21" version="1">MSANAHGFELPSTSASTLATTAAAIGNLPNNHSNGVNSRSSSHIRSKSRHDKRASAPAPTPPVTAATASTATAAAAALLPARRPRHQITRSITEFSPPLRMHRHRHSHHHHPMQHALHINAQSRRDRDRLLLLDERTSAPGADGRSSLDMTRSEHVTPNRSPDSSRRTSALVGPAIGGGENPFLVTPPGRTRKVDKAAVLSEEKNRTASRVMGLKNSLVELSGFSTATTRHLDETYYSVLEKKSMLQSTVTAMRELTVASRQLTGEFEGQAEEMSREVAAQLDQFGLFGEQESRIEALQSRVEAGRTRIQGLSERVDLVRRRIEGWESADREWQEKTRKRLRTVWIVMSVVFAVLILLFVGAQYLGGPEVEDRKGLEGAEREFNRSMGVLGKKGPREKLLPPLWEGRNGREEEEDRLRVFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWJ0</accession>
    <name>H1UWJ0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04745</name>
        <name evidence="9" type="ORF">CH63R_03075</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018298050.1"/>
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    <dbReference type="STRING" id="759273.H1UWJ0"/>
    <dbReference type="GeneID" id="28862157"/>
    <dbReference type="KEGG" id="chig:CH63R_03075"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03075"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
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    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
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    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
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    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
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    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
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        <location>
            <begin position="278"/>
            <end position="397"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="332"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32341.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR14349.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <sequence length="404" mass="44597" checksum="5576608FF0ED3A0A" modified="2012-03-21" version="1">MNGITRNATLAARKQLSAASFVCRTCRQHRQRRPYSSNVVPPPPAPPTAGYAALPSRRLISVAGPDAAKFLQGVITRNIASKEARERQTGFYAAFLNATGRVLHDVFIYPDIAGLGGAAAAESEQAGTRFLIEVDANEAERLAKHIKRYKLRAKLNVRLLAADEATVWHAWDDGGKPITTDAALLSTVTKDPRTPGLGYRLLQGRDTPPPLDLDATTEDSYTIRRYMQGVAEGQDEIIREHALPQETNMDYMDGIDYHKGCYVGQELTIRTKHRGVVRKRILPCMVYEMDRAVPQTLQYRPEHDADHGPEGLPAETIPRETSIGRSGKRGRSAGKWLKGVGNVGLGLCRLEIMTDIVLPGETAASTFDPADEFMLQWGEEDKNNTVKIKAFVPEWLRNGLASAR</sequence>
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        <name evidence="11" type="ORF">CH63R_00618</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CACQ02000396">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018163955.1">
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    <dbReference type="AlphaFoldDB" id="H1UWJ4"/>
    <dbReference type="STRING" id="759273.H1UWJ4"/>
    <dbReference type="GeneID" id="28859700"/>
    <dbReference type="KEGG" id="chig:CH63R_00618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00618"/>
    <dbReference type="eggNOG" id="KOG0922">
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    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="348"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="788" mass="86987" checksum="CDBC97D73B43A89A" modified="2012-03-21" version="1">MSPIPGGERASKKRKLNDKNVIKVGNKVISLEGYLNPPAKKEKVVQQESAREQALEKTENEASKATTEDSEKPGHTAPSFIKHQSKRPHDKGRPRSDRGPRWREDPALLKIRQKLPIWAHREDIRTRMAEKDVLLLVGETGSGKSTQVPQFLVREPWCRRQVVNIDGREASVGGMIAVTQPRRVAATTLAHRVSREAGTPLGESREGMVGYSVRFDHQVPKGTKIKFLTEGMLLQELLRDPSLRQYSAVVVDEIHERSVDVDLVSGFLKQILLSDRKGRGGIPLKVVVMSATADVERIQGFFNITDGSQTEEVEGDKPSSVEVLKIQGRQFPVKTIHTPKPVPDIQESFLQTIFKIHTEEPLPGDILAFLTGQEEIESAQSLIEEYAATLASNVPKIKVLPLFGQLSMEGQHAAFQPVKGGFTRKIVLATNIAETSVTVPGVRYVVDGGKAKVKQFRARLGMESLLAKPISKSSAIQRTGRAGREGPGKCFRLYTEGTFGSLEETDLPEILRIDVLGAVLTMKARGIDDILGFPLMDTPDVEAIERALVSLHGLGALADDGTITEAGRKMAGFPIAAPLGAVLLAAARPEFDCVLEAIDIISCITSGDDIFHQLQSEEQREEIEELRKELYRREGDIITYLTTMQQYAAENTDRIQWCKKRKVNMRNMKTALNIRKQLRSLCLKEGLLAEAPPPDPQPFAPLAPEQAEALLKCFLRGFVSKTAVLAPDASYVTSQGKHVVAIHPSSVLHGQKKEAIMFLEHVFTQKNYAKKVSVIQANWIVEALEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXD2</accession>
    <name>H1UXD2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_04979</name>
        <name evidence="10" type="ORF">CH63R_01676</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000486">
        <property type="protein sequence ID" value="CCF32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165013.1">
        <property type="nucleotide sequence ID" value="XM_018296651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXD2"/>
    <dbReference type="STRING" id="759273.H1UXD2"/>
    <dbReference type="GeneID" id="28860758"/>
    <dbReference type="KEGG" id="chig:CH63R_01676"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01676"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_27_3_1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="707" mass="78071" checksum="C2C20D5F3A5D6CCC" modified="2012-03-21" version="1">MSVRVVARIRPLLEKELDKDTIVRADSTDEGKPATLVKIPNPKNEGEEFSFAFNSVYDQATTQDELFTSEVAPHIKALFQGLDVTIFAYGVTGTGKTHTMRGGLKLADRGVIPRLLSGVYRRGKKITKDTNGETTVDVALSYYEIYNDKVFDLFEPPEKRQPAGLPLREKDGKTMVVGLSERACEDLHDFSRLYIEANNNRVTAATKLNAHSSRSHAIMRVKVTQTTGDQVLESTASAIDLAGSEDNRRTDNGKERLVESAAINKSLFVLSQCIDAISRGDKRIPYRESKMTRILSLGQNNGITIMILNLAPIRSYHLDTLSSLNVSSRAKRIEVREIENEVVFKQVPRTNSAGSAMAQRQPLRPLPNAHNIHSGTIASKANEKADVTRPVKLFNVYTDRSKTVAPARPTANTTQLRKPLVAPKVTKIAQPPQAPQPAQQKLSISAEQLEAIVEKKVSEILASRESKTAEPAPTPAHPDINDAVRRRLEALERRIESEERERDDTRSEGLRCLLAARQAKEAGNDVVALQMYEQALPFFPGQAKLLGKIEKLRSKLGNKLPTESAWAPAVSRDKHEKKRRRISDESDDEFHQEASANEDMSFVDVSAKTKSRKAKPTKNHTTVFPEVTGPASPQTQNLLNIVNSRDIAQIKGLHGFGSKKAQDLVDYLDTRSEEGGAQIESLAQLKTVPGMGGRTVERAYDGLVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0D6</accession>
    <name>H1V0D6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_05833</name>
        <name evidence="8" type="ORF">CH63R_01513</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CACQ02000856">
        <property type="protein sequence ID" value="CCF33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164850.1">
        <property type="nucleotide sequence ID" value="XM_018296488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0D6"/>
    <dbReference type="STRING" id="759273.H1V0D6"/>
    <dbReference type="GeneID" id="28860595"/>
    <dbReference type="KEGG" id="chig:CH63R_01513"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01513"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018202_0_1_1"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF34">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="132"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="52123" checksum="A1FDF96920CBBF00" modified="2012-03-21" version="1">MPARLVVCNQAPVPLFGVLRRQGAARYNSTAAAAATTTTVTPVGKTTQTAASSTQGKSPLSRLPTLALVRSLVLTQFMSSPLLMKPALPLLHFIAKSKMALFNPDRNPVLNRLLRWTIYDHFCAGENLQQVTKTVNSVKRMGYQGVILNYAKEIVLDTKEAGADAPAGDYAAPFYEMVDLWKKGNIETLRMLAPGDFLAVKITGAGPIAVDAMRAHAPIPDVIRDALDEMCDEARKQGSRLWIDAEQQALQPQLDEWTIDLMRRHNRESKPLVYNTIQSYLKASKAKAERHMALAAREGWSLGVKLVRGAYIENETRSLIHDTKEDTDRNFDDITDMFISQRLPPSADASLSFPSSALFLATHNAASSSTAIANHRRRLLDGLPTTELECGQLLGMADELSCELLDNYDACLADSGLRREAIPKPFKYLPWGSVSECMGYLHRRAVENKGAIEQSAHMLGSLKSELRRRVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H1V243</accession>
    <name>H1V243_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_06323</name>
        <name evidence="12" type="ORF">CH63R_10757</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
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        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
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    <dbReference type="OrthoDB" id="5152799at2759"/>
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    </dbReference>
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    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1"/>
            <end position="20"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V314</accession>
    <name>H1V314_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_01172</name>
        <name evidence="9" type="ORF">CH63R_00010</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="3">Homodimer.</text>
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        <text evidence="2">Belongs to the PhyH family.</text>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
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        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF34616.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR14830.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="310" mass="35237" checksum="3C598FFD4D24B9C4" modified="2012-03-21" version="1">MPNVSANYGPEVQKVPADTPIEDIIYLLKRDGGVFLKQLIPVVDVDQAWEECRERLENDVEWNGSFFPKQTQRATALLALSPTYAKTQVMNSVYQQVCDHFLTTRSCFWWGSERKESVSKPYVHSCTAMRIGPGGKAQPLHRDDYISHNHHPEVGSWDDERDKNRESAVGLFVAGSKVTKENGGTQFIPRSHLWGTDRDVPPRVEDCIYAEMEKGDAFIMLASAYHAGGHNTTKDEKRLVFATFVTRGYLRQEENQFLSVPQEIAKQYDRPIQEFMGYAISEPACGYVDQLDPIFILRPELKGDGRPTDF</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3U1</accession>
    <name>H1V3U1_COLHI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_06799</name>
        <name evidence="7" type="ORF">CH63R_04882</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001315">
        <property type="protein sequence ID" value="CCF34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161103.1">
        <property type="nucleotide sequence ID" value="XM_018299857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3U1"/>
    <dbReference type="GeneID" id="28863964"/>
    <dbReference type="KEGG" id="chig:CH63R_04882"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04882"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2372675_0_0_1"/>
    <dbReference type="OrthoDB" id="4834148at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="95" mass="11085" checksum="E68032F205AF4752" modified="2012-03-21" version="1">MASALKESVPRDKWWEWRWFSPDDTKEERRLITKIDLLLVPYSVLGYWVKYVDQSNLNNAYVAGLKEDLGFYGNELVQLQTLFTLGSVLGQIPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V421</accession>
    <name>H1V421_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00009</name>
        <name evidence="4" type="ORF">CH63R_11084</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
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                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
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                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
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                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
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                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Will I."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="Zampounis A."/>
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                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
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                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
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            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
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                <person name="Will I."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
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                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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    <sequence length="938" mass="105395" checksum="033456D14FE62911" modified="2012-03-21" version="1">MSRNQSPVQEVHDDPDGYEFQIALDQLSAGSTEALRLYLARKNGQDPATVSLRTTPWKPSTSEGTKLYFAGKLDDTRAPVDKDGAVVDEAREMPRVIFEDTEKPFDYKALDAESRQFRLLRLAPPDEHGVTRQFQLETFSLNDAPPYFCLSYVWGDPERFLGVNCNGEMISVTQNLYHALRTCFNRHPDSWLWADGICVNQEDVVERSQQVLLMGDIYRNASMVLAHPGHFSYVRKQPEEEDVKRTVLADRLGSLGMQDMLSFGAETPAEEKTRVGEEKPYGIAEFALEPLDDAYDPGNIQGAISIMTYMTRVWSDTRRDKILSDLQWNEMNLPDPGTESGREIWDNLVRFWTTDWYFRTWVLQEVILGAKVVVLYGTTAISLEAITEFWDLARRRGLPRPLRIGAYADIFNMVLHLSPVASFKILRDRREGLDNSPENVEDDVQPLGGRQNQNDVGILTPINGNKNSKASENAAVHSSSLLELLCLTRNNLATDPRDKIYGLLGLTDDMVARSTVPDYSHDNTPAKVFIEVATHMVELGHAADLLHHAGIDQAVRGLPSWAPDWTMQSRSTLPVHLYNCLPDTSPTVSILSSDEKPNLRVRGAVLARINTPGPAWRYYSHDPSSPPFSSFKNARETEIPPFNDEDARNFILAFLSYAAEGSLEERHRPEALNDALVRTLAVDCSWQNERIGIRRPPQDVEKTQAIETAAGVSEAPTTSASASASASASDAFFAGVDAFRRFYARGPDSEEDLKEPGIRLHQTHIFQWLLDFDQKVEADLQQRMVPFTVPFQEAQRGRRWAAIGTRGPKTTEDLTQDAAKKAEDPSKHSYDTKALTDCFMGTVPWDAETEDYVVLLEGFRTPFVLRKSPEETTSDGKSVFNLIGDCYVHDAMDGQLMAWADEMEEELQRCQVGKDARGRAYVIRTPGGFASFEDFIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4R6</accession>
    <name>H1V4R6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 4A10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07049</name>
        <name evidence="8" type="ORF">CH63R_00143</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001448">
        <property type="protein sequence ID" value="CCF35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163480.1">
        <property type="nucleotide sequence ID" value="XM_018295118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4R6"/>
    <dbReference type="STRING" id="759273.H1V4R6"/>
    <dbReference type="GeneID" id="28859225"/>
    <dbReference type="KEGG" id="chig:CH63R_00143"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00143"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_4_1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF234">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="57440" checksum="685C375912D46840" modified="2012-03-21" version="1">MNAFQNVQVILTKSVAVSLLLLFTYVSLRSVYNVCFHPLRRVPGPFLAKISRLWLFYHDYHGNPHNHIRELHRKLGPLVRISPNEVSVDNVDANNTIYAQNNPWVKPAYHYKAFQSSTAYSIFTELDPQTHAAHSRLLAPAFSQTRVSATDAQRLLWDKCKAMVEGMDDRLGAEKHEDGSSNTITMSLSRCFRSFALDVVTTWTFGHCAESLPTFHSELFEILDVAAESVIYFQHMPFLRALIPYIAPLVPSLVPNKILGQYAKKALESNRAALKGLREIVPCVFSNLVSSQWQEKRGYSPSDGQIISDGIVILAAGADTTAAALSIGIHWLARNPDLWQQLQDELRPVMNSFEKPPRIEALAALPLLNAVLKEGLRVSCPIRGHMPRVVPTEGWNYKGIHFPPGTVVATSAFYGCYNETVFPDPGCYDPMRWLPPKHSSKMEAHLQPFSRGTRQCIGQNLTLAMQRVVIASIVYYFQPVAVDNTTIKTREFVTLLVDSPLEVTLITANRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4X6</accession>
    <name>H1V4X6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase ii complex anp1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_07100</name>
        <name evidence="10" type="ORF">CH63R_08707</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001471">
        <property type="protein sequence ID" value="CCF35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155704.1">
        <property type="nucleotide sequence ID" value="XM_018303681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4X6"/>
    <dbReference type="STRING" id="759273.H1V4X6"/>
    <dbReference type="GeneID" id="28867788"/>
    <dbReference type="KEGG" id="chig:CH63R_08707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08707"/>
    <dbReference type="eggNOG" id="ENOG502QVDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017872_4_2_1"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR07186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="404" mass="46309" checksum="2118AB776A6E9257" modified="2012-03-21" version="1">MLLPKGGINWKSAQSRLPPTRAIWAFLTRTRFLFLIALTGFVLLLWRGIRSSASEMQSFYCWGPAKPPMEMSLNEQASWAGHLQTPVIFNHHEPLEVNHTSIQHVNLNPIKSTRKAVTNEERVLILTPLKDAAPYLSKYFELIAELTYPHHLIDLAFLVGDSKDDTLAILASELDRIQRRPDKIPFNSAMIVEKDFGFGLSQSVEERHSFKAQGPRRMAMGRARNYLLSAAMKPEHSWIYWRDVDIVDSPKKILEDFIAHDTDILVPNIWFHRYRDGRDIEGRFDYNSWVESDKGRRLAASLDKDVVLAEGYKEYDTGRRHMAREGDWRNNKDEELELDGIGGVNILVKGDVHRSGINFPCYAFENQAETEGFAKMAKRAGYRVVGLPNYVVWHIDTEEKPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V518</accession>
    <name>H1V518_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07134</name>
        <name evidence="8" type="ORF">CH63R_13811</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001488">
        <property type="protein sequence ID" value="CCF35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151103.1">
        <property type="nucleotide sequence ID" value="XM_018308785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V518"/>
    <dbReference type="STRING" id="759273.H1V518"/>
    <dbReference type="GeneID" id="28872892"/>
    <dbReference type="KEGG" id="chig:CH63R_13811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13811"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
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            <begin position="1"/>
            <end position="113"/>
        </location>
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            <begin position="213"/>
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        </location>
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        </location>
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            <end position="209"/>
        </location>
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            <begin position="143"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF35320.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR02585.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="406" mass="43353" checksum="8F43DFCDCA1098CB" modified="2012-03-21" version="1">MASNTTYTPNEETEIQQWLTTAARLQQTASADDASPILDTLNSHLSTRTTLLGTKPSKADTALYSAVRPLVAAWSPEQRTGEKGYPHIVRHLDFVQNYPAFSADVKPEDKVPVQLDEVLYVKPPVDAKAEKERLKKEKAAAAAAAGGDKAAAIPDRTKDNKDKSAGEKVKEAVVEAKDKVKAVVAGGDAKPKKEKKEKAPKPQKAAAPAAPLSPALIDLRVGHILKAIKHPEADSLYVSTIAVGDEPNDDTTEYEGQVCRTVCSGLNGLVPLESMQGRKVVVVCNLKPVKMRGIKSCAMVLAASPKLKEGEVDDHKGPVELVTPPADAKAGERVYFEGWEGEPEGVLNPKKKIWETFQPGFTTTDDLAVAFDAGVVEALGKQGVGKLVTKSGGLCTVPSLKDAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5I7</accession>
    <name>H1V5I7_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Pheromone-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07261</name>
        <name evidence="4" type="ORF">CH63R_08213</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001560">
        <property type="protein sequence ID" value="CCF35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157965.1">
        <property type="nucleotide sequence ID" value="XM_018303187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5I7"/>
    <dbReference type="STRING" id="759273.H1V5I7"/>
    <dbReference type="GeneID" id="28867294"/>
    <dbReference type="KEGG" id="chig:CH63R_08213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08213"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007968_1_1_1"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
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            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="453"/>
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    </feature>
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        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
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            <begin position="526"/>
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            <end position="555"/>
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    </feature>
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            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="605" mass="67303" checksum="064E3438F43FA77F" modified="2012-03-21" version="1">MGCLSHRKKVTEQRAEQKWDYINLNDFKSRGCLTPFAYFYLWLMLIISLAVYGVDMFTAVNLLAFDRWSSEIDPAIDFKISKWIFSISIIASFVNIAFEQFRAMRVMKRGNVAECYLDNIAVRLESVRMGKGQGWKRFLVFAELTKSKKGAEYIALFTYFSFQSWIRVLVCSGPRQVVNALTLKSVYDAKLAVHEASVEGSLLGFFDKIKSLATEDYQQALILSGMLFTLVIWVFSALYLIMAVFFYVFFLFHWIPKADGGLSGYCERKVTKALMKIVTAKVNKALARQEESKRKAAKKNGEKLPLERQATLPTLPNVGDPDKLAEMPMFGRSDTFATLPAYESRPGTPGSIELNSMDQKRPLPSRMGTTASTASYSSRAPLVGGAADFGYQRSASPVPSLPPMDLNNYPPARPGTSNSQRSFRPQLSHVQTNSQGSMRGGFSESPAAYSPDVMPPFPPPVRSPTARTMDSYGLQRQNTYQSDRSTPAPRATHDDYSSQSNGRASPAPSAYSTRSGAPLPRGPGPLNNTPYQAYQPFNPTRSATGPVPPRGPPSAPMRNMTAPVPPRPQEDYFTRPGTSQSQRPSPRGQGHGYDDDVESQRDQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6Z8</accession>
    <name>H1V6Z8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_01412</name>
        <name evidence="12" type="ORF">CH63R_12965</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <strain evidence="13">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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            <strain evidence="14">IMI 349063</strain>
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        <text evidence="1">Protein modification; protein ubiquitination.</text>
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    <keyword evidence="4" id="KW-0132">Cell division</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7R0</accession>
    <name>H1V7R0_COLHI</name>
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        <submittedName>
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    <gene>
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        <name evidence="2" type="ORF">CH63R_11295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Rounsley S."/>
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                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Hansen M."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="van der Does H.C."/>
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                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002139">
        <property type="protein sequence ID" value="CCF36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162046.1">
        <property type="nucleotide sequence ID" value="XM_018297230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V981"/>
    <dbReference type="STRING" id="759273.H1V981"/>
    <dbReference type="GeneID" id="28861337"/>
    <dbReference type="KEGG" id="chig:CH63R_02255"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02255"/>
    <dbReference type="eggNOG" id="ENOG502SCD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027976_0_0_1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="40454" checksum="EC3D12B43AD14222" modified="2012-03-21" version="1">MARLPTAFPYAHSTTPEKGAAELSQLLRRLDQTILHADQNRERRLRVSEFERARLNSNLDYARSLLTRVEQEAMHVKLLSRRQDMQADLNRKRELLERLVDRMHDLEQVRRVDPLLHEEDDDNSSDGEDILADIIPTPSESMDSRSTDIPTEDTGDQDEDDEPEAPSLPPPVSALPKEPSQSFAAATTSETENSTSHQPKTTTEAGTTTTQSLRSRGPARPGSPSATTTATARAALFASRRSNTVKSTVSAPASSTATAEAILDHQRAEQDALSESILKMASALKASSQKFSNTLEQDKNVVSRAADGMDKTERSMDAASRRMGTLRRMTEGKGWWGRMMLYAWVYGLMVALILLVFVMPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VA69</accession>
    <name>H1VA69_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_01635</name>
        <name evidence="15" type="ORF">CH63R_04117</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002312">
        <property type="protein sequence ID" value="CCF37122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160338.1">
        <property type="nucleotide sequence ID" value="XM_018299092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA69"/>
    <dbReference type="STRING" id="759273.H1VA69"/>
    <dbReference type="GeneID" id="28863199"/>
    <dbReference type="KEGG" id="chig:CH63R_04117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04117"/>
    <dbReference type="eggNOG" id="KOG4077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099086_0_0_1"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="162" mass="17966" checksum="2CFD0B359F188FDE" modified="2012-03-21" version="1">MSASILRVAARGSTTLFRANPIRQPLVARSGMLLPAIAGVPAANTFSTSSRLRSGDHAEETFEEFSARFEKEFDGVQDVFELQRNLNNAFAYDLVPSPSVVAAALKAARRVNDFATAVRIFEGVKAKVENKGQYEQYLEELKSLREELGVPLKEDIYPEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>H1VA88</accession>
    <name>H1VA88_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="4">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_01638</name>
        <name evidence="18" type="ORF">CH63R_12678</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02002323">
        <property type="protein sequence ID" value="CCF37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152069.1">
        <property type="nucleotide sequence ID" value="XM_018307652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA88"/>
    <dbReference type="STRING" id="759273.H1VA88"/>
    <dbReference type="GeneID" id="28871759"/>
    <dbReference type="KEGG" id="chig:CH63R_12678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12678"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="186"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR03551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="560" mass="60206" checksum="CF080FDFE43430A6" modified="2012-03-21" version="1">MFKSGISSFARAARPSFAATASRRAIRPSTFRLPASSRFASTAGVGDGKIYQVIGAVVDVKFDTAKLPAILNALETTNNDQKLVLEVAQHLGENVVRCIAMDGTEGLVRGRAATDTGAPITIPVGPETLGRIINVTGDPIDERGPIKTDKRLPIHTEPPAFIDQSTTAEVLVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETSVIQLDGESKVALVFGQMNEPPGARARVALTGLTSTYLDNPSLLPSLLLQPPSLLSQLPSILQSPSLIQTECTDNPKFAEYFRDIEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAIDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSKSRMLDPRIVGQDHYDTATRVQQILQEYKSLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFTVAQVFTGIEGKLVDLKETINSFKAILSGEGDNLPEGAFYMVGDFASAKEKGEKILADLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCL8</accession>
    <name>H1VCL8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_09182</name>
        <name evidence="8" type="ORF">CH63R_04824</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002731">
        <property type="protein sequence ID" value="CCF37971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161045.1">
        <property type="nucleotide sequence ID" value="XM_018299799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCL8"/>
    <dbReference type="STRING" id="759273.H1VCL8"/>
    <dbReference type="GeneID" id="28863906"/>
    <dbReference type="KEGG" id="chig:CH63R_04824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04824"/>
    <dbReference type="eggNOG" id="KOG0068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF264">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF37971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="34700" checksum="A705C80A3EEBCF6A" modified="2012-03-21" version="1">MAPSAVSDFPNVSSPGTKPTVYVLDSFQPEVIAFCQENFNVILPGQPKHARWKDAQFLLIRSSRLTAEDIADCPNLLAIGKQGVGIDKIDAEACSSRGIKIFNTPGVNARAVAELVLTLTTAVARQVGVIARQQNSGVVVPKEKCSGLILHRKTVGILGMGNIGKSVAQIFRGAFEADVVAYDPYLPSKAWSDVPHHRAQSVEEVLSTSDVVTVHMPLTPATRDLIGYDQLKSMKRTAIVINTARGGIVNEDGLQRALEEGLIWGAGLDCHQQEPPSRERYGALWEAGAVSTPHIGAATRETQVQTGMAAAVRLLEYATARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDJ6</accession>
    <name>H1VDJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydantoin racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09418</name>
        <name evidence="3" type="ORF">CH63R_08567</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002903">
        <property type="protein sequence ID" value="CCF38299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155564.1">
        <property type="nucleotide sequence ID" value="XM_018303541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDJ6"/>
    <dbReference type="STRING" id="759273.H1VDJ6"/>
    <dbReference type="GeneID" id="28867648"/>
    <dbReference type="KEGG" id="chig:CH63R_08567"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08567"/>
    <dbReference type="eggNOG" id="ENOG502RZ0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053002_1_1_1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
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    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
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    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="264" mass="28807" checksum="75A364D00A9ADF46" modified="2012-03-21" version="1">MTTRVLRRNIRILVINPNSSEDMTRGMERAIQAMPLHDSLEVHTYTAPPESPASIDGDDDIRLSTDVVVRDLVNSGKLDQYDGVLVACYSVHTLVEKLSRQFHASLAVTGIFEASVLTATALLPHSSTASYLSSKWGVVTTGEFWEEHLSRGVTGYLGQRDQSENVKFGGVTSTGLMAGDFHHVSPAEVRAKLELATKRLLGSGDVRCVVMGCAGMAGLEDIIRNSAMDVYGETKGRQVFIVDGVKAGILQLEQTVRSRRLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIV6</accession>
    <name>H1VIV6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_10797</name>
        <name evidence="9" type="ORF">CH63R_11116</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003907">
        <property type="protein sequence ID" value="CCF40159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152931.1">
        <property type="nucleotide sequence ID" value="XM_018306090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIV6"/>
    <dbReference type="STRING" id="759273.H1VIV6"/>
    <dbReference type="GeneID" id="28870197"/>
    <dbReference type="KEGG" id="chig:CH63R_11116"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11116"/>
    <dbReference type="eggNOG" id="ENOG502QTGV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024810_0_1_1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="11"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="494" mass="55692" checksum="ACC1365293259935" modified="2012-03-21" version="1">MSLTHYEIEVVTGLERVGSALSLVGVTLIFITYWKFKRIRSVPNLFIVFASIANVGASVACAIGYEGLRMGETSALCQAQAFLLEMFMQSDPWWSFAMAVNVYLVFFAGANPSSFREYLWVYCAVCFGFPLVPALVCLFLRPHGPNDYIYGNATLWCWINKKWGDLRIFTYYIPIWFCVLGSSVIYFAVGYHVFHHRNQLHNLTFSNNGCDGKEMTCSDERDSAEKVSYLSRTGTRDDCPLVDTRQNLTGRTEFYGTAVTEVQITTMTPKPWTPQPPPVAMTKVTAGDQQPRHQRSWRTSEDDGSPGPRFETTCTSDPPPPKPRLSVFQRIGGVRSKFSSRLQRLDPVKLAYLRTSFIFAISVLVTWTPSSINRVFNMIRRDESHFGLNVASATVLPLQGVWNAVIFFMTSWTVFKEEWKDMRGRHQVRLGSCGEDGLHGGLRIEVLRGDQQDRFKSGRYGHTKTLGSDQTSDIELTPPSGVGNVRAMRGSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ85</accession>
    <name>H1VJ85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZIP Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_10899</name>
        <name evidence="9" type="ORF">CH63R_04775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003989">
        <property type="protein sequence ID" value="CCF40288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160996.1">
        <property type="nucleotide sequence ID" value="XM_018299750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJ85"/>
    <dbReference type="STRING" id="759273.H1VJ85"/>
    <dbReference type="GeneID" id="28863857"/>
    <dbReference type="KEGG" id="chig:CH63R_04775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04775"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555957" evidence="7">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="43111" checksum="6C6C0A44C7EEEB31" modified="2012-03-21" version="1">MARSWKPVFWALFLLVQLGIASSVAEKLGFAGKAVADLSLEELDEQLQQCSVVQSLTADKLSKMSDTPSLLSRAFGVLFPGSPAVNAILATLYISGPPNFLLALCPPNIDPSSLSVMVAFAVGGLMGDTLFHLLPEIFLGEDEPERARLVLVEPNRNLLLGVAILVGFMTFVAMDKGLRIATGGAGHSHDHAGHSHAEAKAEGASSGVEKAGELKSRKKKTDAVSGGDAVERTEKEINPSVKLGGYLNLIADFTHNITDGLAMSASFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKKAAMGAQFVTALGALLGTLIGIAIQELGGSSGEGAMGRNAGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNKMAELRKTLVQFAAIAVGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ87</accession>
    <name>H1VJ87_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_02316</name>
        <name evidence="11" type="ORF">CH63R_04056</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF40290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:sister chromatid biorientation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <end position="612"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="655"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJV4</accession>
    <name>H1VJV4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome subunit RPN7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02371</name>
        <name evidence="5" type="ORF">CH63R_08095</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004123">
        <property type="protein sequence ID" value="CCF40507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157847.1">
        <property type="nucleotide sequence ID" value="XM_018303069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJV4"/>
    <dbReference type="STRING" id="759273.H1VJV4"/>
    <dbReference type="GeneID" id="28867176"/>
    <dbReference type="KEGG" id="chig:CH63R_08095"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08095"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_0_1"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="229"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="489" mass="54221" checksum="7CC78AC14D601DDA" modified="2012-03-21" version="1">MGSEPQYAKYPLLPLAQHVFALTNAYASRPSQQAAAKALNDAITEHKMAPLYRYLAHPLEGILNQVGEGGSQAPGKPLSRKSSLAGMIATKSTPTTVNLPWDEARYQELKADNDRELEEFQKEEDEAVEKAGDTEIQAARGKRAEFWARVGDKDRAIAAYEDVFEKTGILGTKIDLVLAIIRMGLFYGDKLLVKKHVERAKTLVESGGDWDRRNRLKAYEGIYLLTVRSYSLAAPLLLDSLSTFTSYELCTYSSLVVYSVLAGSVSLKRVDFKSKVVDAPEIKAILGDGEDKLLALSGALSAGPGADDTMQDSPPTTAAAKTAVNLTTLGTSTDQPEAEMAIDFSSLAQLVSSLYNGQYKYFFQALAEVEENFLTQDRYLHEHKNWFIREMRLRAYQQLLQSYRVVGLETMATDFGVTVDFLDRDLAKFIAAGRIPCTIDRVSGKGVIETNRPDDKNKQYQDVVRQGDQLITKLQKYGQAVRLRGSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK69</accession>
    <name>H1VK69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_11144</name>
        <name evidence="5" type="ORF">CH63R_09055</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004198">
        <property type="protein sequence ID" value="CCF40622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156052.1">
        <property type="nucleotide sequence ID" value="XM_018304029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VK69"/>
    <dbReference type="STRING" id="759273.H1VK69"/>
    <dbReference type="GeneID" id="28868136"/>
    <dbReference type="KEGG" id="chig:CH63R_09055"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09055"/>
    <dbReference type="eggNOG" id="ENOG502QSE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033932_0_0_1"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="493" mass="55078" checksum="11CA59A60B34AB65" modified="2012-03-21" version="1">MGSIDSTPFPVLDDPRPEDNSLPAFMVSTTRGFLPRADPVAVLPSEFAPLEDILSRMPVKKLDGTPGLLASSTLGETVDAEFPDLTHAIDKYKDNLPLMNALYRDYSFLASAYLLEPCHERFVRGEGYGLARDRLPRSISLPIARCADLTGFKPWMEYAGSYALYNYRLEDPSKGMEYSNVRLIRAFEKGLDPTSSEAGFVLVHIAMVKHTGGLVKGTVDALRSSGSPGSPFDRAGLNRGLSEVLAALRTINNTMETMWDKSRPQSYTSFRTFIFGITSQSMFPNGVVYEGVNNDEPMSFRGESGANDSIVPLMDNLLQVPMPDTPLTEILKDFRSYRPSNHRQFLLHVKDRSLEVGLKNAALAAKLSAEGLAEDEREAIRESRRLWLLILHQVRDFRWRHWCFAREYILKRTSHPTATGGSPIVTWLPNQLEAILVEMEDLYEAVGGGARGDWDLGEELRDVMDLVSRQKQTLRKEVAKYCAERGVGSPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VP56</accession>
    <name>H1VP56_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_02731</name>
        <name evidence="8" type="ORF">CH63R_10977</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005090">
        <property type="protein sequence ID" value="CCF42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155375.1">
        <property type="nucleotide sequence ID" value="XM_018305951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VP56"/>
    <dbReference type="STRING" id="759273.H1VP56"/>
    <dbReference type="GeneID" id="28870058"/>
    <dbReference type="KEGG" id="chig:CH63R_10977"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10977"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052528_0_1_1"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497712" evidence="5">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="279" mass="32450" checksum="E9C34A90AB29045E" modified="2012-03-21" version="1">MRFSLVLPLALLGLTSTVAAAPPQPPRDNNEDFSPALVKREDTKYFHEPCCGEELGHYDIRYFKEAVGYDDHRIVLRNLIRSYLTVTKKLKVETWLAHGTLLGWWWNGKIMPWDYDLDVQVSTATLYWMGQNLNRTEHDYDWTDKDGNAKTERYLLDVNPHGTDKDRGDGQNIIDARWINMANGAFIDITGLAERDPDNSPGVWSCKNYHRYRTTDLFPMRETEFEGVPATIPYSFERILSDEYGSKSLVTTEWLGHKWEPEQKEWIKVPESDDQKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1VV04</accession>
    <name>H1VV04_COLHI</name>
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        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_03225</name>
        <name evidence="12" type="ORF">CH63R_01190</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02006590">
        <property type="protein sequence ID" value="CCF44063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164527.1">
        <property type="nucleotide sequence ID" value="XM_018296165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VV04"/>
    <dbReference type="STRING" id="759273.H1VV04"/>
    <dbReference type="GeneID" id="28860272"/>
    <dbReference type="KEGG" id="chig:CH63R_01190"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01190"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF44063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="52871" checksum="22FE1E672D0B8A7B" modified="2012-03-21" version="1">MAANGSTYSLPVSHKEMLEKSLIDSDPEVAEIMKDEIKRQRESIILIASENVTSRAVFDALGSPMSNKYSEGQPGARYYGGNEHIDQIEILCQNRALKAFNLDSSKWGVNVQCLSGSPANLQVYQAIMPVHGRLMGLDLPHGGHLSHGYQTPQKKISAVSTYFETMPYRVNLDTGIIDYDQLEKNAQLFRPKVLVAGTSAYCRLIDYARMRKIADSVGAYLVVDMAHISGLIAAGVIPSPFEHADIVTTTTHKSLRGPRGAMIFFRKGVRSVDARTGKETLYDLENPINFSVFPGHQGGPHNHTITALAVALKQAASPDFKAYQQKVIDNAKAIENKFKALGHKLVADGTDSHMVLLDLRQFSLDGARVEAVLEQINITCNKNSIPGDKSALTPCGLRIGTPAMTSRGFGEADFERVATYIDESIKICKEVQASLPKEANKLKDFKATVAGGQVAKINDLRQEVAAWSASFPLPVEGWRVDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVP8</accession>
    <name>H1VVP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03297</name>
        <name evidence="3" type="ORF">CH63R_12239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006801">
        <property type="protein sequence ID" value="CCF44308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154054.1">
        <property type="nucleotide sequence ID" value="XM_018307213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVP8"/>
    <dbReference type="GeneID" id="28871320"/>
    <dbReference type="KEGG" id="chig:CH63R_12239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12239"/>
    <dbReference type="eggNOG" id="ENOG502R0CI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658906_0_0_1"/>
    <dbReference type="OrthoDB" id="4835487at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF44308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="46724" checksum="72006CB6E4DC08A8" modified="2012-03-21" version="1">MPHSKANAVEHNRNNCSEVDDKRNEHTAANIKSEDGDSSAINNRTNPRPPQPPAKKCTNPKCKIMTCQGTECKPIAGTKRKNETEDSNPAPAKKDKPLHELIHITASMFNSCQAPLQYWNYPPSTAGRLHKRHWSALDLATRVFNHDLANIVFAWGEKHDIMAMLFQTPTSTQLSGDMSSYTECRRVRDRLKPGDNNTSPVWPTFHEAMIAMLLFANKPPLRWKDCSAWTKLITHLCSYDSGNPTMITVLDELLTAAGRRRLATKTACPADTTATQTAAVTKAATKYQVPDHHQKLFDYALDTAKTNNLRSRLQMRGLAIELDNLGWEDLARYGEKMFDTTVAEDDRKQIRSKLVAELAARMNGDSSTLLPPHYTFTCECGIQTTFQSGVWMPKHKTATTTDDKQATAEKEGIVQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VW28</accession>
    <name>H1VW28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BCL5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_00516</name>
        <name evidence="6" type="ORF">CH63R_14315</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006901">
        <property type="protein sequence ID" value="CCF44439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151607.1">
        <property type="nucleotide sequence ID" value="XM_018309289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VW28"/>
    <dbReference type="GeneID" id="28873396"/>
    <dbReference type="KEGG" id="chig:CH63R_14315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14315"/>
    <dbReference type="eggNOG" id="ENOG502S6KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029797_2_1_1"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF44439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="491" mass="54653" checksum="8CC6AA4044EA126C" modified="2012-03-21" version="1">MEAVRRLLGLPPVGTAPRVDDDHVYPLHVLDDTKMHREIFLNWILVFDDVLDPGQLHRSLARLLELGDWRKIGGRLKLKEDGRLEVHVPQAFTAERPAIAYSHQSVDMDIKDHPIARTLPKVTENVSIQPGAPSFKSFAAPTPATLNEFLNKDIPQLSLRITSFQDATLVALSWPHTLMDVMGQEALLHAWSLVLADRESDVQPVIGAYKDVMTAAISGYNNEEFKLRNKVLRGFSLVKFVLRLVWDKIWNPALKTQTIFVPQRALTELRRQAQMDLCLEYGKPPFVSDGDILAAWLARAVASSLPRPRPMTLVHALNARTRLSSLDAPGVFMQNMVVAAHTLLSADGARGQLGQIALENRRHLMAQSTEGQVLAFLHEQLKDCESGGNPRMLLCTDPDAVLLTFTNWSQAKLFRAADFSPAVVHTAKTVLRGSNNAPGTITTHFVDVVTRSPVRMSWVGVLGKDHGDNYWLSGLLLPSVWAKIEDEIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VW38</accession>
    <name>H1VW38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor CWC21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_00070</name>
        <name evidence="10" type="ORF">CH63R_02373</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006902">
        <property type="protein sequence ID" value="CCF44449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162164.1">
        <property type="nucleotide sequence ID" value="XM_018297348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VW38"/>
    <dbReference type="STRING" id="759273.H1VW38"/>
    <dbReference type="GeneID" id="28861455"/>
    <dbReference type="KEGG" id="chig:CH63R_02373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02373"/>
    <dbReference type="eggNOG" id="KOG1869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067891_2_1_1"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF44449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="20189" checksum="F8B4ACDC8EFAFC32" modified="2012-03-21" version="1">MSDNVGLSTPRGSGTSGYVQRNLAHMRPRDYGAPYPPKDADSFRHKQRQPDKEILEHDRKREVEVKVLDLRDTLEDEGLDEEEVERRCDEMRTKLLAELEKQKNSRGGGAGPVRKHFKSHQVHEMADAKIKESERLRNALRISKDYEEGSHWKRQEERLRGSLEKDTKREDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZR7</accession>
    <name>H1VZR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00573</name>
        <name evidence="8" type="ORF">CH63R_01554</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02008012">
        <property type="protein sequence ID" value="CCF45729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164891.1">
        <property type="nucleotide sequence ID" value="XM_018296529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZR7"/>
    <dbReference type="STRING" id="759273.H1VZR7"/>
    <dbReference type="GeneID" id="28860636"/>
    <dbReference type="KEGG" id="chig:CH63R_01554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01554"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF45729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="420" mass="46276" checksum="03A5117CD3C651C2" modified="2012-03-21" version="1">MSTVTAERMLEVEGQGRVQLSVYSRFKPLQKRVITAIAAFCGFLAQVSTTSVLAAVPEIVATYHTTATAISISNAVYLAFMGLSAFIWGPWADIFGRRSAYLHSLALFLAFTIGTALSPQLELFFVFRAFTAFQGTSFLILGSSCISDIYHPTERATSLGWFLSGTTIGPAFGPLLGGIVVTFTSWRVIFWIQASLAGVALIFVFFCLPETLHKTRESELAGLGVVEKCSKLWKWGNPSRILKLYGNKNFFLVCLASSSLVWNMYSLLTPIRYVLNPRFHLTTPLQSGLLYIAPGVGYVVGSQIGGRWADYTVASWIRKRGIRLPEDRLRSSLVFLGLMLPTSMVLYGWTLDKRFGGIPLPIICMFLQGVAQLAAFPSLNAYILDVMQHQNGEASGKLRIFSPIGTFANHLGDGLDPMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1F0</accession>
    <name>H1W1F0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hexose carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_00604</name>
        <name evidence="11" type="ORF">CH63R_10786</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="protein sequence ID" value="CCF46313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="chig:CH63R_10786"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10786"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Pfam" id="PF00083">
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    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="155"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="188"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="343"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="406"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF46313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06666.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2Y5</accession>
    <name>H1W2Y5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_00641</name>
        <name evidence="10" type="ORF">CH63R_06515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02009123">
        <property type="protein sequence ID" value="CCF46848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159340.1">
        <property type="nucleotide sequence ID" value="XM_018301490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2Y5"/>
    <dbReference type="GeneID" id="28865597"/>
    <dbReference type="KEGG" id="chig:CH63R_06515"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06515"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF46848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="491" mass="53961" checksum="CA7C4AE42F29264C" modified="2012-03-21" version="1">MTAITTPGDASGGATEKGLGSDFDRAESNNGTLAIESLDAAAEQKLLLKLDAYFVPIIMVVYLTCFLDRTNIGNVRVAGMPEDIGASTQEFSTAISIFYATYVAFEPPWTIMMKRITPRVLLTGLCIVWSLSTVFSGFIHNIEGLYAVRLVLGACEAGLFPALNLYLTMVYKREEQAKRVSYLFVCSAIAGAFGGLLAYALLKMDGIAGYAGWRWVFIIEGVVSILIAPILWFGLPNDPSEAYFLTDEEKRMMKVRAAQRAQYMGSDEFSWEEIKIELRDPKLYLSGAIQFCQDILLYGFSTFLPSIIVSMGRTSMEAQYLSIPVFLFGAVAFLSAAYVSDRMLVRGPLVFLANIPGIVGYILIICPTSGGVKFFGTFLCAVAVYNGPGLNLTWLNVNVAPQYRRATAIGMQQAIGNCAGIVAGQIYREAPYLLGNAISVGALGVAQLLVVGKWLYIRHCNEMKRKIASGEMEDKRKVKTGDWELDFHYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>H1W371</accession>
    <name>H1W371_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_15516</name>
        <name evidence="12" type="ORF">CH63R_04280</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009200">
        <property type="protein sequence ID" value="CCF46934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160501.1">
        <property type="nucleotide sequence ID" value="XM_018299255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W371"/>
    <dbReference type="STRING" id="759273.H1W371"/>
    <dbReference type="GeneID" id="28863362"/>
    <dbReference type="KEGG" id="chig:CH63R_04280"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04280"/>
    <dbReference type="eggNOG" id="KOG0425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_1_1_1"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF46934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="225" mass="25663" checksum="B6F1A7F6604A2638" modified="2012-03-21" version="1">MAQKRLMSELQALQKEKWVHIDVDERNVMSWKIGLMVVNPDSAFNGAYLKADMTFPRDYPYAPPTFRFLNKTIYHPNIYTDGKLCISILHTPGEDEQSGEQACERWSPLQGVESVLRSVLLLLDDPEINSPANVDASVLFRDSREEYNKRARETVEKSKKDMPPGVTIPTTADLEPVPQKTMDDDAFWNETDDEGDFDLGGSDSDFDMDEYNEDEDDEDADDDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5G0</accession>
    <name>H1W5G0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04257</name>
        <name evidence="4" type="ORF">CH63R_04668</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02010067">
        <property type="protein sequence ID" value="CCF47724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160889.1">
        <property type="nucleotide sequence ID" value="XM_018299643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5G0"/>
    <dbReference type="GeneID" id="28863750"/>
    <dbReference type="KEGG" id="chig:CH63R_04668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04668"/>
    <dbReference type="HOGENOM" id="CLU_1255899_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="220" mass="25725" checksum="AE305FAAB65C371B" modified="2012-03-21" version="1">MGYPTFSSAQAQGTASDSRHGTQGSVRQVKEVTMLLTNRRDTNIMQARLFVCQRREKERERWTMLTALFIGSTCQMSRSEAEFPLSQTNLTLFHVPRYYFWILPAPTPRSVTSYRRQRWRGHLLKMPNTLYGDRRTHRLTKRRKPKRYPRPRLFPRLWLLRALVASFLYYILFIRWSFWPLLGTGTGIRVESLDCLVELTRGATVGSWDGAGSWDSGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSN8</accession>
    <name>A0A1B7XSN8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151301.1">
        <property type="nucleotide sequence ID" value="XM_018308983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSN8"/>
    <dbReference type="GeneID" id="28873090"/>
    <dbReference type="KEGG" id="chig:CH63R_14009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14009"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="32780" checksum="B47AE9058493659C" modified="2016-11-02" version="1">MATTENPLVRPSIARFDATDPSTTTDTLVNIINRDGGVIVEKLIDRRLAEEIRRDLKPHFDEDIPDKYGFFPATTQRASGLLGISDGCVELACSPLFTSVANALVSSSYTFWRGDQQKTVSGKPIISSTVGFRVNPGGTQQVLHRDDNDYHPHDKTLPVMIGCVTALTKTTAANGATVVIPGSHLWGPDRRPLDSETVPAELEPGDALIFLGNLYHAGGANITQDEYRETVGIFLCQPTLRPAENQFLMVPFEKVKKMKPQAQRLLGYGLCEPGVGFMRYQDPMRVLFGVEDEETVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTP6</accession>
    <name>A0A1B7XTP6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151665.1">
        <property type="nucleotide sequence ID" value="XM_018309347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTP6"/>
    <dbReference type="GeneID" id="28873454"/>
    <dbReference type="KEGG" id="chig:CH63R_14373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14373"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="467" mass="52765" checksum="C1ED73E562C76810" modified="2016-11-02" version="1">MEVAVAVQPVSAIPAPAAAASSAISKDSVSEAQAQVVAANHDNNDADADALYWFRTSGQDLARMMYEANYPDETSNRFLTFYRDVVCPLLGGRPKPDSLPTAVGWDGNPFEYSFEFKGSTKKAGVRFVLDLSEVRPANRDYPLSLATVEKVLDVLSTKSPLYDDHWHRSLERWFVYSHKPSERQRELVAKVGYQTPTILGFDINPKITELAPALLPVMVKSYFPPCFVTEDRGFTRFRSLALGVRQLPDIGSHPNILLGLKMIEDFVADNPQYEGCGRGLSTDFVPAGQARLKVYLRYWGDSFDEIWDYYTLGGRIPIADLEDDKEKLRDLIQLSRGSEYPADKIRPETDAEKKRRAIFGTKPTSLYFSLTPEKPYPIPKLYFYPAFQAPNDEAIAQGIDAWLKRYDWYDGGKTLEQMVANVFDYRRLDEKPGIFTFLGVGRKENGDDSGLSLQVYVTPELYESPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUB7</accession>
    <name>A0A1B7XUB7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151842.1">
        <property type="nucleotide sequence ID" value="XM_018307425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUB7"/>
    <dbReference type="GeneID" id="28871532"/>
    <dbReference type="KEGG" id="chig:CH63R_12451"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12451"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="601" mass="64450" checksum="ACA9687179BAF9FC" modified="2016-11-02" version="1">MAAALHQYDYIFAITAIFAFLDAWNIGANDVANSFATSVSSRSLTMKQAMAVAAVAEFSGAVSVGSRVTDTLRTAIVDPHLYDAEPAVLLLVMTCAVFGSSVFLTLATAHGLPVSTTHSIVGGLVGAATASVGIRNVSWGWNGVSQVFAAWIVAPGLSGALGALLFLGTKRFVLTRTNAVRNAFLTIPFYTFLTFGALTMLVAWKGVQTQVEPTTTQILVAVFSVAGGATLLQAFFLLPYLWRKIVDEDWQLEWTMMWRGPWLLRRPPPPPPPPGVRRVAIKDYYRGHLTADELAHVRASEILLESIQGSQTSSDLFKEDQTDVSLGPAPAPAPAPSPSVPETEAPITSAMSSSRRSSSSSELIPPRPAGPWSSLPVLGWRVNRVLLRGLEKDVITLQRRNAVLSWDIADMHARAPRYDNRAEYMYSALQILTASAASFVHGANDVSNSVGPFVTAYNTWRTGRIGTDDEGNGDGGVPIWILCFGGAAIVLGLLTYGYHVMRNLGNRLTLISPSRGFCMELASAVTVTMATKLALPVSTTQCIAGATVGVGLANGDWKCINPRLVAWIYFGWFITVPVSGLLSGSMMALILNAPHWESHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUH0</accession>
    <name>A0A1B7XUH0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Duf1741 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12538</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151929.1">
        <property type="nucleotide sequence ID" value="XM_018307512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUH0"/>
    <dbReference type="GeneID" id="28871619"/>
    <dbReference type="KEGG" id="chig:CH63R_12538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12538"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="628" mass="70273" checksum="6597DB7D0581DC9F" modified="2016-11-02" version="1">MEASPLTRQPPPEVFQPKIVQLYESLFKDADDDSERSEGFWREFFLLRPDRAALRRILDGLGPADMLALEEHTRELFARAVAAVKNGQGVADLHALDTLSVFLCSALSKKYAHPSSDIINVLAGIDYVDTIFTDFVGALDQIIRGGKSLDLRQKAIEVVLAVTAGAYQTSLLTYFIQRDLFPSVMKFIQDADTTERILGPSTLLGLLANYNKFEFQNPYQMRLNDFVNEATIKKIIRCVGETCQSLTTQYVEVQDDLPEGWTLNGTLHMIGLGVVARGPRPEKKAVYDAETMKHMFTKLPGEEAAVLLATYDFTHANKLFCFNLATLPAEKGEQQPLAAFTSLTSYLLQHAHLSERTTHYSHLNLMVFRLLIEDPVLCKRICSEESKAHVRLCRQRQPFLPLVRGERILAAAVLDTMVDGITHNLRRRLDVGLYTLCVGILLRIVSYLSRSRTRLAYHWADLFRALLNLIKFLTTYVADVKDLPQIDLLLDNVVNLVALSLSAGEGFLPSPAAYDDLFYKVVEAGDGLATFKEGYGLGRRPSNSIDTLISVSTHYKELLAEGGRSGGRKGNLTSVQVTEVIKQGYETLSIQAKEGLDTWDRYREADERTLLKKMARAAVGDVRGMVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVP8</accession>
    <name>A0A1B7XVP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152380.1">
        <property type="nucleotide sequence ID" value="XM_018307963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVP8"/>
    <dbReference type="GeneID" id="28872070"/>
    <dbReference type="KEGG" id="chig:CH63R_12989"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12989"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="28692" checksum="B56141C2DC6769A9" modified="2016-11-02" version="1">MASTLTPIATPALLASIRSRPHVPKHAWYFVAATTLAILNRPDEIPQVYQHVMTHGVGPEDIKPDPDEQREILRKLREALIKASAVGGMPKTINSLMELKKVTPQHLLDEPRESDSHITSSPTARHVDMYETPPSEVLQRGHDFWNLIYGKISKRILSQMDRCGTEDLGLTVRLMYGHILSNTNVLSPVETSYVLIAGLIPQDVNPQLKGHLRGAINGGASVEEVRAVRGIVMDICEASGMRRLSDDGSGGLGWRSEVATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWF0</accession>
    <name>A0A1B7XWF0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH63R_13213</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152604.1">
        <property type="nucleotide sequence ID" value="XM_018308187.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28872294"/>
    <dbReference type="KEGG" id="chig:CH63R_13213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13213"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="829"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1653"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="683"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="955"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1840"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="620"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="401"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1849"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1920"/>
            <end position="1935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1945" mass="219745" checksum="EBB16B635B3056E7" modified="2016-11-02" version="1">MDHPKDFRSTVLQAPSRHDDRDRERERDRDRDNDRDRRHHRDIMNPTPGSTRHSGFSLRSPTQSEYHHPHHSAYSSPKAAPSHSLPHHSPRSHQSGLSHPNSYPSSSTTSTGPLAPTLPALGGGGGGGGGSGSGSSSGAGHHQAPPLSPLHPPSGYYPPPESHQTRDKPTTGSYYDPLTDTTRERRISDAGWSGNAAKGSPKTARDPYGNYSQQQPAEPVSRDSHAYYKNGGGASAGYTSPSAANFPPRSPRSHSHSHSHSHQPPAGSISPSNRATPHMTSPSLRHAASPSVHAASNGGPVTSLPPLGKPEPSTLKAPASVRTILAGHPERRRRPDTLQTPSRSADPMSFSNILSSAEPVSKPKSKSPPPARDEKVAEKVAEKDAEEDSKPHQKPAPKPAPKPDREKPRSTEPPVKTERSEREAEIELRPEPAKERLSTPLARKERKERVPRKSKSRASDIRDAESTPKTSRRSSSKLEVHTPRIPSKRQANGQPKQKTLSAEKEKKVMDLIAQLDADADDLTDSDLAAERAQYQESGNKRRRLMQEKDGNRNVDRREDFSTEIGRRLGALADLGKRRYDDIYYEEAMNEVRERELFAEKERKKDMQRKRRREKSMAVTMEQQKLALERARLAEDETEKAKHLRDAERANKKALQTKLILQKGIKGPARNLVELNLDGGTMATFQASDMEPGTKPKSKGRSGPRPKKSKEQKQAEKDAAEAAQAAIDAGEELPVKEESKIRIKFSKKSKDKDKEKDKNKDKDQDEPDVEVEGDIEAEVDDDTIVEPVKEKKEKKGKKKDKEKKEEKPEEPPNKDAKFETKGFLQIYDQIWRDLARKDVSKTYKMAAESYQTKASNLKKTAILASKEAKRWQLRTNKGTKDQQARAKRVMRDMMGFWKRNEREERDLRKAAEKQEIENARKEEAEREAARQKRKLNFLISQTELYSHFIGKKIKTDEVERSTDNPEIAAENKVDSGHNKNFDIVEPTGPVGAKVTDFENLTFEEEDEETLRQAAMANAQNAIAEAQRKARQFNEPDGPDMDEEGEMNFQNPAGMGDVAIEQPKLINAQLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVMAYLAEKYDIWGPFLVVAPASTLHNWEQEIRKFVPEFKILPYWGSAGDRKVLRKFWDRKHTTYKKDASFHVCVTSYQLVVSDVAYFQKMKWQYMILDEAQAIKSSQSSRWKSLLNFHCRNRLLLTGTPIQNNMQELWALLHFIMPSLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQKELGDKIEEDVYCDLTYRQRAIYSNLRNQISIMDLIEKATTGDNDDSGTLMNLVMQFRKVCNHPDLFERADTSSPFSFGYFAETASFVREGSMVPVAYSTRNLVEYELPRLVWREGGRLYKTGRDNLAAGWRNKSLQHMMNIFTPEHVRDSLEGSDAFSFLRFADASPAEVYKASHEDVFTRAVELSQKKDRLSLFNVAYDEPEDINFTPAHTLFNITARNNRKPLTEITQEGLLANLMNVAREEYDTSGLGRLEPAGRPRATAPPIEVSCCSRGTALETESILFNVGMRKSLFGPSIHEERAMVTEKIPLERFPPRKLLPAPDNEKKKFNNIAVPSMRRFVTDSGKLATLDKLLTKLKAEGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQTRPEIFIFLLSTRAGGLGINLTSADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLITKGTIEERIRKRAMQKEEVQRVVIQGGGASVDFSGRRAPENRNRDIAMWLADDEQAELIEQRERELLESGELEKPQKKKPTKRKRVVNEDISLDEMYHEGELQPASHGPDDGTNQLTGEGNFDDNRGGAAGTSGTATPVAEPDAKGSKKRRTGGGKKAKTLKQRLAVADGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWG7</accession>
    <name>A0A1B7XWG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152624.1">
        <property type="nucleotide sequence ID" value="XM_018308207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWG7"/>
    <dbReference type="GeneID" id="28872314"/>
    <dbReference type="KEGG" id="chig:CH63R_13233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13233"/>
    <dbReference type="OrthoDB" id="4845689at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601127" evidence="2">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="152" mass="16201" checksum="6A1E1C23B6F914F0" modified="2016-11-02" version="1">MRFTNILTAFSCIASALAAKYILVLNPTTDIESFSAKLAQDSIVVVSKFPLFNILVVQTYIHDIAALESYPEVSDAEVDQIVTIGPVIPPVPLPSPLPDSEEPEVPPVPLPSPLPESEEPEVPPVPLPSPLPGSEEPEVPPVPLPSPLPDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX91</accession>
    <name>A0A1B7XX91_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_11089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152904.1">
        <property type="nucleotide sequence ID" value="XM_018306063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX91"/>
    <dbReference type="GeneID" id="28870170"/>
    <dbReference type="KEGG" id="chig:CH63R_11089"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11089"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="100"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR04386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="597" mass="64284" checksum="8DD73415C0DF33CB" modified="2016-11-02" version="1">MFDAQKASGPFLTSTTTPAFLESRASTLASSESSYDEMEKELTIPSSAASLQDIHIDAVPSASDLCNDPARTHPIKSEKSTTVSDEEKTNYPGGMKLSLIIAAACFSVFLMALDNCIIATAIPRITDEFNSLEDVGWYGSAYLLTTASLQLLCGKLYSFFSIKWIYLIAIGIFELGSLICGIAPNSITLILGRAIAGLGSAGIFSGALIILAYSVPLEKRPIYTGIVSSMWGISSVAGPLLGGFFTDSMTWRWCFYINLPIGAATVVVIMLFFPDPERFVPQHDWRTRLVQIDPLGNLLFMPAVICLLLALHWGGVTYPWTSARILVLFAVFAIGMLGFLFLQYIGQENATVPPRIFKKRTVWSSSFFSFTLGAAFLLSVYYLPIWFQAVQGVSAVESGVRSLPMLVGNLIFSLVAGAAVTTWGYYTPFMMLSSVLMCVGYGLISTFSPDTSSAMWIGYQIIAGAGVGVGMQQPLIAVQVVLDMVDVPTGTAIIIFTQQIGGAIFVAIGQTVFTNQLVERLVQHVPDIDPHSVIAAGVTAIRKTVDAEFLPAVARAYSDALTQTFLVSAVTASATIIGAVFVEWKSVKGKTIQATMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXH4</accession>
    <name>A0A1B7XXH4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152995.1">
        <property type="nucleotide sequence ID" value="XM_018306154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXH4"/>
    <dbReference type="GeneID" id="28870261"/>
    <dbReference type="KEGG" id="chig:CH63R_11180"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11180"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="565" mass="61628" checksum="3CB2763011D32D60" modified="2016-11-02" version="1">MDEAISNFVAITAATPEAARGFLEMTNNNIEQAIQLFFESPDLQNSFNSAPAATSSTAPPVPSSTRPNAGRQDERGVIHIDSDDDEDTAMTVDDMDDNFGHDDSDIAAHAQVEAIARNAQEEEDAAMAKRLQEELYGGGGVGGGGGGGGVGGGFGGGQDDVRSPIARTTETLVGGYEGDDGMDLDTIIRAQMRQREAARAARGGAANPFNHNLSIWDDDGPTPPQQPAQAASNEGGSRAQRLAELFRPPYDIMSRLDWDEARQEGKDEKKWILVNLQDMSDFNCQALNRDIWKDEAIRHLLEESFIFLQYDRTAMAAQQYINFYFHGHGHENPENYPHVAIIDPRTGEQVKVWSGRPFPSASDFHAQLAEFLDRYSLAANSKNPVVDQAAPRPKTIDVDRMTEEEMLEMALQNSLAASNGGSGSGSGSSSSKPTSNVIDPDALTKSESPKVEAAEAEAASASASQSIWTKIASDKPHTEPENNPATTTRIQFRHPTGRVIRRFTLDDSVRRIYEWLKSEPLEGKGGVEFELKRMPQGQDLTQDLDKTILEAGLKQGTVMIEFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYC6</accession>
    <name>A0A1B7XYC6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153270.1">
        <property type="nucleotide sequence ID" value="XM_018306429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYC6"/>
    <dbReference type="GeneID" id="28870536"/>
    <dbReference type="KEGG" id="chig:CH63R_11455"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11455"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="443" mass="49737" checksum="B6F17B5DDE4C4425" modified="2016-11-02" version="1">MRSSLSCESCRRSKIRCVNSGTPPCTKCEKSGKLDCTLTRPQVPPTRRAARRARRATEEAPSTSYSHDVDSQRLLVSAPQSRGPATPSSGLEHRDGREEMEGHLEQIPKDVVFIALEAFWRKFPELRVIHPSSFMESFGSTCPRESKALLATVLAMTKTQKPDSDRLRTQILFPSERYASYACDVLAACILQPPDVKVIQALLILTLYEWGTRDFHKAWMHCGEMVPEPQDLTILLTPRAGIAIRMMQLLHSSRVAPFPLEIPRRSEPNSLTPAIETRTFWACFIMDCMVSSGTYNPRVLPKPEMRKLNVPRPPTSTEFALGAGSSGQPEPSGEDDAAPYPPANSSVYLDLDRGFGIMADGFDIYSDIMAFVFNDGRKAPGMCLPENCPWAPTSPVACWRRRLEEWRLKQHPRLHYPDNSVAAHATLGYGESFVYLNLLYYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYH7</accession>
    <name>A0A1B7XYH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153333.1">
        <property type="nucleotide sequence ID" value="XM_018306492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYH7"/>
    <dbReference type="GeneID" id="28870599"/>
    <dbReference type="KEGG" id="chig:CH63R_11518"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11518"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="602" mass="65611" checksum="2646BB043B715E70" modified="2016-11-02" version="1">MSAINPASAPQASKQSQATGEHDVEKNSAQDVVDIHADPLKPESDDSSEHKQEGVKKVEAITTVWSPKMLWVVFALLYLVSFSDGLLQSVQSNLTPYVTSAFGQHGLLATTSIVSTILGGVSKLTIAKIIDIRGRAEGFIGMVFLVIIGMIMKATCQNVETYAAAQTIFWVGHLGLIYIITIVLADMTSLKNRMTMIALNGTPTIATTFAGPKIAQLFYDQVNFRWAFGAFAIILIGFSAPVAVIFFFSEVKAKKAGLIAPKQKTRSSFESFKHYFVEFDILILNHEVVGLILVMAGWSMLLLPFSLVSNATHQWESPTIICLIIFGVVSLVLFAVWERYFAKVSLFPYQFLKDRTVLGACLVYGIMFASVYCWDSYYQSYLQVAHNQDITSSGYILNAFSLTSAIISPFIGVAIRYTGRFKYIALAGVPICVLGTALLIHFRTPSTSVGYLVMCQIFNGVASGIFSICSQIAIMSSVTHQQIAVALALHGLFGSIGAAIGLAIAGGIWNNVLKNAIRQQLPAESKDLTASIFASITTQLSYPMGSPIRTAIIAAYADVQRKMVIAGCAFIPLIFLSLLLWRNINVKTVEEEKGKQTKGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYR7</accession>
    <name>A0A1B7XYR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153410.1">
        <property type="nucleotide sequence ID" value="XM_018306569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYR7"/>
    <dbReference type="GeneID" id="28870676"/>
    <dbReference type="KEGG" id="chig:CH63R_11595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11595"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="507" mass="55905" checksum="8E43CD8D0F17CF46" modified="2016-11-02" version="1">MDPQSQTLAPLPDVLRRGLTAVSFFGFLSFVTTTALFFVLTYRLLSWYFAPAPGRPQRMADEPNADAVLAEEMGLPETMYSAGGKTSNSRTKRDAPNQFLMLIYNLLLADIQQALAFLLNASWLSRNAIVVESTTCWAQGWFISTGDLASSAFITTIAVHTYLSVVRDYKLPTWAFWTMIGSVWFFIYALAVAGIIITNNGAADGGLYVRAAAWCWVNVRYEAMRLYLHYLWMFVSFFITAALYVLIFNHIRRTNPALQLPSSSNNTTSSASKSNRGRRLSHAHTLSQSGHQKSSHGEAPAANPSSAGHHPAFLIYPIIYILCTAPLALGRVITMAGKQVSLEYFCLAGAMIASNGWLDVLLFSTTRHVIIFNASPDYEETGLETFAFMRTPANRRYGNMVWVQGAGSAPQNLTADEGTGGWLSKLFRGGRRHGADTKRDRHRSGAHRSISQESLRRRGGNMEGIQMETVTTVVVEMDGQPGGKKAAGRPHSVDTIEKERAQSFGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZT9</accession>
    <name>A0A1B7XZT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153797.1">
        <property type="nucleotide sequence ID" value="XM_018306956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZT9"/>
    <dbReference type="GeneID" id="28871063"/>
    <dbReference type="KEGG" id="chig:CH63R_11982"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11982"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="53921" checksum="52BFDC82285755AF" modified="2016-11-02" version="1">MGFKVIIVGGSISGLSLANMLERFGIDYVLLEGHSVIAPQLGASIGLLPAGLRILDQLGCYETIRELAGNTYYTASMRLFSGKIWKDTQPVTFSEKLEERVGYPQIFVDRKTVIQVLFDKLQHKDRVLTDKRVNLIELVQDRVNVHTKDGSVYTGDIVVGADGVHSAVRGEMWRIAQEEKSDHFKPDELSGLQCESKCIFGISKRPDCLPASPAQMNAFFKNGNYMILTAPGDRLYWFLFTEAERTRGGDIPRYTKEEERELAELHFGDRVTETMTFRDVYENRLQTTLASMEDHVFRRWHYRRIITIGDAAHKVHPISAQGGNGAMETAAVLVNALRRELEKTHSEGRAELAEADIEAVFAEAQEKRFGRAEGAVSQGRHTNSASIKETLFSKVFVDYFFPRYGQSLIFSLIVKNTASGPVVEGIPVPPRYEAAVARHEAAQKGKGPSWTLWSMLTLGAGLLTAVCYSALGPAWPGLSLAWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y269</accession>
    <name>A0A1B7Y269_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154617.1">
        <property type="nucleotide sequence ID" value="XM_018305193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y269"/>
    <dbReference type="GeneID" id="28869300"/>
    <dbReference type="KEGG" id="chig:CH63R_10219"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10219"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="322" mass="34942" checksum="1948CA1D13B2AE4B" modified="2016-11-02" version="1">MAPSVDPAIIEALDLNPEQTKIASHGASGFASSFKLTSVIDGHPTNFFVKMGSGKDAEIMFRGEHESLNAIHNAVPDFCPKSYAHGEYQSSPGKHFMVTDFLDLGSSAPGGSSLSLAAKLAKLHTTPAPIPEGFDKPMYGFPATTCCGSTPQDNSWKESWAEFYAENRLRSILRAGIKSNGSDGELSKAVETVASRVVPRLIGDDHVRGMKPVVVHGDLWSGNHGRGRIGGKGGAEEVVYDSSAVYGHSEYELGIMNMFGGFGGTFWNEYNKLVPKAEPKEEWEDRVALYELYHHLNHYAMFGGGYRSGAMGIMKKLISRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2A1</accession>
    <name>A0A1B7Y2A1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HSF-type DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154669.1">
        <property type="nucleotide sequence ID" value="XM_018305245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2A1"/>
    <dbReference type="GeneID" id="28869352"/>
    <dbReference type="KEGG" id="chig:CH63R_10271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10271"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="743" mass="80429" checksum="1AF07D4582F3C6B8" modified="2016-11-02" version="1">MHIPMSLNPRKRPAPESTPAMPMPQVQQPTFPSPTGDPFLRWGGAADANGLVDGTGAQAINSYGIVPGPQQQQFVPPTPNPNNALARRQMNRALVPTGVRQNFDSPSDPWSLGGEDSALLQQQANGTMTETDNIEVLEEMARKAMREAQQKRKQIPPFVQKLSSFLDDDKNSDLIRWSEKGDSFVVLDEDEFAKKLIPDLFKHNNYASFVRQLNMYGFHKRVGLSDNSMRASERKNKSPSEYSNPFFRRGHPNLLWLINKPKGGNKGKKGGKNAEVEGDSEEDIVVTDDAMGQGFGATSAPASKALPSPSDMPLQKKEMVLIREELAKVREQQRMIMTAIQRIQQDNSALYQQAVVFQSQHDRHQNSINAILNFLANVFRKTLEDQAGPQSVNDLLASIIPNGNNATSVPQGSVVDLGDYVQAAQNSASNSKNNMNLAKRRHAILPPIPNGRANTVSPSPVSASSTPQPYSREMGTVTELFDTPPGDHTSPSNYLAQELETNPHESMMKIIHNTNANNSSGIDLPEVVNNTPATMSNDQRNMMLNAMAGRSATPSTNAPRSAKPSVSASPNPPAPSVTATPETPPMPAASGLSLSPIMGSAAPPPSLQQINFNQEDLAALHRMQEEQAAKLDHLSSMLGPLSPSGRIPGIEEAGNANGYFDGDLDIDQFLNTDAFQGDNAYPGVNFNGDGDDFNFTLDGSGINQGGTNVNSTPSSSGTEEIPRENFDGLSGSPDRGNKRRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2U2</accession>
    <name>A0A1B7Y2U2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154846.1">
        <property type="nucleotide sequence ID" value="XM_018305422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2U2"/>
    <dbReference type="GeneID" id="28869529"/>
    <dbReference type="KEGG" id="chig:CH63R_10448"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10448"/>
    <dbReference type="OrthoDB" id="4851641at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="255" mass="26583" checksum="8009836BF8B3F034" modified="2016-11-02" version="1">MAGLQPGAGTPLSASSSAPLLGRTGAGTGTPNTLSGATGAQSETGGTNRLITAIIIIIVCAAREAKHADSLTKTDAITTTTTRALELRPPSHHVRHLIDAPALPPSATSLPVVLPSSPPAVLTPSPTPSFIPPPPPVIPESSLPPTTPTPTPTPTPLPGGIASPSQAETSGGGNGVKLMPALPIALGSVGGVLIFGLIIGMLYRKGRWPFHRRRHFAEIDELEVERQQELERQNKMKWDPRVTRAYRTQDAGVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2W8</accession>
    <name>A0A1B7Y2W8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154876.1">
        <property type="nucleotide sequence ID" value="XM_018305452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2W8"/>
    <dbReference type="GeneID" id="28869559"/>
    <dbReference type="KEGG" id="chig:CH63R_10478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10478"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="339" mass="37427" checksum="5CB5D01C5D5E6E6F" modified="2016-11-02" version="1">MSNELASQAGWESNPLSFLYRQAVITPAEIPDEFDLSECTLIMTGASSGLGLEASRQFLERSLGHLIMGVRNTAKGEALAEGLRREFPMARIQVWHLEMESYESVRAFAARCRKDLARIDIVILNAATIAQSFIRAREGRELMLQVNYLSTALLALLLLPAMKEKRPPGEPARLVLVSSDFTYWHEPEEDMVTGSLFKPADSEKLWESGKNYQQSKFLGQLFVAKLATFINPNEIIVNLSNSGLTGGTNIVKPASQSFFMGLVKKTLGRSVEVGARSYLDAAIVKGKESHGSFTSDGVIKPWPAVMYTTEGTGLKDRLWAETKKEPGFAEAFAEIEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3C6</accession>
    <name>A0A1B7Y3C6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154983.1">
        <property type="nucleotide sequence ID" value="XM_018305559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3C6"/>
    <dbReference type="GeneID" id="28869666"/>
    <dbReference type="KEGG" id="chig:CH63R_10585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10585"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="264" mass="27994" checksum="12631F0550594E2C" modified="2016-11-02" version="1">MLQSSSSRDSPLTSHGVLQARRLGAHLATRTASASAGITHIFSSTLRRASTTAAAVREAVASSHHSAARDIEVVRLSDLREKHFGTGEGQKFGGTTASGAARPRHDGAEDLDAMRMRAKRFVDGYLAPIFACVEAEPGGAAESIVIVAHGIILGVLSSVLCSPGLFAAVDPDSESQRPWSWSNTGFVEIRITSMPVASDLARASLDALPAVRWPHLSLQTVAVNCTEHLAGLKKTRGGIGSAKFDEKQKTIISFFAPASRKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3C9</accession>
    <name>A0A1B7Y3C9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_10649</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155047.1">
        <property type="nucleotide sequence ID" value="XM_018305623.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28869730"/>
    <dbReference type="KEGG" id="chig:CH63R_10649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10649"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="10"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="941"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2469"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="941"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1096"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2554" mass="278722" checksum="A69208193B1B752B" modified="2016-11-02" version="1">MSTSSQAFVHSPVAIVGMGCRFSGDSTSPQKLWELLEQGRSTWSKIPTSRFNVGGVFHPDGQRVGSTHVKGGHFLDEDPALFDASFFNMTSEVARDMDPHHRLMLEVVYEALESAGIPLESAAGTNTAVFGGIMYKDYHDSLNRDPKSLPRYFITGNAGAMVANRISHFFDLRGPSVTIDTACSTTLTALHLACQSLRAGESDMAVVVGANLMLNSDVFVTMSNLGFLSPDGISYAFDSRANGYGRGEGVAAIVLKALPKALADHDPVRTIIRETALNQDGKTPAITAPSDMAQEQLIRECYNRAGIDTSQTSYIEAHGTGTPTGDPLEISAISRAFQGQPLHVGSVKANIGHTEAASGLAGIIKVALSLEKGLMPPSPRFLRPNKKLMLKEKNIKARLLSSAQPWPLKDGIRRASVNNFGFGGSNAHVILEWHNPDSQDQEQTNGSATVDAASGPARIYILSAKDEPASKRMISNLRNYIENADSTQERNLLASLAYTLGSRRSALPWKTVFAADSLDGILSSLDGGQNQPERSRKEIRVGWVFSGQGAQWHAMGRELFEAYPVFKTAIRECDSYIKEMGATWTITDELHRDEETTRVNDAEFSLPLSTAIQIAVVRLFWSWGIRPTGITSHSSGEAAAAFAAGVLSARSAIGITYIRGALTRKGKSTSGPKGGMMAVGLGRSEADDYISRVIGDNKAKHLVVGCVNSPSSVTVSGDLPAVAELEQLLHADKVFARKLKVTEAFHSSHMKPMAAEFATLLVGLLEANDVDLTTTPSSMVYSSPKTGKRMSSLESLLVPSHWTESMLQAVEFESSFIEMCWDPKTKEQCVDVVVEIGPHGALGGPITQIMQKPELGGASVSYLSSLSRGKCAVGTTQGVAMALMRQGYRLEMDAINFPHGRDDTNVKVLHDLPTYSWSHQLRYWREPRNSRALRQNEHPPHHLIGSRDPLSPFSAPTWTNTLRMSDIPWVRDHVVGSDIVFPGAGFISMAIDAMSQAHQPNPDEKTFFNLRDVDLMQALVLPVDAELDVDLRLAIRPCDEKSLGVKGWYAFSVHSISGEKNTWTEHCTGLIRIEKHDRTSWDAPDLPALKMMDAAVYSRKTDPKILWESLHETGIRHGPIFQNISQIQSSGRLSLCTFQVADTASIMPCSYESQHIVHPTTLDSAIQAAYSPLVSTGKRLKAALVPRRLKKLKVASTLFNFGAGSVLGAQVCLKKQSSQSFSADLAVFDGVTGDDNPSTPDVLIEIEGLSFQSLGVSLSGKSMDSDGGGDTRSSWSWAPDITLLDSGRLSSQLSAEAEPREKDLMMDLRRCTIHFITEAMEQLMTDDIDRLDGHWKKFHHWMTAQLALTREDRLGPDSSSWLLDDAEHKASVRARVLEGGVNGEMITRLGPQLLPMLRGQVEPLELMMEGRLLSRYYVEALKWKRSNTQASELIKLLAHKNPRCRILEVGGGTGGCTELILSALGDSKPVDRYDFTDVSAGFFEPARERFADWQDVMTYSTLDIEKDPASQGFECASYDIVVACQVLHATTNMRRTLSNVRKLLKPGGKLVLVETTNDQLDLFFTFGLLPGWWLSEEEERQLTPSLTPGLWRTMLSASGFNGVELEVRDCNDTDFYMISTIMSSATVEPVTADRDSSSDAVLVYGDRPPPSEWLTDLQLSVAGATTIGSAPSITSLDEADVAGKTVIFLGEVQQNLLSSIETDTFARVKSMLMDSRAVIWVARGATMACDDPRKALHVGLLRTLRNETNGKPCISLDIDPSRDPWTPETIDAILQVFHTSLGAANQHSDFEYVERDGIIHVPRAVNNPGWRDSDTAEATLKPFKSSPGSRLRMHVERPGLLDSLCFREEEIPDLPADWVEIEPVTFGLNFTDIMVAMGQIKQDPEPFMGFECAGVITMLGEAAAAERGLKVGDRVCALQRGHWATRVQTPSTNVVLIPSGMSFEDAASIPQAFATAYISLFTTANLRKGERVLIHSGAGGVGQAAIMLSQLAGAEVFVTAGTQAKRDFVCRKFGISQDHVYSSRDASFVDGIRERTGGEGVDVALNSLAGHLLQATFDCMAEFGRFVEIGQKDLEQDSRLSMHTFMRNVSFQCVDLLAWERAKGDAVQEALKHIMKLLEEKQLGLIDPVSAYPISDIEKVFRTMQGGQHVGKLVVTASEKDLVPVHGGASPLRLRPDASYLVVGGLGGIGRRICEWLADHGARNLIIVSRSSAERNPFVTSLEQRGCVVLHHACDVADEGQLATMLRRREQVKMPPIRGVLQCAMVLRDALFTQMTADDFNAALRPKVQGSWNLHETVAQDVDFFVMLSSLVGVMGGAGQANYAAASAFQDALAQHRRAQGKPATTIDLGMVKSMGYVAEAGQSISERLVRIGYKALHEEDVLLLLEKAILSPSPPSSSSDPSQGVVVTGINTSRGSHWSESRWIQEARFAGLKYREAPVQGSRVAGSSSQQGHDDIRGELGRAASYDEAMGVVLREMSRKLMRMFGLAEDDMSASKSLTSIGVDSLVAIELRTWITSQLNVDVPIFELMEGNTVTGLAEVVVRKLGHVKADQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4V8</accession>
    <name>A0A1B7Y4V8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155568.1">
        <property type="nucleotide sequence ID" value="XM_018303545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4V8"/>
    <dbReference type="GeneID" id="28867652"/>
    <dbReference type="KEGG" id="chig:CH63R_08571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08571"/>
    <dbReference type="OrthoDB" id="4832888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="130" mass="14859" checksum="B41C086A6FE013F9" modified="2016-11-02" version="1">MVLLEMTTYLILLILTFFRFLLDRGYYLLIRDLGFIIVILLAWFPNMVAGMLIRYCVIPVFSWLGFGPRGSIVGEAFLSGAFVNPREGFIGRIGPETWARYGDFVEVPELIAYMQSLALLWHFEEDGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y553</accession>
    <name>A0A1B7Y553_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155643.1">
        <property type="nucleotide sequence ID" value="XM_018303620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y553"/>
    <dbReference type="GeneID" id="28867727"/>
    <dbReference type="KEGG" id="chig:CH63R_08646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08646"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601345" evidence="1">
        <location>
            <begin position="23"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="56561" checksum="BB302C6D76D48952" modified="2016-11-02" version="1">MVRSALLLTVTAALGLGHLASAQNSTADPWPWQTYRSEPALQPPSLKITQTGEVAEGHLFFDQSGSGAHNYSVFIMSNDNELIWEGPYGDVSAWRAQTLDGEPVLTMYTGITMPEPYGFGYGAVFIYDQTYRNIYNVTLARHKDGLNLQTFAGWDASGLADGSWIDMHEDLITPRGTMYVPANNVTQADLTSVGGPADGWVVDSLFFEMDIKTNEILFRWSHLDHLDEIPLADSAAVYPLGDLGRNQTYPWGPFHINSIERFADGGFLVSSRYYCSIFKIAQDGSVEWTLNGRTGGSFALKNGLSFCYQHDARIHSEGNGTALISLFNNDNSGVASGVNETSGILLTVNTATWEAALQRELIDPSDAIFAVSQGNVQVLDDGSGHVVVGYGSTPKIKEFDAAGECVFTAQFGADRLVQSYRGHRYPWVGRPHYAPKAFACGAGNNRTEVYMSWNGATENERWTVFGGASEDVLEEKAAVDKTGFETKASFAGSARFVRVESSGKGIETGMSEVVAVEGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y769</accession>
    <name>A0A1B7Y769_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial export protein Som1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156431.1">
        <property type="nucleotide sequence ID" value="XM_018304408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y769"/>
    <dbReference type="GeneID" id="28868515"/>
    <dbReference type="KEGG" id="chig:CH63R_09434"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09434"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13726" checksum="CFE4C2B609412DBB" modified="2016-11-02" version="1">MAPPCNVFPVSKLELHVQADVKGKKRKLPGGADVDLTKCALKEMTQYRCFIDDPKSRDSPVRCWPIHRLFRQCQDKKGTFTVETTAWEGSSSNTHQSPPTTGGHKLDGGHHDVPSYHEWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y794</accession>
    <name>A0A1B7Y794_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cellulase</fullName>
            <ecNumber evidence="3 9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_09420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 45 (cellulase K) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3 9"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156417.1">
        <property type="nucleotide sequence ID" value="XM_018304394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y794"/>
    <dbReference type="GeneID" id="28868501"/>
    <dbReference type="KEGG" id="chig:CH63R_09420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09420"/>
    <dbReference type="OrthoDB" id="10035502at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052288">
        <property type="entry name" value="GH45_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000334">
        <property type="entry name" value="Glyco_hydro_45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39730:SF1">
        <property type="entry name" value="ENDOGLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02015">
        <property type="entry name" value="Glyco_hydro_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01140">
        <property type="entry name" value="GLYCOSYL_HYDROL_F45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601390" description="Cellulase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 45 active site" evidence="12">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="379" mass="41470" checksum="7F8796D5CDAC3BF8" modified="2016-11-02" version="1">MRSVTVSSLVVFIHLLTATLAASGAGKSTRYWDCCKPSCAWQQKASVNRPVLTCDKNDLPLDPDAKSGCESGGSAYTCTNQAPWAVNDLVSFGFAATAISGGTEASWCCGCYAITFTSGKNKGKIMVVQSTNTGGDLGSNHFDIMMPGGGLGIFDGCTSEFGFQFPGARYGGVSSRSECSFLPAKLQNGCQWRFDWFMNADNPSLSFTQVQCPSELVARSGCRRSDDASFPAFQMPTNTKWEPPQPTETAGPHEQLLAMRSRHQSHGVVVVVEFKSIFDDDDDDDDNDKRKPAGLHYGDFSSDLNQQPHILHIQLRISHIHDKVRPGGGDGIRLGSVQRQLLAHAFSMRRWCGLRVVEPVLLAVPAYWTMRWTRIQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8D9</accession>
    <name>A0A1B7Y8D9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156703.1">
        <property type="nucleotide sequence ID" value="XM_018301925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8D9"/>
    <dbReference type="GeneID" id="28866032"/>
    <dbReference type="KEGG" id="chig:CH63R_06950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06950"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="309" mass="35166" checksum="3FAD0A930D14658A" modified="2016-11-02" version="1">MNGVARPSEHDAGRAIRSTQSPLEFELMVKNPVAYPALRHVPLTTLERDGLLRPSRLRRSKSVDYQYNGLRQHPSPNSKSTAKLMDGLPIYENDDEDDDDDDDDDNNNDMFHLDAPSSRTSDESRYPVPFLCDERLRDLKISYWTDVSVTDDYAARVISLYLVTDHPLLGVFDPHLFISDLVGQRQTYCSRLLVNALMYWGCQMYTAIDHDAVHLAESFCKEAERLWVLEKNNTTILNAASAQLLSLAYLGHGKDHYVLKYLAAALQIGTRMSLFGIETTKALEEMERLSPQTRRANSYTAWGIFNWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8M3</accession>
    <name>A0A1B7Y8M3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CNH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_07188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156941.1">
        <property type="nucleotide sequence ID" value="XM_018302163.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28866270"/>
    <dbReference type="KEGG" id="chig:CH63R_07188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07188"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="860"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1321"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1630"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1632"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1682" mass="185623" checksum="AFEF0ACA4C0C036D" modified="2016-11-02" version="1">MSFRGDGQRRYGHTPPVQYPTPEQSQDQSAYLGRRPSFNNGDDAAMFDQTRAQSRGHQPSGSRGEDELFLTSPTSSSHSGGRHSYGSTNNALSGYQHQYQASSPPTSSHSSYNPQAFARTPSTASTSLPYHPAPPSRYGSAASPTSYTAPPPSNYTPAAYNPAAYASTAAPQRQPTYSGYNNYSQGYGSPTAVHSSSGFGQSPASSYQSTFQSVQAPSSASAYESSYSQSYSNSYNSYPTNGTGPAAPYPSDDFQTPYPIQSSMPVGPGYTDPSAFYSRPPRSDSAASPVSSPQIQQQHSPGLQRHPTNAPLPSRPMNEHTWDPSAITPTDEDQAQLQDNIIQDIEAELGGRHRPLPINGGQFSDDELQGLRRYNSDLANTNMSHSSAASNVNRAPIPTFDYDDDDDDPEGTAGVLAMQQAELDDRRFSSLPPFIPHDLPAPSNRLPPPPEEQSDDTDYGGMDLGALAGGYAGSLAYGNEVPTQDGSRPLPNPNDYAGASPFTDAGVDYGGTGGLQAPSAHRLSFDEGDEPASLHSKQSGSDSPYKEDYPDIFYHPGLSNRPLPALPGGPESDSSSLLSVHPTTRSHHAHSLSTDSRTLHDGGSDYYGGSTGLNSPFPERSISLSSHSHTPQVQAPVRSRTDAAEERRKMARYQTQQQQLAAQNGLPYDGYESGTPSSMTYDMITLPSGRKRKFVPSKLTSGDLRRCSEPWALSGIASWIREMADGEPDLKQKTVEEALLKLFTAKVPTINVADAELLSGLVSQLMLDAGVLVPEEEWVKFGNGTVSGVLPQLTGSGCYAPKLHEDDSQSGRCYSHQCMRTLKKANLDEMLLEEAKPADWNVHYKIQEAELAEKPKKEIERQHVLHEIVNSEEYFISQLEVLRVLYRDHLRNSQPPIIPPNKIDKFLQIVFGKADAVQLVNKDNLLAQLKYRQQEQGPWITGFSDLFREWIRKAKDVYIDYASQFPYAEYMVRKESDRNLLFRTFLEQVMRHKRSERLGWQHFLKTPITRLQRYSLLLETVEKKTLRDDEEKANLARAIAEIRNVTMECDTKVAEMQKKVEMMELNNMLVLRPGFHSVLNLDHLGRELIKQGDLQRMGSKGVRWVDTHALLFDHYFILAKVVTPKDVRGEKKFDVSKEPIPMPLLFLDTMNDDPISKQKGITAPLARTGGGSDTRLNKVATNGTDRPGLEHVATSSSIASSTTARLTPTMSNDPEGKILYPFKIKHLGHETYILYATSAQSRAEWVEKIIEAKTRHAKALHSQNAEPFRLRVLADSAFVYDAAAAIGRQPGVPIRGTPLDRAVREIEEVYGPGRGPAPVCRAQVNCACGFNAFGKSIIAIGTDYGVFISDATNPRGWMKSVQTTRVTQIAVLEEFSVCLVIADRSLVAYPLDVVAPVSNFPAPAHDNPRRAPQRLAKDVAFFATARMKERMLVFFKRKEGMHNTFKVLEPVFQKATEKRPRIFGGRKGPGGSTDSFRDYDEFYLPTECYSLNLFQSYIAVSTAKGFELLTLDKKQTMSIPDLKQPAIANIAGRIRDQRPLGMFKLNDQEFLLAYEDCAVYVDKHGDVSRTLIMEYSGKQKKATSATMYGQYLLLFNGDYVEVRNAENGRLRQIIAGRDVKCLDFGVRGPTGGNSSNTQSWLSGQTPAGEDSKGTVKISMSHPEQHGVQVVLEMLLNDGHMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9D2</accession>
    <name>A0A1B7Y9D2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157092.1">
        <property type="nucleotide sequence ID" value="XM_018302314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9D2"/>
    <dbReference type="GeneID" id="28866421"/>
    <dbReference type="KEGG" id="chig:CH63R_07339"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07339"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="58"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="443" mass="47716" checksum="3E95B59C8FE355E8" modified="2016-11-02" version="1">MALSNSFLLQDVKIFTGTATIDRGFVHVLNGKIAQVGPGDLPSPLNGTLPVILRPGDTVIPGLIDAHIHAPSGNTSCLEQSLSFGVTTVCDMQNDLETNENLKRLADDPATKSIYADFKFAGSGALVHGGWPLQVLEKELSNVPCSDHLIDQIVSKWTILSRPEEADPFIKKQVEETGVSYIKMFHEVGDSLGMDLPRPPLDIQKAVVAAAHKYGVIATGHALSYAGAMDLLRAGADGLTHIFLDQPPSDDYIQLMLDNKAHCNPTLGLAASQTDEGLGFQDSFLRDPFAQRLLIQKTAGQPLGLAASQKPRASIHNAYANTRALYNAGVPLVLGTDAAGMGFGFPYGLGMHMEMRLMVKEVGMTPFDVLKSATSVTADRFRFNDRGRIEAGKKADLVLVQGDVFESLAANDGRSLRIKSVWRDGISASVFEDVKAETCDNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9G1</accession>
    <name>A0A1B7Y9G1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endochitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157207.1">
        <property type="nucleotide sequence ID" value="XM_018302429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9G1"/>
    <dbReference type="GeneID" id="28866536"/>
    <dbReference type="KEGG" id="chig:CH63R_07454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07454"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601450" evidence="2">
        <location>
            <begin position="20"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="34"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="861" mass="87834" checksum="517FF1AE40862122" modified="2016-11-02" version="1">MLFKKSFLAAAAAISPALAHSSSQPQSKAPSSFGGLSLYWGQYGDPSDRLSSYCDAPGVTSVAVSFVTYSPKNSGGYPGTNFAGHCGGEVFYKNPKTGEDTKLIMNCDYIKQDIKHCQSKGIKVLLAIGGYCPTDGPCSYDISSEDEGHQFAELLHKTFGPYDPTWSGPRPFDISATEHVSVDGFDFDLEFKYPNQKPWIRMVEKLRSVGIYYISAAPQCPTSDTYFQLKELIYNAQFDSLFIQFYNNPGCQASDTPNYDDWENVISQTSKSKDAKLYIGVLASPGAGWNGYVPPSRVKELICKFKSRPHFGGVSIWDATRGAMNQIDGQAFHEAVADALKYGCDPIPPKTSTTSVSTSTPTSSLVSSTATSSTAVSTTSSASSSVSSESVSSSHSASASASSSGSASVSASVSASASASQTGTESVSTSTSASVSASASASASVSDSATHTSTITSLSSSASVSASASASASASVSDSATHTSTITSLSSSASVSASSSATKSAATSDTCDEDDEDFPTTTLSNSHSATPIVTGTVTGSTSSADVTKTASDSATGSATGSVSDKPTGTASVTESAKNTLTSSEELVTSTVYTTKITTVTSCKPEVPCTTGQVVTETVPWYTTVCPATSTSSVVAVPTTTAPPSPPQWVTSTVYATNTYTITSCAPDIPYCPVGQVTTEVVPAYTTVCPYTSTTPAGDGGSKPSGDAQVPSEPSGNVPHPPKSTGEAPKPPVSQGGDKPSGDVPKPTGSQGGNKPSGDAPKPTTTPTGPGGEKCPGGKHCPGGDEDKTTFIYTTLTVPVTVVKHNSTILGTGSSYKPTPTGGFPSYTTAAPLPSKPVQAGAAKIGGLGIAGFAGLAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCX2</accession>
    <name>A0A1B7YCX2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH63R_05633</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion inner membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 20">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158458.1">
        <property type="nucleotide sequence ID" value="XM_018300608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCX2"/>
    <dbReference type="GeneID" id="28864715"/>
    <dbReference type="KEGG" id="chig:CH63R_05633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05633"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000031">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 20" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="177"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR09941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123528" checksum="EC4BFED5F15FFAF2" modified="2016-11-02" version="1">MLRTSIRSVRVLGHRPAAAVVGRQWQVAAARRRHFADDKKPDPSRPAALPTTETITSEKSEVPEVRFVEPSIPKEDVPLTPPTPNTVVPETEAAAPPPLSPADAAPKKKGFFRRLRNLVLTLAILGAVGFGGGVWYSRINDNFHDFFTEFVPFGEQAVLYFEEADFRKRFPNISNKLKGRDTGSQVNIPAQSGASWRVADNGEPASRQSSAVDKKASAKVIAVKEEQNNPVEKPKAATEAPKPTPVAAPEPVKEAKPAAAVKKEDAAGFKAPEVNEPSRFPPIAPIDPLKIEDATEPVVQDLVRMLNDIITVINADKAHGRYSPTISKAKGELSKVGSKIKAIKSSVEEKAASEVQAKVADFDKAANDLIARVESAMVVQETQWRKEFEEEMQKVKASYDERVKLVLEREKQLNEERLNNQLLEQALALKKEFVSEVQNHVEAEREGRLGKLDKLSTAVAELEKLTTGWNEVVDTNLRTQQLHVAVDAVRASLENATHPRPFTRELVALKEIAAEDPVVNAAIASINPSAYQRGLSNAAQLIDRFRIVANEVRKASLLPEEAGVASHASSYLLSKVMFKKQGLADGDDVESILTRTQTLLEEGNLDAAAREMNGLQGWAKTLSRDWLGEVRKVLEVQQALDDAVDALNTLQTPFAVIEARRKAGIRPDEASVKEMRAYLARVGYSIPDLDRLNVIHVAGTKGKGSTCAFTDSILARHRAASPSSVPRKVGLLISPHLIAVRERIRINGAPLSEALFARYFFEVWDRLGESRAEEDAVALGTRPIYSRYLTLVALHAFVREGCDVAILETGIGGEYDATNVVARPVATGITTLGIDHVFALGDTVGKIAWHKAGIMKRGSKAFSVEQVPEAQDVLEARAWEKGVEMETVVVDPRLEGVKIRPDATFQKRNASLAIRLAEAALERVDPDGFRRGDAAEKLPKAFVEGLEQVVWRGRCEVKDEGRVVWHVDGAHTTDSLRVAARWFADETAAKGRRGPRALVFNQQGRTEAIDFLDGVYEGVKRGDGSGAFDTVVFCTNVTYAQTGYKRDFVNHQYDAKAIEAMTVQRQFAERWAKLDPAADVRVVPTIEEALDLVRGVGEGVAEGESVQALVTGSLHLVGGALGILEGADAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD22</accession>
    <name>A0A1B7YD22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial hypoxia responsive domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158540.1">
        <property type="nucleotide sequence ID" value="XM_018300690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD22"/>
    <dbReference type="GeneID" id="28864797"/>
    <dbReference type="KEGG" id="chig:CH63R_05715"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05715"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR10023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25680" checksum="E7E4A64BB4084C82" modified="2016-11-02" version="1">MKILSKEEEAEHYSVVVKAGLIGGTAGLGVGLGGVLLASKRYPAFRQLTLPFRSFLVTSSATFGAIVHADRESIRYGKEKDPMYGYQDATARAIAEARANETTLQRFKEWGRENRYSIVFASWLASMGGALAMVGRDKYLTGSQKLVQARVYAQGLAVAMLVITAAFEMNDAKKGTGRWETVMIIDPDDPEHKHLIEKKIHKEDYEGQDLWKDMVAAEERRIAARKAAEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDZ7</accession>
    <name>A0A1B7YDZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158772.1">
        <property type="nucleotide sequence ID" value="XM_018300922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDZ7"/>
    <dbReference type="GeneID" id="28865029"/>
    <dbReference type="KEGG" id="chig:CH63R_05947"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05947"/>
    <dbReference type="OrthoDB" id="4851153at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132656" checksum="444E33F7288BDD5E" modified="2016-11-02" version="1">MALSDELWRFASEGFYLFVRIFGVLIGLILTILLCAAFEHYATLAIWASVGFLTLGVRHLCEQTTHGLRAQWLALPDRDIKKPRIPEESGIVSRVIPPSPPDQEVCDPITDSEDSSKDENKKEKALVAEQKNMINQIKANHAREMAKIHGRHREFLKQYRQSSEYKDKEIESLKKRVGELDFHLNFLETERFHRPQLEPVPTDLCDHNFKTRGRYPTMSVRLPMLDFSLKDVVRRRKAETNSSFNVTIYRMYDTTVLADGPVSLAQSSPDASKTVEQVIESPIVVPSPVVQPDRPQSSVLSPVSTPPATLPETPLSPAKSPSAAVAITDTPLHRHISRQSLKRSRLKYLVKKLAQLRASLSARPQAQCSETDLASTPAELQTHDLPNLPIESPFPLRPRALPPRVRRLRARQNVHKAFSETSSSPPSLNSASPPPLDPASIPLPASPIPSKLAAPLRPSSPIAAPDSPALSDLPPLPISDLDSEGDGKDDHSDNGGSTVAVKQQQMVKALPAPLPAQPTTVPSVPVSVIASFVIPDNQMDVDDETKQKTKEKEEDEGDEMELDDSDRIRMTLDDLDQCQMDLDDSVQVQRGFEMQDVDMEDEPKQDVDRTDELGEEVDMTDELEEAQAPTSRDIDMSDDLIHPTDAGNAGGNDEMDLDLEHQTKLQVAALLSGNPSPANTSQTSRQQILVQPGGVTPSTPELHPKNTKKIRIKFIQRRQDTPSVESKSSQKLIGDTDEDDFNQDEYFVQPRQASASAEQENSKGSIGNANEYDSDLAEPEKAQVSIELVQRRRTIPTVDSERLRKSVTANEDKPDQKAPSTPQPEPEKTETKVKIVERQQASPTEEPEILQTTSNGTPSHFQAGNVTPSTPVPKVKQPEGKIIIFRRKPANPMMPRKKTSKSPCVKGLKQQNAKSMLQVGTSPSLSVQAPPNLTSGSPSEGRIRLFQMTALQNTLSLTTAQSLQQPQLFPDRPARKHKFEEVDAVDENWDGDIDLDGPPRKIAPLPARAQKGPSAVDEETRRRLALEAKRRWVLVQEQTAISRLDPIVEHPRSRPPPQVASEEVSSRDDRLLLFESPELRQELLHKLQVLWPILPKDEVDRIRLNKLRSWALAEWRKLLNPAGKDKLPANTYISMDSFEREVGKWMQRVVNMMVELNVVREVNPVLWNWRELVVQQGPRPEPEVKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YES7</accession>
    <name>A0A1B7YES7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159033.1">
        <property type="nucleotide sequence ID" value="XM_018301183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YES7"/>
    <dbReference type="GeneID" id="28865290"/>
    <dbReference type="KEGG" id="chig:CH63R_06208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06208"/>
    <dbReference type="OrthoDB" id="4624666at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="102" mass="11645" checksum="193F3BF5AD5CEF9D" modified="2016-11-02" version="1">MAPTPSERAQAKFFAVLEDPRRYDSTSPLPRTMTPYRNEADTCETDFKNRVMITRTPSGGSELTNVVSHPPPRRASSSSQGSVDDHHRIRNRIKNWMYRPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFR0</accession>
    <name>A0A1B7YFR0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_06514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159339.1">
        <property type="nucleotide sequence ID" value="XM_018301489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFR0"/>
    <dbReference type="GeneID" id="28865596"/>
    <dbReference type="KEGG" id="chig:CH63R_06514"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06514"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR10822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="724" mass="80559" checksum="7E8D0D760670F53E" modified="2016-11-02" version="1">MATISPSPPQTIECGNSRPVACANCRQRRSYCSKEKPTCSRCRDSGLRCTYEETRKITITEAYLRDLEAKAKAYDESVAKQSQAAANTKAHRNATEENGEEFEDGHPLLEPFNQLSVHNPSTSFKGPGNSDNFLRSVRKLSGFYGDDGSLDANTNFYEPSALPSRREKARTQVRLPPIDIARRLFAAQYTYIGTIFAFTDPKAKFDQSLIEAYRGPPDPSDREACLSYAKVLIILAFGQLYSVNQWVDFRGPPGFDYFTHALNLLPDTHEEGSILCVETLALIGYFMQNMNRRDAAFLYTGMALRMAISLGLHHEIGYSPVQHPLQGQEASLTTLDDATREHRRRVWWSVYSLDRILSVKSGNPITIQEEDIGVDLPSRLPKEAEYCPAVVLRHYTELSRILGEIHNTIYRKTSKTAPKSGKRLMASVQSIVLSLSKWNRELPDELRFDPARLSISRESVSTFAHYYQCINMTARPLLFHVVQKRLQRIRSSDDPGEKERDWKEGLSQTTVRVIDMCIGAAQDSINIMTVAAQRDLVATYGYMDGEHVFSASIVLVMVCVAFPTDASNILAMNAGLDLLKGMGERGNSYMGARYELLANLRPTAMSGNNAQPLPLPPFPTSFSPTDSMMPTGPGSAQVSTIPTTMGDGHGNLTTMQGVLSQRVTFPVVDNSSLGEPFYDESVSTVMDFGLWEEGFADPAMDASFDFSQWTQTAGMAQADDRMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG20</accession>
    <name>A0A1B7YG20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159472.1">
        <property type="nucleotide sequence ID" value="XM_018301622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG20"/>
    <dbReference type="GeneID" id="28865729"/>
    <dbReference type="KEGG" id="chig:CH63R_06647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06647"/>
    <dbReference type="OrthoDB" id="4153862at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="198" mass="21780" checksum="14EF65886F080DB0" modified="2016-11-02" version="1">MMYIRSPSSSVICQSSFLIPNSITQSFLLLSRRPDILFHPLFLASQSFELSKQSLDESNTPILLRHSKYQYTQAILLQPTNDKMKFSPQSALLVLALALHASAAAVEDPAMAAVRRDTLLMERQGANDNRPVPNGACCVANTSLKQDVCNVNGQTGRCVPDSVNNCGAKLTCIEDSRLDCDPNTLERGRPLCRRRQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHC2</accession>
    <name>A0A1B7YHC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159899.1">
        <property type="nucleotide sequence ID" value="XM_018298653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHC2"/>
    <dbReference type="GeneID" id="28862760"/>
    <dbReference type="KEGG" id="chig:CH63R_03678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03678"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="174" mass="19267" checksum="546A313BB73AC9F5" modified="2016-11-02" version="1">MGVFGGRDELTLPLRFRRETRVSALDYGDVEEHDGHEDGHTSVPHRGPRDGQGDMFEDDADEEHNVESRADTEDRSTNHAGPGGTSEYMGHGFTGRLQNPAGDLAHSPRQGAGPLIILVLLTAAFFTQAPVALSWLPRLVFCSFSSSFFRIKFPSRTRKLLAKRLIDTDVSEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHW4</accession>
    <name>A0A1B7YHW4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vault protein inter-alpha-trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159971.1">
        <property type="nucleotide sequence ID" value="XM_018298725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHW4"/>
    <dbReference type="GeneID" id="28862832"/>
    <dbReference type="KEGG" id="chig:CH63R_03750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03750"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="50"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="332"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1091" mass="116043" checksum="0957FB3DB46CC69D" modified="2016-11-02" version="1">MVFGFGHAPCGVFGQSISHHPNSNSNSNNNNNYRRNTHVCGLYYLDTTQNFPSRGSHSYPRRYLPMLSQSVHARIVASASRSTLTQTFVNPSADAPIPELRYTFPLYDGVSVVAFTCTVNKDRVIRGVVQETNTARRTYDNAVAKGQTAGILEQLPDASDVFTSSVANVPPGAEVAVEIEYLGELKHDAGVDGIRLTIPTSIAPRYGAYPGTLLDKPANVSAAQDGITIVVDAEVPAGSVIKSIQSPSHPIAVSVGSTSTTKADAAPSLQLASATLSLGTARLDRDFIVQVIATNTSNPVAVLETHPTIPHQQALMATLVPRFKMPATTKPEVVFICDRSGSMQGARMTDLRDALRVFLKSLPVGAMFNICSFGSEHSFLFDKSVTYDQNTLEAAMRHVDTFAANFGGTEIRQPIEQTFRRRHVDLDLEVFLLTDGEVWGEQGLFGLVGDHVRESKGAIRLFTLGVGRDVSHSLIEGLARAGNGFSQCVSHKEKMTGKVVRMLKGALTPHVTDYTLELKYADAGSETEPEDDFDIVSTDDLLKPLDRGVVLPPVEPKKPISLFDAAASDGEDAVMHDVADDGTGTDRFSHIPAVKPPKVLQAPFQISPFFPHSRNSVYLLLSPDRELRDKTPESLVLRGTSTQGPLELRIPIAVLPDKGETIHQLAARKAVQELEEGRGWIYHAKSGKDGRLLSEAHPGRFPGMVEREAVRLGVQFQVGGKWCSFVAVDDQDNEVSVEDRELAADRVRGHTEKRSSSKSRSCSKVSMASSIYFDSPPADHSAPIPLCRKGTPPKKMETRTPPPLSWTPVMFGSSALQSNSTSAFGLMSYTPPSGGGLFSGPSTGGGLLGGPSTPSTGGGLFSGPSTGGGLFGGPSTPSTGGGLFSSPSTGRGLFSGPSTGGGLFSGPSTGGGVSASAAVPDASALSGAEHFRSFAVSDPIRPIAMQQNTAAADDGVECEESSSPKPAPPPPPAPAPAPAAASFQPATASTIDRFEAIVSAQHSSGFWTYSDGLMSLLGVSDRDLRSAVVDAVGNRFSPVLMSTVAVVAFLRKNLAHERDSWEMMEEKAMAWLNAELGDKTGDVMDAVKRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI27</accession>
    <name>A0A1B7YI27_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160250.1">
        <property type="nucleotide sequence ID" value="XM_018299004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI27"/>
    <dbReference type="GeneID" id="28863111"/>
    <dbReference type="KEGG" id="chig:CH63R_04029"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04029"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="56756" checksum="D0E6E5719AF15DCD" modified="2016-11-02" version="1">MAPSKKTRVAKKQQTSATGSRTKANLPKGKANAPKIRTNVPKGKARDLAKNSKSAAPPQPQDTIVVGGQKRHVIAVEDDSSDEGTIRPPKRRKGGKGPDPHDYHAVREAPPRPLSGQFARKSTAHYTWGASFQSPPLSRFKAQEKQSEANAVVPLVNEKGKKMGRSKNPSQLRPSRGSGGLLSMSARLKSLNGKNHFFFMNLPLEIRQKIYKEILVAKNPIRVRQGWSAVYPRNRPMVETDILRVCRQVRNEAVNVLYGENTFLYLLREAAMLPATNSLGENEIVVQHPLLAEEHLSEYEGNSEDEYDDADLLPMARSMRDSEIEIDIRRYGHKFRKLMIVAEPNRTEKGYLLSMANAINVFRNLKPIRPRVHTLTIEITPIRDIHTGEISFLDFFEKTSEVVRALRGLPCQFIEILINTGGGNQERIRLNMKYAANIRRAKRGQEDAWENDRVMQSYRSAQAGDAQQSLDSLSVMIQEVWEGPNGRFVGGLNSDESDEHEDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJH5</accession>
    <name>A0A1B7YJH5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160746.1">
        <property type="nucleotide sequence ID" value="XM_018299500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJH5"/>
    <dbReference type="GeneID" id="28863607"/>
    <dbReference type="KEGG" id="chig:CH63R_04525"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04525"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="652" mass="69706" checksum="3595589F7CE2142B" modified="2016-11-02" version="1">MANSLNPVGSASHMSSSALLPAHHDAEARPRNRRLISTVDDSSSTGGPMESLSASFSALRTPSNRAPSPMPSSQLSRDTSTKPAARTTSASNRRNNTTPNTASFLDTTWSQGWASIQGLASSILSGGSVHEAGYESDHREGRRTGFNPLKRDYSTPPRKTPKDWGPAPPSSSRPGHQDIAAGSLAERNAALKAARTASVLESHEGVNGGLDVAGKYKRRNSDEVIRDTPQEEEVQDQLVYIHHVQPTDTYAGIVLKYRCREDAFRKANGLWSRDIQVRKWLAIPVDACEIKGRPCEPPSNEGQAVDLLAPTPEPRSAHGRGGLTSAQSQQVDFFSLPTTNDSTSELPKSEEQEEQPWTHVRWVTLDSVAKPVEIARVSKKTTGYFPPRRKKSLRSTSTLSTPRHSLDTAAIVAGFTESPEQVGRSSSRRQSNLSSRPNLPSTPGRSTPASSRSRMNSDAGDTRPAWMRRPGGVGSLGRSVRAPGPERDYLNSWAKKHLPGIAIDESLPSISVMGSETANFGFRPGSSGGIVESPFDEGQDLLATSRQSSGLDRAAATVETWLRGAFAKAPGTPTLGTRSRHPDDLDLIELTDTNSDDGRLSLPVGGGLTSSGFLEAAPMSDVGSTGRSDGDGSVRGRTLGHTAATAKGKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJU7</accession>
    <name>A0A1B7YJU7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UMTA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160817.1">
        <property type="nucleotide sequence ID" value="XM_018299571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJU7"/>
    <dbReference type="GeneID" id="28863678"/>
    <dbReference type="KEGG" id="chig:CH63R_04596"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04596"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="367" mass="41737" checksum="BE48B550D569D368" modified="2016-11-02" version="1">MASDPQTVPLDNTFLETVTYQGREYQRYAVDNGAYFAPMDEVRNTSGPVTAFLLRLTFPTGLQDEVERLQIMHVVLSVVFENQLLFPPITRPRRILECGFGSGDWAIEVAQRHPSCEVVAIDICPHIWPDETETPTNLNLQVDDLNGRFTFPSNHFDLVHSQMMAGGIHSNRWRDYIGDMFRVTRPGGWCQMVEIYFNAQSDNGTLTQILLPDHALRRWSRRYLDSMQPYKDPRAPLHLQSWMQSAGFDSVETQMIPLPTCGWSNGKEIAEAEYLLLGLIGDSDPRQHHIGVVNRENVRRMLSSLAMYPMTEFRGMTSQEFQVLVAQARSEADNPAFRDGNLVDEAYQDARRRGCLFVGAFGTFGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJZ7</accession>
    <name>A0A1B7YJZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase subdomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160916.1">
        <property type="nucleotide sequence ID" value="XM_018299670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJZ7"/>
    <dbReference type="GeneID" id="28863777"/>
    <dbReference type="KEGG" id="chig:CH63R_04695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04695"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="581" mass="66018" checksum="92BE665C1060C84C" modified="2016-11-02" version="1">MASRPWDTLPAETLVSIAAHLEGVHLPDLSSFALTSKSCYAAAACHLFRDVHIRIKHPRKLHRDVAKWLAVLRHANAARHVRRLVMTFEDKTLHHSDLYSPDRLKLTPESADSLSYAKRMLPENRRLRDAFVNPEAWAPMVQLLKVLAGLTDMVIEHESSFSPYLLEALGTQHTKCLLELRCFDLHCTEGTSFNPYDVALLLSPQLHGISIKEYFQSFTGHTNESVVSRLVKGLSPSLKKVELEPVFGARYHRRCNPEFESQLQTLISQATSDNLKYWRNAAKATVAPKIGSVPFLSLQRTSPERIRAWVETTDFALLRHLRLNTGSRELRWLAKHAEFRQLDSLELHNRGYIGAPSDEENFDEIENAAVDFLAGMPALTSLSLEGQLTSPMLRTAVSRFGGTLRKLMLRPTANGLLPEEDIKLGPEHIDLLPLASPLLEDLTITVAVPTFLSQSTELAGICESLARVPHLRSLHLTLRSTTEEDPLMVSKRRRPRIDRDGKFQSPDILREELTDEVVKWAWEAICERGSRLELLRMDTLYRWSGARKSEKVHQVRRIGAMGEGVVAETLYRRNRVLRWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKF4</accession>
    <name>A0A1B7YKF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160921.1">
        <property type="nucleotide sequence ID" value="XM_018299675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKF4"/>
    <dbReference type="GeneID" id="28863782"/>
    <dbReference type="KEGG" id="chig:CH63R_04700"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04700"/>
    <dbReference type="OrthoDB" id="4810499at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="160" mass="18224" checksum="80BC3DB7FD840FF7" modified="2016-11-02" version="1">MPLAGLMFGSDASARLEDMLICRGITVWFHWLPVIYVGGLDSESPFIDVNSCEMLKDRDFRNAFSDAYTRKFTTNGQMFTIWAKDPGEVPNWHLLNFVSCTSTTTTKTGWLRWPQQRQGEELSRTKRPTLLLRPGLVGLRVGRARPADDYRPSPQSEVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLC3</accession>
    <name>A0A1B7YLC3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UMTA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161279.1">
        <property type="nucleotide sequence ID" value="XM_018300033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLC3"/>
    <dbReference type="GeneID" id="28864140"/>
    <dbReference type="KEGG" id="chig:CH63R_05058"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05058"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="42335" checksum="4719DE45ECAA5067" modified="2016-11-02" version="1">MSEATDQQMSLAPATVVSSVSATPGSARPNTSSIIPELETDGEAQELVLEPDEGETFDDVRLIDDRISSYTASLTSSVVDYPVEYGRRYHAFRAGWFSLYRSERRARKRPAGHDTCPDRKGNWEQAFFLAPIETENVHRILDIGTGTGIWAMEMGDFFHHAEVIGNDLSPTQPEWVPPNVRFEIDDVESSWIEGKKYDFIFCRYMVGAIGDWETLVKRVFNNLNPGGWVELQDMRIQLYSDDETLEKNGKSTMEWIGPFVKALQSIGREPNPGPLLEGWVREHGGFDHIAHQKFRMPLGPWRKEQYYKDLGLLNLAQILKGLEGGSMRLFCGVLGWTTEEVLALLAGVRQELKSNRLHPMYDLQVLCFFPNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMZ1</accession>
    <name>A0A1B7YMZ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161928.1">
        <property type="nucleotide sequence ID" value="XM_018297112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMZ1"/>
    <dbReference type="GeneID" id="28861219"/>
    <dbReference type="KEGG" id="chig:CH63R_02137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02137"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="433" mass="45985" checksum="762BE4AD4A40008D" modified="2016-11-02" version="1">MPPAEDDDDFVFVSHADAHPAAGPSSPEHLDEISAVVADLADSLWPVNKTIHDNPELGYHEFIAHNALTSFMRTQPGWRVTPSAYGMATAWVAVWDSGRKGPVVSFNAEMDCLPGIGHACGHNLIATASLAGALATATLLSRHRLPGKVVLYGTPAEEGGGGKIRLLRAGAYADHAVDLNLISHPGIVADTALMRTSAYASLRAEFFGVEAHAAANPWLGVNALDALVISYNAISVLRQQTMPGDVVQGNITHGGARPNIIHAYAAGDFVVRADSSARLAELRRKVDRCFAAGAEATGAKLRITPTGSYLDHVPNRVLGRSYARYFNALTDPGESGIPVDQDVDETRGRTMASTDQGDVSYAMPSLSVGFAIPPGDKGQGPHNPEFAEAAGTRVAFERSLRVGKGLAGVAFDVYTKEGMLDEVKRAWRKDMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNS8</accession>
    <name>A0A1B7YNS8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162186.1">
        <property type="nucleotide sequence ID" value="XM_018297370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNS8"/>
    <dbReference type="GeneID" id="28861477"/>
    <dbReference type="KEGG" id="chig:CH63R_02395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02395"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="372" mass="41458" checksum="B0F76401E1D0BA67" modified="2016-11-02" version="1">MPPEDMAQPDFAYRPSAMSNGPWNSTRRKAQCTMMHSHPLEGLTATTIAHQGKSQTSSFLPFSSQRNKRVTPSLQSVSTYSPGTSNYNLPIGTNPHVAAAAAAAAAAAPAYGSRPASGTYGTSGAAGYGSYKSTNSQAWDHQERYSPTDSVDDIIASPNLSDYSLENGAGATPPSKGKVNGKGRPQRRPSNRDEFDGPHQFLARPPPEYIAMQERELPHLPTNLHVQEQDMVLTQVNDRLSQCAYDFVAKYQFPIPLTQDMRPVERPQDREWTEWVYLLKRLATKRRIPARVLYNGQIKQFVTILENSLEMRHAAKHQSRPLKDDRNILQLISAGIQVAKILKDASAMEYLDRLYVSTEKQIQDRAVARFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQC9</accession>
    <name>A0A1B7YQC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162615.1">
        <property type="nucleotide sequence ID" value="XM_018297799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQC9"/>
    <dbReference type="GeneID" id="28861906"/>
    <dbReference type="KEGG" id="chig:CH63R_02824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02824"/>
    <dbReference type="OrthoDB" id="4867214at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="366" mass="42595" checksum="DE205F19B76C3813" modified="2016-11-02" version="1">MPQTSFYIQELRGLQSRFNTTIPISSPPKIPNSSTAFSLNRHKMECYHPSPTLPVVPKCRLLPLELLKQKAYAIGRHVEIYVKCDRCDRSIIAPVSCNWVLRMSEDKIRFPGPVTTMIRVSPQLCPGYNDGSCIAMRTPEYIQTWVKLKSVPGVLKTDREWLELRHPPAEGYSAPPEWQDRLRRATKLMPSLTPPYTRYLCWRFAWHLFWHHKGMRHKDAPLERMWGNVAADVLLWHFQLLGDADLEALYCTSVRSLVGLLVCQWDCGITILEMFYAVRRDLDKPCFNPLKSAVQRADTAMRKYITAHVARVGHKEQEYRRWMVSDAFLAIEDKLREHMGEEEHLFLTERWSPPLPLLNEDFGLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR01</accession>
    <name>A0A1B7YR01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162978.1">
        <property type="nucleotide sequence ID" value="XM_018298162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR01"/>
    <dbReference type="GeneID" id="28862269"/>
    <dbReference type="KEGG" id="chig:CH63R_03187"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03187"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601844" evidence="3">
        <location>
            <begin position="23"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="228" mass="24017" checksum="DA63F7591676CDB4" modified="2016-11-02" version="1">MHHHFSLSALAALVPLAAFAQGQQPCSTVNIILARGSLEAQGVGLLGNIAKNASTQIPGSIVTPLEYPAQLDPYPPSVAAGVTNMTALLNQQAQQCPGTKLVLMGYSQGAQVSLDTLCGTSDGPNFNTTVAQAPMVGSKNNVVAAVVLFGDPTFVAAQPFVRGTSKKNGIFPRQDFSQCQGLTSRFASFCDESDLFCASGQNLTVHLGYFQNQQYIAMASSFIVENTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YS44</accession>
    <name>A0A1B7YS44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sterol desaturase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_00023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163360.1">
        <property type="nucleotide sequence ID" value="XM_018294998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YS44"/>
    <dbReference type="GeneID" id="28859105"/>
    <dbReference type="KEGG" id="chig:CH63R_00023"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00023"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="341" mass="37248" checksum="F474DB2DBC092D27" modified="2016-11-02" version="1">MDILLSLPIVSYFLAPSVTSWTTSLNLLFFYMTWTTLVLSHGPLKVQLLGTLAIRLALWLLPSLAFLLFDTLIPSIAESIKTAGASALPPAHGPTLLRTLLLALFNLALSAGVEGGVSSAYASLFHEPLFRASTALPLPFQLMKHIAFLIAAREVLTYYIHTRVLHARAGGRLSRLTPARIGRLHDSYAHARDAPPFSLMLFADHPLPFLLHRIVPGFLPALVLRPHLLTYFLFVGLCTVEETMAMSGYSVIPGIVMGGITRRTAIHYAGGGRGNYGAWGVLDWAHGTSRGQDVVDDMRAEAEKHRVKERSEKAASSGAGFVQNGIQEFRKDRGRKAKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSM0</accession>
    <name>A0A1B7YSM0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LEM3/CDC50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_00206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163543.1">
        <property type="nucleotide sequence ID" value="XM_018295181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSM0"/>
    <dbReference type="GeneID" id="28859288"/>
    <dbReference type="KEGG" id="chig:CH63R_00206"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00206"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="30451" checksum="18B3A254D77E7677" modified="2016-11-02" version="1">MAIREVRFDYTRCHEIDLYDEPELMPSENTYRHFKASSTGHPLTQWKRSNQSLTFDGITKNYTMCTIDFFLPDDLQPPVLFYYHLTEFHQNHRKYVTSLDGSQLKGKSVSRGSVKDSCFPVTSSRRDGGEEKVIYPCGAIANSIFNDTFADPQRLLGPDADQPVPYAMSRTGIASDLDKELYRPTTYPVPPGPGDNDSAVIVPPPNWAERFPRGYHSGNMFNPAEDEAFMVWMRTAASPSFAKLAMRNSDEVMVRGMYRLQVFSRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT40</accession>
    <name>A0A1B7YT40_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163732.1">
        <property type="nucleotide sequence ID" value="XM_018295370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT40"/>
    <dbReference type="GeneID" id="28859477"/>
    <dbReference type="KEGG" id="chig:CH63R_00395"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00395"/>
    <dbReference type="OrthoDB" id="5286874at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="547" mass="62170" checksum="281255B440E2FE33" modified="2016-11-02" version="1">MSQYETTTWREEAAPPRRRGPSLFSSRTSAQNLRSQYTREAQTAHLVQLIEEFRKADPIYDPVPPTPPPRAPGRQRSQRAVHTQPVVRFASPLDPMSARRRRAKTPLSAPVVYEVVTQTPQTPQTLQNLDFAVATVTPGEQEMRLRQPTPEEPVTVLVNNDDEGTDLQSFDLDGFPMPPDFGAREEYSGPGYDGDEWVDLEETTGKVYAFDPARLGADSSRTDDGFDLETPFSDDSTMRGEELPPSRALHVYRSRYTGDGVLGGTHSAALDVVYDAKRKRQSLFRWLHVQQDMMNFDEFTSEISKALSEREQNDIRKLLSDVRKNYAKTVRTSRATTVKHMDPSYLQLPLQQGDQEKGAQAGKRTATWLCIPYFSLEEYSGIQATGNPGAFPPLTLLQLAFSRNSQKRDMLQATRQIGNGEKGWCFHIRQLWCIVLDNSLLITCGSMYEEALRGDNIAVTSEPGREPTPNSDTEGRILIRYGESVLWSFPLQECQTWFAFIAHFSDFWPKAVRFHFNGRLLNEARWWKVLQFAGTSRRSVVINMETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU00</accession>
    <name>A0A1B7YU00_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_00604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163941.1">
        <property type="nucleotide sequence ID" value="XM_018295579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU00"/>
    <dbReference type="GeneID" id="28859686"/>
    <dbReference type="KEGG" id="chig:CH63R_00604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00604"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05586">
        <property type="entry name" value="STKc_Sck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="289"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="496"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="758"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="896" mass="99026" checksum="1B1CEBE32624AEF8" modified="2016-11-02" version="1">MNLTVNHHSRTPAAAADEDGADQIGFDTPRSGVATPQPDLHDKRLPGIMSYFGQVRTDSPHNSVSAPVASDRNHRGQSLPGPETKQVETDGNASQVSSTDAVPGGDPEPKSLSLPHPPRERPSSPNTSPMALVQTHQYPTPPISRRSSVGLLKRSLSLRYGETRSAASSSARPLLQRGVTDYPKKCHSLTLMSQPSSIVTTSAVHAHHISNPSLPKPITPKTPTHPHVGSAQKATSLHSSSSVDQLKKLTQVAAFKSGPPTPTRALSAAQPSQSEERSSSKRSSNETVPPSGTQTPRSGTTGAQVPAARGKLTIKIVEAKGLRRAKDPYVVAVFQRSELISGGPRSVEEEEDVNLPPPSFGGIPIQRQGSDSGRPAMSIPMRSRQSSNTSISDYNTFRNRSRRSFTSPKWDAEAEFDVVDSNMLVNISVYDHSANGEEFLGHVDLQANRDSNNPVRGWFSLKGHADTVAENAPTGEIYVEAVFQRTERKHFGPEDFQILKLIGKGTFGQVYQVRKKDTERIYAMKVLSKKVIVQKKEVAHTVGERNILVRTAMSDSPFIVGLKFSFQTPSDLYLVTDYMSGGELFWHLQKEGRFDERRAKFYIAELILAIQHLHNNDIVYRDLKPENILLDANGHIALCDFGLSKANLTKNDTTNTFCGTTEYLAPEVLLDESGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDTLSQEGRNFVKGLLNRNPKHRLGATDDAEELKRHPFFADIDWDLLAKKLITPPFKPKLTSATDVSYFDPEFTNALDNNGSLNERAAALSKGFATSTPLSPSVQANFQGFTFVDESALDDHMRDKSRYDDEEMRDSHHQDDDWDDLEDVNHKSNRMSGIVRTTTNDEQMIGGGHFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUD6</accession>
    <name>A0A1B7YUD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 14C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_00845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164182.1">
        <property type="nucleotide sequence ID" value="XM_018295820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUD6"/>
    <dbReference type="GeneID" id="28859927"/>
    <dbReference type="KEGG" id="chig:CH63R_00845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00845"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="109" mass="11286" checksum="B02F66B40F3D56A0" modified="2016-11-02" version="1">MKLTSSDLSIPSFVLGALTAGGGIAGYARTGSLPSIIAGVSVGLLYGLGGYRIQNRESFGVELSLLASAVLGGSSIPRAIRLRKPVPILLSVLSVFGLFTFGSEFRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVP1</accession>
    <name>A0A1B7YVP1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_01301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164638.1">
        <property type="nucleotide sequence ID" value="XM_018296276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVP1"/>
    <dbReference type="GeneID" id="28860383"/>
    <dbReference type="KEGG" id="chig:CH63R_01301"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01301"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601944" description="chitinase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="85"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="381"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="509" mass="54356" checksum="44475CB7AF10CB88" modified="2016-11-02" version="1">MLFRSLCLVAVTALAVEAVSKDASCDDDVLTPSAPLASGPLSKTRLPGSQLSGYPPSGPYSSGSSPSRTLPSTSNHSLPARVSAPRYVMYFDQYHTAGVPDKSITAGVTHVITAFANSSLFASEPTGEYKPFKPINEIRALFDNGTKVCMAIGGWADTDGFSRGASTNANRNKFARNVVDSAVKLGYDCIAKTITNAIKQQDIDWEYPAGNGADYKQIPNANKTQEIDTFPLLLSAIKTQLKHHKMELSVTAPGLKRDMIAFTQKQTPKINAVVDHFTVMTYDLMNRRDNVTAHHTDVKGSLEAIDTYIALGVEPGKINLGFALYAKWFTTAAGYTCSEGLGCPTELLEAADGTDTGKSGAVTFEAANFLAAPTNLTTSPDASCGTGTFYKCPTGNCCSQYGFCGTTEAHCSSGCQSDYGICNGTSTAASFKTAMANGKTDEVSGGQWYWDPAGPFFWTWDTPALVSRKFNDIVKARGIGGVAAWSLGEDSHDFSLIKIIQAGVRAWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVR8</accession>
    <name>A0A1B7YVR8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164662.1">
        <property type="nucleotide sequence ID" value="XM_018296300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVR8"/>
    <dbReference type="GeneID" id="28860407"/>
    <dbReference type="KEGG" id="chig:CH63R_01325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01325"/>
    <dbReference type="OrthoDB" id="4789721at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601945" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="91" mass="10221" checksum="6D74C3827BE688DC" modified="2016-11-02" version="1">MRFTALTSLLVVALMAATGNAGKPAQVPHGCWDKCTKECLAWIVPFVFTFPKFIDCRKECVIKMYHAECREMLKNLNLGGDKKPEKKIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVV7</accession>
    <name>A0A1B7YVV7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalyzes late reaction in the cephamycin biosynthetic pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164609.1">
        <property type="nucleotide sequence ID" value="XM_018296247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVV7"/>
    <dbReference type="GeneID" id="28860354"/>
    <dbReference type="KEGG" id="chig:CH63R_01272"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01272"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="305" mass="35224" checksum="1B72B655EBE2C30C" modified="2016-11-02" version="1">MFLWSQPSLGGKTMLHNDNGESNSYRLMFLASPEPPKWAPKVDSPVIVTDVTGDEEKYRLLEHGFQFAKHKTRYEAVLPELKNRDGCREALDETTKAHYDEMHELLEEILSQQEGLPKPSLIRVLMHTNRVSQVGQKGTLGPIYNVHVDQSASAAVPLAHRWLGDEAEELLAKPRFQIINMWRPCKPITRDPFAVTDANTVAESDYIKVPFIYPDRTSELLEVCPAEHPEKPHRWYFKDNQQPDDVLFFIQADTTKRPGVVRRCPHAAFKDPRVDESKQDPRVSIEIRAMVFYDHDDYEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW93</accession>
    <name>A0A1B7YW93_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164842.1">
        <property type="nucleotide sequence ID" value="XM_018296480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW93"/>
    <dbReference type="GeneID" id="28860587"/>
    <dbReference type="KEGG" id="chig:CH63R_01505"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01505"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="103" mass="11541" checksum="115ADA5EB82D191B" modified="2016-11-02" version="1">MAPKTPATAEPGDDVKLLKLLRVAKTGSAAPLQNQYQAVVSLSLSTQHDVEALVYRSYQGHRHLSPSAYRPLVTGHNAAVHDQRRVMWMDEWMDGWKNDDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWJ1</accession>
    <name>A0A1B7YWJ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mixed-linked glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164923.1">
        <property type="nucleotide sequence ID" value="XM_018296561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWJ1"/>
    <dbReference type="GeneID" id="28860668"/>
    <dbReference type="KEGG" id="chig:CH63R_01586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01586"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601981" evidence="1">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="201" mass="20686" checksum="63BE59236848147F" modified="2016-11-02" version="1">MRTSSSTHVVALSCAALARLAGGITIVPGSTTGPFVFSNLTTSSATALPAPSSTTTPSTLPSGINLPDPNIYVLRGCLGSPSGYPSFNLVGVDPEMTVQRCVSLAQGRRYAGVYNEEVPKLHICCPRSSYVRDGPWSGPSNQEHGFAAEAPAAAGSGLPENKPTQSRPGTVVVAGSRGWKDDIAVTHSAAVVVALAVHFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVG2</accession>
    <name>H1UVG2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_00728</name>
        <name evidence="15" type="ORF">CH63R_10903</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR06783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018305877.1"/>
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    <dbReference type="STRING" id="759273.H1UVG2"/>
    <dbReference type="GeneID" id="28869984"/>
    <dbReference type="KEGG" id="chig:CH63R_10903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10903"/>
    <dbReference type="eggNOG" id="KOG0741">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_008037_2_0_1"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_3"/>
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        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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        <property type="entry name" value="ATPase_AAA_CS"/>
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        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="563"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="RuleBase" id="RU367045"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR06783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="765" mass="84544" checksum="3E65221F8CF5B155" modified="2012-03-21" version="1">MSFPEKPLPRQQPHSPRQPGVRLRVEKIRDKALQTQLIYANVAGVSYRDFAPSRDGTDINILIRARDPVRGTVRENVVRARPTPELPEGTISLSDPQRQWLKIGMTDTFEGEVYDASRQGATHLEAMDLELSWASMKRDPNYEFTHEYLAKVFERFFQMHFFAPGQRTLLDIEGLKVFATVKTITFQGGRGPEAVVTTSDPSARGFYSTATLLSFFKAADSELKLQVGEHQGNANPIISPDFKFEDMGIGGLHDEFSTIFRRAFASRVFPPQLVAKLGIQHVKGILLFGPPGTGKTLIARQIGKMLNAREPKIINGPEVLNKFVGQSEENIRKMFADAEKEYKEKGDQSGLHIIIFDELDAVCKQRGSGAGGGTGVGDSVVNQLLTKLDGVDQLNNILLIGMTNRKDMIDEALLRPGRLEVQLEISLPNEEGRKEIFMIHTAKMRDNNIMDPKVDVASLAARTKNYSGAEISGVVKAATSFAFNRHTEVGNSAKMKSDVSAMKITMDDFENALIEVKPAYGVSEDEISNALGMGILQFNDNIPAIIRTMMGYIDTVKESDVLTRIPVLLHGPPESGKTALAAHTASLSDFPFVKLVSPQHLTAFRDEFGKKDYLTKVFTDAYKSERSIVILDNFEQLIEWNPIGPRFSNTGRRILIMVTTSERFILSNLGVLKHFRRQIPVPAVSDVRELASVLDQTGMFGANDVQAVIGSIQNDTRSEKIGLGIKTILESIEESKVEASSQGTDMLESVANRIVTAISSNALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVS0</accession>
    <name>H1UVS0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04529</name>
        <name evidence="4" type="ORF">CH63R_05179</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000312">
        <property type="protein sequence ID" value="CCF32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161400.1">
        <property type="nucleotide sequence ID" value="XM_018300154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVS0"/>
    <dbReference type="STRING" id="759273.H1UVS0"/>
    <dbReference type="GeneID" id="28864261"/>
    <dbReference type="KEGG" id="chig:CH63R_05179"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05179"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="338" mass="36488" checksum="7DAEF130EDE63F6F" modified="2012-03-21" version="1">MSRYASAHVDPQGPGDARPTALQIVEDEGLIGKLAGKVVLVTGANAGIGAETARAIHATGATLFLTARDSTKAQQAVDGVRNGPGPKSGAPIHAIELRLDSLASVRSAAKAFLSKSDKLNLLILNAGVMATPEGRTEDGFETQFGTNHLGHFLLFQLLKPALLAATSPDSEFQSRVISLSSLAHQLGKVRLDDFNFEKEAYQPWSAYGQSKTANLYFASELERRYGSKGLHALSLHPGVIATGLFQHLPQDQLELFSKDESMQKRMKSIPQGAATTVYAALSKEWEGRGGRYLADLVEQGPAPESEHGRSGYAPWAYDEDAEKELWEKSNKLVGFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWN4</accession>
    <name>H1UWN4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04785</name>
        <name evidence="9" type="ORF">CH63R_07041</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000409">
        <property type="protein sequence ID" value="CCF32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156794.1">
        <property type="nucleotide sequence ID" value="XM_018302016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWN4"/>
    <dbReference type="GeneID" id="28866123"/>
    <dbReference type="KEGG" id="chig:CH63R_07041"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07041"/>
    <dbReference type="eggNOG" id="ENOG502SP40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144932_1_0_1"/>
    <dbReference type="OrthoDB" id="3928926at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12798">
        <property type="entry name" value="Alt_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51895">
        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497516" description="AA1-like domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="15696" checksum="637BD50F6B67C03E" modified="2012-03-21" version="1">MKFTLATVAALFGASAIAAPAPQEDAPRPSENIDIADLSVRKQQNGTVTNVSFLLSGDDATDLACQGSTGVPSDVITCGDSKYRFTIRQGTETEFALRIYHELGLAVGYWGEGDVFTYCHAGGLGDLLCNQVYPTTIVIDNNPPPVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXS3</accession>
    <name>H1UXS3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-rhamnosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05096</name>
        <name evidence="5" type="ORF">CH63R_01735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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            <begin position="24"/>
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            <begin position="380"/>
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        <location>
            <begin position="724"/>
            <end position="789"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYH3</accession>
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        <name evidence="2" type="ORF">CH63R_13949</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018308923.1"/>
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        </source>
    </evidence>
    <sequence length="206" mass="22950" checksum="97C331DE4662B141" modified="2012-03-21" version="1">MSSTPDPGLTFPQRGVVAYHTTHGPIHAPTLAALDALRARPDYDSCMPLLPDHQLSIDWDKIYSPSSYSSSLSSPPPPLHTPQAEIDATWDPYKLYAMIKRSQHDLAALQRRLLDVERAIYDADRVNNNAKRRETGVYPESWARPAATAVGPGARSRTATLAAEGTIPDEYELSRSWDVYKLREVFSEVQRNVDSAICGTRSQRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0Q2</accession>
    <name>H1V0Q2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Duf1275 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00150</name>
        <name evidence="4" type="ORF">CH63R_06968</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000902">
        <property type="protein sequence ID" value="CCF33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156721.1">
        <property type="nucleotide sequence ID" value="XM_018301943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0Q2"/>
    <dbReference type="STRING" id="759273.H1V0Q2"/>
    <dbReference type="GeneID" id="28866050"/>
    <dbReference type="KEGG" id="chig:CH63R_06968"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06968"/>
    <dbReference type="eggNOG" id="ENOG502S0ZW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061825_0_0_1"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="294" mass="31814" checksum="646641AA487ED033" modified="2012-03-21" version="1">MSTQNGLRVGDSSDTDHGNEQQTRDAPSKRTVVDWLRDDVNIRYTDIPVLACCLVSGLCDSVAVNAAGVFVSMQTGNTIFMALGASRLPAGEPLLWLKSLSSIAAFWLGCFFFSKSRHIHPKRRSTLALSFLLQASLIFLAAAFAQTRLIADFGATSVQGSDSNHEFKTSENPLVMVPLALLAFQFGGQIVTSRILGYNEVPTNVLTSVYCDLLSDPKLFAPLKENPKRNRRFLAVVLLVLGGILGGWLQRSQAGMPGALWISGAVKLIIAIAWMGWASNEPAESKLEKGVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0Q9</accession>
    <name>H1V0Q9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00157</name>
        <name evidence="12" type="ORF">CH63R_06961</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000902">
        <property type="protein sequence ID" value="CCF33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156714.1">
        <property type="nucleotide sequence ID" value="XM_018301936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0Q9"/>
    <dbReference type="GeneID" id="28866043"/>
    <dbReference type="KEGG" id="chig:CH63R_06961"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06961"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_dom"/>
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        <property type="entry name" value="MFS_sugar_transport-like"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Myo-inositol_Transporter"/>
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        <property type="entry name" value="Sugar/inositol_transpt"/>
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        <property type="entry name" value="Sugar_transporter_CS"/>
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        <property type="entry name" value="SP"/>
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    </dbReference>
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        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="120"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="634" mass="70229" checksum="853B30608EB316E3" modified="2012-03-21" version="1">MSTVHSADKTIHQNNTLGVEIDVSHKEHPNHGKLDDSHQTTGGLGNPLRNIPRDRLKAEASLFAVSLGWPSEIGLFQKAALVAQSPTVFEDIPELTEDDRSVLRNEVEHCWRHPFALYLTIAMNSISAAVQGWDQTGSNGANLSFPQAFGIEDKGQACLASGTCQRNSWIIGAINSSPYMAICLVACWLSDPVNNWIGRRGAIFVGAIFSIIGPIGQAISQTWPQILIYRILLGMGMGLKEVTVPVFSAESSPSSIRGALVMSWQLFSAFGIMLGFSANLAVAGYGEIAWRLQLGSAMIPAVPLLLGIYFTPESPRWLLKKGKYRKAYASLQKLRGNDLLAARDLYLIDAQMSMEQNLIQAQGFDKSNFFKRCVELWTVPRNRRATQASGIIMAAQQFCGVNLMSFYSSTLFEEAGASKTSALLASWGYGMAMFLFALPALKTIDRWGRRTLLLATFPNMCWAMGAAGLAFYIPKDSQAHLGVICLFIYLFAAFYGPGEGPCAFVYSAEVFPLSHREVGMAWAVATNNFWAIIVAQTSPPLLQAIDPQGVFSLYAFFNVICFILIFLFLPETKQRSLEELDGVFSISTRRHASYQLKEVLPWWFNRYVLRKGLEPEPKLYDFEMVENVESGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0W7</accession>
    <name>H1V0W7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_05967</name>
        <name evidence="7" type="ORF">CH63R_04879</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000925">
        <property type="protein sequence ID" value="CCF33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161100.1">
        <property type="nucleotide sequence ID" value="XM_018299854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0W7"/>
    <dbReference type="STRING" id="759273.H1V0W7"/>
    <dbReference type="GeneID" id="28863961"/>
    <dbReference type="KEGG" id="chig:CH63R_04879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04879"/>
    <dbReference type="eggNOG" id="ENOG502S1A6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_1_0_1"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="396" mass="43496" checksum="FCB2B6A0809C68E6" modified="2012-03-21" version="1">MANIPESDNVVRVKLIDTTTAMVGTAESFVQPVVPGHEVINFCSLAFLLENEALGKRAMFDLGVRKDYWNLPKAAQQGVLGPDSVIFGMSVEKGVDEVLRDGGVDPKSIDYCIWSHAHFDHRGDVSIFPKSTTLVTGPGYFSSKGRPGGRDDPQAAPEFEGRVLKEAEFDGGLTVGKFKAQDFFGDGSLYLLEAPGHQPEHICALARTTPSSAPGGATFVFLGGDICHFAGVFRPTADTPLPEGIPASAITRRSDWSSKAACPCSYFTPHHPNAKDEDSARTTPWYQLPRSGEHPVYVDIDLAADSVSKMRELDIEDNIMVCIAHDASLLDVLPVFNREPSRDINDWKKEGWKETTYWSWLNEVAVEGKTPRPPVVEGFWRDGKKWDYASHLNSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1U0</accession>
    <name>H1V1U0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_06236</name>
        <name evidence="16" type="ORF">CH63R_12994</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001048">
        <property type="protein sequence ID" value="CCF34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152385.1">
        <property type="nucleotide sequence ID" value="XM_018307968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1U0"/>
    <dbReference type="STRING" id="759273.H1V1U0"/>
    <dbReference type="GeneID" id="28872075"/>
    <dbReference type="KEGG" id="chig:CH63R_12994"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12994"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016758_1_0_1"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="442"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="148"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="394"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="532"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR03867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="742" mass="81565" checksum="9099BBA06E56B1B1" modified="2012-03-21" version="1">MADIEAVLAAKGNAQQTELSSETPNLPEGGNKFQHAISAWRTIDYTNLVSNLDNTASEIVTYQRDSTVQRKELAQKTKDFRKLDDSTKLTEIKGLLKAYQTFIDLLTNHSKSINSAFLQAYTSLSDAPDPYPLLEASVDSMLVSEDTLPKLSEENQHLQQSVTKLTTQLEDAESKLQTESAAKKELEISLESRVKEVEASWVAVLDEKKDNWAAKEKTLEEKVENQERLLTEIKASYEVNQRLGKADDGDTEAQAGHVTSAEIEMLHSDLDRTSARLAEVEARNEQLRLELAQAKSSVASQAPTSLEDDPGYMRMRSENSSLIRKLDAARVEKEGIKRTLDSRLRGLEREVGLLKEERDNLKAKVQKWSDYEDVKQELEVLKSIEFSTGDDDDVKEAAENLAEAKGQGDTLEKLLLARNKKLGDELTILRVSHQDLQTKLSDLQEDMSRTNMELEKAQQLNERLENDLATLQSESSNAFPSGASVAGTFNRYAPSAAPGRRGGRVSPTSSIISGIDPRMSGGEPMGGGSGILPMITAQRDRFKKRIAELETELSNTHRTVSQLRQEVSALQKDNLNLYEKTRYVSTYNRAGPSATTSSSAAYPSNPNPSTVSMGGSGNPGITMDRYRKAYESNISPFAAFRGRESARAYKRMSFPERVVYSVTRMVLASRTSRNLFAAYCVALHLLVFCSLYWLGTVDAEKHASNLGKSAAAAAAAGAGAGGLNGGAGDGHGDWQEEGFSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1V387</accession>
    <name>H1V387_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_06626</name>
        <name evidence="10" type="ORF">CH63R_11613</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Hansen M."/>
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                <person name="MacDonald P.J.P."/>
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                <person name="Hacquard S."/>
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                <person name="Torres M.F."/>
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                <person name="Buiate E.A."/>
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                <person name="Alkan N."/>
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                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
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                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
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                <person name="de Queiroz M.V."/>
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                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="86501" checksum="D5B71E0E4E3B5DA4" modified="2012-03-21" version="1">MDDPWGSPWATTDTTTAPSTSPSKDILEPPPPAFLSTPNNLNIPSSHSAWLDDDAFGDWASPDPGQASNSSPWTWGNEAAPIEGLTPSYEPRRKSSTPKWPRSRSPSPGRRPTLTPNTASPSQPSPDPWANHVSTYTRDEPEPLAQLPQIPDVPPLVLEPAHVGLGLSNALNASEQGLFAHEPITTQFAEPIPDSTQEQLQFSDTPIFDRFPAVDEQAGDAGPSSASAPSEDGDDNEEAQDARHSDSPITSIEEDSAAPNMSQRKVSGKVLELVEMYDGIAKRTTKTPELIAPRRSTSREPKATVQEARDRATEVDDLPETEKAAPPRISTKSGPDDLPENGNEVAGHVDEQDKPIRPDHDPFETDLGKLDILLPDASLDGSELPEDVPDRIIHDSFTSISERKMWYRLSRNESLRKHNAGDDENYVRINWTNSTLRQDTLKTVRRWIEEDSFGGRAFRSGSTRNAGGGKSFGWDATTAASPVDLDRVFGRKQKLKATVHRPTHSIGGLPSLSTAPMVPSSAGNTPVSSRPNDTWEGSATFGWSNEAGGGDGTKAETRGEASKHPAPRIPLPLAFTGFDNKPRSHASLPAFMIPTTPTPPVVNATTVKEEEADENEEDDEWGDMVSPTTAEATDSTSIPKTSWDSFSTNPLPDATTTPSSDSFTTSNHDADALGAGNNDKHDSRDKSGLEDIGSVISPTPASTPRPAAAGVPQSQGGTSSPPASTYTFRPASAVKRPANISIAATLTDPLAPLTSVKAGVSAGGLVETPLRTGPDTSSTAQPRNSAEEFALVQHFVRELPDLSYMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1V477</accession>
    <name>H1V477_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_01234</name>
        <name evidence="2" type="ORF">CH63R_01792</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001369">
        <property type="protein sequence ID" value="CCF35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161583.1">
        <property type="nucleotide sequence ID" value="XM_018296767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V477"/>
    <dbReference type="STRING" id="759273.H1V477"/>
    <dbReference type="GeneID" id="28860874"/>
    <dbReference type="KEGG" id="chig:CH63R_01792"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01792"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075862_0_0_1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="26371" checksum="91ED3359701AF01E" modified="2012-03-21" version="1">MDIETLIMHAPFKLSDEDIRVLRGQSERLEPHTWDEVKGMIAAGEMGQLRRSPLDLRNYIRWHAEIGKTHGSVLEYVRHERLHWPKHIIARDAVPFAHANDWKIIWNDWPYDLADGMMHLVIWSKSRTAVDPETGLPTDHTAKLIESFLDRTFGETLGCRRGQDLLWFKQKTAWQSVKALEHIHVLLRNVPEERVEKLVGQRRSQTLRALVGESMASIETRISSKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V622</accession>
    <name>H1V622_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07405</name>
        <name evidence="4" type="ORF">CH63R_09391</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001639">
        <property type="protein sequence ID" value="CCF35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156388.1">
        <property type="nucleotide sequence ID" value="XM_018304365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V622"/>
    <dbReference type="STRING" id="759273.H1V622"/>
    <dbReference type="GeneID" id="28868472"/>
    <dbReference type="KEGG" id="chig:CH63R_09391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09391"/>
    <dbReference type="eggNOG" id="ENOG502QPW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047439_0_0_1"/>
    <dbReference type="OrthoDB" id="5230543at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="395" mass="44604" checksum="5B26919B8773EB0D" modified="2012-03-21" version="1">MNFPTSSANDFAFTLNARPDAQLQQQQNHHPQQQAHFSSRHLQQQQQQLLQLHQQQHPLPPPPSPPPASSATAQSFTAAQQAFAHAQYQQLALMNGMNGGNVPNGMGGMPTPAGQQAELNYIYGMVEELSRQLAENRRVTEDIVSGLGRVRSRARTQGMSNEDLIHNAADDIRAQERNLDNFISILSESLEKAKYSRDANATLLTQYATVLAAMLKQFHEYKAKHVTDVAAWHRSYRSQLAEARAENSRLREQIWEMQERAGKANEALRKFRRKYDENEARWDRRVEEVAARQELRFWKRMAMPEVSDDDPCWSDDDDLIDSAEKERLKELEKRVAQEQLAGSQQMGEEYSRPQSPESSMMGGVPMQRDLGIPMPMPVPPPRPSSATSSTGSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6E7</accession>
    <name>H1V6E7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07506</name>
        <name evidence="8" type="ORF">CH63R_09106</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="CACQ02001700">
        <property type="protein sequence ID" value="CCF35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156103.1">
        <property type="nucleotide sequence ID" value="XM_018304080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6E7"/>
    <dbReference type="STRING" id="759273.H1V6E7"/>
    <dbReference type="GeneID" id="28868187"/>
    <dbReference type="KEGG" id="chig:CH63R_09106"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09106"/>
    <dbReference type="eggNOG" id="KOG3323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_0_4_1"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="174" mass="19203" checksum="0A6F9E470C3FD40D" modified="2012-03-21" version="1">MKAIVQRVLSASVAVDNEVISSIGKGILVLAAVAPGDTEKDAETLANKVLKLKLWDDEAGARWKKTVQDIDGEVLCVSQFTLFAKIVKNKPDFRLSAPAEDAKRIYHYFLQKVQDNYEADRVKDGRFQAMMAVSSTNDGPVSAPFGTRRNYPGLRADLQCQITFELNTEPASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7W7</accession>
    <name>H1V7W7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH063_07913</name>
        <name evidence="21" type="ORF">CH63R_10576</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="CACQ02001926">
        <property type="protein sequence ID" value="CCF36319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154974.1">
        <property type="nucleotide sequence ID" value="XM_018305550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7W7"/>
    <dbReference type="STRING" id="759273.H1V7W7"/>
    <dbReference type="GeneID" id="28869657"/>
    <dbReference type="KEGG" id="chig:CH63R_10576"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10576"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_1_1_1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="127"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCF36319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="510" mass="54995" checksum="8C0B9E90FD7F012E" modified="2012-03-21" version="1">MTTKTQEPERATISLTDLSKHNTKADCWIAVHSKVWDITDFINDHPGGPSVLLKCAGSNATKIFDEVHAPDILEELPDEKLVGVLQDATPDVPAASSQSGGTNGTTKASAETVQAASTSTQGQNAIPPLDSIIGAPDFEDVASKALTPKTWAFYSSAATDLITHKNNKELVRRIMIRPRILRNVSHIDMRTTILGFESSAPFFISPAAMAKLVHPDGELALSRGAANENIIQCISSNASYTLKSIVSAAPPTQPFFFQLYINSERHKTIEILRSARALGIKAVFVTVDAPVPGKREADERAAQAGTIRAAISGAESSKDKKGSGLGRLMAQYIDKSITWEDLSWIREASGVPIVLKGVQTADDVRLAVEYGVDGVLLSNHGGRSLDGSQASILVLLELREQCPEVFDKLEVYIDGGFERGSDILKAIALGATAVGVGRPFLYSLVYGQPGVEHLSQILKDELETSMRLCGITSLRQATPAMVNTLDVEYLVVSEDRARQKKPLGRPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V806</accession>
    <name>H1V806_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07946</name>
        <name evidence="3" type="ORF">CH63R_07768</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001943">
        <property type="protein sequence ID" value="CCF36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR09003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="chig:CH63R_07768"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07768"/>
    <dbReference type="eggNOG" id="ENOG502SII2">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3926760at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="135"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09003.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="384" mass="41536" checksum="CB7770DC0CF7B3F6" modified="2012-03-21" version="1">MPPANNGALASAGVIAVSVAVAAAIAIYESPELRRYADDIRRRIAVALHSLGEGIEPGEQPPMFNRPEDAQGFLESRGGAEPGVDADDETRRRQREELLYWNAVHLAKKEKDRIEAKESGSRELPPLGPTRGRSFDDFMRQDQTGEKGSFIFNTGANVHDEEGLVRRRPEGVRGLNSSLYANPFADEHQIDQDELPLVDEPSHLAPGRDEAVSDIYSATTHDADERPRDFTATTIAQMPSLVDVVETSSESEKSATLDRELGPDEYMTAGQENREEAYASIQAWAQGSTASNFYSPLPMSPPVPMSEPELVSEGELTPTDSASLAGSGEDVANDAASSGAGDNSRYYDVLSESEGMMTPASWSEVGSVISENETQDATHGRVHA</sequence>
</entry>
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        <submittedName>
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        </submittedName>
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        <name evidence="5" type="ORF">CH63R_00006</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002010">
        <property type="protein sequence ID" value="CCF36501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163343.1">
        <property type="nucleotide sequence ID" value="XM_018294981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8E8"/>
    <dbReference type="STRING" id="759273.H1V8E8"/>
    <dbReference type="GeneID" id="28859088"/>
    <dbReference type="KEGG" id="chig:CH63R_00006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00006"/>
    <dbReference type="eggNOG" id="KOG2305">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009834_0_1_1"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
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        <property type="entry name" value="3HC_DH_C"/>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
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    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF36501.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="321" mass="35174" checksum="94BD204BFDC9A1D9" modified="2012-03-21" version="1">MRDIRNVAIIGCGSIGASWAALFLAQGLEVTAFDINPAAEVFLRNLVTDALPVLSSLGLVKNANAHASGIRFTTNMTEALADADFVQENGPEKLDFKRKLFNDMAAIVHPDTIIATSSSGLTCSSIQEGMHATSHPERCVVGHPFNPPHLIPLVEVVAGNATSPDTVSSTMQFYENMGKKAVHVKKEVVGHVANRLQAALMREVMYLLQEDVANVEDIDKAMSYGPGLRWGVMGPSLLFHLGGGEGGVEYMADHLLAPLMSWYAPKDPEVTDELKQKWVSGTMQAVDDREYRQLARQRDEELVRLLNVRKEWDSFAADSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">CH63R_11169</name>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
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                <person name="de Queiroz M.V."/>
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                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
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                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
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                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
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                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
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                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="383" mass="41440" checksum="74802D6C1C626922" modified="2012-03-21" version="1">MTFGGPTDRRGVTPEDKKPKKDDSPTISVASPGPVVNPLDDSAREAFATGRPLEDTPDLQQCKHCKKSILKTAAKAHIAQCLKLKKEKAQRKKEAREARERAKEAAREEEARKADEDADGKGEDDSDGEEDGAEKKATGSKTTKKAAGKKTDGDTSKGKKRKADGDAEKGPKQKKKKEEPKPKAPKPKGPVDVERQCGVLLPNGQPCARSLTCKSHSMGAKRAVAGRSLPYDMLLAAYQKKNQAKQQKAALDANAPLEDEDEANAGPVDSDEETAAVMSALAHWNPQPVVPQPLLNPIKRQYQLARLHEQLQMATNGGRTNIFKVNGFGVQKLPYGHPGLMDTEDAPGELDTADLNFGGARRSSSFSMQSQPPQRRPSVTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCZ2</accession>
    <name>H1VCZ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_09271</name>
        <name evidence="9" type="ORF">CH63R_08566</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002801">
        <property type="protein sequence ID" value="CCF38095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155563.1">
        <property type="nucleotide sequence ID" value="XM_018303540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCZ2"/>
    <dbReference type="STRING" id="759273.H1VCZ2"/>
    <dbReference type="GeneID" id="28867647"/>
    <dbReference type="KEGG" id="chig:CH63R_08566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08566"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_0_1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF38095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="44161" checksum="AAEFDEB3A57431D4" modified="2012-03-21" version="1">MAAEAPIVLDGGTGFLKVGYAAQNFPEFQYPSIVGRPILRTEEKGEDNDVVIKDIMCGDEAAAARTMLQISYPMENGIVKKWDDMQHLWDYTFFEKMKVDPRGRKILLTEPPMNPLRNREQMCEVMFDRYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKRLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDCEQPGIAEFLFNTIQAADVDVRSSLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTRVLGGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANIMADKEGMWVTKEEWDEQGPRVLEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDJ8</accession>
    <name>H1VDJ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09420</name>
        <name evidence="4" type="ORF">CH63R_10494</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002905">
        <property type="protein sequence ID" value="CCF38301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018305468.1"/>
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    <dbReference type="STRING" id="759273.H1VDJ8"/>
    <dbReference type="GeneID" id="28869575"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
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        <property type="entry name" value="ACOT8-like_C"/>
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        <property type="entry name" value="Acyl-CoA_hotdog"/>
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        <property type="entry name" value="HotDog_dom_sf"/>
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        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
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    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
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    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
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    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF38301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06374.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="321" mass="35612" checksum="B4FA864406CF24BE" modified="2012-03-21" version="1">MSASEELVPLSEATRITRLDSNVYGANLASGWCIGSVPNGGYVASVILRAASLHLAGRGQPDTISAHFEYVNRTEIGPAIVVVEEVKIGRNLSTVHVSLYQHDLQSSAPWFTPKSRKEVVGYFINTLLTVEKGLTLKTAWSMTPPTRPADFALLALDKDPHWAKRARLNARATSFARSHNNLEHYLPREGTPRGISDVWMRLKSGERFTNASLGYVVDANPTVIEAWRPRPDEEQTPFRSGEMFWYPTLALNLDVKKALPADGAEWLFIRSMAKVIRNGRLDLEVTVLDESGDVVALSTHVNMVLPAERNMKERSHVAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDM3</accession>
    <name>H1VDM3_COLHI</name>
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        <submittedName>
            <fullName evidence="9">Cytochrome p450 family protein</fullName>
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    <gene>
        <name evidence="8" type="ORF">CH063_09438</name>
        <name evidence="9" type="ORF">CH63R_13196</name>
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    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
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    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
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        <property type="protein sequence ID" value="CCF38326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018152587.1">
        <property type="nucleotide sequence ID" value="XM_018308170.1"/>
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    <dbReference type="STRING" id="759273.H1VDM3"/>
    <dbReference type="GeneID" id="28872277"/>
    <dbReference type="KEGG" id="chig:CH63R_13196"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13196"/>
    <dbReference type="eggNOG" id="KOG0684">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:heme binding"/>
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        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="484"/>
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        <ligand>
            <name>heme</name>
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        <ligandPart>
            <name>Fe</name>
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            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF38326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="550" mass="62308" checksum="68A06E2DA459A351" modified="2012-03-21" version="1">MTVTASAPFQFAVDHPLVTIIAVIASLCVLVAQRSSQDAPPSLPEALPFISNTYQYMTDLPTLMDRVSHAMKRSDVVRVWLGPMRVYLVKGGESVQAMFRASSTFSYEKFILMVIKNLQGSSKEDVGKFVNDKSGVSKTPAPGWEDLPPERRYWYQIHHLAVDNLSRAGPTGHLIGLYTRFLGEALEKQPLGEWATVRLFDLLREDMGESALRSLCGTRILEVLPDYIQQFWRFDSIGFQAVYGLPKWINPKPAEERDRLSDMTQKFLKEAFATFDWDGPDAESDWEPILGSRYIRLLLKWLADSDMTMRTMAGFHMISVLGVNANTIPVTAWAMMEVLQDRELLEAVREEALQAMVRDPATGERSFDAAKLVSMPLLQSVYVECMRLHVSIAITREVLETTTLRGFRLEKGSLIQAPTNLMHFDEQVWGHEEHPATEFWAGRHVKQAEGLDEEGTGRVSAKRQFVMAGKPSEFFPYGGGVSICPGRFIAKQEIILTIAMLVTRFDMEFVEWTCEDGSKSDRPPVDDKHYFGSAAVPPDRDVRVRWKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VE34</accession>
    <name>H1VE34_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09571</name>
        <name evidence="3" type="ORF">CH63R_03998</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002997">
        <property type="protein sequence ID" value="CCF38487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160219.1">
        <property type="nucleotide sequence ID" value="XM_018298973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VE34"/>
    <dbReference type="STRING" id="759273.H1VE34"/>
    <dbReference type="GeneID" id="28863080"/>
    <dbReference type="KEGG" id="chig:CH63R_03998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03998"/>
    <dbReference type="eggNOG" id="ENOG502SJXQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057891_0_0_1"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554900" description="Secreted protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32502" checksum="C3C769296405A2BA" modified="2012-03-21" version="1">MPLSTYLVQAFIAAFVVLFGVQMQTAAAQATPSTCVTVDQPNPIFSQYPNNATGLLNVTMAIIPISMTTARQIIPQQYGILEGAFRALMPDFPAGMYPVIVQAGHDHDIRFQDFQIPDFSRAGFEFPFLDLLGDGASSFRWAPEQLISATNAAAITGSEAYGTKVHAATFGPECDAYRALPQGGGTYFNGSAGDKYVSLEMKRSCEGQASPYSLGMFDSIINQPIFANGSACDQQIRFFNTTVTKGAFEPVAVRGTVKTSIGPFGTEASFTDVAGFQAATAFIENNYLPCEMFRGYVPVKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFL3</accession>
    <name>H1VFL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02036</name>
        <name evidence="3" type="ORF">CH63R_11281</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003268">
        <property type="protein sequence ID" value="CCF39016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153096.1">
        <property type="nucleotide sequence ID" value="XM_018306255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFL3"/>
    <dbReference type="STRING" id="759273.H1VFL3"/>
    <dbReference type="GeneID" id="28870362"/>
    <dbReference type="KEGG" id="chig:CH63R_11281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11281"/>
    <dbReference type="eggNOG" id="ENOG502RW59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003953_2_2_1"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="624" mass="71295" checksum="87A46A4DA61E1518" modified="2012-03-21" version="1">MSSFRPEWLIDVVRGCVVPCDERTSRFLTLSYTWGRTKNFRTLKSNLGAVRQPGALFSGPIASEVPLTIRNAIRLTEALGETRLWVDSLCIVQDDSLALAHDLRHMHRIFASSFLTIIAKDGQDAGYGLRGLRGISPPRATKQHVVPLAGGERLATMNNSEPGKEPEVYDYDQRMWTFQEKMFAKRQLIFANGSVIWQCNCVQWSEHVTSHAEADRRGQMMQDEELSMSVPSLSLNSLVVDFNRRNLTFDGDVSAAFSGISTYLERRFPYGFIAGHPEFFFDISLLWHSSGRLRRRRPLGESSEEPPMTTGPPSWSWMGWQGVTYFPHDLEYEYSLSGPTGFTAPLTEWFILETPSSAARRQINSRWHQYKKASPSRLLEGWKATEFVPPPTWDAFNVLNNELIPTGTPRHIPKTFYTHVSEPQPQRLKKFWYQVPTVDVGTLQSQGTEPHRHFQYTCCKTSRAFIKASYDADWESCRNVNISYLQDNSGATVGILKLPHSVDVASQQEPKVELVAIVKGWSSLLDEFSEKNKTTALRNRSQEDIQLTAEEEEAERKLMALSRGDRHKSWQEKWDIHDKLKLDCCFVLWVEWKDGVAYRKGSGMVLADRWDELKEAEEVDLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFL7</accession>
    <name>H1VFL7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pectate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_09965</name>
        <name evidence="8" type="ORF">CH63R_11165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003269">
        <property type="protein sequence ID" value="CCF39020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152980.1">
        <property type="nucleotide sequence ID" value="XM_018306139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFL7"/>
    <dbReference type="STRING" id="759273.H1VFL7"/>
    <dbReference type="GeneID" id="28870246"/>
    <dbReference type="KEGG" id="chig:CH63R_11165"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11165"/>
    <dbReference type="eggNOG" id="ENOG502QR5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_0_1_1"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497664" evidence="5">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF39020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="35186" checksum="714BCDF875AB6370" modified="2012-03-21" version="1">MRLNAPALLCAFASLATANPLDWLGIASWDVEGFAKDNPIGKTTGGKGGPTVTVTSVPELQTAVVGSDPKTIVLKGEFALPARLNIGSNKSLIGFKNKPERNLKISFILDNDCITIRNSTRVWVDHNEFTSDISQGPDLYDGQVDIIRASDWITVSWNYFHDHWKSSLVGNDATFRDLDSGHLHVSYHHNHWKNMGTRGPAGRFGTQHIYNNLYEDFLYQAIHSRSDNQVLVEGNVFRGKTREALSTYGLVIPEDSPNTCVCGDEELDGFANLGSPNDWGRAGVNITQKGTFYKAPYKFKLTPLPLLAPIIKLGAGVGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VG93</accession>
    <name>H1VG93_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_10124</name>
        <name evidence="11" type="ORF">CH63R_02485</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003388">
        <property type="protein sequence ID" value="CCF39246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162276.1">
        <property type="nucleotide sequence ID" value="XM_018297460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VG93"/>
    <dbReference type="GeneID" id="28861567"/>
    <dbReference type="KEGG" id="chig:CH63R_02485"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02485"/>
    <dbReference type="eggNOG" id="ENOG502S1QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156745_2_0_1"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF39246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="98" mass="11271" checksum="F5B59A27E6AF4FBA" modified="2012-03-21" version="1">MGGLNLEVFKFGMYVMFPIGIMYYFGTNLDSRFAVPDFWPKAEHSHKIPFDRDEIKSEYVRLAKRQRAVEEMRREREAAQAAQAAQAAQNPPSNGEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGL4</accession>
    <name>H1VGL4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_00318</name>
        <name evidence="15" type="ORF">CH63R_02787</name>
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    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="CACQ02003457">
        <property type="protein sequence ID" value="CCF39367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162578.1">
        <property type="nucleotide sequence ID" value="XM_018297762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGL4"/>
    <dbReference type="STRING" id="759273.H1VGL4"/>
    <dbReference type="GeneID" id="28861869"/>
    <dbReference type="KEGG" id="chig:CH63R_02787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02787"/>
    <dbReference type="eggNOG" id="ENOG502S2ZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038298_2_1_1"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="295"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF39367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR14061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="42088" checksum="CFA50BCD927494E7" modified="2012-03-21" version="1">MADPVSPPSSPPRDSNTTPSTTNNEKTTTHTPVTPENKRLSQIGGLSFAERKMSRRPSTAPTPIVEGDGGLTRDVHHSLPGDARNNRKSRTQADMAKRRSSYYEEAFQGDREANVVKDRIYGEAIVMAELRTNVIINDEFSFITDFSYQLSIRYQRPVHSIVVNLQHGACMLFGGTFEPAYTLSVHALPVEVGVTKNKRNTALIQKHLQESLGVAPVRGFVKFVEVPAENMAVNGKTTASHISEMTGEEDETIAERRARNRKSISAKSISALRHGSIVGPRKGSVFDFRRESVAAPRKESVMAPPQELTPPHSATDAPPIPPIPEAHVVNNTGPASAEKEAPIKEVEKAPTNNQLAPPKKAKRKSSFVSSLFSRSPKSAPMSTVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VHQ8</accession>
    <name>H1VHQ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00330</name>
        <name evidence="3" type="ORF">CH63R_01491</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003680">
        <property type="protein sequence ID" value="CCF39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164828.1">
        <property type="nucleotide sequence ID" value="XM_018296466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHQ8"/>
    <dbReference type="STRING" id="759273.H1VHQ8"/>
    <dbReference type="GeneID" id="28860573"/>
    <dbReference type="KEGG" id="chig:CH63R_01491"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01491"/>
    <dbReference type="eggNOG" id="ENOG502SPBH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="292" mass="32126" checksum="F31FBC7D4CC93163" modified="2012-03-21" version="1">MPAQIGENGSSTEVGQSKNQYLAMVGDIQAELTRLQVQHRWIQMCLQDQIAFAPVDLTKDGVKVLDMGCADGTLLRDLYKQVPPSAQMVGADISTVFLPTSPQGNIRYVTQDVCDPPAAELRGRFDLTHVRNVLHSANRSGVQQAVANLADTLAPGGWLQVMELDIIPGQSEQPQALQDLVQMIGYMFEKQGMDRNYASKIPGSMKKAGLQNVTVEKVECGIGRVHGDEAAVRSSIEPFMHMIPLVARSAKMICPDLDPKIYANLEARYVREMTEQGGYFPANIYYAQKPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJT2</accession>
    <name>H1VJT2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_02366</name>
        <name evidence="6" type="ORF">CH63R_12922</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02004112">
        <property type="protein sequence ID" value="CCF40485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152313.1">
        <property type="nucleotide sequence ID" value="XM_018307896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJT2"/>
    <dbReference type="STRING" id="759273.H1VJT2"/>
    <dbReference type="GeneID" id="28872003"/>
    <dbReference type="KEGG" id="chig:CH63R_12922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12922"/>
    <dbReference type="eggNOG" id="KOG1602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_0_2_1"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF40485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="360" mass="41197" checksum="7C5842F76E3A9ADA" modified="2012-03-21" version="1">MSEIFINHITRWLFSSPPAEWAINQFRELLIGALKQGPVPQHVAFEMDGNRRYARGKKMETIEGHHHGFEALARVLEICYKCGVKVVTVYAFSIENFNRPQYEVDGLMQLAKVKLEQLTKHGDILDRYGAAVRVLGQRDLIRKDVLEVVDRAVDMTKYNKRNVLNICFPYTAREEMTTAMRSTVQEYMMPPGPKFTPFPAARISQKIMSKQLDRREPLPTIRDTSPAPSSRSDGDDGASSSTTLPPDSPSPPSHRSGSAGGHHLKNPETITAETLNNHMYTAGNPPLDIFVRTSGVERLSDFMLWQCHQDTHIFFLKCLWPDFDLQHFLPVLLEWQWRQKKQIETEERPRQATVKARKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKG7</accession>
    <name>H1VKG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ calmodulin-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11209</name>
        <name evidence="4" type="ORF">CH63R_10867</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004252">
        <property type="protein sequence ID" value="CCF40720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155265.1">
        <property type="nucleotide sequence ID" value="XM_018305841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKG7"/>
    <dbReference type="STRING" id="759273.H1VKG7"/>
    <dbReference type="GeneID" id="28869948"/>
    <dbReference type="KEGG" id="chig:CH63R_10867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10867"/>
    <dbReference type="eggNOG" id="KOG1981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005050_0_0_1"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF40720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113746" checksum="AE5BEBFF1B09C910" modified="2012-03-21" version="1">MRRPSADLTDPSRNLEESVGSPSSTLEPPDVDLSMPPTSDEEMDDAIDDADGRIFTPPPHIAARFYRPSQARRKDSAASSRRNSISSVHSRCSSTQTFNRHGAPQSKQIAQHLRRTSFLEDRKARLADRAAHAEKVRLRAAMAKANHRDTSLSEERALAAQQARERNLAEIVASCAEEVKRAKAVAETMKDKRERELVKLRIQMEERLAEAERRREELKNRHATKRARGQSLVSRKTTETSSNPADTDADVDVDADADADASPLSETDAAARLQWWWKSHMRKKAVANFSELGLTIEGVRDTSFDEVLELLGQEKVLVRTARILRICGLQEGDTGSVDEMAAVRTFLSAFLILGHPTQVLSNKDGTGNREQVGLLQPQPLPSNDLANPQLQDLVTKARDLLISFENIMSRLTAANNYTPPPTLRSALPEIYATFYNAFLAWKSRDSESLVQLMLLQFVELDMILQTVQESTDDAAAEQYRESVKSNQVQLIVRIKKLAGQERGKKMIADAVRKARKARAAKKPTGDMKPRVAENAPGEASATAESLVSPELQTQTLTPPPTPAKGHTKPQPIEIKPGFSGLLPDNRIVVHELAINREYRIPASEYREHRTALQIPLFAGMRASMAEDNLDASFGYFIIMMRYLKDNLQRLVKAGAYMHNTIGEILDVEVAERQFQMGSFSYEKFFVSMASLLPKLCAPFRDDEVKDLVDNKLQNGSLVDRVEALTEFVDLMLCDYVNYMFSTAAPQLIESAPEYEKKRFATALESGQHGLNAAEAAWRTARSKVLAEARKRDPEGINHAKSRPTDDKIYAQLLVDCFTQPAPIAADTVPEMLGLDYKRMTRLSLTSQRIVTTGAILLQCKNLLKRDVRTPWKTEATRITAVLEADHENIDSIVQGVMAALEGGRSMPAATKTHLKALVTKVLKASHDSMKKGVEPTEPVLRLLLARLRGHMNARLTAGSAKEKLNAATTAHEKLAGLGLAEFAVQAREMLDEISKVGAVDRAAHGLWWNEVAAKVAAEGEAGNGSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLX9</accession>
    <name>H1VLX9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_11570</name>
        <name evidence="12" type="ORF">CH63R_10880</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02004569">
        <property type="protein sequence ID" value="CCF41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155278.1">
        <property type="nucleotide sequence ID" value="XM_018305854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLX9"/>
    <dbReference type="STRING" id="759273.H1VLX9"/>
    <dbReference type="GeneID" id="28869961"/>
    <dbReference type="KEGG" id="chig:CH63R_10880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10880"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_1_2_1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010895402" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="425"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF41232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="484" mass="52133" checksum="40E0234A6FE6C720" modified="2012-03-21" version="1">MLVQTALVALSATLAAAVKPLTVKGNAFVNDAGEKFQIVGVDYQIGGSAAYDPVHNRDPLSNGDVCLRDAALLQRLGANAIRVYNLDPNLNHDACASIFNAAGMYMILDVNSPLPGESLTSVEPWTSYYAAYLNRTFAIVESFKSYPNTLAFFSGNEVMNDVKTAEFVPQYLRAVTRDLKNYVSKHADRPIPVGYSAADVREILVDSWNFLQCAENGDEKDPSRIDLFGLNSYSWCGDSDFKKSTYDQLVSDLKESSVPIFFSEFGCNQVTPRVFTEIGAIYGPDMKDLFSGGLVYEYSQEDNNFGIVKVNDDKSVELLIDYTNLATQYKKVDFKSLQAEKAPANSPKPPKCESSLIKEKGFNNNFTLPDVPPGAQELIDNGIKNKPSGKIISISDWTVKHKVYDVGGKTEITGLAVSPLADSDANTPGTNTGGSTAPAASSTSTPTGTGTASSSTPSTSNNPAVPLRPKVAAMAAPLLALLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VM84</accession>
    <name>H1VM84_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11650</name>
        <name evidence="4" type="ORF">CH63R_04569</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
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                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
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                <person name="Sykes S."/>
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                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="954" mass="107511" checksum="0CD67045A6EC4D3B" modified="2012-03-21" version="1">MTKARAARGNQPIKSEPGALRHHNPHHHNNPSPSHSPSVTNTYNGSPEQTRDQASSYAAPIDVNQSFLRSDAPSISVRNNQGLNSVQTALTNPTFDESEPVLLQVRNRDMDPPVVTMQNDSFLDGSFRDIGAKVKIFNDTLGELQQLGVSHDVALPQLVLVGDQSAGKSSLMSGLAGLNLPRSEGVCTRCPIHIRVSRSGARDRGGPEWSCRVSLQQDYAFRPPPNYNLTKAHVTAENPFPPWVKQPRVVKEFMTIYDQSDIDTVLKWAQIAILNHDQNHQLYIPGTGAITKQSLLDDEAERTLAKFSPNTVALEIKGPDLPDLSFYDMPGIFRNSAREEDEYLVSVVENLARQYISHAGALIIWAVPMNVDPETSSTLSIIRDLRAQDRTIGVMTKADLLPEGNYNQWISMLLGERHKIGHEFFITSRPSDKNLDEQQRWEDALFHQNGSERWPEDFHVFRPRSGVEKLKTALSEKLGKEFAKNLPFIKQKVQARLGEIEGQLSTLPELPNNVELEVRKSLMVFSATVKDTLRARHFSSNYGSLSDCFRDCILQMKPKFVLKDKSDIPVLEISDDDEEAANVTPGNRKRSANGHGQTSSKRQRPTVNGGSFSAAIKTEDGGSTPSTPSRRRPPPPAPLVGSFQQYFNYGAGFRTLAQIRDDIRAKTKAGMPSIVPDEVYEDLCKKAVRDWDKPMATFLHETMSRLQKIVDYALNQAFGSLKKRLIFKESKALMNEFLNVRRAEAMAFLKEIFDMETHQLFTVNRKAFEDYERSESLVLTRYRHVMRWQAFSGEQSDFHDWDKMTPDQRHSEEKKHNSELTKMGSDPFDKELKVAAYVRGYYMLSALRFADTVCLSITSRMMPKIVQDLDFFLEKKLGLAGGHDDTVFTRLMEEDEDTAHNRERLKGELEKFKKALQSITTNELEGASGSSSLEQTQFGSYAESMADSMDMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VS16</accession>
    <name>H1VS16_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_02972</name>
        <name evidence="6" type="ORF">CH63R_12167</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02005802">
        <property type="protein sequence ID" value="CCF43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153982.1">
        <property type="nucleotide sequence ID" value="XM_018307141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VS16"/>
    <dbReference type="STRING" id="759273.H1VS16"/>
    <dbReference type="GeneID" id="28871248"/>
    <dbReference type="KEGG" id="chig:CH63R_12167"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12167"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_1"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="259" mass="27952" checksum="631A7EA81C56437B" modified="2012-03-21" version="1">MATSPSRRLIGLSTKMYFPLQRTLDFVAAVQTELKALPPHALDNVDLFIIPDFVSIHPVNEALKSSPVPIRLGAQDCHWDDFGAFTGEVSPAVLSETGVTIVEVGHAERRRLFGETDEVVAKKAAAASRNGMTPLICIGEKTKRDLDVALSECKAQIDQSLADVPDSAEVIVAYEPVWAIGASQPASEDHVIQVVKGIRAFESVKRRTGTTRVIYGGSAGPGLFERLGEAVDGLFLGRFGHDVPRFLKTVSEVAAFQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VS64</accession>
    <name>H1VS64_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_12881</name>
        <name evidence="5" type="ORF">CH63R_03595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005837">
        <property type="protein sequence ID" value="CCF43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159816.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VS64"/>
    <dbReference type="STRING" id="759273.H1VS64"/>
    <dbReference type="GeneID" id="28862677"/>
    <dbReference type="KEGG" id="chig:CH63R_03595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03595"/>
    <dbReference type="eggNOG" id="ENOG502RYMZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005679_13_5_1"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0016747">
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        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF126">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
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        <location>
            <begin position="347"/>
            <end position="367"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="411"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="87"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="57833" checksum="DB637F50727B523C" modified="2012-03-21" version="1">MISIAVRSIRGAIARFSPPASFPYSPLADANSHSEPPSPGGSGSGSQSKSKSIFARLLALLFFLLPSFVQRRLRPNDFKHRRIYPTSWLDGLRGVASLIVFFCHFTEKHAAWFTARAYGIPDENDNVASSPLQLPFVRVIYSGRPMVHIFFVISGFVLSLKSLKQARKRDYDGLHRTLSSSVFRRGFRLFLPTTASTFIIMVMIRLGWTGSPLPTLWEQLVDWKNAVWRITFSWQWDITQILPYDVHLWTIPIEFSNSLLLFIVLTGLSRMKTYLRLASVLAIMVYCLKCGHWAAFEFLGGMGLAEVGLIQEARRERLTFAIQDKEASDMEASVAPDSTSTSMATRLFKAFLVGNLIFALFVAGWPNQKADVTPGMSPLWHNTMEPFFTMGGDLVSFPWYALGAMQIVAALQQIKMLQNIFVTPLAQYLADISYALYLVHGPVLDVFSHRWMPVAWSLVGGSNEAGVLGRVVAWVVGVVALLVPVVWASDVFWRTIDVKSVELAHWIEARCIRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VUP8</accession>
    <name>H1VUP8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_03203</name>
        <name evidence="10" type="ORF">CH63R_13709</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02006512">
        <property type="protein sequence ID" value="CCF43957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151001.1">
        <property type="nucleotide sequence ID" value="XM_018308683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUP8"/>
    <dbReference type="STRING" id="759273.H1VUP8"/>
    <dbReference type="GeneID" id="28872790"/>
    <dbReference type="KEGG" id="chig:CH63R_13709"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13709"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013227_1_0_1"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="183"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF43957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR02483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="821" mass="91672" checksum="532B2115140ABE27" modified="2012-03-21" version="1">MRLFALHPRDALRRAGTRGIHHSVTVGRIRTHGLLVHRRPTLSRQSQHGFFTAREKIPTKKKSIPVALLTGGLLVWWLYPSEEFERLSLAEEDRENKIRDRQAGKVNGGSNGAAWYNFTLKFQTLSDATDIEWSADKIVGFILPEWSRLIPGYIRKLQRELSMAPGSLADEIWREAHDPFVNPEVQYAANVRVSNDLCEEEKEFLARRKRVTTMALAKYLELDEKDVHPEDVPTIAMCGSGGGLRALVAGTGSMLAADEDGLFDCVTYTSGVSGSCWLQVLYHSSISEGSLGRVLQHLKARAGVHIAYPPVAFQTLLSAPTSKYLLSGLVEKLKGDPGADFGLVDVYGLLLAARYLVPKGDLEVNDRDFKLSNQRDYVKYGQNPLPIYTAVRHEIPDIDLDGSGEVPSTSDAAKEVAKKEAWFQWFEITPYEFFCEEFQAGIPTWAMGRRFKNGVDVPPEEGFHLPETRMPFLLGVFGSAFCATLSHYYNEVRPLVQSIAGFSSLDGMISGYNEDLSKVHPIDPGTVANFVYGMEEKLPKTTPQSACRSEYIQLMDAGMSNNLPIYPLLRPGRDVDVVVAFDASADIKTDNWLAVADGYARQRGIKGWPVGVGWPKAGESPKQVRDELIESEAASAKDADQKLRDAKKFQREHETKESNPNEDTERGQAAKFSPGDEEAGELGYCTVWVGTTQERVSEPPPPSKAITEANHWQIMEPDAGIAIIYLPYLANPQVPGVNPGTTDFLSTWNFVYTPEQIEQVAALARANYAEGREQIRGTVRAVYERKKKLRLDREEKSRRDRYRKLVRQGMAHKLGEGDQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVE6</accession>
    <name>H1VVE6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_03271</name>
        <name evidence="12" type="ORF">CH63R_02261</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006701">
        <property type="protein sequence ID" value="CCF44206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162052.1">
        <property type="nucleotide sequence ID" value="XM_018297236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVE6"/>
    <dbReference type="STRING" id="759273.H1VVE6"/>
    <dbReference type="GeneID" id="28861343"/>
    <dbReference type="KEGG" id="chig:CH63R_02261"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02261"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_0_0_1"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="95"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF44206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="620" mass="68680" checksum="F1DFA85066BFD914" modified="2012-03-21" version="1">MWNDEDNNPYAEGFDRRDSLTSSSANPASPTTREYQRFDIPQTPSTTSDEAPQNRPHDDSEVESSDNEPIARDRGDIVPLPKPGGYESRVEQILWENPSVTILITDAGKSAESGGKYIVYTIRTGNLEVRRRYSEFASLREALTRLHPTLIIPPIPEKHTMADYAASPTNAKQDQQIIDLRKRMLAVFLNRCRRMDEVRSDGVWWRFLDPNASWSEVLHSHPVASIPKSVLKAPPLDPANPTPAHNFLPVPATSAKLKTTGGPGVDPGAISGTGPHVFGRFPPDSHTLSEQELDPYFITYEASIKELEQLLSGSMEKVNRRTLSHLSALAADLCELGSKFNAFALSEQAPSLGPALERVGQAADSSYIATEELSGSLGASFAEPMRENAQFAGVVRSVLKYRVLKRVQQEQTSDELSKKIALLDQLERSEAEAKRIEQYLSSSQQIAPAPKRSTSLREANSSHHQREGSAEDTASIDSDFPPTHGEPVPTASQGVPQRSNSTPGHKKAASSNSITNKIFGPIRHAIQGVADVDPERTRRDMIGKTRESIEQLEQAKVVSEHDVKEASASILKDLKRFQSEKEEDLRRYMLAYAKSQIEWAKKNKETWEDAKAEVSKIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVN6</accession>
    <name>H1VVN6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HK97 family phage prohead protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_03294</name>
        <name evidence="5" type="ORF">CH63R_11537</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006789">
        <property type="protein sequence ID" value="CCF44296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153352.1">
        <property type="nucleotide sequence ID" value="XM_018306511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVN6"/>
    <dbReference type="STRING" id="759273.H1VVN6"/>
    <dbReference type="GeneID" id="28870618"/>
    <dbReference type="KEGG" id="chig:CH63R_11537"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11537"/>
    <dbReference type="eggNOG" id="ENOG502QSR6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022256_0_0_1"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF44296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="493" mass="54501" checksum="613B7E6DC5B6734E" modified="2012-03-21" version="1">MTSVPIRNSPNGENGVKPEGKKQILLNAFDMSTVGHLSPGQWKNPADKSATKRDLNYWIDLAKLLERGGINALFLADTYGGYDTYEGSLDNCIRRAAQWPMTDPTIPISAMAAVTKNLSFAITASTSFEPPFLLAKRFSTLDHFTRGRIGWNIVTSWKKAAFKAIGLDSPIPHDERYAQADEYLRVLYKLWEGSWADDAITPDPENDSYADPDKIRTIHHHGKFFDLDTRHIVDPSPQRTPFLFQAGTSAAGSEFAATHAEGIFVSSHSPQLLRPKIRQIRDKAAALGRDPQSLKFFATFTPIVGRTDEEARAKHEELKKYASVIGGLVLVSGWTGIDLSKIPVDQEVTAADSLEAHKVRSILDSFTTTSEHVPKWTPRVIAERAAIGGLGPVSVGSPETVADDLEYWIREGDLDGFNLGYVTTPGTFEDVVELLIPELRRRGIYPEAPAEDVQLTAREKVYGEGQRGLRADHPGSTYKYDVYKEDAKGEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVT1</accession>
    <name>H1VVT1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nefa-interacting nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_13774</name>
        <name evidence="6" type="ORF">CH63R_00217</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02006831">
        <property type="protein sequence ID" value="CCF44342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163554.1">
        <property type="nucleotide sequence ID" value="XM_018295192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVT1"/>
    <dbReference type="STRING" id="759273.H1VVT1"/>
    <dbReference type="GeneID" id="28859299"/>
    <dbReference type="KEGG" id="chig:CH63R_00217"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00217"/>
    <dbReference type="eggNOG" id="KOG4036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067596_1_0_1"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF44342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="278" mass="29104" checksum="61DCCC8DBD287997" modified="2012-03-21" version="1">MSRFVSAGAINAETGEVVVAEETKKGDDGVGGAAAAAASAVEPRKNAEWEIVQRELEAERKRREEARLKSVEGGERSLYDVLQANKAAKQAAFEEANKIKNQFRALDDDEIDFLDEVRAAKRAEEERVRRETEEGLAAFRRAQGGGVNLKRPGGGDVGDGDGGQGGTGASAVAAAAVDSGAGGEGDGVGGEEEWAVGPRKRRRRERERGFGVKRGRSGDGVEGVNTTTTTTTEEKGADGEKAQSSGEEKSGVVKANPSPPPTKGKLSLVAYGSDSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVZ2</accession>
    <name>H1VVZ2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03324</name>
        <name evidence="4" type="ORF">CH63R_04416</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006878">
        <property type="protein sequence ID" value="CCF44403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160637.1">
        <property type="nucleotide sequence ID" value="XM_018299391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVZ2"/>
    <dbReference type="STRING" id="759273.H1VVZ2"/>
    <dbReference type="GeneID" id="28863498"/>
    <dbReference type="KEGG" id="chig:CH63R_04416"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04416"/>
    <dbReference type="eggNOG" id="ENOG502SCWV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115053_0_1_1"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF44403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16117" checksum="7C623DAC6054B49F" modified="2012-03-21" version="1">MTTQNSSAEETPTSTPRATSLKSHELLTCTIKTPAFSYAHLELITDSPQAPEATADLDNLQVRSYCDAALRQFLGVTGSAIPIDILKVDRTQCWLRVPRPDLSLFAAAITAWAGVSEQGTRRMLRVKQCSDYLGAMVGADGQDKLWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYS1</accession>
    <name>H1VYS1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase p and RNase mrp subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_14483</name>
        <name evidence="3" type="ORF">CH63R_02817</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007698">
        <property type="protein sequence ID" value="CCF45383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162608.1">
        <property type="nucleotide sequence ID" value="XM_018297792.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VYS1"/>
    <dbReference type="STRING" id="759273.H1VYS1"/>
    <dbReference type="GeneID" id="28861899"/>
    <dbReference type="KEGG" id="chig:CH63R_02817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02817"/>
    <dbReference type="eggNOG" id="ENOG502S6UT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047273_2_0_1"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="244" mass="26337" checksum="9B95C11C05921C13" modified="2012-03-21" version="1">MATQLRKKLVYSVDSPFSATHWPDITPEDQDAILELLLSLLSPLGQYRQRHIKPSEGKRTSKRKRTAPGAASTEPVKSERPPAPELASFIDVGLVAITRNLEKLAAGQQGFEGTSKHDNAAANSPSPYSIIFVARSGQPSAFNCQLPQMVAVASKSSPSEPPTRLVGYSRPCAEKLSACLGIPRASAVGIRVGAPMSKALVDYVQQHVSPVRVAWLDEAEKAVYRPTQLKIDEKMVPAKKSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZ07</accession>
    <name>H1VZ07_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_03615</name>
        <name evidence="6" type="ORF">CH63R_07478</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007778">
        <property type="protein sequence ID" value="CCF45469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157231.1">
        <property type="nucleotide sequence ID" value="XM_018302453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ07"/>
    <dbReference type="STRING" id="759273.H1VZ07"/>
    <dbReference type="GeneID" id="28866560"/>
    <dbReference type="KEGG" id="chig:CH63R_07478"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07478"/>
    <dbReference type="eggNOG" id="ENOG502S4E9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011385_1_0_1"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="3">
        <location>
            <begin position="73"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="2">
        <location>
            <begin position="190"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="347"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF45469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZK7</accession>
    <name>H1VZK7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_03673</name>
        <name evidence="8" type="ORF">CH63R_04896</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007956">
        <property type="protein sequence ID" value="CCF45669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161117.1">
        <property type="nucleotide sequence ID" value="XM_018299871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZK7"/>
    <dbReference type="STRING" id="759273.H1VZK7"/>
    <dbReference type="GeneID" id="28863978"/>
    <dbReference type="KEGG" id="chig:CH63R_04896"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04896"/>
    <dbReference type="eggNOG" id="KOG1262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_1_2_1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497781" evidence="5">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF45669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="518" mass="54415" checksum="548B2693222CC0DB" modified="2012-03-21" version="1">MVRVSLILAQLLAVVAAPVAAAAEVLADASAASAVAPSLVGSENTVCGLLRLKYPKQTFLAGSDGYAYETQTQYWSARAYATPACVFVPQNAQQVSFAVTTLTLSLTKFAVRGGGHMPVVGYNSIGSSGVLLSTSNLTTLALSGDKSTVSVGAGLRWRDVYSYLSPSGLAAVGGRIGGVGVSGLLLGGGISFYSNQYGFAADNVVRYQAVLASGIVVEATATNAYADLFWALKGGGNSFAIVTRFDLKTVKSSKVWVGISQYAQTDSAKYLDAVYNFGKHGSADGKAAIIPTILTYPSYNITAYAAARFYDSETQPATAFENFTSPVLAPVADSYALQPLAEYISAVDALQPTGLRQEFRVLSLVVDRDAIDYVHDAFLAATGSKLTGIAGLSASITFQPITKEFIQQGVAKGGNPQGVDPARAPYFWVVENLTWQEAKDDAAASGFADTVTAEIEAGLVSRGVAGGYLYLNDAGKGQKIFQSYPAANLARLKAIRAKYDPLRIYTNLLTGGWKVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1W0S5</accession>
    <name>H1W0S5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_03779</name>
        <name evidence="12" type="ORF">CH63R_06640</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF46088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159465.1">
        <property type="nucleotide sequence ID" value="XM_018301615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W0S5"/>
    <dbReference type="STRING" id="759273.H1W0S5"/>
    <dbReference type="GeneID" id="28865722"/>
    <dbReference type="KEGG" id="chig:CH63R_06640"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06640"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_1_1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF46088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="463" mass="49964" checksum="312DFA49A9C1A500" modified="2012-03-21" version="1">MATETPNTAPPPAATSIPDDKKTQQPQKKEDKAQKKDAAATSEGGEKKLSGAELKAKAKAEKAARRAKAKEAQPAPPPSQGSSQQGGAGDGKGGKAKPRQDGPQGSGQAGGPRGGPAAKAVPLATPKDNKPKVPECFSHLSIAKRLHMTEADKDVHPAVLVLGQQMGAFAINDSTTRLEATLLAFKKVIDSYTTPPGNTFSRHFTSHVLNPQIEYLSACRPMCFSMGNAVRWLKLQVSKIDIDLPDFEAKKLLSESVDNFIRERITLADFVIVKTAADSIEEGEVVLTYAYHPLVERALRQARADGKRFSVVVVDDPFENTGRDLAKRLRDLPGRDGGLEVAYCPDLSAMRDHLRETSRVLVGAEAMFSNGAMYARAGTSDIAIAAADQGVRVVALSETINFTERVAMDSLTYNEIDPEQNTEEGFRLLFDTTRDRHISVVVTELGITSPVSVPAILRKLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4K3</accession>
    <name>H1W4K3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SIT4 phosphatase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_15815</name>
        <name evidence="3" type="ORF">CH63R_12353</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009689">
        <property type="protein sequence ID" value="CCF47416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151744.1">
        <property type="nucleotide sequence ID" value="XM_018307327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4K3"/>
    <dbReference type="STRING" id="759273.H1W4K3"/>
    <dbReference type="GeneID" id="28871434"/>
    <dbReference type="KEGG" id="chig:CH63R_12353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12353"/>
    <dbReference type="eggNOG" id="ENOG502RR4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326286_0_0_1"/>
    <dbReference type="OrthoDB" id="5242320at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF47416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="224" mass="23692" checksum="2729A5F57E0CEB2A" modified="2012-03-21" version="1">MHQKKNAAAAASRDEGGEGEGAKGDREESGGGETLKNPFADDEDDEENSSDEDNDDHGGTGAAAATTVTSAWSQSGQRSWWRGAGRQGRNPRFDGQNDSDDEGDEEEDDDDEEFGDFAMPEVEAAPGTDLNDKSILKPLAVHPSQGGSGGKAFSGLWPFAGKKDGRDERTQSDADKGSSADETATGDDEKPIQAAIEAARRTSIEDPDDDDNDDEVVVQKPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS49</accession>
    <name>A0A1B7XS49_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151120.1">
        <property type="nucleotide sequence ID" value="XM_018308802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28872909"/>
    <dbReference type="KEGG" id="chig:CH63R_13828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13828"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1507"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1647"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1812" mass="198714" checksum="CB84FB3CB5E78B8D" modified="2016-11-02" version="1">MEAGGRGLRQALAEAQEKTQAAYLLMSDPGSHSEVRLALRLISGTLHSLLLLFDDFADEEYDAASTRPDHTLIDSLGDTLDDLIEAWLRGFVAPGRGTEMPSPPEFTSQIRQFHAQLSPAIHANSWAALLVFLSTTGSRKPSRKRETDELNGTTCGASETSPERCLNLLLSPEFDRKLDSCYCHRVYAAERDATHPEYVVCAKLLPEIAHYYHRSVENELRLLFHPRKSANFLQWLLEYARQEWPGHFNPASGALSMSPLRQLMSAVSDASVSTLHIASALGLHHVCEALIHLEKQDVNQQSLMGTPLYCALLGPTALFARYDDPTQLVADRRPTSGQEPTLHVLLDAGATGTSVSTGSQQDEALSLATVAFFTCQSIDAPDAMVRILRSGFSRDDRFIQLFHGKNSILQYWPSPLPPLTRSFLASVLPEILDSAVMQYNGDDETSLLMAGIYDVLEHHGLADTCSGRGSRPLSVSDKVYADLVQEAVQDHKAAVVRRLILDPRWNPNQSIPSCLDSEEPFQKPSTILHDAVESCDVDTASLILQSGDDVDVHVRDECQRTPLMLSETPDVLRLLLSHGARTTDTDEDGRNVWHIAAANSDIGMIDALHAFDEHTDWNLRALMKDGQTPIAQSIIYPLSRTKRLSKSKTAAGALHMLEVCEPNAAYLQSPTPLLFLAVEWGSCELVRKLVDFGADPFEMGDDGRNALHYLEVNAGEDLVEMLLNLHVAPVLTRDGQSPAETIFTAFNDSLFWDPDPDRPNRRPVNHRPLDFGAFNRLLTVEVLGSRNSEGAGLWERFATGVLGTWASKWPPGSNVWESLQTAVDCLIEKVIPVRYEEETGKCALVPVLSAWMGYATTHDKWPVRLGEMLCSILRVSTKVESFQQSPTAVQCLKLAVEQGHRDVVVMLLDLGVSVHAQHESVSALESACLPESTCPPAMFDKLLEHADPKKLNCVDGFRSHFLFRLLDDGVSHRTHKLSALVDKGCDPNALTPAGVPMVVAYINNRETNAAIILLEKGANPALSLPSGLDAALAAASSGDLLVLEKIRSISSTDSHPWGKCCTYDFSRVVGPKVVPEMARQWGCNALHLAAAHGHADVLQFYLGFPDLDVESQTADGWRPLHFAAACAADGGSCVRLLLEHGADPTATLPFPMDQNPLNLASISGATEAVRLLLDVGPGIFSRMNIPAAFVEAFRSGKSDLMEPFLPLMHEVIMASAGNTGQTSVLGAVLELCIQNGYEQLAAEAMTMVRPEIMNSIRMRCGRCSPLVLAAAQGRFTLGEIFLDHGMTAWNLVDRCSHLSVISRRLRYPCPALHIALMRPSHLPSTGTEEGFVRRLLGVMDWTRHELSPFHCAVASGVPDRVRMVVDWIRGSPEHHPRLLHGMQAWGLLPANEDAESGDQDPSWGFSGNGAVDAIIKHHVNKRVASPDLQPTFRLGMTPLLIAAEETNIEGVSSVEMMEVLLGHGAEVNVSDLETSDTPLHGAAMVNCIDSARRLLDHGADPNLYNLNSFTPLTVAVRRGHLEMAQLLVERDADVHVRDIDGMSLLNACACASEHPEMFIWLMSLGLDPCRPEETGYTPLHKVILNNAFPGLIFNHGLDFSRIRDVRKGFLSLVIKSHHRRADGTLRRLFKRLPRENALELANSTPGAFFSPLCVAAVRDRLDCVSTLLRHGADIDAEGSPEGSALMAACSRQKLKAVKLLVRSGASISYQAMVDGVPVFRSALESARPYPHVVRWLLVDRHARLRSIESASEDVGEAEVKPWSGGRVAGYQLSGIGINTGRRVGETGLEYLRRLDRIRWSLRGQTIQVVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT03</accession>
    <name>A0A1B7XT03_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_14103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151395.1">
        <property type="nucleotide sequence ID" value="XM_018309077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT03"/>
    <dbReference type="GeneID" id="28873184"/>
    <dbReference type="KEGG" id="chig:CH63R_14103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14103"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="336"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="726" mass="81112" checksum="32C7BDBAAB10755F" modified="2016-11-02" version="1">MSNPSAVMRTAPIAIAPKPPRRQNSYRQDSFANLELFRGSMPGRDMAESVGSYTTRSLSPCEFCHRSRVKCIVSDDEDSCIPCQASGSDCSLLNSPQPRKRKLNGDFDDSGKRSSPAKTDIRRRKQHQPSLSSTTGSSSFLEDMANVGGPTLLKRTLGLQNDRFSQYIGPTTDFEPSLINLSPFNPQDESLLARGTLRKVSEDDTFLLLPDSNTPGHEHVLEDVEEIENLVRPHGRRLVDLYFRIVHPAFPIIQKTVFLEKYERSYREFSPCLLAAVYLFAINWWEHDEDLARVPRPNIPNLERMIRTTLADAMYRPKLSTIQAGLLLSQRPEGDQWAPTAQLVAIAQELGLHLDCTHWKIPPWEKGLRKRLAWALYMQDKWGSLVHGRPSHIFSSNWGVQPLTQHDFPDVEWDENDVEEKLEIERGRTLFSQMVQLSQILAEILDTFYSLQAMQTVTNAGGQGTHLVLGMAKPIQLKLKEWYASLPAAIRMDNTYSTNPTPANRLSSIGYLHLAYFAAEITLHRRIIRSLEATGSAVDPYVQHICRSAAKARLISAMDFVNRLNSFHLRSFWYFASKTNFALIGTFGSLLWATSPGREEADWYRRRLGEYRWTLSVSSKPGEGKGLTEFAMTMLDISTGLLKKLPEKPSMSRSGSVVDIGPGSMSSSFAGNSLLALGQSAPPTMTLGGFSGFQSADVSNAQSPISDDSSDDEMYETFAPTAGMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTL4</accession>
    <name>A0A1B7XTL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-grasp superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_14328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151620.1">
        <property type="nucleotide sequence ID" value="XM_018309302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTL4"/>
    <dbReference type="GeneID" id="28873409"/>
    <dbReference type="KEGG" id="chig:CH63R_14328"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14328"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13535">
        <property type="entry name" value="ATP-grasp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="289"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="641" mass="69731" checksum="6BA0C35EECF9ADF5" modified="2016-11-02" version="1">MTVDRQSWKTERLPKETGTLVVNVYPDNTLREHADGSDTDAASSSAAVRNFLLDGTREDHSLVKLLLPMRSGYVVQSDFLERRMVDCLNVTEVRGFVAPGQHIQGLSADAYESMGLSDLLPYSYGAVVMAPSCAAGVEKSAALLDEELTKRLSFAWLSPNPIPHRRLAFVGAAPLSKFKGYAAAAAALNIALVVLDVPDQVVARDEYAHLREEFVPVDLTADAGLAQRLADVVSEMQGTGKRFDGIMSVDEHLLGIVSQAATLLGFPTSPPAAIALAQNKFQTRQLDANAYARLVRSPADLEALLAEEDSGRAPPPYPLIVKPCKGWSSEGVWKVDNERELRARVPMLWQDLFADWHGRDVVVEAYVDGPEVDANMALVDGEVAFFEVNDDFPSSADNDDDGRTRDKSPPATFVETSNMLPSALAASELEALRRRLHEIALAVGFRDGVLHMEARLRNSSSHYAREEGGGSLVDLRPKAGATSSAKPEDVFLIEINPRPPGWQEVEATAHAYGVSYYSLAVLNAVGDRDRFAALSRPFVGGAQYHMQLLFVSAQKGGTYRSGDVCAAVLDHGGAAGRRLREHVVECATLMQDGQEVPDPRTGKVFGSFIAFFLVVSRTSRREAISIGREIEQLVRGHTDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU00</accession>
    <name>A0A1B7XU00_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinate-nucleotide diphosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151722.1">
        <property type="nucleotide sequence ID" value="XM_018307305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU00"/>
    <dbReference type="GeneID" id="28871412"/>
    <dbReference type="KEGG" id="chig:CH63R_12331"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12331"/>
    <dbReference type="OrthoDB" id="4161727at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="832" mass="91034" checksum="FD9CA380A15A5189" modified="2016-11-02" version="1">MQIPHGEMSPTPPEKEKPPVTGDIDPPHEDGRHCDVSSGASDVETASRHESADDARQEEDSFELIQTESPRDRPGVRGRLSRFLGRPLLRRQEGNTDNKPPMKESPSPVPSQAGSQHHAQQPSADLHPGPGVPGVSWPADQSLDTKAKRKEQHHPKPSNGSESGTLWPEFLSETSVKSGADDMSESLNQPGEHSPSPPTTLRRAVSTPRSGEGTNGSSSGAEDEAAQEAEDPSRRVQRLMVDKVMSSFMNWLDTKLKVKDEGGSQEPEALLRQVPAWPSTSGYESRLLAAGPVGRAGGPPELGSAPLFSATSEIDFMSDDSSTPARRISLRSKPALSSTPPPPPPPPSLPVSRAQNSIPDQQKTGKAVLLFSRGRSSPKPEPLKAAPPSRSSVPPANYHLGAPLGRSSASQVVPAAAVAAVAAPAPTPQSKRLEASSSKRRTARKGAQVVGPSSQTRGKRPGKHDRSTDGKNEGNDEEDDDGDDDDDEENFSPRAKLPKIHEDGGNRAKLACPFFKHNPRKYKNQRPCCGPGWDHVHRIKEHIYRKHSLPRFSCPRCCQPFETQADLQAHARSADACEVREPEALDGITQDQEKRLRSRKKTSAKELTEADKWTQVYGILFPDGREREIPSPYYNTEDAETNLGGYEDYLRRELPPLVRRQLEAEVERELSFVEEGMKQKVIDIARNLQLALFKGYQQLENQERHHLGPQCVEASASQTDRSTTSPTNDTSPSTMTTSDTTPEIPDPLDIFNADAIPDFEFDFLSEVPFPEEKEPSLDFGFTQSFDAQQPATIQPGMELLSGQQFSLPQYGLEDYQDNRGHVRGAGALGYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUE3</accession>
    <name>A0A1B7XUE3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151894.1">
        <property type="nucleotide sequence ID" value="XM_018307477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUE3"/>
    <dbReference type="GeneID" id="28871584"/>
    <dbReference type="KEGG" id="chig:CH63R_12503"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12503"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="299" mass="31812" checksum="7AD0A8EEF31F2C39" modified="2016-11-02" version="1">MRVTQPEVPVARDSEAAKQAGRRLFFNEVPETPSKASRRGRRPQRRVLNAEIKIIPSLIWGPSSTSSNSTEETRDTEAKLRNTLLGQPTYTDWGFWARPSGGGERAITATGHGRAGQGRQGSRADQEEKGSSGLTREFVLQVIGTLPQHRERPTLEPSWGWLSTSSWMPIPLASEGCPAGNQQQGKRRGVGGKATNPTKGFGLVSRGQQGYVGVLATEVWITTMVDGGSKPSFGGTGELPLVLVVINQQATPAEDGAISSLFSNMPFSIFPLGAGAAGAGAGLEPSRDAAGLERPGKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV36</accession>
    <name>A0A1B7XV36_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone chaperone domain CHZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152118.1">
        <property type="nucleotide sequence ID" value="XM_018307701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV36"/>
    <dbReference type="GeneID" id="28871808"/>
    <dbReference type="KEGG" id="chig:CH63R_12727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12727"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="113" mass="12423" checksum="9F61814677EB003D" modified="2016-11-02" version="1">MAAENENIAAAVPEETKGKGKAVAAEEPVEKSDAMEEDEESSDEEENTEVAEAVEEEDGMEEIDLNNIVEGGRRTRGRVIDFAKAAEENPAEDDEDDEDDDFQAPDDSRMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVH0</accession>
    <name>A0A1B7XVH0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic region leucine zipper</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152274.1">
        <property type="nucleotide sequence ID" value="XM_018307857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVH0"/>
    <dbReference type="GeneID" id="28871964"/>
    <dbReference type="KEGG" id="chig:CH63R_12883"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12883"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="278" mass="30845" checksum="FD253CAAE88D57C9" modified="2016-11-02" version="1">MSPYTSTGGGRAPNVSRYLRDLNTVKEPAAGEENFTFEDDLAIFTNTQFFDFETGQHTDYQASAKKPETVEPQAPSSAVTEELTSPIGDFNVDFSMPGEFNFHDFTNPYPASGVPPFAEGLGNLQPLQPNPQSTYAAPPVSQQQNHHYGAPTPRATETRTPESLNGVSRPGHSFEEQSRVAAEEDKRRRNTAASARFRIKKKQREQALEKSAKEMSDKVSALEQRINLLETENRWLKNLVMEKNEGNEDIASMLKEFQNKQPKSTAASSGSVKAEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVM3</accession>
    <name>A0A1B7XVM3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UBA domain-containing protein Ucp14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152312.1">
        <property type="nucleotide sequence ID" value="XM_018307895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVM3"/>
    <dbReference type="GeneID" id="28872002"/>
    <dbReference type="KEGG" id="chig:CH63R_12921"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12921"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="29826" checksum="D8BEA9BFA17E382A" modified="2016-11-02" version="1">MSFTNAPVTRTLVLGLVTSSIAASLLDVKHYFYIVVDTHLWRYHQIWRLLAYQLCCTNSSEVLFASMTLYHLRVIEQIWGSRKYASFVAVSALFTAVVPPVLLSLVLRPLTAGLFNYMPAGPTPIIFAILAQYHAVIPHIYRYRVAASSAPPTTDEFVGLTFSDKSYRYALALQLALFQWPGSLLGAAIGWVVGYSWRNDLLPGALTKWRLPGWMVGVRTQRRRGEFEGLRRRLEGEGSSATTSGAQGQADGDAGRRRPTEQGRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVV2</accession>
    <name>A0A1B7XVV2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_13000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152391.1">
        <property type="nucleotide sequence ID" value="XM_018307974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVV2"/>
    <dbReference type="GeneID" id="28872081"/>
    <dbReference type="KEGG" id="chig:CH63R_13000"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13000"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="462" mass="52433" checksum="DF086112D4FBC6F5" modified="2016-11-02" version="1">MNTPEEKVNLDKGDLDLLSIIERTCSVFSLLGCVFIIVTFCSSRAFHKPINRLVFFASFGNMMTNVGTLMARSYIGSPDSAGCQLQAFLVQMFMPADAFWTLTMAINVYLTFYYKFDAERLRRMEIPYLIFCYGIPFIPALVYVFIRNGDGQRVYGNATLWCWVTPEWEIWRILTFYGPAFNLLCEATITNVLRIAILITFFIYIRAGREIYQKRKQLRNFSSSDHDQGNSFHDVLTSVKTTEVYVTSEVVIDQPHGSIGLGPMGRRGSEAGPSPRMPNAAAYSVSISASHNHNRNESLADEVLPVESTAAEAATQRPINSARRRNFELNNAAWSYTKCSILFFTVILITWVPSSANRVYSVIHTRESSTPLEFMSAFVLPLQGFWNALIYVVTSWKACKTLWTDIKYASRRPDVTEIVGTFRHSDSFRIASQNRRTKNYESESIAELTNSRPSSKEQVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVY1</accession>
    <name>A0A1B7XVY1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_13031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152422.1">
        <property type="nucleotide sequence ID" value="XM_018308005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVY1"/>
    <dbReference type="GeneID" id="28872112"/>
    <dbReference type="KEGG" id="chig:CH63R_13031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13031"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="446" mass="48672" checksum="F9A98985FDBEC32E" modified="2016-11-02" version="1">MPPRLEPLRLLRHTRRLPCRLYSSSRSIREHDVVILRQRGNKDPKFHLSPPLRPDAPIKLAYGAKVNASEIIGKSFTDLIHDSDGRDVRLTEASLAQYIANSPRVATPIYPQDANLIVSFLDLNLPVPGEDPDFDADPPVEIFEAGTGMGALTLCLAKAIHGANPPVPPQLRDALCAAPYERNTLPRKLANSDEAPEYNTSPHALDFAGQPELAALHEKHTAGRRAILHTLDINPTSSRMAHSLVRHFRRAMYLLDVDFHVRTIRSYLSSRLSRNGGQPFLSHVILDLPASQEHADVAVEALRPGGKLVVFFPSITQILNFVVWAKDEAQPLILDRVVELQTSTSGGDGMFRDGTGGRNWEVKVVNIRKAVQEGETGAAAQAHVCRPKVGTLVVGGGFVAVFGRIQRQGGPVVEPAEETMATTESASGFVSDTEMCSDEDASARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW45</accession>
    <name>A0A1B7XW45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152481.1">
        <property type="nucleotide sequence ID" value="XM_018308064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW45"/>
    <dbReference type="GeneID" id="28872171"/>
    <dbReference type="KEGG" id="chig:CH63R_13090"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13090"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32411" checksum="D223E9AAEEC3F349" modified="2016-11-02" version="1">MSDSTRPLDSDLIRPGRRPRRERKANGRADGPVLVAAPLAGRSIQRPRRQLRRLLYEVQMVLIALMTPICIRTAQSLLLQIPDGPVRLWGLVKTPLVGHGTWQAQPTCIRTIDTATSRARYIVALHPYPPSPYPRPPRAICLLRRKSMCRPCRSSPEAFPASPLDLSRLSLSRVSDTQLNVLVQVPRRCLPDNDGSLRSSLHKHASPPQTTPDADRVPGVLTRCSKPPQSRRMCSALLGHGQRGSNRKERPLPPRVCGSTEKGTDECAVDASGTDLSDGCADSHDNGGTGGCDGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWD4</accession>
    <name>A0A1B7XWD4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152573.1">
        <property type="nucleotide sequence ID" value="XM_018308156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWD4"/>
    <dbReference type="GeneID" id="28872263"/>
    <dbReference type="KEGG" id="chig:CH63R_13182"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13182"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="323" mass="35325" checksum="088F15032D20C40B" modified="2016-11-02" version="1">MASPTTPFRAVYKTIGQQEIDVDIYLPPPGSPDKSSHPVVINIHGGAFMLGSSKMVNRDQVADCLDRGWIVLAPNHRLCPQVSLLDGPMRDCRDLLEWVYSGQLQRVLDTTQGGSHTVDNDHVFAFGTSSGGTLALSLGFGVPRPVAGIFDMYGPSNFTHPFWEKPLPHVAARLPPGLTQDFLNKVFDEDPVPIEGGVSLEGQAQGPPNFDDPRQAFAMTQIASGNVMKAIVPDGNWDAVDPLRNITASFPPTFIVHGQADTMVPLELSQGLFQALREKGVRSGLREIPGEEHTFAARMKVGSQTWNLQREGFEFLESLIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWF5</accession>
    <name>A0A1B7XWF5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152615.1">
        <property type="nucleotide sequence ID" value="XM_018308198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWF5"/>
    <dbReference type="GeneID" id="28872305"/>
    <dbReference type="KEGG" id="chig:CH63R_13224"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13224"/>
    <dbReference type="OrthoDB" id="3873024at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601134" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="12752" checksum="D588433A4A27621A" modified="2016-11-02" version="1">MRFSTSALASAVFFAFFADARYHDSCTCHNGGTYNWRLTTKACDSERALLAQQKSWGSVQYDTPSGRCRSVGVTDLISGDDFETLCKAVASQVGFPCAFDNSLTCYADPDAVSSWCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXS7</accession>
    <name>A0A1B7XXS7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153059.1">
        <property type="nucleotide sequence ID" value="XM_018306218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXS7"/>
    <dbReference type="GeneID" id="28870325"/>
    <dbReference type="KEGG" id="chig:CH63R_11244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11244"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR04541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6906" checksum="002B867CE86B0204" modified="2016-11-02" version="1">MCRRDPAGLDVRHAALNTAVGQEHPGIMVELIAELDSDWQELLSLWAVEEERLLFDRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXU0</accession>
    <name>A0A1B7XXU0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Archaeal flagellin n-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153072.1">
        <property type="nucleotide sequence ID" value="XM_018306231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXU0"/>
    <dbReference type="GeneID" id="28870338"/>
    <dbReference type="KEGG" id="chig:CH63R_11257"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11257"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="274" mass="30818" checksum="E90755CD959D9554" modified="2016-11-02" version="1">MIGARVYLRLIIQDLPLNASDILVCAAWATSVISASFDIVFHKLGALRPYVSYNLDGYRGTPEEVEFIWKLQWGGQFPFFTAFYLCKATLLTLYARFFPVFMQTRRKILWGTMAFCGCAYLATILTTLTICRPIEGNWSSDPAVACSPIVFAQVFYVGWALNFAGDLMKLWSILDLQTGLVIACIPPLRPYLSHTWTMWPFRLANRTPKESGNRSELSEVPQHHDQSRPRREQPSNMSSAENLYDLESQGVGESHLDAESSAMASPKSPVSTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXV7</accession>
    <name>A0A1B7XXV7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fusicoccadiene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153114.1">
        <property type="nucleotide sequence ID" value="XM_018306273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXV7"/>
    <dbReference type="GeneID" id="28870380"/>
    <dbReference type="KEGG" id="chig:CH63R_11299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11299"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="715" mass="81388" checksum="FBF31B2887297CAE" modified="2016-11-02" version="1">MLSYSTVVDPVTYETEGLCDGIEVRISSFTDLEDRGAIRAHHDWNKYVEPCREYRGTLGPKYSFMSLTVPECLPDRLEVISYANEFAFLHDDVTDQVDFERGEVENNEMMNAFLEAAHTGSIDSSASEAARAGKKRIQSQLFLEMLSIDPECAKTTMKAWARFVEVGSSRKHETRFQTLDEYLPYRIMDVGEMFWYGVVTFGLSLRIPDHEMDLCRKLMAPAWIAVGLQNDLWSWPKERDAAEKQGKDHVINAIWVLMHEHKTNLEGAEQICRRLIKENVAKYLQIVKECRDDASLSEDLRKYIEAMKYSISGNVVWSLTCPRYNPQVPFNERQLRWMHEGVPELETSCSSPEAESVSSSSPVFSETHSKDGADLGDKVILERISSQSSFSTPPEMDDNEYQVKVGPQLAYEKEILEAPYKYIASLPSKGVRDRFIDALNNWLRVPHDTLEKILVVTRLLHNASLIMDDFQDDSPLRRGKVAAHTIFGPAQAINASTYTIVKAINQVAEFRSQSCVHETTACKSEKIMALFQGQAMDLFWTYNSRCPTMNEYYRMVDNKTGQLFSIVTRLMLDNHECISTKTSAALDKFTTLLGRYFQVRDDYQNLASADYTKQKGFCEDLDEGKYSVPLIYTLQTQPDNIQLISLLSTGKKTGTLTREQKECILEILEKSGGLAYTRVVLLRLHDQASAALKKLELSFGSSNPEMKVLLELLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY83</accession>
    <name>A0A1B7XY83_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153255.1">
        <property type="nucleotide sequence ID" value="XM_018306414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY83"/>
    <dbReference type="GeneID" id="28870521"/>
    <dbReference type="KEGG" id="chig:CH63R_11440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11440"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="20260" checksum="10A1CB6D0793626D" modified="2016-11-02" version="1">MLTHSNRSPYFKGPWYSVLYPMYSLQPVRDKEENAQRRGAWDRGFSSKALRDYEFLVADYTNQLLSQTDAHKGESSILTVLTDWFNFYSFDVMGDPSFGKSFGVLKESIKYCFMASLHQHMQSIGMFSHVLWLFPILRNTPVLNANNKRFRRVVKSRVDERIKNPPSRPDIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ32</accession>
    <name>A0A1B7XZ32_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153528.1">
        <property type="nucleotide sequence ID" value="XM_018306687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ32"/>
    <dbReference type="GeneID" id="28870794"/>
    <dbReference type="KEGG" id="chig:CH63R_11713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11713"/>
    <dbReference type="OrthoDB" id="5405791at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056929">
        <property type="entry name" value="Znf_RING-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25080">
        <property type="entry name" value="zf_RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING zinc finger-like" evidence="2">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="461" mass="50816" checksum="2817F3254C68B25B" modified="2016-11-02" version="1">MPPRSSLTSSFSITDSNNEVVCPLRNQDGSSCRKRCIGEKRYRSMQEHIRRAHPEHYISKLPATEESFLLMINTPPSERPPMQQPNATSVPQGSSLSIQGFSSKIDHPQGFNHDRHMYDNSNPGTPRVLEDHTVSSLLPTASAAAALAQLHGHKVEPEWESEMGWHSDSEGRRIPRTSIELPPLHLSNNDITSEPFPAMNSSRPRDILPSILTNSPPGRSSTLPPIQRPVGPARPRKQSVTKRGREAHHKKQKSRGSAADWLRRIQNDERLRPGNNDRKALSAEPSADYGKRWEDLIDAADQAASAAGDIDEDRTPMPQSPVSIHRASLPPFQHHHGFQAAAGGNYQASPLQQALTPPSYSQDTIDPFPSVESGESGENFHIESRGLSDSSPSYSSQNTQIYCAACQSVSLLKDSYACTECICGLCQACVDVLMAEQGARRKCPRCATIGGRFKPFQLDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ95</accession>
    <name>A0A1B7XZ95_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional activator of proteases prtT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Zn(2)-C6 zinc finger-containing protein prtT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_11775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prtT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153590.1">
        <property type="nucleotide sequence ID" value="XM_018306749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ95"/>
    <dbReference type="GeneID" id="28870856"/>
    <dbReference type="KEGG" id="chig:CH63R_11775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11775"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="660"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="722" mass="79628" checksum="94205E8C678E3098" modified="2016-11-02" version="1">MPHEADSPAVRRRRLSNESRRSGPGKEDLSRKRKRRILSCDTCRRQKCRCELDEESETCARCRSLRITCTWNDSGDTHSASSRETPSKPDIEGRFRSLEASIVDLKATIQMLASGSRPDVRRTLATDRQERPHQPRPHPAHADQDSNEGCDASKAPGKEDVEPADRHVYSSPAEVVRKVGNQLSGGYRRTFDVQADVVSLGLLDDKTARDLVAEFVRRRRNTLLINSEVDLAPKNRDLRHASPFLHDVCCLHAMRFSEHSSSVLHRRVFEHVRLQMGQLMVASPLPLEELMGILIMSLWASAPSDFGAVSAGWADTTVAGSRIHRQLVGQRALRTASNAEHQFLGNTIENQIQDVDGRGSEGHEALVQYLPEKPPNKLRSYLHWAATTSRPATVPAAYLQQCKLLLNFEEVTMRDAMVYAEIMLYLLLQDKFSQRLYLSGDGTCEELSAWKTRWNYLFELPAASTLRISYSIAWLILARRSLEHDQAAPDHDSLSSSPRLHPVDAAANNGAHSQPSSQGPPDVTQFRVSAFATDVVRAFVDMPTSRAEELPEFHRLCVAYAMLIISKYEQKPSLTMGGSPSGQDDVVLQLLRDAQKHNGVKGNSAPSAIQFGLERALKKVSSRVEGRSSRAGADVGSEALGGNNGSLGAELSLSGAAVAAGPTWAQTTQDQQGDTPGQQHEHPSSHFTGATLVPEFDGSLSLETMDFFFSGGHLGLGDQSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZQ1</accession>
    <name>A0A1B7XZQ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153761.1">
        <property type="nucleotide sequence ID" value="XM_018306920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZQ1"/>
    <dbReference type="GeneID" id="28871027"/>
    <dbReference type="KEGG" id="chig:CH63R_11946"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11946"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="73"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="481" mass="51775" checksum="266DC1A3468833D5" modified="2016-11-02" version="1">MSTPPDQARDAEKRHATQMTDTPVRSGSDLEKSGSSPSVLQPSSSDDNRSRVAQDKDTGRDPDAGDGPDVNADAVTIVGQALSRATSRSSITPAPPPDGGVTAWMAINSFGVFQSYYTTLLFRPPSDIAWIGSFEVFLLFFISTFSGRLTDAGYFRTLFAAGFLLVSLGMLATSFCTQYWQFFLAQGICLGIGNGCLFCPALSTASTYFDKRRGLALGFVSIGSSTGGLIYPTMVRQLLPSIGFGWTIRAIAFVQMGTLMIAFVFLRPRVKPRKAGSIVEWAAFKELEYTFYAIGSLLNYLGVFFAFYYLASYTRDIIGLSYNPSLNLLLVLNGVGVPGRILPGYIADRVGSINTLIPMSFISGLLMYCWVAVSSTSGLYTWTPFYGLAASAIQSLFPSALSQLTSDPRKQGTRMGMTFTIVSFAVLTGPPIAGAIISAEGGRYVGAQVYAGTCLLAGMCFWIAARVVKTRKAGGGLWFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y169</accession>
    <name>A0A1B7Y169_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154265.1">
        <property type="nucleotide sequence ID" value="XM_018304841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y169"/>
    <dbReference type="GeneID" id="28868948"/>
    <dbReference type="KEGG" id="chig:CH63R_09867"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09867"/>
    <dbReference type="OrthoDB" id="4823714at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="405" mass="43617" checksum="AD24FE4038F22B22" modified="2016-11-02" version="1">MAGDARRKGGVYSTNPNTVRTRQSLNSLPPKTKELRRTTFLEYRSLRTCCITRSKKSDYIRSQSRDEKLAMLREACRSTLANRQKKGTELMGTDVDEFTARFHDKALLAQGGSPNSDPVPDESDTNDSDGTEISSANDQDFDPNTLTGLQMANNAQMAQVTTAPSPLGFNIANRVQMAQATDAPGPAGFADFAGNNNDLGLNEQAVMTYNGVVASDPAVQFGQADFANYQDGSLYPAPAARPSPAGFAINHDGGVYSAPADNQFGPANFANFYDESFNPALATPDDFVNGDESSVYPPPPSAPPSPGFADYRDPGIMAVEQEPTKRHQETPNGFVAPPSVAIVSTLASYETSFEHRLRHSEILAEVGGPVPTFISRTWTRGPRATNNLSWADNSGREAGLPDHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1K5</accession>
    <name>A0A1B7Y1K5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_10009</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154407.1">
        <property type="nucleotide sequence ID" value="XM_018304983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1K5"/>
    <dbReference type="GeneID" id="28869090"/>
    <dbReference type="KEGG" id="chig:CH63R_10009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10009"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="869"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR05889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="947" mass="105794" checksum="CBC2522E046D15C8" modified="2016-11-02" version="1">MAATKAVRSQSPKLEKPANGANGVNGKAPVKLESSYKSDGVEDNDIFLLPVSDYQIMLGLTFLAAIVRLFRIYQPTSVVFDEVHFGGFASKYIKGKFFMDVHPPLAKMLIALTGWLAGFNGDFDFKEIGKDYLEPGVPYVAMRMFPAVCGILLAPLMFLTLKATGCRTTTALMGSGLIIFENGLLTQARLILLDSPLMVATAFTALSFQSFTNQHEQGPEKAFQLSWWFWLLMTGLGLGTTVSIKWVGLFTIAWVGSLTLIQLWVLLGDTRNVTPRVWAKHFMARAFALVIIPLGFYMAMFAIHFLCLVNPGDGDGFMSSEFQSTLNSKGMQDVAADVAFGSRVSIRHVNTQGGYLHSHPLMYPTGSKQQQITLYPHKDENNLWLLENQTQPLGINGEQINGTQAWNNLPEPVFIKDGDVVRLYHMPTFRRLHSHDVRPPVTEADWQNEVSAYGYEGFEGDANDLFKIEIVKKKSLSSVSKERLRTIETKFRLVHIMTGCVLFSHKVKLPEWASEQQEVTCARGGTLPNSLWYVEYNEHPQLTGDNVEKVNYRNPGFFGKFWELQKVMWKTNAGLVESHAWDSRPSAWPILKRGINFWGRDNRQIYLLGNPIVWWSSTLAVVVYVLFKGIATLRWQRNCNDYSNTTFKRFDYEIGTAVLGWAFHYFPFYLMDRQLFLHHYFPALYFAVMAFCSTFDFATARISLGGIRNNPIVNRVSAVAFLVLTAVVFVLFSPLAYGNPWTKAECNRVKVLSSWDFDCNTFHDNYSQYTPLLTHKSSVSGATPTPAKSEAPAAPIGGQAGQIPIGDALNEQPKEAAISGVPIQNVLSREEKVEYRDQDGNLLDEEQVKALEGKVEFKTKYETRTRVVDASGNEVQIPEGGWPQEQGGNVAPPHPDVQGVDPETKAKAEDSAVPKVAESVQGQKEAEQKKAKPASDGGKEATAQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y299</accession>
    <name>A0A1B7Y299_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tetratricopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_10244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154642.1">
        <property type="nucleotide sequence ID" value="XM_018305218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y299"/>
    <dbReference type="GeneID" id="28869325"/>
    <dbReference type="KEGG" id="chig:CH63R_10244"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10244"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="715"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="898" mass="99682" checksum="D9086E84A2C08E94" modified="2016-11-02" version="1">MANHHPSPTMAMQGQQHGPPGPPPPPGMQQGQNYAPSRQILLMNEAVWMQIGSFAELLGNLEEAMKAYDRALQANPQSVAAMNAISLILRTREEFHKAVDYLQAILKIDNTNGEAWGSLGHCYLMMDDLQQAYAAYQSALVNLRSPREPKLWYGIGILYDRYGSLEHAEEAFSQVMQMQPDFEKANEIYFRLGIIYKQQQKYGQSLECFKYIVNSPPPPLTEEDIWFQIGHVHEQQKDYDSAKAAYQRVLERDPSHAKVLQQLGWLHHQQSSSFQSQERAIEFLEKSVAADQGDAQSWYLLGRCYMSQQKYPKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPFISEVWYDLGTLYESCNNQISDALDAYQRAAELDPQNPHIKARLQLLRNGGANGGQPPSAPQPADVHPQAYQVGPPAPQWGSSAPQSQQQGGQQPPPPPGPGGPGSNGWGRLADINPPPQPPNPYEQRGEPFRGPAPPMPRQPSPRQEQQQQQQQQQQQQQQQQHGGRPPYPESIRRMPSPPSHYSGPPQPPQQPQGAPTSAPRTINPNYSQQSSAQMPPMNAGPNGPPSQPPQFRGTNSPRPGERPMHDNRMPSPKSAYPQHPPPPPPPYSHHPDGPTPGPMEAGAPPPPPPGAIAADPAAQRNEHDRPASVGPKRMREWEEDSSHKRPANDENRARLDDVRPRRPSTPPGPRDQYRRNSSEARRFEDQRRAEDQRRAEDQRRADDMRRGEDQRHANDGYHPSEAAHHPPSHPMPSNHLPPMQSAAAPMQSLLHDGAQNGPGPASGPAPGVKEYPAEERPPIEHTPAPRPPQSNEPERAARKMDVDEDYDDSGEDEKKGAVPTANGSGPAAASGETKTPTSASINGLMGPTPKVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Q2</accession>
    <name>A0A1B7Y2Q2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154794.1">
        <property type="nucleotide sequence ID" value="XM_018305370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Q2"/>
    <dbReference type="GeneID" id="28869477"/>
    <dbReference type="KEGG" id="chig:CH63R_10396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10396"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="229" mass="25448" checksum="3DCC2E60B9BF4004" modified="2016-11-02" version="1">MPLTGVDHTLTEYGAENMTTASFMIFMIVYPATRRECGWRRKMGKKETKYFITSRRAVAHGRRLLRLPKENSEGFLTTPFPLLDLDAPEARQAHTEWKEGGEGGQCWQAAFFPATFPATFPITRYLGSREVVTPRTANWQGRVQKPNTTVTAETLSPVTTYMVMDVVKATACTALLTAHHGSLAGRGPHVASGSLSPVRHGIVLHPSVPSRISSPSSLPQHLWHFTKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Q5</accession>
    <name>A0A1B7Y2Q5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154805.1">
        <property type="nucleotide sequence ID" value="XM_018305381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Q5"/>
    <dbReference type="GeneID" id="28869488"/>
    <dbReference type="KEGG" id="chig:CH63R_10407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10407"/>
    <dbReference type="OrthoDB" id="4850603at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601275" evidence="3">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="155" mass="15493" checksum="379A643BD1B439DF" modified="2016-11-02" version="1">MKSAVIISAIAGFVNFVAAAPPACLLAALGQQPSPAGVENLCDDHMAAMVGNLTSVCNGNDLKPAYDAYASTCAEIGFKVDDLPLTSATVNAPTSTPEPSGSSEPDATPTPSIPTSTGGKPQESKPSAAGAIAPHAFLFTVLGLSATSLVSMVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2W9</accession>
    <name>A0A1B7Y2W9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ketose-bisphosphate aldolase class-ii family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_10466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154864.1">
        <property type="nucleotide sequence ID" value="XM_018305440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2W9"/>
    <dbReference type="GeneID" id="28869547"/>
    <dbReference type="KEGG" id="chig:CH63R_10466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10466"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="333"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="503"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="9">
        <location>
            <begin position="693"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="11">
        <location>
            <begin position="960"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1139" mass="119809" checksum="459954071E7C3FB6" modified="2016-11-02" version="1">MASPDGPQPTRVGFIGLGAMGFGMACNLLKKPSYRVQGHDVYAPSAERFVAQGGSTGESPREVAKTSDILVCMAVNAQQIDDILFNHQKGALQTLPENATVLLCSTVPPTYHETLSSRIAAAGRPDVLIVDSPVSGGTKRAADGTLSIFASGAPEALQRADGILRDMSEKLYIIPGGPGAGSKIKMVNQLLVGTHIAAASEAMGLAAKAGLNTREVYNIITNAAGNSWAFENRVPHMLDGDWTPLSALNIFVKDMGIVVSTARTLQFPVPLASVAEQLYISGAAHGYGAEDDSGLVRVFLPGAQNIVKEQAQAVKLTTQEKLTPSSTPLEISKIGMVGLGAMGQGMAGSLLRAGFAVHGYDVYEPAVDKFVSNGGNASRAASPAEAAKGADILVLMVQNAAQADDVLFGSGHAADALPDGAIVVLSSTVPPSFMRDLESKLTNLGKGISLIDAPVSGGVVRAANGTLTIICSGDDAVLSKINGPLLAMTGTSSNLCHVQGGVGAASSVKLINQLLAGVHIAAAAEAMAFAARLGLDTRRAFEILGSAAAWSWMFENRVPQMLDADWTPHSALAIFVKDLGIVLDEAKRLTYFAPISSAAHTLYLSGASHGWTKESDAGVVRLWELAGLSVSGNAGPKAQETTQEAQEDELEVEAGQEEGLPAQKTIESLPKEYSGDVISSTRKVVDNGEVPVLVVLDDDPTGTQTCHNIDVLTVWDAATLEYEFSLDPTGFFILTNSRALPSAEAKQLILEICQNVKQAAEKCGKAFEIVLRGDSTLRGHLPEEPEAAEEALGKFDAWVITPFFYQGGRYTINDVHYVKEGDVLVPASQTPFAQDATFGYRNSNLRKYVLEKCGSRFDESSFLSVTLDDIRVGGPAGVTKKLLSVAPGSNTVVIVNAAAESDMHVFVAGLLEAEKEGRRYLYRTGAAFVSSRLGITGIPPLTMADLGVSVTAGTKQPGGLIVAGSYVPKTTAQLKVLRERRGDKLTVIELDVAGLIESEEAAEKVVTAAAAETASKLSAGEDVLVMTSRKLIKGGDALSSLQIGSKVARALVQLVEKIDVRPRYLIAKGGITSSDAATKGLKMRRARILGQAAPGVPLWRCDEETSRHRGVPYVVFPGNVGSDSTLAEVVESWSIENVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y468</accession>
    <name>A0A1B7Y468_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_10895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155293.1">
        <property type="nucleotide sequence ID" value="XM_018305869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y468"/>
    <dbReference type="GeneID" id="28869976"/>
    <dbReference type="KEGG" id="chig:CH63R_10895"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10895"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="157" mass="18448" checksum="E4F1CF78E7E2F5BC" modified="2016-11-02" version="1">MLSRRMLTKADEESVGDEVEVRREDQDKINKFSRLHQRELIIEEELRNKSKEKEELDDLSTELELTDEDETVPYDFQARLARRADSAMLTFDDRYKIGDAYFHVLQPQAIEMLEQASAKIEEDVEGLESKLETIKEEMTQLKVELYARFGKSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4B6</accession>
    <name>A0A1B7Y4B6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH63R_10933</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MRN complex composed of two heterodimers RAD50 and MRE11 associated with a single NBS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 19">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155331.1">
        <property type="nucleotide sequence ID" value="XM_018305907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4B6"/>
    <dbReference type="GeneID" id="28870014"/>
    <dbReference type="KEGG" id="chig:CH63R_10933"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10933"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 17 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 17 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 17 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 17 19" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 17 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="21">
        <location>
            <begin position="240"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="464"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="648" mass="73070" checksum="09C5CA527A350B04" modified="2016-11-02" version="1">MVLLGGDLFHDNKPSRKSMYQVMRSLRKNCLGMKPCELEFLSDANEVFEGAFPHVNYEDPDINISIPVFSIHGNHDDPSGEGHFCSLDLLQVAGLVNYFGRIAEADNIEAKPVLLQKGQTKLALFGLSNVRDERMFRTFRDHKVKWFRPGVQQSDWFNLLTVHQNHHAHTATSYLPENVLPDWMDLVVWGHEHECLIDPQQNPETGFHVMQPGSSVATSLVPGEAVPKHVAILNVTGKDFKVEKLPLKTVRPFITKELQLATDPRFKGLHAKKDNRQELTKRLMVVVEEMIQEANEEWYAVQDNDEEEPPLPLIRLKVEYTAPEGGQYDCENPQRFSNRFIGKVANTNDVVYFHRKKAGATRRNADTDVPEMLEETLGLDTVKVEALVQEFLMAQSLKILPTAPFGDAVNQFVNKDDKHAMEEFVSESLAGQVKQMLSLDSDEEDLDNAMEAYRAKLEEQFSKGALKRSTKRTVKPKPDEWDSDLDGHWEDQPGVVETETVSQAPARSRRAQTREEDDLMEMEDEPAVGPAPARKAAATRVTKAAPAKKAPAKKAPAKKAPARGRKKPVFEEESEEEDVVMDNDFEEPPAPTRARRSQPARAPPKSRQTKLNFSQATTSQAAVEISDDEISDEDAFEPPPPTTRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4E1</accession>
    <name>A0A1B7Y4E1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155371.1">
        <property type="nucleotide sequence ID" value="XM_018305947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4E1"/>
    <dbReference type="GeneID" id="28870054"/>
    <dbReference type="KEGG" id="chig:CH63R_10973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10973"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="893" mass="96299" checksum="CC19ABBB9066475A" modified="2016-11-02" version="1">MSWQMVPGMGSNVGNGMGGPGGNEMGGAMQGNGSNQPHATEYTLQGVMRFLQTEWHRHERDRNAWEIDRQEMKARIAALEGQARRSDATQKALKKYVTILEKKVKDQAAQLKGGARAADEPAEAEKNRAFQIQEKLRSSKKSPDAHDNELDIEKGDDESQRADLKSFLDQCQAEFTYLMVTPANPLPPRESPPLPILEDLREGEPFGIAAGKPFQEPPFPFASSSLVPQNHMREANRPPPAPNHAPPMQRSQPTSFQVKPVEQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQQQQHQSMPPQNPEPAPPVMYAAGTEWPQPMSVTARMLDDNLQRPSHAVESVSSVEPTDEPQPSTRPAPESDAWDFSDGAFPESNSSQPLQQQLTNRPDTDAFPTADSLPKSPNRGPGSNRRKGSMSRRRSAEHELSLNSAAQKSETGNFKLRFGLRGHLDTVRTVIFSGGGSPGEPEICTAGDDGMIKRFHIPRVDNHGQTNAASDLDVTANFSHRGHAGAVLCLTSWSPSPSFSTGGRAQGDGWIFSGGQDATIRVWERGRVDPKATLEGHTDAVWALCVLPTTLGAIFGQNSQYGSPDRILLVSGGADGSVRLWAVSAPPQLTSPQPGTNRAGPSGSRGRVRGNSMSSGSAFSSNPQPNMASNSPFNHTLVHNIPRPGGSDASPTCITPLSPSGETFVVSYSDASILVYDTRTGEQTGTMDSSETYDGSINTSVNAVVATTVGLEQPQGGLSEEESSAGGGPTGGGRSMAGSGVEGVIISGHEDRFVRFFDANSGKSWKSGADEQSADQSSGQCTYNMLAHPASISGLSLSPDGRELVSAGHDASLRFWSLEKRSCTQEITSHRIMRGEGVCSVVWSQDGKWVVSGGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Q4</accession>
    <name>A0A1B7Y5Q4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155850.1">
        <property type="nucleotide sequence ID" value="XM_018303827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Q4"/>
    <dbReference type="GeneID" id="28867934"/>
    <dbReference type="KEGG" id="chig:CH63R_08853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08853"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="275" mass="29390" checksum="479F17C9F51E4F98" modified="2016-11-02" version="1">MHRIASRFTLRTVSLTFEPWNFPPRFLAALPCSLGGVVMAQKDIYSAVASLNSSTPGRQKASGSAKKTLIALHLGPGLGLGPLRMSPNVGLSPASLPRLPASCQLIPDAAPLESSVSQFYSQKVFSYFAALRRPSSKVCVPSSGDQSTVASRKADLSCCTEPALDHDLQSAVAHLPRQGLLPTARRDPRDPEASHGLEPWSRVDADPFCRGFVVAASNASIGSESFPETESTGMHAPPLGLPTSRCQIRTSPRGSHADQVIQETHHNLLEIPSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6J3</accession>
    <name>A0A1B7Y6J3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome p450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09152</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156149.1">
        <property type="nucleotide sequence ID" value="XM_018304126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6J3"/>
    <dbReference type="GeneID" id="28868233"/>
    <dbReference type="KEGG" id="chig:CH63R_09152"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09152"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF234">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="501" mass="56878" checksum="9059BA12DD9B3B51" modified="2016-11-02" version="1">MFSYTNHTSLSSEVSAFRLFLARTSVFEVATLFIAISLFWGSFRAIYLLYFHPLASFPGPRRAALSTWWLYSQSKSGRAEEIFEELHKKYNTRALRIAPNEIHITDSALYHTIYSQRHTFTKQAHFYSAFMKPYSVFVETDVELHRQRRKQLSNFFSKMSIRSIEGILLSKVATLCKRISETRFNGPVNFYQTFRKHLHNAPFLETFDLAANSFWDIEHFSILRVIISSVPSAVAGKLSRSAARLQGLLLAVADTVTKFRRLKSSGKSFDHVVVFDKLSDLDDVRLQGEAADILVAGSDTTATTLAVAIEQIIERPAVYTRLRKELRDAGFLRERDYELQKLEQLPYLSSCVKEALRYAMAVPGRLPRIVPEPGMGAEALVVDGKHIPPGACVSISAYSVHFDESIWGADARSFIPERWLTDDGKHLEKYLVTFSKGARQCLGINLAYAEATLTLAMVVNRFRFTADKTLKESDLKRVDNFTMGYEGTGIRAEVHEDYQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6N9</accession>
    <name>A0A1B7Y6N9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156166.1">
        <property type="nucleotide sequence ID" value="XM_018304143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6N9"/>
    <dbReference type="GeneID" id="28868250"/>
    <dbReference type="KEGG" id="chig:CH63R_09169"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09169"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="84" mass="9464" checksum="37533BD699E0DDE6" modified="2016-11-02" version="1">MSPNVWLKSPMATNWRIWTMTFTSIGMTHSRAPELTTDHATPSHVKERPRARERETAIGNNPAWCQTFALDRHTSEAGNGKGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6S4</accession>
    <name>A0A1B7Y6S4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orp1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156217.1">
        <property type="nucleotide sequence ID" value="XM_018304194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6S4"/>
    <dbReference type="GeneID" id="28868301"/>
    <dbReference type="KEGG" id="chig:CH63R_09220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09220"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="899" mass="98518" checksum="2C337E67C17DCD83" modified="2016-11-02" version="1">MDVTSLLNAAAGKKPLIRDNSENTTTTSSVLVFDGQKQQQQHHNTTSSPEKTASFRRTSDARASRNRTPWDAGGYSLPLALDTKLSITQSKPTAYYGESDVDQTASSSSYDVPSSSCHSRASSLSSLAHEMAHSANITPMTSSHHGRTSISGDSDAQLTARPNLPREDDGQQHVTGGFPKSPKHKFSDSHSSLSSYTSSNQSGGHSRISSLSTVSGIQPFTSLLNEVPAFDAKLADQQQNMPGPGVVDIQPPSPRTMAHHELALDPAMKGPGRPGSPSDAILITRGMGGSNRSSPTDGLSPHSKQQQDNLNYLSLPQDNSHPRTHKRTVSAPDFAAISAPTFQPFPSVSETAPFPPQQQSYGMSPPQSPPATAANDEIKCMYIENCDTGSQPRKAISHIFGRNKLCTRMIPAHVWVHFCRKHYQRSRYRNAHEYSKLQVDLVQKQIARVQQWSDENDRAGKAGVVNSWSLAIRKREQKRLEDKKESKKRSYQDDSEDEQLDGAMLNGTAVPEWLLNKCGAGYTTVAIQEIVAQLKTEIDNGGLSQIPDIEILPTISSDGPDEKPKTYLKRKTSGGAAHKRSQSMGVALRPEALPMTRRVSQPNAYWGQEGFDATSFEKRQRMTDMEAGFYGDRNAIPGMARVPSGMRRMNIPHRPAFGNIRENHPEEDYYRQPQMASGPFVFGAGGPQGGPLPAPTPQRRGSKSMASHLETSTTVPTYPDPRRAFHQRSQSEMTGFHQGQAPTYRPNSSSGFGPYGYGPSPVEQPQDQYNGAYARHDNPFAQAAQPNYYEDPQRQYSYGAPSFQPNPTPRLGPSGPNRHARHQSTPNAPGAMNRAPSAHGFAVGTGMAPRHDQQQGYDRPPSEQSRHSSYATPPMQSMQPMQPMQPMQPMQPMPDGARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y746</accession>
    <name>A0A1B7Y746_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156312.1">
        <property type="nucleotide sequence ID" value="XM_018304289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y746"/>
    <dbReference type="GeneID" id="28868396"/>
    <dbReference type="KEGG" id="chig:CH63R_09315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09315"/>
    <dbReference type="OrthoDB" id="10587922at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601392" evidence="2">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="468" mass="47977" checksum="F52000387C14CF9B" modified="2016-11-02" version="1">MKLAVTATAVLAGLAQANYLVAVDKIAAQAPTATARPLIWAPPPKHDFPAPGDPAPTSVVQTQVTRVFTPLPSPSPVTATTKVSASTKASATTKASASTKASASTKASATTKASASTKASATTKASASTKKPTTTSKKDTTSTKKPTTTSKKDTTSTKKPTTTSKKDTTSTKKPTTTSKKDTTSTKKPTTTSKKDNVTPCKSSSAKKPVTTPCKSSSTKKPVTTPCKSSSTKKPVTTPCKSSSTKKPVTTPCKSSSTKKPVTSPCKSSSTKKPVTSPCKSSSTKKPVTTPCNSSSTKKPVTTPCTTLKKIVTPCKSSTKVTTTPCNTAKKSTIHKIITSTRRANITSAVVHKTSAIVVVVPPSSKPVAVSTQRAVPVKSPCPTVTRYQNSTATAARPHVKSAQPPAQPPAQPPAKSPTQPSVKPPVKPPVEPSPPTPSKPSTVPTAGGNNVKVSLSLASVVLVAIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7E0</accession>
    <name>A0A1B7Y7E0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TOXD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_09493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156490.1">
        <property type="nucleotide sequence ID" value="XM_018304467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7E0"/>
    <dbReference type="GeneID" id="28868574"/>
    <dbReference type="KEGG" id="chig:CH63R_09493"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09493"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="38729" checksum="93DB0E02AB0DDB2C" modified="2016-11-02" version="1">MKALVSNRSIAARLFNHSTGKSGFKGAHVIDVPRPKITGQEILVKVKAVALNPSDYKHIDVISPKNCILGCDYAGEVVEVGPSAKTSWKVGDRVAGVVHGGLYRDRGAFAEYLKTEADLAWKIPSGVSDEEATTYGVSAVTAVLALNVHLDIPWPNETNQSQEPKRTILIYGGSTSVGLFAIQLAKRAGYTVVTTASPHSYDLVKRYGADKVFNYRSERWVKEVSSAYPDITLALDCISEKGSGPSTAQVLKAKGGKIVTLLDQGESNVPGVKYDMIMLYTVFGKEFAWLPPVGPKFPVDVEHRAALVRFYASLPQLTDVVKPPPIEVFDGGIDVLLEKVDLLRQGKVSGTKLVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7Z4</accession>
    <name>A0A1B7Y7Z4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_09680</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156677.1">
        <property type="nucleotide sequence ID" value="XM_018304654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7Z4"/>
    <dbReference type="GeneID" id="28868761"/>
    <dbReference type="KEGG" id="chig:CH63R_09680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09680"/>
    <dbReference type="OrthoDB" id="5230128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF39">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="15">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR08159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="339" mass="35951" checksum="EDC44098915F96A1" modified="2016-11-02" version="1">MSRAMGLEGALDVETLLGVAHPVPVVAWNVGGRPPFQPSSNKDQNSNEPYLEWLHHLAALDDAALPRVVSVSYADEEQTVPPRYAARVCEAFAQLGARGVSVIVASGDEGVGKEGKCVSNDGADTPRFMPAFPASCPYVTAVGGTRHFDPVMAGFDARGGFSTEHADNKAYGSINVLGGGFSNYFPRPRYQEPAVAAYVAGLNTTHGGLYNPQGRGIPDVAAMAYHFPVVWNGTSHLLDGTSASAPTFAAIIALINDALLAEGRPSLGFLNPWLYSSALPGLRDVTIGSNRGCGTMGFPAVEGWDAATGLGTPWFPVLKHLALRDAFRWDHPWYVADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y953</accession>
    <name>A0A1B7Y953_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156973.1">
        <property type="nucleotide sequence ID" value="XM_018302195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y953"/>
    <dbReference type="GeneID" id="28866302"/>
    <dbReference type="KEGG" id="chig:CH63R_07220"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07220"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="125" mass="13250" checksum="D07D05E0805DC5DA" modified="2016-11-02" version="1">MPILVLLAMDAAMAFQPGRHTNGGPAASASAAAGKARKQGPDLSRPPARPLARSTPLPLLISSHERQASSVVTRLIDKKRASLGSSVPSRARALGAPPPFRPPFMKLDTDALDWRRRPPSLSSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y954</accession>
    <name>A0A1B7Y954_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157107.1">
        <property type="nucleotide sequence ID" value="XM_018302329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y954"/>
    <dbReference type="GeneID" id="28866436"/>
    <dbReference type="KEGG" id="chig:CH63R_07354"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07354"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16114" checksum="F298069FB644EB82" modified="2016-11-02" version="1">MGDIGTELNRLQIPRHAIRTTCFILFDFQAAARNGAKPGSAVRSGSPLLQILGCAALARFTFVDGPVSVTRSPEVRVDLVSALLAADRRHSRHMLSTAVCRVWFMAATPSPPLFPCLLFHPLGGISVAHGRGREMSQPRPMTGQKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9R1</accession>
    <name>A0A1B7Y9R1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157242.1">
        <property type="nucleotide sequence ID" value="XM_018302464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9R1"/>
    <dbReference type="GeneID" id="28866571"/>
    <dbReference type="KEGG" id="chig:CH63R_07489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07489"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="968" mass="101908" checksum="D7F6803A4BD6A1FE" modified="2016-11-02" version="1">MSHPQYGKDMDRPSIAGSVKRARERAQAGFLREQNSPPGATRFPIVEEDPDSPTDVSERRQVGESPPSRIPRPQPPAALQNKDGGIGVAISRPTQIPQWPLPGPILSPANNPDAEPYRPPPGRGPPPQRPPRPSRVPSILDSSRVQDHTPVFQYTPQSGRESVLSQEISSTPLTPSSRHTQSSLSSVGSIPDFPLPAAIPPVAAPPPVAPPRRSVTLGPPPSSRRGDSSFYSNASFVSPIPEESPRSRSHTSFASSAAMPESWGSQSPGFSPGYPDDYYGDDAYSTEDENSQMSRGSGSPYGDVGDESKLVRSASLGKMSKPSIVMNRAPSSGDPLPQEAQSVSELQEPPPRPSPSPMQLPVSPFESGTAYYEGSSSSGTVPTVAATANTPSLTPDAMLGAFAAASATDPADMRKVTPSPRPYDRLSAIRRPPKLGLDMDSVRAMESRGSMTSLPDLIKRATRLAALIDRGRRPGSRFEIGDGTWPDEKAFGREGDQQVSGMSSAEKHQSGLSDMLAAFPPPAATTPNPPNRGSWFRRASTASWPLAPGSRGSTPQPVTRAMAARGSPLAILESNDEQSSTRPRRRCCGLPLWAFIVIVIIVLGIVAAAIVVPLEFLVFRRNRTSTPTAEPALNQCQNQLRCENGGTNVISQGVCSCICINGFTGQTCSVAGATGCTTTNLMGNSTSTNFSNVTLGQAVPRLLQQARTNFSVPLDGTDILAKFNTENLSCIAQNSLVTFDGRSSRVGTPTSAVDVVANAAIPVEVIVIPPGEAATVTIDINAPGAVVLPSPDIVGGFTTLTGPFRVTTIYATSSTKWATIPVISSPTSLPETTPPVSLPATTTAPSPPSPPTTMTTMTTTPQGPLFPSIPVPSAPAPNPRFMVTEETLDFARVSVLLILERQSLMAATTAQTVLQRFFTTADQGGRQQNGGVTPTQALNVTLGGGNSVDLVNFLITIPGGIQAGGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAQ7</accession>
    <name>A0A1B7YAQ7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 15">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_07810</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 15"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157562.1">
        <property type="nucleotide sequence ID" value="XM_018302784.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28866891"/>
    <dbReference type="KEGG" id="chig:CH63R_07810"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07810"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="HATPase_TopII-like"/>
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        <property type="entry name" value="TOP4c"/>
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        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
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        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
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    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_C"/>
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    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TOPOISOMERASE_II"/>
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    </dbReference>
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        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="560"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="18">
        <location>
            <begin position="813"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1194"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1302"/>
            <end position="1335"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1347"/>
            <end position="1562"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1592"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1205"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1311"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1348"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1359"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1416"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1444"/>
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        </location>
    </feature>
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        <location>
            <begin position="1470"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
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        <location>
            <begin position="1666"/>
            <end position="1685"/>
        </location>
    </feature>
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            <begin position="1704"/>
            <end position="1720"/>
        </location>
    </feature>
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        <location>
            <begin position="1729"/>
            <end position="1741"/>
        </location>
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            <begin position="1747"/>
            <end position="1759"/>
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        <location>
            <begin position="1768"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00011080"/>
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            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023029"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1796" mass="200601" checksum="AFC1C496E6E3DE6E" modified="2016-11-02" version="1">MSMLPPPKPLPKQGAVAPRLAIPQTNTRPNTDPSQKPKAKAAAVKKAPAKKLTQTTLKTKAVPKKRAKPESDDEDGASTFSNTPPSAKKLKKAPAAKKSSGNPLAEIENDSMMIDNDDEPASGPKSKKTATDTYQKLTQLEHIIKRPDTYIGSVEPTEQPMWVFNKETKLMEYRKVTFVPGLYKIFDEILVNAADNKQRDATMTYMKISVDREAGEITVENNGKGIPVEIHGKEKIYIPEMIFGHLLTGSNYDDDEKKTVGGRNGYGAKLCNVFSEQFTLECQDSNSGKRYKQVWTDNMSKCGKAKITSSKTSDFVRVTFKPDFKRFSMTGIDDDLEALIYRRVYDMAGTVRGIKVHMNGTHIKLAFKGYCEMYAKAIAKERGAEEGVEPKVVVEVDKTDAHPRWEIAFTVSDGSFQQVSFVNSIATTSGGTHVNYIADQITGSLLKTLDKKKKGHALKQNHIRNHIFIFVNCLVNNPAFTSQTKEQMTTKVSQFGSKCSLTEEFLKKIAKSDAIQNIIDFAEKKADKMMAKSDGNKRSRISNSKLVDANLAGTRHGHECTLILTEGDSAKSLAVAGRAILDPDRIGVFPLRGKMLNVRDASIDQITKNQEIQNIKQFLGLKHKQTYTDTKSLRYGHLMIMADQDHDGSHIKGLLINFLQVQYPSLLQIPDFFREFITPIVKVWQGPNPKKPARLKSFFTQPQYEEWKELHKSELSRWHYKYFKGLGTSSNEDAQVYFTNLDDHLKEFDTMKPEEVELFDLAFSKKKADARKEWLGNFVPGTFLDHSTKSITYTDFVNRELILFSMADNMRSIPSVVDGLKPGQRKVMYACFKRNLVKDQKVVELAGYISEQTSYHHGEASLQQTIIGLAQNFVGSNNINCLEPSGNFGSRLAGGSDAASPRYIHTRLSPFARKIFSALDEPNLEPQYEDGKRIEPKVYAPIIPMILCNGADGIGTGWSTSIPNYHPIDIVNNLKRRMGRLDESTPEDAAFQPMMPWFRGWKGTPEQSEKDRYKFNGICELDERTGEVVVTELPIRMWTDDFKAKLEEVISGVKGPVWIKDYKEFNDHKNVHFVIQMDDKHSKDVLADGLMERFKLSKQVATSNLVAFDTRGQIRKYEKVEEILEEFYNYRLDMYAQRKKHWLGVYHSDYRKLSEQARFIREIIDGKLIVAKKKKQVLVEELAKRKYEAFPKNKDKNAKKKSTDEDMEGNDEDEEDNDEQTNGYDYLLSMPIWSLTYERLERLQRQIDNKKAEHDALLALSEKDLWTQDLDEFVAEWENQMALDAEIQTNIRRLGRRVSKKIGAGKGRKAKKDDDDYAPVEKKRAGAKAKAAPKVAEKAAERFVAMFEKSKVKPKKEEAESDAFSDDDFAALGRKGTAKPAAPSETRPRAAATKKKPIYTLSESDDDEDFAALGKKSTSVPVESATEDNSSQSQKPVAAKKPSPRVEELDSDDDFKNLEGKKSSGEKPVTKPAPKAVVKPAAVETAAKDSTSRTQRATSAKKFVIDESSELSDDHFQSVEEKSDSPEPAPTKPSANGRGQRAAASKKSKYVLDDESESDINDSQIGDIGALVRGIGAPKAETEKGRLSLFAMNRPDRRDSTLPKMKTKASRNFDDDSVDDTNYEMLARSSPHKTFTKGDDIDSFLSDDGAPAAKLSKASTSKEAKGGPAAAAPAKKARGRPAGTKNKPKDAEAAPKPKPKAKAAPKQPALSPAAKAYAAKKATKRVLSDDEDDDVEMEEPESPPRPAARSRPGRAAAAKAKAKPTYVIDDDDDDDDSEMAVGDPESEDPFDMDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBC5</accession>
    <name>A0A1B7YBC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stromal membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157889.1">
        <property type="nucleotide sequence ID" value="XM_018303111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBC5"/>
    <dbReference type="GeneID" id="28867218"/>
    <dbReference type="KEGG" id="chig:CH63R_08137"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08137"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="578" mass="59808" checksum="F70C5D7B62367EF7" modified="2016-11-02" version="1">MSRRPPPNPAAERAAQNQLTIKSLLKLESNKVCADCKKNKHPRWASWNLGVFICIRCSGIHRGMGTHISRVKSVDLDSWTDEQLRSILSWGNARANKYWEAKLASGHVPSESKIENFIRTKYELKRWTMDGPIPDPASLDVDGDDDVPLSLVKEKQNVERRESVRKGSVGNSAAPSRNVTSPQPQVDLIGGDPIPRASTAGPQTGKVPPKSDPAPPKATSTKDSLLGLDFFGEPAAPPRPASTNNAGGMGGTSRPDLKQSILSLYASAPRPQPQQQQQQQQQQQAPQVTGGAFGGMPSPTFGHQQQQSFGGMTDAFSSLSFSNTTSPKPAQADPFASLASPGNSRSPPPASNNAFGGLSGGSFFDAKPAAPAPLTHQKQPSSSSFGGFGWSSSPVPAPAQSQPKPTQPASSMGDLFDLSAPSQPAAAPSKPSPTPAASSVFNLSSNQAKSPPPAATSTISSGNWSNSDVWGSNAWSTPDTNSAAAVPVAKPAEAPKPAFGGTGDFGGWGSSGVSSGLPTGSFANTPIVPGSSGGFSAAPKVAADEEFGGWTSSAEPAAGAGSAKPVGGSEDLFSNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBQ9</accession>
    <name>A0A1B7YBQ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157787.1">
        <property type="nucleotide sequence ID" value="XM_018303009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBQ9"/>
    <dbReference type="GeneID" id="28867116"/>
    <dbReference type="KEGG" id="chig:CH63R_08035"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08035"/>
    <dbReference type="OrthoDB" id="3597252at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="651" mass="72782" checksum="699FFF2B1DC489BD" modified="2016-11-02" version="1">MTTKQPRKRTLDLDEDPLPVTPSSTPISTPSPGDDLDIASQDYQVWSPPSEFPPSHAESNPTTRRRRLSKSQSHRHRLAASSVASHPGFPSNSSTLGPLYGPPVSPRRSANVVFSPVLPPPESRYVEHLALSNPFDDNADDENRLVLGQRPIQRGAKVDGYIKFHNEKKKVASEAHVAIFQCKGSGQEYSPKSTLAIYLSPQYMGEMGLQDNDDRSLFAFYLKAWCPGRSVLDQTNCWFENIPRMASKDSCVRSAILALAGTYVLDYQPRERIRQVAQRHYKTAVILLNMALRDARKQLPTENEANCMVAAIALLNMIDVVSPEQRRPPNCVPRWLEGARLACRMLDATDPGHRYWNPVNIQPSEAQTGNMIIAGRAAILALPMTPLDLAATDNHQFAWLLQGSEHDVHRVHGGCGMSPTLLHRFSQITHLSAFLSAHPIDSEFLIKASVDELLGDLRNLRQWTESASSSAVSRPDKSRDISLPSDLLSSIKLGKHGLIVDRNSMTEVTAEAWRLAAIIYLRCRLERLPRSHPDVVSQISELAKCIRVMPTSGTFFTAQAPFFPVFLLGVLALHESHVQCALDWFHSVISTSCRSSVPPAFRSLERVRAWMDPNIHDMNPSELPRRIFERYPWWETLVAHIVSTEGTLCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDN2</accession>
    <name>A0A1B7YDN2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylserotonin methytransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158636.1">
        <property type="nucleotide sequence ID" value="XM_018300786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDN2"/>
    <dbReference type="GeneID" id="28864893"/>
    <dbReference type="KEGG" id="chig:CH63R_05811"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05811"/>
    <dbReference type="OrthoDB" id="5383338at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="607" mass="66903" checksum="25A7DB97C64A6C6D" modified="2016-11-02" version="1">MSTQPPSGGYSLFPNPNAKPPTIWRPASRTRRSESRERARAVSPESVHSADRASPPHHGRQTPQQRVQSQVERSQTPQSIRQTQVGEQETAPNRREVPAPPSVTVAPVQRPPPVADILPRSDTSFSQEHTLVQSNSTRSRSSIAKLPFPEGPSSSSQEQPALRSIFPRYNPEVPLNQQDYFPTQTSPTHIPRAVINRTTWYPDPEGDGQNNQHRSPVRSPLSGGSTQRWPRRNIEPPVIPSVSANEHMKSLWKVSNGWKAPPSEGRVYCMKLSQEKDAPIYTLSSSSQPFYSLRLDPTSASAYVTLSRHDPAKVYKVPNPTASSSASSILSGVVGHKDNGKAADGKHWQEVLTTTLEEESRKHPPNDGLVALLYPLAAAKMALDKPDDMNAIMTAETECARLVWDEDSGSHFLVHPALATPFCVTIERSPAWSRVEYTLEHHESPQHLAKLTRDGTGSGHLEVDTAIAAKIDSFFLVDVAVTALLLVAVADEKNTRIETFEPPPAPHEPASGERRLSRREEKKRAAAAARRGKMEEFEIDIESQDSSFAKLEQAGKEARDGLPWPLRALFKVVAGLFKCLVWFLTLGFKALAAIVKGLARCLGVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE69</accession>
    <name>A0A1B7YE69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Raffinose synthase Sip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158625.1">
        <property type="nucleotide sequence ID" value="XM_018300775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE69"/>
    <dbReference type="GeneID" id="28864882"/>
    <dbReference type="KEGG" id="chig:CH63R_05800"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05800"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="920" mass="102214" checksum="1FEDDCCFBBEDF62D" modified="2016-11-02" version="1">MSSDNYNFADVFQAVFISKQKPAPEPIAEKMKALIQSYPPLGQYTQVSNGRLTVTAVLEIPASRANEPWEVALWHSSDGAEWAETVLARVLNENAPTTLQTVPDHVRRLFYSASIAFNKSLQFTLKFRHSNSEPWRWTRDELGVGDGTVVLNAKPVFESVSERFDDIVPDLNPAWEVKSLMSQCPGTRLWSLKAAVDGVEGDVSQLADFSLGVPWGGFLRWFALIRIWSPWLAPRHGRDSLALDKDGVLCSFLSPEGKHLVFLAVSGVNNVLSVFRNNESGQLSVHVRIASLDDCSFPYAHNMQARNDGIHSESAIILAATGDNFESANAAVMYQARNYILQEKKASNELLAEMKAIDEGVKPEWMENWYDGLGYCTWNALGQRLTEEKVLNALDKLEENNIKVTSLIIDDNWQTIDYRGHGQFQHGWVEFEADPKAFPKGLKATVAQIRQNHPHIQHIAVWHALLGYWAGISPDGKIAQQYKTVDVIREDAERRNLPLGGKMTVVAKEDVDRFYNDFYKFLSDSGIQGVKTDAQFMTDTWTSASARRELIDAYLDAWTISSLRHFSIKTISCMSQTPQIMFYNQMPRNRPAILCRNSDDFFPEIPASHPWHVWTNAHNSLLTQHLNVLPDWDMFQTVHDYSGFHAAARCVSGGPIYITDVPGQHNLDLIKQMTGPTIRGKTVILRPSVVGKTTDPYTGYDDDGLLKVGSYHGAAVTGTPILGVFNVSARPLTEILPLASFSGVLPSMRYVVRAHSTGKVSPPVSPGSTASSLTVSLDTRGYDIFTAYPLSSFDSEVKGKVWTANLGLVGKMTGAAAILNSDFLLRHDGKVELKTRLKALGVLGLFISKLPELTIGDDFLITIQNQVIPVHTVSISKSHDSVIEIDIEKAWYEMGLHPGWSNEVEITVIFAIDHEGSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEF7</accession>
    <name>A0A1B7YEF7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158984.1">
        <property type="nucleotide sequence ID" value="XM_018301134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEF7"/>
    <dbReference type="GeneID" id="28865241"/>
    <dbReference type="KEGG" id="chig:CH63R_06159"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06159"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="18612" checksum="0166CA0E714A521E" modified="2016-11-02" version="1">MSAPVSNQVGNLGQSVAVLDASVSPDGQIGSPQFLDAVNSLLLVFGQAAYIQTLIQAERASGQHEATEALLWLTRGLEFYVASARRIANNTSEKLSDSIMSAYKDTLKKHHGFVAKTAIKVAVSKTCPTRDALLRKLGQDPTMIVNALQASATSFERVLHVLAPFLARSDIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF63</accession>
    <name>A0A1B7YF63_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unsaturated glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159087.1">
        <property type="nucleotide sequence ID" value="XM_018301237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF63"/>
    <dbReference type="GeneID" id="28865344"/>
    <dbReference type="KEGG" id="chig:CH63R_06262"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06262"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000048">
        <property type="entry name" value="Unsaturated chondroitin disaccharide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="523" mass="57158" checksum="9158DEE43E8C14C9" modified="2016-11-02" version="1">MSHLNLTSPGSTLADGLSATTNAAYAESDSTTELNADSDTSISETGGLSDPGSRRKMGHSKPIREQVGGLYEENVTAKIFRTAANALVGNNPPTAYPEYVLQTGPDAGKYILREASFWTCGFFPGSIYSLIERLVKFPQTMPGGEDKAALLSKLWSLGAAWSEPLHATARRTDTHDMSFMIQPSMRVRWEVAQDRRALEAIVTAARALRTRYNATVGAIRSWDALTQHGVDITSLTDDFLVIIDSMCNLDLLYYAAAHTGDADLAEAATTHARTLMAANLRPETDPRGVVQGKLYSTIHVVNFDPKDGGVKERRTGQGYAVESTWARGQAWAILGYAQTFLWTGDAEFLDVARGLAEYFILRLETSPDSVEFPVEGGGEGGERRTKGRYVPLWDFDAPIENEAFPLRDSSAGVIAANGMLVLSQALAGRGRAAESARFRDMAVRIVADTLDFSLAAEKAEFVFGDGDIGTRDVEEGRTFDAVLKNATANHNARDHKRYWDHGLVYGDYYLIEFGNRLLKMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFR4</accession>
    <name>A0A1B7YFR4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_06625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159450.1">
        <property type="nucleotide sequence ID" value="XM_018301600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFR4"/>
    <dbReference type="GeneID" id="28865707"/>
    <dbReference type="KEGG" id="chig:CH63R_06625"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06625"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF147">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="561" mass="62975" checksum="2F2162B684A45E50" modified="2016-11-02" version="1">MRCDNLYFPFAPQLGIQLPFHHSFSAVAPTNTMSTTLETAPSPIDASTSYLSARNILGLVGIWLAYQLFKALYNISPLHPLSHIPGPKLSAATYIPEFYYDVILFGRYTREIHRMHEQYGPIVRINPHEVHCNDVNFADEIYAVSGRKRDKPVHQINGSALGESGFGTVDHDLHRARRGPLAKFFSRSMISRLEGDVHALVQKLCDKLLAETDKKEPFDVTMAYSCFTSDAISGYCFGESFGFLKQEDWYPNFRAPTASILRPVFVFRFFPRTKHLAVLGEWLVDYLPTDIALMIRTLKMEIPNRVDNTKAELDAGIRHERPTVFGSLLESDLKLAEKGSLRLADEAAAVVGAGTETTSWALAVITYHLLTKPEMLEKLQAELRSVVDDPKHLPSWTSLENLPYLGAVLQEGLRLSYGVSARTARVATEENIVYRGEFNKKPVEYVIPSGYAVGMSAVITHHDESVFPDSYQFAPERWLDENNQRRKDVEKGMLAFSKGSRSCLGMNLALCELNLCLTALALRVLPTMRLYDTTDEDVAYDHDMFVPVPKAGTTGVRVKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YG45</accession>
    <name>A0A1B7YG45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159371.1">
        <property type="nucleotide sequence ID" value="XM_018301521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YG45"/>
    <dbReference type="GeneID" id="28865628"/>
    <dbReference type="KEGG" id="chig:CH63R_06546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06546"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="731" mass="80762" checksum="FCACEA8030FEB359" modified="2016-11-02" version="1">MTKHVPTAQAKTDNMNIRSYSPDKLTATGIDESSLLIHQDGYLEPSWRPSRSVSGTAGEVVDNDHTTIAPSDISTPPRRHSSSSAIESTKYMGLRSDVDPTDNDTPGERIALTSFDNESNTAFITESRPLKETITSQDVTDKANETIWDAWWLETLSSLLALGCIIAIVVILSLHQGKPLPDWPALISVNSLTAIFTAVFKASLILPIAEGLGQLKWNWFHRPQKLADVALFDNASRGPWGSLLLIIKQIPRPHKSYLAGFGSLITIAALAIDPVSQAMIEHRECHLTREPGVVEVAEVPRTNNYTASDVYVFDHFKTQLDLSPTMEVALHKGLWDPEETETMIQFQCPTGDCTFTKGNDSFFFSSLAMCHSCKDITNDVVLEHDPDGHRAWHLNVSQEQRWPFSGPQVCSALRNKPKLSVTSTPGNVYRHGQEPFLSFDVLMITLPACKENASSCYYKDHTVSMLKPVAVRCSLDPLINGEERQCFATADWAPQSVRVDSTYGSLYKVGDPPEDSNLVWKSYPRECVWAVGSSSSLSIDDALKDLFNNNISTTDLEHVSNVTGPTWLKKVYAEGPGNLSTVESMIQGLTKSMTAAIRNDPGGPVPPDRLALDESQRSLRKVRGSVSSTQTCVFVHWGWIAYPAALLVLQWTFSILMLVTQWPDNGGKTRTRSTWKSSPLALLFHGLDEGLRRSHGNLRTLKDMDAAAKKLNVQLAPVDGSKDKGWLLCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGP1</accession>
    <name>A0A1B7YGP1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_06670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159495.1">
        <property type="nucleotide sequence ID" value="XM_018301645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGP1"/>
    <dbReference type="GeneID" id="28865752"/>
    <dbReference type="KEGG" id="chig:CH63R_06670"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06670"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="449"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="847" mass="95886" checksum="2078170BCBFBBE92" modified="2016-11-02" version="1">MTSDSDPPPSASAPPPPPQRPRSPSGSFYALSDDEEGDYDTITHTETGRGVKLLFSKSKVYVHPTPSAKDNIPGYIALLQQKGGRHDRPTSSSSRDSQNPTAHDLLLAWLPETSLGESESIYVKVDLSEGESPPKQSYLVPPPPTVTSHRGSIGTYAFAIPVSAIYSLLVRPPSLGWWFGSLIINSRAGDSFPALFFHDNECQSTILKRKRRTKDSFDPFGDRGEMFWGGDEVLRWLRRYVPIERSGAEPNIYLVDPSKEDSEAFSGKLTSSTAQVGLRDGTGTRAGGAGPSGDAQMDPFVKFVKETGWNIMEKFSKVTTFTRRAAQDVIQNPNVPPQVKRLLRNPEVQTLQDEFDSARIYLARWAMGIAEQSERDRSQRIWTAKEVLELEDTDVGEFELLDGSSTMSLEDRRKPVTLKEWNTFFDQRTGRLSVTIDEVKERVFHGGLDPDDGVRKEAWLFILGVHDWYSTSEERKVQIASLRDEYVKLKGAWWERLVDLGGEGEQGEWWREQRGRIGRLPHEPTGLSDGCADAVAEKDVHRTDRNVPIFAGEDIPHPDPDSPFSEVGTNVHLEQMKDMLLTYNEYNKDLGYVQGMSDLLAPIYAVMQDDAIAFWGFQHFMDRMERNFLRDQSGMRSQLLTLDHLVQFMDPKLYAHLQSADSTNFFFFFRMLLVWYKREFEWMDVLRLWEILWTDYLSSSFHLFVALAILEKHRDVIMTHLQHFDEVLKYVNELSNTMDLDSTLIRAEALFRRFQRLVEAVDKKGNFPGPRLRDPGSPSQSSSSDKGPRQGESSAGPASPRKDTGKAPEESQVKKVITPELRELLSRKVVVLPRKEVAKKGDGPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGS0</accession>
    <name>A0A1B7YGS0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1p/L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159878.1">
        <property type="nucleotide sequence ID" value="XM_018298632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGS0"/>
    <dbReference type="GeneID" id="28862739"/>
    <dbReference type="KEGG" id="chig:CH63R_03657"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03657"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32357" checksum="B8ACBB3C3E8577C7" modified="2016-11-02" version="1">MASTTQCMASMARLALSASTRPTVCTIPRFLVPSVAQTRCASNQGGSKKTDKKKKKVPKDFKTYNVQNCPQFSLCDAMRYLRAYEVGRPPQAVKYEISVHLKTPRNGSVVKNRIRLPNPVKSDVRVGVICPEGSQIAQEAIQAGAVVVGEASVFEAIRNEDIVFNRLICHTESEAALNKAALGRILGPKGLMPNRRMKTITDNISGAIRETMGADNYRERMGAIRMAIGQLGFTPKMLSANVKAFVAHIKDDIAQLDTHKEVHEVVLSTSQGPGFSLNGNYGSTDEKVTPAHLSNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH80</accession>
    <name>A0A1B7YH80_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159695.1">
        <property type="nucleotide sequence ID" value="XM_018301845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH80"/>
    <dbReference type="GeneID" id="28865952"/>
    <dbReference type="KEGG" id="chig:CH63R_06870"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06870"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="29721" checksum="EE392F34473693BE" modified="2016-11-02" version="1">MSDIEVLSEFGAKRRRGVLEAFSTVNRMHYTISRDDTTSDHSRQERTLWDWAEETRQRRSPLFPSGHDGFATRRKNIPEAGDAVLVAHLGGGSLPDVAHALPLVDDVSSARRESLYQARAQSRTTASLSASQTHTVYRYETYAYRSEDEDGSQTSITDEDDFYNDTASLPGDDDNVGFFESVSSPGEHEWGGEESATQANISSADKPRVRQATSYEKPSRDQQDDIIEFEPERRRREDRDRQREKLPTIRKQLKAFKRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHM5</accession>
    <name>A0A1B7YHM5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_03869</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160090.1">
        <property type="nucleotide sequence ID" value="XM_018298844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHM5"/>
    <dbReference type="GeneID" id="28862951"/>
    <dbReference type="KEGG" id="chig:CH63R_03869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03869"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="14">
        <location>
            <begin position="112"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="262" mass="28666" checksum="531FD7A604A49E30" modified="2016-11-02" version="1">MAGGGPHHDGGDPASKHKKQQENNKNNADASFPEYARRTAEKLPPPTFIILALLFGLYIIFSSSQQNQRSAADLSSSPVVPSVVTTTIYHEQQQHTPPPQHLVVDPSPKMSTEQTFIAIKPDGVQRGLIGPIVSRFESRGFKLVAIKLVTPGKDHLEAHYADLKDKPFFGGLIQYMLSGPICAMVWEGRDAVKTGRTILGATNPLASAPGTIRGDYAIDVGRNVCHGSDSVENAKKEIALWFKDGEAVQYKSSQFDWIYEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIG0</accession>
    <name>A0A1B7YIG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160353.1">
        <property type="nucleotide sequence ID" value="XM_018299107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIG0"/>
    <dbReference type="GeneID" id="28863214"/>
    <dbReference type="KEGG" id="chig:CH63R_04132"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04132"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="18238" checksum="AC534F9CD5048467" modified="2016-11-02" version="1">MPFFSNPYRAAALAARRVWENITRWSWQLFSYSVLARGCVQRLARYRCPLAFPLQSLAGGQLEEHGIIVSRTPPIRLGYMHASRSLGHGRPPGDFGFDAAPPFRRRREVWGRGFEPIAADLRWRAPNPIYIYGWRGAARLKLQLPRRPRDETEGCSNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIV8</accession>
    <name>A0A1B7YIV8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ heat shock family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_04282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160503.1">
        <property type="nucleotide sequence ID" value="XM_018299257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIV8"/>
    <dbReference type="GeneID" id="28863364"/>
    <dbReference type="KEGG" id="chig:CH63R_04282"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04282"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="40341" checksum="F84B279F6A4DAC05" modified="2016-11-02" version="1">MVKETKLYDQLGVSPSATQDEIKKGYRKAALKYHPDKNKDNPQAAEKFKECSQAYEILSDPEKRKTYDDYGLEFLLRGGAAPPPEAGGNPFAGGGMPGGFDFGSGGMPGGGGARTFRFSTGGGNGGGFNFSSADDIFAEFMRSGAGGMGGGGSGGMDDFENIFPGFGAGGQRGGGRSQRMRNSGFGDSPRPRESTPEVTTVERPLPLTLEELFRGVTKKMKIKRKTFDDTGKRTTTDTVLEVPIKPGLKKGSKIKFKGVGDQEEGGQQDLHFILEEKPHPLFVREDNDLVHTVELDLKEALTGWRRTVTTIDGKQLNLDKNGPTQPGSSDRYPGLGMPISKKPGSRGDFVIKYNVKFPSSLTAEQKQKLREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ59</accession>
    <name>A0A1B7YJ59_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_04346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160567.1">
        <property type="nucleotide sequence ID" value="XM_018299321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ59"/>
    <dbReference type="GeneID" id="28863428"/>
    <dbReference type="KEGG" id="chig:CH63R_04346"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04346"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000112">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="183"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="654" mass="71323" checksum="616ECD8C072C530E" modified="2016-11-02" version="1">MDDDSDDPRQDELGSLQAIFPEIQPDDRRPYCFTIELPVHPAKPVTVTFPAAANAEDAAAAQLLPGAEPRVDSHELSHLPAVVVRIDLPEGYPSEKPPNVSISTSPPWLTRDVTKKLEGDGQRLWEEMGRDMVVFTYIDHIQQASDDVFGMVDGNGTLEIDPSHKIAILDYDIEATRASFEKETFDCGICLDPKKGSVCHKMLDCGHIFCIQCLQEFYDNAITEGDLATVRCLAPNCSKERAEAGRSSGKGKKRKVKTSISPSELLQMGLSQETVTRYVTLKYKNELESDKNTIYCPRSWCQGAARSKKHRKPEGLEVVDESSDEDTEDEEGAEGQGGANGKKIKAFNSGDLLAICEDCGFAFCSRCYQSWHGEFYRCMPKRDQGELSAEEQASIDYINLHTTPCPTCGATAQKSHGCNHMICFRCASHFCYLCSAWLDPRNPYAHFNEQPNGKFTSCYMRLWELEAGDGDNVDYGFAGGAREAQNEAPEPVEIIDIIPEIEEPDDSESDTEADDVHGPPPPPAGGVAREGPLVLRIGADPAPRGGRGGAAGAGAAHGPVPPAAPPAPVNPARRGGPLVRGARGGRGNRGVDARGGRRQNPPRNQAHRVPVVNRNGEIGIGLVQDGELDPVQEAWIRRFVQMALDDEEDDSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJV5</accession>
    <name>A0A1B7YJV5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_04606</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="18">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="18"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160827.1">
        <property type="nucleotide sequence ID" value="XM_018299581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJV5"/>
    <dbReference type="SMR" id="A0A1B7YJV5"/>
    <dbReference type="GeneID" id="28863688"/>
    <dbReference type="KEGG" id="chig:CH63R_04606"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04606"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="41112" checksum="C220741BBBCBFA1A" modified="2016-11-02" version="1">MAEFIRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINGIASENTLRFVKSLPKRERQPLKNKFKNADPSAIDLLERMLVFDPKKRITATEALSHDYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVDASAQQMEEQFNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL65</accession>
    <name>A0A1B7YL65_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_05051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161272.1">
        <property type="nucleotide sequence ID" value="XM_018300026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL65"/>
    <dbReference type="GeneID" id="28864133"/>
    <dbReference type="KEGG" id="chig:CH63R_05051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05051"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="363" mass="38133" checksum="C9B5887DCCD74A8E" modified="2016-11-02" version="1">MRAARYYGREDIRIEEIPEPPCGPNQVKIAPAFVGICGTDLHEYLGGPNFCPASRHPVTGDSIPVTLGHEFSGVIKEIGSEVRAAHLRVGLPCAVQPTVYCGKCAACAAGAENACHTGGFIGLSGGGGGLSEAVSVPADQVFPLPEGVPLELGALVEPLSVAWHAVAAAPVTPESTVLVMGGGPIGLAAVLCLIAKGVKKIIVAEIATARRRFAKDFGATHIINPKEQDVMKETMSITGGIGADVVLDCAGVPASVKAACEAVKTRGTVVNVAIWEKEIPFNPNWVTWRESSYKSVLGYQKADYEAVIENLRTGALKPASMITRKIPLDDLIEHGIKALITDKDNQVKILVDVNASVSEKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL96</accession>
    <name>A0A1B7YL96_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161328.1">
        <property type="nucleotide sequence ID" value="XM_018300082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL96"/>
    <dbReference type="GeneID" id="28864189"/>
    <dbReference type="KEGG" id="chig:CH63R_05107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05107"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601750" evidence="1">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="33"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="321" mass="34688" checksum="CB74468057DBC708" modified="2016-11-02" version="1">MSYFLIASGLLAGVAQAYTQVNVASAFMTKNIDPIVFPGQYDKSHLHSFFGSDAVTVNTKTSAELQKGCTNAENPNDLSVYWIPTPLYTTDGGKTYEPMPVSRFSAYYNLGETPAEVAIPQDVQMVAGDANAQTKSAMPAEAQAEWFCENGGGESLDANGFPSSTCGTHLQQLLYFPQCVNTETLETAYKDRRGGSCPSGMKSMPQLRFSIRYDLRKVLPKGWSGTAPFKLACGPAWCSHGDFINGWTKEAAENMVATTKEKQKFSAVNGGLGDYKSGPTCKSADADPSHGTGDYAESVAAMSKRDVESWGWSTKSRFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLA3</accession>
    <name>A0A1B7YLA3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161312.1">
        <property type="nucleotide sequence ID" value="XM_018300066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLA3"/>
    <dbReference type="GeneID" id="28864173"/>
    <dbReference type="KEGG" id="chig:CH63R_05091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05091"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="706" mass="75730" checksum="F9BF6662BDE7D005" modified="2016-11-02" version="1">MSTMAGGRMRDASVSTLSQMRQLSCAMEAPRRQGLREERGRIARLDLLSLARLLVVFLVVIVILTPVGLHAARLLLLDDLLLCLLDGLEVHAPERAAEVAPRPGVLAADDVARGADGAAVRLRRIREEAQPQADVAQPPPHLGAKPVALGRQPVRVLRLGPLLACEVPLAQRLLRAREPVLGDVPRSLPVRRILLQVAEDAEQPRRVGRRRAALGAGEVGRVEVRNVAAEVLGVRVGVLDDGLPRAVEQAPADEGLGLVLAAVAAARVVVGRGAASEAEGDLGPEAQALEDLEGRDEGADAGPGAHVRRRRVGILGGREEGRRLLGVDGGRRLTGGGDGDGRDLRLVVVGNVFGSGPRGLGGVDDDLVDDGLHLQHASLDGPAAVDLDAGADEQGLGVDLPVGRLVRDDAHGVRQDLLGREGVDGREGVLERRLGQEDDLVERRQLGLLVGRDVRQRRREARGRGRQLTMLAAGLLGEVNLLEQSIVVERHGLGLGLGVAVLRARCRRVCRRVALGEDDKLAGALLLKLCPLSERAREGIREFAQLSRLLQSLARLVVTAKHDVRVGCLEQQLHLLFTRPGVFACRPHVVVEDLLPDGFHAKVDLLRQGRHVDPLRRFGKVGARAERGLAEQLEVPNIDAQAGPRQAEARRRESDYCVAGRRTLGKGVAGEGEELDVGDVRVRRDAVDIEGLEAVLSQRLEDVGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLZ3</accession>
    <name>A0A1B7YLZ3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_01797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161588.1">
        <property type="nucleotide sequence ID" value="XM_018296772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLZ3"/>
    <dbReference type="GeneID" id="28860879"/>
    <dbReference type="KEGG" id="chig:CH63R_01797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01797"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="352"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="542" mass="58926" checksum="486781AE9508A595" modified="2016-11-02" version="1">MRSSSQRKKTIACVGAGYVIHMLTMVAAQGGPSSAILAFQVPEIDVHVLDKSDSRVAAWNSDRPPISEPGLHDVVRATRERARPNLFFSTDMDGLIPKADIIFIAVQTPPTPEDDRSGCDGVAPDLRSFNAAVQQIGSLLTKDAILVNKSTVPCGAAEETARLLQSRLRPGIKCEVLSNPEFLAEGTAVEDLLNPDRVLIGCSSSHAGRAAAAVLGDLYARWVPRERIVTMGTRSCELSKLAANMLLSQRISSINALSAICDKLDADVTDVSRACGMDRRIGPHMLRASIGFGGSCFRKDVLHLAHTARSLALDEVAGYFGSIATLNKHQTERYARRLLQHNVQGARLQIVAVLGFAFKPNTGDTRDSPAISFIRCLVLDGVFVKVFDPIVPKSRILDDVKASLQGLAFIAESRLAVSEDPYEACDGANAVAILNPWDALQFETTQSDSGRLHRKTLFPRFLLPGLGLDNIQADEEPSRRVQWEMIARSMKHPKLLFDGHNFLNRNITSLGFDLQGIGRLSPPRTTRGRGGSSTTFTPRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN82</accession>
    <name>A0A1B7YN82_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162000.1">
        <property type="nucleotide sequence ID" value="XM_018297184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN82"/>
    <dbReference type="GeneID" id="28861291"/>
    <dbReference type="KEGG" id="chig:CH63R_02209"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02209"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="278" mass="30622" checksum="5FCFE9F659AC9902" modified="2016-11-02" version="1">MNFLSKAVLGPWVRFEDEATWRYCANEMLSYISLYATSGTSPITGSMSGESSVFSPVLGRALGICAAHGTLVGTQGRVFNQLIDRELEDLVAASQSAPVHDGRWERRYFEAVVMDTTARMQALTMYQIIRLFSDKARDLQKAAAHEALFASWARELQLQVQMLQQSAPSRGSAAVIGPAVDAADPKVIDAAYRAILISYAVRAVHSVLNDKTCAVWDDLFTLVMPASLSGQARLLYPEYVIQWEMKSTPTLYEDDRRLSDMVVAACKGVDVVVQQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNG0</accession>
    <name>A0A1B7YNG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Oxidoreductase NAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_02188</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161979.1">
        <property type="nucleotide sequence ID" value="XM_018297163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNG0"/>
    <dbReference type="GeneID" id="28861270"/>
    <dbReference type="KEGG" id="chig:CH63R_02188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02188"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="234"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="478" mass="51215" checksum="DBF174E6A297ADCC" modified="2016-11-02" version="1">MATTEGPEFTAKEVAAHREANDCWMVIHGEVYDVSKYIDDHPGGADVLVEAAGVDATEAFDNAGHSEDASEIMATFRVGKLKGVNKRSAPKAVRLAPKSTTAAPASSTAGSAARVASQAAAAALFIGLGAVAARHASSTPAGQDAIAAIQRLNLQLPSWLSLGGAARTKRTGFGFVEGFAVASAFFAVAGSIAAKEASKLLHYEITPMHYRPHQKMPKVAKPNPLNQRGWLDPVSYHPLPLAEKTLLAPNVYRFVFELPTPTTVLGLPIGQHVSIKAEIDGKSVSRSYTPTSNNSDLGRLELVIRCYPDGLLTGKYLANLEVGDEVLFRGPKGAMRYHPNMAKKIGMLAGGTGITPMYQLIRAICEDDRDTTEVSLIYANRSEADILLRNELEAFARRYPKNLKLHYLLDAPPENWTYGVGYVTQEMMAERFPAPGDGSRVMLCGPPGMVAGAKKSLANLGFEKPGAIAKMSDAVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNW7</accession>
    <name>A0A1B7YNW7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic peptide chain release factor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162151.1">
        <property type="nucleotide sequence ID" value="XM_018297335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNW7"/>
    <dbReference type="GeneID" id="28861442"/>
    <dbReference type="KEGG" id="chig:CH63R_02360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02360"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="480" mass="53470" checksum="01F93DD85C0674A1" modified="2016-11-02" version="1">MSDPQANEAEKNIEIWKVKKLIKRLEAARGNGTSMISLIIPPKDQISRAAKMLAEEYGTASNIKSRVNRQSVLSAITSTQQRLKLYNKVPPNGLVVYCGEILTSEGKERKVNIDFEPFKPINTSLYLCDNKFHTEALAELLESDQKFGFIIMDGNGALFGTLSGNTREVVHKFSVDLPKKHGRGGQSALRFARLREEKRHNYVRKVAELAVQNFITNDKPNVAGLILAGSADFKTDLNASDLFDNRLATKVIKVVDVSYGGENGFNQAIELSSETLGNVKFIQEKKLIGKYFEEISQDTGRVCYGIDDTLKALELGAVETLIVFENLEITRWKLKDSQGVEHLLHTTKQQEGGDRAIFMDKETGQEMEVVTQESFLEWIAEHYKDFGTNLEFVSDRSTEGNQFVKGFGGIGGILRYKVNFEQLADIDDDDEYYDARARARAPAEGRSSTPCRQEPDEPGSPHPPSGAPEPASVCYEGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPA2</accession>
    <name>A0A1B7YPA2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine-rich cell wall structural protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162356.1">
        <property type="nucleotide sequence ID" value="XM_018297540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPA2"/>
    <dbReference type="GeneID" id="28861647"/>
    <dbReference type="KEGG" id="chig:CH63R_02565"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02565"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="345" mass="35498" checksum="28AC41D5EA2926D1" modified="2016-11-02" version="1">METISNITNAASKAIWGTNEANQEPVSGVKGNTNQGEPYDAGNIEDPLDKEKKAEVADASTLSGTSGTASTSGPTATTGLTTTVTPSTSTASTDPTGPSTTDDPLKHKATPLTESNLTDRSRTTEDIKPYKSSATEDPSKKKEDIGKPELKNTSTDDAPPADSAAGKTDIRHPADPATDPAPKGQDVTNNASGPITGGDKLDGPGPRPLETVAKERGGDAGNVKKDSTKGGLIEDESASGLEGSKEDVPKAVSRSEGTGEKYIKTSGLAVDGGDFDATKPGAGREADRLLDEKDPAHAAAKAAAASSSDKSTGKTSEDRTHSPKAGTEKEKESLKDKIKAKLHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPV1</accession>
    <name>A0A1B7YPV1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162570.1">
        <property type="nucleotide sequence ID" value="XM_018297754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPV1"/>
    <dbReference type="GeneID" id="28861861"/>
    <dbReference type="KEGG" id="chig:CH63R_02779"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02779"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601823" evidence="6">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="397" mass="42455" checksum="92EDB5DBE27AA6D3" modified="2016-11-02" version="1">MRLASLLLGCSSALLAAGCSGHGGDSKEWTKAELDELEAKWGFERIGFTGIGSFAHLKHAKCLTTPSELYDIAIIGAPFDTAVSYRPGARFGPRAIRQASSRQTSFRGFNPRANVNPYANWATIIDCGDIPVTPMDNVVALEQMSAAFKELGARRPMSSSLSRPKLITLGGDHSLALPALRALKEAYGAPLRVLHFDAHLDTWHPAKYPSYWTATQFNHGSMFWMAGNEGLLSNASSQPSVHAGLRTRLSGTDFADHEDDTAQNWVRIAADDIDEIGTAGVVKAIMDTLGTEDPVYLSIDIDVLDPAFAPGTGTPEPGGWTTRELIRILRGIEGLNLVGADVVEVSPAYQNAGEETALAAAQVVYEVLSSMVKKGLEGMGKAGKAAAAAIEEEKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ40</accession>
    <name>A0A1B7YQ40_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162650.1">
        <property type="nucleotide sequence ID" value="XM_018297834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ40"/>
    <dbReference type="GeneID" id="28861941"/>
    <dbReference type="KEGG" id="chig:CH63R_02859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02859"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="28389" checksum="26E128A33C8F6F16" modified="2016-11-02" version="1">MSNKQPNLFAYPSVDDLAPALRSYVIQAQNAGLSRHGAFKVAVSGGSLPKTLAQALLPPSSGPDDQVHFAKWEIFFADERAVPLDHDDSNYALLKKELLDKIPADQGAPTVHPIDTTYLNDTQELADQYEKTLVTSFASRDSVRLPIFDLLLLGSGPDGHTCSLFPGHELLRETTAWVAPIEDSPKPPPKRITLTLPVVNHAVKIAFVATGAGKKDIMKRIFEHGDGLPCALVNEGAGDRVSWFVDNAAVEGVSYPRRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQB4</accession>
    <name>A0A1B7YQB4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162756.1">
        <property type="nucleotide sequence ID" value="XM_018297940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQB4"/>
    <dbReference type="GeneID" id="28862047"/>
    <dbReference type="KEGG" id="chig:CH63R_02965"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02965"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="272" mass="29660" checksum="DFFD8DE345846D03" modified="2016-11-02" version="1">MASGYDRALSANFRSPDGHVFQVEYAGEAVKRGTCAVGVKGSDVVVLGCEKRSAMKLQDTRITPSKIQLLDTHVCLAFAGLNADARILVDKARLEAQSHRLTVEDPASIEYMTKYVAGVQQRYTQSGGVRPFGISTLIVGFDSGSKVPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNYKEDMDREATIRLAIKSLLEVVQTGAKNIEIALMAPGKTIEMLPVEEIENYVKNIEQEKQEEAAKKKTGRTPGTGSAAILTRGPDSGEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQG6</accession>
    <name>A0A1B7YQG6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein ADR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_02864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162655.1">
        <property type="nucleotide sequence ID" value="XM_018297839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQG6"/>
    <dbReference type="GeneID" id="28861946"/>
    <dbReference type="KEGG" id="chig:CH63R_02864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02864"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="685" mass="76590" checksum="D0D8B953619CDC63" modified="2016-11-02" version="1">MSSRPFTCTECSQTFTRNENLARHKRSRHGSDSRRPFRCQYCKARFTRKDVCKRHEERCRGTFGRVLTIPDMDDGAGQPAPALEDAALSPVDDDDSPASNFQIGASAIENDEGYPHSPPETVEDRRAGELLAIAFGGEMPKLSKQIIVSIGMLYASKSSPEEQVASLSQKSQALWQAGLEELWRLVSPPSPRARCSHQMSNDLIVINQVESDWREIRRTWVMQSWLLHIIYGAFTGNAAHFDKSKKMLRWVVDAARDLGLLRQTIFTSTSRFRDNEEQTLHDHWMSYVESESMKLSMYTLLFLDFHIFSPCNIRPLTTPTELDWELPLAASLWEADTSLTWAQRLGEEPRTVGLTRSHETPGMLCPTTKSLNLAMQSLMTDTPSPHLLAALRASPMATLFVLTSLDSLVRDFTRCYYQLPPALADPNAFHILTQSQNRQVSAALRYLSESITAQISTADSSNWHILNFAERIALSVKLSLCKPDDLLIGGIVENSVVAGLTTATHLTMGLQIGARRSLQNLLRYNSGDDGMLVLLDDLMDVLSSVTSTGRQDPSREAPWATVATYKILLAIWRLLRWAAGETRRKAGSSSRATVRVRFEASTIIFNSILEILQQQEEGGQQLDGGQARRVSVRESAALGMAPEASEARFVETVLQFWKDRPVWPVGSFMTTVLEEVISAGGMVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQN0</accession>
    <name>A0A1B7YQN0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Legume-like lectin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162779.1">
        <property type="nucleotide sequence ID" value="XM_018297963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQN0"/>
    <dbReference type="GeneID" id="28862070"/>
    <dbReference type="KEGG" id="chig:CH63R_02988"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02988"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601836" evidence="9">
        <location>
            <begin position="24"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="343"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="450" mass="49599" checksum="5335279087A30E79" modified="2016-11-02" version="1">MRVSQAPLSSTLAFLLGASLTQAQYLINELSFGYTGSISPNNDGHVPNFVLQGQPNQPEILSNKIILTPVAPGNQRGSIWSTQKVTHSTFIADIDFRANGPERAGGNLNIWLTNGGAADVGMSSAYTAPRFDGLVLVIDGHGGTGGMVRGFLNDRSTDYKAQSDISPLAFGHCQYHYRNLGRPSQIKLRQTDRVFKVEIDGRLCFETDKVKIPPGYTFGITAASADNPDSFEIFKMVVMSDSLHASDNGGQQSQQQQQQQQQQQQQQAHEQKSTQGQPNTNNPRSGNAEPIDLNAIPDSSADAITSSKAQFADLHNRLQSVNHQIGTIFRSVNQYGQQAEHRHAETSQILDSLRQELRKLEKINDLEGRINGLEREIRAMRTDLNLQMKNTEHSLKGYMSDHHATLSSHIVKAAPGHGKLIGVIIGSQVVLVVGYMLYKRRKNSMPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT22</accession>
    <name>A0A1B7YT22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163712.1">
        <property type="nucleotide sequence ID" value="XM_018295350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT22"/>
    <dbReference type="GeneID" id="28859457"/>
    <dbReference type="KEGG" id="chig:CH63R_00375"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00375"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="32861" checksum="242E24171B67DABB" modified="2016-11-02" version="1">MSPSASSNRRDNREEALGSRYSTLNQSFWNERAPAHATSPEYALDRFVSEPAYLSSVVEFDRPLLGDVSGLDCVHLQCHIGTDTLSLARLGARSVTGLDVSGESIRQARLLAQKALDSGGRELRFVQADVYSALGALGPGSYDMVFTGIRALCWLPSISKWADVVSGLLRPGGRLFLREAHPVLWTLDEGDAGGLSLKHPYFESAEPVLRDHQDSYVETDADGGFENVVTGEFNHGLGEIVQALLDAGMRITGLKEHDSLPWRHLSAHMERHENGEWILTEKPERLPHSYTLQAWKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU80</accession>
    <name>A0A1B7YU80_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164114.1">
        <property type="nucleotide sequence ID" value="XM_018295752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU80"/>
    <dbReference type="GeneID" id="28859859"/>
    <dbReference type="KEGG" id="chig:CH63R_00777"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00777"/>
    <dbReference type="OrthoDB" id="5398685at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="64" mass="6957" checksum="82478F50D397CF23" modified="2016-11-02" version="1">MAPASQETESASPTTTRPDGESSVCCVVRICTRFWHSGAARGASRERVTQRAQNFCLDRSPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVC8</accession>
    <name>A0A1B7YVC8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_01153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164490.1">
        <property type="nucleotide sequence ID" value="XM_018296128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVC8"/>
    <dbReference type="GeneID" id="28860235"/>
    <dbReference type="KEGG" id="chig:CH63R_01153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01153"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="217" mass="21696" checksum="7750A70DC003C7A8" modified="2016-11-02" version="1">MSFGRGAPRGRGGGGFGGRGGGGFGGRGGFQQRDMGPPATILEMGKFMHACEGEMICESINPKVPHFNAQIFLENKTAVGKVDEVLGPINQVYFTIKPSEGIQATSFKEGDKFYIGSEKLLPLEKFLPKPKPPPGAPKVKRAGRGGPARGGRGGRGGFGGRGGAPRGGRGGSGFGGRGGGGFGGRGGGGFGGRGGAPRGGGGFSGGRGRGGFSRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWA9</accession>
    <name>A0A1B7YWA9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164848.1">
        <property type="nucleotide sequence ID" value="XM_018296486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWA9"/>
    <dbReference type="GeneID" id="28860593"/>
    <dbReference type="KEGG" id="chig:CH63R_01511"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01511"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="711" mass="78696" checksum="AE4F665F50CD27B1" modified="2016-11-02" version="1">MKVKCSGSQPCARCDRKKHRCIFAAEDKRVSVPESYLRELQNQRRNSEQASDRSARAVSRADDAEDDVRGRYADAYATPHPTSLGPSEDAAAAGQLETPSNDSPRPGGPAASEPDTEVEDAPSALGEQSDFGPGFRQNPLVDNDYTFAKVGERYWYMGPTSSWSFCRRVLALLGKRIPEAAPDPWHLPHEGAFRMHWTPLGASEAPDVSNLPPLDYAMFLFNTAKFYLGAVFYLVDEPSFLREMRELYEDPAAKAASSRLWYAQYLLILAFGKAFVVSGGGPHATAPPGAQYAARAMALLPDLSGLNPDSILSIQALALAAVYFQCLDMRLAAYQHIGQALRIGIVEGIYRHMPEEVVGTEYSRRCNIVFWVVYTLDREFSALMGAPTSIRDEDITVKLPSKMDGSLDALNMTLHVRLSRLMARILTTVYGVGKEFDGSLVLNTQSILRDLARLSRDLTALLDTHFQGSVSRASRMALRLILSYHHCVVLTTRPLVMCALHMHIEHSDNRHSQTVSLTPPVASLLQSCVDSAQTVLRTLRVLGDEDLLEAFLPFQLEDAFSSAFLLYLIRVISPSLLQDDAWCDNIKCVLDRMIAKGSLVAPLRRLELSQLEHIMSALTPAGEEPPTPPPSTAQQQQQHHHQQHAQQHVQHGQHHGSHEHGSFLDQMEEAGWDIFDTSGMGGLSPQALLDLAERLDVEDLIQSVDGDGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW22</accession>
    <name>H1UW22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">SWIM zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04612</name>
        <name evidence="6" type="ORF">CH63R_09824</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000345">
        <property type="protein sequence ID" value="CCF32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154222.1">
        <property type="nucleotide sequence ID" value="XM_018304798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW22"/>
    <dbReference type="STRING" id="759273.H1UW22"/>
    <dbReference type="GeneID" id="28868905"/>
    <dbReference type="KEGG" id="chig:CH63R_09824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09824"/>
    <dbReference type="eggNOG" id="ENOG502RZA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037984_0_1_1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="309" mass="34767" checksum="DC4076F861551ED5" modified="2012-03-21" version="1">MGGFYPPAEATRPEPGGHKKAVQGSTTRASQIMPMASPSRKRKAISVDDQQQPESPEKPKKTKTATGATGEKRLRRFRPKPPQSFHDVYHRATTQRFYVLERRRCGTDDAPEEEVELTGSTGNVYTVHIGQVPSCSCPHSLKGNQCKHWLYVMSRVLRAKYEHTYQLALVPSELREIFTHAPPIDAPADGSQDKNRKPIDGDCPICFCEFEAESKETIVWCRAACGQNIHKECFETWAATKRRGGGGGDVTCPFCRSVWQGDEKMVKDIKKGGKVTREGYVNVADQLGISTQRDYSTYSRWWTRGQGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW99</accession>
    <name>H1UW99_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04668</name>
        <name evidence="8" type="ORF">CH63R_10813</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000368">
        <property type="protein sequence ID" value="CCF32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155211.1">
        <property type="nucleotide sequence ID" value="XM_018305787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW99"/>
    <dbReference type="STRING" id="759273.H1UW99"/>
    <dbReference type="GeneID" id="28869894"/>
    <dbReference type="KEGG" id="chig:CH63R_10813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10813"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_2_0_1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109582" checksum="6309ABEAA94C5F22" modified="2012-03-21" version="1">MQNQLAQDPASTPVGPVPLSFAQGPRIKSRYPTVTAAFYHHAETQPHVTAARDLSAQQIREITYGDLAARANQLSRKLTGLGVKPGDRVPLVVKRGIDMLVGIVAVLSCGAQYVPLDGGVVPDSTLRFVLEQAGGKHVLCLKSTKHRFETLGCSCETLVIDEDLGESEETSQARAYHDLAKPEHGCYVIYTSGTTGTPKGVDVTHKNVTNLVCLSPGDLGISTGTRVSQVLNISFDMAAWEILGCICNGGTLVLRGPKWEPCLREAQVLICTPSILAKYDPREYSNIKVAATAGEPSSQRLADLWATHATYYNCCGPTETTIVNTMHLHQPGETLTIGKPTPNNTVYVLDSDGKALGVGEPGVMWAGGHGISRGYVSLPEKTAERYKLDPFTKDGSMMYNTGDLGRWRQDGSIDILGRVDDQIKIKGFRVELDGVTASINTCPAVSKAATLFIHNEIHGFVTPRDCDLDAIQVHVRARQPYYAIPTKFHFLDALPLTSNGKVDKRALQDLVTVTENDKKEETSITIRETASKESLSTDSKSSVTDLNAESSASSFTEVDEKPDLGRDVPAKTLARPYRGFVHRIAIVYRRLFTIVGALNIAAVVALAFAGFQRTWLGNLTAINLLVAVLARQDFVINALYAVTCNVPKSWPLAVRKRCAKIFHFGGVHSGAAVSAGAWLLATNISDEVCQLAECPVWGYQSTASKVVSWMLTGLFTVTIALAWPAFRKTHHDLFEKTHRFVGWTMLGLFWVQIVLGANDGRAADMSLGAACIRTPGFWILIMATMSIASSWLFLKKVPVEAEVLSNHAVRLHFGYTVPVNGSFVRLSRRPLLEWHSFATIPAPERVEHRPKGFSLVVSNAGDWTKNCIEKPPTHIWVRGVPTCGVMRIATCFNRIVVIATGSGIGPLLGHIQDQSCPTQLIWSTPRPEQTFGKPLLDAIKSKIPNAVIHDTKTMGRPDLVKMGYNLAKSFQAEAVIIIANEKITKKVVYGLETRGVPAYGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWF4</accession>
    <name>H1UWF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04716</name>
        <name evidence="4" type="ORF">CH63R_02633</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000383">
        <property type="protein sequence ID" value="CCF32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162424.1">
        <property type="nucleotide sequence ID" value="XM_018297608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWF4"/>
    <dbReference type="GeneID" id="28861715"/>
    <dbReference type="KEGG" id="chig:CH63R_02633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02633"/>
    <dbReference type="eggNOG" id="ENOG502S73R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128832_1_0_1"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="128" mass="14321" checksum="2C888F97898D42B0" modified="2012-03-21" version="1">MSYLLYSVSFLLLVTATALYFTRAHWLPHLADLPIPGRDYIYSRLPSSFVGDVEAGLSSSTFDLAGNVESGDTRAGLDDRSKAEILKIMKKRRMKFDDARRAYMQQRFKANGIGPDGRPLDPKAVTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZU3</accession>
    <name>H1UZU3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05676</name>
        <name evidence="4" type="ORF">CH63R_09738</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000781">
        <property type="protein sequence ID" value="CCF33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154136.1">
        <property type="nucleotide sequence ID" value="XM_018304712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZU3"/>
    <dbReference type="STRING" id="759273.H1UZU3"/>
    <dbReference type="GeneID" id="28868819"/>
    <dbReference type="KEGG" id="chig:CH63R_09738"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09738"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446181_0_0_1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF6">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="599" mass="64723" checksum="372943EA00E5931E" modified="2012-03-21" version="1">MASRTLKVAAAQMGTTNYTDARSKTLDRMLALLDDAAAKGAQLVLFPETAFTTFFPRHLINDPVELDSFFEHGDIVTQPQTKPLFDKATERGTDIAVGFAEKTDDGETFNSCVYFHAKSGSILSKYRKIHLPGDFEPFADPNATNQLEKRYFKPGDLGFNAFRVPDLVPSSPERGDPIFGMMICNDRRWAESWRVLGLQGVEVVLCGYNTAGFAPHLWGSSADMDPDEARSKALFHHKLVMQAHSYTNACFSISAARCGLDDGKYDLIGGSCITGPEGELIAEASTTEDEVVYAEINLDACRPGKERTFDFARHRRVEHYSCITEQTGVVEPPKLGPQGRTLVNGVHGKKDKKIRVLLVNPNSTRAMTDACVSMVESQLPSDVIVTGFTAPRPSPSAIEGSFDNVMSAAAAARAVLPLAATHDAVLVACYSDHALIRMLREELPRQPVIGIMEASLFAARTLGGRFGLIAVSERSRVLHEDSIHHYGFSTSCAGVLSCGLGVLDLHEKSQDEVMGIMANVGKRLVEEKGADVLLLGCAGMTPLKPAVEAAVGDDVQVVDGVLAGVHHLVGLVRMGGATAKRGVYKSSAAGRKARGQDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1V372</accession>
    <name>H1V372_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06622</name>
        <name evidence="3" type="ORF">CH63R_06265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001232">
        <property type="protein sequence ID" value="CCF34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159090.1">
        <property type="nucleotide sequence ID" value="XM_018301240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V372"/>
    <dbReference type="STRING" id="759273.H1V372"/>
    <dbReference type="GeneID" id="28865347"/>
    <dbReference type="KEGG" id="chig:CH63R_06265"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06265"/>
    <dbReference type="HOGENOM" id="CLU_129980_0_0_1"/>
    <dbReference type="OrthoDB" id="5176208at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555514" description="SnoaL-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18310" checksum="F9107E9C4180795B" modified="2012-03-21" version="1">MKSSIFLSLGLLLGAAKAIDMREYAPECGVDRGFRIWYRELLASFEDATTTEGILDWFAPGGVMVLGDQGAAGDEILQARGAILPADGSVQWNHFPNTTIVSDETPTNKSFVVSGVLQLTNGTCATTYFQTLFTVEKDPTTGQADLESHGGRILVYHGFSINATTDPCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3L7</accession>
    <name>H1V3L7_COLHI</name>
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        <submittedName>
            <fullName evidence="8">Nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_06737</name>
        <name evidence="8" type="ORF">CH63R_06420</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001286">
        <property type="protein sequence ID" value="CCF34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159245.1">
        <property type="nucleotide sequence ID" value="XM_018301395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3L7"/>
    <dbReference type="STRING" id="759273.H1V3L7"/>
    <dbReference type="GeneID" id="28865502"/>
    <dbReference type="KEGG" id="chig:CH63R_06420"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06420"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:001278">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
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    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="32411" checksum="D470A6198096A4D0" modified="2012-03-21" version="1">MRPTLSRPFQYTLRVLGHENPLGLPKSGTPPNWPKKPVQRKIRGVEKVIAVSSAKGGVGKSTIAANLSLAFARLGYRAGILDTDIFGPSIPTLFNLSGEPRLSQNNQLVPMTNYGVKTMSMGYLVPEEDAVVWRGPMVMKAIQQLLHEVDWGALDILVLDLPPGTGDTQLTITQQLLLDGSIIVTTPHTLAVKDAVKGINMFNKVNVNILGLIQNMSLFNCPHCHGNTHVFGSNERVERMCRDHNISFLGDVPLHQSIGDNADLGKPTVAAEPTSERAEIFLKIARDIAPKIDLCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V584</accession>
    <name>H1V584_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07184</name>
        <name evidence="4" type="ORF">CH63R_04585</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001516">
        <property type="protein sequence ID" value="CCF35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160806.1">
        <property type="nucleotide sequence ID" value="XM_018299560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V584"/>
    <dbReference type="STRING" id="759273.H1V584"/>
    <dbReference type="GeneID" id="28863667"/>
    <dbReference type="KEGG" id="chig:CH63R_04585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04585"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021695_0_1_1"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="464" mass="51161" checksum="5FF543FCE56F32BA" modified="2012-03-21" version="1">MDEIAKEYDVIVLGTGLTECILSGVLSVKGKKVLHIDRNDHYGGEAASVNLETLFKKHGNYAQGEEPWAKYGRLNDWNIDLVPKFLMSAGELTNILVSTDVTRYLEFKQVAGSYVQQGQGSKATVAKVPSDAGEALRSPLMGIFEKRRMKSFIEWIGTFDRKDPGTHKGLDINRVTMKEVYDKFGLETGTRDFIGHAMALFTTDEYLTKPGAAPEAIERIRLYGTSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTNVDEVQYEGGKAVGIKATMTGVEEMKFETKAKMILGDPSYFPNKVKVVGQVVRAICILKHPLAGTNDADSSQLIIPQSQIGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETNANHHLELQPGLERLGKIEEQFMGAPIPIYEPTDDGVADNVFVSKSYDASSHFESTTDDVKDIYRRATGEELKVEGLREGLQVAGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V590</accession>
    <name>H1V590_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_07190</name>
        <name evidence="5" type="ORF">CH63R_11978</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001518">
        <property type="protein sequence ID" value="CCF35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153793.1">
        <property type="nucleotide sequence ID" value="XM_018306952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V590"/>
    <dbReference type="STRING" id="759273.H1V590"/>
    <dbReference type="GeneID" id="28871059"/>
    <dbReference type="KEGG" id="chig:CH63R_11978"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11978"/>
    <dbReference type="eggNOG" id="ENOG502RXC9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_4_1"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="33165" checksum="C924E3E3E70F9415" modified="2012-03-21" version="1">MSRAILITGATGKQGGAVVDALLSHGSSDLLLAVTRNANSPSARRLAAKSSSIKIVEGDLDAAPALFASAKAAAGAAPLWGVFSVQAMSDRKSDKETQQGKALVDEAIKAGVQHFVYSSVERGGDERSWNNPTPVPHFITKHRIEHHLRNSTANNKSPMGWTILRPVIFMDNLAPGFFGKVFLTMIHDIMGEKPLQWIATKDIGFFAAEAFRDPKTWNKRAIGLAGDNLTFSELSQTFKTVTGEPVGTTLGILGKALKHGVQELGIMVAWFKDEGYNADMAEIKRIHPGVMTMKHWLSDSAFVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7D4</accession>
    <name>H1V7D4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell division control protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_07770</name>
        <name evidence="13" type="ORF">CH63R_02778</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001849">
        <property type="protein sequence ID" value="CCF36136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162569.1">
        <property type="nucleotide sequence ID" value="XM_018297753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7D4"/>
    <dbReference type="SMR" id="H1V7D4"/>
    <dbReference type="STRING" id="759273.H1V7D4"/>
    <dbReference type="GeneID" id="28861860"/>
    <dbReference type="KEGG" id="chig:CH63R_02778"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02778"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF36136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR14052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="194" mass="21607" checksum="983FC5F4AD4E8CA4" modified="2012-03-21" version="1">MVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLREDPSVREKLSKQKMSPVRKEDGERMAKDLGAVKYVECSALTQYKLKDVFDEAIVAALEPPAPKKKSHKCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1V835</accession>
    <name>H1V835_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">R3H domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_01485</name>
        <name evidence="18" type="ORF">CH63R_10931</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001957">
        <property type="protein sequence ID" value="CCF36387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155329.1">
        <property type="nucleotide sequence ID" value="XM_018305905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V835"/>
    <dbReference type="STRING" id="759273.H1V835"/>
    <dbReference type="GeneID" id="28870012"/>
    <dbReference type="KEGG" id="chig:CH63R_10931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10931"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022096_2_0_1"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="163"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="299"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="246"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="464"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="521"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF36387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR06811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="597" mass="64686" checksum="2325CDFA4F082F08" modified="2012-03-21" version="1">MSQQQHDMYLDYSAPANRSPSSSRGYAGGFQSGLSLPRQAQRPYDNGLGSSALFPSDRLGYNPRAMDQMSANGMPGGYMLDNSQAWNYNAGGVATVNGAMNGANRQRSVNRRAALPTNWTDQGLGMHSSYGPGLNNGMSNGLRYDGQGDMRPSSQTEEQLIPTAIVIKNIPFAVRKETLAAVMLEMHLPQPYAFNYHFDNGVFRGLAFANFQSPEDTKIVIDAMNGMEVHGRKLRVEYKKMLPEAERERIEREKRERRGQLEEQHRAPMLHQQPSLQTLNSVSSNPPRGPLEGDIDLNDPETLEFYTELTLFKRDTSREILIFPSTVAPEQRRRIHILAHHMGLEHNSVGEAESRQIHVVKRQLPSPTAQIHSPAVGLDYHKKGLSRAATFDFTADREARSASTNYSHAIGRQGPTLELPGSPDGNGLANLRAAKSFADLRSFSPSPSASSSSYLTAMNGIGNIPQSGNSNPRFGDYNGGVNQTGQLATPNLTPTSGTVGTPGTDSSLLSSLGGLNLGSYESAAHSQARSTPGAIGSQRPGANSGNRNAPERQPRGPEWETSAGFSGRNRSNGHMQRGSDSSDNAPRAGSAGASRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8M0</accession>
    <name>H1V8M0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08112</name>
        <name evidence="4" type="ORF">CH63R_03924</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002043">
        <property type="protein sequence ID" value="CCF36573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160145.1">
        <property type="nucleotide sequence ID" value="XM_018298899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8M0"/>
    <dbReference type="STRING" id="759273.H1V8M0"/>
    <dbReference type="GeneID" id="28863006"/>
    <dbReference type="KEGG" id="chig:CH63R_03924"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03924"/>
    <dbReference type="eggNOG" id="KOG0382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039326_4_0_1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF274">
        <property type="entry name" value="ALPHA-CARBONIC ANHYDRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497619" evidence="1">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="272" mass="30322" checksum="BE937679615295F4" modified="2012-03-21" version="1">MIAELFFGVLLLATNALACASHENHYNLADRKRDAEEAGPKTDWAYEASFNWGRINPNYTLCQTGTQQSPIALSLNNGLALNHILRFNYPNQTAGNFFNWGYGPAFTLTHPEGVYTGNPSFTYDNTTLYLKGWHIHSPADHSVNGARSKAELHLVHGDDQGRERAVLAILLNPGNANSTFFDQLPPMIGFNDVGTEVPVTLDLGKALNSVQLFNEFWTYQGSLTSPPCTEGIRWFVARQQLFTGVEQMRAILGASTYSARAEQEVWQHRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8T6</accession>
    <name>H1V8T6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BZIP transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_08162</name>
        <name evidence="9" type="ORF">CH63R_06633</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02002071">
        <property type="protein sequence ID" value="CCF36639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159458.1">
        <property type="nucleotide sequence ID" value="XM_018301608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8T6"/>
    <dbReference type="STRING" id="759273.H1V8T6"/>
    <dbReference type="GeneID" id="28865715"/>
    <dbReference type="KEGG" id="chig:CH63R_06633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06633"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_897182_0_0_1"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF36639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="310" mass="34339" checksum="16DD54A5731862C7" modified="2012-03-21" version="1">MNTPPSFFSDAVDVATPTNDEFPSDHPRKLDPDSFHFTPPEDIDSPPGIMSQDPSAYMTVSSAWGPLVPNPLSLYGHNYHSQYATKQEDIDDRPVLSIVPSVSTSQSSVRADSSISMQTQTSKSSRTTDPADASPPRKKGRKSKAPAQGENDGKRDKFLERNRVAASKCRQKKKEWVSDLQETKQGLENQHAQLQMEYNGLVNEVTRMKNELMSHANCNDPNINLWLENEARRFVQISADRVKKQSLDASRAVGDRPLGMGGSYMPSIDSQMSLISPSHSERAMTTMSSRSGSSADINYDHMPDSAFEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCY9</accession>
    <name>H1VCY9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TfdA family Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09270</name>
        <name evidence="4" type="ORF">CH63R_10568</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002798">
        <property type="protein sequence ID" value="CCF38092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154966.1">
        <property type="nucleotide sequence ID" value="XM_018305542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCY9"/>
    <dbReference type="STRING" id="759273.H1VCY9"/>
    <dbReference type="GeneID" id="28869649"/>
    <dbReference type="KEGG" id="chig:CH63R_10568"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10568"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="106"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF38092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="415" mass="47284" checksum="4FD9BBDDDEFF2909" modified="2012-03-21" version="1">MSTTTTTSTVTWVTPAAKQPPGQPEINYAPDYDKWQARVARRLSQGNLHTKLPDGFPSQLTGPMVWEGETLAETYDWTYVLNAEQLAEVDRAVAHFQSLHLSYGHINVETFPLPTLHSVLRRLSHELHSGHGFFDLRGIKVEEHTREENIIIYAGLSAHVAAQRGRQDHKYNGEPADVVLTHVKDLSHADPNNIIGSPAYTTDKQVFHTDSGDIVALFALETAKEGGASKLTSTWRVYNEIARTRPDLIHTLSEPWDMEVFEKADKQWTERPLLYLLPATETAPQRVSLQYGRRYFVGFGALPRSSEIPPITEAQAEALDTLHFTGERFCVNTEFEKGDIQYVNNLSLFHARDGFVNQDEKQRHLLRLWLRDPENAWATPEVLQTRWDQIYKDVRPETEVFTLEPYIRSSANKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFM8</accession>
    <name>H1VFM8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09979</name>
        <name evidence="3" type="ORF">CH63R_06433</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Sykes S."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <sequence length="114" mass="12453" checksum="5DE8BAD6C930A0A7" modified="2012-03-21" version="1">MNTPGSFGIVDYSFPMWSKKHVGSWLDAFKPRRSSTSSSSTSSSRTSSFSTSSRSGPSSRNGSLASLMSMGTVEEQEHLMAEQPKRPAYVPQHAAKSFMKTATSKEIRKNGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKH3</accession>
    <name>H1VKH3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_02418</name>
        <name evidence="9" type="ORF">CH63R_13869</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004257">
        <property type="protein sequence ID" value="CCF40726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151161.1">
        <property type="nucleotide sequence ID" value="XM_018308843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKH3"/>
    <dbReference type="STRING" id="759273.H1VKH3"/>
    <dbReference type="GeneID" id="28872950"/>
    <dbReference type="KEGG" id="chig:CH63R_13869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13869"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024939_0_0_1"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF40726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="599" mass="64580" checksum="E2FB41A0085961F2" modified="2012-03-21" version="1">MSSMEKDVEKAEVEVAKPKESHAAPEQTARRISLTKPPPTPPKDDGYRPMTSSTKRLSFSTTMSPRRIKYGTGKHSKTELSPQPTDDPDDPLNWPQWKKELNYVALMMTVGLIGGMKTAYVSVNGVLAVRFNTSYTAVASLTAVPLVVSAFTGLLGLMVAKVYGKRPVYLVSMALVFIGAMWNMRAGNSFGECMGARVFQGLGWGAFDSLVLGSIQDTYFEHERNVRITAYNLLSVATTWGAPLLGGLASRNAARFTIQFEVINALQIVAVPLLVFGAPETSFERWFSFSMAQTPASSVSWTSKYPKPLGKPSVENVKAYLRTMKPFSFSVDPDLATLLQAPRAFVAPTTLLLVVVTFMPYCALWGLTESLSLLFSPMPWMLNESAIGSLMAAPFVFAVVTVCGLGFYRKRPADHTPYDTVSILAAGTALAAAGILAFGLETYGVMSASGASGTADAFKMDGVGLRLSFPLLSFLLGLLAAGVAVLDGAVRPVIWRSTQFTSSNMGVCLRNVADMHAGVACWRNLLAGVFVMVLPNAVVVWAGLKAIVVGLGVTQILVGAGMCGAWWFYDDYVRGLDGRVMGLVDLSMLRRAGSFFDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL10</accession>
    <name>H1VL10_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_02461</name>
        <name evidence="15" type="ORF">CH63R_12672</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004379">
        <property type="protein sequence ID" value="CCF40913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152063.1">
        <property type="nucleotide sequence ID" value="XM_018307646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL10"/>
    <dbReference type="STRING" id="759273.H1VL10"/>
    <dbReference type="GeneID" id="28871753"/>
    <dbReference type="KEGG" id="chig:CH63R_12672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12672"/>
    <dbReference type="eggNOG" id="KOG2583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_0_1_1"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF40913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR03545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="456" mass="47354" checksum="6D692DCB9442FEE2" modified="2012-03-21" version="1">MISRPSLTRPAQQALRHSSCARTISGRRFASAAAGSGAFETSDVGGVKVAARDSQGPTTKLAIVAKAGTRYQPLPGLAVGLESFAFKNTSKRSGLRIVRESELLGSQLTAYHTREALVLEASFFRDDLPYFTELLAEVVSQTKYTTHEFHEEVQPVLRLKQSATSAAALALDSAHSVAFHSGLGSPANLTPSIPIQPYLSEFAVSEFAQAAYAKPNIALVADGASAANVSKWAEQFFKSVPSASSGKLALNTAATKYYGGEQRTYSPSGNSLVIAFPGATNGQTSPELAVLAALLGGKSSIKWSPGFSLINKAVGSAPGLSTSTVNLSYSDAGLLSVQFSGPASAIRTAAQEAVKALKSISEGTVSKEDLTKAIAKAKFDALEATEKRSGSILLAGSGLVHNGKPINAAEVANSIGSVTAEKLKTATKTILEGKASVAAVGDLYALPYAEELGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VML4</accession>
    <name>H1VML4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11731</name>
        <name evidence="3" type="ORF">CH63R_11616</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004714">
        <property type="protein sequence ID" value="CCF41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153431.1">
        <property type="nucleotide sequence ID" value="XM_018306590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VML4"/>
    <dbReference type="GeneID" id="28870697"/>
    <dbReference type="KEGG" id="chig:CH63R_11616"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11616"/>
    <dbReference type="eggNOG" id="ENOG502SUJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1928318_0_0_1"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="145" mass="16404" checksum="A3EDA7F5242BDA2D" modified="2012-03-21" version="1">MTIDINASEFRLSGEKKTFQAQIIDDGYQHSLVVYQDIATQSFRLHAMVRDGVLRQCPVWTAFVTHQSASPTWLQRKGRKRVWLKDVHLYVFCQEYRQQNQRKGEAGAFEINFVSESGAAHFPEAFLSAASGPSTGSHQAIEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNS0</accession>
    <name>H1VNS0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_12021</name>
        <name evidence="8" type="ORF">CH63R_08829</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004996">
        <property type="protein sequence ID" value="CCF41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155826.1">
        <property type="nucleotide sequence ID" value="XM_018303803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNS0"/>
    <dbReference type="GeneID" id="28867910"/>
    <dbReference type="KEGG" id="chig:CH63R_08829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08829"/>
    <dbReference type="eggNOG" id="KOG4831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108086_3_0_1"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="154" mass="17044" checksum="1005941C00D432CC" modified="2012-03-21" version="1">MTSPDATPEPQPAAINYVAGFLLVGLAWGFTTPFIRRAAKDHNPPPHPVLESDAVRRSWLRSRIYGAFFGVLDLLRNPRYAVPLLINLTGSVWFFLLIGQAELSLTVPIVNTLAFLFTVIGDWWVESKVISRQTLVGMVLSLSGIALCVHSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPY2</accession>
    <name>H1VPY2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alcohol dehydrogenase GroES-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_02792</name>
        <name evidence="11" type="ORF">CH63R_07875</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005279">
        <property type="protein sequence ID" value="CCF42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157627.1">
        <property type="nucleotide sequence ID" value="XM_018302849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPY2"/>
    <dbReference type="STRING" id="759273.H1VPY2"/>
    <dbReference type="GeneID" id="28866956"/>
    <dbReference type="KEGG" id="chig:CH63R_07875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07875"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF7">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="420" mass="44561" checksum="634A6103F68E35C1" modified="2012-03-21" version="1">MAPVATGEMAPMHLPVYKSKSSSVTASVLHGPRDLRLETRSIQEPSVGELQISVKRTGICGSDVSYYKKFANGDLCACHPLSLGHESSGEVVAIGPQVTGFKLGDRVALEVGVPCGQCTICRKGRYNLCKKMRFRSSAKSVPHYQGTLQERINHPAAWCHKIPDHVSYEAAALLEPLSVAIHAVNRAKPEPGSTALVIGAGTVGLLTAAMARQAGCAQVTITDVDAGRVEYAVEKGFATHGHVVNSNSGTSTPADPGVMTPASIFSVQSVQGKFEGAKSLAAEILALTKVPEEVDMDCEDDGVDVTFECTGKEVCMQTSLYATRPGGKVVMVGMGTPVQTLPLSVAHLREIDILGIFRYANTYPTGVRLLCAKGNGGLPCLDDMVTHRFKGLHNASKAFELASRTCDDEGKLVLKVVIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRY1</accession>
    <name>H1VRY1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_02966</name>
        <name evidence="2" type="ORF">CH63R_01084</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005789">
        <property type="protein sequence ID" value="CCF42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164421.1">
        <property type="nucleotide sequence ID" value="XM_018296059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VRY1"/>
    <dbReference type="STRING" id="759273.H1VRY1"/>
    <dbReference type="GeneID" id="28860166"/>
    <dbReference type="KEGG" id="chig:CH63R_01084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01084"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075862_1_0_1"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26232" checksum="3FD1F893693D0096" modified="2012-03-21" version="1">MGSLGETSALPYWQVNVPPESRTDECPEGLRNLSAKDVGILRTPDGAYRPQTWDEVRRLVATNRLDLFQRVPSELRRYRLFIHHLIKEHGSVMNFVLGHRLGWQEPLVARGKPFETEADWKVLYNDWPYGIDERIVHLVVWTKFELEEDAATGDLTEGARGEIEAFVDKTFRASTGPDTVIWFKNWRSLKSVHAVEHFHVMLFDPDPEFIREVTNRDVPQCDKFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VTE2</accession>
    <name>H1VTE2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_13183</name>
        <name evidence="12" type="ORF">CH63R_01008</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006151">
        <property type="protein sequence ID" value="CCF43500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164345.1">
        <property type="nucleotide sequence ID" value="XM_018295983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTE2"/>
    <dbReference type="STRING" id="759273.H1VTE2"/>
    <dbReference type="GeneID" id="28860090"/>
    <dbReference type="KEGG" id="chig:CH63R_01008"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01008"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF43500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="508" mass="55069" checksum="231126B3EA36EAFE" modified="2012-03-21" version="1">MSYTHTGAPTEFNGTNADFGGDSTTTNLNQWYQSGDQSYILVSAAMVLLMIPGIAFLYSGLARRKSALSQLWVVMMSFSVVVFQWYFWGYSLAFSETATNGFIGDLRHFGLMKVLATPSQGSPLVPALLYSFYQMMFCAVTAALTAGATAERGRVIPCMVFIFFWATLVYAPLACWAWNANGWAFKYGVIDYAGGGPVEIGSGMSALAYSWVLGRRNEKMMLNFRPHNISLITLGTILLWFGWLGFNGGSAFGANLRAAMACWNSCLTAMFAAMTWCLLDFRLAKKWSLVGWCSGTISGLVAATPASGVISPWASIILGVVAGVACNFGTKIKFLLKIDDSLDVFAEHGIGGIVGLIFNAFFASGSIIGLDGVNTGLTGGWVDGNYKLMYIQIAYIVACSAYTFVMSALIAKIIDMIPGLKLRASEEAELLGMDDDQHGEFSYDYVEVRRDFLAWTPHQAEPAGEGRFIPQHGIEEHQNMANGGSSGSDEPKPVTPQGEPRSEKVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VUT9</accession>
    <name>H1VUT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_03234</name>
        <name evidence="6" type="ORF">CH63R_10653</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006545">
        <property type="protein sequence ID" value="CCF43998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155051.1">
        <property type="nucleotide sequence ID" value="XM_018305627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUT9"/>
    <dbReference type="STRING" id="759273.H1VUT9"/>
    <dbReference type="GeneID" id="28869734"/>
    <dbReference type="KEGG" id="chig:CH63R_10653"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10653"/>
    <dbReference type="eggNOG" id="ENOG502SPW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_0_2_1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF43998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="263" mass="29221" checksum="9902AB26EB332AF0" modified="2012-03-21" version="1">MGVTKPQLTTPPSAPRALLCIHGSGGSANIFRVQTAKLRMALRHEFEFVYATAPFESEPGPGVLPLFRGMGPYRSWFLKDDGDKNTRVNRANDEEMPSAETSSVGGRLLAVNKPVQKVVEDWQKNNPQIPIVGVIAFSEGALVAALLIWQQQMGRLPWFPKMDVAMFICCYYTEEATDYIKTESPGDQKSILIDVPSVHLQGLQDFALQGSRKLAATHFSPQNADILEFQGGHHIPSRKSDIDEAARRFLNLYKNRKPKALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VV30</accession>
    <name>H1VV30_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_03236</name>
        <name evidence="13" type="ORF">CH63R_02553</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CACQ02006612">
        <property type="protein sequence ID" value="CCF44089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162344.1">
        <property type="nucleotide sequence ID" value="XM_018297528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VV30"/>
    <dbReference type="STRING" id="759273.H1VV30"/>
    <dbReference type="GeneID" id="28861635"/>
    <dbReference type="KEGG" id="chig:CH63R_02553"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02553"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="118"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF44089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="476" mass="53421" checksum="BFDE1E87ABBDFFC2" modified="2012-03-21" version="1">MASNAKSRWADSEEDAALEAKLKREKEEKKRLKAEKARVAEAERLAQQTRASIDNGSMSGNDGNGDSRPAKRRKFAPDADSGREPATADDALDKKEGAARLMRFPFGRWGKCRSVENYDKLNDIEEGTYGWVSRAKETASGKVVALKRLKIEPSDRNGLPVTGLREIQILRDSSHRNIVNLEEVVVGDDTSKIENIFLVLEFVEHDLKSILEDMPEPFLLSEVKTLLRQLTAGVAYLHDNWVLHRDLKTSNLLLNNRGQLKIADFGMARYVGDPPPKLTQLVVTLWYRSPELLLGARAYGRAVDMWSVGCIFGELLTREPLLQGTNEVDQVTKIFELCGVPTQESWPSFRSLPNARSLRFPKTSLVTGSVIRTKFTTLTNAGCALLNDLLSLNPDSRPSAKEMLEHKYFREDPKPKKEGMFPTFPSKAGQERRRRHEPNAPIRGQNAVELGDVDFSGIFQGRDKEERGGGFSLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VW77</accession>
    <name>H1VW77_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_03344</name>
        <name evidence="13" type="ORF">CH63R_04489</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02006935">
        <property type="protein sequence ID" value="CCF44488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018299464.1"/>
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    <dbReference type="STRING" id="759273.H1VW77"/>
    <dbReference type="GeneID" id="28863571"/>
    <dbReference type="KEGG" id="chig:CH63R_04489"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04489"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF44488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="249" mass="27647" checksum="CE5146E8AA7505FC" modified="2012-03-21" version="1">MASQDSKPASNSGPTQCVGPLYRSESQKPTATVSTEVNSDNVIVLPQTPQLIALLTIIRDRNTERGDFIFYSNRIIRLLVEEGLNHLPTVEHDVTTPIGRTYSGLMFQGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETAQPKLFYDKLPEDIAQRWVLLLDPMFATGGSAIMAVQVLKARGVPEDRILFLNLIASPEGIQNFTAKFPKLRVVTAFVDQGLDEKNYIIPGLGDFGDRFYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWX7</accession>
    <name>H1VWX7_COLHI</name>
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        <recommendedName>
            <fullName evidence="12">Autophagy-related protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_03415</name>
        <name evidence="9" type="ORF">CH63R_11787</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007135">
        <property type="protein sequence ID" value="CCF44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153602.1">
        <property type="nucleotide sequence ID" value="XM_018306761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VWX7"/>
    <dbReference type="STRING" id="759273.H1VWX7"/>
    <dbReference type="GeneID" id="28870868"/>
    <dbReference type="KEGG" id="chig:CH63R_11787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11787"/>
    <dbReference type="eggNOG" id="ENOG502S77Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065432_0_0_1"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="37957" checksum="E45B7188DAE736D5" modified="2012-03-21" version="1">MANQIAPKETRTAPLFSAIPAQAASGKAGTSEASINPAKSPTPRLVLLPSRFPTPNWPSSSHWSDQVQQRAPPSLPFVSDGRPRLNQHPSQAVSFRNLDSPSCPSHHRAFNKTFHTQSFRTIPAAMASKGVSLLKFVGTVSLGLLTGLSYSLSTVTVPSILSLPSASDALRAFKNLYPGATARLRILTGVSATSFLLAFFLSPRAFRHPYLVYSSVLCLTSGLAEQITPYILKSSSESSKQSIAARRQASREREEARKAARLARQEARMEASYEVLGDAHSDGAGSASGDEAAAAAAIEEEEALNGEEVRGEVESFRKTQLVQSAVASFGFLLSVVGIWGDGAIQVFQSETAIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5C6</accession>
    <name>H1W5C6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04245</name>
        <name evidence="4" type="ORF">CH63R_00495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02010023">
        <property type="protein sequence ID" value="CCF47690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163832.1">
        <property type="nucleotide sequence ID" value="XM_018295470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5C6"/>
    <dbReference type="STRING" id="759273.H1W5C6"/>
    <dbReference type="GeneID" id="28859577"/>
    <dbReference type="KEGG" id="chig:CH63R_00495"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00495"/>
    <dbReference type="eggNOG" id="KOG0427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_15_0_1"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="155" mass="17903" checksum="F69E5CA999B1F740" modified="2012-03-21" version="1">MASSFASKRLAKELSKLNTDLPPGIDLISADNFEEWFMDIRVLDDNPLYKDQVYRLKFKFSQQYPIEPPEVTFVKTTERPIPMHPHIYSNGIICLDLLGSQGWSPVQNVESVCMSIQSMLTGNEKNERPAGDDEFVKSNRLRPRDIDFYYHDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQL1</accession>
    <name>A0A1B7XQL1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150565.1">
        <property type="nucleotide sequence ID" value="XM_018309593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQL1"/>
    <dbReference type="GeneID" id="28873700"/>
    <dbReference type="KEGG" id="chig:CH63R_14619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14619"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="123" mass="13491" checksum="1F59C3434F048511" modified="2016-11-02" version="1">MVSPTALPMKPSSPLSRAPSILRLDIARRLIHPTDLTTFLPPEKDSILVPAAFKGHLNLLQRLADQVPLLSPAFDMACGILLSNQFVVAWRCSSGSHPIPHHRDPFTGGVTIKDLWASRVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQU4</accession>
    <name>A0A1B7XQU4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150647.1">
        <property type="nucleotide sequence ID" value="XM_018309404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQU4"/>
    <dbReference type="GeneID" id="28873511"/>
    <dbReference type="KEGG" id="chig:CH63R_14430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14430"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="144" mass="16159" checksum="392E1E2E3E57EFA1" modified="2016-11-02" version="1">MLERLANPLVSKMGLWSNLHTGDQLEERAHGAILGHTTGIGKTRQMFLVIAVLRLIYLCNLDVQENPHRHITSIYTGPRDCPSEWKFGIRCVCNRNGLSSRLIATPLVSQQHNFPHVFITGANLVGQALRDANAFPRRDYITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQZ7</accession>
    <name>A0A1B7XQZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_14484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150701.1">
        <property type="nucleotide sequence ID" value="XM_018309458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQZ7"/>
    <dbReference type="GeneID" id="28873565"/>
    <dbReference type="KEGG" id="chig:CH63R_14484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14484"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="544"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="585" mass="65588" checksum="35BE3806DA7C38BA" modified="2016-11-02" version="1">MEDNLKRPRPQHFSDLDDRPRKRQATPDAVPRNDGWAFRRTIEPGARSELHGTGIRHSGSGSFSARDIYFGPTSDSDREFLKDLYVTDPRDDKARIERTKGGLLRDSYRWILDHDDFRRWRDDGQSRLLWIKGDPGKGKTMLLCGIVNELEKMSADTHILSYFFCQATEVRLNDSVTRDAVQQHLTSNANATFLWVALVCQELADPKVRKWHTRARLHTFPPGLDPLYARMMRIVADSLVSVVYRPLSLTELASLAESLEDFEDDADSLKEIIATCGSLPTVREEVVYFVHQSAKDFLLKNESKRIYPCGVTQENRNVALRSLKVMSGMLRRDIYNLRAPGFPINQVGPRDPDPIASARYSCVYWVSHLAAGNPAGQERSSQDLQDGGPVHAFLVKHYLHWLEALSLLGSMSEGILQMSTLAHLVQVSAEMLTLTKLSRDALRFIRTHRASIESNPLQTYASALVFSPMRSITRELFHQEEPRWIVTKPSMEDEWNACLQTLEGHNSPVASVAFSGDGTQLASASYDNTVKVWDGATGQCFRTLEGHSGSVWAVTFSGDSTRLASASDDNTVKIGDSATGQCPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRV1</accession>
    <name>A0A1B7XRV1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_13721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151013.1">
        <property type="nucleotide sequence ID" value="XM_018308695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRV1"/>
    <dbReference type="GeneID" id="28872802"/>
    <dbReference type="KEGG" id="chig:CH63R_13721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13721"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR02495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="276" mass="31315" checksum="AAE0DC195DC12A1B" modified="2016-11-02" version="1">MSFSRTLFAHSNEFNWIGDKHSSRFYERTRPDEPAGRVSCGEIRTQSTISTTRPQLNHTHTHTNPNGKKSAKMLLAEEPATLIRHTIDNFNIHPDKQAVARINESLATLQQARELRLREAENALKKLSRQLNTMASQHAELTSQHSSTAHASEIARLDTTKFRTAKAASDAEMEAERLAQQAADLSVRLQELEIQGLDGSADDQARRRDPVDDEVLLRLKVYRSLGIEIERDGRDGGGGEFTRAVVRNDRKGDVHVVNMDKKFSKFFYANYFWQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRV7</accession>
    <name>A0A1B7XRV7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150998.1">
        <property type="nucleotide sequence ID" value="XM_018308680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRV7"/>
    <dbReference type="GeneID" id="28872787"/>
    <dbReference type="KEGG" id="chig:CH63R_13706"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13706"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="472"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="675" mass="69139" checksum="4390E7F8B2AD19B2" modified="2016-11-02" version="1">MAHHNHGHRHLPRNPDFWDDVGNTFKGLNPFASDDESDSGSNRGKLKIRQDDDDDKPTPTPPANTRKGRSTVIKTIYQTVTDGDIRPAASSSTRLLVAESPLPTRTRSSSSDSSETTIARAGAPVIKTPETSTATSTDDSLSSSLPSVIEEPLSESIPTTLAIATDTPTFVRTTKPTVSGDGTGARVGASVISSASPSSTSTADESASAEPSGAAKAGIAIGVLAGVLVVFLLVFFLFNRRKKQLEQQRLADEDEKSGGFGTAAAATSQNPRAPRISLRPVTQFLPNLNIDKRASRGPAATMNANLAPAAAALGIRNPSQGSWDRPTTSQSANPANPFGAQAERINGPIAEESVSSLSLNEKPLPSVHVHETAPAPAANEPSGAVNGAAIAAGAAVAASAGAVAAGGLTRKASTRKDGPKALDLTLAAPPAPLSTVPASPSGTAFSADSAGPGHQSSSSTGSAAIAAAGGPANTTVHRVQLDFKPSLEDEMELRAGQLVRLLHEYDDGWALCIRLDRSQQGVVPRTCLSTRPVKPRPPQAQGPPRGPPMGPGASRGPGPNFPPGQRPMTPQGGPHGGPPYPRSESPARPMGPGGRTQSPGPRYQGPPGQRPQSPSGMGGRKPSPPGPSRIPQPSRMNPSGPPNGPQNGPQVPPAQGRPGPPMGPVGRKPVPGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRY7</accession>
    <name>A0A1B7XRY7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotrophy-associated secreted protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151039.1">
        <property type="nucleotide sequence ID" value="XM_018308721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRY7"/>
    <dbReference type="GeneID" id="28872828"/>
    <dbReference type="KEGG" id="chig:CH63R_13747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13747"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600980" evidence="2">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="24780" checksum="BAF193E1908ECE7F" modified="2016-11-02" version="1">MVRFFLTAAFLAAAALAIPNPLTPDPAGTKNIGNGHGVQFIGGACLSSRDCASACCAILSGAGICSGVGAQFQAGKQGCGFGDGIGAAPAPAPGRAKPSMEAAPDNGKSGSPGAPGSSNVGAGNGLQFITGQCLSDADCASGCCAGPKGACAARAVAEENGKSGCEFGGGASPATGSPGRPAVEDAAPSAPPQAAPPVNGGSSGVNQGAAGSQNVGKGNGQQFITGQCLSDADCASGCCAGPKGACSAVAVANENGKTGCGFIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTF7</accession>
    <name>A0A1B7XTF7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_14273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151565.1">
        <property type="nucleotide sequence ID" value="XM_018309247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTF7"/>
    <dbReference type="GeneID" id="28873354"/>
    <dbReference type="KEGG" id="chig:CH63R_14273"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14273"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="592" mass="62007" checksum="8A7950BBD4D60C6D" modified="2016-11-02" version="1">MLQQAPSGGPLEPGTLKTADTSTDCTEPTDPTGLTDLSEDARPSSTMETKESVAAAPARGLRFWAIVAALAASKLMLALEITIVSTALPTIVHTLGMGSSYVWVSNGAALASAAIAPPLGQLSDLFGRRHPTCLSVLLFVIGGIISGAAASGPQLIAGRVVQGLGAGGINVMSAIVVSDLVSVRHRGKYMAVMLTAYLLGAVSGPLLGGVLVQAGAWRWVFWLPVPFGVVSFLVLAFFLKGKVRDADSSRRERLRRVDYGGNVVLTAATGSMLYAVTYGGSEYLWSDARIIASLTAGVLGLGLFLLLERHLSRRSSSNNAVEPVMPLRLLNHREGATVAAGAFASSLLSNWANFLLPVYFQGVRMSTPSRAGVQLLPIVAVAVPASIVSVVLVSKLGRYKVLHVAGFAGMCVACGLFSILDAASGDEEWILMEVLFSLGLGMVINTLLPAFQGAVGESDQAVATSTFTFVQSLANIWSVTMPASIFNNRFGALAGRISDEQVRAQLGGGRAYGFATRAFLEGLQEKARVEVVDVFGEAVSGVWYVAAGIAGVAALLACAEGEVVLREKLETDFALEEKVGGEVKVDERSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTU6</accession>
    <name>A0A1B7XTU6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151709.1">
        <property type="nucleotide sequence ID" value="XM_018307292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTU6"/>
    <dbReference type="GeneID" id="28871399"/>
    <dbReference type="KEGG" id="chig:CH63R_12318"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12318"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601060" evidence="3">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="283" mass="31407" checksum="E558D5A2E87E390E" modified="2016-11-02" version="1">MKASHTQARRLVLLASLAYGRPTCIPASPVTTTTTTKPATTTRPSTTITSTRSAQSSLCTLYAYASVNGYDLLNNLWGQDDADSGSQCTYYYGPASSGGLSWGTTWTWKGAPNNVKSYAYANRQFTRRLLNSIKGLPTTAQWSYSKADIRANVAYDFFTHPDPNHPNYNGEYEVMIWLNKYGDIWPITESPSGTPIAQVQLAGYTWDLYFGYNEAMKVFSFLSASGPIYNFSADAMVFFNHLASNYAFPLSNQYLLIDQFGTEAFTGQDATFYVSRFQAEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUJ3</accession>
    <name>A0A1B7XUJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylation protein Rxt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151953.1">
        <property type="nucleotide sequence ID" value="XM_018307536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUJ3"/>
    <dbReference type="GeneID" id="28871643"/>
    <dbReference type="KEGG" id="chig:CH63R_12562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12562"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052793">
        <property type="entry name" value="EJC-associated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46589:SF1">
        <property type="entry name" value="APOPTOTIC CHROMATIN CONDENSATION INDUCER IN THE NUCLEUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1202" mass="132516" checksum="B07DFD53926483B2" modified="2016-11-02" version="1">MDPRQQQQQHQQQPQPQSQQQQHQQQQQQQPPPQLPFSRNAASQYSRSPFPPSSNTTANSTPNQSPFHAEHQRRSSENPYYPSGPRSYPPEPNNPGPVPPPSGHSGHSRHPSASSLPPAAPLNRNMPPPGSPPQPGNQPPPPPSSHQMTHYGLPAPRAPPLNVGHPTSFPGGRELPSLNSIQRTGSTGSSMSISSMLGGPPPSRDSQPPPSHYHPPATSAPSGPTFAPSMQASPRMHSASSEYQPFRRPQTPDHARPYDPRGSAAASPQGTYSTTPEMQRYGTPQQGYHQRGPSAQDGREPSRMSQGPPPPRPTSQPKSFQQNMPPRPAEMGRGNAPDDMYQRRDEIPRGSMEYNPERPGLKPMNFGDRYRAERERREEMEFRERERRERAYSGGDGGRNLPAHQSEYRPQDLQRAQPPPFTRPPEQRDQGPWPPRQQQQQQQQQQPQPQQQQPHHQQQQQQPFDQSRVPYDPAGLHPRHHHEHPPTSAPNYPGQGQNQSHPASASQYQQQPPPPNDRYSGPPNHPQQPPPGQPGQPQQQQQQQQSFDSPERQRVNHLHPQQVQPPPAHRRPTEDGPPPPSVAYNTPHGPPVYGSPRHRPAEEHPNINQRNLLAVQEMNRKGRVSPLPQAVQGAQPQLPGPAGEPGIKSEFGRMFSGIGSGVTGLGVGSPVTAGAQLPYTNASLARRDETDSAAHESGPDTTAPKPKGRRRKLKEEDTKGDEDSTGRLTPSGRAKRPKTHQHHHHQYVPVPSGLSTTTNGSSHHHHHHHHGADHAHAPTPAPVGVTPFKNVKGNTPIPSPTTGLTKDLPTAHHHHVPRPAPQHTHVREAPTKQAVQSPTSILPPKPKTIVSSKAVLESVAHRPRTHLGDVLYEPKLTPARQIPNVPSGRGFSSTPTPLPWHIIKDKENCTLTVKVPKVHLTPLAREEITARRALWGTDVYTDDSDIIAACIHGGWIRGEWAEDVDVALLDLDRGLSAPEKEVPATKRRKEKEKEEKARLEANSATYLDKPPKTGPVSVPADRDMHVSIVILPRLEKYSSTTRFGIQSREYGGRYNGRQSIHDGISFMITGIRWVTNGAGTQNRLRGKGRRERMRKAMGEMNAASRGLNGAALEREKQRLDKIRGEIVSGTWWKKEKGRGNGAAEKEERLPSEGDKENRIDDDEPRGAVPATNGASKSGGVSTDKGDEMDVDEKAKGVEDPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUU3</accession>
    <name>A0A1B7XUU3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152049.1">
        <property type="nucleotide sequence ID" value="XM_018307632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUU3"/>
    <dbReference type="GeneID" id="28871739"/>
    <dbReference type="KEGG" id="chig:CH63R_12658"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12658"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="28642" checksum="29E442DB1B5B4980" modified="2016-11-02" version="1">MSSPPWDYIAKLVCIGDSGCGKSSLTIRLCEGRFSPHHDVTIGVEFGSRIVPVGPPNALPPAPHLPASSNAQKTNEDGIAAPNGLPEPPRLPEPAAVDGPQKHMKLSLWDTAGQETYKSVTRSYFRGASGALLVFDLSRKQTFQHVTDWLNDLRQIAEPDIVVILVGNKADLTQDENNKREVTKEEAEEWAKRNGVFEYVETSAKSGENVEKAFMRVAERIYNNIQAGKYDLNDRRSGVKGPGAGGSRQVKIGADANKGSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVP7</accession>
    <name>A0A1B7XVP7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_12963</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152354.1">
        <property type="nucleotide sequence ID" value="XM_018307937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28872044"/>
    <dbReference type="KEGG" id="chig:CH63R_12963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12963"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="14">
        <location>
            <begin position="1336"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1286"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1562"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="440"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="744"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1056"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1289"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1572"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1584"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1598"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1635"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1670"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1707"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1721"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR03836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1737" mass="197075" checksum="C62CF631F9061795" modified="2016-11-02" version="1">MGKLIRLELFNFKSYKGHHTLLFGDSYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSAHLKDLVYRGRVLKTSKIQDDGSAQPNGQSNGHGNGEGDELSQKASRGDPKTAWVMAVYEDDAGDEQKWKRSITNQGSSEYRINDRVVTAQQYNEALESENILIKARNFLVFQGDVEAIAAQSPQDLTRLIEQISGSLDYKAEYERLQTEAEQAAENQSFQLHRRRGINSEIKQYQEQKKEADNFQRKTEERDEAIVKNALWKLYHFQRGMDESTEQIHDHQQNLQEFQRNVESFKRKLEAAQKEQQAAAKEVHGVEKAINTKKREFDELEHKLIPIDAKIEEKTRNIEQCRARMEPVRKERDKQAEVIKEDEGRLKTTEKAQKHFETQLKERMKKLGKELNEDDRKEYNTLRSQVVQKCAGNQARLDNLIRQQKTDEVTVNTLKGKVDTLSAALEKYEGELETLGERKASTEGNIKALSQEIDTKKKQYHQIQSERVRTSQRRTELEEKLENVAKQLREADDGRRQNDREARMKEMVNNLKRLYPGVKGRVGDLCKPKQKKYDEAVSIALGRDYESVIVDTEKTGHECVQYLKDQRFPPMTFIPLDNIKVNAVNGAIKGISGARLTIDTIDFDAAYERAMAYACGSSVVCDNEQVAKLISYERRIPVKTVTLDGLVIHKTGMMTGGRGPEPKGGKRRFESTDLDSLKNLATKYKEEIEKLPKSGRRSTAEESLQIEIHGLEPRLANAKAELAHLNKNYDSKKRERDNEERQLDELVPKYEEKTAELEATKRTVKEFSDAIAKVEDEVFSGFCGRLGFSDIRAYETEHRDMQREADEERAKFEVQKSRFQSQLTLARDMHSNLEKRLRKLQEALKAAERDLQTYQQEKSDIEDATHEVSDELDALSETLEEYRGKLAEKNHKVSQAKAEVHKRSKEIDARQKEINALETVVQKNSAGKFALLRRCKLDQIQIPLLEGSLDNLPNEDNMLRQDADAMDVDEEVDEEEMMTAALENYGIEVDYEGLDEEMKNSNDASVEEKLQDKIASLTSELEKLNPNMRAIERLESVESRLKNTEKEFEDSRAALKAARDAFNNVKAQRYELFNKAFTHIQEQISHVYKDLTRSEAYPLGGQAYLDIEEDTDTPYLSGIKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNANVDKIKKYIREHAGPGMQFIVISLKTGLFQDSESLVGVYRDQEVNSSRALTLDLRKTLAPSPIGAIALGPISLRPGAAMVEPRWHAQPQQSPSTLTSSSPHVNSSYPTSYIKTLRIFNSFDEGDGAMAQPLDLAKTLVKSVMRAFYETRHILIIDALIIHSALRDDDLAYLMATNTKDLHKACGKLREDRFLAVYTRLEYREDPKNPEAKPRPVNRTYYYIDYRQTIDAIKWRVYTVDKQIQGTTVPASERKEYFCGRCKSEWTQMEVLDNVGPEGFVCHRCGAPLTHDLERNSTGHEQSTRLNNQFKFITELLPRIDEMVVPDNTFDVAISKALPVVRDASYQSVTTIPVSSLQPTSVKGLDNVGPKSMSVSISTSDGPSEAEKAAEKARKEKVAQQNALPSWMSNSTVTGESFSAQAGPTAATKTEETDDKDAVIKSADNPEHAELDDYFARLKAEQEAEAARAMEEEEDDDEDDEEEDAFEDVTPSIATPAPLIKTEPSPDSEERVVKKVKVEAPADGDDGESDEDMEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXX3</accession>
    <name>A0A1B7XXX3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153134.1">
        <property type="nucleotide sequence ID" value="XM_018306293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXX3"/>
    <dbReference type="GeneID" id="28870400"/>
    <dbReference type="KEGG" id="chig:CH63R_11319"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11319"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="38533" checksum="24C29D9B310D7940" modified="2016-11-02" version="1">MMNDRPPPPADPDPVVPRELKAKRAVPSPRKAPTVRSGKGSIFGKASIPSVYWAGDDDSTPVNNDEFTFYREGTPPPLPEGGSRESEKDALARARGYRQSVFDHDEEDSERGRRRRCCGMRAWVAWLLVALVVAVALGVGIGVGVGVGARVGTKANQAASDGSAASIGSSPTATPTILIVPTMSSSSMGSITATGTTAASTASAASASTATGAAAESTGAASPPSSLSSSLSSSSPSPPPPSSSPATTGMSMLDSVSPTSTTGSSTTTASPTATSGPNAICPEADNTVYHVVGSDKRFLRLCGLDYTGDDGAIDMSDALASTMGECMEQCARVAQCTGVSWGNVLINGAPELRCWLKRDLKKSRATVANWNFAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXY6</accession>
    <name>A0A1B7XXY6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153144.1">
        <property type="nucleotide sequence ID" value="XM_018306303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXY6"/>
    <dbReference type="GeneID" id="28870410"/>
    <dbReference type="KEGG" id="chig:CH63R_11329"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11329"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="65"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="43215" checksum="0D6F464387FD1FEC" modified="2016-11-02" version="1">MTGWTHNTPDDTPTDGPRIAAICTAFTAAAFVLVCLRLYVRTMLVKAVGWETFLLSPSHGNADEDILTDDWVIIVSWTKWGLGITRLEDMPDEDVLNFGKVRKHSATFSLIPLTSFLKAAIYGRSIRPSSYVVGIWGFKMSLLCSYLRFFPVGGYKTGTIIVAVACTMAHIAFIFVFLFLCTPVEKQYDPSVPAEVGHCVDAVAFYMTFSSLTIVFDVLIMFLPFPVILRSQIQNRKKVVLLALFVLGGFVTVIQAIRIQTIQNLVNYLDSAKTIQWSVIETCIGIIIACVPPLAPMVKYFADRSRCRSGGGRSRGSGPPTNSSRYVLQTWGTKRSGMQPLGMGVDREASVVGSLQTKAEDSTENILESSGAAKATAAPGAPVTWSDKDRRQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY26</accession>
    <name>A0A1B7XY26_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153168.1">
        <property type="nucleotide sequence ID" value="XM_018306327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY26"/>
    <dbReference type="GeneID" id="28870434"/>
    <dbReference type="KEGG" id="chig:CH63R_11353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11353"/>
    <dbReference type="OrthoDB" id="4836623at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="29252" checksum="2142EBD158FFB93C" modified="2016-11-02" version="1">MPKFPTPSRCRHNLHHAGLRLRPFFDVLDNSCFLKWAIEIHQKPFPPPGVPYLDDQQGWEDYLNFDVRTQEELEIEESTPSPEQEGRHDSPHNGIVVAAAAAAAAADDHLDSESGPLVICKPDRLSLLHGEPQASLSPTEAFLFPPFGSLTVCNPDSGEALPEEQEGVSETTQEYILSQAPASPASPLHQSFGLEDGCERAPSGDSSDVYQEEHIFFWSPETAQAVPLLPVHQPRLVTVPSPPAPPYRTLLSQNPRRRGVVFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0S3</accession>
    <name>A0A1B7Y0S3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_09734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154132.1">
        <property type="nucleotide sequence ID" value="XM_018304708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0S3"/>
    <dbReference type="GeneID" id="28868815"/>
    <dbReference type="KEGG" id="chig:CH63R_09734"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09734"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="73"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="525" mass="58647" checksum="3683D943E116F677" modified="2016-11-02" version="1">MADATSTAADDAKSRRSDVEHLEQDLQKPHVEADDVQQQHPEIYMQALARYPNDESIDQAEEKRLLRKLDMRILPLLGICYFFYYVDKTTLSYAAIFGLKEGLHLKGEEYSWLSSSFYFGWLVWAIPSNLIMQRCRPAWYLSFNIFMWGALLMAQAAAQNFGGLLALRVLSGAFEAIADPAFMLITSMYYTRSEQPSRIAAWYAWNGVGVAGGGLIGYGIGNIKGALASWRYEFLVVGAFCAFWAIILAVLLPNSPRTIWGFTHDEKLIMIARMRRNQTGIEQRRINWGQIKEAYLDYKTWLFTLLGFMSNVPNGGISNFSTLVIKGLGFGTLETALLGIPQGALVVIWIGLGALANRYLPANSRTIVCALFMLPTIGGALGFLLAPADAYIGRLICFYLTGSYQASFVLSLSLITSNTGGQSKKMIVSGMIWFGACIGNIASPFFYKANQAPSYHLGIGSLLVANCIELALFFVFRYAFIWENKKKERLRAEMRASGNYVADELNATAFTDMTDKENPNFEYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0V2</accession>
    <name>A0A1B7Y0V2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_09751</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154149.1">
        <property type="nucleotide sequence ID" value="XM_018304725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0V2"/>
    <dbReference type="GeneID" id="28868832"/>
    <dbReference type="KEGG" id="chig:CH63R_09751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09751"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="261"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR05631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="56220" checksum="E1928482F6738F53" modified="2016-11-02" version="1">MSHQFHVAGASHALLDPWSNGLGIMKDVLTRWSELDITQIGSLIAIAGTLPAAWRLLQHAWREASACVARFFLASVTIPGGDPVNRSVVKWVLANRPRHYRSFTGRTEVGRATSDRAAALKKTRHAVQYCPHWTSRWLWFAGGFLVVTRAVGDFGSALSDPSYDGIGGEDLTISCLGWSAEPVRSFIETCREYADRQTQYFVLIYSRDRYGMSWKPKARKPLRHLDTVHFDHAVKRELLADIRNYLDPTTQMRYQSRSMPYRRGYLFYGPPGTGKSSLSVAIAGEFGLDLYEVKVPSVATDADLEQMFQEIPPRCVVLLEDIDAVWVERSTTSSSSSSSNNHYHERNGNGRAHSPEGSNVPNCTLSGLLNVLDGVGSQEGRIVIMTTNRPEQLDGALVRPGRVDMKVLLGNISRRSAEDMFVRMFSPDLGCTAHLDMDEIRRLAARFSSQIPEDAFTPSQLQGFFQVHLESPYDAVESVGVWVERELARTQYKGFELVAANGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y109</accession>
    <name>A0A1B7Y109_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154212.1">
        <property type="nucleotide sequence ID" value="XM_018304788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y109"/>
    <dbReference type="GeneID" id="28868895"/>
    <dbReference type="KEGG" id="chig:CH63R_09814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09814"/>
    <dbReference type="OrthoDB" id="5287717at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="682" mass="74679" checksum="42CF82874BBAE260" modified="2016-11-02" version="1">MTGHDYSHVVGAPAEDIQLVSSKDPHSDVTTTDVTPDTPLSTPRSRHLARTLVLLLVPLGITGYYFWIWLYLLSRDLDEAVKYGSANESWVFWSWFIVGVFALDWAAHGLVGVEVAMLETSFWRAPHLIGLLDHSEGTWGGPGGWVKCLTKLFKERNMAAIGGWYTSLNTYRLWYLLAFLTLSLYVGMPLSGITMELSDGYVPLDEAPMVVGRNSTDFHARYFSSTSGSSIYKGSETAWQVGSPATLPGISIIYTPEHVNRKDHDVLAQIPNNLPTDPEVPEMFLVPQASVPISGTSWGMRAGFNCSVVEDVSEFTIIGHNTTGLCGGGPIKICPRANMVDKASNIWSYMEVGSRMPMVGPPQVYSPTYDNTAPDPFGSGNDSQPDVFEFALWQVRVNASYAEIENFNNTVGPTVKGLDSPFMKADNGSWVANATFFDQKTFTARSKAKNDVWQRLIIQGRQTIEVAAPIGVRCVVRSALGSASLDPATSTFSNFKVEYPTMFSDPQVKAPSPVGRLGTRVEKFMPESGVNDIFTSINTRATKSESNSISLTKFVSSSELRKSISMGYVKEALDLMYDGQYGFEGSWEHAGLTSSRKGKILTTGDLSPLSAVIPFAIWTLGSLILGIVYGFRRRVADSLSGFSVFRLGVRSADRLGDSGLLEAKEAEDVGKLWRLPGSLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y171</accession>
    <name>A0A1B7Y171_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154277.1">
        <property type="nucleotide sequence ID" value="XM_018304853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y171"/>
    <dbReference type="GeneID" id="28868960"/>
    <dbReference type="KEGG" id="chig:CH63R_09879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09879"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="23331" checksum="37588AA9E138204D" modified="2016-11-02" version="1">MVARSARRTCGGFQPGRDVTSLLPEKHMQRLAANPTRAYTRDDIGLPRPTPPLVYLLVLYGDMCSAEAIRLFCAHERSCFGLAPAKHAREMERSDSQPLAAWGSKNQLPTRRISGAEGNHLESDRPPSYHGNQLQTFSAPTDRVRRLCLREPAMADNDPSRWSHSAGEAQQHDDRTNAANQRSSGSRGVVEEATPGVNGNATDLSITVSSGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1T6</accession>
    <name>A0A1B7Y1T6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_10093</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154491.1">
        <property type="nucleotide sequence ID" value="XM_018305067.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28869174"/>
    <dbReference type="KEGG" id="chig:CH63R_10093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10093"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="416"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="699"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="914"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR05973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1328" mass="146110" checksum="F22A08F6E131D057" modified="2016-11-02" version="1">MRNLRNIRFSAWEQQQDVTVTACCWDPAKDELLCTTGPTEAKATVELVRLSDHHQEQQIKSHTVTSWDAPSPSPDLPADKVVSLHHFADTLTTCVILEGGDIVTVQEDDAGRDGDVQIEIVGSIDAGISSARWSPDEELLVVVTKEGNAVFMGRTFDPIADVAMTPDDLRLSKHVSVGWGKKETQFQGKGAKALRDPTIPEKVDEGLPSVNEDGAATVSWRGDGAYVAVNSVAGGARRVVRVYSREGVLDSVSEPVDHLEAGLSWRPSGNLIAGIQRLEDRTDVVFFERNGLRHGQFTLRSADGPLSVHKKIGLEWNSDSTVLAVVLSDRIQLWTTGNYHWYLKQEVPLTSAFSGLAWHPEKPLRFVAATSCRFSPFSMASDILTKCAAVVNVAEYIFAVSRGSMSPPNDHGAVAVVDGQTVKLTPLRTANVPPPMALFELDFAASIVDVVFDPSNSLMAVLHRKGLDVYEWQTKGDRSTKPKELVKIAFDPGAKTRVPLQAAFSGPAECQVLVSEEGLKLETYTVEASSLIASGVTQLRTNETFSSIFSHEVDSGVESCAQDRSGKLYRLVGKQVPELFGTQLSTQLPWCEVRSINGRSVGIGMTRNGHLYANSRQLAKNCTSFVLTPAHIIFTTNNHFLKFVHLVDPEEMEVPGDDPEIDERCRSIERGARLITAMPTNMNLVLQMPRGNLETIFPRAMVVAGIRQLVDEKNYGRAFAFCRTQRVDMNILYDHQPSQFLSNVGLFLDQLKDISYIDLFLSSLRDEDVTQTMYKDTKRITRSLETSAEAPAAAPADLSAKSKVNKICDAILKSLQSKKSTNLQNIITAHVCKVPPALDDGLTLVAELMQEDEKVAEKAVEHICFLVDVNRLYDNALGLYNLDLALLVAQQSQRDPREYLPFIQNLHNLPDLRRKFEIDNHLDRRAKALSHLKALDAFEELSTYTAKHALYQEALALYRYDQARHQALTGLYAAYLESKSKYRDAGLAYETLQNFNKATSCYRQAGVTCWRECLFAAQQQTPPPSEETITELASSLADALWEGKEYAAAATIHVDYLASLETAVKCLCKGYHFAEALRLIARERRADLLPTTFDGGLVEALSSSTEFLADCKSQLLAQVPRVAELRRKAAEDPLAFYEGERPGGGAGGDIPDDVSVAASSRISTSASLFTRYTGKDGSVGTVGTGVSRATSKNRKREEKKRARGRKGTVYEEEYLVNSVRRLVERVEGGAKDEVGRLVFALVRRGMTERARAVEALMAEVVEGCKAAVREVFAGGNEEHEGEAMVGPDGETYMASGGDAVFQEHLEARAKKLEPPALSAFQKLTLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1Z8</accession>
    <name>A0A1B7Y1Z8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNase3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_10161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154559.1">
        <property type="nucleotide sequence ID" value="XM_018305135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1Z8"/>
    <dbReference type="GeneID" id="28869242"/>
    <dbReference type="KEGG" id="chig:CH63R_10161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10161"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="6">
        <location>
            <begin position="148"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="44998" checksum="4716D5D5DE365044" modified="2016-11-02" version="1">MSKRSSSGVLPPSKRRHTADEALGLLLDHSDELISCLQAFSGSKSVSSDRNEDLQNLRRLSKKLLPSFKHLAGEGPTQADAAQENNVSKNEVSKSKMDAALPTPREGPTSTAPPIPSFTLVTPWTPADIPNSMPPLPEISNPVLKMAAFTHVGVVKHKSDLSYDRLEWLGDAYVELISSSLIFQTFGGMPTGKCSQIRELLIRNANLGEYSAHYKLFERAKLPAEFRPNGNLPVVAKPHEIKKVRGDLFEAYVAAVVLSDPVHGLPRAAEWLKALWAMTIKDQIRTSARNPGMGIVKELGETVTEENQIAPKVRLSQVIGAKGITIRYEDLPSANKKDKYNKKLALFSVGVFLDGWGEKNKLLGTGSDLNKKEAGQKAAQMALDNKKLMKVYTEKKKAFMAALGETEDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2N1</accession>
    <name>A0A1B7Y2N1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease YSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154789.1">
        <property type="nucleotide sequence ID" value="XM_018305365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2N1"/>
    <dbReference type="GeneID" id="28869472"/>
    <dbReference type="KEGG" id="chig:CH63R_10391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10391"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="84" mass="8962" checksum="FB2C8E2355909A57" modified="2016-11-02" version="1">MASKRKASAMAATVSEEPVDPADELMFLCLGGGNEVGRSCHIIQYKGKTVMLDAGQHPAYDGLAGLPFFDDFDLSTVDVLLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y331</accession>
    <name>A0A1B7Y331_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_10548</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154946.1">
        <property type="nucleotide sequence ID" value="XM_018305522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y331"/>
    <dbReference type="GeneID" id="28869629"/>
    <dbReference type="KEGG" id="chig:CH63R_10548"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10548"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601286" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="16">
        <location>
            <begin position="387"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR06428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="993" mass="109399" checksum="9BBD6162D6FCB84C" modified="2016-11-02" version="1">MLLSRVKALSLLALAWLDGVSARAIGRDLKLLNGRQQDIVTWDDKSLFINGERLMIFSAEFHAFRMPVTSLWLDILQKIKAAGYNSVSFYVNWGLIEAKPGEVRAEGIFALEPLFEAAEKAGIYLFARPGPYINAEVTGGGLPGWLQRVQGALRSGDEAYLKASDNYTAALGGIIAKAQITNGGPVILFQMENEYNAAVPPYPFPDYDYWRYVDNQFRSQGVVVPYVNNEAWQLGAITALTPAKVDIYGHDSYPLGFDCWNPTVWPPNGLPTDWLATNDRIAPTSPYTIVEFQGGGFQPWGGAGFESCAALLNHEFERVLFKNNYAVGTTIFNVYMTWGGTNWGNLGHSDGYTSYDYGAQITEERLVHREKYSETKLQSNFLHVSPAYLEADRYNSSLEWTNNAAITVTPATTNSTKFYIARHTQYDSLETVAYKLKVKTVSHGDLEVPQLSDSLYLTRRDSKIHVSDYAVGDKNLVYSTAEIFTWKKYADKTVLVVYGGADEHHELAVEGEQADVTDENVIEGSDVTIEQRDGYTVLGWAVSDERKVVRVHEDLYVYLLTRNEAYNFWVPPAVGDFATSDVIVKAGYLVRNVAVTTDSLSFSGDVNSTTTIEVIGGAPNPLKALNFNGKSLDFKQNEHGVVTATVAFAVPEIKLPCLGQAGWKYIDSLPEIKPDYSDDLWTDADLEKTFNTANPLKTPTSLYGGDYGYHTGSLLFRGRFTANGDESTLDITTQGGNAYGASVWLGDEFVGSWVGNAVSPARNSTFTLPKLTKDKEYVFTVVVDNMGLNGNWVVGEEQQKNPRGILNYALAGHEQADVKWKITGNLGGEDYADRDRGPLNEGGLFVERQGYHWPSPPSGSWADSSGPTAGIDRAGIAYYSTTFDLDLPAGFDIPLSLTFANTTASAYRAQVFVNGYQYGKFVHHVGPQTRFPVPEGVLNYRGSNHLGITLWAMEAGGAKIEGLKWEVGMVSASGFGEVEPAPQPKWAERKGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3P7</accession>
    <name>A0A1B7Y3P7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_10705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155103.1">
        <property type="nucleotide sequence ID" value="XM_018305679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3P7"/>
    <dbReference type="GeneID" id="28869786"/>
    <dbReference type="KEGG" id="chig:CH63R_10705"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10705"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="477" mass="55239" checksum="A9EDCD5A37D8B86B" modified="2016-11-02" version="1">MQKKKRRLLKVVGHHDVGTVEEHWELVEDPYLNKYARPEDTKLVISERPEDQKYPSPHETLCGNESVKQIVTKLSSMVRSRLRFRSDVRSDSIYELYTALPEPRMVHISANLRHRLLKLFGMPRKKESQSMLRYFALVGEVKDCGIALQRTEWNYALALATRYVGRTTETEVEYALLLWREMEKQAGVKGNNITFNILFDAASKAGNFQLGEMLWKEMKARKIRFNRYHRVSLIFFFGLQENADGVRAAYKEMVEAGEMVDTVALNCVIVSFLRCGEQEAALKVYNYMKGTGSKAAVNFPRKDYFKDQVVTKILFMFASVGRMVPELRPQLQELAGTAPDMRTYRILIKHFGVERGDLGRVAQFLDEMWQFEVPVDGSVFLAIFVAFEKHGGKAFSAWTPARLEKVLSALLRAIDYKTEGLYLDTWLMGWALRAFMKCANEVRAGEVYEEFQKRWDLPPDRARYMEGYVARILHRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3R1</accession>
    <name>A0A1B7Y3R1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ubiquitin elongating factor core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_10758</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155156.1">
        <property type="nucleotide sequence ID" value="XM_018305732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3R1"/>
    <dbReference type="GeneID" id="28869839"/>
    <dbReference type="KEGG" id="chig:CH63R_10758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10758"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="46960" checksum="7B9E9F1D0EF4B07B" modified="2016-11-02" version="1">MPSAVGSEMIALCIAFLRSSEYIKNPYLKSSLVTLLFSGTWPFMHFKKGVLGDQLYGSKFANDNLLHALMKFYIEAESTGAHTQFYDKFNIRYEIFQVIKCVWGNDIYKQQLTRESKVNRQFFVQFVNLLLNDATYVLDEALTKFPKIHTLQQELEFGNSLSAQEREKKQEELQALEGQAGSYMQLANETLAMMKLFTSALASAFTMPEIVQRLASMLNYNLETLAGPKMGQLKVNNPSKYHFQPRVLLSDFVDIYLNLGSSQAFIDAVASDGRSYKPEVLDKARFILSKRSMKDASELEQFDRLKSKFEESKKITDQAELDLGDIPAEFEDPIMGDLMKDPVILPSKHIVDRGTIVQHLLSDPKDPFTRQPMTVDDVIPHTELKDKIEKWKGERIAAAKARAQGDAMDTTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3X8</accession>
    <name>A0A1B7Y3X8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xaa-Pro aminopeptidase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155237.1">
        <property type="nucleotide sequence ID" value="XM_018305813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3X8"/>
    <dbReference type="GeneID" id="28869920"/>
    <dbReference type="KEGG" id="chig:CH63R_10839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10839"/>
    <dbReference type="OrthoDB" id="3632757at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601312" evidence="1">
        <location>
            <begin position="22"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="208"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="465" mass="51660" checksum="94696309265D904E" modified="2016-11-02" version="1">MHWLTTFVPAVTALLWEPVLGDPTPKYNPLPPPREQARIQNAWTEERKAGIPALLKKHGVEAWVISQREYAEETVFWSLKPASTFSARRRTTCLFLAEPLAALSSSTSSPPEGSFASTQQPGCVVGWTSDVWATLKSQLEAANPATVAVDAHPEIAFASGLHAGEYRAMAAGLGGEWTSRMVVKPEIAVEFIATQPRSRLPRYRKIMETAWAMIARGFSARAVVPGRTTTADLEWWFREEMLAHNFSTWFHPSVSVVDEALPWAAEMGTEVEAGAHEGAGGRVIQYGDMLHVDFGLTAMGLNTDTQHLGYVLRPGEKDVPQGLKDGLKKGNRLQDIVRRNIAVGRTGNEMLKASLGEMHAEGIQGRVYTHPIGDWGHSAGPLIGMTNMQDYVSASGELAAVRNMWFSVELLVEHYVPERNQTLWFALEEDVYWAGEEKGWQWVYGRQEEFRLIKTAETQGTMEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4S9</accession>
    <name>A0A1B7Y4S9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155559.1">
        <property type="nucleotide sequence ID" value="XM_018303536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4S9"/>
    <dbReference type="GeneID" id="28867643"/>
    <dbReference type="KEGG" id="chig:CH63R_08562"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08562"/>
    <dbReference type="OrthoDB" id="10428373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="206" mass="22764" checksum="7539C220F6B12247" modified="2016-11-02" version="1">MPPASSASSLSFDPLRQADNTHSLTKSSTPSHLFTLADTAGLPCIAMYHCDITWNTPDPSEDQHQSHHRPQDRQHQGRQSREQKSVVPNETRTQHRDHFGFVNLLASNPALRGSRSPFARDFLASHHHHHQQLQQEPTPFASNSSHGRRASGQLRSISPPRGLVSYQRTLLSPPPPPTASRARNAQPALLRILTSITSGLDPGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5B9</accession>
    <name>A0A1B7Y5B9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155767.1">
        <property type="nucleotide sequence ID" value="XM_018303744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5B9"/>
    <dbReference type="GeneID" id="28867851"/>
    <dbReference type="KEGG" id="chig:CH63R_08770"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08770"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="75" mass="8173" checksum="488AD2887538DF05" modified="2016-11-02" version="1">MPTEAATPAIWGKAAVAGEHHAKFLRAGRFAPIVAAASKPKYTRARVKNAMFSELELELQLDDHSGAERYADHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Q3</accession>
    <name>A0A1B7Y5Q3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155793.1">
        <property type="nucleotide sequence ID" value="XM_018303770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Q3"/>
    <dbReference type="GeneID" id="28867877"/>
    <dbReference type="KEGG" id="chig:CH63R_08796"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08796"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF15">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTIONAL COACTIVATOR MDPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="327" mass="35915" checksum="94F0E9CDF92CE15D" modified="2016-11-02" version="1">MAATDGILCSPQPDRVAHTPLSAQMYKKPSYLDAIRFTAETVVPTSLRMADATRRRMRYHQEDANPFRVTTDSSLSLASACERDHKLRRSAITFRRLTSVNRTSAVLEILSSVGLEELEQTVVDLTTMTLMADEMTRQVNSTSTAIAKSLRSRNPSLHCVVQMHEGTKQKSEPAYSSQRIETSSWLEIQSRAPGTTQNETNAAVYLLHVPDPFFYASSSAHAELRAHFDVLRTNETVTVILIADVVPQSGSRGGRGGSPDGPAEARALLNDVLLLQAGHDVVFDMKRLEALSEFAREGADRVTVVNQLSSASHSLVAFVLRSRSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Y8</accession>
    <name>A0A1B7Y6Y8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_09324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156321.1">
        <property type="nucleotide sequence ID" value="XM_018304298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Y8"/>
    <dbReference type="GeneID" id="28868405"/>
    <dbReference type="KEGG" id="chig:CH63R_09324"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09324"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="91"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="310" mass="33964" checksum="2E894A2A89FE894B" modified="2016-11-02" version="1">MTKLILSTGSNLELTNSLRSNFLAAQQDYSPAEDSSPIDDEPVNGNGVLNGHSNGFSHSDSGRPRIDVWTVRENDALYIPRIDWSYSGLQEESDNYDITVKLFFLPNAPAQDRARYVQDALSLVRKELGVTTIDLLIASFPGMSFEGDCEWEADKRNASQGNIDEEAATWTVLEDLYNRGEVKALGISEFGTEKLARFIKKVSVRPAVDQINIKDCCSVPPTLVKLAKAEGVELLVHTDCTDILPRGTLRDLLGHGLQGAGVLADPAEGKDGLEGDLTPEWVVKYTAFVKDRGVIENKGYFAGAELVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7E3</accession>
    <name>A0A1B7Y7E3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156467.1">
        <property type="nucleotide sequence ID" value="XM_018304444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7E3"/>
    <dbReference type="GeneID" id="28868551"/>
    <dbReference type="KEGG" id="chig:CH63R_09470"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09470"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="33922" checksum="936CC8BC8F554181" modified="2016-11-02" version="1">MASCQVQGEPELYGLGIRVAFYIQWFGAIVVEYLEVADLPDMRLVGLLFSAAAFVGLVIQLSMAALQPADIYIVLLLAMGIYLPLVPLYAWKAVTGFNPYWDPFRWSNEPSRAFRGLDFTLLLATTSLAIWYWCSFVPENPCSSGQYGFLFSRVSLGNKGFIASNAIMYFVILLVCLLVLLLMVGWRVPFWRERRKKRRVKKSHVIVVKELRTLSNIAVAATLTAAVELTVSWNDITSANYVSDVAQVLPLLVSAGFLVRVLFLHFAGVDGESESSEEDSDEGSRSYTTESPGGLPPAPPPAHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7L0</accession>
    <name>A0A1B7Y7L0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carotenoid cleavage dioxygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156463.1">
        <property type="nucleotide sequence ID" value="XM_018304440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7L0"/>
    <dbReference type="GeneID" id="28868547"/>
    <dbReference type="KEGG" id="chig:CH63R_09466"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09466"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="642" mass="70029" checksum="3BB3D50899ADF053" modified="2016-11-02" version="1">MSTTTITTSATPIAMTSEAKIPARTVRRTAQDEAADLQMFKENRLRAPYDEWPNEAGFDGLTEERGPIELTVQGHIPAWAAGALYRTGPGSCKVEDTPKGTYYVSHWFDGFAHTHKFDIVAPSKASSFAHGRTRVLYSSRRQCDELVASVKATGHQNRYTFGQKADPCIGIFGKFMGVFSKGDGPNICVAVSANVPGFDSRESDDDKEKSGQEEDKRSGGEKSDGTPDQSPSGSGHRNRVRSLWLSTDSSPLQEIDPDTLEPVGIATQDRLHPDLSGPMSCAHAQRDPETGDMYNFNLALSMTSTYRVFRTSAATGKTDILAAISGGDAKPAYIHSFFLTKSFVVLCIPSSHLAYRGMAVPWQRNILDAIAPFDAANRCRWYFVDRLHGKGVVASFETPAGFFFHTTNAFEEPSADGPGLVDVFCEISGYQNLNILHNLYYDVLLNRNDATTKFWTENERLNNGYASLQRFKFRLPDPSRDDDAGTSTAAEAAPTEPELLVSIPAPHAGELPTINPDYLTRRHRYVYSLSDRGLSTLLDTIVKTDVDTREALMWECPRAHTPGEPIFVPRPPTAATAADGRATAVAEDDGVILSVVLDGTTQRSYLLCLDAASMTELGRAECDFAVGMGFHGIHAPSGPGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y846</accession>
    <name>A0A1B7Y846_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Class V chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156695.1">
        <property type="nucleotide sequence ID" value="XM_018304672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y846"/>
    <dbReference type="GeneID" id="28868779"/>
    <dbReference type="KEGG" id="chig:CH63R_09698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09698"/>
    <dbReference type="OrthoDB" id="4806132at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601415" evidence="1">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="217" mass="23935" checksum="1D0C712A23385FC2" modified="2016-11-02" version="1">MLLSTLLLPLLLQAVAAAPTQDATTALDASSSDSDHVRTEQFTTSDGETYEILINGALVDDTAPGTTPAMHERQTTVMEPLWFPDGRAKDECGSSSFIKDTGPNAPTTGRCRVLMEWAKANNGFFKTYNHHHANGRATWLLKTHPSGKNACAFWIKHDATIGYIGNTDVADLIRDSLKRFEMNFSGAWRVRARGETTCNGYAPGRHKASFTWWVDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8A4</accession>
    <name>A0A1B7Y8A4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156770.1">
        <property type="nucleotide sequence ID" value="XM_018301992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8A4"/>
    <dbReference type="GeneID" id="28866099"/>
    <dbReference type="KEGG" id="chig:CH63R_07017"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07017"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="89" mass="9918" checksum="324CCE8864CC08F2" modified="2016-11-02" version="1">MCERRPLRQFETPEMLDSVEQASEGAVAQEDHGKEAFVVLLGFNGKNKSADRPFSGMKGTVELPFWHAPRSQESGPVQHSPSQLQQSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y941</accession>
    <name>A0A1B7Y941_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157121.1">
        <property type="nucleotide sequence ID" value="XM_018302343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y941"/>
    <dbReference type="GeneID" id="28866450"/>
    <dbReference type="KEGG" id="chig:CH63R_07368"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07368"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="29452" checksum="203D6A792745A4CC" modified="2016-11-02" version="1">MNTRSSPKRQKFAVIFVLGAPGSGKGTICTFLARNHNLLHFSVGDNLRAWMEANRETSLAARIQEKLDHQGFLTSAELNPLLGLAIENAMRQDNLKGILIDGFPRCEEQLNSWAKWPFQEKLPLEGDPKPDVVLLLNVTRENAEARYLARGRDRNDSAEKFTRRFAEYLEEGLPVERYYRQAGLLVDVDNNGTVEENIAGLQKTLRGSALWSSAVGDQDMKPSSLYEHSGAVYLEGAESDQVTVSRDGYGSRFSNVAKPHGPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9F7</accession>
    <name>A0A1B7Y9F7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157132.1">
        <property type="nucleotide sequence ID" value="XM_018302354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9F7"/>
    <dbReference type="GeneID" id="28866461"/>
    <dbReference type="KEGG" id="chig:CH63R_07379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07379"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="112" mass="12148" checksum="324CC4C67D49879D" modified="2016-11-02" version="1">MYQEKELLYGLFQLSQRDRESIPRSITPVITASLSSYDSFGTALDTFSGLSPTSAAGAHLAQVPGGDADDDTHDLRAEPLAAEAAHYAKKDDGAPPRRSVIPRTRHETNGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB20</accession>
    <name>A0A1B7YB20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_08056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157808.1">
        <property type="nucleotide sequence ID" value="XM_018303030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB20"/>
    <dbReference type="GeneID" id="28867137"/>
    <dbReference type="KEGG" id="chig:CH63R_08056"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08056"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="221" mass="24100" checksum="767B2738B0FBF630" modified="2016-11-02" version="1">MHAPRESRDGGHPSSAASARGNFVAHVESNSNGEANKELNEHLEVNTDVISTAPVSGTDGELAAEEQFESTSNNTANKNEIVGTSYKGPYSNVDDADVSAVDTYRPDPYDFGRHRRDNVSKKQMAIEHPKGNKRKLKKFYNRQNVLIDQFLGAEDEERQQVAEDARMGPKIKFAVNASFTANFCLFVIQLYAAVSTGSLSLFATAADAFVSRPVLSDAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB68</accession>
    <name>A0A1B7YB68_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157829.1">
        <property type="nucleotide sequence ID" value="XM_018303051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB68"/>
    <dbReference type="GeneID" id="28867158"/>
    <dbReference type="KEGG" id="chig:CH63R_08077"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08077"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="280"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="510"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="672" mass="71213" checksum="D944E729B9A8F528" modified="2016-11-02" version="1">MAAPRPYNNSNNPGYMPNGASSIPPGAAPLLPNQGRVIQTGPIRVLCIADVRGNLTSLNDLARQARADHIIHTGDFGFYDDTSLERIAEKTLKHVAQYSPLISEPVKKAIQQGGPGPVKSRFPANELPLSELPLLLSGEIKLDVPVYTVWGACEDVRVLEKFRSGEYKVQNLHIIDEARSMLLELGGVKLRLLGLGGAVVMHKLFDNGEGRTTIAGGQGTMWTTLLQMGELVDTAHRVYDPTETRVFITHASPAREGILNQLSVTLKADFSISAGLHFRYGSSYNEFSVNPTLDHYRGKLAASKASFNDVWETVKNEVEPAISQNEAQQNLLKNALQIVEKMPTTAAGGNPFGGPVAGQAQLGQVDESAFKNMWNFNLADAAFGWLVLEIQDGRIGTEMRAQGFNFSHRGAKAAAPVPSGPSGAGNLPAPAPPSTQTTAPPPTSRQPSSQAPPKPAVATPLPPTKPATPQPAATPAPPAVPAKDERPAPANGSAHGPDPVSSPAPKTPAQDIIGLFIMNVSSDEQTRELFDGEHRNNILKIEKWGNSNKVVQFKTVEDRDAALNSLPEDLKTRAQEDRSRPLVKVFQHRESKFQPRGGAGNWGSSRGGGNSANTGSGYRSAGGASDSESTRRGGRGGGRGGRGGERGRGRGRGGLKGEGGASPAPGPATPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBA0</accession>
    <name>A0A1B7YBA0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_08107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157859.1">
        <property type="nucleotide sequence ID" value="XM_018303081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBA0"/>
    <dbReference type="GeneID" id="28867188"/>
    <dbReference type="KEGG" id="chig:CH63R_08107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08107"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601497" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="184"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="511"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR09342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="869" mass="93785" checksum="59146CF37848EF84" modified="2016-11-02" version="1">MGIIGLTLIQVFFCESALALFQQQHVRLHATHQDPATVGQLNIRSLLLDTRDLTCLTETANFTVTVRVTRGAQQTSAPIFDSTEAVSAITTSDPTGTVVILPSLTNKVPQTSGFIPSSLETSGKATSCPLLSNTIPVPTTLIDSTSPVTTVEPIPSAPMPSGDIFAEPIATVAPPGSIPVRNDHPVPRKGITSSSPLQTNKFYSNFFLGDQTAPTYTYPYGIAWGAGRGAAASFGMTISHIEANQRVFGPTKSSGAAAYFINPVGIQSMVISALELGPDTAVGVDSVTAFSATIHLKPNAQAVPAISFPLVQGMPFITARYAGATPVIRTGVFFKTVTRVTQDPKPGVAKFTFQLEDGKIWRLYAYATTGPQLNLQVVNNGLAQSTQPFYGVIQIAKDPGNGEALLDHAAGVYPTTVDLAGSVSGTTGSYTFKFAKSGHPEGNLVMYALPHHVASFDSTTRNAVQPVQILTPTKGTATAVLADQWTMVEAEMPVNMDFSPWSPERGSLTTLSDNARVVIRGIAAQEVSQDMMAQSDLDSMYFSGKALAKFALLIVVINDILQDPALAQSGLNRLKAAFARFAANQQRFPLVYESAWGGVVSSATYVTGNDGADFGNTQYNDHHFHYGYHILAAAAIAHLDPGWLNENKDYVNALVRDVANPSTKDAYFPTWRAFDWYHGHSWAHGLYASYDGKDQESSSEDMMHAYALKMWGDASGDVMLSMRSNLQLSIIARALQHYYLYKSDNAVQPPQFIGNKVAGILFENKIDHTTYFGANIEFIQGIHMIPLLAPSPLVRTPDFVREEWDVYFSGGRVDGIAGGWRGIIYGNLATIDGRTAWDFFNSSNFDPGWIDGGASLTWYLTYAALMGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBB6</accession>
    <name>A0A1B7YBB6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157879.1">
        <property type="nucleotide sequence ID" value="XM_018303101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBB6"/>
    <dbReference type="GeneID" id="28867208"/>
    <dbReference type="KEGG" id="chig:CH63R_08127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08127"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="100" mass="11136" checksum="EBA9DF0ECFDFCB0E" modified="2016-11-02" version="1">MNSLIPTDGWIGRQQARPGWRRNWGADAPYNYATKLGDDTVRLEWRRHGFQGGPSGRVDPETTGAGNQNMGTFRRGSEFTLVACEFQTEFSDGVAKSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YC10</accession>
    <name>A0A1B7YC10_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158012.1">
        <property type="nucleotide sequence ID" value="XM_018303234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YC10"/>
    <dbReference type="GeneID" id="28867341"/>
    <dbReference type="KEGG" id="chig:CH63R_08260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08260"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="666" mass="72683" checksum="CEB4C6D5FFD16BA5" modified="2016-11-02" version="1">MNPPPCLRYIDDLIAENQRLKNDSNAAAQARSEALLPDIHIGAPPAKDTADNAAAAVTTTATATATATATAAIPPPSLDDRPWFFEMNIPHTPILIGEASDAAFATRFRQAISSAEHSHIPRVNYATDERLLALSDTDCPWPGPARARFLVGVALRYVSRCYHIVRKGPVLDALEQTLLNPAESDSLLKSKLWALFAIGAMYSTRSASSERHFPGMGYFARATRVLRIVSERPRIDVVELRLLLSFYSLALNRRHTAYTFAGSATRLAVVMGLHLNVPESQLRDAAAREHRVRVWWTAYIFDRMWAAKLGHPVAVQDIDIEVDLPSNPAVDESVADDFADASYFVASVKLARLLGRVVPSIYRRRAQQTSLSHRVQEALKELRAWSGELPPQLHIDFKPTSERTPKPISLHLNFNQCAVSTTRPILLHVLRTHVASWGTPAAPEPRIPATAMTLAETCIRCARHSCRLLTECWIDGSFATFDYFYTQYLFSAATILAASSLLSGGKEAANDREQFEEAAQFLSQLKDSGNFAAEEFCQHIDAMKATMAAARARRGGYADVPAGNTAAGAPYSSATTSSSSSSAGVVFSDAAGSTFVGDAVTLGQPFEAQNTTAGMALNEPSLQELLAQPLLDLQFIDASIYNDGAQGLYWPDFSPESWTPDTWTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YC87</accession>
    <name>A0A1B7YC87_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR/MLP1/MLP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08349</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158101.1">
        <property type="nucleotide sequence ID" value="XM_018303323.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867430"/>
    <dbReference type="KEGG" id="chig:CH63R_08349"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08349"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="484"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1067"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="931"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1584"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1712"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1851"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="223"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="421"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="570"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1303"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1466"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1592"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1735"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1892"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1902"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1914"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1939"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1974"/>
            <end position="2034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2042"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="2062"/>
            <end position="2085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2122" mass="235619" checksum="FE11B1FACB49AEA4" modified="2016-11-02" version="1">MAAAVDVGYVASHLGLSEATVSTATTDPTPDLVASLLEAVIAKAREHDELYAQKLQVDIELESAHHSAESRCQTFKATADKALKDVEEVRQKLREEETKRQTVENELQSLKSRGSDHDSEITTLRDRIESLQSSNRANMALLESRNARDSELSEELAKQHQKNVQLQKEITSLQQSVQTAQAAVSSAKYREESLQQQLDLARRNSEWFETELKTKSEEALKYRREKGARIAELQRQNEDAKSSIESLKRSEQQLRDRLDAAQAKAEEALTKVQQQQEAFARSEESYKHEIESKQRVVDMTNQLADSHKARVQTLEAEKEALKEKHGNEIRRIQQELERERESCRALEERVTQLEGEVDELHARMEQAPARGSTPTPQTPRMNGSFLGRPASPFATPASARSKSAITATQAIDELYKVKGQLAGEKRRNQQLAEELDNMISLLEAKTPEIEELQNEADTLRAEITRMSELSQTSFEERDVAKKSARKAESALANAQAESKILRTQLRDLSTQIQMLVFNMHAREKGVDQLTREESIRLEQLSRGEITEGALSDMSDTHQFITQKFVVFKDIQELQAKNQELLRVTRELAEQMESEEAVAAKSQAVEDHQAVERLQQELANMIDETKSLRTTMESFKAERDMFRRLLQQKATAGELASILGSDDGQRPPLATIENEAGDGVSTQTALRALQVEFDTYRNDEESVRRSLREQIDKLSSEKNSLQGEVAKISSQLTLASERYEMLHSNFVAVQSENKELQKRNQSLSEDSIKHEIRTQQVAEELIDAKGLLESARNEAANLKAEKKLWKDIQDRLNQDNESLMQEKTRLNNLLASQQSMQNERDISESEYRRKAQSKIDALEQELGSTKRKLSDEMEEGKKLQLRKEFDARESQKRIDELSSSLSQIREEHVAVKTSRDHLQARVDELTIELRNAEERAGRLAPRPTPRPGTMAPPAQTDQENEDEVRELINEVSDLKRELDIAKSQLENAKEQTEQYKQLSEQNEEALSEFTASQEQYREEMEAALTGKDAKIKELEQRVEDLSSELANSNKELSHLRDSQAEVARKYEDEKTILDEEIKRLKEETERHAEAAKFHQQDLRAQSEITAKAQQDYEHELVKHAEAAKLVQQLRTEYNELKSQSATLRAEAESAKVALSQSESSWEERRQRLEQEMLEIKTRRDDVNAQNKLLHEQLESITKQFSALKEGRNSAAEDANGSTEGGGGGDNAADGLRELNNYLRREKEILEVQYDLKVQESKRLQQQLEYSQSQLDEARLKLDQERRSQAESGQASIAHKDLMDKLHELNLYRESSATLRNELAQARAQISEKNAKIEELEGKVQPLEARIEELQTQKGFLEDEIKQVQEDRDRWQKRTEGILTKYGRVDPAEMEQLKQTITNLEAERDALKQSEAPLRAEIEETKQLLETERANWQNTRQRMTDQFKERSRKLTGEKNDAITARNEAVTEKDAVVAEKDQLLQQVNAANAELEAARQNLQVSTQQRTEFEQQIQSFQQQVQKLQQDAQAAPSSGQGAQLAPDASASVSTQIVAQLEQQLTEIRSQLDAVSAQKATAEQELDNLRTQLQTATSERDQAIQAAQQAAQSQPQPASEAGEINEGATATANGTTASGLSDEERKALEEKIAAAEAKAAEYERKANELEENITQTIKERSDKMRNALNEKLRQSREKLDEEYKTKLEQEKIIWKAEHQSTATAAATAAPGQAVDEQQPAVPATPIKQQDSDAVSTTPMAGTPAGSADLSQLPDAEIRKFLSTNPTVRSIMSSNLRKKLEEQTAKVKNETESVLKAEYEQRIASAREEGQMLAQKKSALQINMKDSQLRGANAKIEVVSTAAVKTPQRPVGEVWEEAKAAKAAPPAPQPSPVKPAGTAQQPAAPRPTLPAPPASAAQAGATPTGKSSLGGTSHLARSNTAQAVPNASVNQAQPPASAPSGIPPPGSTIPQKRQIPAPGENKPAVANAGAGANPFAQGAQAQQAPQQQQQNPFASSTQGAPAGQQGQQNQQGQAQQQPATHGQPAQRSNIPLPGRGGGVGRGRGGFAAGNRVSSGGGGERGGMAGRGGRGGRGGHGAGALNPGVSDFQPGNKRPRGDSEAGGGAGAKRARGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD95</accession>
    <name>A0A1B7YD95_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sin3 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158514.1">
        <property type="nucleotide sequence ID" value="XM_018300664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD95"/>
    <dbReference type="GeneID" id="28864771"/>
    <dbReference type="KEGG" id="chig:CH63R_05689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05689"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="894" mass="99349" checksum="06B17FDDEABAF1AD" modified="2016-11-02" version="1">MEMAFRFPFPVNDARMHREEELTLARVASQRGSNRPSPLDTPLPLEAQKEVSAESSTVSSLPTTKRRWVFADPVAFRYLESDPSVTVLERRGVLQGYELYLVEQWACSRKSPTLVIVTYTGDPKHSVVVGVLAVPADESVWSNRLRFYFKAIHQYHARPKETPLGDVMVTNLSSFPSALTVIPVPEGDIRTHRQAFIVNENLKRLGCSGRSGMNLSDPTPATQAKFYQLYRTSEKVPFAQSVVELVKLCQVSLFMFGKLDMEYIDGLLCDKTEESIGNWWTEIGAESYNVEPTDGILGPTTVAALLGLLMGARNRLHYYGAPVSKDVFDIESTKRGIGYFQKAYKLERTRRLDRQTILKLHAVTAKAAAGEGWGVQKAVKSTVAEIGGKRGELVIGMVGGKDKAGIADIETVDIDKFIALAYGERAKWLWYGKPRRTVPELQEKPTDVAQPLFGKDEVASPPGKRTQSLPLEEELQRQKEDSPGVYSTPAPASTVSVVDNPAEKDALRKTVFKSVAGRVSDAKSGLGRIKDVVGTGLRGHASRPSRDDFGENGYNGASGISALAQSSAALSSPVMVGRAFTWKNKPEEYLTAFKKEADIVQELRGPSQELEKVPVATKPIREVSDPGSAHAEGDHPTPPNGPVKDEPGRVQTSVAGSVVDEADLHGPFEAERTSNTAVSFLQRRHSIAVSRLSYKHPLNEARWPRRLSFGDAEEAVLRWEEITELYDDKHFSTADALQQQVSLAEFARSLYDSIATIKREVNPWVESKVKAVDSLDEHYGREQEDLQNLYYQLSEAYHRVKQSSTELIAEERAHITEAIKEVEVLVARLEYEINGLVSKVDDVEDGVRLFERQVEDVEKRAEELKATLETESWAHWFVRTLTGIGTGPNITRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDF4</accession>
    <name>A0A1B7YDF4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158375.1">
        <property type="nucleotide sequence ID" value="XM_018300525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDF4"/>
    <dbReference type="GeneID" id="28864632"/>
    <dbReference type="KEGG" id="chig:CH63R_05550"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05550"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="192" mass="21163" checksum="5EE7BBFDE362401B" modified="2016-11-02" version="1">MSVNPSSNSAAAAAAGPTIPEGAQKATIAAGCFWGVEHLYRKHFQGKGLIDARVGYIGGDLANPTYRAVCGGDTGHAEALQVVFQPADVSYRQLLEFFYRMHDPTTASRQGPDTGPQYRSAIFFHDAEQEKVAREVTRLANEQWYGGKIVTDVIPAGQWWDAEQYHQLYLNKNPSGYECPSHFLRTFPPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDI3</accession>
    <name>A0A1B7YDI3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158481.1">
        <property type="nucleotide sequence ID" value="XM_018300631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDI3"/>
    <dbReference type="GeneID" id="28864738"/>
    <dbReference type="KEGG" id="chig:CH63R_05656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05656"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="313" mass="35172" checksum="6A63832A93813DFB" modified="2016-11-02" version="1">MPQHRPIEAGQDVLAALAQTSKSLMDDENGPFWHRVLLHTFIESEGNAERSTIIKSPLEQHPELLQCLAWGLNVHTMIRPHSHQSLSRLLEYLTRDGQLLTVTYDVTVSNIVGVVQTLACGAIDFLDLSQRLLSPSRKDQATSERAFLQALLAHVCDINVMFYNTNVCHDLVDAGARLDIRAANGNTVLRSLVHGHINFSVLYHPRLAAWVSVEEIRRHQAGKAMVNSLNKDGLSPCHLALGDEISFSGNEDFVDLLARNGADITFPIPRGRHWDYLLRKLADWEAETETTEPWTHERIGRRVQVVRQALECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF09</accession>
    <name>A0A1B7YF09_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159027.1">
        <property type="nucleotide sequence ID" value="XM_018301177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF09"/>
    <dbReference type="GeneID" id="28865284"/>
    <dbReference type="KEGG" id="chig:CH63R_06202"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06202"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="275" mass="28278" checksum="985797C9C69F57CC" modified="2016-11-02" version="1">MAPHTYKYLNKLAQKRVLVIGGSSGLGYAAAEASIEHGAAVILASSSPAKLASAAARLRDSHPASQVPSSPIPAPAIATFAIDLADLDNLTANLTTLLDAATDGGASKLDHIIYTADAASPLPPLSETAPRHITSALSLRAHAPLLLASVLEAAPGKYIFSSPDASVTFTNGSSSHRPMPGWAVADAAAAATEGLVRGLACALAPLRVNLVSSGPVTTELLRSLPEETAELFRAKCLTGRLGRPEDVAEAYLYLMKDGFISGSTIFTEGGRILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFZ2</accession>
    <name>A0A1B7YFZ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zn 2cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_06689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159514.1">
        <property type="nucleotide sequence ID" value="XM_018301664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFZ2"/>
    <dbReference type="GeneID" id="28865771"/>
    <dbReference type="KEGG" id="chig:CH63R_06689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06689"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="714" mass="77593" checksum="D81472306617F78B" modified="2016-11-02" version="1">MDTSSTARRKSTASSVAASGTETRPRRVRPSRARGLRTSTGCLTCRRRRIKCDEGKPKCAQCCKSDRGCEYAQPAAPEEALETRHRSQSVVSTAADQDLPDDYLPGLPNAAEGTTDSGVVVTPPVPKDAPASTATAAVAAAATAHPVDFATPFVPSFDPADPCGTTLGVEETLQPSVSDADLGFSPLALSQTSLLNISPFEWYDLLAQDAINNIQRLNSLSGGETRWAFDESTLSRRQSPIPESPRDGNEGPPGFGQEDAPVTQPWNTTSNIELSESDLAYFRYYVDVVGPILDLFDPERHFSNVVPHLAVRNIGLLKSILAVAARHMSLGSTASIDDGPAPSNPPSPDTSYPGGGQAETEPARMATQFYYETLQYLSHTLLYPSYANSHEILATAIMISTYEMFDADGPSTNGDWERHLRGAFWIQRSQNNNGESADGLRRAVWWAWLRQDIWAAFRSGRRTLTIFQPQRRIRDLGSDELVTRILFIAAKCVEYASRDADAAPVRDLQHRLNHGNRLLRSLEEWRQALPASFAPISAAPTPVPETASAAGIPFASSPTSSAGHSRRDSVCASSVKSASKQIFHPVWIHPPSHAGAMQMYHFARAIVLLAQPTTGGLNAYRQRQRSLTESLHTVCGIADSCRDTDPAMAFVNVQAVFAVSENGDADDPITVGQCAQDKQKQSEILPILDRALAISKFPVKGLTQALRRLWDEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI00</accession>
    <name>A0A1B7YI00_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TfdA family Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160109.1">
        <property type="nucleotide sequence ID" value="XM_018298863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI00"/>
    <dbReference type="GeneID" id="28862970"/>
    <dbReference type="KEGG" id="chig:CH63R_03888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03888"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="242"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="55940" checksum="83257ED72B64AD4B" modified="2016-11-02" version="1">MALATVFRPALRSTGMLKSAARPSLSSRLPGRRPLIAPFAPVHTTSPKPQEAAALREDPDVVVRQAAVPRSTAPSVDDLNRSLDLLSSSSNDLTRRVEESLDALRHPLRYESPKDTPHLLHVTDATTNRPRAVLDAAWLRDRCPCPLCVSPSSGNKAFATTEIPSDVAFDHVQQSADGALQVRWANDIPRAAAAEHVSVFPAAGADSIRAMTLEKPVLFARHTWAADHTPKLAWTSANLAPELLRVDYADFLAGGPSFRDAALSLSRIGLLFLTNVPKSETAVADIALRFGAVKETFYGRTWDVISKPDAENVAYTSAYLGLHSDMLYLESPPRIQLLHCLENSCSGGESIFSDAFHASSYLLRHAPDHYRQLCDTKVPYHYNRNGFFYRQARPVISHSEHHHLREVWWSPPFQAPFPLNDTPEQAAAWSGWLAAARAFQDVLEAPDNVFQYKLRPGECVIFDNRRVLHGRRAFDTGSGRRWLKGTYVADEDFKSILRGISRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKD6</accession>
    <name>A0A1B7YKD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160901.1">
        <property type="nucleotide sequence ID" value="XM_018299655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKD6"/>
    <dbReference type="GeneID" id="28863762"/>
    <dbReference type="KEGG" id="chig:CH63R_04680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04680"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="428" mass="48032" checksum="DDB05718C69CF90F" modified="2016-11-02" version="1">MDRHSSVSGETPSSTHTPPVNRPLGRSRLSATPLTDTPPTSASGGRAGTPASDRILSGRVKKTSRKIATRKDDVLSEKEKEEERRQLEEMDEERKLFPGSDTWAEDELRLFKILYMRQYCPLLPSHWGMDFRGIPIPDILFASSDAHPPLINSQSGTDFKATRALARLIDVTANVRGLCQTRQRHRARVFIERELQEYTKWAEQDGEYGDVEYLPNLIIDMVDTTMTPQAIEEHMQLRLKAAAATHRAHWRNDMPESFGSGDHGTDKHQSKDDDDEDAEPEDNRVVLVPDKYPTPSPPKPHPAPPSTPAHKGINYDGFEDRSSASAELDNPAKSMTYQQDGQYTRRPPVLYGLFIVNTSVMVLTIDSAKEGDEAYVSYQVEVGFSKRYQAVWNAITIAIVVCLARDAMIDMKEDFSHSMMDGDSDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKH2</accession>
    <name>A0A1B7YKH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161084.1">
        <property type="nucleotide sequence ID" value="XM_018299838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKH2"/>
    <dbReference type="GeneID" id="28863945"/>
    <dbReference type="KEGG" id="chig:CH63R_04863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04863"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="58693" checksum="A97C63B7B3AEB70C" modified="2016-11-02" version="1">MEGIPAETSRPAGVTADGIDNQQSEGQHAAEHMQGWALASLTLAFMSVCFVLALDNTILATAIPQISSDFQSLNDIGWYGSSYLIAQMALLPTCGRLYAFYNIKWVYCLSLAVFELGSIVSAVAPNSMTLIVGRAVSGLGAAGLVSGTTTILSYCVALKKQAILSPFVLGMYSIGSTVGPLVGGSITDNKALTWRFVFWINLPFGAVGLLLVWFALRKPPPAVQGGLPWLQKIRQVDIPGAILLLGATSCLNLALQWGGIVYPWSNANVFGCLIGFGLLLATFLYLQVRGKESSTVPLHIFRSRTVSASCGFMMLVQVAIVLQSYYWPIYFQSVRNTNARDSGINLLPSIVSNSLGTFCAGWISSKTGHYVPLMWIGAPVLATGGGLYQLIRANSPMGEWIGFQILSGLGYGMCSQMPILAVQVVLSKSDVPTGLVMIMFFQMLGGALAPSVGQNLFTDGLLRNLSRVQGVDGAAVVAAGGVGFRDMVPPERLDAVINAFNSALRNVFWVALAAPVLAWIVSWAMEWRKLPDSKTATIQAPPTTEASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKJ3</accession>
    <name>A0A1B7YKJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161087.1">
        <property type="nucleotide sequence ID" value="XM_018299841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKJ3"/>
    <dbReference type="GeneID" id="28863948"/>
    <dbReference type="KEGG" id="chig:CH63R_04866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04866"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="129" mass="14432" checksum="63BC248A8445D0B1" modified="2016-11-02" version="1">MMPEGLIWALEWLTQSTRFGSHSVSAPTRWSGPAVPSTWRSHAARARPLGWTVNKRQSQSTRADRGRQALFRLMWLWFSSSGFRLDLTPAPPSPLFQTTVRERLVRDGNQSHLRVGVLAAIDGISPGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKK8</accession>
    <name>A0A1B7YKK8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_04903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161124.1">
        <property type="nucleotide sequence ID" value="XM_018299878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKK8"/>
    <dbReference type="GeneID" id="28863985"/>
    <dbReference type="KEGG" id="chig:CH63R_04903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04903"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="120"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="340" mass="37142" checksum="E7F950BF13103879" modified="2016-11-02" version="1">MAPEKRNKFLEADDSEDDLDRGYDSEAEELRKGGRSAKRRKVDSEDEDDFSDEEAHDVSKTDDGASGDEDGDGDADDGAEASTSSKKKSKTTTGLDLPDISKPLTKKNLVATEEAVKKSGVVYISRIPPFMKPQKLRSLLEPYGRINRIFLAPEDPAAHARRVKNGGNKKKSYTEGWVEFLRKRDAKAACELLNARTIGGKKGSYYHDDIWTLKYLKGFKWHHLTEQIAAENAERTSRMRAEISKAGKENKEFVRNVERARVLDGIAATKAKRGGKQGEDKADGEGPASGSGAAAGTDTGAQPDKRRTVFKQIPLADRKGDASSGGKPAGDVARVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKS4</accession>
    <name>A0A1B7YKS4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161069.1">
        <property type="nucleotide sequence ID" value="XM_018299823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKS4"/>
    <dbReference type="GeneID" id="28863930"/>
    <dbReference type="KEGG" id="chig:CH63R_04848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04848"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="226" mass="24326" checksum="8E3735C590DC3F71" modified="2016-11-02" version="1">MSPFPKKTPLDLGHSDVRTQFFFKVPNGVSQFLLFLAEISLSVEEVRTPNVNTPCCIETGLNELVTAGRAYFPSIDGSTGVSLPPAGLVGWSNICGAAGQMTFEGGGPSPGKDRHVDLETVQEIIGLGCRCAAMVPDLEGPSLGNSSPEAMSMPGTHLNITQRFYTWRGNHGPKKERGQWHQRPPCYDAGRSLVGSKYNQSADGLLSVWTSGRGPESTFEEPSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL22</accession>
    <name>A0A1B7YL22_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_05011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161232.1">
        <property type="nucleotide sequence ID" value="XM_018299986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL22"/>
    <dbReference type="GeneID" id="28864093"/>
    <dbReference type="KEGG" id="chig:CH63R_05011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05011"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601740" description="Amine oxidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="12">
        <location>
            <begin position="241"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="320"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="777" mass="87317" checksum="C3A414CF81608678" modified="2016-11-02" version="1">MYLRQLSLCLLAFLWAACEPAEAGRSTKPFANISTCDINGVAPKVKATKANVWSPISPGDNLAVWNLLHQPATGLNLTDPSKATITDNYVYWIDTLPTNKSNVLPYLHGAANPPPKYARVVIFRGGQEVPDSQEYMVGPLPVTADTRVEELDYIFNGGTGGNVPFNSRYFDAAREAATEPLLVSVMRNISDITSELIGGVYHGMGDNRTTLHTTSGTPMSYDGTQAFRTVMFRYPNAAAYLTPLDFFVMLDITGTDASRYRLRGIVTNERFFPTTAAIRAAWVEGGLKKQFKQTRNPDWAFLDYKSELGARDLEHKLAPQSLEIGGKRYKIDEEEKYIEYMGWSFYTSYSRTLGLMYYDIRFKGDSVIYELSLQEATAQYAGFTPSAAGTVYQDTHYSLGTNLGTLVEGYDCPFGSTFWNVTHHEGNSSVVNTDAICIFEADAGYPISRHRFEAENKYGFSYLGTVKASALTMRSIATVGNYDYMFDYSFHVDGSLEVVVRASGFIQASFYHPDQEQFGPRVQEATMGSLHDHVLTYKADFDIVDTKNSLEVSQLVLVNQTQPWYPELGFFEQMQLQKSTMKGEQQFNWQPNQAAMYCVVNPGANNSWGEKRGYRIIPGRSNIHLTSLDSPWTKHQSPFAKSHLALSRQHDNEPYANSHSNVNLPLKPQQDFLKFFDGESVENEDIVLWFNLGMHHFTRSEDVPVTLYNEAVSSIVFAPQNFHDRAQDGDLRNRRWISVNRTSGELRFDSYGVELPSQCRVEFSEPVLGIKKNEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLJ3</accession>
    <name>A0A1B7YLJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161369.1">
        <property type="nucleotide sequence ID" value="XM_018300123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLJ3"/>
    <dbReference type="GeneID" id="28864230"/>
    <dbReference type="KEGG" id="chig:CH63R_05148"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05148"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601785" evidence="3">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="409" mass="44715" checksum="7E4F85AE87D473FD" modified="2016-11-02" version="1">MYPITIVAAAVGLLSVPALASPVETRDVLAELQDRAMSALVESGAGNKRSSCNIFNARYRRDWFVIPHTVESFSSAEKKDYISAVQCMLTSPSKSDPEFAPGARNRYDDFVAVHINQTTKIHGTSCFFEDRDICRGILTLGPQGNFLTWHRYFVWAYEEALRNECGYKGSQPYWNWLKNQDDLTKSPVFDGSDTSLSGDGSFVEHNGSISGAGAIVLPSGNGGGCVTSGPFKNMTVNLGPVNPGMDGLEASPSGKLGYNPRCLSRDLSSYTASKWFTNENMVNITVGPASRSVELFQNELQGRFADGFLGMHAAGHFTVNGEASDLYSSVVDPSFFLHHAMVDRVYWLWQALHLWNAFEIAGTITINNRPASRDALKSDVLDLGVNAENRTIDDVLNTIGGSPLCYVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLM1</accession>
    <name>A0A1B7YLM1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GA4 desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161454.1">
        <property type="nucleotide sequence ID" value="XM_018300208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLM1"/>
    <dbReference type="GeneID" id="28864315"/>
    <dbReference type="KEGG" id="chig:CH63R_05233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05233"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="387" mass="43292" checksum="B290A2E40048F3C0" modified="2016-11-02" version="1">MALDKIASNLSKVSGSASLDSPRQVLGSFNYYNGSGIPALNDLTIIEGTSPDNKTYQLPVTDLRSLPTPLSSYTHEKHGFQIVRQPLPISPSPAAVHDHRVMTKEYYPSMTALLKKTLGARCAVVRKHSLRDIPDWAPVGMNPEIGFEIESLAPFSIAHSDYTPAGARGHFRAMKEPDWFVENDVTDGSTTAAERDEFFRLRRAIIDAEDRAVAEAGIGPEVVRGQRAQPRGGHWDWDGANYKGPRYAFFSIWRAWETVRRDPLAVMDMSRPVSRKVEYAPLTRTYRDRPGCVPFYYSQNALIRPLGWRRRRRDSGFEAGAHGDDDDDDDATGDGEPAWCYLSEQTPEEVYFLKFYDSEALVRRGKGQDDVQLLCRGGGDGADSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLW5</accession>
    <name>A0A1B7YLW5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_05210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161431.1">
        <property type="nucleotide sequence ID" value="XM_018300185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLW5"/>
    <dbReference type="GeneID" id="28864292"/>
    <dbReference type="KEGG" id="chig:CH63R_05210"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05210"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF87">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601761" description="laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="95"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="212"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="433"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR12914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="600" mass="66775" checksum="E002D08F9903914A" modified="2016-11-02" version="1">MKSTLSKSVLFFLYGLAVAAPSNSGPAKRQDQQQPSDPNPSDQGPKSCNTPDNRQCWVDGFDIKTAYEENIPETGVTREYDLVLTEHTTFKAGDGMDKNSAMLINGGFPGPNIKANWGDKIKVRVVNNLRTNGTSIHWHGVRMLNNNINDGVNGITECPIPPGSSKTYEWRAEQYGSSWYHSHFSDQYANGIAGTIQIDGPTSKNYDEDLGVFSLSDWYYKSADEIRSTFTAPAAVPASDNILFNGTNVNKNGGGTHSRVTLKKGKVHKIRLINMSVDNTFSVSLVNHKMTVTGTDFVPVKPFETDSLYLSVGQRYDVLIDANQDAGKAYWFNVSFPSNRLCGTSNMNKPAAIFQYEGSSASLVPKEAGSAVTDAQCQDKTDYEPIFSVDVDSTAFSKTQDNSLDVTVDTSRTANQQRVYWKVNGQDMDIDWDEPTLSYLAKNSTDYPNQYNVFEVPNNNDWAFWVVENLFPAPHPMHLHGHDFYVLGHSEPASSGRGDGVRFNPQTDTTKLNFKNPTRRDVTTLPGRGWLVVAFKTDNPGAWLFHCHIAWHLSQGLSVQFLERAKDIPNTVKIQDIDDMCQQWDSYSKKAPFKQTDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLY3</accession>
    <name>A0A1B7YLY3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161578.1">
        <property type="nucleotide sequence ID" value="XM_018296762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLY3"/>
    <dbReference type="GeneID" id="28860869"/>
    <dbReference type="KEGG" id="chig:CH63R_01787"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01787"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="251" mass="27533" checksum="CB21D7AC3DBAD449" modified="2016-11-02" version="1">MDEPAALSLEPAEKNFKDKTGQEKVKWLQTHALAAFPDVPIIEYWERGRSLNGWVNLISKLLTLITNSLKKRAGNIVKVFAKVVHAFNVGLWRFSDIVTDDINALADTGVFPEDTPLTELPRVKKVEKVADLSNESTVSDTTIMQYFDTAVDFLKQGLGVVPGLKKFNPRLNASISTVVEAFVSAGKDFATEWDKPDPAPPHDGSTPAIMFAQVQQLDGLGPVQDVTSGDEQKIVVIPPIKEVAPARLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ34</accession>
    <name>A0A1B7YQ34_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162579.1">
        <property type="nucleotide sequence ID" value="XM_018297763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ34"/>
    <dbReference type="GeneID" id="28861870"/>
    <dbReference type="KEGG" id="chig:CH63R_02788"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02788"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="404" mass="45905" checksum="4E64BB0EDDC584A5" modified="2016-11-02" version="1">MIIGMDITHSSIDSVLSQAVDSLEFPIHNGPLRANGYQTPARLTLQRVYDQVQGVPPTDANKPIEVPPGPPGKGKPRLLLMGQRRSGKSSISSVVFHKLPPNETLFLESTARIQKDSMASFMDYQVWDFPGQIDFFENPNFDMDAIFGEIGALIWVIDAQDDYLEAVARLNATVLNLQRFYPNINIEVFIHKVDGLSDDYKLDIQRDITIRIQDELSDHGFENAPVTFHLTSIYNHSIFEAFSKVIQKLIPQLGTLEAMLTNLCRTCRFEKAYLFDVLSKIYIATDSATADMASYEICSDYIDVIIDITEVYGSWPRSDSQRKRLEAEPWNAKVEDQVACNWAESCMVLHDSQRPIMLREVDRYLALVAIMKEDSYDRMPLVNMNVEAVVQGVTEFFEITKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR95</accession>
    <name>A0A1B7YR95_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_03296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163087.1">
        <property type="nucleotide sequence ID" value="XM_018298271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR95"/>
    <dbReference type="GeneID" id="28862378"/>
    <dbReference type="KEGG" id="chig:CH63R_03296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03296"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="721" mass="78237" checksum="E8441401CE817067" modified="2016-11-02" version="1">MIEFRSQILPHSKAPDFKEAYDAAMDSTPVLNQGWGYGLMIGLGVLFAVIMIIITWALKRYNYELQTSEMFTTAGRSLKSGLHTWLLIYARQEAHLEQVASSVLSTWTWAATLLQSTAVAYKYGVSGPVWYASGATVQIILFATLAIELKRRAPNAHTFLEVVKARYGPVTHAVYIVFCCFCNILVTAMLLTGGSAVIQNLTGAPVAASVFLFPIGVVVYTLFGGIKATFITDYINGLVILVIIFIFAFTVYSTNELLGSPGKVWEILTDLAAERPLSGNSGGSYLTMRSQGGAEFFIINLCGNFGTVFLDNGYYNKAIAASPIDALPGYVMGGISWFAVPWLTATTMGLAGLALEKYDVWPTYPNRLSPADVDAGLVLPTAAVALLGKGGAVATLILALFKFMAIMSTYSSELIAVSSICTYDIYKTYFNPSATGKQLMRINYIGMGVFALLMAGFATGLNYVGISMGYLYLMMGVIISSAVLPATLTLLWDGQSWAAATFSPIIGFALSMTAWLVTTKIKYGELSVTNTGANEPMLAGNLTSLLSPVLFIPLLTFVPPFRPQGYDWQSMLNIRQAEDHDVAGAADADVENVPEAPIEPFADPDEKAKLDKAAKTARWLTVGVTLILLILWPMPLYGTGYVFGKSFFTGWVVVGITWLFASVIMVVFLPIFESRSTIVRTTRLMFKDLLGMRGRGKPVTEGQPQGSRTPPEVAEKIQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRG9</accession>
    <name>A0A1B7YRG9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectate lyase</fullName>
            <ecNumber evidence="5">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_03362</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163153.1">
        <property type="nucleotide sequence ID" value="XM_018298337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRG9"/>
    <dbReference type="GeneID" id="28862444"/>
    <dbReference type="KEGG" id="chig:CH63R_03362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03362"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000036">
        <property type="entry name" value="Pectate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601858" description="pectate lyase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="331" mass="34878" checksum="0900624A9B6CE5E6" modified="2016-11-02" version="1">MKFSNMLNLALVGFVSAAPTPTVDDEVTGVLAKRASITESCNIGYASTNGGTTGGKGGSTTTVSSLAQFTKAAESSGKLNIVVKGSISGSAKVRVASDKTIVGQKGSKIVGAGLYIKGVKNVILRNLAISKVKDSNGDAIGIESSTNVWVDHCDVSSDLTSGKDYYDGLIDITKGADFITVSNTYLHDHWKTSLVGHVDTQTSDKGKLRVTYANNYWNNVNSRNPSVRFGTVHIYNNFYNKIGSTGVNTRMGAQVRIESSVFENSSKKVILSADSKETGYATVSDMSYGGGENSAPLGDFGSSKVPYSYSLYGKSNVKSKVVGTAGQTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSD2</accession>
    <name>A0A1B7YSD2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxopent-4-enoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163464.1">
        <property type="nucleotide sequence ID" value="XM_018295102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSD2"/>
    <dbReference type="GeneID" id="28859209"/>
    <dbReference type="KEGG" id="chig:CH63R_00127"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00127"/>
    <dbReference type="OrthoDB" id="4391601at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008684">
        <property type="term" value="F:2-oxopent-4-enoate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050772">
        <property type="entry name" value="Hydratase-Decarb/MhpD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30143:SF0">
        <property type="entry name" value="2-KETO-4-PENTENOATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30143">
        <property type="entry name" value="ACID HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="261" mass="28409" checksum="F453DB8E11A8194D" modified="2016-11-02" version="1">MQDSDLREISLALRTARINKEPIGPPTKRWTALDADTAFEVQKITVENAISQDGDRLVGYKLGNIAKVMQDAFGLDQPDYGFLLASTFIYEGTALNRKDFIKPYVELEPAFVLKGPLKGPNVTVADVINAVDYAIPAIEIIDSRVQDWAIDLPDTLADNGSTGAVILGGTPRRLTDLTLSNTRGTLQFNNREVMSGNTRNVLGNPLSAVAWLANKLSKYDVGFTAGQVILPGSCLQAVPMVDSGRWSCTFEGWGTIEFDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YT89</accession>
    <name>A0A1B7YT89_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163777.1">
        <property type="nucleotide sequence ID" value="XM_018295415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YT89"/>
    <dbReference type="GeneID" id="28859522"/>
    <dbReference type="KEGG" id="chig:CH63R_00440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00440"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="643"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="690"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="825"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="748"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="960" mass="106557" checksum="C59CC1959DB68D71" modified="2016-11-02" version="1">MVKSYLKYEHSKSFGIVASNTSNLVWAPLGRAGSGTGQAIVAANEDVLCWDIKKGELLSRWRDERNNVPVTAIAQSKVDTDVFAVGYEDGSIRLWDSKIATVIVNFNGHKSAITTLAFDKSGVRLASGSKDTDVILWDLVAEVGQFKLRGHKDQITGLQFVEPEGQVEDEENMAMLDSDPSAEGYLLTTGKDSLIKLWDLSSRHCIETHIAQTNGECWALGLSPDYSGCITAGNEGELKVWFLDTTALAALKGQVDAPQDTKFLHDRGTLFRQHKDKAVEVVFHPRRDYFAVHGTEKAVEVWRIRSEAEVKKSLARKRRRRREKAGKEAKEVGDGAAEGDEQADDISTAEASDFFIRYVIVRTGGKVRSVDWAVNGGSKEVHLLAGTTNNQLELYSIPTKEGSKSKKEDVPEYTRSLAVELPGHRTDIRAVSLSSDDKMLATAANGSLKIWNIKTQACIRTFECGYALCCAFLPGDKVVVVGTKTGELELFDVASASLLDSVSAHDGAVWSLQVHPDGRSVVSGSADKSAKFWDFKIVQEEVLGTTRTTPKLKLVQSRTLKVSDDILCVRYSPDAKYIAVSLLDNTVKVFFTDSLKLYLNLYGHKLPVLSMDISYDSKLIVTSSADKNIRIWGLDFGDCHKALFGHQDSILQVAFVPHNSDGNGHHFFSSSKDRVIKYWDGDKFEQIQRLDGHHGEVWAMAVGHTGNFLVTAGHDKSIRVWNETDEQIFLEEEREKEIEELYEKTLTTSLERDQDAEDQDGEVGAASKQTVETLMAGERIAEALEIGIADLSLLKEWEDAKKSNPHAPAPQRNPIFLALGNITAEAYVMSVLSKIRASALHDALLVLPFSTVPMLFTFLDLFAQRSMNIPLTCRILFFMLKTHHRQIVASRTMRGMLDGIRANLRAALKRQKDEMGFNIAALKVVGMQIQEKSVKDYVDENWDGGDDSRTVKKRAFVQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTX2</accession>
    <name>A0A1B7YTX2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_00680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164017.1">
        <property type="nucleotide sequence ID" value="XM_018295655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTX2"/>
    <dbReference type="GeneID" id="28859762"/>
    <dbReference type="KEGG" id="chig:CH63R_00680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00680"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="383" mass="42370" checksum="696BA7ABD480976F" modified="2016-11-02" version="1">MASFFDLKARKAAAANGTAVQKQDKSAQPPRAQPWVEKYRPKTLGDVTAQDHTVTVLQRTLQASNLPHMLFYGPPGTGKTSTVLALAKELYGPEMMKSRVLELNASDERGISIVREKVKDFARMQLTNPTNDYKKRYPCPPFKIIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQGNAKKRLEDIAENEGVQLEDGALDALIKCSEGDLRKAITFLQSAARLVGAGDKDASRDDAMDIDKKPVTVKIIEDIAGVIPENTIDELVSSIRPQGPGDTYQNVAKVVENMVADGWSAGQVVTQLYQAIVYDETVPDVQKNKIVLIFSEVDKRLVDGADEHLSILDLALRISGVMSGRSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU39</accession>
    <name>A0A1B7YU39_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164083.1">
        <property type="nucleotide sequence ID" value="XM_018295721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU39"/>
    <dbReference type="GeneID" id="28859828"/>
    <dbReference type="KEGG" id="chig:CH63R_00746"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00746"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="149" mass="16562" checksum="0A2280244EFE3E06" modified="2016-11-02" version="1">MAFHEGITAELNTRYNAPRVRTVLVNQGYTKTPLFTGYQQGVEFILPALEPETVADAIVKQVLSGESGQIVLPAYGNMLTALRAFPHWYQHKLRGESKKLMANFSGRQVVKDVEGFYQKRGKGVEGEQERPEESTVLVAEPIPGRSGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUS3</accession>
    <name>A0A1B7YUS3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164304.1">
        <property type="nucleotide sequence ID" value="XM_018295942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUS3"/>
    <dbReference type="GeneID" id="28860049"/>
    <dbReference type="KEGG" id="chig:CH63R_00967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00967"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="140" mass="15172" checksum="72FF2535B3EB0E0C" modified="2016-11-02" version="1">MNVRRPSSGISSRATGLDPDGTPSAPTADCPPDPRPAGMASRFATVKPVSQRRNAGMPTRVAAQRCLFLDPGEATGTQNMYVKPVRRWGGISYPPTGSPHHNPPKRSDAQDPISLRPFSHSPSRLLAASSRVTTRWRMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUW9</accession>
    <name>A0A1B7YUW9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164195.1">
        <property type="nucleotide sequence ID" value="XM_018295833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUW9"/>
    <dbReference type="GeneID" id="28859940"/>
    <dbReference type="KEGG" id="chig:CH63R_00858"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00858"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053136">
        <property type="entry name" value="UTP_pyrophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YGJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399:SF1">
        <property type="entry name" value="UTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="459" mass="51312" checksum="821713798323D464" modified="2016-11-02" version="1">MKEHHLSVMSLEEYEPNREFVGRNFNAGEIIQLVLKSRSGRWLPFEYVQMVMMHELAHCKQMNHSRAFWAVRNQYADLMRGLWQRGYSGEGIWGRGAQLGTGQFQNNVALPGEPLPEHLCGGTYRSRGRKRKIKPKLSYKEQKERRIFKKFGANGVALGADEETKVKLEGGKRTQAKPRVAGSARGRELRAAAALARFDKVKEEPEDEIKFEVKDEDDSGESEYEDDPADVKNEDAIDIDGKPITDGKGRGMIKVCEDENPDDQDAQNELQELRNSVQRWRQTHLNFKRENDSAEMTASRNRSRQPEEPTSHAPRQVVQPRVKIKKEEDDADGEEPILNTASAIPTIKREAEDAHRLPSSYRLISPNSAASPSDKDGATQPVTTSITRAPGSAEVCGICSFANPVLSITCTMCSHVLDPASVPNAWRCRSTACQGSEYLNPGDFGVCGVCGQSKKQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUY5</accession>
    <name>A0A1B7YUY5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164374.1">
        <property type="nucleotide sequence ID" value="XM_018296012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUY5"/>
    <dbReference type="GeneID" id="28860119"/>
    <dbReference type="KEGG" id="chig:CH63R_01037"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01037"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="91" mass="9645" checksum="AF3B702E58EDA50B" modified="2016-11-02" version="1">MTASNNSRRAPRACAAAAAAAHRPPTPPHPDGPFQASLTKKQLSVPALGILNHIGFHLISMPKKRAGRVATPRDPQANHRPMPSTSIEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWK8</accession>
    <name>A0A1B7YWK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164859.1">
        <property type="nucleotide sequence ID" value="XM_018296497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWK8"/>
    <dbReference type="GeneID" id="28860604"/>
    <dbReference type="KEGG" id="chig:CH63R_01522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01522"/>
    <dbReference type="OrthoDB" id="4851731at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="580" mass="60661" checksum="AEE4F9562948C63E" modified="2016-11-02" version="1">MEGTAAIWSNLRQRRRRPGPKFPGRPRHNLVRRQEPAPPAAPPAEEEEGGEADGEQEEGGGDQEEEEEEEEEEGEEAEPVGQEEEEEGEKEDEAEGANGQEAESESDAEGPAGASSESESDAAPPGQQADSSDSEQEQPPPAVSPPPPAATPAPPPGVQPPPAASSLPPPAAQGSPEPQSPAERPVAVLNPSRPSDLPASIPPARGFITLVPGAPAPLNPPQPPAPPPPPPQESPARQPQPPPAATPSNPPVAEPQNPPPASQPSTPPSPPTPPSPPAEQPPTPPAAETPSTNLPPPAVENAASGTPRPGLLPPNSQAEATNGPISATPAPAEGTDRGFAIGIAFAVVAIVALLIGATIFGVKRYKRKKKVAAVATNMGQNPGGGGGGGNAFFPRESAILRQPKRNTREVEQAIVATFRQTKIANRTTREMEEQMVAQFRTERNTMTSQPNAPAAVAVAAAATPPPVPDAAAAAGNFNARNMQAESFYYERSINEPVMPAPLRISTSQRRPATQSTRAPYPVSTYDMYQEVGQGPYRESINIGFQPYNPDSYYFPPQPGGLPRAERGADGRFVPETRYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YX07</accession>
    <name>A0A1B7YX07_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha beta hydrolase fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165096.1">
        <property type="nucleotide sequence ID" value="XM_018296734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YX07"/>
    <dbReference type="GeneID" id="28860841"/>
    <dbReference type="KEGG" id="chig:CH63R_01759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01759"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="58772" checksum="B83774E476891D7B" modified="2016-11-02" version="1">MLVGKSVPELILVRSMVIFFQYLGLGCFLYFWFIFAIAGVPGIAHPVSIVIEVVGAIEILFYLVWFIPYRSRLQKPGPQPTPLSRDERRRFFYDGLDHVPDVEQYIRKWHCNAQLGDIRRENLKDWLLWALFDKQGHPAEHEEELEEYIADAEERAGVTIKGGFGDSAPMRLSFDPIEITHRSLLFYLITGSLDFFATLVLFIRGFKFYRQPRSTFFSVFPWRPMTLLSPNESADPRLSYFCRPHTSTTQRPILFMHGVGMGMLPYLLWLWSIPKDVGVLAIEILPVSSRICPPLQTTKELVDGIDAIIMQQAYTDFVFAGHSFGTLLASPLLKRPDIAARINSIVLIDPVSLLLHLPAVAYNFTRRRPRWGNEWEIWLVATDPMVAHTLARRFRWQDFILWTPQLQGKRTTVVVGGEDCVTDPSAVASYVYFGDLNYTRHDKLEWATTPERWTGRGELELMYLDGMDHGQAFLSVKHMPQIGNVVLAYTHLKGTMESRQADAAKEEELNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVI9</accession>
    <name>H1UVI9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04461</name>
        <name evidence="4" type="ORF">CH63R_12158</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000289">
        <property type="protein sequence ID" value="CCF31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153973.1">
        <property type="nucleotide sequence ID" value="XM_018307132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVI9"/>
    <dbReference type="STRING" id="759273.H1UVI9"/>
    <dbReference type="GeneID" id="28871239"/>
    <dbReference type="KEGG" id="chig:CH63R_12158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12158"/>
    <dbReference type="eggNOG" id="ENOG502T4BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121519_0_0_1"/>
    <dbReference type="OrthoDB" id="4851284at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555967" evidence="2">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="22522" checksum="7CAE6728BCBA1FBA" modified="2012-03-21" version="1">MKFSTTAFLALGFLAGNVLSAPAFQSNDVAIPVEIRAEGSVANDAAHLEARARKKQGAGKVGAKGQGAAAAKAQVAKKKKNGAAAAAKKKDAAKEKATAAKKKTEEAAKKKNDAAKKQTEDAAKNNNNNANNNNDNNNANNNANNNANNNANNNANVGKGKGKSQAEFQGLACTDGKGAGSCNANGQCAVNGKTAEIAGQCGVAAAAKKAATKRYVSGKARII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWD8</accession>
    <name>H1UWD8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_04706</name>
        <name evidence="2" type="ORF">CH63R_04078</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="202" mass="22524" checksum="AC48348269DB7E13" modified="2012-03-21" version="1">MSAKTESTTKKFGSSTRVVPAPSQKAQKWYNADDEPEAKKVRKAVRPWAPRKTLQPGTILILLAGRFRGKRVVLLKTLDQGVLLVTGPFKINGVPLRRVNSRYVIATSYKVDVSGVDSQKIEEISQPKYFTADKAKKQNGEDAFFKQGEKPQKKEINSSRAADQKAVDKALLASIKKVDMLASYLASSFSLRKGDKPHEMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWT6</accession>
    <name>H1UWT6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_00803</name>
        <name evidence="8" type="ORF">CH63R_10873</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02000424">
        <property type="protein sequence ID" value="CCF32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155271.1">
        <property type="nucleotide sequence ID" value="XM_018305847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWT6"/>
    <dbReference type="STRING" id="759273.H1UWT6"/>
    <dbReference type="GeneID" id="28869954"/>
    <dbReference type="KEGG" id="chig:CH63R_10873"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10873"/>
    <dbReference type="eggNOG" id="KOG2524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036001_2_1_1"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="366" mass="42157" checksum="CB854FC4814954A6" modified="2012-03-21" version="1">MSDDEADPELLALLRQHFQGKLNIDNEPETGVLEGAEFVYDNSIDVAIDMRSTKRAAATIYAQMEQKQYSTSTWAEHELHPKTKDEATAAFVFTMDLLNFCFWSEKPDDERFAVEYRGRTWTGYWSMVASLQRALDEDIPITSPDFWQSEDECTMELMRHVFRSKTDEEMPLLEERLACLREAGTVLYERYNCSVTKLIEAANGSAARLVNLLARDFDCFRDEHKFEGRRKPVRILKRAQILVADIWACFGGEGIGAFRDIDKITMFADYRVPQILNTMGCLYYSPSLATAIVDKRVIESGSRLELQMRACSIWCVELIKREIQREHPGTSVNAILIDFFLYDTMKELEAAGTETVGHHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX89</accession>
    <name>H1UX89_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00832</name>
        <name evidence="3" type="ORF">CH63R_00603</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H1UX89"/>
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    <dbReference type="KEGG" id="chig:CH63R_00603"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00603"/>
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    <dbReference type="OrthoDB" id="4832308at2759"/>
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        <property type="component" value="Chromosome 1"/>
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    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15423.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="150" mass="16860" checksum="3FD97BEA5F6B402E" modified="2012-03-21" version="1">MTSNKEDQESVRNAPPADHRPSTTSAFTALPLEVRKQNTTAPRPYRPSDILIFSPSPLAADITIVRMAREAASLPSPRLRHNIPQQRQLSIRPKPSPLAAAQKRPRILLSTKNFKWVKTCDALWVKVPVASKKQRIVLKMKGKKARTPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
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    <name>H1UXU0_COLHI</name>
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        <name evidence="8" type="ORF">CH63R_02440</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162231.1">
        <property type="nucleotide sequence ID" value="XM_018297415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXU0"/>
    <dbReference type="STRING" id="759273.H1UXU0"/>
    <dbReference type="GeneID" id="28861522"/>
    <dbReference type="KEGG" id="chig:CH63R_02440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02440"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_4_0_1"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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        <property type="entry name" value="SKP1"/>
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    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
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        <property type="entry name" value="SKP1-like_dim_sf"/>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
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    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="170" mass="19885" checksum="8F4730A0A2E091AE" modified="2012-03-21" version="1">MAAEKKDSKIWVQSNDNITIPVDRVVAERSMLIKNMLEDVGDDSISQENPIPIPNVNEAVLRKVIEWCEHHRNDPVQTQDDENDARKKTTEIEEWDQKFMQVDQEMLFEIILASNYLDIKPLLDVGCKTVANMIKGKSPEEIRKTFNITNDFTPEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZP3</accession>
    <name>H1UZP3_COLHI</name>
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        <submittedName>
            <fullName evidence="6">Transcription factor SPT8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_05638</name>
        <name evidence="7" type="ORF">CH63R_07663</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
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                <person name="Miyara I."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
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                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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    <reference evidence="3" key="3">
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    </evidence>
    <sequence length="599" mass="67408" checksum="BA142126B8A1684B" modified="2012-03-21" version="1">MDYENSSPTSHSARYKPLVDADLETEPGELRWALRCVTVAPGHGSEPVRCKLVDFTLGRAQQTYEALSYTWGDRMDQATIHLDDKPLDVTKNLETALRCLRRPRAERLLWVDAICVDQSDVAEVNLQVQRMWAIYQYASRVVVFLGEEKADSVQAVALVEAIAKDVKVGDYDRITSMLNVMKAKSSRLALQRLMRSPWWSRAWVVQEFSVAAAVVFVCGSVEMSSEVFGKALEVLLDYRFNAVIPPRQEYFMREIAATPISHLWTARKEYQATKPTLPKRVPLSLLYRFRGFGASDPKDKVFSLFHIMGEIAALRPDYTRSVRDLFKDIVRTSIELSDGLQILCHHNRMGKSTLDLPTWCPDWSIKRGQRILLWQNGYTAGGDSKPVARFEEDKLWLQGKLLDRIQWLVSFEPKVFRNKGLLFDQIKTIEARIVQQGISQRGEGASSVPSLESFHRTIVGSRVRERGPQHGAIVLGECDAEMYWDAWHEQMIAAPHDALHGKAKVYNDAIYSALAGRSFFATEKGHIGLADNPADAGDVVGVFPGSRVLFCLRETTSRPPRAVGGSEDRFELIGECYLHGFMDGEAASGDEDTSSLCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4T0</accession>
    <name>H1V4T0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_07063</name>
        <name evidence="3" type="ORF">CH63R_09064</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001454">
        <property type="protein sequence ID" value="CCF35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156061.1">
        <property type="nucleotide sequence ID" value="XM_018304038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4T0"/>
    <dbReference type="STRING" id="759273.H1V4T0"/>
    <dbReference type="GeneID" id="28868145"/>
    <dbReference type="KEGG" id="chig:CH63R_09064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09064"/>
    <dbReference type="eggNOG" id="ENOG502RUV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037358_0_0_1"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497584" evidence="1">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="452" mass="49209" checksum="B26B7D9066092396" modified="2012-03-21" version="1">MAGRLLSLTLGVLSLIATPAVAQDGSTSHITLSNTEDVTFLSGTRTIPVTQPRTPTGPYATYTSRITLTNGDLSTMTGTMTFTGNVTQTTTNSVGQSVVIISGQTSVVTSTVTGNSTQTTTSAAGPTNTQPCNNYVEFCDRKYSNITEVGCHNSPFVRPGNSASNQALDVTTQLNDGVRFLQAQIQWPTNGTKPHFCHSSCDILDVGPITEWLTTVREWVAAHPYDVVTILLGNGNYSTPDLYAPFIESTGILQYAYEPPFLPMTVEDWPTLSQMILGGKRVVMFLDYMADQQKFPWLLDQFSQMWESPFDPMDRTFPCTVQRPPDLPDEAARDRLYLMNHNLNAEYNIFGASILVPAVSLLNETNNVTGYGSLGVSAQQCTDQWDRPPKILNVDYYNYGGYPGSVFEVQARMNNVTYTRDCCGKVTGASPGRPAASAMVLGMALACALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4X4</accession>
    <name>H1V4X4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07097</name>
        <name evidence="4" type="ORF">CH63R_12161</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001470">
        <property type="protein sequence ID" value="CCF35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153976.1">
        <property type="nucleotide sequence ID" value="XM_018307135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4X4"/>
    <dbReference type="GeneID" id="28871242"/>
    <dbReference type="KEGG" id="chig:CH63R_12161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12161"/>
    <dbReference type="eggNOG" id="ENOG502T49R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1695343_0_0_1"/>
    <dbReference type="OrthoDB" id="4846777at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497586" evidence="2">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="155" mass="16676" checksum="66CC4B4957A8962A" modified="2012-03-21" version="1">MRFTFAFLLFLLTLTVALPAAKEKSSSTKTKLVKGIENNLKHGDKEIKATKQAQDEAAKGNDKQVKKKEGKINDALDAAIKDRKGNQKLAGNKDPALTKGLGKVENAQKGAKKTVGGLTGDSKKDKAALGQLGATFEKGKKTNTQNLKEAKKNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5D5</accession>
    <name>H1V5D5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07223</name>
        <name evidence="9" type="ORF">CH63R_14059</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001536">
        <property type="protein sequence ID" value="CCF35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151351.1">
        <property type="nucleotide sequence ID" value="XM_018309033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5D5"/>
    <dbReference type="STRING" id="759273.H1V5D5"/>
    <dbReference type="GeneID" id="28873140"/>
    <dbReference type="KEGG" id="chig:CH63R_14059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14059"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_1_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="491" mass="52232" checksum="DA25948083F49DBD" modified="2012-03-21" version="1">MPSDPTAAAAEPAPSSILIIGSGVFGLTTAYELAQRPRYASTAITVLDRSPVPGPSEDAASVDSSRIIRADYADPAYARLAAEAQTEWRKTENPSDLGAEGRYSQSGLCLVADPTPTASSAYSSSPSPSSETVNTNAQAKQKAKKTSLEYVRESYNNVVSLAGRDGDKIIKELPTPTAIKGFLGTPIAPGTWGYINPLAGWADAGAAMSYLAAKVQALQRVRFASGTATHLNYSSDRTTVTGATLDDGSVLSADLVIVAAGAWTGQLVDLSGQAIATGQAVGYIDITPSELEVLRKMPVTLNFSTGLFMIPPAGLQLKVARHAFGYLNPTPIPHPSPLSPSSARSTVSLPATHLTDPRLKFPKEGEAALRQAVRTIVPIPAIHDRPFVQTRLCWYTDTQSGDFLVCHHPEAKNLFVATGGSGHGFKFLPVLGREIVNVLEGHGDEVFTEKWRWREVASKANATNLYEHIMTEDGSRGGIPGLLLKQEQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5G9</accession>
    <name>H1V5G9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_07251</name>
        <name evidence="12" type="ORF">CH63R_00105</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02001552">
        <property type="protein sequence ID" value="CCF35471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163442.1">
        <property type="nucleotide sequence ID" value="XM_018295080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5G9"/>
    <dbReference type="STRING" id="759273.H1V5G9"/>
    <dbReference type="GeneID" id="28859187"/>
    <dbReference type="KEGG" id="chig:CH63R_00105"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00105"/>
    <dbReference type="eggNOG" id="ENOG502SJT6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_0_1_1"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554594" description="Glucanase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF35471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="431" mass="47013" checksum="3C63E13A922C1934" modified="2012-03-21" version="1">MAPTFSSRLGLAATTLFFLGLTTAQRQIGPVENHPPLTTWRCTKAGGCTEVNNFVVLDSLAHNVYQEANGASCGSWGNPPNATACPTKEACAENCVQEGLDDYSRVGVSTDGGAMTMYQLRNGAQVSPRVYLLDPSKERYEMMHLTGKEFTFDVDVSRLPCGMNSALYTSEMEADGGKSELNKGGARHGTGYCDAQCYTTPFINGEANIEGYGSCCNEMDIWEANSRAVHVAPHPCNQTGVYLCEGEECAFEGVCDKNGCAWNPYRVNTPGTYGRGPEFKVDTTRPFTVITQFPADAAGVLTEIHRLYIQDGRLVRSEVVNNPDLPQVNYLNDEFCEATGSRRFMDLGAHREMGESFNRGVVLAFSIWWDAGGGMRWLDGAPEAGPCDATEGFPENVVKVEPNPVVTFSNIKWGELGSTFKPTCKNKPRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5X4</accession>
    <name>H1V5X4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_07366</name>
        <name evidence="10" type="ORF">CH63R_04351</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001620">
        <property type="protein sequence ID" value="CCF35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160572.1">
        <property type="nucleotide sequence ID" value="XM_018299326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5X4"/>
    <dbReference type="STRING" id="759273.H1V5X4"/>
    <dbReference type="GeneID" id="28863433"/>
    <dbReference type="KEGG" id="chig:CH63R_04351"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04351"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_1_0_1"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="46"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="242" mass="27128" checksum="96952C0F6E8AB0D7" modified="2012-03-21" version="1">MSSASSTLPPDLFDQTTLVSLGATVVLLSIAIAVSRRVLHPTTSTRYRVLFVWHAFDALIHFFLEGSFLYHCFFSYIPLADVPNADLGGFHPTPANFLGHSDRIYGAQAGGDNPFAQLWMVYARADKRWAGADLGVISLELLTVFGAGPLAVWICYCIAKRDPKVNIWMIIIATAELYGGFMTFCPEWLTGNIYLDTSNFMYLWVYLVFFNMLWVFIPLYAIYVAYGEISSAFKVQGARKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1V635</accession>
    <name>H1V635_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium calmodulin-dependent protein kinase type i</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_01357</name>
        <name evidence="8" type="ORF">CH63R_01248</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001646">
        <property type="protein sequence ID" value="CCF35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164585.1">
        <property type="nucleotide sequence ID" value="XM_018296223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V635"/>
    <dbReference type="STRING" id="759273.H1V635"/>
    <dbReference type="GeneID" id="28860330"/>
    <dbReference type="KEGG" id="chig:CH63R_01248"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01248"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="422" mass="46549" checksum="1BAE4439C4B73286" modified="2012-03-21" version="1">MASNGSNGASQQPQVQPCRYKVGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKKVSMGNQNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGSYFESDAADLVRATLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKIGHGKPVDVWAIGVITYFLLCGYTPFDRDSDFEEMQAILNADYSFTPFDYWRGVSDHAKDFIRRCLTIDPNKRMTAHDALQHPFVAGYLNNGEGEGQNLLPTVKKNFNARRTLHAAIDTVRAINKLREGQANLMDGAKSQEPTRGAAALKTQPNTRKDDSAISISSQGDKDSGYGTQPEADSQTDVVMTDAGPTLSGVPASLRPGSEQNKVVETSRGLWSGSALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6X0</accession>
    <name>H1V6X0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_07643</name>
        <name evidence="15" type="ORF">CH63R_09342</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF35972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR07821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018304316.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V6X0"/>
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    <dbReference type="GeneID" id="28868423"/>
    <dbReference type="KEGG" id="chig:CH63R_09342"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09342"/>
    <dbReference type="eggNOG" id="KOG2340">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="UTP25"/>
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        <property type="entry name" value="UTP25_NTPase-like"/>
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    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
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        <location>
            <begin position="277"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="545"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="54"/>
            <end position="64"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="65"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="157"/>
            <end position="183"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V951</accession>
    <name>H1V951_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GMP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_08247</name>
        <name evidence="2" type="ORF">CH63R_03406</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
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                <person name="Sykes S."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002985">
        <property type="protein sequence ID" value="CCF38460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164606.1">
        <property type="nucleotide sequence ID" value="XM_018296244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VE07"/>
    <dbReference type="GeneID" id="28860351"/>
    <dbReference type="KEGG" id="chig:CH63R_01269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01269"/>
    <dbReference type="eggNOG" id="ENOG502SQFA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050395_0_0_1"/>
    <dbReference type="OrthoDB" id="5242916at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="342" mass="38491" checksum="486459C362257C97" modified="2012-03-21" version="1">MATLAAFSLFSNLPVELRLNIWEETVSSPSIHVFDVCFPSRRGNDRSERAFGEASSASHQSQSVRWKRYKNSVFLDSLEVTTGDDQLAGPEPRPVQHVQDPSVYRQRRALHLTCREAFSSSALRTNKVNTVYLPGRGRKFEYDNDRDVIFLRFWGSDRPIGARSTSSEQVNSSVSSITEVLEACWSAEMALTVYQALRIAIDVDEMTMRLCIGEVACLASCFQKGLEVLYLVDHQTGDGGSDTRYRHVAADLQNRGGLYRQLHSGILRENLTRVPDLIRGVGRAYREVFDLERLSWGESHPAYIFARLVTDSIRNQQLDAGAAEFKGVRILVVEDEGVYTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL64</accession>
    <name>H1VL64_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02479</name>
        <name evidence="3" type="ORF">CH63R_10263</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004412">
        <property type="protein sequence ID" value="CCF40967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154661.1">
        <property type="nucleotide sequence ID" value="XM_018305237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL64"/>
    <dbReference type="STRING" id="759273.H1VL64"/>
    <dbReference type="GeneID" id="28869344"/>
    <dbReference type="KEGG" id="chig:CH63R_10263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10263"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_0_1"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="71" mass="8058" checksum="CD5A10845A1ABF96" modified="2012-03-21" version="1">MVFAWKAAGLTYNRYLAVASRVVRRSLKEDKRIIAERRGGTELRFAKWENGKQNEPKLLSQATVNVPPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VMA5</accession>
    <accession>I2G7H2</accession>
    <name>H1VMA5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">EC91 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Hypersensitive response-inducing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11667</name>
        <name evidence="3" type="ORF">CH63R_13082</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004685">
        <property type="protein sequence ID" value="CCF41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018301546.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VMH1"/>
    <dbReference type="STRING" id="759273.H1VMH1"/>
    <dbReference type="GeneID" id="28865653"/>
    <dbReference type="KEGG" id="chig:CH63R_06571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06571"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005092">
        <property type="protein sequence ID" value="CCF42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164567.1">
        <property type="nucleotide sequence ID" value="XM_018296205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VP63"/>
    <dbReference type="GeneID" id="28860312"/>
    <dbReference type="KEGG" id="chig:CH63R_01230"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01230"/>
    <dbReference type="eggNOG" id="ENOG502SSSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008355_0_0_1"/>
    <dbReference type="OrthoDB" id="4812032at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="276" mass="30745" checksum="8E16AD38734C5697" modified="2012-03-21" version="1">MVTSRKRTNPEPEAKLSCDAEPASLVNFNDTPPSPADVITLPKEDDDLEALIGKLGALADVVSRNRSLALWTGFAATPNPKRDPIDIAKAEADPRELEMFAMFDRNGRRLPESSAAQFDVTRDVKPLVRENVKTAARYEDMASCVDEVFGTRGATKENVCWIVENMEVVLPLVKFHLRVKRARRNLSGGLETLTSNELAEYQTVRKIRSVLGVRMQKCRVGGRCSNKRLSGYDAVLLRRQNIMSCLVKGQRESQMRTGGVRGESGQLRVKRQRCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPV1</accession>
    <name>H1VPV1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_02786</name>
        <name evidence="7" type="ORF">CH63R_13267</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005257">
        <property type="protein sequence ID" value="CCF42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152658.1">
        <property type="nucleotide sequence ID" value="XM_018308241.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1VPV1"/>
    <dbReference type="GeneID" id="28872348"/>
    <dbReference type="KEGG" id="chig:CH63R_13267"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13267"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000022_60_4_1"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
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        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
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        <property type="entry name" value="AA_adenyl_dom"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="CAT-like_dom_sf"/>
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        <property type="entry name" value="Condensation_dom"/>
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    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
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        <property type="match status" value="4"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
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    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="8"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
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            <end position="1203"/>
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    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2693"/>
            <end position="2766"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1224"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1223"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="3230" mass="357967" checksum="03975200E692E8E7" modified="2012-03-21" version="1">MSSGTGISDTSVVTEKLRTLVSKLLAIPLENVDAEASFVGLGGDSFKAVHLYQRCADQGLAVRFQDILHKPLIDIASLAESCLANGSDDATGRHRDDGDEKYPQMPFNYDFSKIYSELEEKYGLTSEDVETIYPCSPMQESMYIGQKMSSKRLYRTRGLFEAQSEFDPSSFEAAWNDVVRRHQTLRTVYVETPGPASERLLDAVVLKKRMGKMTTRQVDDVADAKHRFAVGDLENEDNDTEESHHRITLYNTTRGTHRTQTLLQVDLNHLTVDGTSLMILMDELVKRLQGSQIAGPAPGYGRYIDYLQNQADESAALDYWIEYLDGAEPSYFPTMNDKKSGSAGSFEVVEIPLDTISLDSLRAVCRAFNATISNALQAVWALVLSTYTGDPDVCFGYLSSGRSLPIPGVSEIIGPMMNLLVCRVGGIEGKSLGGLLESVRDDFVNALPHQCFSIGKVQRILGTNETKLFNTIMTSYYSPSMSSSTDSGREFFKLVASHNASDFDLVLKVTYSDSDIRVRLAYSTAILSPSMAENVSHTFSSILGRLIDTQDPDTRVQRVTSISPWDLDQVTAWNHRNTASATRPVPVHELIENQALLRPEAPAIYACDGEMTYRELDEASTAVARRILALGIGPGAFVALCFEKSIWYSVAMIGVLKSGNSFVPIDVSNPTSRREEILQQLGISALAGLIVCSRDQAPSLRPFSRHLLELDGETLAHIASADCSSSLPSASLTDPAYIIFTSGSTGKPKGVVVQHGAYSYAAQAHSPGIHINEDSRVLQFASYGFDTSMEDHLTTFAVGACLCVPSEEDRLNLQNLASFTSKSGANWAHLTPSFAELLTPTLMPTMKTMVLGGEAMTARNIRNWAASPDTELIQVYGPSECCVTSTISPALSLYSDPTNIGSAVPGCRTWIVRPDDPNALQAIGVVGELLMEGPILAKEYLNSPEQTNNSFTQGLHWAPEKRLYKTGDLVKYDSSGHLHFVHRRDGQVKLRGQRIELGEIERQMALDPRVQHCLALVPGSGPCATRLTAVITLNGQFADTSSEMSTSGSTIELLSTPWLEHISCMRDYLLDRLPPYMNPELWIILTFMPRNSSGKLDRKTVTSYLENLTPEEFAEILPRMEEETWDRPGSEAELGMRQIWSEVLNIPEEEIGWNSSFYYLGGDSISAITISSMLRQVGLEVSTADILRYRTIERLARASTQSTQSKQTQTKPGDNSTTTTTTTDSFDLAPIQQLHFQASPEGDVLDQQTMVVKVTRIIVQDELLKGIRSLLQAHPMLRARFERRDDKWTQRVPSTSVGGVNDCRVRFHNRDEHNYVLECIAEARLSIHLTKGPLVAFDVFETARQTLMSVTIHHLVVDTVSWRILFRELEEFLLLGKPARQETDSFQSWFLAQQQFASALQPRDVLPPDVQVSATDLGFWGMDGKRNCFGDTVSRTIALDAGLTQSMSRASASSGVRTLDIMISSIIESFLQTFGRSPSVFTEGHGREPFSPHVDPSGTVGWFTTFSPVAAQHRDNILREVCGARSRTPLNGFSYFASRFLSEAGAEAFHGHDLPMEVTLNYLGDFQQFEKDDSLFKRCDDEFQKALSELRRQQRAESSRYALISLLAVTKDDRLSIQVEWNKQMDHQVQLADWVLRLEDVLKRTISNLSVSGLDSPPLSPSNVLPSSVGLQHTQLSKALDLAVSRFHLQPDDIEAVYPCSPIQDSLMMSQLKNSANLYSQHFLFRLSGQESIDPNRLLAAWKHVCAAHAILRTIFLENESGMFLQVVLRNVDSDVELLRMEDEPDLVALWAQQSRSAGPAPLDGKVLHKLRIYTAKDGSVYCLLDKNHLITDGMTSRLLIRDFLAVYDGCPKQGGHPYSSYIDYIQQQDAAKVSQYWSNYLEGAPTCHFPRLLQQSPPTNHRSEFTRVTAVITDKTSLKTTCRKFDLTPPAIFQAAWAVVLLAYLNSDDVVFGVLGHGRDVPIPGASEIIGPMATIVPLRVRFEGSGKTSEILRRVQDDSIEHISRQAVSLAQIAHAASRNGSAMFNTIFNFQRAITPEVGRIKSELLYSHDTSEYDIAVCVTEEQGQLQITLESPTHFMSAAQAERLLTSYATAVRSIASHPEAQAQELGLATDLDRIQLRAWNPARLETKHQCIHNVIAETTHRQPSRPAICSWDGDLSYSDLDSLSTKLAVRLQSLGAGPGEIVVLCFEKSLWAMVAMLAVAKSGAAFVHIDIQGAPKRTESVIMQTKSRLGLTSTAQHAKLASVVETVMIVHKTSVEELPSPESRDQPVASADPSSVLYVIFTSGTTGVPKGVVIQHKSFCSAVASNRSWLQIKAESRVLQFTNYCFDASLEEIFTVLVAGGCICIPSETDRLSDIPGFVARHQVNWAAFTPSYLRTLDPDELESLEFITVHAEPMSQDLVARWAGKIRMRPSYGPTECSVTSTVGAPFTVDTDATNIGWPVGCRGWVVHPENHDILMPIGAVGELLLDGPIVGKGYLDDEAKTAAAFIDPPAWAVEVESAFPEEGLPRKLYKTGDLVSYAEDGSLLIHRRKDHSQVKIRGQRVELGEIQFHLDNLSGIIQHSMVLVPQLGPLEGRLVAVVSLAATSSKSEIAVHGQSITIIRKEDLDSALSRKLGSIMDEMTSLLGRELPQYMIPETWLLVQSLPVQLSLKLDRQHVVKWVNGIDEKTLQAALDVHQNVDAGDEHCSPTEETVLRIWKRVLGIQQSHISLDQSFFRLGGDSIYAMQVMRLCKEAGLRVTTQDVLANPTVRQLASVASQVPDGQGSMPTPPQSPDMSSSLTSFAKLVLGTQDNVETVVPCSPFQQKMYHAFLNNPHKPYLFNNLVSLSNVDGKRASDADALQQAWQQTVHRHAILRSVFIFDASSNQLFHKILTEQKADISVHAVRSEADATAQSRLHLNDVRSRLFRDDTPPVSIRIFTADDGQTFVHFVMGHILIDHVSLAHVFSEFSAFYRGQTPEPALPPAGFHHYIQHVRQTRDLEESNRYWVEELRSVGPCMVRTASDVTVNSDPYSMGSVDFTVEMTTELRGFLREVGITFSSLLQFTWALLLHFETGHGSVCFGHLSSDRDIDFPHADEIVGPMLSMMVAQAELGDATGVLEALRVFQEDSIRSLRHKTFDLTEVERRLGRGTGLFNTLVNYRKVKYSDDGTAVDFRSVWKQDPHEQILVLAFNEGRSQLDATLTYYESLFSKAFVTRLSEEYGRILKLLVSGEHHTVGDLRVVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPW0</accession>
    <name>H1VPW0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-like transcription factor and archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_12315</name>
        <name evidence="6" type="ORF">CH63R_02264</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005264">
        <property type="protein sequence ID" value="CCF42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162055.1">
        <property type="nucleotide sequence ID" value="XM_018297239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPW0"/>
    <dbReference type="STRING" id="759273.H1VPW0"/>
    <dbReference type="GeneID" id="28861346"/>
    <dbReference type="KEGG" id="chig:CH63R_02264"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02264"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_6_1_1"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="225"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="341" mass="38153" checksum="0A82CC4B4FC4504F" modified="2012-03-21" version="1">MAEDTNTYAPKSPDLSSFYSAAPAPPTPPLHNLQHNQQHLNKLQTAAPPVYEYSSPSPRAYHPHQSSSTPVHIKQEQPPHYPPSVAIKSESVFSSHQPQTQTHHRHQHQQHQQHAHQPQYLSPRYQRSPPQQHQQHPSPQHPPQSAYGIQPAVKHQEQYQPPPLQSQGFLDLKTYGGPTQLYDIPYNPDSQHLPQTPGPATMPPRKNTQPAPSPPPIDPSPIRTKFPTARIKRIMQADEEVGKVAQQTPIAVGKALEMFMIAVVSRSAEIAREKNSKRVTAQMLKQVIETDGQYDFLADIAAKVGDEEKRGSRSKAESESEEEMEVETKKKGKGGRKKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRS8</accession>
    <name>H1VRS8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-1,3-endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_12790</name>
        <name evidence="5" type="ORF">CH63R_08980</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006412">
        <property type="protein sequence ID" value="CCF43835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155336.1">
        <property type="nucleotide sequence ID" value="XM_018305912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUC6"/>
    <dbReference type="GeneID" id="28870019"/>
    <dbReference type="KEGG" id="chig:CH63R_10938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10938"/>
    <dbReference type="eggNOG" id="ENOG502SURB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180920_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497740" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="100" mass="9984" checksum="D9814594E5C0E8D9" modified="2012-03-21" version="1">MVRVTLLATLAFAATAFAQITPNKAGSSNVGKGDGSQFITGGCVDDSDCSSACCADASGVGVCSAEAAQFQNGKNGCNFVDPNREATIAAAQAQAEKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVD4</accession>
    <name>H1VVD4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_03268</name>
        <name evidence="10" type="ORF">CH63R_13367</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006690">
        <property type="protein sequence ID" value="CCF44194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152758.1">
        <property type="nucleotide sequence ID" value="XM_018308341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVD4"/>
    <dbReference type="STRING" id="759273.H1VVD4"/>
    <dbReference type="GeneID" id="28872448"/>
    <dbReference type="KEGG" id="chig:CH63R_13367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13367"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029938_1_0_1"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="205"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF44194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="451" mass="49836" checksum="FE567F7F3C5228A7" modified="2012-03-21" version="1">MAFYQQTAPAQLPQNPYGIPSTTIEPTEGYLRLLRSMAHRRDVLVKNGFVVKPLSEADIDDKRRCSRCNMRCSNKRNKSKPNANDAKKGSSNKLPVGSGPASRPRFNLASAVLTHSDGEEEPEKPPKPVLKCQYHTGCAVRMYYTCCRAHISAPGCTWAPEHQTRSYDPGDLITRYQHHHTTARPLLGLFPSTSPSSPPSPTPRPAVAIDCEMGTAYDGESELIRVTLVDYFSSEILLDSLVYPQVAMQHYNTKWSGVSRQQMNDARAKGKCITGGLDAVRAAVWRWVGPDTVVVGHAVHNDLASLRWIHPLVVDSLLLATAARAEREKREQEEEEARNEAAAAAAACKGGVDEDLISFARLDIASREDREKTSAQDVAKEKIKGKRKPGGLSLKALTAEMFDRQIQKGRTGHDSLEDALAARDIVHWFVMQRSAEMQSQDQGVPVAPGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VW33</accession>
    <name>H1VW33_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00065</name>
        <name evidence="3" type="ORF">CH63R_02379</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006902">
        <property type="protein sequence ID" value="CCF44444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR13653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018162170.1">
        <property type="nucleotide sequence ID" value="XM_018297354.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VW33"/>
    <dbReference type="STRING" id="759273.H1VW33"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02379"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="428"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF44444.1"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="639" mass="73591" checksum="CA558E4ECB8809D8" modified="2012-03-21" version="1">MNPAGFIQLPPGPPRPLTKAAVGHVNPRPQPHQPAPRGPMPGLPPHQAVQRPMAPTMAPVAMPQPMPQPMPVPPPNDAIPLELRQKRLVEPSDLRSERMTEANAREALSEYVVYRLEKVNDPDEIDDEGYPAVPTWENVTRTEVRDLSKPVITRTIRHLDDEGKSVMQKKLKLTATQQRQIEKAQNDLETHNHDKRFCYTLQQIDTKMKKLSKDSTEYRQYIAGRESKKVTVSKTKKSKKNLLETTSLTVYFKREPRAGVNSTALLGEQSREAEHNRRLEDQRRQNMQAQQLMAEQHRHSMLMRQQQENLARSTMPAPMQPSQPHHQHNPPHPPQPKQFGAFKGTKVHVIENDPRRGGKPKVYPASSKGSRSSGSSVSTESSSDSELTLGSSVTGSSDSSRHGRRRHRSHSRGRNRSRNHSHGRRRYHDRPEHYGLPSRHHTKHNQHYILNGDTPRGGLMPTPLPPAPMPMPDSVDHLGDATSRSRRIADRAYGHELDDLNLFRLRRQSTLPPRVVHRHPGYRVVDSEEVIRHRHENDLNNLRRWKIRDEALYEDEEESAAVRREAAARIRRHLEPRFRRQSQERFVISREDLEETFEAMEARKYMNRQERGAWSPLENQFEPLGRPGRRETFAPARYN</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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    <name>H1VZS3_COLHI</name>
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        <submittedName>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Glomerellaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008013">
        <property type="protein sequence ID" value="CCF45735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156123.1">
        <property type="nucleotide sequence ID" value="XM_018304100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZS3"/>
    <dbReference type="STRING" id="759273.H1VZS3"/>
    <dbReference type="GeneID" id="28868207"/>
    <dbReference type="KEGG" id="chig:CH63R_09126"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09126"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF45735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="234" mass="24947" checksum="3B1BA119FC22D047" modified="2012-03-21" version="1">MAPVVLILGAGRNIGAGVAAHFSAAGYSVAVVTRSFPTPSPSPDPETGYLRIRADLSDVAQVRDTFAQARKHFGKAPRVVVYNAAALTPPPDAENLFSLPVEQVEADLRLMNSGAWVAAGEAVSGWTEDAEEGAKGRFIYTGNLLNAIPLPVPLLVSLGIGKNAAWSWVSVADAVYKEKKGWRFFYADERKADGSSIGNVPDAESNGKFYVELAEGAKDLPSTVTFVDGKYQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">HET domain-containing protein</fullName>
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        <name evidence="3" type="ORF">CH063_00632</name>
        <name evidence="4" type="ORF">CH63R_01413</name>
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            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009012">
        <property type="protein sequence ID" value="CCF46739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164750.1">
        <property type="nucleotide sequence ID" value="XM_018296388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2M6"/>
    <dbReference type="STRING" id="759273.H1W2M6"/>
    <dbReference type="GeneID" id="28860495"/>
    <dbReference type="KEGG" id="chig:CH63R_01413"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01413"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="235"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF46739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="556" mass="63410" checksum="5825CB0D398779C4" modified="2012-03-21" version="1">MWLINTETLVLEEFTDPSIVSYAILSHTWQKNEEISFQDMNNLEKFRHKAGHAKIEKLCDIALRRYGCKYAWLDTCCIDKTSSAELSEAINSMFRWYKEAYVCFVFLSDLAPEATRGHPPSDQGPAHHNISDLGRCKWFTRGWTLQELIAPTYVEFYDAGWNFRFTKDGWAARLSAITNIDVDILMLKKELSTVPVAVKMSWAADRETTRVEDRAYSLLGLFDINVSMLYGEGHRAFQRLQEEIARETDDMSLFAWDVDVPPDAAGQQRTAAQRYRGIFAKSPAEFRSCQGLRRVGKLSYNPPELSITNKGVRAAMHLSFDGDSECTMQLGTVAECCWRCRGSHVVKIGLVYTAGGWVRVLRDQCWQKQDQRRPGISRHVDICVRKQVSWEESKVLELFPPFSFRVLLDLGKDGGRIVSAEPERLWDPVHLAFVGEALAEDFVGVVDVVSRVPVEFRLRLTICMLKGKPADVELHGWPPEDWLASNGIAAPETSECDLEELLGVYRESARLEKRGHADRIRAVKRKEDWRYHDVGFEASLGEDLRVTVSRVVEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1W505</accession>
    <name>H1W505_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chloroperoxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_04203</name>
        <name evidence="11" type="ORF">CH63R_12405</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009878">
        <property type="protein sequence ID" value="CCF47569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151796.1">
        <property type="nucleotide sequence ID" value="XM_018307379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W505"/>
    <dbReference type="STRING" id="759273.H1W505"/>
    <dbReference type="GeneID" id="28871486"/>
    <dbReference type="KEGG" id="chig:CH63R_12405"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12405"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_0_3_1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497801" evidence="8">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF47569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR03278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="282" mass="30947" checksum="B23B96D14B51B6E6" modified="2012-03-21" version="1">MKQFIAIVALAVGLASADPLLAKAHMSNPHIRRGSLDEWAPAGPNDFRGPCPMMNTLANHGFLPHDGRNLTQENVVKGLREGLNFNESLGELMFKMAIPVNPEPNATFFTLDQLNVHNVLEHDASLSRTDAFFGSNHIFNQTIFDESRAYWTKDILDADQLANSKIARQINSKAFNPNYTFTATVENFSLGEVAAPIIAFGNMTAGTVNKTLVEYFFLNERLPAELGWVKKENAITQEDILGVVGLISKATSLITGGEEEAPHARAIRDLHSGFSLLAQRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQ98</accession>
    <name>A0A1B7XQ98_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf341 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150466.1">
        <property type="nucleotide sequence ID" value="XM_018309494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQ98"/>
    <dbReference type="GeneID" id="28873601"/>
    <dbReference type="KEGG" id="chig:CH63R_14520"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14520"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="202" mass="22271" checksum="5D6329C1FE9F7859" modified="2016-11-02" version="1">MLDIDDILATENELRQVIEDHGPFDGLLGYSQGGSMAAQIAIRLLIENPYATPQELPIKFLVLINSAVPPFIMPLDEQEVTDLPIEEAPKLQMLFDVFKANPADHLDKVRPAKLANGRQALVSKTHYMTFFDKAWDGHPLSMPSLHITGLGDAPEYGQQLFDIAEPGQAELIGHVFGHDFPRGLDMNKTIASSIMALADRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQB9</accession>
    <name>A0A1B7XQB9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150476.1">
        <property type="nucleotide sequence ID" value="XM_018309504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQB9"/>
    <dbReference type="GeneID" id="28873611"/>
    <dbReference type="KEGG" id="chig:CH63R_14530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14530"/>
    <dbReference type="OrthoDB" id="5352492at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR01958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="509" mass="56544" checksum="478700CA773FA8F1" modified="2016-11-02" version="1">MWLRESLQATAVEVSIKRDSKAASPRDIDAFVVQTPHLKLCTSLDVLKRHFGDSSLDNRSAISVRFEGVSQWVLDVFRHIPLEIRPPEPVTRSGMSNDHSLRRCGVWVHPQFEGRTILRLEGIAPAGNERVMGFTEFVQNNLHASGMPDIRVVGSVCSTMAGLTAEVAVRASVPDHSVVSQESRLSFAGSLSWNASNTRVEFAASISDSRGSLFLQPPETMTVKDVANWAVGRFSSSMRVEDRQDASMMEGSFMDVLGDIAKSIVPRQLSLTIGAGSALTPFQIDVELRLNLGAKDNIYPFREAFLEISLDTTNAVDAIFLPQLFDKEANVDDFLKGIPLTLRNASVKVSLGDWKKLVIRGRLQCSALGVESDVMPTVWLDELQLFYMRDFSTKSTEFELRGNINLKAPDYVFSIQRSAIVCVYIDYNEDSWTLSADAVDVQTANFYSLLPIDVSNQALMKLMSDVWVPEISVIVKFANGKAKATNIDGIFAIRPLQMFLNYYYSSEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQD6</accession>
    <name>A0A1B7XQD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150479.1">
        <property type="nucleotide sequence ID" value="XM_018309507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQD6"/>
    <dbReference type="GeneID" id="28873614"/>
    <dbReference type="KEGG" id="chig:CH63R_14533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14533"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR01961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="113" mass="12344" checksum="203453A7B7AD5EB4" modified="2016-11-02" version="1">MKKEPASKSVESEETVLRGAVDCIRAIAPHLQHQADYRAEAEDQQEESEQNLAELEAQCWGVGMDEGGVGSSGRRRGHGYDRGQQGAVHQEKEVSRQRLGGARVKEGETEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRF4</accession>
    <name>A0A1B7XRF4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_13579</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150871.1">
        <property type="nucleotide sequence ID" value="XM_018308553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRF4"/>
    <dbReference type="GeneID" id="28872660"/>
    <dbReference type="KEGG" id="chig:CH63R_13579"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13579"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR02353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="429" mass="47999" checksum="E82CE130338B96AB" modified="2016-11-02" version="1">MADHAPPVYVQATRLVLDIASGRHALSKAIPPLLLALDAVLCGLIIWKIPYTEIDWVAYMEQVSQFVSGERDYTKIKGGTGPLVYPAAHVYTYTGLYYLTDEGKNIFLAQQLFAVLYLATLAVVMACYWQAKVPPYIFPLLILSKRLHSVFVLRCFNDCFATLFLWLAIFFFQKRLWTPGAVLYSWGLGIKMSLLLALPAVGVVLFLGRGFGGALRAAWLMAQVQIVIGVPFFSHNAAGYLGRAFELSRQFFFKWTVNWRFVGEETFLGKPFSIALLALHLSVLLLFAVTRWLNPAQRPLSSLVPAMLRGKSPFSALEEAQVAGRVTPRYVLTTILSANVMGLLFARSLHYQFYAYLAWSTPYLLWRSGLPVYVVYILWAAQEWAWNVYPSTDLSSEFVVGVMAVTVAATWFGTADEGVPAEKPASKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRS5</accession>
    <name>A0A1B7XRS5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor Tos4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150990.1">
        <property type="nucleotide sequence ID" value="XM_018308672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRS5"/>
    <dbReference type="GeneID" id="28872779"/>
    <dbReference type="KEGG" id="chig:CH63R_13698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13698"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="57066" checksum="83CA4833ECC7BF31" modified="2016-11-02" version="1">MMDSSPQSKSLEPTLPLAGTKRSAPSLLPPFEPLSSSPGFPRPSKRQARPGSVGGKNAYLKYPTPIPTSSTGILSSSPPRVHQRPGGLPRALSSASERTPLGALASIELNDSGETLLMGRSSNSSHYQLSANRLVSRIHVKARYVPAASALEPNKIEIICNGWNGLKLHCQGRTWELLKGDSFTSETEGSEIMLDVQDARVMIQWPKRDRHDRLASPDESAWGDSPPRSAARAAADLLQSSPLRHASRIESPESPTPVHLSSSQRLQALLPTDDGEVHIYEDLIADEPELPKLADSGTIIGQSFATEATNSFSSELSEPEDENDPDEENDPVVHSFGPFGADISNRLASITTASPKLPSFKRPGLSTIHDEANASNASSPISAPPKSPEDEEEDYEPKEAEPPYENPAVRNHVVNQLAFSRLSSNPLSTIMNNLPSEEKRGLAKDQLRSLIEATACIGIIRRQGKDAAGKPLESEYYYVPEADDDDQRRLAVTDGLRKPSLRACRKQHKLSSHAPGSYDLALLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT38</accession>
    <name>A0A1B7XT38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA (Guanine(46)-N(7))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151450.1">
        <property type="nucleotide sequence ID" value="XM_018309132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT38"/>
    <dbReference type="GeneID" id="28873239"/>
    <dbReference type="KEGG" id="chig:CH63R_14158"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14158"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="420"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="880"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="837"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135428" checksum="3AD9B28C17D70DA1" modified="2016-11-02" version="1">MALQGRDLILAAVTCFIAWGYAVSWVPTLRWMGYALVGGVVLTIAALFALTLLTSRGFRRGLRHRSPRPNGPAFLAPKVWAREIASLQARQAYSKVPIDPDSRRISKALDDLIELIIRDFVSSWYSNISKNPVFSNQVDKAVRDALIGIRERLLELDLVDIVTTRVVPMLTAHFRDFYEAERAVRGKKLNRSVTESEELDLAIASKYKDGKLHPAASLSFPDTKLVQQDYLRKMVSAILPNVLPPSVLASRAVSTIIREIVACAVLFPVMQILAEPDTWNQVMENYGRSMLQDRSTVRKLRAALDQHASPTPRSSKAAIIPRLSPTDNERKFEKFIRAIRKVNNLSDARRLRSEVASQLKRDSLEENQDQVYLRRLEMGKRLLDQRVQLLAAGGSRQASATLPARPAGVPQVASKLENASLVDLLRDASGLSYFMEFMDRHRMMPLVQFWLVVDGFRNPLEDEGQDDEHLPSNLPMWTDSDRLDLAQIDHAYLAKAELRVSQASRDEVRAFLDAGKAATPEQYYKARRAILRAQAAVLERMQAQFFQAFKKSDLFYKCLAAQEASANIASSPTAEPSASSQAHPPMYRNSQSYQSKPGPVARLAPRLSRPLSRRAGSASDLASLIVNGSGGSEPVPRQRHSLDEETPAPLFDDDDFDQDGMMDSVQSLDQETGKLVPDTNVVQAMEEALNNIMEDNRPQTAEEFRASLFGPEDAVDRSSLFSGDNDSHRGSLEVSRPAAQSSKEAEKPSLASLGLVSAASRIGVFVDDDLFGDEDKYLSDERDDGGEGDNGDVEDEVHEAAPGDLGLAEAITALSNDIDRLIAQDAIVESLTKKAELTNNTAELRILRKSKASLQREIRRKELQRQQYVVQESDNSLYGRSSIKIKAIQVGREDDGREFALYVVEVQRDAGEKMPAATWMITRRYSEFHELHQKLRSRYPSVRNLDFPRRRMVMKFQSEFLRKRRTALEQYLRELLMLPEVCRSRDLRAFLSQSAIAQGTDIVDREDKKDMITRLYDSVTDGVEDILGNIPVLDQLSLAGQNLIAAATNQLNAVPLPVNEDGVSAAEAEAELNAFENKELESFIKPICDIFLEVFELNRGNNWLRGRAVVVVLQQLLGGTIERKVRDNVKVLVQEDAILKYIALLKASMWPGGEMDKNKQPRTASEKKKTRTEASLMLATLVPDLAGSVVGRVNAQAASRRVFATFNNSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XT86</accession>
    <name>A0A1B7XT86_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nipped-B-like protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151499.1">
        <property type="nucleotide sequence ID" value="XM_018309181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XT86"/>
    <dbReference type="GeneID" id="28873288"/>
    <dbReference type="KEGG" id="chig:CH63R_14207"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14207"/>
    <dbReference type="OrthoDB" id="4851807at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601020" description="Nipped-B-like protein B" evidence="2">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38267" checksum="3968CF40791E36F8" modified="2016-11-02" version="1">MRFSKSLIVMVAASMGANGAPSGMDTLARQATPALPAAAPAAPAVPAAPPSVPKADDDKKGDGDNKGDKKGDKKDDDDKKGDKKGDDDKKGDKKDDDDKKGDKKGDDDKKGDKKGDDDKKGDKKGDDDKKGDGDKKGDGDRNGGGRDGNQNCAEEDRGRDRDGKRCCVTRGRDGDRNGGGRDGDLKVIRVDRDGDREGERGGDRDGDRDNGGRDGNRNGDSECTREGGEGGRRGGNNDDDDNDNDNDRRPPPPNPFLPPYPPPPGFPIAPAFPVYPPLAPGGPRNPDGPRNPDGPRRPDGPGGSDRPDRPDGPDRPNGPDRPDRPDRPDRPDRPDRPDRPDRPDGPDGPRRPDEDKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTB5</accession>
    <name>A0A1B7XTB5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151514.1">
        <property type="nucleotide sequence ID" value="XM_018309196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTB5"/>
    <dbReference type="GeneID" id="28873303"/>
    <dbReference type="KEGG" id="chig:CH63R_14222"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14222"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601044" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20771" checksum="1002D8E837CDB788" modified="2016-11-02" version="1">MHSQIALVILGSVSVLAAPASVATATEAIFDVDIAAAAAPPPVDIDISQDYPVGAWNFLGNASWSVANREDNLVWVHESRYSTVPVTVEPELAARGIEERTISNQWKIGFGKSSCPSQTRTINRDVCITQPNEPIYAASQAIVYSNTAGYSPKVNYYSGSGCGSYMFSVIGTGTKCANLGNLNVWSYIAFNQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUG3</accession>
    <name>A0A1B7XUG3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151923.1">
        <property type="nucleotide sequence ID" value="XM_018307506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUG3"/>
    <dbReference type="GeneID" id="28871613"/>
    <dbReference type="KEGG" id="chig:CH63R_12532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12532"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029038105" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="318" mass="34029" checksum="87D22A05B9DFBF60" modified="2016-11-02" version="1">MRSPLTWAAAALLPALGSAASLQQITTDFGPNPTNVSFYLYVPDSPAPAAPLLVFPHWCHGTAQDAFNWKPWRPLADALGFVTIYPSSPWAADNCWDVSSPQTLAHDAGGDSLGIVSMVRWTLDNHDVDRDRVFVAGVSSGAMMTNVLLGAYPDVFAAGSAFAGVPFGCYAADGFAVWSDDCASGRITRTGEEWAAVVEAAYPGYAGPRPKLQVLHGDVDNVLNVTNFYEEIKMWTTVLGVGATPTAVVEDDPVAGWTKSVYGRRGLFEAFLAHGVDHNIPDMPDEVVRFFELDCVGEGCFSRKSLPVPGACVKRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUY3</accession>
    <name>A0A1B7XUY3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152089.1">
        <property type="nucleotide sequence ID" value="XM_018307672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUY3"/>
    <dbReference type="GeneID" id="28871779"/>
    <dbReference type="KEGG" id="chig:CH63R_12698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12698"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="25139" checksum="47E1B8C0857BA711" modified="2016-11-02" version="1">MGLTVLPALIPDIPKVYDAYFGAFKGSVILDILFPTGIDEAFREGHTKHTVDYWHKTNTQYTIKCVDAETGEIVGMALWDVFLKERTPEEYQSPGAVWLQGEQRARADELITPLNEAKEKIWGGRRYVLKPEHQRRGAGALLTKWGLDMAELAGLPVYLESSEEAFALYKRLGFEVLKEKIVHRAGLVGAEKDVEVPLMVKMPSAAKGLSFEEWRARGYPPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW00</accession>
    <name>A0A1B7XW00_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152480.1">
        <property type="nucleotide sequence ID" value="XM_018308063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW00"/>
    <dbReference type="GeneID" id="28872170"/>
    <dbReference type="KEGG" id="chig:CH63R_13089"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13089"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="238" mass="26258" checksum="98B34D7C6DC91F9B" modified="2016-11-02" version="1">MPLVSGQWRPPAFGGIFLALDCVEPTAACLSLGSIVRYHRRQTCKGSEFALYTSRSSKACMTPPTVLSPRQAYRTLHHTISPPIRLPGPFDSTLGGHVPRTIASHAFFLVMGPSSLHEVADRLADRKQEQTFILTAQYVSGRFTLQRTCAKTGTNSFIPLSFHVKYVSHLQHAEKVARSSIGSEKQDVKRQDRLPRQQIRRNMTGILSQSDRGSPSCDQDTASRNSSTGDFSRPDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWI0</accession>
    <name>A0A1B7XWI0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf6 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152651.1">
        <property type="nucleotide sequence ID" value="XM_018308234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWI0"/>
    <dbReference type="GeneID" id="28872341"/>
    <dbReference type="KEGG" id="chig:CH63R_13260"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13260"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="396" mass="43375" checksum="53851800A5E56FC3" modified="2016-11-02" version="1">MAGFPSYTIRTFAFHTHLRVMDKGLNRSFFQRHKPSLLVLISQLSAAALNGFAKFFETADNPVHPFQVLFVRFLITGVASTFYLWYAKVPNFPWGLPELRPLLALRAAAGVFGAFGFYFSIMYLKLSEATALNFLGPLTAMILTRYLDFGTFEVIDRIGALVALLGVILVVQPDTLFGSQSTLKSARQSTADDGAKGRMMGFGFGVMSVIGGAIALTAIRSIGPREHPIFSVMYFAWTIVLVTTVAFFLMESVHLTTSVLSWLKLVPLGGFGFAMVSGRCLQRVAHPNSGRLQECLLTAGIANDASSAATIMIYSQVAWALLLDWLVWHSPVNILALVGIGSVLTSLVVVSSAKEWRWLRKGRYNILSQTSPDEAEQVDGDVDEEVVEMQPNSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXH5</accession>
    <name>A0A1B7XXH5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152962.1">
        <property type="nucleotide sequence ID" value="XM_018306121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXH5"/>
    <dbReference type="GeneID" id="28870228"/>
    <dbReference type="KEGG" id="chig:CH63R_11147"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11147"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="530" mass="58469" checksum="2A4539747A29A09F" modified="2016-11-02" version="1">MAPNRILKHFNSTLAAAFTVIAISTFNYGFDNAGYSTTQAMDAFQRQFGDQNPTTGKWKLPTGWLALFNSLNYIGFAAGVIIGSLVSARWGRRWCMFAMSAWAVIPATIAVTSNTRKQIMAARILNYIYVGMELAVVPVYQSEIVPSEIRGFAVGSYQFSLMFGTLIVNSVCRGTSTLEGNASWRIPMGLFYVIPVVVMGLIFFIPEKSKSPRWLLTQDRVEEAQVSLKKLRSGTISDAEIDEQFASLQYALKQEVEQGNYMELFKGINLKRTAIVVMMNFLQQATGQAFASTYGAIFIKDIGTVNPFTMTIINAIVNLCMVFVGLYLNDRVGRRPLLLIGAVWQFAAIVTMGSLGTVVDPSFAVKTSIVAMLTVFAAGYVFAWVFDDDSLKSGNIPLTNGQAPLNYVVTTEIPALRLRDASQRTASMVNVLANFLVNFSIPYLLYTPGAGLGSKVGFIFAGILVFALVFTWFCIPECKGKSLEQIDRMFNEGIPLRNFGKYKPEDVFQDSTEDGEKGGVIVMARHEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY68</accession>
    <name>A0A1B7XY68_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153202.1">
        <property type="nucleotide sequence ID" value="XM_018306361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY68"/>
    <dbReference type="GeneID" id="28870468"/>
    <dbReference type="KEGG" id="chig:CH63R_11387"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11387"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="246"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="46203" checksum="4EE9C45E8A0995CA" modified="2016-11-02" version="1">MACSRPGDPPTRQSNPGAGAADGLTSDGGDPDPISIMPSAVSPEAPPLPKWQRPENTKYELPWADIAVIDISKFDQPGGKKQLAEDLRQAVHETGFFGLINTGFTPEEVQRQYDIGQGFFRLPVEDKARPGNTCDFAKGNYFGYRSAHDKKMQGTDVLNNVESVNIAKFIPKYQDEPFHPFFEPFRAEIEDFSRRSLELASKVFTLFSIILELPEDYFSSRHAYGSPSEDHLRYMRYHPRALADDLKVANTWSRAHTDFGSLTLLWSQDVAGLQIKTAETGEWRHVPPVDDDGTGVVCNVGDTLEFWSAGYLKSTTHRVVRPPEDQAHLLRQGLFYFVRPGDDVDIKPAPSPLLRRLGLVREDAAGDEAPPVRGLQYVRERVRDYHDHNDYADKKGQKFRVGNLEIEDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYD1</accession>
    <name>A0A1B7XYD1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fungal specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153278.1">
        <property type="nucleotide sequence ID" value="XM_018306437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYD1"/>
    <dbReference type="GeneID" id="28870544"/>
    <dbReference type="KEGG" id="chig:CH63R_11463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11463"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="434" mass="49444" checksum="0706F04B951A0662" modified="2016-11-02" version="1">MKGRNWSPVGARRRGLKSFAARLTLRFLAVASIVVMYHLIELHLRYREAMRAKYLPTRFDSLPDYDEATLASTGWDADSYTENTERSTLLDNRRHWKKLGKGREGETFTFNNTVIKVYNEETTPFRNCMQDTRASPRRWPTEIPASLIMGGHRDGSNPSHDDPYRELFVPVKDYFLTTTDPSQPPKWHLVTPFLKSGTLKKLAKTLHAASDGSPTYRELDQMFRPSFESLLSALDNLHMAHNLCHDDVKLDNIFVASERDPRRWKLGDLGNAREPDHPYHLTPLWTADTPQLRDCRANDALRLTKAYLQFLRRSGRNPDEFDDALMRGVDTLSRLYWAVARASPPLSAAQIWQLSGVYPPQLEGAEQSPWMTMQPAGVKESRGWAPAAEAVFGWRWSLRNAVKSELRVGAKENMGRFFGLTRILGIPVAACQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ11</accession>
    <name>A0A1B7XZ11_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CH63R_11695</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153510.1">
        <property type="nucleotide sequence ID" value="XM_018306669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ11"/>
    <dbReference type="GeneID" id="28870776"/>
    <dbReference type="KEGG" id="chig:CH63R_11695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11695"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="542"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="731"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OBR04992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="748" mass="83629" checksum="2189C7C8EA497EBD" modified="2016-11-02" version="1">MTAKPLGPLSGGSNENTRTVLRVTILSLIAAAAVASRLFSVIRFESIIHEFDPWFNFRATKYLVANGFYKFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGAIYHALRALTVPVDIRNICVLLAPAFSGLTAYAAYLLTNEMTTSPSAGLLAAIFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKALKLGSMLWGALCALFYGYMVASWGGYAFITNMLPLHALTLILMGRYSARLYVSYTTWYALGTLASMQIPFVGFLPVKTSEHMPALGVFGFLQLVAFIDYVRGAIPSRQFQTFVYTFLAATFGVALAGLVALTSFGYIAPWGGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNMLVWLFPAGVYLCFQNLRDEHVFIVVYALFGTYFAGVMVRLMLTLTPVVCVAAAIAASQIIDTYLVAKSPNPEDYKPEDAIEGTPKKTGKGGLKSTSKPVIGIYTFLSKAVVVGGMSVFLLLFVLHCTWVTSNAYSSPSVVLASRLPDGSQHIIDDYREAYQWLRQNTKEDAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPIMRQHEVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPEEVQERKFFTPRGEYRVDDQATETMKNSLMYKMSYYNYNSLFPAGQAQDRVRGVRLPDVGPTLDTVEEAFTSENWIIRIYKVKDLDNIGREHTAASAFERGQKKKKPTKKRGPRILRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZX4</accession>
    <name>A0A1B7XZX4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_12016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153831.1">
        <property type="nucleotide sequence ID" value="XM_018306990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZX4"/>
    <dbReference type="GeneID" id="28871097"/>
    <dbReference type="KEGG" id="chig:CH63R_12016"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12016"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="261"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="624"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="879" mass="96433" checksum="A1B458F9FB974974" modified="2016-11-02" version="1">MLLQSEKIPSKYAPQEAKGAASTASIELQSSDGQTEPFTFTFEVVRPTVFRTTVTSKSRPIPPFPSAHKPVTDSAPTDVEVKTSENTQSFTTSAAKAVVEWSNTPIVSLYAGHDDSGKPIHADLPFRSYAADGPGIAHYSVYKKGTLHVGLGEKAAPMDLSGRGFLISASDTFGYDAYRTDPLYKHIPLLINVTPEGAVGIFSTAHSRSTWSIGSELDGMWGAYKVHRQSHGGLEEYLIVGRTVADVVRSYAELVGFPLRVPRYMMGYIGGGMKYSAMDAPRAHDAIMGWVKNCEKHDIPFSAFQMSSGYTVAEKEPKTRNVFTWNYHRFPDPRAFTREAHAHGVRLLANVKPYVLATHPEYKKLSAAGAFFKDPNTGETAVTRLWSAGGGESGEGSHLDFTSNAGYQWWYDGVVGLKKVGIDVMWNDNNEYTVPDDDWQCALEKTDLVPIPEGLSRKDVGIWGRAIHTELMGKASHDATVEGKPEERPFVLTRSATAGTMKYCGASWSGDNVTAWESMRGGNSLALNASFSLLHCYGHDIGGFEGPQPTPEHLVRWIQLGVHSPRFAINCFKTSEEDNLIGGVIEPWMYPTATPIIRATIKRRYELVPYTYSQNLRAHHTAVPPQRWTGWGYEADPEVWTKEIKNGDTQYWFGDALVIGGVYEPGADTARVYLPKKGDGSDFGFLNTNAPYEHLEAGRWHTVLSPWYTSIPVLARVGAAVPVGRPLDTTSRAETDPEFPNQAKDDWRGVEIFPPPALRGSAAAAAAVGGSDAESGANDVKGVVFKDSWYEDDGISREVAAEYKFTIRYEIVDGRISVEVKGAVTEGSREGWSPLWLEKGVDVVLPVGEERSVITQGGEAVEKTLDAKGRRVWNISVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y038</accession>
    <name>A0A1B7Y038_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alkaline elastase YaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_12088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153903.1">
        <property type="nucleotide sequence ID" value="XM_018307062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y038"/>
    <dbReference type="GeneID" id="28871169"/>
    <dbReference type="KEGG" id="chig:CH63R_12088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12088"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601214" evidence="9">
        <location>
            <begin position="25"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="173"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="612"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1247" mass="132180" checksum="07770CC9D8171AF4" modified="2016-11-02" version="1">MPRLSKILQSALVAVTAATSTVTAVTTEGGFASGRNRLAPPASDAASGRYIVELEKSTGPNARQEDSSAADSLVGQISSLGYEATVKEDFTAISGRFRGVSVEIANSNNVTSNNSGNSSGVVDEIKSIPGVADAWPVQPIALDVSFEETTDSQRWNPHIATRVSELHDRGLTGAGQRVCVVDSGVDVDHPALLGKVAGGRNLVDGDGSSSSSAATLTDCAGHGTFVSSVIAAAHKDFAGVAPDAEIYMYKVFGCSDATSNDLVLKGMLAADSDDCDIISVSIGSNTGYADSVLSRVASEIAQDRLIVIAAGNSGEMGPYFASSPAAGRGVVSVGSVEASQTMGWPATLVSSGGHSLNISYVTYDGAKFNQTVHVPIVLDAGDSCNIAGSGSETTAVLAKRGVCDSFQSFRSIANAGFGYGILFDSYNQGAYYFDDVAASSDTLQLMAVTTASVGEWASAQVAKNYTLHLKIESDAQPAAFAAEVPSAGQVSSYTSWGPTYENGFSPIVSAPGGIVYGAFPDGRFAISSGTSFATPYISGVAALWFAHAKKDRAEFVRRLTSTALALPAFDITDGKVVGGGLAASLAQQGAGLVDAAKLFDYTTVLLSEPTLSLNDTDNRVSTHTIRIQNTGSEEITYNISHVAASTISSRNSIWYPNTYYPPLLSAAGSLSEAKTVTVAAGATSDIEVTLSAPDVTAESGALWSGKILLAGSNDELLTVPYIGIEASTYNWTPLHHSPESYRYDQTDGSLYPIDYQGLAYRPAEFDSPEVYFAFRYGTYEFSVDLVGVDWKTEQFSYPPQHSSGPRAWYGSVRFQGYEGGGYMDFPMREVVRFNLGAYTTFRSFANGTDIPSGRYRIFTRALRIFGDAANPADWQLFLSDPFSIQLGDDPIPGQNTTWTSSVPASTSAATTTMTTAAAPTTTSVATTTAPISVPGSTTTLSATATPTGLADAFTSLKLQRLQEDAPFIIDPAAWMELHVQISLPSPVPADSVISFAVPPEITDIAQDVQLSASGAQAGHASFDPETRLYTIELAEWTTWHKNMVGNFFVMCRFTPEFAASMRQGTYVVQFPTVGRVHEASTYYTAVDRSAVYERLSIAPFDGTSLYTAEVEVPSSLGPWDFVRLTTSHAANSDGFVCANSSVVVGTALDAENRITASTDVTASATEVCNVKNFRAVYNETLAGDEVLRFTVSSIQGDRDMWTLSVAYLLDVQLSNGTMVLYDQRTLAFEKNPRLRTWGFNAFEGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0I1</accession>
    <name>A0A1B7Y0I1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-ketoacyl synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_12222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154037.1">
        <property type="nucleotide sequence ID" value="XM_018307196.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871303"/>
    <dbReference type="KEGG" id="chig:CH63R_12222"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12222"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="392"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1296"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1661"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1451"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1612"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1740"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1762"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2641" mass="288779" checksum="5E28E432CBFCF192" modified="2016-11-02" version="1">MSSFQQLVENSQVPSLLLFGPLALSFDQGALDRLCEVVSGNAEYSWILDTLASLPEHWESITASIPSLKQADPRLKKQLQDMRDTFQASKSWPDTGYPLPNTLLVPLAVAYQMTQYAAFINHTAGWTRLASADTETLGLCTGLLSAFAVSSAGGNKELFAKYGAVAMRLGLLVGMVVDEQDSLEPARSISVAWNSADGGEEARRILALDEFQGTYISVYFDETRATVTSSPTKLRALQQRLRESSLISSELALVGPFHAKRNLGCLDALLAFADKHPEFHFADTRKLAFPTRSNRDGSILGQNILHHEALESILVHPPQWWKTFSAAKDARLRVDTGSSNNNNNNNNNNYVVSFGPERCVPPSLMRPLRQHVVHLADHDRALFKALPRHIADSDIAVVGMACKVAGSDGLEEFWDLLCNGEPQHQELKDQRFSFQTPFRPADAKRKWFANLVDGADHFDHKFFKRSPRESATMDPQQRWMLQIAYQAVEQSGYFNAVSPERSVGCYIGLRGNDYYDNVACHPPNAFTATGNLQAFVAGKISHQFDWTGPAMTIDTACSSSLVAIHQACRAIIAGDCNAALAGGAHIMTSPLWFQNLAGASFLSTTGQCKPFDAAADGYCRGDGVGALFLKRHSQAIADGDQVLGVIPATAVQQNLNTTPIFVPNAPSLSDLFSSVTTRAAIAPSQISVVEAHGTGTAVGDPAEYNGIRKVLGGPGRDSPLVLGSVKSLVGHTECASGVVSAVKILLMLQKGMIPPQVNLKTINPALGASPRDNIRFATSLEPWNADFRAALINNYGASGSNASMIISQPTGKRALDSPAVTGRYPFWLTGADDAALIRYAGALDTFLSRQDGQEHASLSNVSFNVARQSNRQLQRALLFTAKSVGDLRQRLTAFAARESSAVVPIDRPAAKPVVLCFGGQTSTFIGLDKDVYDRAAVLRKHLDEVDARAKAIGVESVFPAIFERTPITDTVVLHTTLFAFQYASAKAWIESGVNPVAVVGHSFGELTALCISGALSLDDTLKMIVARARLIRDSWGAEKGAMMAIEADLSEVEMLLHDSAQSCPAVTPATIACYNGPRSFTLAGSVAAIDAFADTISKRGSSAFRTKRLNVSNAYHCSLVDPLTDRLEENARDLNFREPVIPLESTSRLSTMTKTQSSYFSEHMRSPVFFHQAVERLHKQYPSSIFLEAGSNSTVTSMAGRALGNPTDCHFQGINITCCDDGWDKLTDATVNLWKAGLTANYWGHHAAHTSQHTPLLLPPYQFEKSSHWLELKPVAPAVEVVVRETAPEVVPRSLINFTGYQKEGDNKPLARFQINTALAEYEKTLSGHVIAQEAPICPATMQTGFVLNALSSLKPELSKLVPQTHGVKFLSPICRDPGRSLWIDAVETKAMTWEWSIYSTARNGNGQKTMHTSGQFEYSSVDNNSLLAEISRYERLFSYQRCVELLNSNSVDNVLEAQVIYMLFSNVVEYGEEFKGVKKLVGKNDQSAAHIVRLNTQNESWYDAHLADTFCQLGGIWANCMANDRLSGEVFIANGIEQWVRSPRVLKQPYPSAFHVYATNARTSDRATLTDVFIFDAADGCLVEAILGIGYSKCPKASLQKLLARLTAGESGDASPASVERSAPVPLPGTTTEPPAQHQEAVSKQPKPIQVEKPKQAPKIDVMPRVKAILADLSGLEMEEIKDDSQLADLGIDSLVGMEMAHEIEAAYDITLPENELIDILDLPGLIACVQKALGGGSAALGTPRSPADSTDDDWQDGGLSASDTDVSTPPSSPDIMEADVKRGGKQVMDYAKTSLLAVDKVMDAFSDTKNLTDGRIAEQGQTAYVEGALPRQTELTIALTLEAFEHVSQSPLQKLRSGETLDFVPHKKEQRPLVRHLYRMLETETQTIVVNSNDTITRTAVPFPKIRSSEAVYQELMTRFPDQSTANKLTKYAGTHLAEVLSGKTDGVKLIFGSAEGRELVSGFYADWPLNQALYKLMDDFFNALIPRLDITPGSGPLKILEMGAGTGGTTKRLLPLLARLGVPIEYTFTDLAPSLVAAARKKWGKEYPFMKFRTHDIEKVPADDLIGTQHIVLSSNAVHATHSLVVSTGNIRKMLRPDGLLLMLEMTRTPYWVDLVFGLFEGWWLFEDGRSHALTHEDRWRKDLQTAGYGHVDWTQGATAESEIEKLVIALADPASVSGYETHARTSVSLPRESTPADCAARQAVVDRFVAELVEDFDAATRGDSAYLGISAPPTPGTTVLITGATGSLGSHLVEVCALMPSVARVVCLNRRSKEERDPANRQRQAMDEKGIPLSGQAAAKMVVLEADLSKPQLGLTETDYAQLVRSTTHIVHNAWPMCFKWSVKRFEPNMQGLLNLLILSHHAADHRRRHGNPGFQMTFQFISSIAVVGHYPYRTGKAAVPEERMCFSSVLPTGYGDAKYVCERVLDETLHRDTDRYHAMSVRLGQIAGSSKTGFWNMTEHVAFMLKSSQTLKALPDFGEKGVMSWTPVDVVAQTCADLLFQPSSGHAKREQSCHPIYHIDNPIRQSWSDAIRVLAKTITPGASLQVLPFKEWTRLVREYTPPASVGKEKPGPEMKNPAKLLIDFLEDDFERMSCGGVLLGTAHAREHSRTLAGFGAVSEEYLELVIGSWRQRGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y179</accession>
    <name>A0A1B7Y179_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nadh-ubiquinone oxidoreductase 105 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_09875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154273.1">
        <property type="nucleotide sequence ID" value="XM_018304849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y179"/>
    <dbReference type="GeneID" id="28868956"/>
    <dbReference type="KEGG" id="chig:CH63R_09875"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09875"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="11">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR05755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="152" mass="16662" checksum="75D6C7873FC928EC" modified="2016-11-02" version="1">MEPQVCTTRISNFFMQTGPPATCGISSTSIPRHLSRASPIKSTPIDLTSLPPRLSARPPSRASATPKKTMSSKYAFTKALKEVRFLFCQTGEHSAATRSFITRAYPTMKKNNPQTPILLREAAGTLPKVYARYGLSDKQIEDTVTTLVKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3E9</accession>
    <name>A0A1B7Y3E9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155046.1">
        <property type="nucleotide sequence ID" value="XM_018305622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3E9"/>
    <dbReference type="GeneID" id="28869729"/>
    <dbReference type="KEGG" id="chig:CH63R_10648"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10648"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="439" mass="48627" checksum="1064812FE16272E1" modified="2016-11-02" version="1">MGSIAFDGGSTADVPTIPAMEAAFAAAVKSSKIPGAVVMAKNTTGTIDYARCFGARTVRRDETRRLPPMEEDTPMRFASATKLLTSIMALQCVDRGLIGLDEDVEKIIPDLTSMKVLAGFDDAGNAIMRDREGIITLRHLLTHTSGLSYVLINPLLQQYMSKGYLPAADKFGIQSRLAPPPVNDPGVEWMYGSNLDWAGRLVERATGMDLESYMQENLCDPLDIIDMTFKLQQRPDLLARRADQTQRSREDGKLVYDDTVYFRQDGEECFGGQGIFTSPESYMKVLFSLLKNDGVLLKPDTVKLMFQPALDERLEKQMNAHMDSATHINYGGPMPMTGLRRNFGLGGIIPMEDLDGDKWRRKGSMTLGGGPNIIWVRFFSSASGIARHADTFFSNHLQQIDPAAGLCTLVTYQLEPWNDPICRGLTQTFEKAIYASLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3G0</accession>
    <name>A0A1B7Y3G0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methanesulfonate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_10643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155041.1">
        <property type="nucleotide sequence ID" value="XM_018305617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3G0"/>
    <dbReference type="GeneID" id="28869724"/>
    <dbReference type="KEGG" id="chig:CH63R_10643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10643"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="47"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="393" mass="43202" checksum="37B2899DB03A7BC8" modified="2016-11-02" version="1">MSASSVREGGPALKGPFDFEDSPLSRAARQPLLLGLFLNLQDINFSTQPTTNSWTFDYNVELVRRAEELGFELAFSRTQWLPKGGYDGEASLDAFVALGAMAAVTKSILLISTMHVLYGPLHPLHIAKYGATLDHIAKGRWGINVVTGHRAVEHEMFGRQRIEHDKRYQMAGELFDVVNSLWGETENISYKGKVSPWQLENAWITPKPQFGRPILVNATGSPAGIDFAAQYSDLIFITSPGTAHIDSALETLPDHIASIRAAVRAKGRTVKIIINPIIVSKDTSEEAWSYAESIAEGTRIQAGTKKFGTANGAYDSDAHAWRGRKDAKEKKGLNLGGNIEIIGSPEEVVQQLDALHKIGIDGVQINFYDFAPDLEYFGQKILPLLKESGLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y438</accession>
    <name>A0A1B7Y438_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155286.1">
        <property type="nucleotide sequence ID" value="XM_018305862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y438"/>
    <dbReference type="GeneID" id="28869969"/>
    <dbReference type="KEGG" id="chig:CH63R_10888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10888"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="99" mass="10827" checksum="BE534B883958B742" modified="2016-11-02" version="1">MSPQQSRVSLRGKNSQSLPPSSHSAKVQRPQPRTKTANIRIVCCDSFRPRKSAISRYLLTVLAICPALSLGLVEVSQANISHCALEPQLLGTCADQTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4Z3</accession>
    <name>A0A1B7Y4Z3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trichothecene 3-o-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155605.1">
        <property type="nucleotide sequence ID" value="XM_018303582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4Z3"/>
    <dbReference type="GeneID" id="28867689"/>
    <dbReference type="KEGG" id="chig:CH63R_08608"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08608"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="53907" checksum="B811A3A46D3FEF93" modified="2016-11-02" version="1">MSNPPPPSGHNAPSLDTVIHTLSPFDQAAPRFKCLLRSFVFRLSKLPSDKEFAIIKYNILERLEAVMLEYPFLRGYTKCGPDGLMELVPGPQDKPGSNRFRRSCPRVLLTSEDYADDFCRIRHRDSYSGLTAASIRDSGFPPLPSRDANHNYFFQEGRQPAMTLQADFLTGQDTCYLILSFAVLCTLADNASLDLIYKTFGVGLPPGDRPFSCVELNPLNHRLDLSLYRPARPSTVNRIPEWKGRRMQRIRPENLSASPVNVIFAISSGSVDDLVYLVNEYLKGKSKLRMDHDICVAAWCWVAITEARVWRLDPRAETCFGISINCRSKLRPPLPVTFFGNMTLKAFARTTVGALVGLQPLPPCCDPARFHRTKSPVETIAAAALLLREAIDSLNHEYICRRLWALSGATVSAIRNVSRSSNRKTRSNNEGVQFIPLSDFAAEMDFGIPFTAGGGLPIHCRQPAGLQEGVVYLLPRNASNGSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Y3</accession>
    <name>A0A1B7Y5Y3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyamine transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155926.1">
        <property type="nucleotide sequence ID" value="XM_018303903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Y3"/>
    <dbReference type="GeneID" id="28868010"/>
    <dbReference type="KEGG" id="chig:CH63R_08929"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08929"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="571" mass="63329" checksum="BCC3007FFB8E9A4C" modified="2016-11-02" version="1">MNFHSILTDLFGASLMSSNPHQEVVDDFDVRRHGGGMGVWLGIWTWCYIASLGFGFLIGAAVIDELQPAWGFYISIILVAVVLLLNTLCPEVRRSAFRRSVVEVRTGTDITRRVARGEIMMHRVKDGPRWWGQELYHGVALCFEMLRQPGFATMAVYSGWIYAQVVLIIVLLGSLSSRFYRMRSPYVGLMVAAMAFGAVVAIPFQKASYFSRARHTQVNTSRLTFDKQVTWTSHLLRRSVFAVGLPLAGLAYTLVSTGPPTHPSAPAIVAAMIGFLSCLAISECNGLIMETFDTSDLQPGMTGRHRGNSDIAQKKKNYSAYPRVTAGFAVCHSMGFIFAAGATALGGMAQRNLGQRAATGVVAGILLILTVMLLLCLVRFKEVVIIPESKTDEMEKWTAARRQSIKRRDSMPAGAVDDKDVIAEEEPWRPFIVGNPTNKTRRVNVLELGSMSRFTEIRKRNKLIDANQHLNRAALDAGLDALDDQISDIVSDIVSDAKDLVRRSSQRSQRSQRTSHSRRNHRGASSENSGNSSIEMTSVDDRLSLNSHRPRMPADVYNERECLRGQTVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6C3</accession>
    <name>A0A1B7Y6C3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_09074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156071.1">
        <property type="nucleotide sequence ID" value="XM_018304048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6C3"/>
    <dbReference type="GeneID" id="28868155"/>
    <dbReference type="KEGG" id="chig:CH63R_09074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09074"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="93"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="37812" checksum="ECBBA06890965E4C" modified="2016-11-02" version="1">MDSPPPPELKINPPLLNSANPWCTTFHDLERLHASPHTGALTTRTSLVGGAGFPHDDASHQYAFFDPSTARPSPAPNASTHKAPPDIGAENVASLNNLGYSPLPLETYLDFVRRLPDRKIPGGRHRHRKLIIISVTGSPAEVAECYRLIARFSRTTPHPLAMEVNLSCPNIADAAPPASDRAQLLAYLDALPRHPEIPVGLKTPPYTHPAHYSELIAALRQDATVVSPKSILKVPSRISFITAVNTLGSCLLLESAGDGEWDPRLPGSGLGGMAGTPLHPLALGNVKTITDLVSREPELLHIKVIGVGGVSDTDGFRRMKSVGAYAVGVGTALGREGVEVFEKIASGLEVVEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Q6</accession>
    <name>A0A1B7Y6Q6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156240.1">
        <property type="nucleotide sequence ID" value="XM_018304217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Q6"/>
    <dbReference type="GeneID" id="28868324"/>
    <dbReference type="KEGG" id="chig:CH63R_09243"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09243"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601383" description="chitinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="241"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="652" mass="70603" checksum="9E04D712A5E16FED" modified="2016-11-02" version="1">MHFHSRLSALLGLFHLISPLLAAENSSYFNLNSAFGLLGSDLPAQLLDLPVGTCNAETPCVNGACCSGITGLCGYSPAECGAGNCTSNCNAKAECGQYGVPGRQTCPLGVCCSQFGFCGSVDDFCNVDKGCQSDFGGCGPVKRPSCSKTGNSVQGRSIGYYESWANTRPCGKVSPEDLNLDGLTHVNFAFVFFDPVKFSIVPMDKNAGSLLSRFTALKERKPGLQTWVSVGGWSFNDHDRGGKAEDKANFVLLSKEIKEAFGKRYGYSITLPASYWYLQHFDLKNLQPHVDWFNLMSYDLHGTWDAASKFVGPYVATHTNMTEIDLGLDLLWRAGVKPKNVVLGQGFYGRSFTLEDSKCNKPNGVCRFSGGAKEGPCSKASGILNLQEIMDIIKDKKLEPVHDEKSGTKWIHWDNDQWVSYDDGETLGQKAEFANSRCLGGLMVWALDQVAQDAASLLNPDDMDEEALLEAEVIYQDEAAKGVCYTTKCGEKCRNGDHEATQTNGQPGTLSTMDRCPKDEFRSVCCSKGSVMGTCRWRGYRGLAMSCMGGCAEGEVSITENSNSRTDKEDQSCTGGTQTYCCNGFKPPISKEQITETIKDEATDAAIAAAEALALEVAAKAFCRIAIMAATAPLRFIPFVGKSSSKVNILFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7L9</accession>
    <name>A0A1B7Y7L9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vanillyl-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_09547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156544.1">
        <property type="nucleotide sequence ID" value="XM_018304521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7L9"/>
    <dbReference type="GeneID" id="28868628"/>
    <dbReference type="KEGG" id="chig:CH63R_09547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09547"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="625" mass="68803" checksum="2E3A6837367B8E8B" modified="2016-11-02" version="1">MSAPTVVTSDGPPAGPPTKSLPSLLPPRMLPPGVEQDSFQAFAQRVVSVVGASNLEIIAGDTPLENDDFGETCFKYDRYRSADNEALLLGCAVVHPRHVADVKAVLALCTSFNVPLWPVSAGRNLAYGGAAPRVPGSLVMRLGTHMNRILDVDTAHFTCVVEPGVTYQQLHNHLKEKGLLDKVRLDTPEVPWGSMIGNALDRGGGATPYGDHWGTHSGMEVVMPDGDVVRTGMGAMSSPEGRREAAQGVPPEDQTPNSCWTLFPYGFGPINDGLFSQGSVGIVTKMGFWLMPNFPGITPFMVTYARDEDIQAAVEIVGKLRLHHVLAHSCSIRYITLDTGFYSPRAAFTDSPKDVILTEEELDAMCARNTLGRWNFTGCVYGPPKIRELTMQVIREEMTKPAGSRLYTLDDRTERPSMLHGRAPNMEGLCNMDQQNWIKQWMPNAAHILFTPVSRIDGGSALEQFQLAKALFAEYQMDFFGHLAVYHRDMHNVSCIVYDSEDAAMRGRAWDLARRLIDEWQKRGWGEMRTHIGLHDQVAASYDFNNRAMLRLNEKVKEMLDPKGIIAPGKSGIWPRGYDRGKYLMGKDHIDAFPGVEGALLRGGPKADARGSGGRSSHLQEPTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y891</accession>
    <name>A0A1B7Y891_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156760.1">
        <property type="nucleotide sequence ID" value="XM_018301982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y891"/>
    <dbReference type="GeneID" id="28866089"/>
    <dbReference type="KEGG" id="chig:CH63R_07007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07007"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="238" mass="25736" checksum="D3EC09BF51425FE5" modified="2016-11-02" version="1">MSLRTLGAKAAAALDKDLMSTGAFSLDQLMELAGLSVSQAVYRVHPPSRGVNVLIACGPGNNGGDGLVAARHLRHYGYKPTIYYPKRSKNDLYQVSEVSFDFVYLDVPFVDDFPAALKSTDHVVDAIFGFSFSGEVREPFPAVIRALEETKLPVTSVDAPSSWNIEDGPPSSGPGSSFQPAVLVSLTAPKPLVKHFKGRHFIGGRFVSPGIAEKYNLDIPQYEGIDQVVEVDIKGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9I0</accession>
    <name>A0A1B7Y9I0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_07477</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157230.1">
        <property type="nucleotide sequence ID" value="XM_018302452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9I0"/>
    <dbReference type="GeneID" id="28866559"/>
    <dbReference type="KEGG" id="chig:CH63R_07477"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07477"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="460" mass="49788" checksum="A357995BEDBDFBF5" modified="2016-11-02" version="1">MGKEEKAHINVVVIGHVDSGKSTTTGHLIYQCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTTKWSEARYEEIIKETSSFIKKVGYNPKTVAFVPISGFHGDNMLAPTTNAPWYKGWEKETKAGKSSGKTLLEAIDSIDQPKRPTDKPLRLPLQDVYKIGGIGTVPVGRIETGVLKPGMVVTFAPANVTTEVKSVEMHHEQLTEGLPGDNVGFNVKNVSVKDIRRGNVAGDSKNDPPAGAASFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSEILEKIDRRTGKSVENNPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKASAAAGKVTKSAAKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA67</accession>
    <name>A0A1B7YA67_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157470.1">
        <property type="nucleotide sequence ID" value="XM_018302692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA67"/>
    <dbReference type="GeneID" id="28866799"/>
    <dbReference type="KEGG" id="chig:CH63R_07717"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07717"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="257" mass="29697" checksum="C05BBC450533BC79" modified="2016-11-02" version="1">MADQKPWADGPFELISSTRAGSKKGAKTAGANRMAEDMTIIHNLIIRILNTVYLQCVNVEKSPDDIPDFVSYAIEWARMVEEHHHTEEETVFPQIERLAGVPGLMQANVAQHEAFHDGLHAYMGYLEKVHKSDEAYSGERLRSIIDSFMPTLRQHLSDEIDTLLKLGDYDRDWEAWFEKLVKELLAKRGDPNLKTTTIPLLLTNRDTTFEDGIYAWWPPLPWFVPLMMRWFLIPAHKNWWRFSSCDDRGAPKELPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA85</accession>
    <name>A0A1B7YA85_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="7">1.8.5.1</ecNumber>
            <ecNumber evidence="8">2.5.1.18</ecNumber>
            <ecNumber evidence="9">6.2.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ubiquitin-activating enzyme E1 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CH63R_07731</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="7"/>
    <dbReference type="EC" id="2.5.1.18" evidence="8"/>
    <dbReference type="EC" id="6.2.1.45" evidence="9"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157483.1">
        <property type="nucleotide sequence ID" value="XM_018302705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28866812"/>
    <dbReference type="KEGG" id="chig:CH63R_07731"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07731"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 25" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 25" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="GST C-terminal" evidence="28">
        <location>
            <begin position="1283"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="1314"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="24">
        <location>
            <position position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OBR08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1448" mass="162457" checksum="69F7EB5F7AC4A899" modified="2016-11-02" version="1">MAVSLSPTPSPLELLIRDSVPRSAGNVPTTCSHYVANPSFSLQDKKLPEVDLVTRMQVDDSVVGLTEIDESLYSRQLYVLGHEAMKRMGASNILIVGLKGLGVEIAKNIALAGVKSLTLYDPGLVALADLSSQFFLRPEDVGKPRDEITAPRVAELNAYTPVKVHQSSNLGENLSQFDKYQVVVLTSLPLKLQTLIGDYCHSKGIYVVAADTFGLFGSIFCDFGDNFTVIDPTGETPLSGIVAGIDEEGVVSALDETRHGLEDGDFVTFSEVEGMEGLNGGEPRKITVKGPYTFSIGDVSGLGQYKRGGLYQQVKMPKTINFKSITAAIKEPEFIVSDFAKFDRPQQLHLGFQALHAFVESQGRFPNPLDDADATVILRSAEAFAKAEGVEVEFDEKLLKELSYQALGDLNPMAALFGGIAAQEILKAVSGKFQPIQQWMYFDSLESLPTSTPRTAELCKPLGSRYDGQIVVFGRDYQEKIGNLRQFLVGAGAIGCEMLKNWAMIGLGTGPKGKITVTDMDSIEKSNLNRQFLFRPKDVGKMKSDCAAEAVQAMNPDLNGHIVCLKDRVSPETEETFNEEFWNDLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVLPHLTESYSSSQDPPEKEFPMCTVKSFPNKIEHTIAWSKDHMFENLFITSPSTVNLYLTQPNYVESTLKQGGSAKLTLETLRDYLTTDRPRTFEDCIAWARILFEKEFNNKIQQLLYNFPKDSVTSSGTPFWSGPKRAPEPLKFNPNDPTHFAFIVSAANLHAFNYNIKSPGTSKDIYLRELENVIVPEFSPAEGVKIQANENDPDPNAEAGQTSSFDDNDELQNIISSLPSPNELAGFQLQPVDFEKDDDSNHHIDFITACSNLRAANYKIEQADRHKTKFIAGKIIPAIATTTALVTGLVILELYKVIDGKQDLEQYKNGFINLALPFFGFSEPIASPKVEFKGPNGIVKLDKIWDRFEVADITLKELLEHFEKQGLTISMLSSGVSLLYASFFPPAKLKDRQNLKLSQLVETVSKKPVPAHQKEVIFEMVAEDVDGEDVEVPQFVRVFSSTAVTRQAFLRTPLTPPKGLAQKQQIRMTSKVTDWVKPGDTSGEFKRQQSSFRNWISREQGAKFPPEKGRYHLYVSYAWKPQKTQACRTLITRKLKGLEDIISYSVVHWHLGEKGWRFVTEKDKDIPGDNVIPDPVPGHEDFRHLRDLYFESEPEYNGRFTVPVLYDTKGKTIVSNESSEIIRMLYTEFDDLVDKKYQQVDLYPEALRVQIDETNEWTYDKINNGVYKSGFATTQEAYERNVVALFEALDKAEAQLKSVHEKGPYYFGKDITEADIRLFVTIIRFDPVYVQHFKCNIRDIRSGYPYIHKWMRNLYWNVPAFKDTTQFEHIKWHYTKSHTQINPFSISPVGPLPDILPLDQEVAAVSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAG9</accession>
    <name>A0A1B7YAG9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoxI translation protein CYA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157504.1">
        <property type="nucleotide sequence ID" value="XM_018302726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAG9"/>
    <dbReference type="GeneID" id="28866833"/>
    <dbReference type="KEGG" id="chig:CH63R_07752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07752"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="4">
        <location>
            <begin position="576"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129401" checksum="5A56AF718483FEC0" modified="2016-11-02" version="1">MLERTAATLESCTSFHALPSASRSLKTQRKLYTGFWQHGAAAIDISCSVLATQLNAASSPPPQPPTPPPETLAASTFLLDFLYPTGTAAVLRKFAPGLANHQASIHRLPRRSRPFTSSVATPTNLDTRSMQYDQDTTTHAAKETRLGQEDFDPAEDQEYEDEEDDKDEDEAAVVSWRHTHSGPSYLGAGSRPDLMRELMAEKDTEYFGSIWQLYSQLDRSLQPELRPEVIVYLYRSSNVIDARRILLLFSEIETDQWTPKVLTSAVAASLRLEHVSEAFALYRRGLDANGTVSGLKELLQYAFKRSAWKTVKDLWVAHHTSDAYRDDDLAPVEALSAIPNIGELVNQFASYVTSTGKMGKDAQKRLGILLEQAIQVALQQPCKPKEALPLLKIINSPKMYADHLNQALARGQRECLPEIYRLYRDMPNATLSPELLHGMFDVFNPDDVLGLEQVYEDFSKTSYRGLDKLAVKKYLRFYASRGDIKSVERLSAKYPKILKVTTRSLYLMNAYASLGDYEGAREVLDEMRYKHRKKPTLRHWHELLKSCLREATYDRPRMVFDELCEAVKPNEVTFATMMSLAASKGDLDFTLQLLQQARSRGITTDVPILQSVVGAYCRNDRLREALATCIEAKNTNVPGEQARLWNVLLRRHADRRAFDDVCEVVALMGQHGVMWTPETHAVLLQALVACGQADPAYKVLQAAVHDKSFAPIPGHFVTVTEGGLNSRQLWLARNSDKLMRRVTGRPSSVDARLAEARLLFKQQLFSTLQTLEQADGPNDLMDDLRKMAEEVKTATQTDADPGNGAHRALKRADSLHRLRGMLVKAIALFTRYRDFESARELRELQANLDQEGITTTPKDEQLDILHSLMLENIQNKKYDAAKANWKLIWQTTLELARPASYSGHGPFVALPRYRYSLSRPFGTLQEMLLELQDSESLKEALDQLLDAGFLLDARAMNHACQALARTGRWLDACKLCEKYLMDNWTGWLLNRMKRRLKVNLPLSHRRQGRAPHRLRPTSYTLVVLAKGYSDLEGMVAWSSTAAWAMRTLQKHCPQLVHAIQTLSYTGLGIENEAFDRDRAMELAKKELEEPQEMALADEQTDAACVTEEQPSAGQQEQVSATKDDADESLANEGASSPVTGEESRLDGQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAV1</accession>
    <name>A0A1B7YAV1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_07967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157719.1">
        <property type="nucleotide sequence ID" value="XM_018302941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAV1"/>
    <dbReference type="GeneID" id="28867048"/>
    <dbReference type="KEGG" id="chig:CH63R_07967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07967"/>
    <dbReference type="OrthoDB" id="4843970at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR09202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="470" mass="51758" checksum="290FA42ACA608339" modified="2016-11-02" version="1">MSVSANQADPRERELEHVRIHRQCGACGFLFDVGDRLVAPDRYNLRRLASLPNEVATIIWNFLGHHSLLRFSAVLEAIDYLSTASDEPTSVPIARIEVWHRGSQPITSTVGSNCPIELTIDSKGIARIARLASSVQESWSRFTVYTTVDAGQNLTVDFRFGISRLASPCGPNQLQITDIPNLSKFKWFYFPFQASTTRLASIDLVSCSGITFFLLASDLLAVHAHTQASPSAEVTFARLSPTIRSQVQWFYVPNPTADKISAFGVRLAALPNGRLLLNSRSYCIRTPHRGNIAIGPYNEEDASQEYAVYTPDRSILVYAIPEHGPVVFLGAITEGRKCSGLRPSIPSVSSLPNASYASATLTDVTCIWVFRESQTDFCRGLIVQYANGSEQALGYCRLGYDPTERCADVSQFAFAALECKMENGLSRRIVKVKVSAALRDGGYLGQDWTRCSNGCTLEVWATGTEMVMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBF4</accession>
    <name>A0A1B7YBF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Subtilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_08167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157919.1">
        <property type="nucleotide sequence ID" value="XM_018303141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBF4"/>
    <dbReference type="GeneID" id="28867248"/>
    <dbReference type="KEGG" id="chig:CH63R_08167"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08167"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601505" evidence="9">
        <location>
            <begin position="20"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="147"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="611"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR09402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="929" mass="99412" checksum="82F9D1AE68FDD7D0" modified="2016-11-02" version="1">MRFASVVVSVLALAGTGAAKVSRRAVSNEEDVRPSNDTVVAPKKFIIELDQAADKDAVVRQLQARPGSRVLKVFDSAVFRGVAVESDSENTDSLEALAPVVKAWHSTRVQLAPVVAGESFSDDARAPDYAIHWMTGVDKLHEQGILGKGVKVGVVDTGVEYTHPALGGCFGAGCKIAGGYDFVGDNTYWPYPGEERQPDEDPMDSVGHGTHVTGIIAGKSAEFTGVAPEATIYSYKVFGPNEGTGEEVLIEAFLRAFDDGVDIITASVGSTGGWSDNAWALVASRIVEQGVVVTIAAGNSGDVGPFFASSGAAGTNVLAVGSADTYVVSARQFAGTFTLDGHSNRTILGYRPAEELFPPEIVGWPIVPVTLNLTVENDACEPLPEGLNFTGVIPLVRFDEGCQDHIRQRWVQERGARFMLFYLTDRPVVGFSGSGWAQSDWGLLSKDAGEAIVKTVLAGGTVTADFSLDQTSNYVAMYNAGGGRPSVFTSWGGTFDLELKPDITAPGGRIFAPFVGLGYRDSSGTSMACPYVAGVAALYIAAHGGRSVHGAGFAKALHARIVASGRAVPWSDGTTKDFGFWAPPLQVGSGLVDAVAVLGATSQLSGETKFALNDTHHFSRYHQVDITNTGATELEYVFTVQDAGGFESYWTAEAGAAAGVYAAPRIKDLVEIEPFRIGVPVSVPSGTFKIAPGQTKTAKFSFDIPKGIEASKLPVFSGKILIGSSAGDVLSVPYYGVGGSVKHEIADMFYRSVGYPRVISGVNRTLLSEKSSFTFDLSLDKQDFVKLSVALTWGTRQLRWDIFEPTYQEREWTYPPIVGENKYIGSVASFNVYNSVNYPVFDPATDSVNNTFSYPLQDQPRDSPYESWWLGKLADGSQIKPGKYKWRIAALKPFGNPKASDNWEIYETPLIEVLPLTGGSNSTAALRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBJ4</accession>
    <name>A0A1B7YBJ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G2-specific serine threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157963.1">
        <property type="nucleotide sequence ID" value="XM_018303185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBJ4"/>
    <dbReference type="GeneID" id="28867292"/>
    <dbReference type="KEGG" id="chig:CH63R_08211"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08211"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="442" mass="50265" checksum="EDDB67DD5D923E96" modified="2016-11-02" version="1">MEDPDHPQPPFQLVKRVQDNIWLTRRIAQDPGHADGEEFIARKVDDFDEYYEAGKYSMSFTTKRQRQVKGLMDLLYDGNLGRNVSHILNHENIISLAGYLRQRPVHPHVDAIEDYLVWDICDAGTLENLLAERDCEREPGCFLPESLCWHVLVSAMRALAWLHDGYRQEVDWVTGERCWKKTDAEWMPILHRGINAQTVFFQHPRGRETYGVCKLGKFGKAFVSGVPARRDGAPKGETPLPHSIGFPIAPKEGHKSLTDMTKQWKEYLVTGRNSKRLYTLSDEHWALGAVLFRMMVGSPLPSLDGCKKCRCIHIQRCAKVDCVYQGKHGGGGECQQHETFRGCRCPTPCSAEEDVHIDETLHRVGYSPYMVLAVRMLLNYDLEAPAVGTKALADEVEVLYRRWRGETEDGREYIDVEDDLGYRFLVLNNAAGAVATGEAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD49</accession>
    <name>A0A1B7YD49_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Upf0183 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158464.1">
        <property type="nucleotide sequence ID" value="XM_018300614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD49"/>
    <dbReference type="GeneID" id="28864721"/>
    <dbReference type="KEGG" id="chig:CH63R_05639"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05639"/>
    <dbReference type="OrthoDB" id="5402622at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1251" mass="139167" checksum="F9F0AA200583ABAA" modified="2016-11-02" version="1">MTEKDAAQQRAVLTRKLSPHSMPGDRGSSRGSYETGESSAAGSILHDTTLLPSPDEPNGRRPLSSSPRDAEDTNGYHGKDARKQRAQRHRSKGAFLLQDAIRHEDDSDRDQAPRLRHVRNLPPSRRTNDHTRTSDKSGSSAGREAGLGLAGLDSLAGQDGDVSPTQPTHNLTVRKRDAPNGRPLSGTSFTPAANTLLDIDSAQIVNMALNLSESRRQVSRRIAPPQAVPTLAQLPDGTTGANLKSHLQQQRRISRTRSPGPDKALTPRLPSTGVLSSPLQATFDMSRESTFRNHFTASTLARAQKAKEHLELMAQYRRFLELVPPIQPHHHQSRPTTASPPTSSGGVARVSTYGSSDGTVRLGRPYNPLQYIRNRKVRARERKAIDGEGQGFGDIMKVADWVDEVAKWAATGQTGVDGCTLPPFADADASENALQLAANANKPRRPRLDWIVDAADLLADAYWLEQDHHKQLIEDRHWRRIFPQNVDLHRPLSRQNNEHGSESGRTSVHRESEELGPALDPRTSNPKLVKSDTEHSTGSARERARQKLHDLTGHHHHRHSSSMHSHHDWRHGKTSSDFSDNENEARPKDRRSRKGTLTSSHQDILEKQMLEMIAKEARENGPRRPGGSGYVTPERQAGAGSYPPSRQHSRKASIAEVSESDERKSKDKPRFTPLHLQRPTRSSLEIPATARRSSFEIDSSLPNSPDGAVRGDPFIPALGGDLSPGSSRANSPTRNPFVKVRQIFRERSRDRIDDRISEEKSSAEYVASAPRTPVEASPESSGERRSTDWRGSSQSPSRKVVQRQTGESHKSHRSVASVKLRSDDPGIRGLFKGARFDNVIRGGVSKLGDLIWRKESDTGDLLSEVEGTTTDESDTEQRGRRKRGEIPLSRTASIRSQGLRQQTTKSYLDVMPTFESASANKLRHTESEPAHLPDNSPPSASRKSPRFDRLKPPRIDIMNASPTSSPGSHKRLSDVSESEVLSGGRIADVKEADKRLNSIIAMPPFVPDGRPGSASNRSRHWSISDHSPAPERAPMSKREVARLRALVLSSGIKAMEITRRANEPQLVFADRPRLSQNDFTVANVFWPEVAKLSPDPANVRSKAVSQTELYQFAAKTLGNSIQCAGQDWQKAADLFVSDTVPALHRRVEDVRRRVATDLSAMTRAAADEADETSRDLTLGQRLKIKHTLDVIETMLRRRRRRFRWVRRAMWLAVEWVLVGFMWYVWFVVMILRVFWGVGQGAVGAVRWLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDJ5</accession>
    <name>A0A1B7YDJ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158673.1">
        <property type="nucleotide sequence ID" value="XM_018300823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDJ5"/>
    <dbReference type="GeneID" id="28864930"/>
    <dbReference type="KEGG" id="chig:CH63R_05848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05848"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="159" mass="17337" checksum="E7836EF5563B75BA" modified="2016-11-02" version="1">MNTFRPVAGRIGSSLTGGITKLHTPMLRRYALGFSAGAARPLGTMSSATPVEDAIRSKVAAAFSPTTLEIYNDSHLHSHHKAMAGSTSKETHFRLVITSEAFKSKMQSARHRMVYALLREEMAREGGIHALQLKTLTPEEEERQKAKKAAEAQSSEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGD8</accession>
    <name>A0A1B7YGD8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159660.1">
        <property type="nucleotide sequence ID" value="XM_018301810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGD8"/>
    <dbReference type="GeneID" id="28865917"/>
    <dbReference type="KEGG" id="chig:CH63R_06835"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06835"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="110" mass="11810" checksum="0EBFB33F70B310E6" modified="2016-11-02" version="1">MMEEEEEEDDDAIPSGFSYKATDAVEETRDQSKKPGEDGYSMCYYLRVKVTTQTSLPPTTTTAAAAAAAAAASLTVIVATAIHRPGRPITRGSIGVRLCKASGRRSRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGX6</accession>
    <name>A0A1B7YGX6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159928.1">
        <property type="nucleotide sequence ID" value="XM_018298682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGX6"/>
    <dbReference type="GeneID" id="28862789"/>
    <dbReference type="KEGG" id="chig:CH63R_03707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03707"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="339" mass="37258" checksum="BC26E9946EB25604" modified="2016-11-02" version="1">MTPQWNPLSEMPDLRGKVAVVTGGNSDIGREVVRLLAWKGAKVYFTTRSEAKALEARKRIQDAYPDIEPDNLQCMTLDVADLRSITSVADKLMEKERKVDVLIHAAAAGTTSTDLVGPGWEVHMATNLIGPFVFTNRLLPLLKNAVREPGSDVRVVTMSSSAQTAMVPSSYKFRFTTADFLRNPVPSPPWQWRYLGRFIFGFDTTRYGVSKAANAVFAQELQRRLDEQKLPIVSLAVHPGEVATAGVDRINTALVRAISHLTFVSPEQGAATPVFAAVAKEVRQDPLKYNGKFVFPVGALGQPHAVASDEKQVQGLWQNTTAEVNKHLQAEGLPLLSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHI0</accession>
    <name>A0A1B7YHI0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159861.1">
        <property type="nucleotide sequence ID" value="XM_018298615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHI0"/>
    <dbReference type="GeneID" id="28862722"/>
    <dbReference type="KEGG" id="chig:CH63R_03640"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03640"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="277" mass="30948" checksum="14DA6557F6C2AB8F" modified="2016-11-02" version="1">MELTAYRSLKTSSDSGVLVVTFHNPDSPEYNFWGRDTQEELKDLVKKLDADDETKVVIFKSDAPKFFVAHLDVTILDGSDPIFIEEFAALLHSITTLRQVTIGAIEGRARGAGSEFLASLDMRFATRSPETLIAHQEICNGLIPGGGASQFLTHLVGRARALEYILTGKDINAADAEKIGWINKSFANSEEMYAYISQQTSRLRLFPLTALHEIKKAVNRHSVPSREDIVSEGTAFRRQYRDPQTQAVLTKTWEVLASIPQMEAELDLPSLVPQFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHW5</accession>
    <name>A0A1B7YHW5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160067.1">
        <property type="nucleotide sequence ID" value="XM_018298821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHW5"/>
    <dbReference type="GeneID" id="28862928"/>
    <dbReference type="KEGG" id="chig:CH63R_03846"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03846"/>
    <dbReference type="OrthoDB" id="4760011at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="998" mass="107391" checksum="4D36DB7E48032A4F" modified="2016-11-02" version="1">MSRLFLLAREDSEGGSGGGGGGGVMTLPILLAVAIGGGVLLFICLAYLLIALAGRRHRRVARTRSATPGVRLDLESEGGSIRTPSPLPRPRRLTKQKPGETYADMAEIQGKPYRSLSSLMLPRGKTFGGGHDEDAGGYQRGGHIRRNNSWIDEDAIHGPRVQNDGKRLSIRDSFILRTPTLPDLFGHHGHKEDGDFRHDHTNYPLQQPRPVSLPAQRSHAPRMPLPRTASYELAEKLAAAARGGVPPSPQTFQQGPPGPPGQRPVPLQRLRHKTTESDLAEILRSTEERLQNGTPSNSRPATRQRAASASAGSSIKTQQASPTKSHSPAKAQSSVRSLSPEKNQSPARSQSSLKSQMITHVGHALDVDAQRVTTSRTPSPSKRMVAVPMLAATPAHQHRRNISQCSANSDADSLFGETTPEVEHTQPTGLSSPSRRSDSNSPTKPTENGESVESPGSDASSSLSTLYSVNEPEDDSKTGGTRKPEGIVRGRKPRGLVIDTQISDPFVTSGPPEVPLRSPKRQSSSLPPLRRLTPPEQDVVKETIVYAPFHSRSASNSPVPRPLDVVKRGNVAAGQSQPHDALTMYPSDMAPSPETVQPKSVTSMKPVFLVSSTSVGSMQATPGTSPEDNCRPPKPGNNNNNNNNNNNNNNNNNNNNNNNNNRLTFGQKGTVLPPPLDLRPGQGSPNREAVVMGSPESLLRGRTPPTTRSGSGSRTPTSPTRRPLPSPDLSTGSPTPRRHKRRGLASPIRDRALSRQPQIKENRVLSSSEYPSIVLKPAASPKRNSSHRDFAVMGLQSTVAQLRRMNSQMSTFSAGSSVSDPESPTLPNLRGGGFSPDRSNSRVSKMGRQNYLSLGASPKSRRSTRLSIRSARNSIAVLKGRPGANKHLDSLRVAVEEKEAEAREGSLIRGPRPLILTPRRAGRGSPGQTDAATDSPTRRRTAHIDGGDQKHLEKASKRNGVYDSTAVLDMYPKDARLLSSPKSSAAAGTKRRSPSTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIN7</accession>
    <name>A0A1B7YIN7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp70-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160460.1">
        <property type="nucleotide sequence ID" value="XM_018299214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIN7"/>
    <dbReference type="GeneID" id="28863321"/>
    <dbReference type="KEGG" id="chig:CH63R_04239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04239"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="23174" checksum="499F130AB69AA043" modified="2016-11-02" version="1">MDKNLNDLLKWSIENGSASQNGEAAPAAAPASNLNPEAIAALFGSGPSDAELMKLSMEAITSADPEITLENKLIAFDNFEQLIENLDNANNIAKLSLWTPLLGCLDHEEDEIRRMAAWCVGTAVQNNQPSQERLLAVGGIPPLLTLAIKDGEKEAVRRKAIYALSSAVRNYQPAMNVLTDELEKKGIRSGKVDAENMDNVDEVMNELKAKITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKU4</accession>
    <name>A0A1B7YKU4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase SUV3, mitochondrial</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_04969</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161190.1">
        <property type="nucleotide sequence ID" value="XM_018299944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKU4"/>
    <dbReference type="GeneID" id="28864051"/>
    <dbReference type="KEGG" id="chig:CH63R_04969"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04969"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001549">
        <property type="entry name" value="SUV3p ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="337"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="704"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="761" mass="85696" checksum="817F26CDFEFA1B70" modified="2016-11-02" version="1">MRTVLRAAKICAAGSRLAPSHGFATSSPAAFKAATALCSSKKYTPVESKKSKYDVFRTMILTQFNVVLNNMGGWSETNREFQNFGIRSEHGLNNEIALFRETIQKSIHLANKGATLRKENPLFWSLRNAFIRGDVKGLTSELRYSFQSFMLRSRLEKSSPRQKKLADLRFPQEWFPATRAIQRTIHLHVGPTNSGKTYRALKALENAKSGIYGGPLRLLAHEIYSRFQAKGRPCAMITGEEQRIPDSDNYFISCTVEMTPLNRLVDVAVLDEIQMISDRDRGWAWSQALLGVMAKEVHLCGEERVVDLIKSICSSIGEKCIVHRYQRLSPLQTMKKSLKNDLTKLRKGDAVVAFTRVNLHGLKNAIEDATGRRCAIVYGSLPPETRAQQAALFNDPDNEYDFLVASDAIGMGLNLEIKRVIFETATKHDGTQYRTLTTSEIKQIGGRAGRYKTARQAATDPNGTAAPEEKMGYVTTLVDDDLPIIEKAFNSETQPLDVATIHPPASVIEQFSEYFPPDTPLSFILLRLRELAPVSQRYSVYISELSLEIADAIQEFPMTIQERITILHAPASLREPGMRAIIKAVAKCISTRTGGALYDIQPINLELLDATLDDFSNQGRRYLHSIEALHQAITIYLWVSYRFPNIFTSQALAFHVKDAVEEKIEFYLENNTVFDADVHGKARDRQRREALQKQLEQELLMAEQLESPEGENELVDSEPSDEGPGQWISPGHEEPLVDDESEYEELQDRPRSEPVPRQESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKU9</accession>
    <name>A0A1B7YKU9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161188.1">
        <property type="nucleotide sequence ID" value="XM_018299942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKU9"/>
    <dbReference type="GeneID" id="28864049"/>
    <dbReference type="KEGG" id="chig:CH63R_04967"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04967"/>
    <dbReference type="OrthoDB" id="5325276at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="810" mass="87733" checksum="AFCC29358EC38704" modified="2016-11-02" version="1">MGILKFFSSKRLSDKPSNGIKVQAYDATTASLPPLLGTYPVAGNGPTNVFENLQRSHHKMSETNLSLAAGSDTAAPAPPVPRFRDASVERPSSAPGSAMFDASPSGRRGRDSSRGSPLSFRKSRVGSVPSTTSGLSPTPKRKTNSPAVPFEGDPFRPPAAPFSHSRHFSLQNTGMAARGFIDLLDAQSEIKPSGFQSRVKASGVRDYGEDVADRNIGENGVDLTSERVRAFYASTSTPRAQYTGVFASTSARGSPTDKHERFQPSRRLHSMDTEGRTKSLTTSSAQVPFRTNMFNPEGSLSREPIMESVAESVRVRRRQSLGAYIPVTPSSLAADGALDAHRLTVDTDGPQRVRQHKRRSTLSGEAPMNELGIFSASGGANAESSSSSKTPPKPAYLVKHNYSLPVQQRPKTSGHTPVESYQGVRPPSRAGSVASSKFSSPTQKSPSQQHTLFAKGVAARQTERPQRAMPDGGSGTRGWVGRVEVEGFVDSADVASPAPSPHVMRSGHSWRENLDDSCQRPNFHGSPYGKGKLDEIYEHVPLRGSSLHHWSASSATPTMSSTSSFPRPHSRHTTTTSVDLATMSSFMNDSHSSLFSGTGDHTSFRTALESALPSPIDLAASGGGFNIDDYLSSDDDIDADSFITTRKRDSAHSGGHEDELLFSDKGYGEGGLQLPGLFDSLCNVPDPDTTSPERPGLRYSLSNTSRFAKRLSLDPWIEAPTSPLDEGEDEDDDIYDIPMRSDLALGRRGTRRISALGTMYQSIEEEKEEKVDVRTAVRLRKEAKARQRAMTRRSKSQQRHPDDIEEKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKW5</accession>
    <name>A0A1B7YKW5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161101.1">
        <property type="nucleotide sequence ID" value="XM_018299855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKW5"/>
    <dbReference type="GeneID" id="28863962"/>
    <dbReference type="KEGG" id="chig:CH63R_04880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04880"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="590" mass="63422" checksum="46F920D311413E51" modified="2016-11-02" version="1">MSRYSKAALRALAARATTSSLADVCTVENVQNALPSNGTLLGIDLLPSTVTASPVYNATTGGGMMGGSSSGTTYTYCNVTVHYTHNGKGDTVVVKYALPSPTDFKSRFYVAGGGGFSLSSDATGGLSYGAAGGASDAGYDAFSNSYDEVVLYGNGSINWDATHMFGYQALGEMTQVGKALTKGFYSMGADDKVYTYFEGCSDGGREGMSQVQRWGEEYDGVIAGAPAFRFAQQQVLHVYSSAVEHTQDYYPPPCELAKIVNATIAACDGLDGRTDGVVSRTDLCKLQFDLKSVVGEPYYCAEKNSTSLGFGFNKRQAQGSTTSYQPAQNGTVSEQGVAVAQAIYDGVFNSEGQRAYLSWQIGSELGDASTTYNSETDAWELSIPSTGGEYVTKFVQLLDLDNLSDLNNVTYDTLVDWMNIGMIRYTDSLQTTLPDLTPFQASGGKLLHYHGESDSSIPAASSVHYWQSVRSVMYPNASDAEALESLADWYQFYLVPGAGHCGTNSLQPGPYPLSNMATMIDWVEGGNKPSRLNATVSSSTNVNAGETQMLCQWPTRPLWRGNSSDFDCVNDEKSIDSWTYTFPAFKIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL21</accession>
    <name>A0A1B7YL21_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_05032</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161253.1">
        <property type="nucleotide sequence ID" value="XM_018300007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL21"/>
    <dbReference type="GeneID" id="28864114"/>
    <dbReference type="KEGG" id="chig:CH63R_05032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05032"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="390" mass="41936" checksum="A55B6BD32CE6F883" modified="2016-11-02" version="1">MLARTLRVAGASPGSAAAAAAAAARAHQQQQLRTACSSSSSSAGPETLPSSPIRVFRSVSALRTWRRPHVVNYRSVGLVPTMGALHEGHLSLIRAAARENHHVVVSLYVNPAQFGASEDLASYPVTWARDADVLRNLDRELADDGANLGRVSAVFAPTTAEMYPSGFPGQEVGSKGSFVTITPVGEVLEGASRPTFFRGVATVCMKLFNIVQPERVYFGQKDVQQTVIIRRMVEDFMLPMEVVVGDTMREADGLALSSRNVYLGERRRKVATVLSRALRAAEEKYRQGALGREAILGAANQVAAAVLSEQSRLAPKDRVMFEVDYISLADPDSMQEINTVVPTKGGILSGAVKMLPVEEPQPGEDLGHSNGPAVRLIDNIILKPDQTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLB1</accession>
    <name>A0A1B7YLB1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161350.1">
        <property type="nucleotide sequence ID" value="XM_018300104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLB1"/>
    <dbReference type="GeneID" id="28864211"/>
    <dbReference type="KEGG" id="chig:CH63R_05129"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05129"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="50" mass="5703" checksum="D116CDAA2EAA377A" modified="2016-11-02" version="1">MVATLSVGDPDGRRGQEKGNMRRHFGLFQSLRQSLSRLVHVPKPNQARSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLI9</accession>
    <name>A0A1B7YLI9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161392.1">
        <property type="nucleotide sequence ID" value="XM_018300146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28864253"/>
    <dbReference type="KEGG" id="chig:CH63R_05171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05171"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1284" mass="141195" checksum="5862B52D931F90CB" modified="2016-11-02" version="1">MAEQDQEVNGQGYATNGRNGAANGRSEPNGYESAFEETTEPFEGYDKSGGMFDPATGTYPRISRPVELIRPSYDVVVIGSGYGGAVAASRMARGNKQVCLLERGKEKWPGEFPSGIAASSKELHTTNAATDGVLGSLGLHGVGHDPTGLYHLIVGDGQNAFVANGLGGTSLLNANVFLPADDGVLSLPMWPEQLKGDELKPYYERAAEVLEPKKYPQDFPKLAKLETLEKQAKLMGWGDKFDRVPQTTRFEDGENSTGVYMRASTLSGQDTTGLNDGSKSTTLVNYLSDAWNWGAEMFCQCEVRYVTEAEDREGYIVHFAWHGGKRANFKDIFYEDLMWVHAKELVFFGAGSIGTTEILLRSKKFGLQMSNDVGHGMSGNGDILAFGYNTSEYVNGIGRPDPPPNRPVGPCITGIIDCRHDLDNPLDGFVIEEGAVPAALAPFYRLMLTYLPYRKFPSNISIKGMFGHVAAAYGSRIFGPYFAEGSTEKTQCYLIMSHDSSQATMQLHKDRIMINYSGVGKSHRAKKLAGYLAKLTNLIGGIYVDSPFYAAFGEKEITVHAIGGARISNDDTGASGGVNDKGQLFVGEGREVHKGLVVCDGTIVPAALGVNPFATITALAERSVEKVAEEFGINVDLKTKNGSLNLFAEPAYNQFEHEDDNFQVARVREIIKTARDDKTPGIAFTEMMDGWIHFGEDAETLDFERATETAKSRGEYARFFLSARSWNTHNLVNDKEHEANLTGTFTCPALGGTSMVQGGKFQLFNDDPRSPDTMNLTYNFLVSQKDGSKLHFNGYKVVNSDVVFNPLNLWKATTTLYCTITEVDDQDQPMPDHVRGKGVIHIRPTKFLQECTTMEATGSTLYAKVASTANFLGYFTAKAAGAFLTPFIPQQWPSLPFHSYQNPTPWSEEMTVEANDRVKTKLYMWGPQGLSGQAADDAPILLLIPGAAVDHQIFALPTIDKNAVGYFRRKGYRVYSMVHRVGKTVVAQQNWTTFDARRDIQAALKKIREKHGIKDKPDGSGPSHMTYVVAHCAGSVALASGLLDGTIPRQWLSGVTASQVFMNPKFAKVNKIKASMPISMANIYSLAQGKWFDCTSTPRDGYVQQAINQVLRFYPVGHRHEICNSVVCHRSSLVFGRLWSHKGLNEATHSQLENFVGGTSMASLNHLMFQGTHDYATDSQNENLVTPQNIARLKGLPIFLFSGADNDVYAPDNTDISFTTLSEANGGGFYERQVFKGRGHLDAWMSPTAHKDVFPRVLHHIENVQRGKYDALRKVIAKPEGLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMQ5</accession>
    <name>A0A1B7YMQ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161705.1">
        <property type="nucleotide sequence ID" value="XM_018296889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMQ5"/>
    <dbReference type="GeneID" id="28860996"/>
    <dbReference type="KEGG" id="chig:CH63R_01914"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01914"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="380" mass="42446" checksum="74078E1E74784163" modified="2016-11-02" version="1">MDGVPWEDLPHDDYGPGLLATVWTLAAVAGAFIGLRVYCKFSRGRGLWLDDHVLFASWCAMLALCAFITVDVSYDFGKHNWDITPGNWSWLLLYANLAGSLSIIAAAWSKTSFALTLLRIAQESPERWMKRLVWFIIVSINVALGLSVLFTWIQCWPVEKTWRTASTPGTCWPKSVVMGYNVFTAAYSGAMDIVLAVLPWRIIWGLTMTKREKLGVLIAMSMGVFAGAVSFIKIRTIAAIGAFDIIDTVELVIWGAAESAVTIIAATIPILRALFRDNRPAPARFATDEESMIRRLGAVTVAAPVARGSRSDLELVEWKHTTPLEHKGERSLDSRYRIWRARGTVKKPRRMEPTTPPDVFKGRHGDPEYSGSMELSRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN20</accession>
    <name>A0A1B7YN20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_02173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161964.1">
        <property type="nucleotide sequence ID" value="XM_018297148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN20"/>
    <dbReference type="GeneID" id="28861255"/>
    <dbReference type="KEGG" id="chig:CH63R_02173"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02173"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="525" mass="59994" checksum="71F623C497A2E3E1" modified="2016-11-02" version="1">MSPLGRSIVDPYLAAGVAILVALVLAALRRPKHPRLPPGTTLPPGPEPRPLIGNLLSIPPAHSWLAFHELIKQHGPVVRLSLPGGQEHVLLGTETAANDLLRRRGNLYSDRHHAPAASHLLTDDHMLLLLPYDDKWRRYRRFLHQVTMAPVAPRYETEQRIEAVRLLRDLLRDPADYESLFERFSVGLGLRIIYGLRLESARDRDARMILDIVHELERVGSPGAYAVDLFPCLLRLPERLAPWKRYLRGRRRRDEAFFRELVDRSGSPSWARTWLGTRDEWDLTRREADWMLGSVFQAAATTSGSALASFVLCMVRNPGWFGKLQREVDAVVGAGRLPALEDMPRLPLVRACVKETLRYYPITAGGFPHRLTEDDTYGAYFLSKGTVVHAVQWAIQRDPELYPDPELFNPDRWLDPRYPTFREPLSVYPNLQQFSAFGHGRRICQGINIAERSLNLKVALLAWGCDISRAKDGRGRDVVPPLYDFVEGFNVQPKRFQFDLQPRSRERVDLIERAYEQTLKEDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP16</accession>
    <name>A0A1B7YP16_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162313.1">
        <property type="nucleotide sequence ID" value="XM_018297497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP16"/>
    <dbReference type="GeneID" id="28861604"/>
    <dbReference type="KEGG" id="chig:CH63R_02522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02522"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="52"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="59751" checksum="78812EB79605BFB1" modified="2016-11-02" version="1">MSSQPAVVDDEKNSAKEPAVNSHHGSYEGSRDEETGVVAKGQPLQRNLQNRHMQMIAIGGAIGAGLFVGSGGALRTGGPAALVIGYMIVGIMLMFTTQALAEMAVLYPVNGAFYTYVCRFVDPSWGFAMGWDYAIAWLTVLPFELVAASITIKFWRDDLNMGIWVAVFLIILAIIQIFGVRGYGEVEFVLSIIKIAACTGFIILGIVINCGGVGDKGYLGAKYWHDPGAFQNGFNGFAGVFVVAAFAFGGTELVGLAAAESANPRKAIPMASKQVFWRIAFFYIVNLFILGLIVPSNDPRLMGSSGANTKASPFVLAIQDAGINVLPSIFNAVITIAVISVANSCTFGSTRTMQAMAERGMAPRFLAYVDKHGRPIWCVLIQIAFGLLAFIGESADSSTVFGWLLALSGLSYFFVWGSICLSHIRMRMAWKVQGYTLEQIPYKVPLGIWGSVIGLFLNVICLIATFYNALYPSPNAQPEAEAFFTAYLAAPIVIFLYLLWKVISRDWRLYVPLREIDLKSGVVLADPSDEPLPEKTWANLPRRMARALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPM9</accession>
    <name>A0A1B7YPM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162365.1">
        <property type="nucleotide sequence ID" value="XM_018297549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPM9"/>
    <dbReference type="GeneID" id="28861656"/>
    <dbReference type="KEGG" id="chig:CH63R_02574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02574"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="206"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="634" mass="68774" checksum="F14CCCCB512B7B7E" modified="2016-11-02" version="1">MRPLPGSTAFPGTPSSSDGASDCLASASQSTAAHMSFILTDEATIDSSLAPQYLPLRTRDQRKHAIHTVPGDISAPNRELGTASPATASRSTPTLQPRDSTPPRSVPATNTSPARVHTPPPIASQPMTPILYGVSGPCSAISSSSSRRNSLVGSLSEYQESFVMSAFGSSEPGQPQSSYVGEGAQQFIMPTINVPSRRPFTETGKSLGRLKLLMAGRSGLLPGNALPSDPPIGQGTFQITETFASTKPYPPWWKGSVQGSFMSSSTSTDDTILDRNVCLVDTPGYQETCRVSQYVESHLQKNRLNGLEDSDVLKTIGGSGGLLVDAVLYTIPSSGLTSTDFQYIRQLESLTNVLPLVAHADVLTSEQITESKERIAKQLTEAGIRLFTFAPPASNRDEPDIYAISSKLGLDLDVMDASLLMGSEYVQPLVPTDLSRLLESIFSVDGATWLRHAAATKLLSWRLRHPRTSISSTGLTLHPEGHVDRRLLRTQTGSLTPLATSLVPRYAHHEERFCRIQFTDWAADLQRSLANERVVQERTARAQAATWMGEALRGGLGDEANEAMALTRTRGRRDHQRPFNRRHSTGSTQNWALARHQDPLGLLQLKADFRWQGWNTLEMVGGLGLLGGLAWLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQA4</accession>
    <name>A0A1B7YQA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162641.1">
        <property type="nucleotide sequence ID" value="XM_018297825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQA4"/>
    <dbReference type="GeneID" id="28861932"/>
    <dbReference type="KEGG" id="chig:CH63R_02850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02850"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="20398" checksum="B2DE091BFDABD92A" modified="2016-11-02" version="1">MEKAPDVSAKASGTSVQISRQPDTPKGRRRNRAGDKRKDVPHRPRRQRLEAGGGLGTSRVPPMSGTGSGRRFRAPSQSTPQVRERPWEDSGSANFKGPANTLAGERRWGGGARRIRRADLMLFKSLAEDHAATHKLHAAQLLEVACQCLPRRSKEGDFHFWPASLSDDKHGVSRSSGGLEPGLASFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQG8</accession>
    <name>A0A1B7YQG8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162798.1">
        <property type="nucleotide sequence ID" value="XM_018297982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQG8"/>
    <dbReference type="GeneID" id="28862089"/>
    <dbReference type="KEGG" id="chig:CH63R_03007"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03007"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="120" mass="13672" checksum="4CF08897BADF4223" modified="2016-11-02" version="1">MSESSREAHNTEASGSNNDDSDGLSSKKRKATKKLGRPPKRAKKDDSTSTNTKTRKRTAKGIWEQMDNLWTENDIPSAVRDFLNKMYPLKTLRQLDEIIPKNVTYDEDWSAQDEQNLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSH1</accession>
    <name>A0A1B7YSH1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic-type endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163429.1">
        <property type="nucleotide sequence ID" value="XM_018295067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSH1"/>
    <dbReference type="GeneID" id="28859174"/>
    <dbReference type="KEGG" id="chig:CH63R_00092"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00092"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601881" evidence="3">
        <location>
            <begin position="20"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="28"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="592" mass="63492" checksum="9B3D6DDBFF55B512" modified="2016-11-02" version="1">MAARRVLLLAAAAVAGAGAQLQLPWTTDVGNTTFGPDGPWQAVLVKLNGTGSQMQEVPLWPGGSGVSEIPTADNGGAYNMPSSAVRTGRSRAASDKWFSTVFMESEWSGFEYWDGMELEPRFGSGTQITANATFVAATKWTGSAPLNETDYRPSVGILGFAPRSERSDDTTVPSILEQLKASGDIDRNAFSVHVGSAALGLPGSLVLGGYERNRALGQVGTFTLTDSIPIMYLRDVVLDVEVGTSTSYAEGGNGSFWQESTETGEQYTKYVGGAPGSVVVIPNPASPYIYLPPGFCEAIATSLHMTRHDATGLYLWERSTQAELFVNSSSYLGFVLSDQSATNLTIKVPFTLLNLTLEPPLAERPVSYFPCKSMESPYGFWQLGRAFLQAAFLAIDYEGEVAYMAQAPGPHLEQSVVKKLDGSAVETNPAESFAKTWQDHWQPVYMDRSSFDASDDERLSAGGKAGVAVAGVAVTALFVSGLWFWWRRKRGKGQETDAGSGSQAGSSGESFMDHGAEQKMLRVDKATELDGHTHAVELDPRTPPVEMGAPLPHEMGSHTESTRTVRHEVPSDSVVYELPTPTATPDRAAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSN5</accession>
    <name>A0A1B7YSN5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Archaeal flagellin n-terminal-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_00221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163558.1">
        <property type="nucleotide sequence ID" value="XM_018295196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSN5"/>
    <dbReference type="GeneID" id="28859303"/>
    <dbReference type="KEGG" id="chig:CH63R_00221"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00221"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR15041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="324" mass="36400" checksum="04E1A3BB868F46F3" modified="2016-11-02" version="1">MRGISAEALIAVEWLFITIALCLIIARINLRIFHLKAGFVLSDAFIAAAFAAGVSLNAVDITLYLRGVYEPDIDFKMTNWVATEAESVYVYRTLYFLYFPFYFEQYFNKGTLLALYYEIFGRGSTKIRASLLCLVAYCAAGFITTMCMILFYCKWGCYWYSLSPYSLRVSLALRCWVVNDNLGWALHFSSDVFIFILPLVYISKLNMSKAQKISASVTFSIGLVNILITLSRWFIVQAVFTEVPALNTGQLLAVLDGHIGLIVSILPSLRPYLRLWQNVNDSRPAKSNATSEGLTTGKEETLSTSRVTSSSHDSNKKAEEVSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YX22</accession>
    <name>A0A1B7YX22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165088.1">
        <property type="nucleotide sequence ID" value="XM_018296726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YX22"/>
    <dbReference type="GeneID" id="28860833"/>
    <dbReference type="KEGG" id="chig:CH63R_01751"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01751"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR16571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="131" mass="13581" checksum="F397088F5363AC5E" modified="2016-11-02" version="1">MQEGRRLGDYVSNLLKTSLHLRGLDIGNHPDLVAVSASLGAGPIAPHEGTVDVVQRAYSLAAGDVGDGLVLGFLVRLQFILGLELLVALHRGADTPLVSLGAAPAVFGLRLEGGLNEVAGAVQLGRARLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW84</accession>
    <name>H1UW84_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp70 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04655</name>
        <name evidence="4" type="ORF">CH63R_12175</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000362">
        <property type="protein sequence ID" value="CCF32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153990.1">
        <property type="nucleotide sequence ID" value="XM_018307149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW84"/>
    <dbReference type="STRING" id="759273.H1UW84"/>
    <dbReference type="GeneID" id="28871256"/>
    <dbReference type="KEGG" id="chig:CH63R_12175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12175"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="606" mass="68729" checksum="507A0F272319E31B" modified="2012-03-21" version="1">MYGHTLPDRTGPGLGSISLFDDEGSEKFVAVGIDFGTTYSGVSWARSTRPKELNEITGWSSEDPRNRRETQVPTLYDIDTGKWGYEITPDMVPMRWFKLLLLNDDDIQKEDIRNSPQLQQARQLLAQSTKRKRPVEIVGAYLEKIWNHTYATLKTMMDIEDLPLRVAITIPAIWPAYAQGLMREAAKIAGITKKRDIGETTLILVQEPEAAALASLFQHSSFPEIQKNESFIVCDAGGGTVDVISYKVTSERPFKLEECVPGDGKLAGAFQIDQAFEAHLRGKSKLKITSLSASDYNQFIQKEWELGAKRTFNNTSEPRFFNLHPPSKAYGTMARLRHKETLAINKEEMKGFFSRSLTGIRSLVNSQYKQIEKATGKPPKKILLVGGLGSSEYVYDVLNDLFDNRVLRPSDSWSAVARGAILRLLQENISLQTTLSPKQRVALAVLPNVVSRRSRNHYGIMVDTPVETVDLEPEDEPYKDPEGVNRVTRMEWYLKKGDKVDKASRIPITYHGFYQAPLPPKCTFDIMYSSEDVVPKRPGPKVMDLCRIECDWDKPIEEWKTVGNPYTGWRKHEDLELTMGLEGEPKWEIRVGSKRAEHNFEVQYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWC2</accession>
    <name>H1UWC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04689</name>
        <name evidence="8" type="ORF">CH63R_02650</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000375">
        <property type="protein sequence ID" value="CCF32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162441.1">
        <property type="nucleotide sequence ID" value="XM_018297625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWC2"/>
    <dbReference type="STRING" id="759273.H1UWC2"/>
    <dbReference type="GeneID" id="28861732"/>
    <dbReference type="KEGG" id="chig:CH63R_02650"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02650"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_1"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="483"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="63369" checksum="75A6ACAB9444EE85" modified="2012-03-21" version="1">MSSPPSRLKNILGHLLSSSTPKKDEPQPTHNVHQLSPTFFLERAAAIEPDAEAIFHITANGRTLRRSYIEFADRARGLAYYLKKHGFKRVGILAPNTPAFLESIFGIAAAGGVNVGVNYRLKPDDITYIFDFAEVDSIIVDHEFISLLDDFRAKHPNVPLIVDTDTDATEGQLSGPFDDAVLEGLRYDGLHGKGWAGLHSQCDNEDDMLAIPFTSGTTSRPKGVVYTHRGAYLAAVGNVIESGLNYHTGRCKYLWTLPMFHAVGWTFPWAVTAVRGTHVCLRKIDYPLIWKLLKEEGVTHFNAAPTVNTLLCSAKEAEKLPHEVRVTVAASPPSAHLFEQMTNLNLFPVHVYGLTETYGPITKGYHMPSWETLPASEKYAKMARQGHGFVTSLPIRIVKTDQPEGVLVDVAKDGKEIGEIVFLGNICAKGYYKDAEATKKLFDRGALHSGDLAVHHPDGSAQILDRAKDIIISGGENISSVALEGMLIQHPDLMEAAVVAVPDSHWGERPKAYVTIKEGKSLEGEDLIAWARNQSNISKFMVPREVEVVDELPKTSTGKLKKNVLREWARGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWE0</accession>
    <name>H1UWE0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Microfibril-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04709</name>
        <name evidence="9" type="ORF">CH63R_04076</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000379">
        <property type="protein sequence ID" value="CCF32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160297.1">
        <property type="nucleotide sequence ID" value="XM_018299051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWE0"/>
    <dbReference type="GeneID" id="28863158"/>
    <dbReference type="KEGG" id="chig:CH63R_04076"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04076"/>
    <dbReference type="eggNOG" id="ENOG502SC3P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085138_0_0_1"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="185" mass="20633" checksum="E02EA1A176FDFA20" modified="2012-03-21" version="1">MAKPGVSKKTKQPSVHSRAARRATDVDIDTDKSLKNVKAPVESKDYRPSVLAAQTNAGVSKKSKNRKAQVSAKAKKRNEKAMDRAEAIMERTSNKIEKSKSRSRRIQTRSKQWDDINKDLPVVKKFPDEEDLEVEERKTRAAVVVADKDWETDEEMNGVDEDSTAAVAEAVQAAPANDDIDEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>H1UX23</accession>
    <name>H1UX23_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_04900</name>
        <name evidence="12" type="ORF">CH63R_09336</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000452">
        <property type="protein sequence ID" value="CCF32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156333.1">
        <property type="nucleotide sequence ID" value="XM_018304310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX23"/>
    <dbReference type="STRING" id="759273.H1UX23"/>
    <dbReference type="GeneID" id="28868417"/>
    <dbReference type="KEGG" id="chig:CH63R_09336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09336"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003554221" evidence="9">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="219" mass="25012" checksum="40B4D3160695BCFA" modified="2012-03-21" version="1">MRPFIPLLSLSAVAQALYFYIDGTSPKCFFEELPKDTLVVGHYTAEEWDDRINQWAKHDGLSIYISVDETFDNDHRVVSQRGQASGRFTFTAADAGDHMICFTPSSTSGRAGWLSLHSHNGGIRLTLDLAIGESSEIESSDKNKLEDIATRVKDLNARLQDIRREQVFQREREAEFRDQSESTNARVIRWMLIQLVVLAVTCTWQLSHLRSFFIKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYD0</accession>
    <name>H1UYD0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05257</name>
        <name evidence="3" type="ORF">CH63R_07033</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000600">
        <property type="protein sequence ID" value="CCF32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156786.1">
        <property type="nucleotide sequence ID" value="XM_018302008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYD0"/>
    <dbReference type="STRING" id="759273.H1UYD0"/>
    <dbReference type="GeneID" id="28866115"/>
    <dbReference type="KEGG" id="chig:CH63R_07033"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07033"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_2_0_1"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="335" mass="37424" checksum="AB447FE3C89DF338" modified="2012-03-21" version="1">MAYDQRAKRRKTDDEGYVDTTRMSSKFQPYEGGRAWTVSVAIPSSILTDAITAERRTAVAGRIARALAVFSVDEIVLFDDSPVESRPKNVDTKAYTGDVDGCHFLEHLLGYLEVPPFMRKMLFPLHANLRLANQLPALEMPHHPNPADWLPYREGVASKGVPQGTMIDVGLKNHVLIEDEVPPNTRVTLSYPDYNTDKAEACDPSAPREEGGYYWGYQVRRANSLSSVFTECKYEGGYDVSIGTSERGRSLSDAFPSAAPLDFKHLLIVFGGPRGIEYAALNDKELEGMEMTPAKARELFDHWVDVLPGQGSRTIRTDEAIWVALTSLRRLWVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYH9</accession>
    <name>H1UYH9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetratricopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_05300</name>
        <name evidence="11" type="ORF">CH63R_01986</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000617">
        <property type="protein sequence ID" value="CCF33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161777.1">
        <property type="nucleotide sequence ID" value="XM_018296961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYH9"/>
    <dbReference type="STRING" id="759273.H1UYH9"/>
    <dbReference type="GeneID" id="28861068"/>
    <dbReference type="KEGG" id="chig:CH63R_01986"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01986"/>
    <dbReference type="eggNOG" id="KOG4225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020375_0_0_1"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000246">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="432"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="522" mass="59115" checksum="103BAFD440CC93AD" modified="2012-03-21" version="1">MSLKQEIETWVSALGRYDNNEFDEALKDFERISDTSKILFNMGVIHATLGEHEKAVECYQRAIKLDQYLAVAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNTMIDYAQLGLLFKLYSCEVLFNRGLCYIYLQQKDAGLQDLSYAVKEKVVEDHNVIDEAIREEAEGYTVFSIPVGVVYRPNEAKVRNLKTKDYLGKARLVAASDRANAFTGFAGSEIKNAGKNDVKDDRPADNISFAATNLVKPGLASRRQQSEPPNGRGVFPPTPPPDQLEANNGGTLSRGQSVRNGPKPMLAKLNIENSRPNERYQKTSSPNDRRGPPPVMRSESRSATPSRGYSRRDLQMRGRPVDEEAEDAYPDELYDMYQGSNGNSTRTSRQTSRRVPQRYMDEEDDGSDYGSFDEGDFEMVSNRRPGTNSMSSRGGSRRPEVRKIRVKVHAEDVRYIMVGAAVEFPDFADRIREKFGLRRRFKIKIRDEDVPNGDMITMGDQDDLDMAIMSVKSQARKARQDIGKMEIWVQEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYN8</accession>
    <name>H1UYN8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05346</name>
        <name evidence="10" type="ORF">CH63R_06652</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000636">
        <property type="protein sequence ID" value="CCF33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159477.1">
        <property type="nucleotide sequence ID" value="XM_018301627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYN8"/>
    <dbReference type="STRING" id="759273.H1UYN8"/>
    <dbReference type="GeneID" id="28865734"/>
    <dbReference type="KEGG" id="chig:CH63R_06652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06652"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="37"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="609"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="696" mass="77027" checksum="CB2C41901DFFBEDB" modified="2012-03-21" version="1">MSAPQSLSSQGGISDPALITLVNKLQDVFTTVGVTNPIDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGICTRRPLVLQLINRPATSQNGIEEVENSTDKAANADEWGEFLHIPGQKFYDFNKIRDEISRETEAKVGRNAGISPAPINLRVYSPNVLTLTLVDLPGLTRVPVGDQPRDIERQIRDMILKYISKSNAIILAVTAANIDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIDNKKPIQAALENEKNFFDNHKAYRNKSSYCGTPYLARKLNLILMMHIKQTLPDIKARISSSLQKYSAELESLGPSMLGNSANIVLNIITEFTNEWRTVLDGNNTELSSTELSGGARISFVFHELYSNGVKAVDPFDVVKDVDIRTILYNSSGSSPALFVGTTAFELIVKQQIKRLEDPSLKCVSLVYDELVRILSQLLGKTLYRRYPSLKEKVHTVVINFFKKAMEPTNKLVKDLVAMEACYINTGHPDFLNGHRAMAMVNERYNPSKPVQVDPKTGKPLPGGTPRASSPVVPEDSANGGFFGSFFAAKNKKKAAAMEAPPPTLKASGTLSERENIEVEVIKLLISSYYNIVKRTMIDMVPKAIMLTLVQFTKDEMQKELLENMYRTDTLDDLLKESDFTIRRRKECQQMVESLGKASEIVSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYS4</accession>
    <name>H1UYS4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_05377</name>
        <name evidence="5" type="ORF">CH63R_01425</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
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                <person name="Will I."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
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                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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    </evidence>
    <sequence length="301" mass="33067" checksum="DCFF314D8A659A0A" modified="2012-03-21" version="1">MSAPIKTVALAGANGFLGKVLLQVLLQSGRFQLTVLTRKGSRHEFPAGVAVKKVDYESVPSLEDALRGQDALVSALAFDAIHIQKNVVDAAFNAGVRRMIPSEYGNDTKNPKLASIPIYQPKIAIRKYLDEKVAERPSFSYTIIMNVSFLAPGYALDFLVDVRGKKAHIKDGGDVKFNATTMPHIGQAVIGILTHLDETANRPVKISSVETTQNEIVEIAKAVDPSGEWEMTHSRTEDLERIAHERWNAGDHSEEVVEMFINRAFIGTEAGYFPETDNKLLGIESIGREGLEKIIRTAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZ19</accession>
    <name>H1UZ19_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hsp70 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_00938</name>
        <name evidence="2" type="ORF">CH63R_00270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000679">
        <property type="protein sequence ID" value="CCF33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163607.1">
        <property type="nucleotide sequence ID" value="XM_018295245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZ19"/>
    <dbReference type="STRING" id="759273.H1UZ19"/>
    <dbReference type="GeneID" id="28859352"/>
    <dbReference type="KEGG" id="chig:CH63R_00270"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00270"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009958_6_1_1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="611" mass="68386" checksum="7F3AFE8AA13388BA" modified="2012-03-21" version="1">MSGFADGDLSVSPDEHAIIIGIDFGTTFSGVSWAFSGQPNDIEVITRWEAELNYNSDTEKTPSTLFYHGPYGEASWGYGIPAATSAEPLKWFKLLLIDHQDLPRELQSSAQIATARRLMSETNMDPVDVIAGYLRRLWNHSIDCITLSTGKELVKMCKFHVVITLPAIWPVYAKARMTRAAQEAGILENRSAGDTVLSFISEPEAAALATMRDLSNRPNIKPGDHFVVCDAGGGTVDLISYEVTDTKPMVVREAVKGNGGLCGGVFLDEGFVNLMKSKIGSESWASISIENMKKLMNGEWEHGIKQQFDTRPRDWPVTLPSGCIMTGPSRRVMKKETITLNHSDLLPVFETISQQIIKLIQEQIDGIRATSGKLPKYVILVGGFGRCRFLSSRLQLALDDTMELLQSQGTRPWTAICRGAVIQGLTRQNLGIGISVRVSSRIARMSYGVKFYTKFDPKLHRLKDKFWDEIEQEWKAKDQMEWYMKKGDDIADKKPIRHKYHRRYLTAPSEITKELHFSAASPAPKRADSTTKRLCKITWNRKVNFDTLPTFTNSLGRVYHHLVFEIEMISDGTSLDFTIIHDGKRVGSKNVTVEFEPEGGEASGRAVNAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZ27</accession>
    <name>H1UZ27_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_00140</name>
        <name evidence="11" type="ORF">CH63R_06314</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000680">
        <property type="protein sequence ID" value="CCF33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159139.1">
        <property type="nucleotide sequence ID" value="XM_018301289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZ27"/>
    <dbReference type="GeneID" id="28865396"/>
    <dbReference type="KEGG" id="chig:CH63R_06314"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06314"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_1_1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000429">
        <property type="entry name" value="MFS drug efflux transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="564" mass="59807" checksum="1722F111F432ECBF" modified="2012-03-21" version="1">MSPDTTSPDPNGSHPEKHAGAVDSGSQSPPENLNGSTNDASSVEKTNPRNIHGWKWAVAYSAMLSTTFLFALDNTIVANIQPAIINDFGHLELLSWIGTGFALGTMFILLWGKVYGVFNIKWVYIFNIFLFEAGSALCGAAPNMETLIIGRVISGVGGSGMYSGTLTYVSVLSNEQEKPAYLAGSTVIWGVGSVLGPVVGGAFAASSATWRWGFYVSLPVGAAFIPVYFLLFPSVDPHPTKTLAEKFRLVDWVNAVIFLAGSACLTVVLTFGGVVYPFRSGTVIALWTVTGVLLVAFIVMLKMHPLVSKENRLYPVHFFKQPTLINMQLQVFLSSGIILAMTYFIPLYFQFVKGDGALDAGVRLLPLIMFMVVASMVNGFLMPRYGLIPVWYIGGSSLALIGTALMFTVNDTTPNANIYGYNILVGAGTGCYIVAGFAIVQSLVPGYDVANAVGAMTISQDLGMVLFLAISGSLFHNIAVDKVGKALPDVSHTEIGNLIAGSTSSAFQALTDAEKALVIPEIASAMTSIWAFFLAAAALSVVCSLPLLRTKLGGGKNAPAVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZC9</accession>
    <name>H1UZC9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conidiophore development protein hyma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05542</name>
        <name evidence="3" type="ORF">CH63R_12842</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000716">
        <property type="protein sequence ID" value="CCF33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152233.1">
        <property type="nucleotide sequence ID" value="XM_018307816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZC9"/>
    <dbReference type="STRING" id="759273.H1UZC9"/>
    <dbReference type="GeneID" id="28871923"/>
    <dbReference type="KEGG" id="chig:CH63R_12842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12842"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035839">
        <property type="term" value="C:non-growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071574">
        <property type="term" value="P:protein localization to medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="43178" checksum="2A03222FA475610E" modified="2012-03-21" version="1">MSFLFGRARTRPAVDLPKQARDHVTKLEGPSGPAKAEELAKVLNQMKFILQGTQESDSSPEQIYQLVTGLIEEDLLYLLAVNLWRLPFESRKDTQVIFSYVFRFRPPTASPKSDPLALSYVVNNRPQVLLELCRGYEHKESATPAGTVLREVLKSEAAAAIILYDDDDESGSSSKGINLIDRDRRQSGNGVFWRFFDWVDKSSFEVAADAFTTFRELLTKHKELVPRYLSVNFDLFFDKYNNILVQSNSYVTKRQSIKLLGEILLDRSNYSVMTAYVDRGEHLKICMNLLRDDRKMVQYEGFHVFKVFVANPHKSIAVQKILLMNREKLLTFLSHFLEDRTDDEQFIDEREFLIKQIRNMPPNPVAPQRHGMSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZE3</accession>
    <name>H1UZE3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cardiolipin synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05556</name>
        <name evidence="10" type="ORF">CH63R_06940</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02000721">
        <property type="protein sequence ID" value="CCF33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159765.1">
        <property type="nucleotide sequence ID" value="XM_018301915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZE3"/>
    <dbReference type="GeneID" id="28866022"/>
    <dbReference type="KEGG" id="chig:CH63R_06940"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06940"/>
    <dbReference type="eggNOG" id="ENOG502SCKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164169_0_0_1"/>
    <dbReference type="OrthoDB" id="5193244at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497536" description="Cardiolipin synthase N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Cardiolipin synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="110" mass="12026" checksum="3C49B6D7251F830E" modified="2012-03-21" version="1">MAQKALVTNFLLQLCFAMLAVAAPASDPAVAATAYDNTWQYGTGGGILGFVVLVLDIIVFIEVLKSDRPVSHKVLWCLVVFLFPIFGMVIYWLFSNRAAHNSRAGYESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZP7</accession>
    <name>H1UZP7_COLHI</name>
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        <submittedName>
            <fullName evidence="3">TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05642</name>
        <name evidence="4" type="ORF">CH63R_12860</name>
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    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000765">
        <property type="protein sequence ID" value="CCF33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152251.1">
        <property type="nucleotide sequence ID" value="XM_018307834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZP7"/>
    <dbReference type="STRING" id="759273.H1UZP7"/>
    <dbReference type="GeneID" id="28871941"/>
    <dbReference type="KEGG" id="chig:CH63R_12860"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12860"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003663_1_0_1"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="659"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="929" mass="102753" checksum="90D7772AFD36A7FA" modified="2012-03-21" version="1">MAPQKFASMRLKSRPTLVPFKDETSLIALRYEKTVQAEPPIPILTRASPRSSSVSTHRTSTSASSSLSCPPPSPVVVTPPPTIDQHPAFRSRTPACNTTANDWKRDSGLAPTSSSSATIAEECEDGEHTYEKIVAPNPNIAVVQQSEERVIPFVCDNDSLNSAAEWSLSKQRQPGRCTPSTGKQSDIMDHHHVAQVEIAQRKAPDSLSSTLSVGSPVALRNKRLSDLSPAAAQMITQTSVSSLTTSDNSPNLSPVDIPDTLDLLSKDSVNFSPISISIPTDNLIDDDFLKTLSFSNRGSLMFGGRRPFPTQTTDETMADKSRTDEAHAPAPAPADAPATAATPILHIHYEERPQSTAASTTDACANDMSATQTPTTEATTAEATADSASQAAMTTPSIRVLSEDVELESRKVRSLYESGEGLRWEDGGRPSDVGDRLEATVEIPTDDLENDPVAELQPPAWGTPRSGSSYSQRPETRSEYEVAGGLEDWEDVEGQDVDRYGFINPRKPESRGGTPTELKSSQYAPRKKNGLSKRDVFGLGLPSRGPSRKVSARSLNTQTSRASAASRRSARSVVRQAGNLLPHNQERRWMDIAGGMLSLSLGDEESVEKISEAIKKKEWERSEKWRKMARVIKKGKDGEGMEFEFDVKNQKLIDRTWKGIPDRWRASAWYSFMATHARSHKNSPSEDSIITDFHRLQCRGSPDDVQIDLDVPRTISRHVMFRKRYKGGQRLLFRVLHALSLYFPYTGYVQGMASLAATLLCYFDEEKCFVMLVRLWQLRGLEKLYSPGFDGLMAALNDMQTKWLDGKDVAKKLAELCIDPTAYGTRWYLTLFNLSIPFAAQLRVWDVFLLLGENPSDSPKVSSSSTTMDGIDILHATSAALIHALREVLLDSDFENAMKALTSWIPVKDEDILMRVTRAEWKSRQKKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0Q6</accession>
    <name>H1V0Q6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_00154</name>
        <name evidence="16" type="ORF">CH63R_06964</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="CACQ02000902">
        <property type="protein sequence ID" value="CCF33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156717.1">
        <property type="nucleotide sequence ID" value="XM_018301939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0Q6"/>
    <dbReference type="STRING" id="759273.H1V0Q6"/>
    <dbReference type="GeneID" id="28866046"/>
    <dbReference type="KEGG" id="chig:CH63R_06964"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06964"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF13">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="39401" checksum="C90466E50F91D977" modified="2012-03-21" version="1">MSNTTTTEVLTRKPGNVAVYTNPQHELYLKQVDLPTPGVGDCLIHVRATGICGSDVHFWKAGHIGEMVVTGENGLGHESAGVVIAIGENVTKFKIGDRVALECGIPCMKASCFFCRTGKYNACPDVVFYSTPPHHGTLTRYHVHPEDWLHKIPDNISYEEGSLLEPLSVALTGIERSGVRLGDPVVICGSGPIGIVTLLAANAAGANPIVITDINETRLQMAKKAVPRVRTVLVTPGKEPHAVAEDVKDALGQEAKVVMECTGVESSVITGIYSCRFGGMVFVIGCGKDFATIPLMYMAGKEIDLRFQFRYRDIYPRAIGLVAERIIDLKLLVTHRFTLEEGEEAFKIASDPSGLALKVQVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0U6</accession>
    <name>H1V0U6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05951</name>
        <name evidence="10" type="ORF">CH63R_03184</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000916">
        <property type="protein sequence ID" value="CCF33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162975.1">
        <property type="nucleotide sequence ID" value="XM_018298159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0U6"/>
    <dbReference type="GeneID" id="28862266"/>
    <dbReference type="KEGG" id="chig:CH63R_03184"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03184"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="545" mass="60568" checksum="F084DE6D61657EDB" modified="2012-03-21" version="1">MASQAPATNQTGGRTADVIEPVQETQPTPANPLQEKAAQFLAAHGGGDTTFTYEEEKAVLKRINLRVLPLILGAYFFQQLDKSSLSYVSIFGFQEDANLHGRQYSWLGSILYIAQLVWQPAAAFILVKLPNGKVIAAAIFLWGSSLAIMTACTNFGALLGLRFLLGTFEAMIAPSCLAVTTTWWRRSEQTLVTSSWNAMNGVTFIVGSLFTYGLGHIESDKLFKYQIIFLFCGLLTVTYSIVVLVFMPDSPMSAKYLTEREKVIAVERLRANQMGIQSGIWRWDHVWETFMDLKTWCWFVLVVAISIASGGISTFGNLIVKSFGYNSFQTILFNIPFGVIQIVAIMGSGWIATRTQRKGLVIAGIAVIPAIGTILMLTIPRQHKGVLLFGYYLVSTLAAITPLIYTWQAQNTAGDTKKKTTSAVVFIGMCTGNIIGPLLYSVDDAPVYRPGLISNLVMFILVAFMGALIPLYLKYLNVQHAKRREALGKSTQIVDESMMRNKDVQDSKAVELEEDPQRHQHRTIEEDHGLQDMTDLKNEDFIFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2F3</accession>
    <name>H1V2F3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06407</name>
        <name evidence="3" type="ORF">CH63R_01595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
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                <person name="Heiman D."/>
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                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <strain evidence="5">IMI 349063</strain>
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    <sequence length="313" mass="33585" checksum="8A9F7CEA939B700B" modified="2012-03-21" version="1">MPMNKKNPERKTYFILRSTDYKPDGLIQLGQLIEDPHTPYRRIAPPIRPLPADAVHVSLKNDWSLDKSKGAAGELGVFAQFLAVITAEASAHASNEFTQSWSAAQLETAFLELGSDKESDYVTSSVQKAAVQKRLTREGFFKKMVLSKKVLYMVTGVKIARRPGQVSSGATKTTGGAVKLGADPGTGGVVTTGVQGGLDRSSSFVESSTPDDDFVFAYRLRKVHVNFSSNTSLLGNDVSGAELHGHGAGGGGSDTSSDEESDEEVPEEVVVDVDEIDKVLVEKEDFGDSLPARDEKNDGLDEFDSGECLVIVA</sequence>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Sisk P."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
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        <property type="nucleotide sequence ID" value="XM_018296086.1"/>
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    <dbReference type="STRING" id="759273.H1V301"/>
    <dbReference type="GeneID" id="28860193"/>
    <dbReference type="KEGG" id="chig:CH63R_01111"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01111"/>
    <dbReference type="eggNOG" id="KOG2867">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
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    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
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    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
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        <property type="entry name" value="PTPA_C_lid"/>
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    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="361"/>
            <end position="374"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15931.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3P1</accession>
    <name>H1V3P1_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06755</name>
        <name evidence="3" type="ORF">CH63R_06491</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001295">
        <property type="protein sequence ID" value="CCF34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159316.1">
        <property type="nucleotide sequence ID" value="XM_018301466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3P1"/>
    <dbReference type="GeneID" id="28865573"/>
    <dbReference type="KEGG" id="chig:CH63R_06491"/>
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    <dbReference type="eggNOG" id="ENOG502R30X">
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        <property type="component" value="Chromosome 4"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <begin position="22"/>
            <end position="88"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        <source>
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            <taxon>Glomerellaceae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001416">
        <property type="protein sequence ID" value="CCF35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154774.1">
        <property type="nucleotide sequence ID" value="XM_018305350.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759273.H1V4I7"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10376"/>
    <dbReference type="eggNOG" id="KOG2844">
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    <dbReference type="HOGENOM" id="CLU_007884_8_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
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        <location>
            <begin position="7"/>
            <end position="25"/>
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        <location>
            <begin position="8"/>
            <end position="355"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF35139.1"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="402" mass="42899" checksum="868D1370CA3E0746" modified="2012-03-21" version="1">MSESPESVTIVGAGIVGSALAYFLSASPTSRRITIVDRSFSPLLGSTGHAPGFVGQFNESDVLTKLAIETVSEYTKIPGGFDTVGGLEIAFGPAGVERLKSRCANAARLGLPAKILSIEEAHALAPELVKASSSGAAAFFPTDGTASACEITSFYQEGAKKSGVQFLQSEVRKLVIWDGRVAGVEVSDGDCVRQLDAGKVIITTGIWAQDLCRDLGFPVPVVPVGHPYMHGQLRAPLSRKLPFVRWPEHHVYARDHGERYGIGSYDHAPLECKAKNDTAIGSWVKDFEQTLQSATALLPSAAAEQFDQGASFNGIFSMTPDNMPLAGSVQSLPGLHMAVAVWVTHAAGTAKYLTQVIDGKDVDQETRSALDPERFRGQDLATLEEKSLLGYNSIYKTVSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1V4K3</accession>
    <name>H1V4K3_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Immunoglobulin I-set domain-containing protein</fullName>
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        <name evidence="4" type="ORF">CH063_01256</name>
        <name evidence="5" type="ORF">CH63R_05374</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001424">
        <property type="protein sequence ID" value="CCF35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158199.1">
        <property type="nucleotide sequence ID" value="XM_018300349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4K3"/>
    <dbReference type="STRING" id="759273.H1V4K3"/>
    <dbReference type="GeneID" id="28864456"/>
    <dbReference type="KEGG" id="chig:CH63R_05374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05374"/>
    <dbReference type="eggNOG" id="ENOG502QTU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004852_1_0_1"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556207" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="856"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120400" checksum="BC1CA1B980AF8BD9" modified="2012-03-21" version="1">MAFVNLKSISLVAISSLAPLISALGQKQVISFESAQDSFQLAGGDVGTGQILVSSDDYWGVIRAAGDLALDFGRVTGTTYTLSNGVNGSEPASYTFSPVDVSNNTIYRVQDEQSFRGPNYTDPVPGSTVIIAGTIGHSKFIDDLIAAQKLNTSEVEGQWESFVSQLVEEPVPGCSRALVIAGSDPRGTIYGIYDISEQIGVSPWYFWADVPPKKATDIYVLPEGKVQGSPSVKYRGFFLNDEQPGLSSWVSTQWNDTWNDSAGYNYHFYSLVGELLLRLRANYLWPTLWGSIFYVDDPLNQPLLDAYEVVLGGSHTEPLMRAQNEFRTYYQGQWAYNLNNETIDDYFRYGVQRAKPYARNSLWTMAMRGTGDTAIEGNLGVEAIVEMLEELVENQRRIIAEGLEIESASEVPSLWCLYKEVQSYQEKGLHVPEDITLLWADDNWGNVRRLPLVNETDRSGGAGVYYHFDYVGDPRDYKWINTIQLEKTAEQMYLAYARNARRIWIVNVGDLKPLEIPISHFFDLAYDTEKWGVDGTGEWLGSWATREFGDEHASNISEILTKYGMYAARRKYELVEPHTYSVINYNEADAVLEQWAALHKQAQAVYDALDEEYRAAFFEMILHPITAGEILHKIQINGAKNQLYAGQKRNLANDVIDESRALLDADAELTVRWNELLDGKWLHMLDQTHLGYDGYWQQPMRNTLPDMRYVQTQFPSLGGQIGVGVEGSNASVQGDDKWHTNSANDLAVPPLDPYGALTRYFEVFTRGNKACPWEASPWQPWVKLSQYNGTVGGDNGTDSRVWITVDWENAPAAPNATQVYINVTTPCRDKEKYAGQGQRVIVPVVNREVPSNFTEGFVESDGHVSIEGPHYQKIVEPSSSSNSSSSSSSNSKKLEYHVLENYGRTLGGVGLYPAESEKVKLGEGPALEYSLYLFTNTSKANVTLYISPSANYLGDGNPLEYGISLYPTGDDEPQPKTVQPVGRTQGQNMPEGWGYAVGDAVWGLNGNYTTTTFNVTQEGAYTLRVWALLPNIIVQKIVVNLGGVRKSYLGPPESFLLGRDDKGVANRTAFTDTPGVLGGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAN7</accession>
    <name>H1VAN7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_08668</name>
        <name evidence="10" type="ORF">CH63R_01237</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002399">
        <property type="protein sequence ID" value="CCF37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164574.1">
        <property type="nucleotide sequence ID" value="XM_018296212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAN7"/>
    <dbReference type="STRING" id="759273.H1VAN7"/>
    <dbReference type="GeneID" id="28860319"/>
    <dbReference type="KEGG" id="chig:CH63R_01237"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01237"/>
    <dbReference type="eggNOG" id="KOG3983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036311_1_1_1"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="38835" checksum="660AFC433FF58685" modified="2012-03-21" version="1">MSAPAGGLTRRRGGGGAAAGDGETSNGAPRTNSTNNFKDSAPETSYESGENGHKIAFDPRDISESAERSKQPKLTLMEEVLLLGLKDKQGYLSFWNDNISYALRGCIVIELAFRGRISMQKDASRRRFPLADRVIEVIDETLTGEVLLDEALKMMKQSEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKEEIRRRVRNVLTQRTVVLPASQFLPENLEFRYVRTIAMVCAAYAANVLENALSTLGHEARERAFAQTDELLADYSQWPFGKKATGNGIGANLPQVIAEEISSGKDKELQLEVVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBK9</accession>
    <name>H1VBK9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08905</name>
        <name evidence="11" type="ORF">CH63R_13203</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02002545">
        <property type="protein sequence ID" value="CCF37612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152594.1">
        <property type="nucleotide sequence ID" value="XM_018308177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBK9"/>
    <dbReference type="STRING" id="759273.H1VBK9"/>
    <dbReference type="GeneID" id="28872284"/>
    <dbReference type="KEGG" id="chig:CH63R_13203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13203"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010969_1_1_1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497633" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="169"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF37612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR04076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="709" mass="76842" checksum="F6AA95E4DF28A453" modified="2012-03-21" version="1">MRFTFILVFLAFKAVADSLPGLPTVPYTPTGGTLPSASLTRIIVSSEFAEFVDNAGQTLIPPTLHSFATTFASDLASVVGLDIPVELGATAEQGSIFLTLGDASLYRDAAGRETSEGYSLNVTVDGVLISGASPLGVWWGTRTLLQQLVLDGGEVKLGYGVDSPGWGIRGMMLDIARHYYPPDFLVEMCAYMSFFKQNTFQLHLSDNLYNNVAIYSRERSLSLYAAFRLLSDDPALEGLNRRANESYTRDVFDDIQARCAARGVTVLPEIEAPGHALVITQWKPELGLQSDLSLLNISNPETIPVVKKIWDTFLPWFHTKTVSIGADEYVDPTLSEEALVGEYTRFVDEMNEHITSTSGKHVRIWGTFAPSVGGSVNKSISIQHWANFEANPLYDFVNNGYDVLNSGEYIYTVGKWSQWYGSTLSLDFIFHGSPDGSAFAPNIFDRENATNNAARDSPSLLGHIAPQWNDYGPNATTVTEGYYQWRDGLPALADKQWGGDVAEADYQGLFAALQPLAPGQNLDRRVASKGSTILEYDFKQGRGSNGTVEDLSGNQYHATSTCAAGDEGAILTPSCRITTPLNQKGRNYTLSFSIKPTSDAKGAIFSGGDSGLWFGNGTVSAVMLFSGESTYALNYTFPVGSWTNVSLIGRGRQTFLDVGAGEPMEFLTVMGWNGDRFVWAPIAVEAPLATVGGSGFEGVIGGMKLVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VC26</accession>
    <name>H1VC26_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_09030</name>
        <name evidence="2" type="ORF">CH63R_07102</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002630">
        <property type="protein sequence ID" value="CCF37779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018302077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VC26"/>
    <dbReference type="STRING" id="759273.H1VC26"/>
    <dbReference type="GeneID" id="28866184"/>
    <dbReference type="KEGG" id="chig:CH63R_07102"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07102"/>
    <dbReference type="eggNOG" id="ENOG502TE0W">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_112102_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF37779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08337.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23902" checksum="4AC9D0A01401B457" modified="2012-03-21" version="1">MSGPATFGGPTRVILDVKGDVPDWKEEYKKFLLSVKDSEGYFRYRWGPWKEDPSKLEILATWAPMETRQAFGKSPHHQRAVDALKPVLAGPTPTKCPRFDLDTTTFVPPPPQLINSPICEVITVRHCTGDPKVMAETLKRAEALPGCYSAHSGVGATDTPDQGTVWIGFVGWRDYESSEEADKSIYMPHGMGELESHHINFNFPIKGFSVTNPGR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VD18</accession>
    <name>H1VD18_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
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    <gene>
        <name evidence="4" type="ORF">CH063_09287</name>
        <name evidence="5" type="ORF">CH63R_11204</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002814">
        <property type="protein sequence ID" value="CCF38121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153019.1">
        <property type="nucleotide sequence ID" value="XM_018306178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VD18"/>
    <dbReference type="STRING" id="759273.H1VD18"/>
    <dbReference type="GeneID" id="28870285"/>
    <dbReference type="KEGG" id="chig:CH63R_11204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11204"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010194_44_0_1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="SDRFAMILY"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="36924" checksum="8A706538F20E00F8" modified="2012-03-21" version="1">MAPAYNQETRASELVPLYAPYIAGKTILVTGVSPGSIGDSFVKQVAVAKPAVFVLAGRSPSKFQRLVNDLATEHPEIKVKSLVLDLASFANVRKAAEEVNTWADVPQIDVLVNNAGIMAGSYKLTEDGFESQFQTNHLGHFLFTNLIMPKVRASASPRIVNVSSSAHRLHHVRWTDYNFNEGKHYEKWMGYGQSKTANSLFSVALAERLGDHTAQNGLTAFSLCPGYVPTNLGAHEAHDFPAFLEDLRKADVLAGSKYMWGLGHIKAKDLDLGVATHVFAAFAPELRENNGEYLTDCHIADPWKEEVFSWARSKVDAEMLWALSEKLVGQEFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>H1VF56_COLHI</name>
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        <submittedName>
            <fullName evidence="2">La domain family protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">CH063_09848</name>
        <name evidence="2" type="ORF">CH63R_11838</name>
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    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003192">
        <property type="protein sequence ID" value="CCF38859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306812.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VF56"/>
    <dbReference type="STRING" id="759273.H1VF56"/>
    <dbReference type="GeneID" id="28870919"/>
    <dbReference type="KEGG" id="chig:CH63R_11838"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11838"/>
    <dbReference type="eggNOG" id="ENOG502T4QR">
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    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF38859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="62" mass="6761" checksum="0606AEE8D6634277" modified="2012-03-21" version="1">MFEEFRACAVADATGKMVSTTGLENLIAYYETVLQGEQEKPLGNIEFLYGQAIELAAKADIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFK9</accession>
    <name>H1VFK9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09958</name>
        <name evidence="3" type="ORF">CH63R_14270</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003265">
        <property type="protein sequence ID" value="CCF39012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151562.1">
        <property type="nucleotide sequence ID" value="XM_018309244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFK9"/>
    <dbReference type="GeneID" id="28873351"/>
    <dbReference type="KEGG" id="chig:CH63R_14270"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14270"/>
    <dbReference type="eggNOG" id="ENOG502SN86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002639_3_2_1"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
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    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="290"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF39012.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">CH63R_10464</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Glomerellaceae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
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        <property type="protein sequence ID" value="CCF41140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR06921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018303416.1"/>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004747">
        <property type="protein sequence ID" value="CCF41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="404" mass="46906" checksum="204DEA5597A65534" modified="2012-03-21" version="1">MIRSVTSLLSSEAWKLLIGLLALFSAALLSRSFSTLRRSKSAPFSNEPSRRSHEKPKKISDSWQMPIPSPYPDWSIDKTKPLPYRAFRYGPKYNVTMGLRSIQPHEWIELDNQFPKFHADKATRIQERGEKCVGTDPEAYPAAMELLEELVQYLPARYPTLFKRTAVGIDNLWSGESFNITESPLKEDPMAIAARLVQDDLAIMIERPDGQYYLLAGAILLAGFWRLGDKFGMSLEEIHTSGDVPHYREKLHTGMASFFRRLRRDQIYSRNNYFIQVDDALPWSWSIGHEDSPVVSWSTAEKDRAVEHHYFRSERQSLRRLPRTGAIVFTIRTYFHPVTELVAEDYVPGRLASAIRSWDETVANYKGREKYETVLLEYLDREHQKQVARGLDLEKEDEVRRYPW</sequence>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004790">
        <property type="protein sequence ID" value="CCF41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018306658.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VMX2"/>
    <dbReference type="GeneID" id="28870765"/>
    <dbReference type="KEGG" id="chig:CH63R_11684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11684"/>
    <dbReference type="eggNOG" id="ENOG502R29D">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 8"/>
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        <location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF41576.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04981.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005013">
        <property type="protein sequence ID" value="CCF41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152046.1">
        <property type="nucleotide sequence ID" value="XM_018307629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNU7"/>
    <dbReference type="STRING" id="759273.H1VNU7"/>
    <dbReference type="GeneID" id="28871736"/>
    <dbReference type="KEGG" id="chig:CH63R_12655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12655"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160285_2_0_1"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="73" mass="8000" checksum="8A87730917A78F14" modified="2012-03-21" version="1">MPADDRSGKQAAAQQAVDILHEISTILNCHLDRRTLSICISMIENGVNPEALATVVKELRKESQEVDAQIASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNU8</accession>
    <name>H1VNU8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Duf1000 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_00413</name>
        <name evidence="6" type="ORF">CH63R_12654</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005013">
        <property type="protein sequence ID" value="CCF41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152045.1">
        <property type="nucleotide sequence ID" value="XM_018307628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNU8"/>
    <dbReference type="STRING" id="759273.H1VNU8"/>
    <dbReference type="GeneID" id="28871735"/>
    <dbReference type="KEGG" id="chig:CH63R_12654"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12654"/>
    <dbReference type="eggNOG" id="ENOG502QRAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005807_1_0_1"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="63"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="559"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="916"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1061" mass="116730" checksum="852920356DE97403" modified="2012-03-21" version="1">MADEREETGRLYGPPRITVVPHEGLEDGPPLLHTSRVPGQGGSEAASFLAEDLTRLMRPEATPTTQPLLAITQMADVTNHTRVVPVPVLAMAAGESGELLRLSKIDEIDWHWGENESPALQIFSIDQHDREESVLWSHDGAPILQIKAALSLVRFEPTRWLLVQKRTSTTILQPEYHKVPVSERPPGIDKAIERPSRINPKPILTITSEQTGGFAHSDVSFSYGSQKKPPQLAIVDECGYYSVWDVKGRDMVGSASMRPKLRHCGHIQLGVTEQLPDEDSPAFRPEPHGVLWIGAAGPGVDLWDVPTVQDPDTGNDLAALTARSKKLLLWNRTKFEVVDMKNPSFRESLSILRPNEPDRILDVKSNPLSQSQLFILTSSNIFWIETSSRGAATAKSDSLAVLQSFSHLRGSDADTLRLTVHHGGHGSGNGTCALYLYSEKSPEVGVYWLSIPEETGLPQFEHHIVRLSDNPPKLQTVWPAPAFLHTTSSAAPKGPGANYMDQQVQFQQLFVLGRDLSLSRSLLAISAVPALEVVPPDKSREWSRDGRRQVHNKRRKQFLQHFEGTFIVPDGLGDMDELVQRRANRYQELMKIEQERNSQQIQQRWPRSQNLDFFMSRITVSIESVIMASEHATIEGPLSIFEAIEEAAANCLETEGGYIPLHTLHEYEPSFEAPPISHEAVVAWDSRFQELLGSQTKRIVAQPIINQYFCRGDRPAPLADIRDQLLELWGPAGLPEGARQSRNVILAETAEAIARSLFGVAILDANLPTEESGPPTWVPEPPPQPTIQQPSQRSSQRFSLSPAKRNQLSSSQRLSLSPTKLSQPFSQRISLSPTKRGQALGQRLSFSPSKGARSQSPYAPSSSIPFPFPSSGTFSQSMDASQADTPPTGAPSPSTALQRLSMLAEDLDITNPPTRQHSVLAYWPTARGASADDYVSSVLASSTKHIDVINERRQRAESRRRKRRSQLLGSSAAATSSQTYGTQDEWEDSGPGTGPESVPPPATQPLPKLAPPVIGSSQVPPVVPSSQVAFSSQVPQVLSQPVSGRHAMRSPGKKKKRKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VP20</accession>
    <name>H1VP20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12096</name>
        <name evidence="4" type="ORF">CH63R_04006</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005066">
        <property type="protein sequence ID" value="CCF41974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160227.1">
        <property type="nucleotide sequence ID" value="XM_018298981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VP20"/>
    <dbReference type="GeneID" id="28863088"/>
    <dbReference type="KEGG" id="chig:CH63R_04006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04006"/>
    <dbReference type="eggNOG" id="ENOG502SG6B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121547_1_0_1"/>
    <dbReference type="OrthoDB" id="5214669at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="163" mass="17459" checksum="9C3912C29E3B2180" modified="2012-03-21" version="1">MAVSQETAAPIALPEKAAYAPLSDNMTSGNLTPVASTPEKSLEMPRESNLSTPRSYRNENPFDTDIEAMITTTSSSDPYAMKSITTTKDCPTIWPGKQDWKAKAKAAKRDRGSCACMARMSKKNRIIMKVAIGLLIIGAGVGVGFGVSKPLGAPIWGDNDKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQD6</accession>
    <name>H1VQD6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">CH063_12441</name>
        <name evidence="11" type="ORF">CH63R_00733</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="CACQ02005387">
        <property type="protein sequence ID" value="CCF42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164070.1">
        <property type="nucleotide sequence ID" value="XM_018295708.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VQD6"/>
    <dbReference type="STRING" id="759273.H1VQD6"/>
    <dbReference type="GeneID" id="28859815"/>
    <dbReference type="KEGG" id="chig:CH63R_00733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00733"/>
    <dbReference type="eggNOG" id="KOG2631">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_4_0_1"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR15553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="253" mass="28206" checksum="36C4A586181126F7" modified="2012-03-21" version="1">MASASEIQNPDQLVTSDDPEHPANLIPSLCAKFWTLGWVTGTGGGCSIRDDDLVYLAPSGVQKELMKAEDIYVLSLAAQESSLKNRIYLRSPPSYKPSQCTPLFLAAFTRRGAGCCIHTHSHWAVLVTLILESRGAGNDKLFEINNIEQIKGFGKGFQKQGNLGYHDTLRIPVIENTAHEEDLTEFLEEAMDKYPDTYAVLVRRHGVYVWGDNVHKAKTQCESLDYLFQLAVEMKQLGIPWISDVPVVKPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQE7</accession>
    <name>H1VQE7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_12449</name>
        <name evidence="3" type="ORF">CH63R_11369</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF42453.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="539" mass="58805" checksum="5B58C53289D7AC2B" modified="2012-03-21" version="1">MPNSFDRLEKLFSRRKDLTIQTDQSMPDSTGPRGASVDRSFPQPSFIRPNVSRMKAREERIVASQNEKRAQSLPEAQSERISIHLAHLSSSSTTALTLPTRSMSLSHRRESQPVASLRGFDFPLPPTSPSSGSPFGSPKTLPTSHKVSLEHRHSSVILPPNRSHTPPGSDHDDDSSIKGSQGRPSSSLSRDLLTPAASPEMKPIHDTRSQDSAELCLAKRKAAAATTRRRREEKAAALRRPQGQSRPHRSITSPSQILKGGNVTDFFTLSDDDILEEEPEFEDAPGTPMTPAPLRLPPSPPTPASTVSSFRSKRRTSSIYTDDVAKEGALQVAQIAAKHKFDLIYIVNLWPESGSESSSPTFRSSMDFSSRPGSKRNSLLGPMEGPMVDSSPGMTGRLLAAYGLSNLTSPFRISATVQSKILKQEGWMEYRSDDAQAGEFARGYGHAFHTDTGRRGSTNSSPRSSSVRDISLNDHGIVFAAYRHPGKGSGAAGCTKEELEALRVDAEGLVDYLVAIHKARRLRDPMTLHTLIDEEATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VW39</accession>
    <name>H1VW39_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Cell cycle control protein cdc123</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">CH063_00071</name>
        <name evidence="4" type="ORF">CH63R_02372</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006902">
        <property type="protein sequence ID" value="CCF44450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018297347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VW39"/>
    <dbReference type="STRING" id="759273.H1VW39"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02372"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:eukaryotic translation initiation factor 2 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF44450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1W065</accession>
    <name>H1W065_COLHI</name>
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        <submittedName>
            <fullName evidence="5">Galactoside O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_14813</name>
        <name evidence="6" type="ORF">CH63R_13413</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
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        <property type="protein sequence ID" value="CCF45877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR04286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018308387.1"/>
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    <dbReference type="eggNOG" id="KOG4750">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hexapeptide-repeat containing-acetyltransferase"/>
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        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hexapep"/>
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        <property type="entry name" value="Hexapeptide_acetyltransf"/>
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    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
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    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
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        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
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        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
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        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
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    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF45877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04286.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="219" mass="23845" checksum="47158350AD31D137" modified="2012-03-21" version="1">MVPPVRTAKDENAIAHARTLERVPWCDDYEKMVSGMLYSCMAPELVASRNRARRLAQRFNTYVPDESASADEVASTRVGMIKELFGKIGEDVYIEPSLQVDYGCNITVGDRFYANFNCVILDCAHVTIGDRVMFATGVSLITATHETGLQSRRDNIEYAEPITIGDDCWIGANVTVLPGVKIGKGCTIGAGALVNRDIPDYSVAVGVPAKVVKKVDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2Q2</accession>
    <name>H1W2Q2_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_15415</name>
        <name evidence="3" type="ORF">CH63R_07372</name>
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        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009043">
        <property type="protein sequence ID" value="CCF46765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157125.1">
        <property type="nucleotide sequence ID" value="XM_018302347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2Q2"/>
    <dbReference type="GeneID" id="28866454"/>
    <dbReference type="KEGG" id="chig:CH63R_07372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07372"/>
    <dbReference type="eggNOG" id="ENOG502R14R">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1299632_0_0_1"/>
    <dbReference type="OrthoDB" id="4849300at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="31"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="140"/>
            <end position="151"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08607.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="213" mass="23488" checksum="130C444058B0EAE4" modified="2012-03-21" version="1">MFGTAMIPAPGPIYDEQDLADLAEDFRRSKESLKAAGRRLTSRQTSRATRASRASIESRGPLSSNEDLDLHVDLPPGILADESPVSSPPSRPPGHPPGNTTRKTKRSSANRSERKAERVAGVQPSKRRRGFRARLRRILGRNDKLEVDPDAPHSQFQAQEPKKQDHQDKDSQRSPEQKTTPKSGPEPAEAEPSSLKETTPRTSISLSKNDKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="3" type="ORF">CH63R_01603</name>
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        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009198">
        <property type="protein sequence ID" value="CCF46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164940.1">
        <property type="nucleotide sequence ID" value="XM_018296578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W369"/>
    <dbReference type="STRING" id="759273.H1W369"/>
    <dbReference type="GeneID" id="28860685"/>
    <dbReference type="KEGG" id="chig:CH63R_01603"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01603"/>
    <dbReference type="eggNOG" id="ENOG502S054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079417_0_0_1"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="183" mass="20958" checksum="37E9D666D66259E4" modified="2012-03-21" version="1">MPRLSDAIKDDHRKIEQAYRYILTSTTPEDKNRWRNELALELARHCISEEQVLLPILKDRLADGDSRGAKNHTDRESLKEKICRLKAIPVTDSSFEPELKALWVDMAAHVRDTDHQDVARLEECLTITESEELARQFRETMSMAPTRSNRSADRGPPSQLITDFLATKSGSLKDMDPILRGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5K0</accession>
    <name>H1W5K0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 7">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04275</name>
        <name evidence="9" type="ORF">CH63R_11649</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 7"/>
    <dbReference type="EMBL" id="CACQ02010122">
        <property type="protein sequence ID" value="CCF47764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153464.1">
        <property type="nucleotide sequence ID" value="XM_018306623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5K0"/>
    <dbReference type="STRING" id="759273.H1W5K0"/>
    <dbReference type="GeneID" id="28870730"/>
    <dbReference type="KEGG" id="chig:CH63R_11649"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11649"/>
    <dbReference type="eggNOG" id="ENOG502QU6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000077">
        <property type="entry name" value="Arabinogalactan endo-beta-1,4-galactanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005133634" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF47764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="350" mass="38061" checksum="A6F4CAFF58AF6864" modified="2012-03-21" version="1">MLASLASVFLLALSTANAALTYKGADWSSAPIEEKAGIKYKSSAGASQSLEVILKNAGVNSVRQRVWVNPSNGDYNLDYNLALAKRAKAQGLSVYLTLHFSDTWADPAKQGIPSGWPSDIENLSWRLYNYTLEVSNAFQKAGVPPAIISIGNEIRAGLLFNTGRTSNWSNVARLLNSAAYGIKDSTLSPKPKIMIHLDNGWDWNAQNNWYTNLFAQNLLKVADFDMMGVSYYPFYGSGATLSALKTSLTNLANKWGKEIVVAETNWPTSCPSPAYAFPSDLKDIPFSAAGQTTFMKRVAAVVAAVKNGKGVYYWEVGWMNNQALGSSCPSNTMFSWPGTALSSLDVFKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRS3</accession>
    <name>A0A1B7XRS3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_13704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150996.1">
        <property type="nucleotide sequence ID" value="XM_018308678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRS3"/>
    <dbReference type="GeneID" id="28872785"/>
    <dbReference type="KEGG" id="chig:CH63R_13704"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13704"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="646" mass="68309" checksum="15E62C958203D10A" modified="2016-11-02" version="1">MSGFQIPGLGFAKPNEMLPPLPPDVLAAAASFEGIDTNNSTTQQKQDQTTNQNEDTNMGESIETQSAPAPEAQSVAAPVPAPALEQANSNEPEPEPMNVDDATEHPSLTDALEAMISGLDPTPPVQTRVAAQEAPAAPQDTSMSQPADGALAASVAAAEQPAAEGEHPEWEVDSSPYESSSESSSDDSSSDEESEAGGYQLLGVEETARMLMEMEGGSDDEGGNDAGKAGGSGHLRTKNEVAVETVPKPDVVLAADDKIEELGLVDQIVENILVVKAFTPGEYQVLDTGSVLCTEDRKVFGVVWETIGKVLQPMYTVMLSTAEEIKEAGLAVGAKVYYPPAHAKYVFTQPLKSLKGSDASNIHDEEVAEDEMEFSDDEKEAEHKRQIKQKKKEARFGKGGAEGGRGRGGREPHPLRNEVSAPSVEGGLNYDDEDDGPYKPLARPPGFGQVPPTQQSFTTEPEPGRFGGRRGGRGDFRGRGDRGRGGRGRGRGGHGGRGDHRDGYSAPAHQRHSSSQQEGGQQQPQGQWGGNGGYPAPPPAQNYNPQQTAPAPTAPSFNFPFPGLPGQQGFPAVPPPPPGWPAQGGQSAQNPQGAYINPAFFAALLGQMQQGQGQQGGQQQQQQQGQQPPQQPPQPPHQWGAQPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSE7</accession>
    <name>A0A1B7XSE7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type I polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_13919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151211.1">
        <property type="nucleotide sequence ID" value="XM_018308893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873000"/>
    <dbReference type="KEGG" id="chig:CH63R_13919"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13919"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="242"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1754"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="242"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="398"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1842" mass="202838" checksum="CF8B3291AB348A4D" modified="2016-11-02" version="1">MVDHGVSQSTVTVACVNSPSSVTLSGDLDVIERLEKDFSRDQIFARKLKVKSAYHSHHMLPMAQEYLKALQNIIQPKLKWHKIIYSSPVTGDLIDSPEKLDPQHWVNNLLQPVQFSKSFEKMCFATSAEEPAVDFILEVGPHSALAGPIRQICNAPGLKGINLPYASGLTRGRNAGVTMQSAAGALWCAGYPVDIAAVNCQQSRENLRVIADLPPYPWNHSNRFWQESRLNVAHRHRKHVRNELIGSLLPGPASTSPMWRHFLKASDLPWLRDHLVQSDIVYPGAGGIAMAIEALRQFSEVSEESIDGYCLRDIQISNALVIPDTEGGIEIQLSLHPCNSKNLEPGWYEFSLKSPSSDGESWTEHINGYISQRQKPNISITPVPISNGQKADLEKDYSRNVESDVLFARLRKMGLHHGPTFQNMLNIHASDSGSKFQFKVADVKSAGSHLLHPTTLDSIFQGAYAALPVESFQDSMVMPRAIEEIFVSQLITSLPGTRFESLATVNRLDKSGFQSSVSTHDLSVPGTTLLEVKGLFCQAVRGISEGHHSHEPPKLLFKMHWHPDVTLMPLSNLKDPLKYKIDSKELSVNKKLVRAAWYFIQDAIQDLSADETALANMEWYHKSLYTWMQCNYEAGLVGTLTRGSASWAKTSKGMKHMLLDEVASESVNGRLLCRIGRNLPKILRKQAAPLEVMMEGNLLYEFYGKALRCNRSYDQVQKLVHLYSMKNPRAKVLEIGGGTGGCTGSVLKGLSEDTPDGRYRFSTYTFTDVSTGFFEAASKKFASYGDMINFKKLDIETDPVEQSFEAGSYDLIIACQVLHATKNMETTMKHVRKLLKNGGKLVLVETTKDTLDVQLVFGTLSGWWLAEEPERKGGPNLTLSHWGRVLENCGFSGIDLDVRDMEDDANYSFSVMTSTATTTPSYPHEVAILSPLMGVPMNWTNELEKAIQSTTGAITTTSDWTSIDATGKVCIMLVEMIAPFLSRLDREDFMRIQRLLTTARGVLWVTRAGLIDGSEPDMALHSGLLRTLRMEDAGRRYVSLDLETTESPWSTKNAGFIVDVLKTSFDFSFAQQEVDCEYAVRDSLLHVSRIYNHDTENRALAPESVTPEPELKEFKATDPSMDLRMEVGTPGLLDSLRFREVEHCDAALEADQIEIEPRAFGLNFRDVLVALGQLDETIMGYECSGIVTRLGSEAREASGLSIGDRVCAILRGHWATRVSINWPCAVRIPDNMSFEEAATIPMVFATAYYGLYDVGRPARGETILVHAATGGVGQAAVMLAQQRGAKVFVTVGTEAKREFVMKEFCIPKEHIFSSRDTSFGPALMAATNGKGVDVVLNSLAGPLLKETWNCMARFGRFVEIGKRDMEAAKNLDMSPLRRAVSFAAVDVFQLGKYKGGVLQDALCGVMEMFEKKQLRAVAPMTTFSASDVDKAFRLMQSGKHMGKIVVVPKKTDLVKVVSSPKAARLSPDASYLIVGGMGGIGQSIARWMARHLGCRNLIILSRNASKHDDCVPLVAELESLGCRTMVRDCDVSCEADFRRVIADARGRYPPVRGVIQAAMTLNDSIFPNMKYEQWLAATSPKISATWNIHNNLPDLDFLVLLSSLTGLGGNTSQANYSAGGTFQDAFAKYRTSQGLPGVSIDLAAIQEVGFVANTEGVANRLTKTGLADIDEATLHKIVETAIQNPRRPVDLSQLITGILEFDETSTVAWVNDRRFSSVQLNHTGPSGSRGRTDQQPGAAARLSDLLQSATSGMDAVALILDAIVSKLADMFGLDVAEIDKKHPVSKYGVDSLIAVELRNWLVSSAGAETTSIFDVLHSPSLSDLAEKIGEKSRFVASVVKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTI8</accession>
    <name>A0A1B7XTI8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151588.1">
        <property type="nucleotide sequence ID" value="XM_018309270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTI8"/>
    <dbReference type="GeneID" id="28873377"/>
    <dbReference type="KEGG" id="chig:CH63R_14296"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14296"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="327" mass="37117" checksum="7CEFB805972DB44E" modified="2016-11-02" version="1">MATPTRIPRHPANNTFCSHKSLPVPFQTRLLKDASTPEQLQSLLPASYRTGPDGADLAPPGLDNLAFLEAELGQGRLAKLSARLWMAGRPIPPRALHYQRLLGREIVVAEQMDLHLVWASGRIHVKPLPPFLLEPTFWSDHLSCRGGYGCSRSTDPLCRHRMLWKCSLGFLFSYAGLICHQSDFFIAKEMHLIPEAVEWSDWRLFVSQLGTEHIYNDIDRRFIYGELRLSRLNKLQYLESGLAFRGYMPHWNRYGDFFHDHFAWLASATVYIAIVLTAMQVGLATTSLAENDAFQSASYGFTIFSIVRPVFATVLILLLFCCIFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTR0</accession>
    <name>A0A1B7XTR0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myb family transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_14364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151656.1">
        <property type="nucleotide sequence ID" value="XM_018309338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTR0"/>
    <dbReference type="GeneID" id="28873445"/>
    <dbReference type="KEGG" id="chig:CH63R_14364"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14364"/>
    <dbReference type="OrthoDB" id="4790690at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR03138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="440" mass="49491" checksum="861785DB76A5457D" modified="2016-11-02" version="1">MSRIRRNWTAKEDKLLCAAVQKAEEESRPLLWRELAKSVPGRSNKDCRRRWWNSLANNHINKGPWSEEEDERLFTAVQTYGMNWSQVAAEVRSRNSDQCSSHWSQVLNPNINYCDWAEEEDANLLHEVLTHGTNWATIAGFHTPIRTTLALKNRYSTLRLRNENKKNRQGESDTIGRKRQSSGPNSVSSQSQTSQWELLNLTDPALFKPAAQSVGSKSTGSNNDDDEDDDDSEEDDCDDNEEDNAALNQSSGASDKGERPQRRQSASREPLSSNRPTLLKMPGSEMLETQVDNCMQFESLIESCYPSASTRPFRNEDPAPTSNQSQDSGPTHKDRTAIHLGEPKTDDLHFSPTGLMGSPITMDTKMTDSGFVNADCVMKDKPYSATTPLWLRQPDEHPVPFPCHFNVSITMACDQSQVQAIMTNLSHLGTNITLNFQRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU78</accession>
    <name>A0A1B7XU78_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose-binding family ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151839.1">
        <property type="nucleotide sequence ID" value="XM_018307422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU78"/>
    <dbReference type="GeneID" id="28871529"/>
    <dbReference type="KEGG" id="chig:CH63R_12448"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12448"/>
    <dbReference type="OrthoDB" id="2141514at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601084" evidence="1">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="72" mass="7708" checksum="C088CE46C54AE72B" modified="2016-11-02" version="1">MKAFAAFALVAAVVATDHGPSYSFEVESLVNHTFYQPLQSAVGSDLKLPVIVWGNGGCKPCTFGCSKRDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUA2</accession>
    <name>A0A1B7XUA2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151832.1">
        <property type="nucleotide sequence ID" value="XM_018307415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUA2"/>
    <dbReference type="GeneID" id="28871522"/>
    <dbReference type="KEGG" id="chig:CH63R_12441"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12441"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="546" mass="58759" checksum="074700B79CAB073C" modified="2016-11-02" version="1">MTLWDCIVVGGGIAGSVVSNRLLEQDSTLKILLVEAGTNTHAVENIEWTDMNNAIGGEYDWGFSSVPQVHLNNREIVSPVGKGLGGGTIINGAAWVRGHKVDYDIWAERVNDTRWSYDGQLPYMKKTETLFDNSTNPLSHGHMGPVKIQSPGSTNRVFPLREPLLESWREIGIDALPQLDNNAGNNLGVADLQENRDKGKRQLSSLIYSLEGVTVLTDSLVAKVLVEKSPLGHLVSRGIQLDNGTKIFGRETILSAGAYRTPQILILSGIGPADTLKKFNIPVILDQPAVGQNFHDHVLIPTVWQLKNASAGYAKESGNPVFSESQYNLGAFIDFMAITSLPKEGLFNAIAEDEGSVPNAATHPLLKQDRAHSSHLLQYSGVSADGSAVLMISVVFINSARGSVTIQSADIKDAPLIDPNFLATSVDRYAARETIRRNIRLLTSGDTVLGREIVAGELAANPLTAESTDEEIDARVREMAGGCYHPAGTASMGTVVDTDLRVIGVSGLRIVDTSVFPVSISGNLQVAVYALAEQAAEIIKSTMKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUC8</accession>
    <name>A0A1B7XUC8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151866.1">
        <property type="nucleotide sequence ID" value="XM_018307449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUC8"/>
    <dbReference type="GeneID" id="28871556"/>
    <dbReference type="KEGG" id="chig:CH63R_12475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12475"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7279" checksum="A64E9F4358F487FB" modified="2016-11-02" version="1">MSLSLDGNRPAAMTVFGTGIFEKRDFQPDQTKEYQQGLPEAFSQVLGNPRLLNWVEFSGCQLAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWW3</accession>
    <name>A0A1B7XWW3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152785.1">
        <property type="nucleotide sequence ID" value="XM_018308368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWW3"/>
    <dbReference type="GeneID" id="28872475"/>
    <dbReference type="KEGG" id="chig:CH63R_13394"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13394"/>
    <dbReference type="OrthoDB" id="4851628at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601156" evidence="2">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="325" mass="31443" checksum="736BE7244C1CC726" modified="2016-11-02" version="1">MRYFTPVFLLASALLVGINGAPAGNDVAPRDQGELGPQADAPRINAPVAVAAAGQPNAALAARDDQPIQPRLLKTILANLLQKNNKNKNKNKNQNKNQNKNKKAKAKAKKAVTPSPAKSSAPARPSGTPSGAPRAPAPAAPPRPPAAAGPATPAKNANNPKAPAAAAPKKAGAATGAGAAAAGGGAADATKGNKNPPPAPAKPAPVPVGGIPAASKPKPQTGSTTKSSQPKATTPPKAAPPKAAPPKAAPPKAVPPKGANPNNPAPAPAAALLAGALLGGAQGAPPGAAPQNAPKPQAPVPKPQAPPPAGGTNGLPLAVPGRNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXX0</accession>
    <name>A0A1B7XXX0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153102.1">
        <property type="nucleotide sequence ID" value="XM_018306261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXX0"/>
    <dbReference type="GeneID" id="28870368"/>
    <dbReference type="KEGG" id="chig:CH63R_11287"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11287"/>
    <dbReference type="OrthoDB" id="3600127at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="788" mass="82861" checksum="C53D4071A7056328" modified="2016-11-02" version="1">MQPSLPTCTLRRYHRPACMGGVVADLKRCLGGDAMRDGRQRCNLTKSRPRIQLVFSLGWLVGCMWWVIEACVALAAPRYCRSATRCRRPPSFDKAPVAVLSETLLSPPPFLSSPTVATINLVPRSEPPKSTFIVTVIRFRRTITSIVNMRGIYMGLAAMAMASVNAWEYPYCELDGCYRNLIDERFEQEAKGFCVGFLQGTTTVAAAIPTNFNNCQGDFKAVSSACSCITYGLTSTVPATTSTSSTSPPLTTVSTTGAVSTTTSTSKEQPPTTPVTPCTSSTAVSSTKEHPPTTTASSSTSSTAVSSTKDITTSTTKVYNTTTPATDDCTTSTAISSTKDVVTSTSKVVSTTKNYNTTTPATEDCTTSTAVSSTKDVITSTSKVVSTTKNYNTTTPATDDCTTSTAISSTKDVVTSTSKVVSTTKNYNTTTPATEDCTTSTAVSSTKGHNTTKSHHSHSVETSTRLPLTTIPYANTTTEKPPHTRTTTTKLTTKTVYTTRVETVTQCPSTVTNCPHRPVTTTRTIAISTTVCPVTEESTKPVTTVPTTKLTTSTIYTTRVETITRCPPSVPDCPDRPHVTTKTIAVSTTVCPVTEESINPVPTPPATKPTSWTTSTIYTTKVHTVTACHGNITNCVITSRITTVTIPVSTTICPITESVPPTFTTVLPVPPSKPPAPPVGSPSVETHPIPPASSPLAPPASSRPAPPPGTNPFPPASSRPVPPPATQPAPPTSNQPVRPTGTPPVATTPVATPTRTTNTPVLVSGNAADHLNSGFFAAAAGVVVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYE1</accession>
    <name>A0A1B7XYE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153288.1">
        <property type="nucleotide sequence ID" value="XM_018306447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYE1"/>
    <dbReference type="GeneID" id="28870554"/>
    <dbReference type="KEGG" id="chig:CH63R_11473"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11473"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="328" mass="36886" checksum="6CD2A770CEC003C3" modified="2016-11-02" version="1">MGAQAGDMASRRCFPSAEIHCYVFIERGASKQPIPNAELALTSGVYLSSVGAEKFVLKNMIPGDFEYNQDLQNSVASCPNLRTAIDAVLDFELLVYPFLAGDLLQISQKPLAPATRKYILKSALRGLAGLHEKGIIHTDIKPNNILLDYDVAGDDITVRNVQVSDLEDAMVIPPGKNLRDCLRGNQLWRSPESWARARQNTPSDIYSFGVVIIYVMLNEMVFRVRDEELAAKDAWRHVLRRHISYFADMDGFGGLLSHIGEDNPFFNRLIDLTTDFDASKPRSPFALWHYVDEELRDLIGKMTNFDPARRITAHEALEHPWFSKGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYG1</accession>
    <name>A0A1B7XYG1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153331.1">
        <property type="nucleotide sequence ID" value="XM_018306490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYG1"/>
    <dbReference type="GeneID" id="28870597"/>
    <dbReference type="KEGG" id="chig:CH63R_11516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11516"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601181" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="62" mass="6720" checksum="4688C1A189DF43EE" modified="2016-11-02" version="1">MKSYIQIFALVAPLLALAIPVPADTQATTDADAESFFIQTDVGWFDGGDSKKREAAKKPESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYI6</accession>
    <name>A0A1B7XYI6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153327.1">
        <property type="nucleotide sequence ID" value="XM_018306486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYI6"/>
    <dbReference type="GeneID" id="28870593"/>
    <dbReference type="KEGG" id="chig:CH63R_11512"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11512"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="145" mass="15460" checksum="2C65A9A34900E47A" modified="2016-11-02" version="1">MSRGPAYDAKDNGNASDEEEEERGRARLRADEALAFAVALAEQQRHQHEQDQHQHHHQPPVTPTVQPMAPFGHLPLGSDRGRALAASANNRSRSRSAAPSLPIPIPGAAGSRRAAFREAEAARRAAAEDDSGTDSGDGSPTGRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYW4</accession>
    <name>A0A1B7XYW4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153457.1">
        <property type="nucleotide sequence ID" value="XM_018306616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYW4"/>
    <dbReference type="GeneID" id="28870723"/>
    <dbReference type="KEGG" id="chig:CH63R_11642"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11642"/>
    <dbReference type="OrthoDB" id="5396360at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="103" mass="11829" checksum="E2742B6EE5457F3C" modified="2016-11-02" version="1">MALKRNRVQTLGVRLRLGNGRPSFEPEFISFFHIQADLDVLRENIERIGTAGYRVVSQIDDAIARIEDEVEKLDATTKGQQNDIDHKKADLNSLRREKEIPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y273</accession>
    <name>A0A1B7Y273_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_10225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154623.1">
        <property type="nucleotide sequence ID" value="XM_018305199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y273"/>
    <dbReference type="GeneID" id="28869306"/>
    <dbReference type="KEGG" id="chig:CH63R_10225"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10225"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="121"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="54630" checksum="8C6C8C5E4314F053" modified="2016-11-02" version="1">MAGIIWNRGEEWREAWDFRFKWTEGHFTPDDLRPMMYTYDELGAKALDRLGEISPPTKAPHPGEKADAAPGPKPHRDLYALLRDNADSDETLGKLWAQVNTVPSWVDWAQVERGQQVFLRYGGPAMFALAFQSLVGGFGSRRVVETLARTGGFGINITRRRLLETFQHILEVTRDLGSVQPGGDGFASSVRVRLLHAAVRRRILALAAERPSYYDVHAWGVPVNDLDSIGTIISFSATLLWISLPRQGIYPTRAEKADYLALWRWVAHVMGTPTDTFASETRARAMMESLMVSEIEPSDTSRVLANNVLTALCNQPPSYASREFLAAETYWLNGSRLARALAVERPPLRYFLLVAGQCIFFMTVSYARRLFPNWDRSLNEKLQKALFGMVVHKTEIGALGEETKFEFKYIPTLDVTSTEADARPDHLARYAKGPAAGMSIRRRLQFAEWRSLAVLLLAVAAAGLLAWLGIRSASVLFRTLAGMTPLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Y9</accession>
    <name>A0A1B7Y2Y9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154899.1">
        <property type="nucleotide sequence ID" value="XM_018305475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Y9"/>
    <dbReference type="GeneID" id="28869582"/>
    <dbReference type="KEGG" id="chig:CH63R_10501"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10501"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="53602" checksum="408B13C47B29614B" modified="2016-11-02" version="1">MRKFFKEAKQKIEAEIAAITGDDDPQKQQQQQQQQHYPPPPQPPAQGFERAVFAHFMTDGKQNPQLSNTCDYTVDEFKVDIRLAQEAHIDAFVLNFGIHEEAIAKLPDVFAAAEQTGFKLLISFDYEGAGAWPKERAIDILSRFGPSPAYFKRGWQPVVSTFEGVGSAADWHEIKAATGCFFIPSFSSVGAENALNTGVVDGLFSWAAWPHGNTRKLDEGLDASYRHFLGPHRPYMVAVSPWFYTNLPTWNKNWAWKGDDLWNDRWNEILAMRPEYVQILTWNDFGESHYIGPLHEKQFGAFEYGKAPFNYVRDMPHDGWRLLLPFLIDLYKYGTAAVTREGLVTWYRLHPGDAGDAGGTTGNTSSHGQELFHPAEIMEDKIVYSALLAGPAQVTVSVGGDAREGAWDDDGVPRGGVGVYHGSVPFDGRTGEVVVTVHRGGDVAVQVQGRPITTECSHGGMNNWNAWVGAANSHAETHAVAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y482</accession>
    <name>A0A1B7Y482_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_10942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155340.1">
        <property type="nucleotide sequence ID" value="XM_018305916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y482"/>
    <dbReference type="GeneID" id="28870023"/>
    <dbReference type="KEGG" id="chig:CH63R_10942"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10942"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="57631" checksum="B0E15055C94B89B9" modified="2016-11-02" version="1">MTSHRDRPTGTIDLKVSFETILPIPVLRHEEVAEVKTLRPPHHINERFTSPQSWSPLRKRLVLCLLCTATCFASVAASSYAPAKAAMAEEWGVSQVSALVGITTFTTGFALTPMVLAPISEVWGRKLVFTLTGVLFVACQIGSAATQSYPGMLVLRFFAGVGSSTYSSMVGGVISDVYGPKERNTPMAIFSGGALFGTGLGPLFCGFIVQNLGWRWIFWTQSIVNAIVVLALFVFVPETRQNVLLRRKAAALNHWYDDIGTKSTVNFRVTSPNAQQVIMCEKIAWKFEHDEEHESIVRKIATSATLPFALLFTEPIVFFFSLWAAFSWAILYLGFAAVPLIFTHVYDFDLSSANAVLASSCAASIIATVVSICQERWLDGLSNPRLPLHRPERRLYFSCVESICLPIGLFVFGWTARIQIHWIVPAIGIGISTLGIYSVYLAVFNYLADSYHGYASSALAAQSFCRNFIGGIFPLVTVQMYTNLGYGPASSLLGGIGLLLTAGPWVLVAYGETIRAKSRFANKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5B8</accession>
    <name>A0A1B7Y5B8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_08713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155710.1">
        <property type="nucleotide sequence ID" value="XM_018303687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5B8"/>
    <dbReference type="GeneID" id="28867794"/>
    <dbReference type="KEGG" id="chig:CH63R_08713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08713"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="227" mass="25761" checksum="5C30D312A3CA40C5" modified="2016-11-02" version="1">MDIRLLKSADLPLIQHANLENLPENYFLKYYLYHALSWPQLSYVAVDVSRPKRTPYDYPKIVGYVLAKMEEEPADGIAHGHITSLSVMRTHRRLGIAEKLMRQSQLAMVETFGAQYVSLHVRVSNQAAIHLYRDTLGFKTEKTESKYYADGEDAFCMKLDLGYIREQVQDERDREEEKDVEPVDEGEAVGDVGRDPSATAAADKKRKVKVGRGLGVGELVEKNESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y671</accession>
    <name>A0A1B7Y671_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156067.1">
        <property type="nucleotide sequence ID" value="XM_018304044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y671"/>
    <dbReference type="GeneID" id="28868151"/>
    <dbReference type="KEGG" id="chig:CH63R_09070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09070"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="62" mass="6725" checksum="04833703978B2CD9" modified="2016-11-02" version="1">MAENQTGELVAVQFRVVLGLGSKPIISPVVGRRLPVPKLSSYNPAFHCEECDGGVVEVRMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7A1</accession>
    <name>A0A1B7Y7A1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156306.1">
        <property type="nucleotide sequence ID" value="XM_018304283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7A1"/>
    <dbReference type="GeneID" id="28868390"/>
    <dbReference type="KEGG" id="chig:CH63R_09309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09309"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="95" mass="10682" checksum="D6774FCD9D8110FC" modified="2016-11-02" version="1">MCCCKHCHRHPSFPPLRWVNIRDLGSVAGSAICPESIYRCGTLEAATEDPEAFEWLATKVKPIFDIRSPRERKHHPAPKFKGVANSQFNSTAFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7G9</accession>
    <name>A0A1B7Y7G9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156494.1">
        <property type="nucleotide sequence ID" value="XM_018304471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7G9"/>
    <dbReference type="GeneID" id="28868578"/>
    <dbReference type="KEGG" id="chig:CH63R_09497"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09497"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="97"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="572"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="698" mass="78335" checksum="070185728B4EB725" modified="2016-11-02" version="1">MSRSDHLTGFFHRPNHPARQGQAQQQQQQQQQQQQQQQQTHQQTRQQQAAYEDVTDASEKSYSATPPARSSSHMHSSSSHNNSSVVFDPDEMATGVELYFKYCHRQPIWCFERDEVGAYDSLPEELASSILALTSRFSERRDHMQLYSSNAKTLVMLRIANGTVDITTIESLCLLSYASFIDGNVHLGQFHLGLSLQLCRSAMLDMESVYAVEDPTTDRKKRLFWSLQVLEQSYGRQDGLLSFPNDVRRPTLPASGNHTEQDFSKAPPLPRDELGTSTPSEPGIWNTSVCLGWVWSQVRKYVSDCARNILKEPWRHDSTYAKVLSDFMETENRIPMCHRYDSVKFYERTMDELKVNRDYWAPWLKEQFTYHAIPTVLNHPFLYIVGAQHNPNLGIPNTFWRRSSEQALLHATWIVRMIDMVVDKQVPLVDPFFGHVAAIAATVHLYYCCAAAARLKNKSNTDFAKCRRFLKSFIPCSAACGALDRNLDRMTHIATGTDNMDVEDWMPSKMYLSVPLMWEILQFNSTTDLQEIPTAGLLDASLTPAVPPVDTSDGSTLEIIVATSPEISINIADGGQEAPSYKRPPVSSGQGGGNANTNNSTNNNSRNNNTNTNTSANTATATTNTATTSSSSSAPSRTAVFDPPTVEQIDSLTFNTTPWLYADPSQLVGIGDMSYPQSEPGNAWWEGENFNNILFNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y803</accession>
    <name>A0A1B7Y803_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156687.1">
        <property type="nucleotide sequence ID" value="XM_018304664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y803"/>
    <dbReference type="GeneID" id="28868771"/>
    <dbReference type="KEGG" id="chig:CH63R_09690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09690"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="69" mass="7687" checksum="1645E45577870742" modified="2016-11-02" version="1">MKKRLQATYRHAVRPIPQSILPNRPRYKATLYKLEITVNMPSNSSGEAGNGKPNKSPSLAQCRSQTHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8N2</accession>
    <name>A0A1B7Y8N2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156917.1">
        <property type="nucleotide sequence ID" value="XM_018302139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8N2"/>
    <dbReference type="GeneID" id="28866246"/>
    <dbReference type="KEGG" id="chig:CH63R_07164"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07164"/>
    <dbReference type="OrthoDB" id="3669279at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF6">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="108"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="286" mass="30181" checksum="1844D20308ED0889" modified="2016-11-02" version="1">MSLSTAFAADSAWPLWDSEPVDGAFEIDLPGGTIDQGVVTKVSRPWLFGYKPTTTPNGRAVLVLGGGGYVQLMVGREGVAVARWLAALGFEAFVLVHRFPTAETGPSSPVDDARQALRLIKEKGAGPRGLALCGLSSGGHLASALLAEYPSSWALTAGAPVPKPEFAILGYGPISTNAKGHTIVPNKAPLDPPAKQELYDIVIPDQQIARPAPPAFIVYSATDPIVPVVNAYRLAQGLQAAEGSVELHVFADAPHGFALDTKDLPVSKWPSLAEAWLEQKGYLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y924</accession>
    <name>A0A1B7Y924_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156985.1">
        <property type="nucleotide sequence ID" value="XM_018302207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y924"/>
    <dbReference type="GeneID" id="28866314"/>
    <dbReference type="KEGG" id="chig:CH63R_07232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07232"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7111" checksum="E818EBFE7E837627" modified="2016-11-02" version="1">MDPPPPPNVTTTIVSRSKPQRSGDLSLFAPGDDGLQLCHVQNLCNRQHADLDLATSSPGLASDTATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9G9</accession>
    <name>A0A1B7Y9G9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_07263</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157016.1">
        <property type="nucleotide sequence ID" value="XM_018302238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9G9"/>
    <dbReference type="GeneID" id="28866345"/>
    <dbReference type="KEGG" id="chig:CH63R_07263"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07263"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="477"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR08498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="689" mass="75684" checksum="AFB57E3B225D35B2" modified="2016-11-02" version="1">MTSKDHAGGAGAPAGDDGFPKPQFPGRSDRPGPPSIISSRMTDIASDDGGEAVVQTLSENPRRKSGLASDSLSRPGTAKTGMSGPWEGRRRGPPPRMNYITSLSEKRGSTGAGSTAGSIASRPPSSTSRSHVPSLTSSAFFRPMSSQKLQAQRGGSRPATRQQPTFEDVESEPGQSAAAAAAVASGGPNARHSVISNPVSNPVARLQRQLSDDDEMRAPPSRGTEYTEQGTYDRITANTSPTHGHHAAGSMSESVTPLQRNQRNSRNLSVTVDRGFKERGNQPSPVKSPRSFRSSFLLPGRSDQGQNKSNRSLPGGEKLSSTASTPQLNPVDLSRPADKTNLKKSMSNLGYVFQYFEGNTVFCIGGRFQNTKHRPVNVATGLFIVIPAVLFFVFSAPWLWHNISPAIPITFAYLFYVCISSFLHASVSDPGILPRNLHVFPPAEPTEDPLRLGPPTNDWTLIKSAESATAAMEVPVKHCRTCNIWRPPRAHHCRLCDNCIETHDHHCVWLNNCVGRRNYRYFFAFVSSATFLSLYLLGASLAQILIHMNRSNISFGKSIDEFRVPFAMVIYGFVSFLYPAALMGYHVFLMARGETTREYINSHKFIKKERFRAFTQGSMLKNWIVVLCRPRPPTYYQFKKKYSVGDQRLGAFRDQPKNDAQGMEMHNVRPSTGFQGPVSLRNEANTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA88</accession>
    <name>A0A1B7YA88_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioester reductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157358.1">
        <property type="nucleotide sequence ID" value="XM_018302580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA88"/>
    <dbReference type="GeneID" id="28866687"/>
    <dbReference type="KEGG" id="chig:CH63R_07605"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07605"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="557"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116571" checksum="21746D6C1C29E224" modified="2016-11-02" version="1">MAQPQYGRRLIPQVIDDTARTEPDAEFFSVPRSSDPADGWRPITFKQIANAVNRIARRIIDKRGAPAPGTFPTLTYIGPNDARYMIITVACIKAGYKALLISPRNSFEGQMNLFEQTDCNIICFDAAFKDVVQPLLEERQMDAIMVSSADAWLADDEVPHFPYDKTFDEAKHDPVVVLHTSGSTGLPKPIVARAGMLAVADAFHDLDDFMGSENCVKSIMHGSRLFLPMPLFHAAGCYMSTFATVYWRRPVALGFTDRPLTPQTVIDAVEHAAVDNVILPPAILEEMSHMPEGVAALRSLKRVNFGGGNLSREAGNKLVKEGVTVASVIAFTEAAPLPYFFQKNPDLWQWFIIDSDRLGVDWRPASGEDDDIYEQVLVRKQPDDPLQGIFYTFPDAREYNTKDLYRKHPTLPNHWTYYGRSDNIIVFSNGEKLNPVTIEEIVTGHPRVRGAVVAGAMRFQPLLILEPVEPLTSQEDVDAFIDDVWPLVVKANKETVAHGQIGRAFIGVASPDKPFPRAGKGTIQRPMALKLYKDEIDAWYDKAEDGADSLSVHVDVTSQQTMIDSIERLFQQTLGSRPLSADSDFFSAGIDSMQVINASRLLRKGLEAAGASITADAIATRVIYAHPTPRQLAAYLMDRVNATATATTNGNGNDDGENHDIHAMEAQLSKYTRDLPENPVVAGTANKPPPADRNQTVLVTGTTGALGSYLLDFLESDPAVSRVVCLNRSEDSAARQAKMSADRGLASTWTKAEFLCADLSKSTLGLAPEVYDRLLRDADRVIHNAWPVNFNISVETFEPHIRGVRHWVDFSLRAAKNVPVVFISSIGTVDTWAGPGPVPETRLLDLSLPSTGYGRSKLVSSLILDEATRRAGVPTAVVRVGQVAGPVSRDGVWNRQEWLPTIVASSKYLGVLPADLGAMTTVNWTPIEGIARLILEVSGVVQTVPLRDVDGYFHGVNPRTVPWADLAAAVKSYYGDGVIRDIVPFEEWVRRLEASAGATDDMDRNPGVKLLDFYQGLAAAAGHGVEFSMERTVKSSRTMREMQAVTPELMQNWCRQWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAR7</accession>
    <name>A0A1B7YAR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear pore protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157683.1">
        <property type="nucleotide sequence ID" value="XM_018302905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAR7"/>
    <dbReference type="GeneID" id="28867012"/>
    <dbReference type="KEGG" id="chig:CH63R_07931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07931"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="42664" checksum="B34D189370C42C64" modified="2016-11-02" version="1">MEDQDAVKATQDSPPADEPDPKRARRETPEPKPTTVLDEYGDLRLCVGADHAEAPSTYLVCSRTLARSSLVMKKMLFGSFAESRPRDGGQDDWVVQLPDDEPAPMQLMLDIIHGHFAKVPDTMDLDTLHALVVLLDKYDAISVTRPWVQAWLHSAKTGKERAASGRDSSKLLSVAWALGDSRLFSKMQSRLIEICEVDEDGRLIVELLASEVGEDKSCWSLLAEETAPLIPPYIIDYMTAARAQWISTKLQPYLTIYHELTQGKWKCRRESAQSGTSSSSTSSPSHCKAIALGSLVRGFLKMGINITDQDPASSYKESLAVLGSRVDALEILVMPNGGNYNHNDCRKMQATQVRTCSWKLVPLETIGDDCRARLETQATKTGLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB44</accession>
    <name>A0A1B7YB44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_07949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157701.1">
        <property type="nucleotide sequence ID" value="XM_018302923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB44"/>
    <dbReference type="GeneID" id="28867030"/>
    <dbReference type="KEGG" id="chig:CH63R_07949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07949"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="521" mass="57090" checksum="ACE8B966218E6D0A" modified="2016-11-02" version="1">MATEPAGIPVTVDAAIANKRGALKWLSNPGIVKLNCVLALSLVSSYATGYDGSMMNGLQSLDTWKDSFNHPDAQELGLLNAIQNVGQLLALPLCAWSCDRFGRRPSLLASASVLLVGVALQAAAQDVAMFIAARGVLGFGLALNITAAPLMIMELAYPSQRAPLVSIYNSLWGLGALAAAWVTFGTFRIGNTWAWRIPSVLQGVSSIVQLGLCFFIEESPRWLISKERDAEAEALLVKYHANGDAADPIVPLEMEEIRTALRLEAEASRTTSYLSFFHTPGNRRRLLIILCVGFFSQWSGNGLISYYLSLILNSIGYTSQDTQTLINALITLWGLFWGILASTLVNRFRRRTMFLASTLGSLACYVVWTALQATYERQTDLTGAGSPALAKGVLAMIFLYNVTFTVGWGALQVTYVVEILPFHLRAKGLVLYNLFVALALIFNQYANPIGVTNAKWRYYITYDVWLAFEAVVVYFLFVETGKMSLEETAVILDGNEDRLTEEVARRTEKLAMEAGGDGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCH7</accession>
    <name>A0A1B7YCH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158057.1">
        <property type="nucleotide sequence ID" value="XM_018303279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCH7"/>
    <dbReference type="GeneID" id="28867386"/>
    <dbReference type="KEGG" id="chig:CH63R_08305"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08305"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="514" mass="56973" checksum="05306B0EAE5BB633" modified="2016-11-02" version="1">MAILTRLPVTSVAGTAAVAVLVTLLALVVRRRLLHPLRSFPGPWLNSISEIPAAYALATGVQHSYYRDLHAKYGSVVRVAPGELSCIDADAWEEIYGIRKGGANMEKSPIFIGAVSPMDGQTGISLAPNEAHSRQRRALAYPFSNGALLQQQEILQRHVDKLIAALRKMAADRRPVDFSDWYTYTTFDMMGDLCFAEPFGCLDQESATEWSTSVINVFMSAAWDQAIRRVAGVGTPLTRFLVKLLIPAKAAGWRKTHFFNSREKTLRRLADPDRDHKDLIYHILQNNESRKSLSETEIILNMVLMISAGTETTASLLTGWTYYICSHPEAYGKLVAEIRGSFASSADIKWETVKELPYLNATINEALRLFSPAAGNQQRVVPAGGATLGGRFVPAGTTVAVAPWAASHSSLNYAEPDEFRPERWLGDPRFAGDKLHASQPFSLGPRGCIGKNLSYFEMRLIMSHLLWNFDVELDGGKSGESGRAWDMDGEGKNMKVYQTWFKPSLFINLKEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YER3</accession>
    <name>A0A1B7YER3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_06112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158937.1">
        <property type="nucleotide sequence ID" value="XM_018301087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28865194"/>
    <dbReference type="KEGG" id="chig:CH63R_06112"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06112"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="356"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="682"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="983"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="911"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1533" mass="165888" checksum="FF936A19DF9AFE86" modified="2016-11-02" version="1">MDALGFSPPARRSTAGQTVLLQTPACSDTATPGFPLCSGTLASSFFREEILLCIVPCSVAILWGLHRCLRLWSKPVVSQGSVLAARHLAGCIILAVVLFLLFPSSLAVAPAAAVLVSGLFGYLRPGSRPESPQGSRLLTRKMILWQALPAFQLAALLSLVWIATTNTPPDSTSGIAVASWSFSLASSFLLLLVSRLEHSKSRPPSALLQTFLLVTIVLDAARFRTAWFSAGGPVHDEARQLLPVQLIIKTLLLIAESGSKAAVIAIPARRISREEASGIFGTAFALWVLPLLSSGWRKDLTVDDLEPVDEALSSERVLNKLSSAWQRADPDRSHALALTVLRAFWVEVLIIHIPRLAVVGFGLVQPLLVQTTIQYIQNHDEDGTDASFGSWLVAAFAVTYLGLAISTQLCGQLTNRLITRLRGSLVALIYQTMLSLRAETGTSQAAVSLMSTEVERINVAAQWSFSIVPNLLQLAIALRILAGQLGGVSVAPVIVAILCVSAGMRVGQLVPPRQRRWMQAIQRRVGITTDIIGSVRGVKMSGLSATVRDQIQGLRDFELDESKRFRRMQIVNIVIGQFPSIMTPSITFAAFAVVQKLSGGPPLNVVQAFTSLSLLGILISPVTELVMIPNNLGSTIGCLDRIQEFLVREKRDDYRRLTPRRPPTRGHDGETTESPARPQPLITVSDGSFGWRAAEPILHGLNLDIRPSTLTILVGPVGSGKSTLLKSLVGETHRIAGSVEYHTATADVAYCDQDPWILNQSIRDNICGGSGAGHDPGLYGKVIRACQLEEDLGLLPQGDETLVGTSGAALSGGQRHRVALARAVYSGKQVVIMDDNLKGLDSNTASRCFHALFGPGGLLRGKDKAVILATHNAQWLRQADTIVALGADGTISERGSYEELSKSGGYVSSLHVSQQSGHTDNADDDDNKLSSEAEQPKQQNGTQRDKPVSAGAPGPSPNPRARGAANTSSLFYYIKSMGIPSFALFLAMVLIQTFCRTMQRLWVKFWVAANEGGGQQSVSLWAGVYILWGVMTEVAFAAEIFWFFVIVIPHSAKGLHFSVLKAAIAAPLSFFVKTDTGVVINRFSQDMNLVDLPLPIAFLLTFDCLTLTIADVILTCVATGYLALAIPFLAAVLYAIQRVYLETSRQVRLLDLETKSPIFSHFIASFAGLVTVRAMDRTAECQAENLARLDLSQRAFYAMGSLQRWLLLVLNLTVAGLAVLLVGLAVALRDAIDPGLLGVALVSVMGFGQLLTELLNNWATLETSLGAVARIREFEAETPSEQDRDGDIPVAVEEWPDKGKIDIRNVSAAYDDHQVLCDVTLSIKPGEKVAICGRTGSGKSTLIALLLRLHDPSSGTIEIDDVDIASVPINELRESLVALPQDPLFLPGTVRRNLDPFDARDDDAVWAALDKTGLKALFEDKGGLEADLKTDWLSAGQKQLFCMARAVLRNRRVLLLDEATSSLDQATEQVVQDLIRSEFQGWTVVVIAHRLKAVADFDKIVTLQDGRVVEFDRPTTLLEKGGVFASLWKLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHH2</accession>
    <name>A0A1B7YHH2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159795.1">
        <property type="nucleotide sequence ID" value="XM_018298549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHH2"/>
    <dbReference type="GeneID" id="28862656"/>
    <dbReference type="KEGG" id="chig:CH63R_03574"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03574"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="285" mass="32602" checksum="8EFC22988A298677" modified="2016-11-02" version="1">MGRHNKEYSPVYSDERSATSLEDVEVELAAAQERQPSRLSKLGLWAVHAAFMIVYTSIFIVSMYQKNTVSGVFSLLDSPPNAIGDKTHLEVFPIQGPPHGKYTGEPRPEVDQAWKDLLQCRQSRSHPLEKVSEDWVNRWGREHEAVKLPDGGYLGMLSVFHELHCIKRLYQTLSPDYYFPNATEREIATNREHNQHCLEVLRMGAACRGDISIITHMWTDIDAQPIVNQTAPHQCVDFDKVMEYSRDNTVDVYQEDYIVHPKFGPSFPKGNSIKPFKGQEMGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIH1</accession>
    <name>A0A1B7YIH1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160390.1">
        <property type="nucleotide sequence ID" value="XM_018299144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIH1"/>
    <dbReference type="GeneID" id="28863251"/>
    <dbReference type="KEGG" id="chig:CH63R_04169"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04169"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="42257" checksum="636A3BC508D8B233" modified="2016-11-02" version="1">MNAQVSFLDGNYTLIHIPLDLYSVLLQPILRVLLPQTQTLKASKGEPEHELEGLNAESQHGFLNISVTPMECSIVCHSSWAKNVFEPAINDLPKDIAKSVSISKDTYLVLSVISAGMDAAGRVMELTSPLALAGIPIFFITTYYSDFILVPTKDRQTVVKALLARGFELADNNSNFVSPAASVHSRGPSQNNGPPLTPPPSTVAELQVRTFDLLKKRSVSPYVEDDLLLVQCSGRETSQLGGELSHTQRPSLSRQVTGNGHRQTWLDNIDAKLYTAMISALAARPRFISITLAQEDPPSLLLDKSLLGLFGDSLVGDTKTNLTPIFLDLESLPLEATGIVCGVAGTLVQEMRMGDSAGLSYLSTARAGAVILSCEQSIRALEILTPKLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIH7</accession>
    <name>A0A1B7YIH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_04175</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160396.1">
        <property type="nucleotide sequence ID" value="XM_018299150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIH7"/>
    <dbReference type="GeneID" id="28863257"/>
    <dbReference type="KEGG" id="chig:CH63R_04175"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04175"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="386"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="592" mass="61121" checksum="2A0ACF2028D9A5BF" modified="2016-11-02" version="1">MSTKHFINDPTKLVNSALHSLTLTNPSLALDKSNKIIYRRPDPNAAAQVSVISGGGSGHEPSFSAMVGQGLLSAAVAGTIFASPSAEQVRTAIASRVDTAQGVLVTVMNYTGDVLNFGMAVEKARAAGLPVEMVVVGDDVGVGRTKAGKVGRRGIAGTVLVHKIAGALAAQGRPLADVAKVARLTAENLVSVGASLEHVHVPGRAIPSGEDEGTLRLGEAELGMGIHNEPGSGREKADLPGLVGKMLAQLLDQGDEDRAFLNVNSNEVVLLINNLGGVSALELGGITAEVASQLENSYGIRPVRVLSGTYMTSLNGLGFSISLLNVVNTDIGGPSMIQLLDFPTEATGWSSPILKETWEAKNEATREQEADAGQTTKPSDLKYDAAAATKGITAALQRVIAAEPEITKYDTVVGDGDCGIGLKRGAEAILKHISQKPLTGDAVVDLASAVPVVENTMDGTSGALYAIFLNALTGALRSLAPGAADPGVWAAALKQSSDAMSRYTPARPGDRTLVDALYPFVDVLGQTGDVKKAAEAARAGAERTKGMKASLGRTVYIGGSGFEQVPDPGAWGLSCFFAGLAGLEGEDGWEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJX3</accession>
    <name>A0A1B7YJX3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160721.1">
        <property type="nucleotide sequence ID" value="XM_018299475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJX3"/>
    <dbReference type="GeneID" id="28863582"/>
    <dbReference type="KEGG" id="chig:CH63R_04500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04500"/>
    <dbReference type="OrthoDB" id="2128708at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF6">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="336"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="498" mass="54766" checksum="84E81B06559BAC0B" modified="2016-11-02" version="1">MLQPSSDDGTMKKIEVGGNRVTLTPNKPDTSYFYSKTACTNAQAKGYGGISFRIKASSGTTFGVQLASATTCSGEDTSFGFQTTRELGWTFDGTEKLYSLPFSKFTTIDLSKVSSILFTTLSGPVQFGPMAFYCGTTPSEYIVKTLPLTSTSVSTVAAPRGTAAAKLIDDFSAQNLNSLGQWHGGDNDAAVTWVKGKVTLKAPDADFAYYTQFENTCADITAYDGSYLHIAYSGSNKFTIAMQQHNSQCNEAIAPFPETWDSLEAARYATGNNIYIPMSHFNIVRSRVVGLAFKGFYTNEAVTLTKIQIVSSVPDNVHIPSKLPSGNLVFACKRPNSIAFAIDDGDPTYAQEVMEVIRSENIKVTFFTVGAPLRDPSTNLSNIYQDMMTQGHQMALHSYTHPKMEGLPNNDAIAWEYKQDIDAVSDMFNGLKTKYFRPPFGNEGARMRQQLVSTTGNSDAYIVNWNIDVEDWLWATSSQPEKQLEAFQRDLEKARSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKV5</accession>
    <name>A0A1B7YKV5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_04888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161109.1">
        <property type="nucleotide sequence ID" value="XM_018299863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKV5"/>
    <dbReference type="GeneID" id="28863970"/>
    <dbReference type="KEGG" id="chig:CH63R_04888"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04888"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601737" description="pectin lyase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="375" mass="39503" checksum="43ED25B4E5BB3314" modified="2016-11-02" version="1">MKSLLSALILSVGLAAPAAVAQVVGSPWGFATGVTGGGNAKPVYPTTNAELVALLGSAQPQVIVLTKTFQFVGTEGTTTAEDGCAPWGQAAGCQLAINANGWCGNRPRVRVTYDTAGTKPIYVKSNKTLVGQGSAGVISGKGLYLSGVSNVIIQNIEIVNLNPKFVWGGDALTFFGTDLVWIDHVRTSKIGRQHYVTGFGGNKRHTWSNNYLDGKSDFSASCDGRHYWGILVSGDGDEITFQNNYVQYTSGRSPALSGNSIFHAVNSVWSDNNGHALEGGSNARGLFEGCYFDRIKEVAGTNLQNKLFSASPSNRAQCQAALGRTCLPNGYRSSGTFPHSDASLLADFKGRRIAPAGSADEAFLNVPKNAGNGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL95</accession>
    <name>A0A1B7YL95_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161302.1">
        <property type="nucleotide sequence ID" value="XM_018300056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL95"/>
    <dbReference type="GeneID" id="28864163"/>
    <dbReference type="KEGG" id="chig:CH63R_05081"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05081"/>
    <dbReference type="OrthoDB" id="3497519at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="752" mass="84855" checksum="7C8774E469A10B1B" modified="2016-11-02" version="1">MLAVDCLWPLVVEGYSHDEKISSCFSVAATIIHELAADVVVIVVLDVHRPWLEEAAPRRGHAVNYAHIHWLYRPGPAADQVADFQKHPELEQKLVDIGESLFGKQDLKKLNPIEPYFENQQKSELGFATDGHVFGGSNWQTLSQSNLSFKHLNFLPSGSLMVRWPTGFNYSHGRMQTWEELKKSPAAMVLRTPPIVVDTYRVPVKVAEVARLFSEGFWRSEVVKFGTAALKLGTADPTRVRFLLDDPVPVTKRTGDISDICEKVMELYPDADKLAELGGIVWEFLDRLLLEYFLYPTVRFRWQKDYNNLYTRLGAIDLGAKQFSLAIKEVQILDQYLRCSARARRGGGNVAAQLDAWKTTTLQLYRAQIQKCRDSSSKVSFELPLGSDRLQNDATFWDRIGEVGTFAQRRFDGLLRTLYDLLSTEIDRIHEMYIDIYRLSPEERGRMRRRKCVQNLLGRLDILEKACRHTIVGHGGISALRLSFDVRPHFAQSFTVLMQRIKELVPWAHDVREINPANAHRLTPFIPNIRKARRPASARMVKLAQKEINLMSVEDLIAIEPFLLFVKHRLEAADAIEMDLTKDQKDHLELIVERMKAAYVPAAADDDGGDDDNSSEEGEPLTKIIRKRKNRGDDLASGQHVVRRRRIYVPRLSPPVLRHPRPLSSSTRPPHDHWRRRRSFGGIGSAARRGPSVASPSLQPPLPNPFASMPSITFPLANQGLSPAFSSQIVLGPFIGVAATAAAAIARFAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL97</accession>
    <name>A0A1B7YL97_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FtsJ-like methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_05113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161334.1">
        <property type="nucleotide sequence ID" value="XM_018300088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL97"/>
    <dbReference type="GeneID" id="28864195"/>
    <dbReference type="KEGG" id="chig:CH63R_05113"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05113"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="112"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="373" mass="41095" checksum="652FCAF9F304E3A6" modified="2016-11-02" version="1">MATVTLNKTASDQVSKAGEHPSDATTQMAIMSISEHGAKNPNQEHEAKKKVLVDYLREASPEFAKLDALRKKASDRFSDPGVLDMMKRIGKEMQKCTGALKVKTAGWGKPQILDMGMAPGGFLAVAMELNPGAHAMGFSLPEPAGGHKVMLPDDANIDRRDLDVTMLAEDLGFTEIPSNNPDAGRIVPRQFGANQQQFDLVICGGAVVRKQERASYREAYEAHRLSASQLALGLERLRPGGTMVVLFHKVEAWGTARELYAFDGFSRARLFKPTTGHNKRSSFYMVATDVQSRHPRALRAVARWKGIWEAATFRAEGELLKAMGSGEPGAEELLEEFGEQMVRRGRKVWKIQADALERAPFMKDKRDGSDKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM62</accession>
    <name>A0A1B7YM62_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161644.1">
        <property type="nucleotide sequence ID" value="XM_018296828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM62"/>
    <dbReference type="GeneID" id="28860935"/>
    <dbReference type="KEGG" id="chig:CH63R_01853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01853"/>
    <dbReference type="OrthoDB" id="4800057at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="828" mass="93222" checksum="65B09451C8CF2C6C" modified="2016-11-02" version="1">MHLDPGDGRRLTSQDEESYWQSVKMLQKEDDERMESDLVANTKYYMARLTDLNHQKQELERRALEVHRAISREHKSLEDLTNRFQEARMDLQLQRENHHRVVAAWFAEEHRKENDERARIAAAALAAPSHRHAASAETTQAIKAPNGIPSGIPSGIPNGIPNGIPNGIPNLPNGAMLNNGDHRNGPHPSIPVPGRPDQPPLTMIMDALGRSIGPVNRLLSSNRSVIFLSGLPQKRAVQLRPGVVLGQQDLKQLGEAEEKWMGAVIQATGLVRKQSQQCNMCARGQGPFAQCIGLDMPEFQACGNCMWQRTNCCEPLAAEQTPTITKFRAFNAPTQDPQGDRGPVNGNFNGSTTPASLSRPNSRDKSFLEGSTATDETEEDLTPITKATLTLKHDGTVYTHPECMEGVPVGKIDQDHPYWDQSWPEIAPTIEPTLQTWRDKLQAALEKGQNSMKFQLGRQVNRGETILKFLEDADFCPYQLVAKKYMMTRLVSYDTIFRLADTLRTLEGFKTLDITPLEWLRQRLQEIITAEGPSFNLAKTIHDFYHDSKYVALRLANGKKSIGRPSGMKMTPKDSPNSSKGTPNMKKRKLFISEEFPGASQRPLAPTPTTAHYPHPQPLLQSQSHVFHEEPQRSAPPTPELARPYKKFKMYQGPRKAKDPDLEYDGFTDIDEFSGDHIGNHDWALNRIKSRLNTASTGVTQYWHWIPDGGEEVFEHQVLAEGDNCTWGIYRKPINFHLELEHIQEMRWATETLKVIVVCKDGAVSSPTGEPRGNLMAEFKRDRTKRRFLDFCSKKGVALVKVEADVIEKAWDEYESLEVLAMGDSEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YM90</accession>
    <name>A0A1B7YM90_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_01886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161677.1">
        <property type="nucleotide sequence ID" value="XM_018296861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YM90"/>
    <dbReference type="GeneID" id="28860968"/>
    <dbReference type="KEGG" id="chig:CH63R_01886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01886"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="426"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="752"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="870"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115025" checksum="3B528D69E481957E" modified="2016-11-02" version="1">MSSLKRLLNEEDDELHYPDLSSMSPYGSVPPSYQGDQEYTGFHPRQTLFQSPDASQETPVLEDLDSMDDVFSNILFHYTAGPQLGAIDFGDEAEAPPFDFENALETWGRNTAAVSPEASSYTYSTPQPSPGASSQDSLRVTHSPSLIPESSVTGSDYYLSPRDDETDKVCYGMLYNVDVKLIGDMGVIDTKIRNTHHKESIRAPGRPVYQRFTLSEQQEHVLLAFRGSDGGGGSSSSNDDGDEATDFGYLRSGTGKTLGELLRGGGVGDDGLEFEPIAQTTALRDTIGRAKKPVEAMVKVDINVYGPRAAAAKVGGKLSDGKLWLQKPDHARAGFPYENPHVLAVRKSEHASGDATMTTVRQVRGDDGDPSSPSGRQPREERLRLMMMEVYDSIQKKRHLRREDGVQGLKHELQEFRHKITNIKQKSQPDERGGGILADEMGMGKSLSILSLVVTTLQNGQQWAQQEEQSKQKNQELCYSGSTLVVVSSALLIYEWKNEIAKHVQGNLNQIQYHGPKREKDIDKIKNSNIVVTTYNTLAAEYEKKSSILHKIGWYRVVLDEAHVIRRPATTFFHACRSLHANSRWCLTGTPIQNKLADIGALFAFIRAKPFDEPAMFRRYIEVPFEQNGDARKIKERLILLLDSLCLRRTKELLALPGLEERVKELAFTPAEREQYDKTKRILMRTIKQKVGEVEKSSKFGLFQANLQMRILCNHGTYQKPFSWSRRSHRLSRLEEREAAVSALGRNAEITCDGCHQPMPILGSSRLRNEAEEQCAHVLCSECLEESDMSAPGDPTRRRHCPVCENWMRTAARSQQAAASAAPAAASPLIRVDGPGGVSGDVEMVDAPAAKTSADKDDELYFNHIGYSTKMEALIRDVKEDVWTTKSIVFSCWTRTLHLVGMHLQRAGVRFDMIDGNCPLSERQKILEKFAKEDGVRVLIMTTGTGAFGLNLTCANRVFIVELQWNPSVENQAIARAIRFGQDQKVLVTRYVIKGTVEEEMRSQQNVKKSLAAIGFDEQVCDADEMDQSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YNI8</accession>
    <name>A0A1B7YNI8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162127.1">
        <property type="nucleotide sequence ID" value="XM_018297311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YNI8"/>
    <dbReference type="GeneID" id="28861418"/>
    <dbReference type="KEGG" id="chig:CH63R_02336"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02336"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="67" mass="7740" checksum="5E748E187A521166" modified="2016-11-02" version="1">MFVDQQKKQRREQRMEKAPVGLAPYGRATEGQEPRVRIIGQRFQDQNRMFIDNIIAASSLGYRGLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPS0</accession>
    <name>A0A1B7YPS0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_02678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162469.1">
        <property type="nucleotide sequence ID" value="XM_018297653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861760"/>
    <dbReference type="KEGG" id="chig:CH63R_02678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02678"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="13">
        <location>
            <begin position="4779"/>
            <end position="4985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4120"/>
            <end position="4695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="2671"/>
            <end position="2698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4123"/>
            <end position="4133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4172"/>
            <end position="4190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4197"/>
            <end position="4228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4246"/>
            <end position="4260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="4263"/>
            <end position="4272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4285"/>
            <end position="4303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4304"/>
            <end position="4314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4318"/>
            <end position="4349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4350"/>
            <end position="4360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4375"/>
            <end position="4386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4387"/>
            <end position="4418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4425"/>
            <end position="4436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4513"/>
            <end position="4568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4620"/>
            <end position="4646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="4661"/>
            <end position="4679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR13952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="4994" mass="557162" checksum="1FD2614DD0A85469" modified="2016-11-02" version="1">[encoded data, 4994 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ07</accession>
    <name>A0A1B7YQ07_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018297830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQ07"/>
    <dbReference type="GeneID" id="28861937"/>
    <dbReference type="KEGG" id="chig:CH63R_02855"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02855"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
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            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="314"/>
        </location>
    </feature>
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        <location>
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            <end position="324"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="689" mass="74683" checksum="46F449CCF376FC82" modified="2016-11-02" version="1">MDFLRSHSKTRKGRSRFSKALPTPPPPDQDPPPKSKQLPSIPPVPPVPSKKAFFAMSDKPLPSPRSVNDQSLPPQQPPPPHALPLPLPPLETKALPPVHIARRPVAKQPPPPPPPPQVSQPPSTSPDDERNSIGSLLSAYSRSSGEYIIMSPDGSASQTDSAPAYASDHQYGGKTLTPSSLSSGENTSNSSNNNEHNGAPNFTANKGLPPHPAYYTEQGSPAPPAKLERAPTVGSPTSYVSSTSPQQQQQRPLWRRRSVRSERNIEVSNLQLAVSHGSTAASQPNTAQTAPPSAALPPTPAQQQQQQQPQNQQQFPLRSTSNLPGRNVRPVPSQPQPAEAADTMGQEASRLKTKISHLRDGHHHQGAANPGISHSDTALSPTQRLPTPDYEKEDVKTQQHVVDRILVSPVSPASSPEPAGVRDQAGAESKPSLPRKAVTARNLHAAHSLPQMRVDGPVTSSEAPPTITKDFAVSPVSPGPQSQLPHRAAPQQQQQQKQQQQRSQWQQPPREYTPYAPAPGPAQGDLRSPTRDQRPPPPSAQEPVEYRELKTANLPPADPRASYFPTQGSEPPSPGIVYKALPLKESMLDCYVRHRVMDRTRNRNYALTCQTCGRADTEDRFKCQFCYVRMCAACLHIFNGHRRDLRKLVAHLEGNPHSGGQPGGAAAGAGNEPAEEQRQHVAEKTTEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ77</accession>
    <name>A0A1B7YQ77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162708.1">
        <property type="nucleotide sequence ID" value="XM_018297892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861999"/>
    <dbReference type="KEGG" id="chig:CH63R_02917"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02917"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="622"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1336"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
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            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="315"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
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            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1434"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1495"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1617" mass="177279" checksum="A6575ACCB6E34629" modified="2016-11-02" version="1">MPSKRKREIEDFDPNKSDSDDENFEPGADAPAVRSKKRSRGPKIQRSAGGRRRANRYNGSDIEDDDDEDVSDSQDEGSFVSEEEEDEEVNAPVNAAGRRARKAATKHNSYKESDDEESEDAEESDDVLSEDLPKPKKKDSLLIKLKVPKTASTPAPAAPATRRSTRARTEELGEEHVELTNSGKHSRPASRSRSPEAFARTRSSRSIKGLKKGPETIEEATQESSGPRVDDADVDELAGDVEEAIAEIKDTEMEDVKESTEQAPAVDVVVDEDDEEDEGPITRRTRAKRGSGSAAGTAEPDADAKRGAEDDGPKRRLTRRNGLRKSKSVQEPSSDFEPGEESAEEEAHMSESPKKDSGDGDDGDFDSPAPRGRAAAKPKGRSTRSSRRGAESAEEVELDQDELAEELHELRQDSRSRRTRRPSPAIIYQETASKRRRAAAKPMNYFMPPLSAVNLEEDAEDPAPTPARRRGGRGGATQSWDRALNTTFGPFGGGGGAGSLLTGPWGAGAAGGVDSDSSDDEMGQRSGAAGNVGMTPTSAAAPAGLLPGLAQPLGGDAGVGATPNVGKIKNQKALADADPLGVDLTVDFNHVGGLQGHIDQLKEMVQLPLLYPELFQKFHVTPPRGVLFHGPPGTGKTLLARALANSVGIGGRKITFYMRKGADALSKWVGEAEKQLRLLFEEARRTQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVIVIGATNRPDNIDPALRRPGRFDREFYFPLPDVAGRKSILEIHTKDWGLSEPFKQQLAENTKGYGGADLRALCTEAALNAIQRTYPQVYSSKDKLIVNPDNISIHATDFMLSIKKMIPSSERSAGTGAAPLPKGVEPLLRDQFGSIKKALDEVLPRKKKLTALEEAMYEQFDDEDQGFGREALHQEFERSRIFRPRFLIHGFSGMGQSYLSSALLHYFEGVQVQNFGLPNLLGDGRPMEQVIVSLFTEVKRHKPSVIYIPSIDSWYAAMKDTLPFITFKAMLKSIPPTDPILVLATAEYEPGEGLAPDLVRELFSFSRKNRLQIERPMHSNRREYFAAIVEHIRKSPADFPDPANRKKRVLEQLPVAPPPPPKVPTKEEVKAMQKRDHQLLNILKVQLQPIMDQINRKYKKFRQPVITPAQLEYLFLEMDPNYVRPDIVGAEDRPFEIVKDKYGDDVLRETATGKTFYNLETTTIEERLSNGFYCRPKDFLRDIKSLAKDSKNIGDKERTLKANELVSNVEVDVATIEGNTSTVDWEALHQRQLQRAKAAAEKERKRKALQSVVDRMQTDVAGGNDSDSQGPVTLGERIPGSAHAMARFQVMSPAPGDTAETQQPSNGGPEPSRLSDVQMSGVDDDTTQDSSMQPPSQWPQQANLTTGATTGTTQVSQRSVITTVPPGMSPSAIVNDASTTKTSDPSERSTDKWSTQATNGFHPDQSSQGDTSQLQDTQIPAGMGGVSQATSSDDPWPHSQAHGMARGVIRPPGSQTSSPNKSRSSGDSKHAMPLVNILNESTSDDIRNSGSSSSQQQPVIHEGQVTQFLDELTERTSGCTIEQLEQINRELMDEIWNTRHEWNRMKVLSDLTNVFNETISDIESIQGLFQQSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQW1</accession>
    <name>A0A1B7YQW1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162861.1">
        <property type="nucleotide sequence ID" value="XM_018298045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQW1"/>
    <dbReference type="GeneID" id="28862152"/>
    <dbReference type="KEGG" id="chig:CH63R_03070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03070"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="198" mass="21244" checksum="C23597551D71B106" modified="2016-11-02" version="1">MQSFLQHRRAGVEAQAQIDRDIGKTQSFNAPSRTHNEVQEQPLAEKKQKSPSSSESPDTIDTEAPGQRPDRAPGLLERSQTARTECSEGTALGRVLTGIHVRDRTGDEGHGGRVFVVGWAGPDDPLDPHNWPTAKRIGVTLQISVIALFVGAASGIDATVLPQAARAFGVSEVAESLATGTSLPPLHVIRRSTQVHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQZ6</accession>
    <name>A0A1B7YQZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162899.1">
        <property type="nucleotide sequence ID" value="XM_018298083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQZ6"/>
    <dbReference type="GeneID" id="28862190"/>
    <dbReference type="KEGG" id="chig:CH63R_03108"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03108"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="90" mass="10295" checksum="4A0C0AA75EC89EE3" modified="2016-11-02" version="1">MNARAGLTCSRPIVLARRDSITMNTNHHRQPRRKRGPQFLTHCFLALVVMIGFGHGCEHNYEGLFSKSSNPIRTAGLIDTQKWKWFSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRQ4</accession>
    <name>A0A1B7YRQ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163151.1">
        <property type="nucleotide sequence ID" value="XM_018298335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRQ4"/>
    <dbReference type="GeneID" id="28862442"/>
    <dbReference type="KEGG" id="chig:CH63R_03360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03360"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="68"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="63433" checksum="E1E43A906ED2EA79" modified="2016-11-02" version="1">MSSTGVERAGGLPSYGYSNHGRFPDEKLVGDEKVLGGQYGEPLESGFRSSLDSGGTQDHTHRKLKSRHIQLIGIGGTIGTALYVQIGRGLINGGPASLFLAFSIWCTFILAVTLSMAEMVTYLPISSPFIRFAGRYVDEAFGFAAGWNFFVFEAALVPFEVVACNLIIHFWSDVVPAGAIIAIILVLYGVINVMAVQWYGETEFWAALGKFLLIIGLIIFTFIVMLGGNPLGDRFGFRYWYEPGAFNELYYDGSLGKFLGFLQCLILASFTIAGPDYVSMAAGEAENPRKIMPRAFNAVFYRLTAFFVLGSLCVGILVPYNDDELTRAFKDGQPGASASPYVVAMNRLKIGVLPHIVNAMVLTAAFSAGNSYVYCASRSLYGLALEGKAPAFLKRCTKNGVPVYCVIAVLLIGLLSFLQLSANTAVVLDWFVSLVTASQLINFACMCTAYLGFYRALKAQGISRDSLPYKGWFQPYAAWYGLVGTFIMTFVGGYTVFLPLDGYWNIPDFLFSYTMVGIFPVLYFGWKILKRTKIFKPEEVDLYRDKDEIDEYERTFVPTPPANMFERILDKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSS4</accession>
    <name>A0A1B7YSS4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163529.1">
        <property type="nucleotide sequence ID" value="XM_018295167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSS4"/>
    <dbReference type="GeneID" id="28859274"/>
    <dbReference type="KEGG" id="chig:CH63R_00192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00192"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="132"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="574" mass="61777" checksum="51057C865B5C919C" modified="2016-11-02" version="1">MAQTRNSADDGRGNTSTDVVGDRDMVAAPAAAAATAGPDEAETEKVAVVGEASSPQVSALNSTPDGSGVERRGGNVWAGDETRSPTPSPSNSDCESYRGGKGRDGVVDLVVKTLTWTPRKLRYDPENPPQFTLALNFMFAVAATFTVANLYYNQPVLNRIAETFEVSFERASSVATLMQAGYAAGLLLICPLGDMVRRRPFILGLIWVTAMLWLGLCVTNSFEAFLGLSFIVGATTVTPQLMLPLVADMAPAHRKASSLSITTSGLMLGMLIARLLSGIVANYTSWRTIYWVSFGAQYAILILLFFFLPDYPSKNPDGLNYFRALWTIVTMLFTEPVLVQACLIGFFISAIFTSFWTTLTFLLASPPYEYSSITIGLFSLIGIAAICGGPVYGRLIMDRYVPFLSSVLGQVVIFVGCVVGAFTGEFTVAGPVVQAICIDMGIQTAQTANRTSIYTINAKARNRVNTAYMVCVFCGQLTGTAVGNRLYAQGGWKYSGGASVGFIGLSIIITMLKGPRETRWVGWSGGHKLRRDDVAKKPEPVSPEDGRGTMRAEGEEETTGEKRPETGADHSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTL4</accession>
    <name>A0A1B7YTL4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163906.1">
        <property type="nucleotide sequence ID" value="XM_018295544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTL4"/>
    <dbReference type="GeneID" id="28859651"/>
    <dbReference type="KEGG" id="chig:CH63R_00569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00569"/>
    <dbReference type="OrthoDB" id="4840992at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="45195" checksum="F9ECE3EDC0675D26" modified="2016-11-02" version="1">MDHNDQEHREQPNETERKQRHPACDNVSSHQNRRFHGSIHTSSEPSLLLDTLDTRILDPVTYDNVRAHLPNRNAHGRRRFATTRDQPDVAQWAVFDRHESITLWADEWGRFWEKGSKGPAQRSDMVLVPIWWRRTGSYTDAYIKESARYVLYWTPDGNLRIRQSLREGISASTHYFFGYFPRRGHTDLWFAPMSAPSFSRVFWFNGEIAAPESLIHTRPQSASERDTRHDCIRHAVRQGLDSNRDLGTEDCQLERGRAEPTRPLSEKIKSLLSLIETARLEFRQLVEREVADFKLNVGERDTKRTHPGAGQRLTNIPGSRGSVLSTRDVSVRLRANDTTQLCKHQVLRERTKNGLVDSRNCNELATELHLVQCHVRPSVSVVTDEHAEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTZ8</accession>
    <name>A0A1B7YTZ8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_00681</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164018.1">
        <property type="nucleotide sequence ID" value="XM_018295656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTZ8"/>
    <dbReference type="GeneID" id="28859763"/>
    <dbReference type="KEGG" id="chig:CH63R_00681"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00681"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="293"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR15501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="51845" checksum="6598B209211C30D0" modified="2016-11-02" version="1">MADQSIIRITKELSDIQRTSDLSLAVACRDVDVRNVKALIIGPHDTPYEFGFFEFAIRFNKEYPRKSPSVNGITTNGGRCRFNPNIYSSGKVCLSILGTWRGERGEEWSAAQGLESILISIQSLMSGNPYENEPGFEEANDASDKKNQKDYVQKIRHETLRISVIQRMEEYLGLTPNGNAIAQQSAADGEQLEMDTEDMDDTNVPFEPFKDLCKRRFLWYYDNYLLAIQKAKTEVKDHQAFVRMPFEGASNAMDGKFNYTELERRLRNVKAALDNELLKWAVEGQVANEKEMTVSVNLRHQYQQVVQTFKRQDIPHDVQLEDNNPFVWVITYFGRPMTNLDGGLFRIKVHFSPRFPEEQPRVKFHTRIFHHRISEDGTTCYFPSSLRKDDVRSHIEAIFTALEEEDPAYDPRTLVNPEAHKLYWGGADGRKNYNRRLRRSVQQSMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YU45</accession>
    <name>A0A1B7YU45_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein RCR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164092.1">
        <property type="nucleotide sequence ID" value="XM_018295730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YU45"/>
    <dbReference type="GeneID" id="28859837"/>
    <dbReference type="KEGG" id="chig:CH63R_00755"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00755"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18042" checksum="6094A03D6906304A" modified="2016-11-02" version="1">MAAFEFPQSLDKRNGACYQRGAWYWWGRWVLAAVVVGITLIFLLMCMNARRRKRRGVQPLYGTGWMGGNKHNQQGTYAYNQQYNGQQQGYAGYPQQGADGSYPAPPPAYGQAQQHPQYTGTTFNPNDGYYGGHNEGIQLQQPQNSYQRDVYSPPAGPPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUG7</accession>
    <name>A0A1B7YUG7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164180.1">
        <property type="nucleotide sequence ID" value="XM_018295818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUG7"/>
    <dbReference type="GeneID" id="28859925"/>
    <dbReference type="KEGG" id="chig:CH63R_00843"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00843"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="112" mass="12894" checksum="8D2682875C908752" modified="2016-11-02" version="1">MSAQVANQRKQQDLQTQYGIYKNTLQQIAQKIGDVEQEAEEHKLVLETLQPLSDDRKCFRLINGVLMEQTVKDVMPALTTNSEGLKKVLEDLVKQYKAKQEELEKWKVSDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUT2</accession>
    <name>A0A1B7YUT2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164211.1">
        <property type="nucleotide sequence ID" value="XM_018295849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUT2"/>
    <dbReference type="GeneID" id="28859956"/>
    <dbReference type="KEGG" id="chig:CH63R_00874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00874"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012678396" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="74" mass="7966" checksum="48EFED7F959E8406" modified="2016-11-02" version="1">MYNFHILLLASLAAASVMVRDTPQPNNSPVTPPDNVGSPKQGNANIGLNPDYTYVVFKRDAEAANGDDVSDVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUU0</accession>
    <name>A0A1B7YUU0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polymerase/histidinol phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164327.1">
        <property type="nucleotide sequence ID" value="XM_018295965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUU0"/>
    <dbReference type="GeneID" id="28860072"/>
    <dbReference type="KEGG" id="chig:CH63R_00990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00990"/>
    <dbReference type="OrthoDB" id="4652505at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="89564" checksum="03F92DE911A1EE79" modified="2016-11-02" version="1">MKTLSDDELRGLTGQYFAPKGLYQYTKSLPFLGDLKCDTSTLVAGQWTEIITEYTIGASGLADGAWIKGTFKFYSDWALFQTSDPRQDNYVSAEYIPGPLHDGQTPATVQSLAVRFDQKGHERPFQKAIIIDIVDGYMNPGDRITVRIGDRRWGSRGTRVQTFVEDEFLMRWYIDPVGTSRFAPIKPDIAFSIRPGPVARVKAITPRLVRADVAFPIHIHTEDVWGNATADLDGLESRVTVKKEDSSDAVWERRLSLPSQGWTVANDTVTLDSDGDYVLSVTIFNHEGSVIETQEYISVESSIPIPRPLYADLHVHSDDTVGTKSTTYNFSYAQQIAGLDVVGYTANDFNITKERWEKTLEIIKRVNSQGEFVVFPGTEWCGNSAAGGDHNVVFLDDPETSRPEFPFDKNGNVARSFEWNEDGPAELLPGAWPLDEVYATYAHSPEAHLLIPHVGGRRCNLAWHHPQLERLLEIGSAWGLFEWLLRDAVTRGWELGVSANSDEHRGRCGGGVPGTAVFGTKGGLTGVLADKLERGEVAKALRGRRTFATTGERLVGLVSTGNGELQGDDVTVKLGESVALTYRFYGSGGFSSVEAWDASGRIFHRDLQQEASEHADGSTLRKIRVKWGGARVYDRYREAVWQGSILVPGAVVTHVQSFGGVSDNGEDVVKRVSDSQVIFDTRTSGDFDGVDIFLAENSGVPSTIRVSGHLGGYVKVGDVLKGNPHKPQPQFDLVVSNEEAVRPGGRKEDIHGGAELFISVESLLDVPLPRRVEGRFPVTGGSPTTGHSRAVYFVGREHSGGKVITSPMFMKNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWC0</accession>
    <name>A0A1B7YWC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW/HypB/UreG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164858.1">
        <property type="nucleotide sequence ID" value="XM_018296496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWC0"/>
    <dbReference type="GeneID" id="28860603"/>
    <dbReference type="KEGG" id="chig:CH63R_01521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01521"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="340"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="586" mass="65396" checksum="7B2F35C3B4526B11" modified="2016-11-02" version="1">MGKKLTGSSAKSKSGGVVVPANTAQKPSNAPPKLTRSDSGVDVTKDAEAKPLPVTLLSGFLGSGKTTLLQHILKSDHGLRIAVIVNDIGAVNVDASLIKKSHRLTKTEEKVIALQNGCICCTLRGDLLEELVNLSELHEFDYVIIESSGISEPEQVAETFDARLAEQMAALGEGPEGLDENTMKLLKRLADAGGVDKFARLDTTVTVIDAFTIFNDFHTSDLLSSRRDDVVPEDERTVSDLMVDQIEFADVIVLNKIDMVSKADRARVLDLIKKLNPRAKVLEASYSKIDVKEIVNTNTFDLKVAQSGVGWLQDLHAMTVREVNGRKAITPKPETEEYNVRNFVYTRTRPFHPRRLWSLLYDKFILQMEAPEDDEDAMDEDEDDADMSDADGSDEEADDDDDDDEEEEEENDDEDDDMEDPLEPPENDVILANKTAHPLFNRLFRSKGEFFLATRPHRAGDWSQAGAMLTMTGGRPWFCTLPPEDYLTGDAEVDALVAHDVDKGGEWGDRRQELVFIGENLDVGGLEAALDACLLDDAEWKRWGKVMRNERWDDEKKRDRLQDLFDDGFPDWAEEDHGDHEGHDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVA3</accession>
    <name>H1UVA3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase K/M:Cysteine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04391</name>
        <name evidence="3" type="ORF">CH63R_03712</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000265">
        <property type="protein sequence ID" value="CCF31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159933.1">
        <property type="nucleotide sequence ID" value="XM_018298687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVA3"/>
    <dbReference type="STRING" id="759273.H1UVA3"/>
    <dbReference type="GeneID" id="28862794"/>
    <dbReference type="KEGG" id="chig:CH63R_03712"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03712"/>
    <dbReference type="eggNOG" id="KOG1481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039949_1_0_1"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000058">
        <property type="entry name" value="Cysteine synthase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="396"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="532" mass="59008" checksum="FB783250F99C2A4A" modified="2012-03-21" version="1">MAEPNHLNVYTGPNSVKNYFDPDTAPPLPLVEIPDCLNPYRKHGVRVYAKMMSMHPANNVKAMPALNLLQNGVVPGKTKTVVEYSSGSTVISMSLASRVYHDVPDVRAYLSNKTSQAKLKLMQFFGLDITLFGGPSQPEPLDQRGGIYAAKNMGSDKGAALNPNQYENDDNWKSHVRWTGPQIFKQLPQITLICAGMGTSGTLTGLGTYFKSAKPSVYRLGVCTAPGDRVPGPRSYALLQPVEFPWRAAVDHVEHVGSHESYALSLELCRQGLIAGPSSGFNLQGLYQFLDKRLEAGNLKELADEAGEVHCVFICCDLPYQYIDEYFAKLGPEHFPAIHNENLQKVDLHRYDEAWEKDPAEIFLQIPHTSIVRTEDVQLPSTPRYIDTSSASLIPRLPNVAIIDLRKPEDFQTHHIPGSENIPVVDSSDWKPFSDAKILEKVWLKLEATLDPKTETGKILEEYRQKPIVVLCYDGDSSRVATSVLRARGFEADSVRGGFRALRDFQRTPEASFTMVPKSLAVASSVEELVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW66</accession>
    <name>H1UW66_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04642</name>
        <name evidence="9" type="ORF">CH63R_06775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000356">
        <property type="protein sequence ID" value="CCF32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159600.1">
        <property type="nucleotide sequence ID" value="XM_018301750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UW66"/>
    <dbReference type="STRING" id="759273.H1UW66"/>
    <dbReference type="GeneID" id="28865857"/>
    <dbReference type="KEGG" id="chig:CH63R_06775"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06775"/>
    <dbReference type="eggNOG" id="KOG4841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150782_1_0_1"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="94" mass="10567" checksum="346BD8DB5F12B6D5" modified="2012-03-21" version="1">MTRAQQTVSLALLVSSLYLALYLQLVPIPAKIQDEIVPVLPFWVLISFGSYLLARLGYNVMTFNDVPEAHKELMAEIDEAVVDLRKLGVDVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW79</accession>
    <name>H1UW79_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04650</name>
        <name evidence="3" type="ORF">CH63R_12036</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000360">
        <property type="protein sequence ID" value="CCF32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
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        <property type="entry name" value="PGP-like_dom2"/>
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        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
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        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
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    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF32230.1"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="239" mass="26288" checksum="241584638180C124" modified="2012-03-21" version="1">MATPKNVVFDVVGTLVTYEHLFEAIDERLGEKLRARGIQPKLLGCCWLEVAEREYTYLSMSGRYVVFYKVFSSLFYRCLHYAGVEEPRAFASDEDVDYLIGEWKKLQLREGAAECIGKLRDAGFTVWCFTAGDIARVGGYFSRGGVDMPVENLLSCDSAGLAKPTPEAYTPILKKLSAGGSTPWFAAAHLWDASTAKTVGFKAAYCSALEGEALPDIFGEMDVVAETLPAMADRIIATF</sequence>
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    <accession>H1UWU5</accession>
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        <name evidence="2" type="ORF">CH63R_12215</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000427">
        <property type="protein sequence ID" value="CCF32446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018307189.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UWU5"/>
    <dbReference type="STRING" id="759273.H1UWU5"/>
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        <source>
            <dbReference type="EMBL" id="CCF32446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="301" mass="32739" checksum="AAA5777910730EC2" modified="2012-03-21" version="1">MKRWINLNRLVLALVLYGPLIWAAADTNIKSIFLFKDVLQSNTTALKTSGFNSLVIFRIGVLADGDLVYYSTGDAGEAVDAPVVTNGTYVGGVALADKIRSFKTGPTNIDRVEVSLVSHDATFQNIRDLVNADGTGPETVLHRNFDALKTEWDLDAFNNDDEGVYDVPSTVAFARLLGVLGYQYSIAPYTNIEFWADVKGRVDADAPGLLDRVYLQVYDGGAGNDPGQWQAALGIPVVPLVWVVNDAKPSQGVTAARARERFEGWSEQYGVAGGGYWNDYDIEKMGSSYVEYAAALTDVFG</sequence>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Stolte C."/>
                <person name="Sykes S."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
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                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Kubo Y."/>
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                <person name="Lebrun M.-H."/>
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                <person name="Zhou S."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
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                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
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                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
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                <person name="Torres M.F."/>
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                <person name="Buiate E.A."/>
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                <person name="Alvarado-Balderrama L."/>
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                <person name="Birren B.W."/>
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                <person name="Choi J."/>
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                <person name="Zambounis A."/>
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                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
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                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
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                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
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                <person name="Lee Y.-H."/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="291" mass="30333" checksum="02868FE7B4983CA9" modified="2012-03-21" version="1">MKTTTFLCAVLASTAIAQPHQHANKRRHVHGKHQKRALVTEWVTETAYVTEWVDSTTTVWVDPDVSSTSSAVPTTSVPAQFFEPANQPVYNTLSTSTKPSPVASPVKEPVSQAPPPVPTTSTSTSAPAPAPQTPTPELVQPSTPVYVAPPPVPTTSSAPAPAPQPTTEAASPSATPTSPSGGSGGSGGDVHSGDLTYYAVGLGACGEDDSGKDRTENIVAISHLVMGAQSNGNPYCGRKVKISVNGKTTTATVRDKCMGCKAEDIDVSEKCFLEMFDSLGVGRQTVEWSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZG3</accession>
    <name>H1UZG3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_05568</name>
        <name evidence="3" type="ORF">CH63R_02516</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000728">
        <property type="protein sequence ID" value="CCF33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162307.1">
        <property type="nucleotide sequence ID" value="XM_018297491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZG3"/>
    <dbReference type="STRING" id="759273.H1UZG3"/>
    <dbReference type="GeneID" id="28861598"/>
    <dbReference type="KEGG" id="chig:CH63R_02516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02516"/>
    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_341311_0_0_1"/>
    <dbReference type="OrthoDB" id="3439935at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="822" mass="87869" checksum="8715D9E915D8CB09" modified="2012-03-21" version="1">MTRKTRSSTICEWALGVSVEEYCNSVDRRRSKKSSGRQRICVEISTDDESEEDTVKITYPRANRSKSSNDHSPGIKKVRFDKVVPKSALKSPEEDKNKSFKTDVSFESEPESKSKKTKKSDKSVKKKKKIVDPSSESEDSETETTEAEEAEEETVPPPKKKKEEAVDTSKKQDKSKDTRKPSKKSKESTISADVETNNVGPATKKSQEKSKTTKEKSSKAEVHQKLRPEAALSPHLRRPNLIMPIRAEVLQVEHAIEGVEDPRPNAFHDSQHGVVRVYHGPAYGNPYGMLYPARDPNKASLPMGVPHPLQNPYFHGFASPRNPGDNYFKGQSHWSAVPITNMPGGPPVMAPVDPMQMQMQMSPPWWGLMSPTKAASPKGSPKPVMSGAIQDDGASTGARNKDKGWDTNVGPQQNKAPSPAKQASPSNIAPAPAPVSPININLTVNPNTPWAAFASDISKKSTPKTTGSQVNGGGSNGSKKSWGSKKPTDWQPIASGQHPDLGWNTPRKGQRSNNGSKNGSNSAWVQTGGPSNDSWGVTGGNGNDNGWNNSGNSQNNDTQPTSGGDGWTTTNETTWGDSSNNQAATMINDEWGASNDQSGDVWANGGGNTNWSTGSNHSGSKKSSKGQNGSGSNRSTSGRVQQDTNWDSQFNNVGYSGRVVSNGSNKPNKSKKKTPPPSTNGGWDNNAGPTTNSPVGNSNRSNGSKNSPNKASNNGDTWVTEDDSAWATNNNAGPTNNNSPNVSQRSKQNSNSGSKGGDQWVAAGGGAGWGPETTSGDNWNPTATDVSKTSNSSKSMPGAWDNTLPWADTSMAQSTGGAADNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZQ7</accession>
    <name>H1UZQ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UreD urease accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05647</name>
        <name evidence="4" type="ORF">CH63R_04454</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000769">
        <property type="protein sequence ID" value="CCF33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160675.1">
        <property type="nucleotide sequence ID" value="XM_018299429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UZQ7"/>
    <dbReference type="STRING" id="759273.H1UZQ7"/>
    <dbReference type="GeneID" id="28863536"/>
    <dbReference type="KEGG" id="chig:CH63R_04454"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04454"/>
    <dbReference type="eggNOG" id="ENOG502QSQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021703_2_0_1"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="329" mass="35790" checksum="147D216AA77C8535" modified="2012-03-21" version="1">MNSPFPKSSSVAGEGEIVAQLLPNGLSGLKAMSYQYPLKLISPTPAADQKSVLVFLLSYGGGLVGGDSVNLSIRALSGSKLSVVTQGHTKIFKSASPDIVTRQTLEVHIEDNAGICQLPDPVQPFDGSVYEQMQIFTAAPSASLCLLDWVTQGRTARGEDWSFIKWTGRNEVWSSGERPQGKNRLLVRDTVTLDRNSQGLVGRSLRDSMHGNGLFGTLILRGPQMHALGNFFLDEFGVLPRLGARDFRSAEAKATEENNSTEDELWRAKRIEMEAKDGILWSAARVRGCVIVKFGASTVEAGRLWIGNMLSREGSVAALYGEQSLMCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0J4</accession>
    <name>H1V0J4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_01025</name>
        <name evidence="12" type="ORF">CH63R_06110</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CACQ02000879">
        <property type="protein sequence ID" value="CCF33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158935.1">
        <property type="nucleotide sequence ID" value="XM_018301085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0J4"/>
    <dbReference type="GeneID" id="28865192"/>
    <dbReference type="KEGG" id="chig:CH63R_06110"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06110"/>
    <dbReference type="eggNOG" id="ENOG502SA4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111658_0_1_1"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555442" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="191" mass="19415" checksum="1288132DFB37B868" modified="2012-03-21" version="1">MVCLKPALVFALCAVSAAANPIAALDKRQAAVDVGTANIGTVTCGDNRYSKKQIEEATAEGCRLHAANQQLGSSQYPHRFNNRENLAFASSGPYQEFPIISSGNYTGRSPGPDRIVFDPDYRSGCVYVGTMTHTGASGRNGFVSCNQTKSSSSGGGGSGSSSNGTSAASALSGPTSLGAAVSILSLLALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V168</accession>
    <name>H1V168_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_06057</name>
        <name evidence="4" type="ORF">CH63R_12148</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
        </source>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12148"/>
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    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
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        <property type="entry name" value="formyl-coa transferase, domain 3"/>
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        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF33970.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR05445.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="393" mass="42481" checksum="405E9EBE236C8477" modified="2012-03-21" version="1">MATSNAPKSSAREPLPLEGITVVSLEHAIAAPFCTRQLADMGARVIKVERPGVGDFARAYDTRVNGMASHFVWANRSKESLALDLKKPRDFEVLKRLLAKSDVLVQNLAPGATERLGLGYNTLRETHPSLIVCDISGYGSDGPYRDKKAYDLLVQSEAGFLSVTGNGPEPAKAGISIADISAGMYAYSNILAAIIKRGKTGRGARIDISMLESMVEWMSFPMYYTHNDAPGLARSGAAHASIYPYGPFETGGGGSVMFGVQNEREWTNLCRDVLGDEALARDPRFVSNTLRVRHRDELKAVICGVFARSSAEEVLAKLDGAAIANANVNDMQGVWNHPQLKARARWTDVETPAGKIPALIPPGFASVEESRMGKVPGLGEHNEAIFRELGVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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    <name>H1V594_COLHI</name>
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        <name evidence="4" type="ORF">CH63R_13595</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001521">
        <property type="protein sequence ID" value="CCF35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150887.1">
        <property type="nucleotide sequence ID" value="XM_018308569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V594"/>
    <dbReference type="GeneID" id="28872676"/>
    <dbReference type="KEGG" id="chig:CH63R_13595"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13595"/>
    <dbReference type="eggNOG" id="ENOG502SY4G">
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    <dbReference type="HOGENOM" id="CLU_686986_0_0_1"/>
    <dbReference type="OrthoDB" id="4148767at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 10"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="401" mass="45787" checksum="1D8F2FB96699F39D" modified="2012-03-21" version="1">MTAEVPNSLNWVSFITGILSFGLTVLNLIALYANFVTTIRSAPTDIRDSLGNLRQQLCEEREALRHQTKEIRAHGKLRHRIVNIGGKLANREARRALSYAEQTLPLHYITLRDLWRTFKDIERPFLVASGHRAEAIHNGAAWVEGDLDEKVRTDFERHGESGSFADWSALYKCDFAHRFIWWQVKDDVRRLSDEVGRIMARRTEREVTYIRIMVKQIFQSDGPPQIIDVHPRRPPGGGGGGGAARRRTSWAQGPVRRSPAPVRSPVSARKSPVPMQSPHCDWCARHAEEGSSSSESSDTDNRKRRRAMDVPRRRDGSPGESQHGRPRSDAATVGKQQHRPRPQQQTSRNRWEQFRSRPARQYDIREYFEGRGQDHSRIVEVIPGSEIDYFSPHTQREGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6Y4</accession>
    <name>H1V6Y4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_07656</name>
        <name evidence="5" type="ORF">CH63R_00647</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001783">
        <property type="protein sequence ID" value="CCF35986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163984.1">
        <property type="nucleotide sequence ID" value="XM_018295622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6Y4"/>
    <dbReference type="STRING" id="759273.H1V6Y4"/>
    <dbReference type="GeneID" id="28859729"/>
    <dbReference type="KEGG" id="chig:CH63R_00647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00647"/>
    <dbReference type="eggNOG" id="ENOG502QSNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024518_2_1_1"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF35986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="470" mass="52905" checksum="8671F563103E0C4F" modified="2012-03-21" version="1">MASRVIGAAKLLSKRSHVIPGKLLVSELFFEVPKDYSNQSSGVLQLFGRSVTKHERPVVPPSETEKKQAEQKPWLVFLQGGPGFGNPEPQDSPVTHTALERGYQVLFLDYRGVGLSSPVSAATLALQGNAEKQADHLKLLRQDNIVNDLEAVRACLTSDFPEEKKKWSLFGQSFGGFVSLTYLSRFPQGLREVFLTGGLAPVGKIPEQVYEATFKKVMERNKAYYEKYPEDIESVHRVARFIQEKKRVNLPGGGFMTVPRLLTLGIAFGAHGGLDSVHSNILKLKTDLDQFGFFTRASLADFEQATSFDSNIIYAILHEAIYTEKPGVASNWAAYRVGKALEEFSWLENEPAISEYTAAPLYFSGEMIFPLHFETYPELVELREAAEILAKFDEWPELYDQEQLRKNTVPVYAAGYIDDMYVDYNFAKETAALVKGTKVYETNQLYHSALRGRTADVMRELFRLRDDPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1V804</accession>
    <name>H1V804_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07942</name>
        <name evidence="4" type="ORF">CH63R_14081</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001941">
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        <property type="protein sequence ID" value="OBR02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018309055.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V804"/>
    <dbReference type="STRING" id="759273.H1V804"/>
    <dbReference type="GeneID" id="28873162"/>
    <dbReference type="KEGG" id="chig:CH63R_14081"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14081"/>
    <dbReference type="eggNOG" id="ENOG502S320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055147_0_0_1"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="274"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
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            <begin position="312"/>
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            <begin position="350"/>
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        </location>
    </feature>
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            <begin position="375"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36356.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="439" mass="48927" checksum="06A32A29532D8287" modified="2012-03-21" version="1">MASPTSDDKNGFDQEAVGLPDYQIPPPDLTLLQRLTFRRPERYTDNMKKMLGAVAGGIGRQPTQDEVNVLCHIAYKEAQTVAWVVPLSAVLGATLTWIGRRTYRFPFFQPKFVKFNPDLFPTAKAPFVQGRLANRLWHNTRFVAYFALSSILIAPFMGSYATAVAMATAQRDERLAQFRKDMKPERLVLTTAAKLPSIELDRQRQRTVSAIQALERELAKFPTEDQVALKAGPENADKEVQGLQQAIALLQGKIAEYRRILDHLDELIEKRRKGGVDGASAQNQDYETLSGSGFADGYTLPTQLNNVPPLDSSRDPEERRGWGSKNSTFRQSSSASDDPDFDDASPSAPNTPNTGLQSSTQSSKTGSAWDRLRQASRQPPRTPGGSQNQQSESDAYYAYDAVDKEKTAEKDKAQAEFDAMIERERKGDAGRSNERNSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8L1</accession>
    <name>H1V8L1_COLHI</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08103</name>
        <name evidence="3" type="ORF">CH63R_09432</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002037">
        <property type="protein sequence ID" value="CCF36564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156429.1">
        <property type="nucleotide sequence ID" value="XM_018304406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8L1"/>
    <dbReference type="STRING" id="759273.H1V8L1"/>
    <dbReference type="GeneID" id="28868513"/>
    <dbReference type="KEGG" id="chig:CH63R_09432"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09432"/>
    <dbReference type="eggNOG" id="KOG1618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030880_3_1_1"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="447" mass="48817" checksum="BFAAE7D4E2C39006" modified="2012-03-21" version="1">MAPNHRASSTGSFIENIVAARKQLDSMALSTPDSSLDGSDGSPGGSAGSSALGSPAGALSPVTPTLDAPVADSFAFAFDIDGVLIRGGRAIPEAVEAMKVLNGENEYGIQIPYIFLTNGGGKTEEERCGDLSKQMEIEISPAQFICGHTPMREMAERFNTVLVVGGEGEKCRQVAEGYGFKDVITPGDIIKHNSATTPFRKLTQDELTNSRERDFTDVTIEAIFVFADSRDWAGDIQIMLDLAMSKGGKIGTLSDTLDEGPPIYFSHNDIVWSAAHDNVRLGMGALRRMLEVIFKDVTKKKGKLHTHAFGKPQVSTFEFATRLLQQWRRQQHGLDAPPDTVYFVGDTPESDIRGTNLYNEHADNEWHSILVKTGVYQDGTEPAYKPKATVPTVLDAVRYGIQREIRKRVVSSLRKDILGEADCLRAMQEKDSAVLTPLEERTQPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9A7</accession>
    <name>H1V9A7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08292</name>
        <name evidence="3" type="ORF">CH63R_13557</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
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                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
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                <person name="Miyara I."/>
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                <person name="Will I."/>
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Arachchi H.M."/>
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                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Will I."/>
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                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
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        <property type="term" value="P:sodium ion export across plasma membrane"/>
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        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="EMBL" id="CCF37279.1"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAX1</accession>
    <name>H1VAX1_COLHI</name>
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        <submittedName>
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    <gene>
        <name evidence="4" type="ORF">CH063_08729</name>
        <name evidence="5" type="ORF">CH63R_12351</name>
    </gene>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR03224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12351"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Epimerase_deHydtase"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF37374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="339" mass="37047" checksum="35349B0F2D2EE770" modified="2012-03-21" version="1">MSDLTALPKGSLILVTGANGYIGSHTINTLLQLGYRIRGTVRSEKPWLTELFKNKYGEGVYEQVVVPRLDDPEALGQVMTGVDGVIHVASDVSMTDDPNAAIPWVVKATESALAAAAKHSSVKRVVLTSSAFAAVVPIPDKKGVHVDETTFNEDAIKAAWDPNTPKEIKPGYVYAASKAEGERAAWKWVEEHKPGYTFNTVLPNFNTGEILHPEIRGSTMGFARDVLKGQGDMLLAFMPQWYVDVVDVARLHAVALLADPVKSQRIWASAAPVNTSDFIDLFRELRPDNKLIPEKPASEGRDLTELPPAAKAEGLLQKYFGQKGWTPFRESVEAGIRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VB23</accession>
    <name>H1VB23_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00018</name>
        <name evidence="4" type="ORF">CH63R_02327</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002458">
        <property type="protein sequence ID" value="CCF37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162118.1">
        <property type="nucleotide sequence ID" value="XM_018297302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VB23"/>
    <dbReference type="STRING" id="759273.H1VB23"/>
    <dbReference type="GeneID" id="28861409"/>
    <dbReference type="KEGG" id="chig:CH63R_02327"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02327"/>
    <dbReference type="eggNOG" id="KOG0517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028348_0_0_1"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="407" mass="46529" checksum="306BD77EAEE4B45A" modified="2012-03-21" version="1">MDPRSHQRGNGPSTTDAQPPPLRRRLSMEEDYFYQEVMTSPFRRPSQPPPYERDAKPKRPLAGRDDVQHGMEEGLPGYSCDIELEGVWVKKMEIENTTKRAEDRNWHTAFVQLRGTALNFYNVKKDWGWGRTRDGPTISPDNPPWVRKASLDKAYSLQHADVGIAADYKKRRYVIRVRAETDQFLLSCIELSTMVKWLEALFAAIDVAAPIDDRDYPRDQSIPRIQRIRWFRGQTPAQTNNYPVPTPRPLSPELRRVTSVEVSEPFPSSSVMEAILDEPVIDESPIGEGGTAVVDTDSIYGPGPARNEQISSRLSTTSYPNEAIDPDTGKWAPEHQWTAAHDLLYAKLCYSVLLFKSPRKSNYIISKGKQWFVDWATGRMVRVLPPAYGEIDFFGPWQVIHTENRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VB55</accession>
    <name>H1VB55_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08778</name>
        <name evidence="4" type="ORF">CH63R_06901</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
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                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="MacDonald P.J.P."/>
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    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002502">
        <property type="protein sequence ID" value="CCF37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156156.1">
        <property type="nucleotide sequence ID" value="XM_018304133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBC9"/>
    <dbReference type="GeneID" id="28868240"/>
    <dbReference type="KEGG" id="chig:CH63R_09159"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09159"/>
    <dbReference type="eggNOG" id="ENOG502R1W6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130504_0_0_1"/>
    <dbReference type="OrthoDB" id="4844772at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="151" mass="16894" checksum="E856ED601E73CF85" modified="2012-03-21" version="1">MPVRKPALVDHRPEVERLAEAIDLRIGGATVPFDVLRVKEKDGCKIVHIYAHTPAAADDEDDGLSVTENETDDVGPSAEIEICLATEKWWMNVTSEIMYVADGNCEDGGKFISVLLYLAELNDEVAEEEEEEEEEYVKVYHGFQPEEINPS</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBK1</accession>
    <name>H1VBK1_COLHI</name>
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        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08897</name>
        <name evidence="11" type="ORF">CH63R_05360</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CACQ02002540">
        <property type="protein sequence ID" value="CCF37604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018300335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBK1"/>
    <dbReference type="STRING" id="759273.H1VBK1"/>
    <dbReference type="GeneID" id="28864442"/>
    <dbReference type="KEGG" id="chig:CH63R_05360"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05360"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030577_0_0_1"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Thioredox_PDIA6_C"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
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        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
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        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEJ5</accession>
    <name>H1VEJ5_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CH63R_04204</name>
    </gene>
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        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003079">
        <property type="protein sequence ID" value="CCF38648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018299179.1"/>
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    <dbReference type="GeneID" id="28863286"/>
    <dbReference type="KEGG" id="chig:CH63R_04204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04204"/>
    <dbReference type="eggNOG" id="ENOG502T4BH">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="3436397at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="80" mass="9225" checksum="8556598DB7733AA6" modified="2012-03-21" version="1">MSAEPNTKFAPEPKIQNKGRELSFKQKLDQAAHDARKPDEESRPNPIIEKGPPERPYDDTQVEEFIRQQHRSKGEDGLLE</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VER5</accession>
    <name>H1VER5_COLHI</name>
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        <submittedName>
            <fullName evidence="6">HhH-GPD superfamily base excision DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_09743</name>
        <name evidence="7" type="ORF">CH63R_08706</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003118">
        <property type="protein sequence ID" value="CCF38718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018303680.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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            <begin position="195"/>
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            <end position="145"/>
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            <end position="136"/>
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        <source>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF38739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF38739.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="OBR07685.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    <accession>H1VGG8</accession>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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            <begin position="1"/>
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            <begin position="18"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGZ8</accession>
    <name>H1VGZ8_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10319</name>
        <name evidence="3" type="ORF">CH63R_00020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003533">
        <property type="protein sequence ID" value="CCF39501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163357.1">
        <property type="nucleotide sequence ID" value="XM_018294995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGZ8"/>
    <dbReference type="STRING" id="759273.H1VGZ8"/>
    <dbReference type="GeneID" id="28859102"/>
    <dbReference type="KEGG" id="chig:CH63R_00020"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00020"/>
    <dbReference type="eggNOG" id="ENOG502RJDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055482_0_0_1"/>
    <dbReference type="OrthoDB" id="5293596at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="39364" checksum="88B6FAEE9ED38130" modified="2012-03-21" version="1">MNASVTTPLLHGHADLDDAHGLPTPASYGQIQDHPAFLRACHSPWRCFPQNLLCWVRGGVVAYLTAVGAMVLDYKLRQESPYSNWRVVFDFSVVTFSLLLAYHAVVLGWTYTHLYHPHIEETRTGWEYWALRVLSLPDDMASLRKQFYFTLFYTVATVFTFMNTVIYWFVTLEHDDKGNGEPPQPQPSGDSAVPYMIGDSLGYEWTRLEDAHKIGPHEPFTEIFGKGWFKAFVILNLFGVTSIISLFEIFYLNSIKRPFAVGAHTLGVIFFAGLYLGWAAIGKLETGADAFYWLNEKEVGSREAVVASSIGFVILAPIMYAFLYGLVGMRENITRAAHTRRVAAAAAVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIZ5</accession>
    <name>H1VIZ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_10828</name>
        <name evidence="5" type="ORF">CH63R_04889</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003928">
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        <location>
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            <end position="177"/>
        </location>
    </feature>
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        <source>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <name evidence="8" type="ORF">CH63R_11942</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004046">
        <property type="protein sequence ID" value="CCF40382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018306916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJH9"/>
    <dbReference type="STRING" id="759273.H1VJH9"/>
    <dbReference type="GeneID" id="28871023"/>
    <dbReference type="KEGG" id="chig:CH63R_11942"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11942"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
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            <end position="424"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="53645" checksum="ED30818C241E8E27" modified="2012-03-21" version="1">MRRVPVEKRSNSTRLVQSQGLVFADLVPSDASEPYWPDDRYYSFTLEEITLLEHAAKDVFDMCCEAVEYLVGHPDIITNKMAVPAFALKQIKESWDREPAWGSIYGRFDVCFGGLDHPDPRLRVPRLYEFNADTPTTLVEAASIQWLWLEQTGHGNDQFNNLTEALIEGWKRNLTLIEKELGHKPTVYFAVGEGDPTGEDAMNTMLLMDTCEQAGWSTKAMSMEEISLSTKDERFYDMQGNHIDVIFKLYPWEYMVEQQFAEACFKDMDNIGKRDNEGNYIGGTVWIESPYRMLWSNKSLLAILWDLFKDDPRSKWLLPAYFDGEAPASLTSFARKPIFAREGVDIVLKDNGKVIQDESAGVYGAEGYVVQELALPPEFKDTQDKSHYPVLGLWMVDGEIAGMGIREDESPVTTNASVFIPHSIEDGPVNYQRQTVPDEEGIELALRVDALHDQFDEGGENDLISYIKRVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKT3</accession>
    <name>H1VKT3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02442</name>
        <name evidence="5" type="ORF">CH63R_03447</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004334">
        <property type="protein sequence ID" value="CCF40836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163238.1">
        <property type="nucleotide sequence ID" value="XM_018298422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKT3"/>
    <dbReference type="STRING" id="759273.H1VKT3"/>
    <dbReference type="GeneID" id="28862529"/>
    <dbReference type="KEGG" id="chig:CH63R_03447"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03447"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="299" mass="31646" checksum="35A7DCDB1D10F974" modified="2012-03-21" version="1">MSAIKKVTVVGGSGNLGPSIIRGLLAGLFEVTALSRKESSATFPSEVTVKKVDINSLEEVTAALQGQDAVVSIVGTAGFASQKTLADAALAAGVKRFIPSEFGINTREARGTKIGGILTPKIQTVDYLTELSEKNSSFTWTGIAVGPFFDWDFSGGLLGFEVKNKTVNIFDSGNEPVSPSTLGFIGESVAGVLKNLEATANKYIQVASFTTTQRELLKVVEEQTGSTFTVNNVKTSDLEKTADEKLAKGDYSAFIQLLQQHLFGDGNGNATKDNAAVKLLGLQESDVKAETKKALAAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VKT7</accession>
    <name>H1VKT7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_02446</name>
        <name evidence="3" type="ORF">CH63R_03443</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004334">
        <property type="protein sequence ID" value="CCF40840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163234.1">
        <property type="nucleotide sequence ID" value="XM_018298418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VKT7"/>
    <dbReference type="GeneID" id="28862525"/>
    <dbReference type="KEGG" id="chig:CH63R_03443"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03443"/>
    <dbReference type="eggNOG" id="ENOG502TB0J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2249910_0_0_1"/>
    <dbReference type="OrthoDB" id="4843367at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="108" mass="11097" checksum="025CA52FD2AF66DF" modified="2012-03-21" version="1">MRNPFKPRKAPAQTWSAKRSSVLSADDPVFAGLDETERKSLEATPPIQHSQQTTSRDIPGEQPLKHAGGDGAAALSAGPSSHDSISTDSGHGFAAVSGSFADGSHSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2020-12-02" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VM35</accession>
    <name>DPCHE_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent monooxygenase dpchE</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diterpenoid pyrone biosynthesis cluster protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dpchE</name>
        <name type="ORF">CH063_11613</name>
        <name type="ORF">CH63R_05475</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IMI 349063</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>GENOME REANNOTATION</scope>
        <source>
            <strain>IMI 349063</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2020" name="Nat. Commun." volume="11" first="1830" last="1830">
            <title>Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.</title>
            <authorList>
                <person name="Tsukada K."/>
                <person name="Shinki S."/>
                <person name="Kaneko A."/>
                <person name="Murakami K."/>
                <person name="Irie K."/>
                <person name="Murai M."/>
                <person name="Miyoshi H."/>
                <person name="Dan S."/>
                <person name="Kawaji K."/>
                <person name="Hayashi H."/>
                <person name="Kodama E.N."/>
                <person name="Hori A."/>
                <person name="Salim E."/>
                <person name="Kuraishi T."/>
                <person name="Hirata N."/>
                <person name="Kanda Y."/>
                <person name="Asai T."/>
            </authorList>
            <dbReference type="PubMed" id="32286350"/>
            <dbReference type="DOI" id="10.1038/s41467-020-15664-4"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>PATHWAY</scope>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <comment type="function">
        <text evidence="4 7">FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones higginsianins A and B (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpchA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpchD through the action of the prenyltransferase dpchC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpchE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpchB (Probable). The short chain dehydrogenase/reductase dpchG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpchH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Finally, the FAD-dependent oxidoreductase dpchF converts higginsianin B into higginsianin A (PubMed:32286350).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="biotechnology">
        <text evidence="4">Diterpenoid pyrones display various biological activities and higginsianin A shows anti-HIV activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CM004458">
        <property type="protein sequence ID" value="OBR09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CACQ02004606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158300.1">
        <property type="nucleotide sequence ID" value="XM_018300450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VM35"/>
    <dbReference type="SMR" id="H1VM35"/>
    <dbReference type="STRING" id="759273.H1VM35"/>
    <dbReference type="GlyCosmos" id="H1VM35">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CCF41288">
        <property type="protein sequence ID" value="CCF41288"/>
        <property type="gene ID" value="CH063_11613"/>
    </dbReference>
    <dbReference type="GeneID" id="28864557"/>
    <dbReference type="KEGG" id="chig:CH63R_05475"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05475"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_12_2_1"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000451543" description="FAD-dependent monooxygenase dpchE">
        <location>
            <begin position="25"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="B8M9J8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="32286350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <sequence length="470" mass="52266" checksum="167250A6283FD688" modified="2012-03-21" version="1" precursor="true">MSEPHFKVIIVGGSITGLTLAHSLHKIGVDFTILEKRATVTPQEGASVGILPNGARVLDQLGLYGLVEEATAPLGATHIHFPDGFHFCSLYPKSMLDNFGYPVAFLERRRLLEVLYNALPDKSKVLVNKTVSDIEQCEDGKSAGVKVRTADGDVYEGDIVVGADGVHSRTRSELWRMSSSAGQSEDVRMEKARMSAEYSCVFGISRGPSGLKAGEQIMRMYDGRTLVVIPSKDDVVFWFLSRKLGKKYKYSEAPRFTLEDAAAECAELADAPLGNDVRFGDVWKIRQTFNMVVLEENLLRTWSFGRVLCIGDSIHKMTVNLGQGANCAIEDVAILTNLLSQCLGSKREAKPSGQELDALLRRFNDVHLSRVSHIYDTSWLIARVHARDGFVRKIIGRYVMPYFGHKFESRPFNMIANAAALEFLPLPRSSFPGWEKYKSKEDKSGSWAVVSRSVLLLVGLAILSTWWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>H1VND7</accession>
    <name>H1VND7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_00407</name>
        <name evidence="15" type="ORF">CH63R_00761</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CACQ02004902">
        <property type="protein sequence ID" value="CCF41741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164098.1">
        <property type="nucleotide sequence ID" value="XM_018295736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VND7"/>
    <dbReference type="STRING" id="759273.H1VND7"/>
    <dbReference type="GeneID" id="28859843"/>
    <dbReference type="KEGG" id="chig:CH63R_00761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00761"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="213"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF41741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR15581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="477" mass="52724" checksum="7305002C5BA6CEA1" modified="2012-03-21" version="1">MADVPKDLLAEVKKLEEQFTVPTEKLKQISKHFISELEKGLSVDGGSIPMNPTWVMSFPDGYETGTYLALDMGGTNLRVCEITLTDVKSEFDIIQSKYRMPEELKTGQSDELWEYIADCLAQFIETHHPDHPSSQKIPLGFTFSYPATQNYIDEGILQRWTKGFDIAGVEGKNVVPFLEAALATRNVPIKLSALINDTTGTLIASAYTDTKMKIGCIFGTGCNAAYMENCGSIPKLAHMNLPADTPMAINCEWGAFDNEHKVLPRTPYDIIIDKDSPRPGQQAFEKMIAGLYLGEIFRLVLVDLHDNKAVHIFENQDIAKLRKAYTLDSSFLSAIEDDPFENLQETSDLFLSKLNLKATRPELELIRRLAELIGTRAARLSACGVAAICQKKGYESCHVGADGSVFNKYPHFKARGAQALREILDWPAKTSAKEEDPIEILAAEDGSGVGAALIAALTLKRVQQGNMAGILNPENFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNV2</accession>
    <name>H1VNV2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_12040</name>
        <name evidence="9" type="ORF">CH63R_08033</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005014">
        <property type="protein sequence ID" value="CCF41906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157785.1">
        <property type="nucleotide sequence ID" value="XM_018303007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNV2"/>
    <dbReference type="STRING" id="759273.H1VNV2"/>
    <dbReference type="GeneID" id="28867114"/>
    <dbReference type="KEGG" id="chig:CH63R_08033"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08033"/>
    <dbReference type="eggNOG" id="KOG2820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_0_2_1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF41906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="49723" checksum="E306F42D8542FA62" modified="2012-03-21" version="1">MARPHPFTIHERGSTRHKSIIVVGGGVFGLSTVLWLLKSKPDCTIVLVDPTELSNPKAASHDISKILRDDYPNLLYAPLAIEAMDYWRTDALFKSFYHEVGVLRADPGGHNDKALATHHRLGHNSGASWLKPDDVQAKWSGFGTADFQGLDRVRYNPHCGWVDAADSLETVRQHVINAGAKLVVGEVGTLLFDNNDDCAGVRLAKGGDVLNGTVVLCTGARTSALLAESAPGRKELHAAHRLVATGALSFTITAHGEQRKRFEGIPVLKNCLPSVKGESMSMTANGTLKFNCDMAFTYKQLHVPSGTVMSLAPSDSHLTEWTAEEHVPRHLKNRAYKTLRGLYGDEMEDRVIEKYRICWDTTTPRHDFLITHHPRCKNLFIATGGSFHAWKFFPVIGKYVVQMLRGELEPEYAETWGWDRDAGGQVANSTYDIEGDLGEWIKEDEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VNX1</accession>
    <name>H1VNX1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_12054</name>
        <name evidence="2" type="ORF">CH63R_07286</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005026">
        <property type="protein sequence ID" value="CCF41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157039.1">
        <property type="nucleotide sequence ID" value="XM_018302261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VNX1"/>
    <dbReference type="STRING" id="759273.H1VNX1"/>
    <dbReference type="GeneID" id="28866368"/>
    <dbReference type="KEGG" id="chig:CH63R_07286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07286"/>
    <dbReference type="eggNOG" id="ENOG502S1PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_1_1_1"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="145" mass="15880" checksum="B56D055D1B94A5BB" modified="2012-03-21" version="1">MSGLQYFSYEGYGVNLLKDMHYSQAVRVGDTIEISGQGGWDPKTGEVASDLLQEIDQAFENVDLTLRDAGGEGWSQVFRIRLYALDEAWTPEGMGRMVENIKKWAPGHAPILTGIGASKLGQPGMRVEVEVSAYDPEGARKASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VP22</accession>
    <name>H1VP22_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_02724</name>
        <name evidence="10" type="ORF">CH63R_11521</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02005068">
        <property type="protein sequence ID" value="CCF41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153336.1">
        <property type="nucleotide sequence ID" value="XM_018306495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VP22"/>
    <dbReference type="STRING" id="759273.H1VP22"/>
    <dbReference type="GeneID" id="28870602"/>
    <dbReference type="KEGG" id="chig:CH63R_11521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11521"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_0_3_1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556717" description="Amine oxidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="69"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="517" mass="55489" checksum="60BA4C30133DEA97" modified="2012-03-21" version="1">MKPITHTAGLLTLLTPALGLAVGSQGGFGRSSTNLTTPALDPTKGNPATEIHEVPPQNGFDIIVVGGGFSGVMAAYDATQAGHKTLVLEARHRIGGRSQTQALHSAPDKLVELGATWINKITQPVSYALCEQFGLETAEQYTTGDVISQIANGTVHRTPQTLNQTGEPSPADLFNVLIATAANNTDIYNFDEFPEDEDVTLAEWVAKQGLWDEPGVKEAAGSLTSALVGRMPHELGAHYILDYIKSGKGLVSLSTEGEFGAQSLKIKKGTSAITDALVGTMEEGSVKVNSPVNRVVQLGGDGVLVTTIHGQRYKAKKVIIAIPTNTYSRIHFTPPLPASKRGLATRTMPGIYAKVILSYPAPWWREAGLVGKVFSEVGPISFGWETSDLETEQYSLAFFIAGDFAAAWHELTDLGREEAIVEHLATLVGSELADEARNLTEYNAVEWTKEEYLWGGPTSSMGPGMLRKYGVSLRESFGDLHFGGGETAFEWKGYLEGALTSGKRVAKEVIEALDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPL5</accession>
    <name>H1VPL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calcineurin is a calcium-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12242</name>
        <name evidence="4" type="ORF">CH63R_08802</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
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                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006294">
        <property type="protein sequence ID" value="CCF43687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154681.1">
        <property type="nucleotide sequence ID" value="XM_018305257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VTX9"/>
    <dbReference type="STRING" id="759273.H1VTX9"/>
    <dbReference type="GeneID" id="28869364"/>
    <dbReference type="KEGG" id="chig:CH63R_10283"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10283"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_5_0_1"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="250"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF43687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="486" mass="52946" checksum="FAA10B960B0B7D4B" modified="2012-03-21" version="1">MAAPESKTTPNEFFQAIGSKVDGSDDQQVVEEIESLCMNCGKNGITRLLLTSIPYFREIIIMSFSCEECGFANSEVQPAGSIQPKGTYYELRLTAMDDFSRQVVKSDTATVKFTELDLEVPAGKGQLTNVEGLLSTVINDLDFGQEARKEQMPELYPKIAEIIEKGRAMLEGKAFPFRLTVDDPAGNSFITPDLKDGVGKWEKHEFIRTPEQNEALGISNAQADELAAGANPGLTAEGDIIPNEVYSFPASCPGCMRPCTTHMKMVDIPHFKQVVLMSTVCDDCGYRSNDVKTGGEIPEKGEKIIVKVNGNIDLARDILKSETCALECPELNLSVNPGTLGGRFTTIEGLLTQVRDDLRSQIFEADGGSGGAGGGDSLAPEEKGRWTAFFDGLDEAINGNREFTVVLTDPLASSFVQPLVDPPAPDPSITREYYPRTHEEEEELGLLDMKTEGYEEDAAKEAVAREEAKKLAELDKLLDANMGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYX0</accession>
    <name>H1VYX0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Snare complex subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_14524</name>
        <name evidence="11" type="ORF">CH63R_08138</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02007751">
        <property type="protein sequence ID" value="CCF45432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157890.1">
        <property type="nucleotide sequence ID" value="XM_018303112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYX0"/>
    <dbReference type="STRING" id="759273.H1VYX0"/>
    <dbReference type="GeneID" id="28867219"/>
    <dbReference type="KEGG" id="chig:CH63R_08138"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08138"/>
    <dbReference type="eggNOG" id="ENOG502S73N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150783_2_1_1"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
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                <person name="Heiman D."/>
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                <person name="Howard R.J."/>
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                <person name="Koch C."/>
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                <person name="Law A.D."/>
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                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Shirasu K."/>
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                <person name="Schulze-Lefert P."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
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                <person name="Lespinet O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Arachchi H.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
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                <person name="Montmayeur A."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF45655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11499.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="376" mass="41452" checksum="E4962540CCF33D91" modified="2012-03-21" version="1">MSNNATTPAATGNAPSPAVAQAPPAGTAGDQNILAADDFSDDDGSSISHQSLTSSTTSITSSILDYRKENGRTYHAYKDGKYTLPNDDQEHDRLDLQHNMFIRSFHDKLGTAPPNELGAKVGRVLDVGTGSGIWAIDFGDDHPEADVTGVDLSPVPTDFVPPNVKFEVDDVEESWTFSQPFDYIHSRLMTGSISNWEKYIRECYKNLSPGGYLELNEGDAVPLSDDGTLTEDSSLMKAVRLWCEALAALGSPFEDVGRLVGVMKDVGFEDVHINCFKWPTNPWAKDHRHKELGIWNYENLSPNLEGFFMAPLTRGLDWTREEVLLLAMEARKDLGNRNIHAYYKMWSIYGRKPLKVEEEEEAPPAAAEAPVAVASA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1W291</accession>
    <name>H1W291_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Phenol acid carboxylase</fullName>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008867">
        <property type="protein sequence ID" value="CCF46604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151969.1">
        <property type="nucleotide sequence ID" value="XM_018307552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W291"/>
    <dbReference type="GeneID" id="28871659"/>
    <dbReference type="KEGG" id="chig:CH63R_12578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12578"/>
    <dbReference type="eggNOG" id="ENOG502RYFT">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_104261_0_0_1"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calycin"/>
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        <property type="entry name" value="PA_de_COase"/>
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        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF46604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="185" mass="21253" checksum="29041F8F8B926284" modified="2012-03-21" version="1">MFLSNKPPAKPLPRFQTNTPLDSTFDTDIRDTHLIYDYDAEDADGNPEKWRYEMWFFSEDRVVYAIHGGPMSGRVNYQTATYQCIRPGELWQVNWLEETGTVCSLVYDIPRQKISTLISFSRGHWENPEAAHGDKRNPGDVARWRVLARFGNQSDRFMLSEQADIVENFKGRGDLAPISGDAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1W421</accession>
    <name>H1W421_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_04090</name>
        <name evidence="2" type="ORF">CH63R_05365</name>
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    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
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            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009501">
        <property type="protein sequence ID" value="CCF47234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018158190.1">
        <property type="nucleotide sequence ID" value="XM_018300340.1"/>
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    <dbReference type="AlphaFoldDB" id="H1W421"/>
    <dbReference type="STRING" id="759273.H1W421"/>
    <dbReference type="GeneID" id="28864447"/>
    <dbReference type="KEGG" id="chig:CH63R_05365"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05365"/>
    <dbReference type="eggNOG" id="ENOG502T0DY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096182_1_0_1"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF47234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09673.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="15001" checksum="5E4D084E4E6368B1" modified="2012-03-21" version="1">MQLDDTFLSVRFKYGAHTILMFVDGQQKFSEITTSLLEVLRDRFPNGLTISHTSPETTALPETDVQLAYALPVNATDLTQGWRNIKAGDNDIPVAKGLKDNCVVAFSFDTDEPEFVADIPSLDEEVEDEEGMGSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1W423</accession>
    <name>H1W423_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_04092</name>
        <name evidence="19" type="ORF">CH63R_05363</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009501">
        <property type="protein sequence ID" value="CCF47236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158188.1">
        <property type="nucleotide sequence ID" value="XM_018300338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W423"/>
    <dbReference type="STRING" id="759273.H1W423"/>
    <dbReference type="GeneID" id="28864445"/>
    <dbReference type="KEGG" id="chig:CH63R_05363"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05363"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_0_0_1"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="257"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF47236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="549" mass="61135" checksum="53096581404ACBA3" modified="2012-03-21" version="1">MLSRAARIARLQPTAAQLYRSVATPAGRPQFLASSWSRTFAHDNKPKDPISGTPSDQQKPAGSTPGEAETPASSSSDYQAAYEEAAEASSKTSSTQTPKSDAKPDAADATEAPEPAAPTGPLPDLTQGIPSTLAYEMSGATNKAALAAMAEEDAVAQGGGRGRGELPDSAYVSSTDKKRQQFASRMFLAFIGFSAAGVVYLGRNWDDKEEEARHAETAPNGWSFGAWWARVTARTGDFMNYYQEPAFEKLLPDPDPSFERPYTLCISLEDMLVHSEWTREHGWRVAKRPGVDYFLRYLSQYYELVLFTSVPFAIGEPLVRKLDPFRFIMWPLYREATKYKDGEVVKDLSYLNRDLSKVIILDTSEKHVQNQPENAIVLPKWTGDSKDKELVSLIPFLEYIHTMQYGDVRKVLKSFEGKHIPTEFARREAIARAEFNKQVEAKKKKAPSGMGMLGGMLGLKPSNMSLMVSPDGEQNPHEALAQGKMLQDIARERGQRNYELLEKEIRENGEKWLKEEAAMQEKAQQEAMQNMMGSFGGWFVKGDDANKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4L5</accession>
    <name>H1W4L5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_15821</name>
        <name evidence="2" type="ORF">CH63R_09308</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009704">
        <property type="protein sequence ID" value="CCF47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156305.1">
        <property type="nucleotide sequence ID" value="XM_018304282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4L5"/>
    <dbReference type="STRING" id="759273.H1W4L5"/>
    <dbReference type="GeneID" id="28868389"/>
    <dbReference type="KEGG" id="chig:CH63R_09308"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09308"/>
    <dbReference type="eggNOG" id="ENOG502SB6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2203384_0_0_1"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="122" mass="13801" checksum="051D0CDD1B3CB6C5" modified="2012-03-21" version="1">MREHFRDRPAGRDLTGMLASLLQGLAGTDPKDVRSDYMLSRLDAEPERERLLSHARIEAGVNLDHPGFYKMRSMRASCWNVFITGVQEDRGGWEGYVTKALGFSNEGLVSIKGNLRVNKIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XR81</accession>
    <name>A0A1B7XR81_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_13508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150800.1">
        <property type="nucleotide sequence ID" value="XM_018308482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XR81"/>
    <dbReference type="GeneID" id="28872589"/>
    <dbReference type="KEGG" id="chig:CH63R_13508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13508"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="89"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="480" mass="51895" checksum="98CEFD1DCF0DD0A8" modified="2016-11-02" version="1">MEKIIAPAPIVQSVGYDDAHHQPVLAGDPVNDGGSHNQTIMSSNGDGHPRPQSQSLSEDRQRSVQTDEEKAELVPPIADGPDGGFQGWMQVVAAFLLVLDGFGFITAFGAFQTYYRQLLPDSVSDQAISYIGSMQIFLLFLLGTISGRLIDAGYFRITLITGFVFQIGGVFGASFSSQYWQFLLSQGIATGIGNGMHFTALVWLVSQYFTKKRGLALGISSCGAPIGAVIFSLIAREMLKENTGHQWTLRVMGFLILADSIIIILIARPKEATRKGGPLLELSAFKELPYLLFTIGMFFALLGVYFAYYYVPNFARDKLGLDSDGALTVLIVMSAVGIPGRLIPPFFADKSIKPLRTLVISLLFCSLNLFAWIAVTSTAGLYAWVVAYAFTANAVQTLFTASMGEVTSDMSKLGVRIGMVFTVVSFACLTGPPVGGRLVEVGGDNYAYAQIFAGASMLLGGLLVALAKMKQVGQKEFWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRM9</accession>
    <name>A0A1B7XRM9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase s41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150929.1">
        <property type="nucleotide sequence ID" value="XM_018308611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRM9"/>
    <dbReference type="GeneID" id="28872718"/>
    <dbReference type="KEGG" id="chig:CH63R_13637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13637"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600997" evidence="1">
        <location>
            <begin position="21"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="557" mass="60674" checksum="A81EF81720A124BA" modified="2016-11-02" version="1">MVRASSYLGSLAVLAASAVAKEIQPNEAIAAELYDSGKIHEQVIASKKAEFARQRAAGAYNSELWPELGYTPCVNGWAEAVVGDRLNTFRCHNADLYSFLSHAALGGPLAEGSSSWGWTNDDGREFVAIGQYEGTAFAEILSDGKLVYLGRLPQYSSPSEWREIRSYKHYMVIGSEAVGHGIQIFDMKKLLDIDPASPVVFDAKLDLTSHFNALLPLGRAHNVVINEELNYGVAVGAMPRSDPLCAAGLNFFDLTDPANPVSLGCAKGDGYVHDAQCLVYRGPDKRYQGRDICYGYNEDTLTIYDVTDKANVTNIISRISYEGASYTHQGWVLDVNNQEFLVLDDELDEVRGNGPGGDGYPVTFIWDIRDLENPKQTGVFTHPTKAIDHNQYVIDNYIYQSHYGAGLRVLDGRSIPTDPTGAGVCEAAWFDIYPEDDDFEGGGYVGFVGTWSSYAYFPSGYIFINTIERGAFVVKLTGKDCPKAPVCNADNCLRSFRANSIPGRLEESQAFCKTFLSSPVKDAAVLPSHAVQNCAKEDKVAQASSACACLPTATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS69</accession>
    <name>A0A1B7XS69_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_13864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151156.1">
        <property type="nucleotide sequence ID" value="XM_018308838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS69"/>
    <dbReference type="GeneID" id="28872945"/>
    <dbReference type="KEGG" id="chig:CH63R_13864"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13864"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="7"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR02638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="512" mass="57143" checksum="0D0C871FD4557204" modified="2016-11-02" version="1">MAAPTYTLAEGVPYADPTTAQHFGGNSIKGLMLLQDTQLIETLAHFSRERIPERVVHARAAGAFGEFEVTHDVSQHTSAKFLSGIGTKSKVLLRVSTVGPERGSADTVRDVRGWGMKIFTEEGNQDWVFNDIVSRQPFFSLLKVKLIRQPVFFVRDPIKFPSLNRSHKRNPRTNVTDATMADHSSFHNNNQEGIHALMHLFSGRGTPKSIRHLNSYSGHTYKLTKDDGTFHYVKIHIKTNQGVQNLSQDEAVRLAGENPDYHTADLYGAIEAGDFPSWTVFFQIMEPQDAEKYRWNIFDMTKVWPHSDYPLIPVGKLTLNKNPSNYFADIEQAAFSPSNMVRGFAPSADPMLQARMFAYNDAARYRLGVNYQQLPCNRAVSPVYCPYQRDGFMTFGDNYGADPNYVRSDLKPVNYVGSHGASGYAIGGHEDWVGHVCGFTSEVVDDDFAQARAFWEVLGKQPGEQEALVHNVAQHMGGAAPAVHEKAFGIFARVDQDLGERIRAAVLGAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS80</accession>
    <name>A0A1B7XS80_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_13859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151151.1">
        <property type="nucleotide sequence ID" value="XM_018308833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS80"/>
    <dbReference type="GeneID" id="28872940"/>
    <dbReference type="KEGG" id="chig:CH63R_13859"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13859"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF6">
        <property type="entry name" value="AMIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR02633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="583" mass="62809" checksum="13D505FC4A05663A" modified="2016-11-02" version="1">MSSQPKQESWKAIARRKQAERAGHIPSKWHIPSHVLPKDPPRLQDGPQNVLDIPRQFLSPAEVSVTESYTIPQLCQAVSSRSLSAVEVAEAFCHRAAIAHQLTNCLTEPLFDAALQRARYLDEYLREHGVPLGPLHGLPVSVKDTFDVAGVDTSIGLAYLCHKPAARNAPLVDLLLSLGCVVVAKTNVPQTLASLDSVNNVFGRTMNPVNRLCTAGGSSGGEGVLVAMRGCMIGIGTDIGGSIRVPAMCNGVYGFKPSNGRVPYGGQALTGVEGLSRTSVQAVAGPIGRSVEDIDSLMREIVPRAALWGEDCMPATWSPGPRESSLVSPSGSGKHGELVIGILRTDGNCNLHPPIANMMDEVAYFLATTPGVKVVELGCPPAWTKAQSVMNKLMGADGGVTMAEMIEATGEPLVPWTASRFKKGRPQPLPRLAELQAQRARLEREMLGIWVEDDEHGRRRQKLDALVCPVAPHPVPPIDGYNAVGMTSSWVLLDYPAATVPVRDVKESDLQLGRPQGGKVLGSWDQRNRELWDESKIDRRVYLGTPLSVQVVVPRLQDDRLVDVMGCVDAACKRKGGNAHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTY0</accession>
    <name>A0A1B7XTY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethyl tert-butyl ether degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151747.1">
        <property type="nucleotide sequence ID" value="XM_018307330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTY0"/>
    <dbReference type="GeneID" id="28871437"/>
    <dbReference type="KEGG" id="chig:CH63R_12356"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12356"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601066" evidence="2">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR03229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="19569" checksum="8F4C8092B15A7562" modified="2016-11-02" version="1">MVRLAVPFAIAATLLAGGMASCTNTGQAQMVTYVKRAANVTRDRFWNYWQTEHAPKVAPLAVYFNITRYQQIQVGGQILPTAAGSTEPAATEPVEFDGIAMFLYKSDEVLAAMLAHPYYLEVVEPDEHVFIDKAAFGAGMVATFVGTDIEIVDGRTDVWVGNRATREKYDKVFQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVU1</accession>
    <name>A0A1B7XVU1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152417.1">
        <property type="nucleotide sequence ID" value="XM_018308000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVU1"/>
    <dbReference type="GeneID" id="28872107"/>
    <dbReference type="KEGG" id="chig:CH63R_13026"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13026"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="24231" checksum="A0D6E0F44FEDE63F" modified="2016-11-02" version="1">MAVRTATESSIRTLSLQKANLSHPDRIRKDPVTISEPTRKTSERCVVMGHGHPCAMPKEARARCGGNEPQAYTRGGAQHARRAACQQPAVGVDLKTVLKAKLHSEKPQRHRQRLRGTRNGRVPARLHQPERPDGRSRHGFKPPCAGGVRAFEPQHSHKFPPGIWVDAWQGLKDEPQYPPPAAAAKTTRRANERTRKRERERAREREREREGERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX68</accession>
    <name>A0A1B7XX68_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+/H+/K+ antiporter P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_11070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152885.1">
        <property type="nucleotide sequence ID" value="XM_018306044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX68"/>
    <dbReference type="GeneID" id="28870151"/>
    <dbReference type="KEGG" id="chig:CH63R_11070"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11070"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1034"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122101" checksum="F23C9C2104FF90A9" modified="2016-11-02" version="1">MDESEKQQSQTAGERIRWDADEEAGRKAHRSSAGPALHHARSNTSMSIHSIRSRRNSIDAAAELPIQYRTVSIEIEEYKTKSEAIKKAKNVATELSELEWHILSVDEILRRQSSSLADGLSPDQVQRRVAHYGRNAPSPAPTNHTKRILGYFFKGFGTVLLLASVLVFIAWKPLGSPPAVANLALAIVLLAVFFIQAAFNMWQDWSSSRVMNSIKTMLPENCMVIRDGHQAELLADQIVPGDILIVKSGNKLPADVRFLKVSSDAKFDRSILTGESVPLPASVDSTDNNYLETRCIGLQGTHCVSGTCTGLVVATGDNTIFGRIAKLTNEPKKGLTTLEREVLHFVLIICSIMFLMIVIVLIVWGTWLRKQYPNWINVPNLIISCVSVAVAFIPEGLPVALTASMTISANMMRKNKILCKSLKTVETLGSVSVICSDKTGTLTQNKMIVTECAIGTMTMTAEGARDALTLNKHNAPHNNSMEQLRAIAGLCNAGQFDAATMRLPLHERVIHGDATDQAILRFSESLGQVAELRRCWQTKYELAFNSKNKYMIRVLGLSHPDGLSFALPSDTASVFQPGDVLLTIKGAPDVLMPRLSNYINPSGYTTALDPSTRASIEHIKDEWSSQGRRVLLLARKAISRSALKGSPSDSSYEMEINNQAKSGLTLVGLVGIVDPPRPEIPEVMNTLRGAGIRIFMVTGDFALTAQAIAAECNIISVPRSQIDDITALQRVSHVDPSIKPVMDDLESSPRQALVLSGPELMTLNEEQWDQLAQYQEIVFARTTPEQKLRIVRELQARHEIVGMTGDGVNDAPSLRAADVGIALGSGSDIAIEAADMVLLDSFSSVVEALRYGRMMFDNLKKTVAYLLPAGSFSEFWPVMTNVMFGIPQILSSFLMIIICLFTDAAAAIAMAYEAPEADVLLRKPRVPGKDRLVDWQLVVQSYGLVGVLETLSSFAMSYWYLERNGIKFSDIWFSFGNLPSTIDPDYYQQKLNIASSIYFVNLVVMQWFNLMAIRTRRLSLFQHPPVGNRRTQNLYLFPAIAFALLMAIFWLYVPEFQKTLGTAPVPVEYWFLPMTFGLGILLIDEARKFAVRRWPNGILAKSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX94</accession>
    <name>A0A1B7XX94_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7909 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152882.1">
        <property type="nucleotide sequence ID" value="XM_018306041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX94"/>
    <dbReference type="GeneID" id="28870148"/>
    <dbReference type="KEGG" id="chig:CH63R_11067"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11067"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057231">
        <property type="entry name" value="DUF7909"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25486">
        <property type="entry name" value="DUF7909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601150" description="DUF7909 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7909" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="19912" checksum="494727DCA5742762" modified="2016-11-02" version="1">MLTSVVAAVLSTAAAASACVPPTEPLSNNIPEGFGIQIQNVSVPVIHNRYINLWSAGGGDQHLYLSPAGDSAFNLTLVNGVISRGIIHAVINGEYTADDNTTKMFMTQRGDPKAFFQPVYGCNPDTDAVQIELDFVSRASLPGGFICFRSASGERHEARYSPPGNTVFRADRPCFEVTLAVVPVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYZ6</accession>
    <name>A0A1B7XYZ6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153490.1">
        <property type="nucleotide sequence ID" value="XM_018306649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYZ6"/>
    <dbReference type="GeneID" id="28870756"/>
    <dbReference type="KEGG" id="chig:CH63R_11675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11675"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="33436" checksum="56C030507B25B53C" modified="2016-11-02" version="1">MQRESSQTSWLYRIDERHHNPLLLLFPGTARKDKSTMAQVPVQTIHRDPQLLYWILFPITVVMILTGILRHYATVLLATPPKKLEKAALKEQRAMMHGVTVRTNHHVLSKKSFEARRDALITAYESGAYLKDPDRKGQPPANPLTDPGAMDGMMGMMKNNMAMIIPNTLIMSWINAFFSGYVIMKLPFPITIKFKSMLQAGVATKDMDPRWMSSISWYFLCIFGLQSVFNFILGSDNAASQMAQQMGQMGGAQGAPQMFGPGVDPDKQFKGEAENIAVVEHYSVLDDVEQRLLAGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ86</accession>
    <name>A0A1B7XZ86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153605.1">
        <property type="nucleotide sequence ID" value="XM_018306764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ86"/>
    <dbReference type="GeneID" id="28870871"/>
    <dbReference type="KEGG" id="chig:CH63R_11790"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11790"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="252" mass="27517" checksum="41DABDB7DF24F608" modified="2016-11-02" version="1">MNHLDFTPSQTSTNMSYTAPSQRITFDGFLFDMDGTIIDSTEAVVKHWHTVGNEIGVAPDVILETSHGRRSIDILKILAPEKANWEYTREMEGRLPRLYGKDAVEIPGARALLDALIEEKAPWAIVTSGTEPLVGGWLNVLQLPQPEHLVTAESVENGKPDPTCYLIGREKLGLQDPSKQILVLEDSPAGIRAGKAAGCKVLGLVTSHTVEQVMSAEPDWIVRDLDSVRVVESRDGVVTLEFSNALVPNPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZW1</accession>
    <name>A0A1B7XZW1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_11996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153811.1">
        <property type="nucleotide sequence ID" value="XM_018306970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZW1"/>
    <dbReference type="GeneID" id="28871077"/>
    <dbReference type="KEGG" id="chig:CH63R_11996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11996"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="76" mass="8410" checksum="9FBB131A95BC56DE" modified="2016-11-02" version="1">MLGHFFSEHMDERYILKSVVGQPAEGLCVLKRFPDSIILAKPRSFQGHSHTTHGLMETASRAIYTGSMIGVVPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y069</accession>
    <name>A0A1B7Y069_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153908.1">
        <property type="nucleotide sequence ID" value="XM_018307067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y069"/>
    <dbReference type="GeneID" id="28871174"/>
    <dbReference type="KEGG" id="chig:CH63R_12093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12093"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="697" mass="74613" checksum="07484C7BDBA14FBA" modified="2016-11-02" version="1">MASLPPFAPFPPSKWRASLTPQDWSSLLEAWTALANAHLALPDAQLFSTAAASLPPFFASFVAELSTDAAGHPLIPGASSSPSSTSAHLKPLLRAVFALTSRLLTSPTHPPPPELATPAFLAAFSRLYRKNSPATLSASFALHAPTLEPPLASLKRTLTKSLEAGLKADLKTLEARLASLNHLLHACPAAAAFFLAGSDFLDGLVSAFRITNPPLRKVLVATAYVGLVGLAAADRFGMLADVLFSLKSAAEAHKAGPLNVNDSLVAELVTVTPVLKQLLRKAEDKGAASTALRSRIAALEGFRKPGGGMMRPKRLVKRKIDKGKGKDVADESQVQAELHMHRQSQISLIQDLFPDLGSAFISKLFDEYGDNTEVVTAHLLEDSLPPHLATADRAAQLYVLIETCLIHHDLLLILYRSPKLERRKSQLEPRPTPPQLPERHNVFDDDELDRLELDVSKLHFGKKAPERTADDVLRDRSTAPNKAAILSALAAFDSDDDERDDTYDADDVGGTVDNANEEADGQKDANEETLYKAFQADPSVFDRQATTRRGPARGKLRVETGMTDEAIEGWAVMLARNPGQKRRLEAKYNGAAAFTGTQTEILSTAWRASPAGSGAEESDPDGGSSSRGGRGGRGRGVGGRGRGRGGGGRGGGNVAGPTGEKETEAARRRKEASKGSRANHNRRDQRAKKMARGGFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0W3</accession>
    <name>A0A1B7Y0W3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154141.1">
        <property type="nucleotide sequence ID" value="XM_018304717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0W3"/>
    <dbReference type="GeneID" id="28868824"/>
    <dbReference type="KEGG" id="chig:CH63R_09743"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09743"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="330" mass="37178" checksum="0FFA569BA61F93F3" modified="2016-11-02" version="1">MDDVRTTSVFKALSSFFMSENFSDMKITCGGGVYSAHRVVVCGQSSFFDKALSGTFKEAATATVDLPEDDPDILEKFLEYLYTGNYDDKVVLKLNTPANVALMNHEEVMEKLSHPPGVLLPVRPLKGTRNLESKPGERGIKSSRSTLDSDDDPDDSNYQASDHGRQPPGPEDRVKTENEEEEEEEDGLPVEIEQDYNPTRAVVDGDPATDRNVFIRDQAAVRNDLFLHLRVYVMADKFAVPALKLLARDRFYRAAELAWDVADEFPDVVDELYTNTPDTDVDMRGIVCRLVGNNVFDDRVRERLEPVMRKHGDFAVGVLKHVIAESKERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y146</accession>
    <name>A0A1B7Y146_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154248.1">
        <property type="nucleotide sequence ID" value="XM_018304824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y146"/>
    <dbReference type="GeneID" id="28868931"/>
    <dbReference type="KEGG" id="chig:CH63R_09850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09850"/>
    <dbReference type="OrthoDB" id="4842676at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="294" mass="32688" checksum="B20657648FEE717D" modified="2016-11-02" version="1">MPDAKKATTERPPAPVTDRRPKREIPADIIDTNPFSLDMSQGITRGAMPPFTLGRSPLAPRHPARIAAEPSRDRVNQKPDHVPLRPATPTPYRRPRTPEPHPESPPSAFRTPESSSSSSSRRTVTRLRVVEMETSPATSGSGSGSKPSLDTEGDVRMRNGVWGSPEAARLRQREEVRAMVTQSVHDNFEFERARFADEIRTQLLATVAEDVRWLVRENFEAALAGALGRPAEGEAVAVQLVRERLGRLSNGALARVFCTPEMLEVLRRMVCAVDLEMRTEAWSLVEADESWQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1I4</accession>
    <name>A0A1B7Y1I4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154380.1">
        <property type="nucleotide sequence ID" value="XM_018304956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1I4"/>
    <dbReference type="GeneID" id="28869063"/>
    <dbReference type="KEGG" id="chig:CH63R_09982"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09982"/>
    <dbReference type="OrthoDB" id="4843147at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="215" mass="24773" checksum="772FE6AFC17DF41C" modified="2016-11-02" version="1">MSEATPPKGIEAWKVWSKQQIHSAFFLTEPDVSNTYRFDEELGVYLGFAGKEVIKQLENVAWDDESQAPADKTKQQVYISMVHGPRRIQPHYVPFASDLEALRIINNLRLPDDIVDSLTQAVKFGVRNDAEDFGSTISFDSPASDTGYGSHRFHHEIHYYETPWNERRSQGTPTLSNRHDDYGFLVKVYYEGDTEERSENWPKDAPRLEEMGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2G0</accession>
    <name>A0A1B7Y2G0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_10312</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154710.1">
        <property type="nucleotide sequence ID" value="XM_018305286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2G0"/>
    <dbReference type="GeneID" id="28869393"/>
    <dbReference type="KEGG" id="chig:CH63R_10312"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10312"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="15">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="124"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR06192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="561" mass="61674" checksum="5336B4A72518DAE6" modified="2016-11-02" version="1">MATNGTTNGETGANAAAAAPAPVDTTHTPSQRYLSTRGEDSGFSFEEVVLKGLATDGGLFIPEHIPQVDDWQSWKDLSFPDLAHKILSLYISPSEIPSADLKGIIDRSYSTFRAPETTPLRHLHDNLHLLELFHGPTFAFKDVALQFLGNLFEYFLVRKNEGKTGTDRHHLTVVGATSGDTGSAAIYGLRGKKDVSVFILHPKGRVSPIQEAQMTTVLDNNVHNLAVTGTFDDCQDIVKALFADPDINSTHNLGAVNSINWARILAQIVYYFHSYFSLAKSSDSFKLGDKVRFVVPTGNFGDILAGYFAFRMGLPVDKLVIATNENDILHRFWTTGKYEKQPAPPSEATGGLAQDGVKAHEDGVKETLSPAMDILVSSNFERLLWFLAYEFASSAGMDDEWNKRQAGQEVSAWLKDLKTKGGFGPVYQDVLNSARRDFESERVSDSQTVETIKGYYNKIGYVLDPHSAIGVSASERSISRAGDDVPHISLSTAHPAKFAGAVDLALKEEPGFNFQEKVLPSEFVGLEEKERRVTEIANDWQKVREAVRAQVDEELKAAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3A3</accession>
    <name>A0A1B7Y3A3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155009.1">
        <property type="nucleotide sequence ID" value="XM_018305585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3A3"/>
    <dbReference type="GeneID" id="28869692"/>
    <dbReference type="KEGG" id="chig:CH63R_10611"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10611"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="199" mass="22151" checksum="D008A7987A5CDAE6" modified="2016-11-02" version="1">MGKDPTQASRLRDDGRTRVAKLQGKMRSRHDQKTYVTCNRGGKKCGWRRPAAERSLARMLCEQGWTVAPPGLASEQDPLTPYDFEPDPQGAAFVIEWKLAKILKDAGWKVAPPGMQISPTDTLKHHGTLPNYQQNQFPTPKGTAEHDSTQIIERRDGPLHEPSLTGILGGALAPESSSSSKGFYRFSTQQFRQRRIEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5L9</accession>
    <name>A0A1B7Y5L9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duf431 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155869.1">
        <property type="nucleotide sequence ID" value="XM_018303846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5L9"/>
    <dbReference type="GeneID" id="28867953"/>
    <dbReference type="KEGG" id="chig:CH63R_08872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08872"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="199" mass="22135" checksum="4F11F23E974B410B" modified="2016-11-02" version="1">MPGKTYIVEHLDPELGPWSELEYIAIAKETHAAAGTFLLSSLPAGFVAPDKLKQVPAFKAESRGVEELYAHDKSRVCLLDPAAASDLSPEDGEKFDAFLFGGILDRTSELRKKGFEGRRLGPTQMTTDTAVRVTRIVVEEKTPLDKIPYVTYPELKFSEHESTEMPFKYVTDKDGQPIMPEGMVDLIKKDADKAIDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Q9</accession>
    <name>A0A1B7Y5Q9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155834.1">
        <property type="nucleotide sequence ID" value="XM_018303811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Q9"/>
    <dbReference type="GeneID" id="28867918"/>
    <dbReference type="KEGG" id="chig:CH63R_08837"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08837"/>
    <dbReference type="OrthoDB" id="10560670at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="878" mass="99926" checksum="554A74DEAE78F8A4" modified="2016-11-02" version="1">MTDETRKREQYENEYDRQYHIRKYAATAAQIINNAAEEVPREKIAALAGDVGRKLKHYATKNQSASTIYNDVRRQPIESDNAELSSIIAIRAHVDITMIRKVAPALTKKFLEEMPLNCPDIDSYITAKIQSLRNSPYQPAQKFKESHMKKPGHWGQEIHNISGVANIEDHKRTLIPPIEGGEAVMTLNQWRIRENESRQDQNEKWERLLTAMMRGEIRESAKLKRLDDGRGPPIIEELDQIDITCVAARHGTKEHMNATMGRQASLLRFRHRTQNATPSANTPPPPKLYECPKCYVKAEWVDSIIWHWQTNHEEEDGLFEESAEGEWWADFHTWRGTRRETRCLYCYRSDDWEEIHSTKNVTPGSGICYTELTAREHEIWHRHQLDKANKRARSASTDNDDAESEIDQSSPKRQKADFDFTLIHIENRGPDMCPDCYTIAASYKDLVECIHHWTEKHGEEMAVHSSLVPDMEAFEEYLQDADVVCEFCPEDGPLHMDQRSLAIHQKRQHDDNMGQASAPGLDPCMVPGCDTMLDNIGNHMNDKHADTHFHCEYCLRKTGTSQYHLRESRATHLVSHIADFPRDPSRNYDPVVRQEPLLMYLQLENDRQAANTRGEIGTALRKAWKTLQDDTDEEKAIKINKAYRMAMGRQTAPQKDRAFVSGDEALIRAEIANVPETGNEEAARGHWMTISVQDMQDAASGNQTRLCDCQINNNMALKDWIAHFKESAPGDGLEMSDLRRIDTSRRLRETRPGLPIDCDGGSGNRGDTASANLALRRVRRKQGSLQRHVQPSPSEMGKKNMLYTETIARQSCLQFRKAAPEPSLLLRLPLRNGSHAGQAQAITPAVDADIANTIPMKVQNGATMMVTKASVAGEETYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y658</accession>
    <name>A0A1B7Y658_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156011.1">
        <property type="nucleotide sequence ID" value="XM_018303988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y658"/>
    <dbReference type="GeneID" id="28868095"/>
    <dbReference type="KEGG" id="chig:CH63R_09014"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09014"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="312" mass="34385" checksum="6145B7D80B1D5AB8" modified="2016-11-02" version="1">MHVHVKVTWNLLVARSNASTSGDLSTHLQPLNLLQVPTSGPNTGPVTPSTYPPYRPWGNRKKGSNHPFLPLLWQSAGLAGLSKCGCESQALRPVTAIILTYCFVSSYAAPFYAPPPTPPSDSTEGFPLRPPPDNPNRSFPRPDLWCTHQPRKHTFCSLDRLFGTRVLWRINVTQSAPDIVRGGISHRRCQSCTTRPPHRPKLTYTMEGEGEAWYPSSLPQGKEHLASEDELTCIAKPAARREAGNTKRMDHIARPGPGLAHWADSGTPMSAIFAPSQTTALVWPCMSARCFQEMQASLFMKLSLRRSGEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7R8</accession>
    <name>A0A1B7Y7R8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_09558</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156555.1">
        <property type="nucleotide sequence ID" value="XM_018304532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7R8"/>
    <dbReference type="GeneID" id="28868639"/>
    <dbReference type="KEGG" id="chig:CH63R_09558"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09558"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="42"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="14">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="487"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR08037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="593" mass="65968" checksum="6F2A5B395C085520" modified="2016-11-02" version="1">MCTPNVALPADSADPMAACSQFTHYDLHLLAQSSPESPLRVVALVDYDSFYAQYEAVRLGLPASQPLAVRQWNAIIALNYPAKQHGLKRGISVDEARRLCPGITIQHIPTWREGDDQWRYREDVLDHLTTDKASLDPYRHMSRKTIQLVRDLFPASPDPIIERASVDEFYLDLSTQVYRTLLDRFPDITSDTISTQKLPLPAVKNPLNWQMDRVMNPPERGDHGESPDWDDVALSVGADIVRNIREHIKQRLRLTTSAGVSHNKLLAKVASRMQKPAGQTVIRTKSIGSVLSALKATSLPGLGRQLGQKAVQGLGSDNIFDLLQVPLATMITQLGSEQGHRVYAAIRGADRGAVVPRCQVQSLLSAKTFVPPVASLQQASKWLRIFAADLEARLHDLDVSSDFPRRPKTIAVHHHVRGRFGPTRSKQAPIALQTMINQDTLFDLSYALLTALTADGESWPCQSISVSLLNMDSRAPEKGRITSFFAPSAVHSSQRRRRSSSGPEINVENERKKKMRSSIEHLEPTEMSDTSSISVVDGRGTSSGVLTSPSLPWRESQYECPLCNGSVEPEDVLEHLDWHVAEQIQHQENEPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7W1</accession>
    <name>A0A1B7Y7W1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156644.1">
        <property type="nucleotide sequence ID" value="XM_018304621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7W1"/>
    <dbReference type="GeneID" id="28868728"/>
    <dbReference type="KEGG" id="chig:CH63R_09647"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09647"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF215">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="456" mass="49932" checksum="E5ABBF5B2C396420" modified="2016-11-02" version="1">MPATKRPGTHQFGKSSGIVLDIGIVGAGIAGLTAAAAATLIRLGHSVYERSRFANKLGAAVNVGPNAAPVLDAIGFDRKKARLVEVMEGKQFDGATLKVNYSGKYDDFASRFHAPWYFSHRVDLHNELKRLALEPPAGVTPATLHLSSPVASVDCEAGLLKFQDGTELQKDLIVGADGLHSVVARSVLGTDIPAGVVNECAYRFLIPTSKLLNNLVTKPLFQEDVATFHVATGSDRRLVWYPCRDGQVQNFVALHPSSVYKKGPAAKEDWHGRGNVDDLVETFSGFHPSLVEICRHARLRSLWLKTLRDLSDVAAGLISNAEDLKLWQLAYRGPIRQWTSGKAILIGDAAHPMLPHQGQGANQAIEDAGALGVFLANVKDRNEVPRRLESVQNIRRDRAGAMQIFSNAGQDESHRIEKEVQPFIKGPVPKNQAEFHDWNFSYNILTDCQDNVARLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7X6</accession>
    <name>A0A1B7Y7X6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156657.1">
        <property type="nucleotide sequence ID" value="XM_018304634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7X6"/>
    <dbReference type="GeneID" id="28868741"/>
    <dbReference type="KEGG" id="chig:CH63R_09660"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09660"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="246" mass="27256" checksum="E0F676A20073E476" modified="2016-11-02" version="1">MGVDSLMNIVLVSKIRAEKDIEILATKFRQCFTLKPLPLPATAPEDSVAEHTDVQTGPEALPDRLEDDGWGDDDDMGTPLTNASTPVDISRPDSTESDMSLIDFKVPKPMMNVPLSVIGGGVDDFNYVVEDFLIQGEEKEGVPYLFLFPDGSGLVTSFFQLPDLSTTNLCVYGLHSPWVKNPEDFTCTIEQATNLYLAAIRARQPRGPYLLGGWSSDCYYTTRSEQGENSRTNNTEKSSFDFHPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y876</accession>
    <name>A0A1B7Y876_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">X-Pro dipeptidyl-peptidase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_09646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156643.1">
        <property type="nucleotide sequence ID" value="XM_018304620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y876"/>
    <dbReference type="GeneID" id="28868727"/>
    <dbReference type="KEGG" id="chig:CH63R_09646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09646"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="328"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="624" mass="70693" checksum="FFE5A44F6BA022F6" modified="2016-11-02" version="1">MPLPIKDLHTVEVFPGYVAEFNVDIPLRTATKTLPHDPLLVRDNVYRPKGESKHPVLVTESREKGHGVNRSSEDRFHPKSFAEVDQEQKSQHSTWETPDPGFWTSHGYVVLRVDERGCGQSPGMLDSMSRTTSDAFFDVVKWAAEQPWSTGKVGLLGISYYAGSQWRVAARRPKGLAAIVPWEGMSDYYRDRVRHGGILSNTFIDWWWNRQVVSNQYGLAGRAARNWGPDTLEGSLPESELREARRSQPADTAEFRFRDDEYYSTKDFDLADIEVPLLSVANWGGILLHLRGNVVGYMQAESKFKYLRCITGRHDLPFYYPEEVKVQKSFHDAFLKGEDDVGWSVPGRVPPVDICLRQPGLQQPSAERTSFPRRQESEWPISRTQYIRFYLAGPGEMTTEEAPERQLLKHEAMTGELNFHTKPFTEAVEITGHSLTSSPLFLDQDGFTPSDMDIFVTVRHYDVNGDESRTPLQPPDLYECPLPRLFYTGTTGEPVPVAKGWLRLSLRQVDTTDPRHRHYLPHQNYRSSDVLPVDAGVEYPVDVEIWPTNVVVAKGHTLGLQIAGHDTQGSGLFEHTHPEDRPKSVFDGLNRIHVGPGSQSYLELPIIPQLRNTPSDLSEGHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8D6</accession>
    <name>A0A1B7Y8D6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156817.1">
        <property type="nucleotide sequence ID" value="XM_018302039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8D6"/>
    <dbReference type="GeneID" id="28866146"/>
    <dbReference type="KEGG" id="chig:CH63R_07064"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07064"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="20165" checksum="371D6C74A0229DCA" modified="2016-11-02" version="1">MASRRPQFNQQVQVDTTPLPDDIPKVKEVGASSAPLLSASYFIGARCREYNDDFMQCKTENPGRGEFDCLKEGRRVTRCASSVLKDINTHCLEQFKAHWTCIENRNHQLYQCRPAEWKLNKCVYENLKLEKNIPNQRPGVTPVELRPHMIYADQAINTLEGKPFIPPSKAEGSKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8G4</accession>
    <name>A0A1B7Y8G4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotrophy-associated secreted protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156812.1">
        <property type="nucleotide sequence ID" value="XM_018302034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8G4"/>
    <dbReference type="GeneID" id="28866141"/>
    <dbReference type="KEGG" id="chig:CH63R_07059"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07059"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601422" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="97" mass="9873" checksum="EE36544A97CF30FC" modified="2016-11-02" version="1">MQFSTVLVTLLPALVAAETLSSSKLCVGGFRAGCLPSSDGIQRCLKDPNVGDTCVVDCQSQSDCYVQCVAQGFKNGFCTIDGSGPCICSGIDGGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8Y7</accession>
    <name>A0A1B7Y8Y7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156886.1">
        <property type="nucleotide sequence ID" value="XM_018302108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8Y7"/>
    <dbReference type="GeneID" id="28866215"/>
    <dbReference type="KEGG" id="chig:CH63R_07133"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07133"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="136" mass="15310" checksum="1F1A3BC13E9BAC54" modified="2016-11-02" version="1">MGRVRFDRILPPSVLAPIHLHKGCRCAVQLPEATESPSSPRQSWPTATHLTVPQTLLLPPNGAAAPRLLCSRVEHAKRVVVRLNQVHQRRGKRPDRHDVYNIPRRERRRSVAELDVNAEDFGRNLLPNRSIGQGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y919</accession>
    <name>A0A1B7Y919_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_07259</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157012.1">
        <property type="nucleotide sequence ID" value="XM_018302234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y919"/>
    <dbReference type="GeneID" id="28866341"/>
    <dbReference type="KEGG" id="chig:CH63R_07259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07259"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="384" mass="41115" checksum="6A1B36DDBDAAB200" modified="2016-11-02" version="1">MAPRQQQQQRARQQHLPSPPAPFTTRKLKILEQLSVPDAEYTDASPKGSVDVGILELIGELNALDGFVTTSSCAGRVSVFLEGRRAAPTSAPAGTAGVDDSHRRSATQSDDNDNGSTNTLTTIAGPGGKGGGGTWLFVSHDPVPKQHDGDDELLRLLGLVGEKGPAPPSVAGDSGSSQPGRRRKRLIHFKFEPMILHVLTASLAHAQLLLKCALAAGFRESGALNLLPATTAAPEDESSSPVTPMVGVRTMGLALESLIGYVDDDDDEVRHCTVTADYLRDLMQIANERFAENAARIARFRAALQEAAAGPPPKLGEGGAEWEDAAARRERKRAEGLRRKEEMLAARQETQTQTQSQSQPLLAESRETPSEDPAELPEYELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9Z6</accession>
    <name>A0A1B7Y9Z6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157431.1">
        <property type="nucleotide sequence ID" value="XM_018302653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9Z6"/>
    <dbReference type="GeneID" id="28866760"/>
    <dbReference type="KEGG" id="chig:CH63R_07678"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07678"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="220" mass="24506" checksum="8FF6E4A628758C48" modified="2016-11-02" version="1">MSNRALARDMQVEFQARTLIRIKFQAKQARREAQKAAKQDPILKKQIQDSDTDGGFIQLLKKGETAKAYQKAKMLLSKQALAQQMDQMADMAELSAAQIQANNSMNRMTHMMGQSSRTMSMAQKNMNPEKTLVTLEQFKQQNEEYAVSNGIYQDAISQSTSAQVSEDAVHELLGKLADDAGVQLNAELNSATPAKEELVSNEPTAEEEDALQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCC7</accession>
    <name>A0A1B7YCC7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Patched sphingolipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_08235</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157987.1">
        <property type="nucleotide sequence ID" value="XM_018303209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCC7"/>
    <dbReference type="GeneID" id="28867316"/>
    <dbReference type="KEGG" id="chig:CH63R_08235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08235"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601523" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1069"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1102"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1131"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1215"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="590"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1276" mass="140520" checksum="1C74E07040368B93" modified="2016-11-02" version="1">MPLWKLLGAGSLLLASLSSSASAEPFTPKHEAGRCAMRGHCGSKSFFGKQLPCPDNGLAEEPDEKLRQQIVDLCGAKWNSGPVCCDADQVKSLASELGTPNQIISSCPACKENFFNLFCTFTCSPDQSLFLNITKTQEKNKKTMVTELDQLISKDYGTGFFDSCKEVKFGPSNSRAIDFIGGGAKNYTQLLKFLGDEKVIGSPFQINFPAEYNEPGMSPRDLKSKKCNDEDPNYRCACVDCPSVCPELPAVSKPGECHVGLLPCLSFAAIFTYSILLFVAIAGVVGHVVWRRRARRESERLRLLQDASPSDDEDEGDLVQNGAMFDRPQRFYKINTWCDAAFSKLGHAAARYQGITIGVTLIVVIILSAGWVRFDLERDPARLWVSPASPAAKEKAFFDEQFGPFYRAEKMFLVNDQHSKEPAPVLSYDTLLWWMDVEKSVLQLKGPEFGATLDDICLKPTGNACVVQSVAAYFGNDPSLVGKNDWKDQLRQCAKSPVECRPEFGLPLEPNMILGGWKDDPVNATAITVTWVVQNAAEGSPAVERAMDWEIALRDRLLEVQQEAQERGLRLSFSTEISLEQELNKSTNTDAKIVVISYIIMFLYASLALGSTTLSFRDMIRNPAVALVQSKFSLGVVGILIVLMSISASIGLFSWFGLKATLIIAEVIPFIVLAVGVDNIFLIVHEFERVNVSHPDEMVEERIAKALGRMGPSILFSALTETVAFALGTFVGMPAVRNFAAYAAGAVFINAILQITLFVSVLAMNQIRVEDHRADCIPCLQVKSARVHLSGSNGNANARFYEVPEESWLQQFIRRTYAPAILAKKAKAIIIAVFLGLFAAGIALIPEVQLGLDQRVAIPDGSYLIPYFNDLYKYMETGPPVYFVTRDFNATARKNQREICARFTTCDQFSLANILEGERKRPEVSYISSPAASWIDDYFLWLNPDLGDSCCVENGKACFADRNPPWNITLSGMPQDGEFIHYLEKFLKAPTNDDCPLGGQASYGQAVVIDSEKDTIPASHFRTMHTPLRSQEDFINAMSAARRIASDITRTTGVEVFPYSLFYIFFDQYASIVSLTAALLGSAVAIIFVIASILLGSLMTALVVTVTVCMTVVDIIGAMAVFGVSLNAVSLVNLIICVGIGVEFCAHIARAFMFPSRTVMERAKNRFRGRDARAWTALVNVGSSVFSGITVTKLLGVFVLAFTRSKIFEIYYFRVWLALVVFAGTHALIFLPVALSLFGGEGYVDPESEGGIEEDLASRRYRALVPDEDTDSDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDV0</accession>
    <name>A0A1B7YDV0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158722.1">
        <property type="nucleotide sequence ID" value="XM_018300872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDV0"/>
    <dbReference type="GeneID" id="28864979"/>
    <dbReference type="KEGG" id="chig:CH63R_05897"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05897"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="270" mass="28971" checksum="8A1C8D1E1403F3CA" modified="2016-11-02" version="1">MASYLVTGASRGLGFEFLRQLSENPANTVIGLVRDLQSTKEKVSKELKRDNIHILQADLNNYEAIKNAVADVSKITGGSLDCLVANAAFISTWSSYDGIGVLGSDPKRLDEDLLGSFKTNVVGNVHLFNLFMPLVQQGTLKKIVTVSSGMSDLDFISKSGIEVAAPYSISKAAMNTAVAKFSAQYAQDGILFFSISPGVIDTGLYDNATDEEKQRGMAILVKMAKYAPHFTGPSTAESSVKSMLSVIEKASVEGGYGGSFISHHGNKEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEF4</accession>
    <name>A0A1B7YEF4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158932.1">
        <property type="nucleotide sequence ID" value="XM_018301082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEF4"/>
    <dbReference type="GeneID" id="28865189"/>
    <dbReference type="KEGG" id="chig:CH63R_06107"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06107"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="255" mass="28286" checksum="033B27D2515C474E" modified="2016-11-02" version="1">MAKESKDLLKMLEDMPTKEPDKSSWALAARKLRNVAQVCMAMKDCGDDEAALSRLEDKMSILGFIANASFAQCKGRRPERVDKLLISRYVWAAGLGDPSFDTMKKWKAVIDNGDPLDMNGTLSALQDAMPRPIKYCKVIFRPSSLVSQLSNKTISRATREDWAKTPADEWNWTPQNALHGIRLGPRGGARGAAAFVLPGTLLPLELRSFETGERIPDGHAFSITTGRRCPLAPSDHPHHADVLLYGSRNLARRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YES9</accession>
    <name>A0A1B7YES9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159002.1">
        <property type="nucleotide sequence ID" value="XM_018301152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YES9"/>
    <dbReference type="GeneID" id="28865259"/>
    <dbReference type="KEGG" id="chig:CH63R_06177"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06177"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="12"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="646" mass="72116" checksum="1E9C01433CDA3B83" modified="2016-11-02" version="1">MSAGGLEIFGAVGVSLQLVKAAGTCLSIVNEIRQISNLAHEQNNAHFELQVQALKFERWCATLSIQDILRRTEQGPSNSGLCKPTDQIQLKGAVESQLRLENPILVDLTTRALTDMKNDFAEATKIIMQYAGMSPPPEKIPSNTSLQVPKGGKQSRWDKMLRKEPKKQPSASLQAHSNVISRGGSSMALRTKWVTSDKGRVEALLKRIGHTNELLVVLLDTAHQAQVDRQTDMTILDLMDHDTLEGTTSRPELKTMAKIKQWQMQERRDSQTDDAVSAYSFSTISGANQTSRRIHSYQVRDFKRGSLPHGDYRTLTALEDKPVMVEWKYYNRDQPFRLEQTLRLGGLVGLLNKDELFKKFMTLPCKGLVDDADNSRIGVVFAVEGSAGNRLKSLQALIRETQVPVPIGQRFQLAKGLVTAVHHLHSVDWLHKSIRSDNIICSWAPESEIKIPSPSSRGKPAVVQENGGDGSGSGFGAAKASAARPRPRPLPPQYLVGWDLSRPDHPLELSETLSISTAGFQSRRDEILLYNHPSLHAQSASGKRPRYCARFDIYSLGLVLLEIGLWRTLSELRRHCNSDAEFRDKLPTEFCDKLLPRVGEVYWRAVRRCINGDFDDGSDGASETEGFQLQIAFERLVVSEIERCYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YET5</accession>
    <name>A0A1B7YET5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Impact protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159198.1">
        <property type="nucleotide sequence ID" value="XM_018301348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YET5"/>
    <dbReference type="GeneID" id="28865455"/>
    <dbReference type="KEGG" id="chig:CH63R_06373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06373"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF4">
        <property type="entry name" value="IMPACT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="551" mass="59664" checksum="FF873268B9B1E517" modified="2016-11-02" version="1">MASQQDLQELLRIITSRKGVSMMAAMGQVKALQARDLRSIKQISEAPFDVVESALGDSKAAKSLQTACKVHLKRPSTKRAGESLTADGDKRAKNRHDGSSAEAVCQSAEKLEDALALPIVTDEWEIAKALIYTNRAPIMLAFVVELLRCTMPLQPLSSRLSLAQAVVSANARTKAVDIGLANTSDNDASWGEGQPKVSIMGRLIAVLKRGDYQLAAEEVVAAPATFDGTSGAVPRMATKPSDAAVHKCAIAVSKSPWSISRQITFKSSTFVARVASVDNVGQASALTRSLLSSEPLLQTATHNAWGFRIQEQKHWGGVGEVRERCEDDGETGCGQFILRLMREASVTNVVVVLSRWFGGEMLGPDRWRLMRNVITEALSQRLRLPQSEVGAERVALWALDLQRLAGSGNVRSADDGNRTVTGAPIFRPESARSYLLKSFASSQNENDATSPGGENCLERSISRAGGGKLSKSEAEAEKLRNLGRLLGAFRLLFESWSDLTPPELNRRAFSWYAAIRPEVEPGIAGWGAKGCLRLSDILHLRRSNSEGSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFV5</accession>
    <name>A0A1B7YFV5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159379.1">
        <property type="nucleotide sequence ID" value="XM_018301529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFV5"/>
    <dbReference type="GeneID" id="28865636"/>
    <dbReference type="KEGG" id="chig:CH63R_06554"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06554"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1260" mass="140757" checksum="BEF32D6E61616EBF" modified="2016-11-02" version="1">MSSFNSTSRDAALSGDKRPWMHTIPRKPLSQTRITYTPVSNSLRYEEIDTQPEDAQGCEHPTQQEPSFSYSRFADANDVTRAETFKTNDTGFNSLFKSPVAVSVSGNGDGDGDGVDKVIVDRKATWRPQWLRPAVLTLFVCFFVLITAALAIMLHYSRRNNGLFQTGQSLVHVYVWRFGPTAIITVLSVLWARVELQAMMYVPWFALRRQQPDGRVTMSIDYLSMLSPAAFIRSIRERHYLVSLVTIVSVVLKVQIILAPGLFSFATVKTPASIGVRLQDSFARVLDDDVVKQTDTSAWYMGRALRNFDMLYPFGVTDEIAYQTFAPMNGKPRGTIDEPVTAVVDGFFTDLDCLQLAGYSISKQLQENSKLDIYVDLHFQGCDGPISLRHAGAILDPAKGNITYWAIKSNQTRACPGLRQDVPPFLYYSAVFVPTLANSSRIRFESAGAVLCEPRAWLSKVQVTDDGVAPRVALLQDQTRTPVLTNMWTLIEKSVPASQGQWDTEPTTTTYVKGPASAAKAFAGEVLQQGRKEDPTLYSNEAIYGSVMNLTRSLGPLLGHYRLRAKEDSAVTSFWYRNPATPLGNLVFLRDHPHVAAGISSRAAESRSWVRCSFTPMVLRTWARLSFGLYAFLLLGGLLLTLRLSTSSNGLATIEKEGYLHVAWTSLPALIALGVSLYISSCDWAYRDLGNLYRLSRKPCRSRELDLSLLDMMGLRALYHSVRLRLWSITCSQVLALVCGVLTSLASVLFTVEVTPKATTVQFQQNTVFRIRDDVEYSESYEIKQTEIATLLLQREANLTYPKNTFDDLVFPVFESMETLDVSRNLSVTINTPALKLQPSCLEVPREAYRLTFRNYTESGKTWFYSDYNEHTPCPSGDEVVNITAEFPLGEASLFGKAYAASDIKSIYNPANINFQCKLNDTSLKNYTTTLHYTYAWGEFSVARNDFDWFSVWRCNYTWAELDTQLNMIASDGEFVIDPENPPRPDYSSVRPLGSPLDLPPTERAPNGPFGMLPDIRISDKQSIGVASVFKPLVEPYGPLPKEALGDPNRVGEILGLLGHDVGFSVAQLANTENRRMIDDVLDTTSGALLLDATVVDRDRRRLVQDPNVTYFVVGILGAVILVNMWALASTVLRRRGSESWLLDMDVRGLAPDGWRSIASMAGLLRESNASAHLPPSTELLSQKELHGQMSDVSFRLGWFRRECDQTRHYTIGVMEDGEFNFMGVRRTVMREKNGFPDPGEGGWVDLGHDDVYELDISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGD0</accession>
    <name>A0A1B7YGD0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Alpha methylacyl-CoA racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159633.1">
        <property type="nucleotide sequence ID" value="XM_018301783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGD0"/>
    <dbReference type="GeneID" id="28865890"/>
    <dbReference type="KEGG" id="chig:CH63R_06808"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06808"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601628" evidence="2">
        <location>
            <begin position="18"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="619" mass="69147" checksum="1E7D3567AD1EDED8" modified="2016-11-02" version="1">MGPWLLVLRTILLGYRASIVVDLSTQHPLNQPPVRAATDTMGSKGEYSVPQEAEAVFQHGILSNPLMKDLPSDLKSLSQHVKFEGSPSPSVPINWKFAESISALKALEATMVNRLLQKKYNAAPVDVTINTDHASLFYFSPLIAQLIGKDGKFTPMALMNFVPEAMKMFPETDKHRTAASLHRALVTNMYKTKDGRCYEVHGGINPDPTFKALGLPEDGRADDTYDTVFERIQKVVSQMDSKDLDELLNEKAKQSGTVAMSSEEYFASEQGQANSKVGLFEINRDEKSSQPAAWWPENDKLPSSTKRPLAGLKIVDLTRIIAAPVVSRDLAEMGASVMRVTSSNITDMSSLHPDLNWGKWNCHLDLTKEEDKEKLRALIRDADVVVDGYRPGAMERHGFGRRDVFDLVKDRQRGIIHLRENCYGWHGPWQKRGGWQQISDACCGVSLAYGQAMGLDEAVTPVFPNSDYCAGVCGSTAVLDALMRRAEHGGSYGVDSTMQISLNYYSQWLVRSCGTYPEPVWKEVWERHGSPVFRHFHTMAQTVPLMSKLLQDHDTKTLFQPQFFEMRTSKAVDGTFWVVKPVLQFKNGAVEMRYNVGTRGNGVDEPVWPADLSVEVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGF2</accession>
    <name>A0A1B7YGF2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159653.1">
        <property type="nucleotide sequence ID" value="XM_018301803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGF2"/>
    <dbReference type="GeneID" id="28865910"/>
    <dbReference type="KEGG" id="chig:CH63R_06828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06828"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="331" mass="34675" checksum="0C08B9537CE8B116" modified="2016-11-02" version="1">MTDAIDTGSILPYHHAHTMPLYASSQPQGRMADNPQGTAGLGKSTILALLAHNPSHIYFSGRSLPSAEALIASVASSSSSSSGTATPPPLTFVQMDLASLASVRAAVAATFAHDRLDILVNNAGIMAGPAGLSADGYEVQFATNHLGHAMLVRALLPVLQRTAALPGSDVRVVTLTSLGYQGHPADGISFSTLRTTQAGPPFIGQWVRYGQSKLANILFTRELARRHPSITAVVVHPGVVGTGLVANQGLLNRLFVHATNRIAGASILTPEKGCWNQVWAAAAAGKGDLASGGFYMPVGHLADDQLDKCATDDRLAGELWRWTEDVLAGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGS4</accession>
    <name>A0A1B7YGS4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_06874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159699.1">
        <property type="nucleotide sequence ID" value="XM_018301849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGS4"/>
    <dbReference type="GeneID" id="28865956"/>
    <dbReference type="KEGG" id="chig:CH63R_06874"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06874"/>
    <dbReference type="OrthoDB" id="5428781at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601640" evidence="2">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="254" mass="27488" checksum="A487AC12B15B5FDD" modified="2016-11-02" version="1">MMIISLFTLALPLLWVPVSGLAVTNHPGPISARDLDDGNSSTADAVKFYFTTTLDPTASIESGNCTEIDGPPGDGDRALCIDCPCVIDREVAVEIREHGSWWTNWCHHRDAVNPDGVVLITQFKATTVTWTAGVGITLPMLGKAIKAKLGVSVETSKGVGTSIGCHGDHSWSGPHGVYFQEKMGWGNLKITETFTSSGGPQCSRRTNTRTSYGSSSWPDPDRTGFRQFQVGCRDPQNGNGPWCNFFADNLQHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH65</accession>
    <name>A0A1B7YH65_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serin endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_03618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159839.1">
        <property type="nucleotide sequence ID" value="XM_018298593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH65"/>
    <dbReference type="GeneID" id="28862700"/>
    <dbReference type="KEGG" id="chig:CH63R_03618"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03618"/>
    <dbReference type="OrthoDB" id="4803627at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="41"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="505"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="788" mass="84041" checksum="9DDA03B8C707ACEA" modified="2016-11-02" version="1">MVKLDPAPKKELDKRDATAVPIADIHKSTGVYRLHEAGILGEGVKVAVVDTGIYYGHSALGGGFGPGFKVEGGLDLIGDGYWPGEPKNPDNDIEDFQGHGTHVAGIVAGETEESENPLTRFKGVAPKATLYGYKVMGFIDYTDDETLIEAFLAAYDDDVDVITCSIGGADGWPDSAWQRVSDRIAATGIVITIAAGNSGWEGAYHGSSGSSAKGVFAVASTETPVIVGKPFNATFTDKAGASKTVTLGYMADEAFPETMNRPIVPLTLDLTSAVARGCQPFPPGTPSFANSIILLRSGGCQNLVKQRNARAFGADYVLTYNDESVLEIPFGYETATIGTISGDAGHEIIALIKDGGNVTGDFSLDQTRPIGIVSPYGNLANDFTSIGALNDLSIKPDIAAPGGNIYSTYLQMPTWTILSGTSMATPYVAGVAALYISKFGGKKVHGAKFSEQLMMRIISSGERVAWSHGIVTQDFTASVAQVGTGLVNASKVLDYTTQLSLERFALNDTANFAAQHTVAVTNNAAEVVTYSFSVEPAAGFDTLDASDPNRLAKYPLAPQIMVPEVALPEDGFSVGPGETKTAEFTFKVPEGLNARLLPTYSGSIAVKSSKGESLAIPYLGLAANLQKEMHETFEVGYPLATKGPDGSITLDPTNSITFTFDLSTAAQDFPRVAYEVKWGVKTLRWDIFEDGWDESAWTSYPPVVGENGYVGTATGYRRTTDQANFDPARDSKNRTVAFPLVNIFRTSIETPRHIVWWLGGLGDGTDIKPGNYTQVPSPPRIVRLPLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH85</accession>
    <name>A0A1B7YH85_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159954.1">
        <property type="nucleotide sequence ID" value="XM_018298708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH85"/>
    <dbReference type="GeneID" id="28862815"/>
    <dbReference type="KEGG" id="chig:CH63R_03733"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03733"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="223" mass="24083" checksum="F936145CFCC64630" modified="2016-11-02" version="1">MSDTSPLADIDWVEVGTGKHAKKNPLLSWPTTPGQAHMHEPATTRSVAKHGLGYTNQLTNRPSGKGGIRHRAPMAGIEFRMTMQTRVEAGMKGALATCFASPMAFNHRHFVPSALNREKRLRKTAFQDWKPSKMTRLHVSWLMAHGSMSRALRTSAPPSAVGTCRSTALGAPLAGHPVDAKSNDSSLHPLLRCDQTTTDALCTGRHTSQSICGADIPSLQTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI09</accession>
    <name>A0A1B7YI09_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160119.1">
        <property type="nucleotide sequence ID" value="XM_018298873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI09"/>
    <dbReference type="GeneID" id="28862980"/>
    <dbReference type="KEGG" id="chig:CH63R_03898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03898"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="93"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="367" mass="40586" checksum="186D39837AF3A06E" modified="2016-11-02" version="1">MAHILRAWSAAVLRDIGLQSTNTRLRVVDLLARSGAVSPVWSENTSDAAPDQQPLLRQRNLSHVGDSGSEEFVLSDGRKLGVAYYGARNGHHAVFYLHGYPGCRLSGGAFFDAPGVRLGARIIAVERPGIGNSSPQPGRRMLDHADDIRELAEHLNLQSYGVIGVSGGGPYALACAYSLPEENLKGVSVIGGMGPIDVGTKGMNWGNWLTFKGLMYFPAIIRWLQTKVMAVLNSVSNEKMVELVRDGLSKKSYSWASPDLPTLRDPEILTIMLDSYREHYKQGVDGHMEDGRVLTSDWGFRLEDMRSSIPIQLWYSKKDTNVPFRMGEAIASRLSSPPDFYVKEDETHLNLVLKYSADALERLLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIB4</accession>
    <name>A0A1B7YIB4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160217.1">
        <property type="nucleotide sequence ID" value="XM_018298971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIB4"/>
    <dbReference type="GeneID" id="28863078"/>
    <dbReference type="KEGG" id="chig:CH63R_03996"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03996"/>
    <dbReference type="OrthoDB" id="4848573at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="794" mass="90741" checksum="CE288AC289D70E26" modified="2016-11-02" version="1">MGNTTSRLLDNKLTHVLPATVDVEATSADGIAVIMKQLLSQTSMRDVDSLTAESASVRAIFQRNKLEILRNLIAPEAWDDAIACVDRRLRMGKAARRAFDEDYENGTVSSFPSDDPLSEGGSGSGGDNSGKGGVKDGRSANTSPATPTKEGRRHPRPTDRGQWDLDDLCNLVRIIERLLRRERHNTYPSFAEWEASWKSPWPRRDVHAYRPVSSRQGADWTVRDHDGREHHYEELCRDHCTEDPENFDYAFQRHTNLDQDGVPYEGVTVNSTTGPRLQRALFRLELLRRAHYQRPLLPRGARFASRTRTVREGVFGVAGETYGTRRARAAAFFRGWAADDFLEAVCAFKATLNEYAVPVSEMMEDFMVAVDETFETPEQLRVDRVCEDIKTDFREVTERAAGLRWVKDPSTGEESLCIVDGPTESDEEPDDAQSLGVMHDHAEPDEELYATRAELLDDKEELDIFTASLMVPFDRFEFDDLRSTIFRSERCRATSRHKRQREHPSLRPSLRETSPDEAMSRFLHVLCSLPLAFLGEFMVMPTSRQRDFLKASYWALSRVKASHTPLFLSGEMSAWSSRPPGGVDGPDRDLGAAHDARLFPALSVRAAAIACVCDVYVFQEHPSMGFRVLADSQDDDGGGGGGCGWRWRWTGERMAPVLWERLRSEMRFEDFDIDGVFRMSPESWAAVWRSDRELERQLWTGPKAETERWEGYRRAAAGRRDPDECYCRLGDRCALCLPLPDVKHPERDLFTKEEWEEEKRDEREDMRPFRLRKRHPGLAMSIREYRKTHKAVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIJ1</accession>
    <name>A0A1B7YIJ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_04098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160319.1">
        <property type="nucleotide sequence ID" value="XM_018299073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIJ1"/>
    <dbReference type="GeneID" id="28863180"/>
    <dbReference type="KEGG" id="chig:CH63R_04098"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04098"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="96"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="192"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="427" mass="46476" checksum="3471C23C0F40335E" modified="2016-11-02" version="1">MVFLSRSIRSVASSAWGLQTSSKASSLARPAFSRAAGTPSALARKLPGQLNSIRTLTTTRQNQVKVLAVLYDGGQHAKDVPGLLGTTENELGIRKWLEDQGHTLVTTSDKDGENSKFDQELVDAEIIITTPFHPGYLTAERLAKAKNLKLAVTAGIGSDHVDLNAANKTNGGVTVAEVTGSNVVSVAEHVVMTILVLIRNFVPAHEQVERGDWNVAAVAKQEYDLEGKTVGTVAIGRIGERVLRRLKAFDCKELLYYDYQPLSPEKEKEIGCRRVENLEEMLAQCDVVTINAPLHEKTRGLFNKDLISKMKKGSYLINTARGAIIVKEDVAEALKSGHLAGYGGDVWFPQPAPADHPLRTAKNPFGGGNAMVPHMSGTSLDAQKRYADGTKAIIDSYLSGREDYKPEDLIVHKGDYATKAYGQREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJH1</accession>
    <name>A0A1B7YJH1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160515.1">
        <property type="nucleotide sequence ID" value="XM_018299269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJH1"/>
    <dbReference type="GeneID" id="28863376"/>
    <dbReference type="KEGG" id="chig:CH63R_04294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04294"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="891" mass="100921" checksum="0FCE04049EFE9940" modified="2016-11-02" version="1">MASADILSQTLHTITSVKLKQLDKQKASYESGKRALLDDAAYETDHRKRAKLLVDGSEKLPAMNSLDDSSLVSVDNLRRFVQQADYDPCVSDDLLDGYEKAMRNELDVQSARYRYAELYGKLVNEWITAGKAADEPHGFVPVGREEMHRQRATWEQYVFRAKETDSNAIKSYLGQLFITSTKDIHRAFAELRGRIAKFQAGWDKRTHFDETSLKNTIRGLLRTDILTDQKRTTLNDFLRNDVVLSEIADVLNMRMQTRQTWAWDGATVVEQRRQLNGRYRFYPDEDLLQAIFVHHVGKQWAVEMRDVLVSFVQAPGVDKDATKRIGKEELRRMRFFTGETMPVESTQSVVNQLSAHYRNEVFLDQLPSCVAEKRGGYGSDGERKADDTRNSHVAVVQNLLHLVQSEIILAKRLGYDITVIRSDLKWFGPSVPHSSIFAVLGFFGVDAEWIDLFRRILECPMRFAQDAPDAPAHIRRRGTPLSTPLADFVAETMLFCMDFAVNQRADGCRLYRLHDDMWLWGGLETCVRAWETMTEFVELAGLEFNEDKTGSARIVAGGGGGGRPGGREASQQQRLPLPPPPPLAEGLPKGDVVWGFLKLDAASGRFLLDQAKIDVHIEELRLQLGACRSVFDWIQAWNIYGARFFRTNCARVANCFSRAHVDSMLATFHRIQARLFGEGGAGAHLKRLIGEKFGIVDVPDGYLYFPVSLGGLGLENPFVHLYLIRDGVTADPDRIVDEFLAEEAAQYRLLKAAFENAEADTATTTTTTTMQLALHHPWRAYDYNDLRNEPFMSFDEFSRHRRRTSTALGQALERLRTMPKARTVGLTGELEAALKTTPAGWYGLSDYERWVCALYGRDMIARFGSLTVVDKGVLPTGLLDMLRQSRFKWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJH3</accession>
    <name>A0A1B7YJH3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_04523</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160744.1">
        <property type="nucleotide sequence ID" value="XM_018299498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJH3"/>
    <dbReference type="GeneID" id="28863605"/>
    <dbReference type="KEGG" id="chig:CH63R_04523"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04523"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="719" mass="79912" checksum="F2C73832655E041E" modified="2016-11-02" version="1">MAVSSRAGFLAVAVVFHLVYIYSIFDIYFVSPIVSGMKLVQIDRPDHVKAPADRLVLFVGDGLRADKAFQFFPEPYPESEGDLAPRPLAPFLRSRVLEHGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVATGWKLNPVNFDSVFNRSRHTWSWGSPDILPMFQEGAVPGRVDSYTYGHEFEDFSQDALQLDYWVFDHVKELFTEAAKNETLDAALRQDKVVFFLHLLGLDTNGHSYRPYSKEYLNNIKVVDQGVKEITALIEKFYADDRTAFVFTADHGMSDWGSHGDGHPNNTRTPLITWGSGIAPPVLASDSVAPGHDEYSSDWNLDGVKRHDVAQADIAALMAYLIGVEFPANSVGELPLSYVSSSIDEKAQAALVNAREILEMYRVKEERKRATELRYRPFRPLSDTDLTPSRRVEDIQRLIDAGNYEEAIEESAALVKIALEGLRYLQTYDWLFLRTLITIGYLGWMAFALTVVVGLHVLRGSHPPSHTTTGTTVFTSILAALYASFIVSKSPVTYYAYGFFPVVFWEEVWARRGSLAQGRHVLFGHIKTGGGVASFLLNVVVYIGVIVSLALGYIHREVLTVIYVFAAFWPMTYGLRFLHTNTLLSVIWFVSCLVMSVFTLLPAMKSEDIPLIVAGGSVMAVIGLAYLVWEERLLARPALPTARALTGIQVGLILLAIVVTRSSTLSLQAKLGLPRGNQVVGWIVLGKRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJM8</accession>
    <name>A0A1B7YJM8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_04526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160747.1">
        <property type="nucleotide sequence ID" value="XM_018299501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJM8"/>
    <dbReference type="GeneID" id="28863608"/>
    <dbReference type="KEGG" id="chig:CH63R_04526"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04526"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="319" mass="35311" checksum="8F26B8F1409AEB63" modified="2016-11-02" version="1">MPICIECRHPVKTLWTKYSNADDKSSGHNIRLTVCRNCGHFCDKYVEHDFVVLFIDLVLIKPQVYRHLLHNTLMKDDDQFDSSIVRLGVLLLLFDVYLTWARIEKQTVPKSSQYEGANLGSLTQQSIVSQYLFFCMLDGKSNFFPPKQRTITVPGPPQAQANIAPVILCALSTLAFHMSIRFMTSSPFSPLGMFNVLPRYSRPNSVSTALLVSSSTKLFPILMVIWQYDVPAAARSLGWAVVANNVEALRILLDCGYGVATLLATTGALARWAVGRSVLWAAGMDGIDSIGETSIAADGKALWALLMYVREWASDLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJT3</accession>
    <name>A0A1B7YJT3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SNF2 family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_04404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160625.1">
        <property type="nucleotide sequence ID" value="XM_018299379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJT3"/>
    <dbReference type="GeneID" id="28863486"/>
    <dbReference type="KEGG" id="chig:CH63R_04404"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04404"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18070">
        <property type="entry name" value="DEXQc_SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000059">
        <property type="entry name" value="SNF2 family helicase/ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="114"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="913"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1241" mass="140087" checksum="33A2C7A9A60C201A" modified="2016-11-02" version="1">MRPKRESWSPLDFYEAAHVPAADDQTALSIEIPELSATLYPYQKKTIQWLLKREGVCWNVSGPDSVSSIEDLPAPQDADGAYSFRKVRDPLATGRPLYVSHLYHAITTDLAPFQHAEQSVRGGILAEEMGLGKTIEIIGLITLHRRSLTEKVVYTGEGEELLTTGATLIVTPDSLRQQWMEELERHAPHLKVRYYPGRKHVKTDAEEELRVDLASQDVVITTYPILSAEVHFAMKPPERSRRQERKYERLESPLTKISWWRVCLDEAQMIESGVTGAAAVARVLPRINAWGVTGTPVKNDVKDLYGLLEFLRYEPYASSAQVWRALTESHKTLFRSLFESIALRHTKQLVRHEIAVPPQKRFVITLPFTAVEEQYYGEMFKKMARRCGMNTLGAPLQTKWTLEDYENEMRTWLNRLRQSALHPEIVQRRTTGRKVGPMRTVEEVLDAMIEQSDNDIRNDHRAYLQTRLTHGQMLENSPRVKEALEIWETVKESAAVLVVECRQELKLVLEELSAMGKSAASVSALSTRDDASASVYDDEGEADDGTSNPRVGEARAKLRHALEVLHKATFFCANAIFQIKSNSDMTEPDSDEFKKLQQLEDAEYGKAQDIRREILSDGHDRAMSLIEKLGRQAHNQTFVEIPELVYTEMKGLESGPPLEMLERLHGILNEQANRIDEWRETVIQLLCQALIDQESEVEVTGEEFMDSTKIQEELIVHVQVLRAAIADRQEAISGLENQLIKHETRVSLAAAENGDGPAPEKLLALYRLRDEVKPSPDDYGSLRRVVSDLRAVASRLPKDGTGGRASTEGEIVHRHIRATQAHITSQTKVATALEREVDRFTSAMNARVEYYRQLQAVSDSVAPYEGPNDDQAIAACVTSEERHQIKLGSAKAKHRYLLNLKKEGGQSNEPRWCIICQTYFTTGILTICGHEFCRDCLKHWYRAHHNCPMCKRKLRPTELHDITLKPRELKLHEDSLHADTATGMLPEANKNQVARTSGIYSHFSADKLAQINDIELASLSFGTKIDTLVRHILWLRESDPGAKSIIFTQFRSFLEILGAAFDLYKIGFSTIDRPNGITRFKGDPGIECFMLHGRANSSGLNLVNASHVFLCEPLLNTALELQAIARVDRIGQKNETTVWLYLIEGSVEESIYNLSVKRRIDHMGQSSKAKSKDSTPEIQEPTLEAANTLELEQASLNRLMSRDKNAGEAVAAEDLWECLFGQVSQRITADVTDGIIEEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YK52</accession>
    <name>A0A1B7YK52_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160970.1">
        <property type="nucleotide sequence ID" value="XM_018299724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YK52"/>
    <dbReference type="GeneID" id="28863831"/>
    <dbReference type="KEGG" id="chig:CH63R_04749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04749"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16561" checksum="1550D39F9E8DDF20" modified="2016-11-02" version="1">MTSSTADPYRIVTAEPARYGLFRSAFPSPHNLGAQYETLPRTLPSPNLAGAGAWPRWKPKVVQCLSLYGVYPCTFLYDRNFLTPLVSVSSDKATHPPAPPPLDKTDGILPVGEEERLKRDGRQFNRAYLPGRYRSREPPTKAECEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YK82</accession>
    <name>A0A1B7YK82_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160994.1">
        <property type="nucleotide sequence ID" value="XM_018299748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YK82"/>
    <dbReference type="GeneID" id="28863855"/>
    <dbReference type="KEGG" id="chig:CH63R_04773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04773"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="81" mass="9072" checksum="AE452089F03AED77" modified="2016-11-02" version="1">MRGQRPCQCNCSPWGKGGELAGKRAGTDAPLYENTRWSRTNFPGSFDPLSRIRPPMFSIFCRQFDPLRYGIAFPVTSTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKL7</accession>
    <name>A0A1B7YKL7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161128.1">
        <property type="nucleotide sequence ID" value="XM_018299882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKL7"/>
    <dbReference type="GeneID" id="28863989"/>
    <dbReference type="KEGG" id="chig:CH63R_04907"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04907"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="36075" checksum="0647614F6293669E" modified="2016-11-02" version="1">MLWTCGNTSLRALRSTISSLRSSSSSSSSSSSTARVPSLTLGILFSRTTTTPPAVHARTMSAAAASLVESAKKAAAYRAVDEHLAPSARFVGIGSGSTVVYVVDAIAAKGPAFHAAMTFLPTGSQSKGLIRAAGLRLCNLDERPLGPDGKLVPIDVAFDGADEVDADLNCIKGGGACLFQEKLVAIAAKKFVVVADYRKLSSRLLTNWKAIPIEVLPMSAPDVLDRLTALGSVKPLVRPGAPGKAGEVVTDNGMWLIDAPFPKLLLPQDLADADPSSRQLGRDAAGAWEVSALARELLMIPGIVEIGIFHGLDGLQAARAGKEGLAQKPVAAYFGMEDGSVKVAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMR1</accession>
    <name>A0A1B7YMR1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161872.1">
        <property type="nucleotide sequence ID" value="XM_018297056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMR1"/>
    <dbReference type="GeneID" id="28861163"/>
    <dbReference type="KEGG" id="chig:CH63R_02081"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02081"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="124" mass="13535" checksum="2C6D06DB2E0DBCA8" modified="2016-11-02" version="1">MSESPSVDSDTAAPTPLILDDIDAQAPDFGKEALFLLKKLEIVTMHFEADRRVKEAKRLSAAGEIENLRQEVAGLKLKIANLQEETTITKMKVRAMECWAAGLKHAAQAPHFGPDVNDGKPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YN05</accession>
    <name>A0A1B7YN05_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_02146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161937.1">
        <property type="nucleotide sequence ID" value="XM_018297121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YN05"/>
    <dbReference type="GeneID" id="28861228"/>
    <dbReference type="KEGG" id="chig:CH63R_02146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02146"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="342" mass="37992" checksum="59FCAEFE23DBA641" modified="2016-11-02" version="1">METALKSWELDNNVKLVDPKRDALYNLDLDAQKEAMNARPWALNPNHFKNVRISAVALIKMVMHARSGGNLEVMGLMQGYVNGDTFIVTDAFRLPVEGTETRVNAQGDAEEYMVEYLSLCREQGRMENVVGWYHSHPGYGCWLSGIDVGTQALQQQFQEPFLAVVIDPDRTINAGKVEIGAFRTYPENYVKEKEGGGGAVTSDGWQEVPLAKAAEFGAHASKYYSLEVSHFKSTLESHLLELLWHKYWVQTLSQSPLITNRDYGNKQMLDLASRIKETTTQVARQARGASGPNAHIVGTRKVDGLIAKLVKDSNTVATQERTGLVSMEVKKKIFNDVGANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP00</accession>
    <name>A0A1B7YP00_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162312.1">
        <property type="nucleotide sequence ID" value="XM_018297496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP00"/>
    <dbReference type="GeneID" id="28861603"/>
    <dbReference type="KEGG" id="chig:CH63R_02521"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02521"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001401">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="500"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="826" mass="89674" checksum="1A245169E381C372" modified="2016-11-02" version="1">MKLVLVQVLGDVRTRSITARSNTEASSDTDKGAILSPAWLTATKAQIKLALATVLKLRTHGSKDVREALLTLCLGLLDECHISLGNCSSVLVETAMVLSPTDQTSSIAVTSLHDLAIIYSELGETVKVTCYNWVTSLPRIMQSADEGKKQTAVQNLMRGMSLVGSLQLDSSLLDESIAAALRDSVTSLVTGVTPGKVSDQTSTDASWYSQDVMLAGETSRKYQHVLLGQESQLGTRLAMLDLLSNVGPASQQTKLAAEMLDFARDSTGEMQTSSFWLSFELLKAALSRSSDLEDLLDFSSLGPGGDVADSVFQELYSFAVVLLDSYSELSEIDWRLEATALEVASFAASRSGEAFRPELIDVLYPITTFLGSSNLQLREHAITTLNILAASCGYTSVSELIIENVDYMINSISLRLNTFDISPASMKVLIMMTRLTGPRLLPYLDDVVASVFAALDNYHGYPMFVESLFAVLKEIVSQGAKSDKLLLEGRQNGPESHRKVASGSVAVEDIVRLLERRREREDAVSAADANLEDAGGHPQIPWGPGKGKAKAGLEDDEGAAGNEVDKERPAKTPTYTLLERITGLTQHYLTSPSPTLRKSLLDLLVTVSPALSGDEDSFLPLINAVWPVVINRLYDEEAFVAISACDALSALCATAGDFLSSRIKTEWWDGLGKWCRTKKLEADRSQGRSRTRQESSKAGWSKAPTSQEIVIPIRSGGDLLGRQSAEMSNSSSPGGLGRFAQAAQVWEAVTRLLVAIVSHVRLESEVFREILELLTEIISQNAEARQALEAVNADAVWLVLYQRGHVKPMKTPKLEGYNFPPMTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQF5</accession>
    <name>A0A1B7YQF5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aga1 a-agglutinin anchor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162645.1">
        <property type="nucleotide sequence ID" value="XM_018297829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQF5"/>
    <dbReference type="GeneID" id="28861936"/>
    <dbReference type="KEGG" id="chig:CH63R_02854"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02854"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="44062" checksum="EC67C3160C0D68A2" modified="2016-11-02" version="1">MSSSLARTRSLRKPTQGSSTDLPPTSTSNSNSTSTVNTAAAAPAPAPPTTSTQRPVSPSRLPAPRSLAATRPTTRSVSGASVASTKSGASDAAAAAAKKKRANPLSTLLSRPASTRQTPGTTSATRPRDAAAAAAAAAGGPPSAPPSRTNALSGLTRPSSTREPAPTRPRHPPAPSSSSSSTPAGAATGTRSTTATTRPTTSGGVPSSKLTSAASSATSSPTKGHARARSVATLNGSTILRPPGQPSASDRTTRSRPTSLYGGKHHRLVRAFERWASALPDLEAARARAEDQGDPEALLDADSQVRFGGALDARWKEDAAALVRKLEGWRAQLRELEYRDEEESDDDGGDGDGGKTRVSSRSSLERLLDGCGSLIKDMLDELAVMEEIEAVAVEREAEWIRRMNRQGEDGRGKDTPRAGAVWRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRB3</accession>
    <name>A0A1B7YRB3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163102.1">
        <property type="nucleotide sequence ID" value="XM_018298286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRB3"/>
    <dbReference type="GeneID" id="28862393"/>
    <dbReference type="KEGG" id="chig:CH63R_03311"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03311"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25333" checksum="ACCEC0E8CF8ACEF3" modified="2016-11-02" version="1">MNRKGAKNEDEIPSGGGGGGGGGVNNNKGTLADCINAVSSCEDKAKEGGINTTMREGMLVAFNLHNIILQDVDENDAKDVVDDNAFARENFMARAKGKCHCDCCRKSLVRFLEIDILGQYLDSLRKHIDEKVPGWAYQSLEMFPFLSHDEGIHLVRSLVLFRSSAPTTVHHPQGVRRNGTLLKWSSMFSKGAARFDSRMRLVRFRPLLLNKLAFLGLVAAPEGLLSGDQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRF5</accession>
    <name>A0A1B7YRF5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CH63R_03194</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162985.1">
        <property type="nucleotide sequence ID" value="XM_018298169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRF5"/>
    <dbReference type="GeneID" id="28862276"/>
    <dbReference type="KEGG" id="chig:CH63R_03194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03194"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="180"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="507"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OBR14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="591" mass="67228" checksum="72F465F12AA5C3C8" modified="2016-11-02" version="1">MHNIDRRLKQRAASSTRQDQASERQDTTQVPVPARQDHITPRRPPTMASNESPAAPHEPPYTYRPNQGYDQTESIPVELRTVPNDASAHEDEDDGDLEDIFGEDEEIDDEDWSADSGNLTKSYNRQRMFNTTDSALPRSNAQRPAANTKSSVDDQITALSKHAAKIRLDGVKENDEKSKDKADRATSEQVLDQRTRMILLQMINRGIVSEIHGAISTGKEANVYHAILHPEGDGPNIQRAIKVYKTSILVFKDRERYITGEHRFQKGFDKSSNRKMVKLWAEKEFRNLRRIHAAGIPCPEPISLKLHVLAMGFLGDKRGWAYPRLRDANLTGDDVDQQWRNLYVQLLGLMRRIYQVCRLVHADLSEYNILYNSGKLYIIDVSQSVEPDHPRALEFLRMDIKNVGDFFRRKGVDTLSDRAIFDFVSSPEGPVEEPALGEALEKLYESRPADNEEAAAEQEVDNEVFRKQYIPQTLEQVYDIEKDGAKIGQGEGDKLVYKNLLADAVVKEDEEQEAEDETSDDESGSGASLASGEEDDSRFDKGRPRGRKHEDKEEKKQHKLAVKEAKREKRKEKIPKSVKKKLVSSSSRKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRG0</accession>
    <name>A0A1B7YRG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163144.1">
        <property type="nucleotide sequence ID" value="XM_018298328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRG0"/>
    <dbReference type="GeneID" id="28862435"/>
    <dbReference type="KEGG" id="chig:CH63R_03353"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03353"/>
    <dbReference type="OrthoDB" id="4799509at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="252" mass="28893" checksum="E619B3C718FD14FF" modified="2016-11-02" version="1">MAPRSSGADNQSAQAPKLTPYHHRSKTNAPKYVTFYHITDEAELWFGQSSKNKRELTLDEYRDELERVPDEEIYPKIPTDIELTIAPENIDCPVYIKRPGLNCYETMKGTPFVPKAVLDETLILEKIFKTQHLNIVEYYGCQTKRGRITCIVLKQYDYTLSQYIHQPAFQHLDKARFLEALDSAVAFIHSLGLAHNDTNPDNITIGEDGLLVLLDFGSCAPYGHKLQSLVTRGWYEKLFFTSEKEHDDFATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSC1</accession>
    <name>A0A1B7YSC1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163371.1">
        <property type="nucleotide sequence ID" value="XM_018295009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSC1"/>
    <dbReference type="GeneID" id="28859116"/>
    <dbReference type="KEGG" id="chig:CH63R_00034"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00034"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447799" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="387" mass="43222" checksum="DF5FFB2C88E31A2C" modified="2016-11-02" version="1">MIARRLLSLLSLTALAMAAPAAEAINQGDEKPFFYKGHDLSSLKMLEESQNVFVDTARGNQERPADDILADGGMNGVRLRLWVDPPDGTYGLNYTIDLAKRFQAKGQRIFLDFHFSDSWADPQKQPAPAAWPTELEPLAGRLREYVRETLVAFRDAGVTLDIVSLGNEIRHGMIWPLGRVSVDVQPWSATVANFSNIATLYKAARAGVKDATCAGVPKPEVMLHLDNGWNLTLQERWYGALVDNGVPLSAWDSFGFSFYPFYGTSATFANLREVLRVMADKYNKPMQVVETDYPAVCDGRWNPIPESSEPSIPYSVAGQIQWMAEVIRIVREAPRGLGRGVWYWESPWLNNTSLGSDCNDAILFEADYSAWPRTVGYSRESVNVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSU0</accession>
    <name>A0A1B7YSU0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">14-alpha sterol demethylase Cyp51A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_00204</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163541.1">
        <property type="nucleotide sequence ID" value="XM_018295179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSU0"/>
    <dbReference type="GeneID" id="28859286"/>
    <dbReference type="KEGG" id="chig:CH63R_00204"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00204"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="523" mass="58328" checksum="9C74B7D3825A66C7" modified="2016-11-02" version="1">MSTLLETIQPVSTASIAVYGFIGLVALILFNACQQVVFRSKTEPPVVFHWIPYIGNAVSYGMDPVAFFIKHRKKHGDVFTFTLFGRKMTCYLGIEGNDFILNGRLQDVNAEEIYGPLTIPVFGQDVIYDCPNSKLMEQKKFVKFGLMQRALESHVPLIEKEVVDYIETSPAWKGASGVVDVSAAMSEVTLFTAARSLQGEEVRKKLTAEFAELYHDLDMVSPGFTPINFLFPRLPLPRNRRRDAAHAKMKAVYEGIIKQRRETGLGAEAEHDMLWNLMSSSYKNGTPVPDSEIACMMITLLMGGQHSSSSASAWIMLRLAAHPDIAEELYEEQARNLGEGDRGLRLPPLQYADLDKLPLLRNVVKETLRLHGSIHSILRKVKNPLHIPGSPYVVGTDKVLLASPMVTAMSDEFFPDAGSWDPHRWDEPLAGEGAVDVDDTVDYGYGAVSKGTKSPYIPFGAGRHRCIGEKFAYLNLGVIIATIVRNFKLETMDGRHGVVPPTDHSSMFARPMQPSKIRWTRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSX9</accession>
    <name>A0A1B7YSX9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Het and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163672.1">
        <property type="nucleotide sequence ID" value="XM_018295310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSX9"/>
    <dbReference type="GeneID" id="28859417"/>
    <dbReference type="KEGG" id="chig:CH63R_00335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00335"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="448" mass="49538" checksum="7D336951AED6C82F" modified="2016-11-02" version="1">MLFWSHIALVADGLVAPEGRRLRRSWPGPACCSTTVAFLSRHLAGAHADWLIAQSTAEWISKVYRFYTTSVSLSDQCPTTEQVTTRAPAGTSSNRVEKRQNAKTKAGLKGSAKSKGIGKAAAAKSRLPLEDRKDDDDESEDGHDSDTGAHPEGSRSTEARLMACPYYKMDPIQHYRCVEKHKLDGFNRLKQHIERCHSTTLYYCALCWVKFKDAEARDGHMRSGGCEPIAGPEDFTGDEINRLQNNLPRGWPDHDKWYWVWDNFFAAHPRPESPYVYEGIREPLSLLTSIAKRNANSQEFGDWLMARLRMPFSEYSTLWDDIIGQLLTLCHEHTPLSRQSPPPPPSANAPPTAMTHAALYSHGGSGSMSFFPRPYSTIEPIPHDGWAQPLQMNTPSASQAAPGPGNPGRNGSSTGATPGHDDWNIAAGGTQSTDEAAPDPMDEFMDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTB5</accession>
    <name>A0A1B7YTB5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vesicular amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_00374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163711.1">
        <property type="nucleotide sequence ID" value="XM_018295349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTB5"/>
    <dbReference type="GeneID" id="28859456"/>
    <dbReference type="KEGG" id="chig:CH63R_00374"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00374"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="7"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="462" mass="48058" checksum="3B3E2BB541FA9CC3" modified="2016-11-02" version="1">MAMASAAAPAPKRAPFLFAYRSSVAFIIITVAFAVFTDVFLYGVIVPVVPFALESRVDIAGGQVYGAALLVSSPIWGYLADRISSRRMPMVAGLLLLGGATALLCAGTSIPLLVVGRLLQGASAALVWTVGLALIVDATSSENMGKAMGWVGMAMSAGILSSPMLGGLVYSAGGYYAVFAMCFGLIAVDTAMRLMAIDVKTARAWLEEAPTPADGGIALDDERRHADDGQNGTAEPTLRGGKATSRSKPAFLTLLRSPRLLAALWGTLVHGIVTTSFDSTLPLFVSETFDWDSVGAGLIFLPLVTPSLLGPLVGAACDRWGARPLSSVGFLVATPFLICLRFVGSDGLSQKAILCVLLVGVGVAMALVLGPLMAEITWVVEDVMPTSAQSSYAQAYGLYNMAFSGGALLGPIIGGMIRDAAGWGTVGWTLGLVTFVTSVTQVVWIGGPLIRHRMSDEAGTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>H1UUZ1</accession>
    <name>H1UUZ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_00708</name>
        <name evidence="15" type="ORF">CH63R_11927</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11"/>
    <dbReference type="EMBL" id="CACQ02000111">
        <property type="protein sequence ID" value="CCF31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153742.1">
        <property type="nucleotide sequence ID" value="XM_018306901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UUZ1"/>
    <dbReference type="STRING" id="759273.H1UUZ1"/>
    <dbReference type="MEROPS" id="C85.007"/>
    <dbReference type="GeneID" id="28871008"/>
    <dbReference type="KEGG" id="chig:CH63R_11927"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11927"/>
    <dbReference type="eggNOG" id="KOG3288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049327_0_0_1"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000016">
        <property type="entry name" value="Putative ubiquitin thioesterase otu1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="13">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR05224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="387" mass="42032" checksum="026802541D9AEA70" modified="2012-03-21" version="1">MRARYKGPGGTGVVSLEDTATVGDLFNEIKDKTGIADFNLKYGWPLQTLTLGQKDVNAKDLGLNGQSFSIEPAQPRAITPPPAALPVASRGVEAGGPAVKKARLDSDADATPSDISIPWPERESTLLLRVMPDDNSCLFTAFGGAIPGKQLEAKELRKMVADYIRQHPDDYPEAVLDMPVEKYIRTIQDPERWGGAIELGIFSDLFDLEVVAFDVKSQSPLRFGENKDSRCILVYSGIHYDRIACSPSEPPYTHSDLPPELDRTNWSTSDDEILDKTRALIRKLHEMHYFTDTTEFLLRCTVPGCDWLGSGQNEANKHAKASGHSGFSEIKDEPSGHGAAGAAAGFGDSALRKCNAPGCEWLGTGLTEASIHTGETGHTSMAEIPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWL2</accession>
    <name>H1UWL2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-dependent formaldehyde-activating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04767</name>
        <name evidence="6" type="ORF">CH63R_10256</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000401">
        <property type="protein sequence ID" value="CCF32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154654.1">
        <property type="nucleotide sequence ID" value="XM_018305230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWL2"/>
    <dbReference type="STRING" id="759273.H1UWL2"/>
    <dbReference type="GeneID" id="28869337"/>
    <dbReference type="KEGG" id="chig:CH63R_10256"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10256"/>
    <dbReference type="eggNOG" id="ENOG502SYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_7_0_1"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR06136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="148" mass="16327" checksum="9D98CC1F64EC7B62" modified="2012-03-21" version="1">MSAEEEAPKPSKTYDGSCHCGNIKFSLTLSPPLEEGYKVLNCNCSICRRSGYLLIYPEKKDVTWHDGSRERCVNYRFNTKTKDQMFCGGCGSSLGIDFLEDTCYGISARALDGIDLDTLTYRKLDGVNKVSPAQDLSGTETKKASTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXP2</accession>
    <name>H1UXP2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_05072</name>
        <name evidence="8" type="ORF">CH63R_01114</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000523">
        <property type="protein sequence ID" value="CCF32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164451.1">
        <property type="nucleotide sequence ID" value="XM_018296089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXP2"/>
    <dbReference type="STRING" id="759273.H1UXP2"/>
    <dbReference type="GeneID" id="28860196"/>
    <dbReference type="KEGG" id="chig:CH63R_01114"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01114"/>
    <dbReference type="eggNOG" id="KOG2178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_7_2_1"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="660" mass="72133" checksum="A3E482D1873FEB88" modified="2012-03-21" version="1">MSGIVSSPTALHPALSNPNPLPPAPAPLQQAQQQPSYCSPSERVIKTGSLSDRPKSSNAAHDRPLSSSSTSVSTSALPALSLFRNAEAVAEVPYSCAPGGPPAAAPTSTYAPSSTIRRSSLSITSTAAYPELLPPPLSRSSNANNAAHHPPKGHRRAPSHEVPRQTIMKALASVVRGNKPEALSLTGMLSQQGGSVDNRPATSSSQKLADALNELASRNMTPTTALPSLQSPCFYHNRFDDAVNIDKVLEEIKNDDCMSHSRLVQTATGVREVSKQLQRRPIKRAVRNVMIVTKARDNQLVYLTRELATWLLRTPRYGSEVGVNVFVDAKLRNSRRFDAGAILAENPAFQDMLKYWTPDLCWTQPEKFDLVLTLGGDGTVLFTSWLFQRIVPPVLSFSLGSLGFLTSFEFERYKQHLDRIMGEEGMRVNLRMRFTCTVYRYGTLGQEAEEGEQFEVLNELVIDRGPSPYVSNLELYGDDELLTVVQADGCIFSTPTGSTAYSLSAGGSLVHPDIPAILLTPICPHTLSFRPMVLSDTMLLRVSVPRNSRATAYCAFDGKGRVELRQGDYVTITASQYPFPTVVRTQTEWFDSVSRTLRWNTRAATQKGFDPSADGSLCPSEDGKDEDPEWDIDTDSACYASEDGSISASPLRRQMSLLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZW5</accession>
    <name>H1UZW5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-l-methionine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00142</name>
        <name evidence="4" type="ORF">CH63R_10460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000791">
        <property type="protein sequence ID" value="CCF33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154858.1">
        <property type="nucleotide sequence ID" value="XM_018305434.1"/>
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    <dbReference type="STRING" id="759273.H1UZW5"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030612_2_0_1"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497542" evidence="2">
        <location>
            <begin position="26"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR06340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="455" mass="50721" checksum="F8AA861F98731E8C" modified="2012-03-21" version="1">MKLCNPTTWLALSLACGVLSTASEANVDNNGPLNKVAVADVHSEEETLASMPVDSFVEFHEVTVTIEEAPERPSPRHEQEKKNLLKRMSKSHGKWDTNHPRHRLLEALFGFSRYKPRQMAELDRYKGLYKHVSKAQKAVLEKTVKYSQKFETAEQLLDLNQQLCDEIVETALEFYGISHEELADHSKAKDNAGQAADRVSTSQALKHFVRDWSTAGTGERDDAFPCILDTLQTLFPDRSSRDIKILFPGAGVGRLGHEVAGLGGFEVTINEWSMFMNLAYRFLEAHPRPGTKALHPFVDSWSHHATTSDMFRGVSFPDRRVNASSVLLVEGDFTSAFKSDKGQYDVVVTHFFIDTARNIMSYLDSIHALLKPGGYWINFGPLLWGTGPFVQLSLDEIVAVSKSIGFEFVDGSEQCGGVTLQGEKVRGKEAVYGFNDKALTKNAYSAQSWVAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0M7</accession>
    <name>H1V0M7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">ATP-dependent metallopeptidase HflB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH063_05907</name>
        <name evidence="21" type="ORF">CH63R_04307</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000892">
        <property type="protein sequence ID" value="CCF33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160528.1">
        <property type="nucleotide sequence ID" value="XM_018299282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0M7"/>
    <dbReference type="STRING" id="759273.H1V0M7"/>
    <dbReference type="MEROPS" id="M41.003"/>
    <dbReference type="GeneID" id="28863389"/>
    <dbReference type="KEGG" id="chig:CH63R_04307"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04307"/>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_23_4_1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
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    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="443"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="854"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCF33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="902" mass="100882" checksum="512F385C150ABC8B" modified="2012-03-21" version="1">MARFLRQSAQLSRAVRLAQQPAVTRMRFQPSRIARLGQQAPLACYRSRFYSTNGPQPPNNEKDPNEKKPEKEEQQQQQDPAKPQLSKEEQIRKEWPLPEGWVYLTEEELGMMRTMAENGRLPQFQKEFFIKSVEEMKLLGVPNELRELLTSLKERKLKMTITDISKILRISTQVAKRFSDYEATVLMREEQDPNKQKQDGAKDSEQGNEQKDGRNGQENEGGPGGLGGKKWIFGVFGTGDLIVASLVWVVVYPFFESMIFGQEKEITWQELRRSFLDKGLVNKFVVIKNPGRVRVELNREGVQSVYGGNEGINPDVHYYFSIGSVEMFERQLEEAQRELGIPAAERIPVSYASEGGFMPLVYAFGPTLLLVGLLYYTTKQMGGRGGNQMFGFGKSKAKRFNHETAIKVKFSDVAGMDEAKTEIMEFVSFLKTPERFERLGAKIPRGAILAGPPGTGKTLLAKATAGESGVPFFSVSGSEFVEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGRSRQEGNRMGGNDEREATLNQILTEMDGFNTQEQVVVLAGTNRADILDKALMRPGRFDRHIFIDRPTMKGRQDIFKVHLGKVVTKEDMDHLTGRLATLTPGFSGADIANAVNEAALIAARASADSVEMIHFEQAIERVIGGLERKSLVLNPQEKKTVAYHEAGHAICGWFLKNADPLLKVSIIPRGQGALGYAQYLPQGDAYLMTVEQLMDRMAMTLGGRISEELHFPTVTTGASDDFRKVTHMARKMVTQWGMSEKVGPLHFDDDPNTLQKPFAEATAQAIDAEVHRIVEEAYKQCRDLLTEKKAEVGIVAEELLKKEMLTRDDLVRLLGPRPFGDNQEFEKYFGGQGQKSAPPPFPAEEIDNPPEQPPVPPAPAFKSLEDAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1I7</accession>
    <name>H1V1I7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">SNF2 super family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH063_06159</name>
        <name evidence="18" type="ORF">CH63R_02904</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001009">
        <property type="protein sequence ID" value="CCF34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162695.1">
        <property type="nucleotide sequence ID" value="XM_018297879.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1V1I7"/>
    <dbReference type="GeneID" id="28861986"/>
    <dbReference type="KEGG" id="chig:CH63R_02904"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02904"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140015">
        <property type="term" value="F:histone H3K14ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2E0</accession>
    <name>H1V2E0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor 3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00168</name>
        <name evidence="4" type="ORF">CH63R_12692</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001124">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="C:U2 snRNP"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="DUF382"/>
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    <dbReference type="InterPro" id="IPR052584">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
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        <property type="entry name" value="DUF382"/>
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    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
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            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="580"/>
            <end position="604"/>
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            <begin position="10"/>
            <end position="19"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="433"/>
            <end position="445"/>
        </location>
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            <begin position="581"/>
            <end position="597"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF34392.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR03565.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="604" mass="67800" checksum="3245D09FB33CCEAB" modified="2012-03-21" version="1">MAAPKMTKNQMRRAKKKELKKTQVETASKTPEPNDEKKPEEADTQEKAGEELEVKKDAETSVNGVADGPAEDDVDLDDERFAAFKDIFSKFGVSLDEDEVAKEANAGNQGEVIWDDDDIPSEDEEATGQTKLSKKKRKQLNKLSIAELKALVKIPDVVEWQDTSSSDPRLLVQIKAQRNVVPVPGHWQLKREYLSSKRGIEKPPFRLPKFIAETGITEMRDAVLEKQEQQSLKQKQRERVAPKMGKLDIDYQKLYDAFFRFQTKPELTRFGEVYYEGKESEVDFQHFRPGELTEATKEALGMPPGAPPPWLINQQRFGPPPSYPTMKIPGLNAPPPPGGSWGFHPGGWGKPPVDEFNRPLYGGDVFGLTNQAGAQVAPPVAQPLGTSEPVEKTLWGELQPRDEESEEEESEDESEDEEEEDADVPGGLATPSGIETSGGMVSSVPTDYPGQGVETSVAGEMDLRKQRRGFDTEESSHPRSAYQVIPERQQRTEGFFGSDRVYDLNQQKGAGNVPVLGQEDDSRKRKKPGDVDVALDPDALQSHDGISKDELRRRFEEGKREEGIGAKWAYEEDLSEMIAQESRKRQKVDEKRNDEKKKQSKYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1V2U2</accession>
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        <recommendedName>
            <fullName evidence="6">Protein CMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_06516</name>
        <name evidence="3" type="ORF">CH63R_09950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001181">
        <property type="protein sequence ID" value="CCF34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154348.1">
        <property type="nucleotide sequence ID" value="XM_018304924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2U2"/>
    <dbReference type="STRING" id="759273.H1V2U2"/>
    <dbReference type="GeneID" id="28869031"/>
    <dbReference type="KEGG" id="chig:CH63R_09950"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09950"/>
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    <dbReference type="HOGENOM" id="CLU_057568_0_1_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cms1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24030:SF0">
        <property type="entry name" value="PROTEIN CMSS1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27792" checksum="B4041BD3FFDE252D" modified="2012-03-21" version="1">MSNSKKRAAPSQDGEGQVKKQKKKSAYHVDETLLNAELGINEAFAVMDNQLLADYTAQKIARFGTDLSPVEVSDLSISANAIKDATSWTEPRALEKLPEFLEKFAEKPERLGTAPEKKGAPHTIIVAGAGLRAADIVRAVRKFQSKKSTVSKLFAKHMKVEEQVKFLQNTRTGIAVGTPARLMELADNGALSLEKLQRIVVDASHIDQKKRGIMDMKDTMLPLARWLTRQEFRERYVDDKKHLDLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="13">Pre-mRNA-splicing factor CLF1</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="ORF">CH63R_11842</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001458">
        <property type="protein sequence ID" value="CCF35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153657.1">
        <property type="nucleotide sequence ID" value="XM_018306816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V4U1"/>
    <dbReference type="STRING" id="759273.H1V4U1"/>
    <dbReference type="GeneID" id="28870923"/>
    <dbReference type="KEGG" id="chig:CH63R_11842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11842"/>
    <dbReference type="eggNOG" id="KOG1915">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011554_1_0_1"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="377"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="672" mass="80507" checksum="5A8BC466C4CF8819" modified="2012-03-21" version="1">MEASRGPPKVKNKAAAPVQISAEQLLREAVDRQEVALQAPTQRFADLEELHEFQGRKRREFEDYVRRNRVNLNNWMRYAQWELEQKEFARARSVFERALDVHPNEIRLWIRYIESEMKCRNINHARNLLDRAVARLPRVDKLWYKYVYMEEMLGNVPGTRQVFDRWMQWQPDEAAWSAYIKLEKRYGEYDRARDIFRAFTLVHPEPRNWIKWARFEEEYGTSDMVRDVFGTAIGELGDEFVDEKLFIAYARYEAKLKEYERARAIYKYALDRLPRSKSMALHKAYTMFEKQFGDKDGVEDVVLSKRRVFYEAQVKENPKNYDTWFDYTRLEETSGDLDRVRDVYERAVAQVPPAQEKRFWRRYIYLWINYAIFEELQAKDAERARQIYRVCLELIPHKKFTFAKIWLLKAQFELRQGELTAARKTLGQAIGMCPKDKLFRGYIELELKLFEFLRCRTLYEKHIEWNPSNCQTWIKFAELERGLDDLERTRAIFELAVSQPVLDMPELLWKAYIDFEEEEGEYERTRELYERLLEKTDHVKVWISFAHFELNIPEDEEEAEEEAPISNEAKARARKVFERAHKSMREKDLKEEAVTLLNAWLSFERTHGVDDDVAKVQKLMPRKTKRRRRLDDDSFEEYIDYVFPADDKQTQNLSNLLAMAQAWKQQGGDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V698</accession>
    <name>H1V698_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_01370</name>
        <name evidence="10" type="ORF">CH63R_04593</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
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    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG2001">
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    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="550"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="863"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="93"/>
            <end position="107"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="121"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU363050"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF17681"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6K1</accession>
    <name>H1V6K1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_01382</name>
        <name evidence="8" type="ORF">CH63R_00066</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001724">
        <property type="protein sequence ID" value="CCF35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163403.1">
        <property type="nucleotide sequence ID" value="XM_018295041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V6K1"/>
    <dbReference type="STRING" id="759273.H1V6K1"/>
    <dbReference type="GeneID" id="28859148"/>
    <dbReference type="KEGG" id="chig:CH63R_00066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00066"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_3_1"/>
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        <property type="entry name" value="STAS_dom_sf"/>
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        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SULFATE TRANSPORTER"/>
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        <property type="entry name" value="SpoIIaa-like"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="109"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        <source>
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        <source>
            <dbReference type="EMBL" id="OBR14886.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="685" mass="74816" checksum="14E6000B3CCA79BF" modified="2012-03-21" version="1">MDKINRKIEKLRDEVTTDATLAQVRDFVVSGAPKLPSAAGVYLLEKVPIVQWLPRYSPKWLITDFIAGLTVGVMLIPQSLAYAKIATIPIANGLYSSWLPAAFAVIMGTSKDLSTGPTSILGLLTAEIVHDLSEEGFDISAIASSVALMVGVYSLVIGLFGLGFILDYVSFPVLTGFISAAALVIAFGQVGSLVGLSNVPSGVFNVIGNVLRRLPDWDGPTCGIGLGTLVILIALEKVGKKWGKRHYAIKLLANSRAVIVLVVFTLISYLVNRGRDKSDYSWKVSQVNTHGITQPIVPAANLVQKVAVRAVAPLVASTLEHLAVGKAFGRKNNYQIDQSQEFNYLGVVNIVNSFFSTMPVGGAMSRTAVASECGVKSPLTGLFTAAFILLTLYVLSPALYWLPSATLSAIIIMAVVHLFGPLSLFYRFWRISFPDFVASMVSFWVTIFVSAEIGIGVAAGWSIVWTMLRSTFVKPAIHSSNNGVVHTIPQPITRIISDGGRRVTENRTENASIAIPGDTIVVDFNDAIFFPNAERAKTATLTAIKLVYPRVETSMGQDDRERHWSVAAEKRLERIRAQRQIRLKETPLAVVVWDFTMVPYIDTSGIMTLKELKTEIQSHSGKSVQIRMVGMSDKVRSRFLRAKWSLVDLEEWREEDADLVYPSMETAIWDRDGDSGADGSSEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7A1</accession>
    <name>H1V7A1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate assimilation regulatory protein nira-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_01432</name>
        <name evidence="9" type="ORF">CH63R_03577</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001835">
        <property type="protein sequence ID" value="CCF36103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159798.1">
        <property type="nucleotide sequence ID" value="XM_018298552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7A1"/>
    <dbReference type="STRING" id="759273.H1V7A1"/>
    <dbReference type="GeneID" id="28862659"/>
    <dbReference type="KEGG" id="chig:CH63R_03577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03577"/>
    <dbReference type="eggNOG" id="ENOG502SK8P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011581_2_0_1"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF36103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="810" mass="89157" checksum="B5A0993411705125" modified="2012-03-21" version="1">MADLYGSSNGNNNNINNSSNSRNGNNNNDNLGRHLRPERPPTAAAAAVTTTTTTITSNPSTTTDLAAAAAATTVTASSASGAAAPAASSSVSPKPTKRSSATTCVTCRARKVRCDGRRDVCSNCERLGFSCTYEDPTSEANGLAAAPAFPLPRRRVRQACQSCHSRKARCSGHTPACDRCRAQGIECVYRVSKRTRLSINPPASRSDHAVRSPTSSTSAAATSRDHQTRRSLSRDDAAHDSDAVGADAVASNTPSTFNRDLSAPDPQFESLISRALDNFFRHVHHIPMLSFLHRASLMQRHHVGGLDRPLLLALIGITSLLTDLGPGTSDYGEKCVDESESLILKSLENASTIKVQTLALIIKYRILTRRFSSAFMLAATAARFATALRLNYENPDLCFLAQESRRRLMWALFMIDQGMAGGYRDLTLWTPETIHISLPCNERDFEFDLAPPSLRPLVPGPDESENDDIGSLALHVRILWLRGRILKFAKRASNCSHDDLDRLKEQLQSFAEELSDFAERLPVSFRWSDNSLRLRAYSPRLCVFIMIHVWWRQCNCDLFRIGLVGLRDSVSRSAAERLGPEFIAGCQRQCFQHAMEMSNMFTSIKQLDHYPVADLDMPVCAYQCIRMLYYIYHLNAEEYGLTPDILRKKATVCLDVTKGCCSGTAAVSIQADLQRLMDHGLSIQATPSRLLSEEPQDERNGNGAKRIRLSRAKQVQLVEDPDSGAPAADELTNRPFGIGAWEDIQVPEAEKPVEQVPAPPQQPTALGSLEVNNAFEGALDSLDFNMEPMGLDSLAWFSNEWAQGDFQGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1V853</accession>
    <name>H1V853_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_07987</name>
        <name evidence="8" type="ORF">CH63R_01276</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001964">
        <property type="protein sequence ID" value="CCF36405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164613.1">
        <property type="nucleotide sequence ID" value="XM_018296251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V853"/>
    <dbReference type="STRING" id="759273.H1V853"/>
    <dbReference type="GeneID" id="28860358"/>
    <dbReference type="KEGG" id="chig:CH63R_01276"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01276"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021753_0_0_1"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF36405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="900" mass="99618" checksum="EF7537C06E05F316" modified="2012-03-21" version="1">MLRHGSILGFFLKPLGWIPGGPQQAAYAAALGLVAIQVGIGIIMKISQTGGSYSFSPSASVTISEFFKMVLSTIFFYNECKRRVADGIRPSTRGGGTGYSSLATSELPMNERSSLDEKREEEGLSGSASSSSNSNAVEKHTGPLQPLDLRTYWSYIRGEVTRDVRYGFCNLALFYVLINNSIFVSYKMADPGTIQLTKSGVTFITALVMIATLNTKISKIQWIAILMQICGLSVTQYNPQTGTTYPFSTYFILLFQVFLSASSGVYNQALLKTDDSSLHADNMILYGAGATMNLLCHLVIKALKADEPGFFEGYNSFGAIMVIVSNVFIGLAITAVYKYADAVIKCFATAVATGILLYVSPLLFGTNLSFLVLPGTVVVFVASWLYMDNPPPKDPNPPTANEPQKMSLFNKMAAVAKKFNKIFLAVATFITVLIVAFLTMSEAKMPDFAKDGGSASPAPAGPKPVTGTESKVESPFKNTMAMIRWNSARPERIPMLQKYEPFFHTVHISMPNMFQGEDPEFHNLTHDQFPGTFTVYKQVARTMKLILDTAPEIDGLMYYHFDAWIDPLAWTGMNPYNIHFPSVIDTAPPSHGGPEYMCLTDIKFYNWWGWGQDFHRTSMAASAVVDNFDLDYKIRRDEWCVGWSDIYYIPRRFFADYIFLSEIFAGFGVFHEVAIPTIVHIIDQSRRRNPYRSIIDRLSDCWGNCCTSDPKIRDVLGARCGHRLNYLDEGPTNAFYDKLDAQASVLGQPLNSTKYAMTSNEAAHLFDSAVLASINNGEAKKVAPANDDALEDDQRADKLAAEKAKQEKEMLKNEHAPVDKTEKPGDPKADPAKITPPPPPSDDKTAKPKDAKESDKKEEDKKEGDKKVDPNDALREADRDADVKRRLRREVVAAVAGLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8E6</accession>
    <name>H1V8E6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_08060</name>
        <name evidence="10" type="ORF">CH63R_00004</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002010">
        <property type="protein sequence ID" value="CCF36499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163341.1">
        <property type="nucleotide sequence ID" value="XM_018294979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8E6"/>
    <dbReference type="STRING" id="759273.H1V8E6"/>
    <dbReference type="GeneID" id="28859086"/>
    <dbReference type="KEGG" id="chig:CH63R_00004"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00004"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF36499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="56719" checksum="771F67770C929410" modified="2012-03-21" version="1">MALGTDEPLAFVSAIPDSTVDTKYWWRSKNLRALNLLLVFPMLSIFTQGFDGSMMNGLQSVENWRNYFGEPKGATLGLFNAAYPIGGLCAIPFISIISDTFGRRAGLACGASLCILGATLQAAAQSLPMFVVARGILGCGTVFLGSSGAPLITEIAHPAHRATATALFNTSYSLGAIVAAWTTFGTFRIESTASWRIPSGLQGLPSIIQLLGLYFVPESPRWLASKDRNEEALAFLAKYHAEGNEHDALVQFEYDEIRSALAYERTVDRGSWLQNYLELVRTPGNRKRMFILLWTSCIAQMSGNAFISYYLSPVLTSVGLTSSLEQTLINATQQVLSWISAMYFATLPEKLGRKMLFLGSLTAIFVCLVSITAGSAVFAKNGSNKAAGGAVVAFLYLFSPSYNLGLNGNLVLYITEILPYSLRMRGQACFQFFSTCFTLISTYAVPVGLESMAWKFYIIFIPWVVVEFAVLYFVYPETKGPSLEEIAIIFDGVSTSRTGSSGKDGILHVELEKSDPADQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8R6</accession>
    <name>H1V8R6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_08149</name>
        <name evidence="19" type="ORF">CH63R_13528</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002065">
        <property type="protein sequence ID" value="CCF36619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150820.1">
        <property type="nucleotide sequence ID" value="XM_018308502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8R6"/>
    <dbReference type="STRING" id="759273.H1V8R6"/>
    <dbReference type="GeneID" id="28872609"/>
    <dbReference type="KEGG" id="chig:CH63R_13528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13528"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="COPB2"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR19876">
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        <property type="entry name" value="GPROTEINBRPT"/>
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    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
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            <begin position="195"/>
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        </location>
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    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
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            <begin position="318"/>
            <end position="577"/>
        </location>
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        <location>
            <begin position="810"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
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            <dbReference type="EMBL" id="CCF36619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="863" mass="96253" checksum="6D7A554412829042" modified="2012-03-21" version="1">MKVDVKRQLFARSERVKGIDFHPQEPWILTTLYSGHVYIWSYETQQIVKTFELTDVPVRAGRFVARKNWIVCGSDDFQIRVYNYNTSEKITSFEAHPDYIRAIAIHPTQPFVLTASDDMTIKLWDWEKGWKCVQVFEGHGHYVMGLAINPKDTNTFASASLDRTVKIWSLGSATPNFTLEAHEAKGVNHVDYYPHSDKPYLLTTSDDRTVKVWDYTTKSLIATLEGHTNNVSFACYHPELPVIISGSEDGTIRLWHANTYRFEQSLNYGLERAWCVSYQKGKQGVAVGFDDGAVVVKLGREEPAVSMDASGKLVWARHNEVVSAIIKGGDDTIKDNEPISLPVKELGTCEVYPSTLVHNPNGRFVAVCGDGEYIIYTALAWRNKAFGSALDFVWASKENTNDFAIRESATSVKVYKNFVEKPGGLDVGFQAEGLTGGVLLGVKGQGGISFFDWQTGGLVRRIEVEPREVYWSDSGELVALACEDTFYVLRFSRDAYVEGVQSGQIDEDGVESAFEVITDINESVRTGEWVGDCFLYTNSTNRLNYLVGDQTYTVSHFDQSMYILGYIQRDSRIYLADKDVGVTSFALSLPVLEYQTLVLRDEMETAQELLPTIPADQLNKIARFLEGQGHKELALEVATDPEHKFDLALGLGQLDTALDLAREADVEHKWKTVGDAALAGWQVTVAQECFTHAKDLGSLLLLYSSTSDRSGLSKLAEQAQEAGAHNVAFSCKWLLGDVAGCVEILTKTGRLAEAVLFSQTYKPSVTADVVKEWKESLEKSKKGRVSKMIGVPVEDEELFPEWDEWLQLEKQGGAAPEVAEIKEVNGAESPEAAEEAEEADEAEEDDVEEESDDKEVETEEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VA20</accession>
    <name>H1VA20_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_01626</name>
        <name evidence="11" type="ORF">CH63R_13139</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002290">
        <property type="protein sequence ID" value="CCF37073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152530.1">
        <property type="nucleotide sequence ID" value="XM_018308113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA20"/>
    <dbReference type="STRING" id="759273.H1VA20"/>
    <dbReference type="GeneID" id="28872220"/>
    <dbReference type="KEGG" id="chig:CH63R_13139"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13139"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS lactose permease, putative"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
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    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF37073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR04012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="545" mass="59947" checksum="34DA6CF730BB5729" modified="2012-03-21" version="1">MADPTKQASTLADEKRDLYNNHVTEDAPPDVVAAVAAHEIAHEVEDGNYSPWTKSMWHLYGVLFVAYCCGALNGYDGSLMGSLNGMKSYQRTFNMKTSGSSTGIVFMMYNVGSVCAIGFTGPVNDLLGRRWGMFTGAVLIIVGTCVQATSNIVPQFLGGRFLLGFGVSFCCVSAPTYVSELAHPKWRGTLTGLYNCMWPVGAFIAGFVAYGSSFIPGDGGWRVPVWCQLATSGIVLIFVFFLPESPRWLVANDRHEEAAKILTALHGEKDPDHPIVQLQMKEMLAQISSEASDKRWWDYRELWNTHSARRRLICVLGMAIMGQASGNSLSSYYLVTMMNTAGIEEEKKVLALNAVNSILGLFGSLIGARLTDRIGRRPLLIYSILFCSATFAVMTGTSKMAVDDKTNTNAANATIAFVFLFGVIFSLGWTAQQSMYIAETLSTSTRAKGTAVGNFASSAISLVLAYSSGPAFEKIGYYFYLVFVFWDILEAVFIYFYFPETNHRTLEELEEVFSAPNPVKKSLEPRNASTVLDTMKIHNEKFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAP9</accession>
    <name>H1VAP9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08667</name>
        <name evidence="3" type="ORF">CH63R_10999</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002402">
        <property type="protein sequence ID" value="CCF37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155397.1">
        <property type="nucleotide sequence ID" value="XM_018305973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAP9"/>
    <dbReference type="STRING" id="759273.H1VAP9"/>
    <dbReference type="GeneID" id="28870080"/>
    <dbReference type="KEGG" id="chig:CH63R_10999"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10999"/>
    <dbReference type="eggNOG" id="ENOG502RASH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037039_1_0_1"/>
    <dbReference type="OrthoDB" id="5236816at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="479" mass="52899" checksum="D411F4C1A9F6E7E1" modified="2012-03-21" version="1">MDLPSSAPTAPTASPMSSPESIHATPPTSSPAPAIPSPTKRMRRRRIYRPDEGSLYDLLYEHAGLSLFVRPICWTDLHIRLLNARFIELPPCDTPVPPPSPRGAPVSPSKCHMKPSAAATTLSRELTAMLAPGSTRSFYTNSIRTIMSTLYPGKLSRARTQFDMHLYFGGLVYRETCRVQVAWDAMPSRSGSIASFESASTRPAESFNIVPSGANVSASNGSSQQSTYTQPVLAYIGKLQIAATRKNMYRVIPGPNRAYNGPVERLQQLRSKTFVPANPNHDPLLVGIMLAMAQRRFYGEPLPSANKWIPSRPMPTGLGEPVFHDVTVELLTNDNETSDFIVYKGTVTAELLRKFHEPTKNLGTIARETAADKVERLACDGGMRIEYTRVPVWPILGLKERLGKALGKEVVGHFDEDNIETWEEEAERNSDKLKRRRDREALAEVLNGSFEEEAPDGMPLSGKRRCLVDEESGQVGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBV8</accession>
    <name>H1VBV8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ALB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08973</name>
        <name evidence="3" type="ORF">CH63R_13422</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002593">
        <property type="protein sequence ID" value="CCF37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152813.1">
        <property type="nucleotide sequence ID" value="XM_018308396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBV8"/>
    <dbReference type="STRING" id="759273.H1VBV8"/>
    <dbReference type="GeneID" id="28872503"/>
    <dbReference type="KEGG" id="chig:CH63R_13422"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13422"/>
    <dbReference type="eggNOG" id="ENOG502RJPK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148217_0_0_1"/>
    <dbReference type="OrthoDB" id="5422107at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12039" checksum="5BCF56E14B7392B0" modified="2012-03-21" version="1">MPSVKNPNGPSKNRLANRALGAKMQRRKKSEANRNKILKTDAMRGAKPGLAPTSGPNAPLSKKKAKKVEKRIAHALRRKMAAEGEVVMKDVEPMEEDKPEEAAAEAENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCA7</accession>
    <name>H1VCA7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ornithine decarboxylase</fullName>
            <ecNumber evidence="11">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH063_09100</name>
        <name evidence="20" type="ORF">CH63R_04060</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="11"/>
    <dbReference type="EMBL" id="CACQ02002674">
        <property type="protein sequence ID" value="CCF37860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160281.1">
        <property type="nucleotide sequence ID" value="XM_018299035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCA7"/>
    <dbReference type="STRING" id="759273.H1VCA7"/>
    <dbReference type="GeneID" id="28863142"/>
    <dbReference type="KEGG" id="chig:CH63R_04060"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04060"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_2_1"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0702">S-nitrosylation</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="79"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="17">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCF37860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR11764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="455" mass="50415" checksum="A45F2CC5A1466B3D" modified="2012-03-21" version="1">MVMATAAIEHFAPATINYASTYQPVLKTSHFVDHAHHHSKHGVTNPKQLIGDALRQRVESIDHEICEPGDEDTFFVGDLGEVYRQHMRWKLNLPRVKPFYAVKCNPDPKVLQLLAALGTGFDCASKTEIDQVLNMGTAPERIIYAQPCKTNSYVRYVKAMGVKQMTFDNADELRKIAKLFPEAELYLRIMTDDESSLCRLSMKFGAAKEATNDLLGVAKDLGLNVVGVSFHVGSGASDPMAFYKAVYDAYEVFEQGRAYGFEMKTLDIGGGFCGDTFEDMAAVLRGALDEYFPASSNVNIIAEPGRYYVSAAFTIACNIIARRTVDDPTLNEKRYMVYVNDGLYGNFSSIMFDHQHPVAKVLRAGSSTVYDTSAANACPDGEGIRYSVWGPTCDGIDRITETISFEQELDVGDWLYFEDMGAYTKCSATKFNGFSNEHDVIYVCSEPGAKALLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDI5</accession>
    <name>H1VDI5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_01882</name>
        <name evidence="5" type="ORF">CH63R_07500</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002901">
        <property type="protein sequence ID" value="CCF38288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157253.1">
        <property type="nucleotide sequence ID" value="XM_018302475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDI5"/>
    <dbReference type="STRING" id="759273.H1VDI5"/>
    <dbReference type="GeneID" id="28866582"/>
    <dbReference type="KEGG" id="chig:CH63R_07500"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07500"/>
    <dbReference type="eggNOG" id="KOG3859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021805_1_0_1"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="152"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF38288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="513" mass="57787" checksum="F65B7C7B1C9D0E57" modified="2012-03-21" version="1">MSQARRSSFGMLLRRSKSGDLGKGGKKAQAQREQQEREVERQRQAAVSKNPPKLPEFYKVNDQLSNSIPSDLRAEEASIMSDHTIGTAYSTRPSMEPGRSGVGFVPPIPPIPANAYDPYARTESMTHRGRYSYASSAISTVNSPRRVRRRKDPTPFNILVIGTRGAGKTSFLEFLKTALALPPKKRSRRTEAEEDSSPRPPPSGNFIPHYLETEIDSERVGLTIWDSEGLEKNVVDLQLREMSAFLESKFEETFTEEMKVIRSPGVQDTHIHAVFMVLDPARLDRNLASVRSGVSNGHNGKYAPPARIQGGLDEDLDLQVLRTLQGKTTVIPVISKSDTITTKHMNVLKKTVWETIKKSGLDPLEALGVDEDDDSTKIEEEDEIASENEQAVSHDEDDFPFQDRERAPSSPGSKRLSSSSIRQHKANQGAKAEEIPFLPLSVISPDLYEPEVLGRQFPWGFADPYNKEHCDFTRLKDAVFSEWRAELREASREQWYEGWRTSRLKNNPNARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEF2</accession>
    <name>H1VEF2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galactosyl transferase GMA12/MNN10 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_01943</name>
        <name evidence="7" type="ORF">CH63R_00513</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003057">
        <property type="protein sequence ID" value="CCF38605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018295488.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VEF2"/>
    <dbReference type="STRING" id="759273.H1VEF2"/>
    <dbReference type="GeneID" id="28859595"/>
    <dbReference type="KEGG" id="chig:CH63R_00513"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00513"/>
    <dbReference type="eggNOG" id="KOG4748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021434_0_0_1"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000117">
        <property type="entry name" value="Glycosyltransferase family 34 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF38605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR15333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="456" mass="53404" checksum="1673CF543DC69A47" modified="2012-03-21" version="1">MSLSRSPSPIPGGGWASPGLTINTSGRSSPSRGFSASNGASTPWETAKMRTAGMNGYPSFSTQNQGFFTRHMRRISSSLPRFNNQSPYADKEKPGRASWATRKVPLVGRIRSVFARMGRKMKLRLLILLLFSLAMVIFYNTPLVYHWRRHFGGGQKYVIILAANVGGGVMEWKGAREWAIERDSVRNKKKYANRWGYDLEIVDMSTKKRYAHEWRESWEKVDFIRSAFRKYPKAEWVWWLDLNTYVMELSYPLQNHIFNDLNKHVYRDINEFNPLNITHPFTDPYLDEESRSAIGDGKPESINLMLSQDCSGFNLGSFFVKRGNWADRMLDIWWDPVAYEQKHMEWEHKEQDALEQLYTTQPWIRKHTAFLPQRMINSFPPGACSENGNDTRIHYDQKDRDFVVNMAGCEWGRDCWGEMYNYRELSYYLNRNPWERFKEDLIAVLWFKLTGQKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VF24</accession>
    <name>H1VF24_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09821</name>
        <name evidence="3" type="ORF">CH63R_09806</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003176">
        <property type="protein sequence ID" value="CCF38827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154204.1">
        <property type="nucleotide sequence ID" value="XM_018304780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VF24"/>
    <dbReference type="STRING" id="759273.H1VF24"/>
    <dbReference type="GeneID" id="28868887"/>
    <dbReference type="KEGG" id="chig:CH63R_09806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09806"/>
    <dbReference type="eggNOG" id="ENOG502RU96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118689_1_0_1"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="168" mass="18317" checksum="65AAC422A462A026" modified="2012-03-21" version="1">MPQPATAPWGLAITDSDFRKLKAGLQVYSMDDRWHVSFTEQRKSDTVTIHIVRHGSYELYSIVIKPGDGCAVIETINWAQDQGGNRITEGIAKMHVVMLTRRNMECEFEGLPDCDSEDFFDEPAPGSYDTPNFLSNGTNTNGTNGTNGTSGTNSINGTNGTNGTNGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFX7</accession>
    <name>H1VFX7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_10044</name>
        <name evidence="2" type="ORF">CH63R_08463</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003329">
        <property type="protein sequence ID" value="CCF39130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155460.1">
        <property type="nucleotide sequence ID" value="XM_018303437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFX7"/>
    <dbReference type="GeneID" id="28867544"/>
    <dbReference type="KEGG" id="chig:CH63R_08463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08463"/>
    <dbReference type="HOGENOM" id="CLU_2320225_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF39130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="99" mass="11378" checksum="843544656628624B" modified="2012-03-21" version="1">MVVSRRRFLGQFELQIRSAGLSDNADLTRPVNSPSSLMMELGLVLVRKMKAPWELPLLRYKGRLLFTSVDAKINENRSCIREQKKHKSSSVEKDLIYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGY0</accession>
    <name>H1VGY0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_02140</name>
        <name evidence="7" type="ORF">CH63R_08088</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02003523">
        <property type="protein sequence ID" value="CCF39483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157840.1">
        <property type="nucleotide sequence ID" value="XM_018303062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGY0"/>
    <dbReference type="STRING" id="759273.H1VGY0"/>
    <dbReference type="GeneID" id="28867169"/>
    <dbReference type="KEGG" id="chig:CH63R_08088"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08088"/>
    <dbReference type="eggNOG" id="KOG3985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_1"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
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        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
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        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF39483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="33516" checksum="5AC63C3C1A0F24EE" modified="2012-03-21" version="1">MASLPETFDRPVHIAVIGGTGLGKLEGYTPVAALNPTTPWGKPSSPIQILEHNGVPIAFLARHGLHHQFAPHEVPARANIAALRSIGVRCVIAFSAVGSLREEIKPMDFVVPDQVIDRTKGVRPFTFFEGGVVGHVGFADPFDKGLAEVVKRCAAHMQGDGVVLHEKGTIICMEGPQFSTRAESHMYRSWGGSVINMSALPEAKLAREAEMAYQMICMATDYDCWHSFEDVDVAMVMKYMAANSENAKRLVGGVLDELSKQDNSDMVLAKQWEGSSQGAVKFMTKPEGRNPEAMKRVEFLFPGFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VHV6</accession>
    <name>H1VHV6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10540</name>
        <name evidence="3" type="ORF">CH63R_10910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003709">
        <property type="protein sequence ID" value="CCF39809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155308.1">
        <property type="nucleotide sequence ID" value="XM_018305884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHV6"/>
    <dbReference type="GeneID" id="28869991"/>
    <dbReference type="KEGG" id="chig:CH63R_10910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10910"/>
    <dbReference type="eggNOG" id="ENOG502TED9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087072_0_0_1"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="266" mass="27922" checksum="86D80215864565C0" modified="2012-03-21" version="1">MDDQDIAAEIDPEMAAFMGFASFGTQPAAKKRKYNHRTDAVSDADTDAGHAPTRTSATGANQTALAARTPRAVSTENPAAPPPANTDEIALDDDDDVAVVDADRPSAAEDQDLEDGGARIYSDPSIAPALAHAQSLIDELSTRAGDGDAAAPSEESATPAPITLPSSSSAALPRRPDASWGKEMGSVPTTMPTRERPAQAQAADHQPRGGGGGGGHYQQHQGKDGKPWWEGYYDRASNENPWDRLEKKAGVQSRGSWVPRGQAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIT6</accession>
    <name>H1VIT6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CH063_02284</name>
        <name evidence="22" type="ORF">CH63R_03119</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003901">
        <property type="protein sequence ID" value="CCF40139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162910.1">
        <property type="nucleotide sequence ID" value="XM_018298094.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VIT6"/>
    <dbReference type="STRING" id="759273.H1VIT6"/>
    <dbReference type="GeneID" id="28862201"/>
    <dbReference type="KEGG" id="chig:CH63R_03119"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03119"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_040729_6_1_1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:endoplasmic reticulum exit site"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial fission"/>
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        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
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        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
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        <property type="entry name" value="Small_GTPase_SAR1"/>
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    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="76"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <position position="132"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="135"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="18">
        <location>
            <position position="176"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCF40139.1"/>
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        <source>
            <dbReference type="EMBL" id="OBR14393.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="192" mass="21406" checksum="2268670C3BFE46F7" modified="2012-03-21" version="1">MPPTSAYNTIDASSPPDITFDAPQQACSGMAIWYQGTVADGLQQNDRVAILQPTLHPTSEELAIGNVRFTTFDLGGHQQARRLWKDYFPEVNGIVFLVDAKDHERFAESKAELDALLSMEELAKVPFVILGNKIDHPDAISEEELRHQLGMYQTTGKGKVPLEGIRPIEVFMCSVVLRQGYGDGIRWLSQYV</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ78</accession>
    <name>H1VJ78_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_10892</name>
        <name evidence="10" type="ORF">CH63R_04926</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003983">
        <property type="protein sequence ID" value="CCF40281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161147.1">
        <property type="nucleotide sequence ID" value="XM_018299901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJ78"/>
    <dbReference type="GeneID" id="28864008"/>
    <dbReference type="KEGG" id="chig:CH63R_04926"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04926"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_3_1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF40281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="517" mass="59131" checksum="FCB634059A44FCC5" modified="2012-03-21" version="1">MGGERRIKSVAIIGAGAAGAVTAAAFKAENYFERIQVFERRESAGGTWIYDPNPAELPPLQPGSLPPDVDPAVEIPGELPQVKPHSQRERYTQTPIYRSLTTNVPDIAMSFSDSRFAYGPFAPHWVPRQYIENYFSLHKTDSILVLNTTVEDVTRIPAKDRPEQWRLTLRKFDAARNVDIWWQEVFDAVVLANGHYSVPYVPHVKGLDEYIKKFPGRVVHSKTYRTPEPFTGKKIVTIGNSASGHDVTEELVKTARTPVFQSRRSKSRWDADEPPPGIEWKPVIKEYHLDGRIVFEDGSHLDDVDHVIYCTGYKPSYPFWNSEANGGRALYDYKEGKLIKTFWHTFFQDFQTLGIVGMPRVLTFRSFEYQAIALARVFSGRHSVALPPVEEQERWERERAELVRKDGRKFHDIAWETGETFEWLNWLFRVAGLPTLRGKGRTPPVLSEELIWAVEHVRKYAEPGNPIDGDESKEKKKKEAEVAGTGFYGDGHEHRAEEQKGKWLLVQRPKKDLLGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL01</accession>
    <name>H1VL01_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="16">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH063_11346</name>
        <name evidence="20" type="ORF">CH63R_05975</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="16"/>
    <dbReference type="EMBL" id="CACQ02004374">
        <property type="protein sequence ID" value="CCF40904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158800.1">
        <property type="nucleotide sequence ID" value="XM_018300950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL01"/>
    <dbReference type="STRING" id="759273.H1VL01"/>
    <dbReference type="GeneID" id="28865057"/>
    <dbReference type="KEGG" id="chig:CH63R_05975"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05975"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
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        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
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    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
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    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
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    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
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    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
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    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
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        <property type="entry name" value="CYTB5RDTASE"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 15 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 16" id="KW-0520">NAD</keyword>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="90"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="145"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57692"/>
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        <location>
            <position position="163"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
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    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00047682"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU361226"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF40904.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR10283.1"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="341" mass="37164" checksum="CBC63E2ACB972AE7" modified="2012-03-21" version="1">MFARSAFRAAQPLKLPSCPPHQQARRYATEPAKGGSSNPALYAGAAAAVAGGAYYFLSGSSAPAAAQKAEAKIKDAVGAAPKKALTGGDQGFVSLKLEDVEIVNHNTKKFRFKLPEDDMVSGLTVASAVLTKYKGPEDEKATLRPYTPTSDEDAKGYVELLVKKYPNGPMSTHMHDMTPGQRLDFKGPLPKYPWSPNKHDHIALVAGGTGITPMYQLARAIFNNPDDKTKVTLVFGNVTEEDILLKKEFSELENTYPQRFRAFYVLDKPPKEWVGNKGYITKDLLKQVLPEPKSENIKVFVCGPPGLMNAVSGNKKSPKDQGELVGALKELGYSPDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VML1</accession>
    <name>H1VML1_COLHI</name>
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        <submittedName>
            <fullName evidence="4">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02598</name>
        <name evidence="5" type="ORF">CH63R_04741</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004713">
        <property type="protein sequence ID" value="CCF41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160962.1">
        <property type="nucleotide sequence ID" value="XM_018299716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VML1"/>
    <dbReference type="STRING" id="759273.H1VML1"/>
    <dbReference type="GeneID" id="28863823"/>
    <dbReference type="KEGG" id="chig:CH63R_04741"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04741"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_7_0_1"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="3">
        <location>
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            <end position="458"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="459" mass="51694" checksum="D1612FC0B2014362" modified="2012-03-21" version="1">MEVNLSTSALSEPVRLGFGFYFLPFATFLCFLVPVLYLFPPIPATTRDALLATHSQIGAASPRSKSRDQPPAGEQQKTETGTSAGGFAKVESLCVYPVKSCRGIEVARSKLLPTGLEFDRLYTFAQLKSPFPVSVDGAAEDGRDTHSWEFVTQRQFPLLATVKVDVYVPDATKKTVFLEKSGDAWIVLRFPWREPGWKGTMQWVAAKIRDGWRGEPEMEVLLPVEFPTDKEIEERGYTREDVRVWKEMVPALNMEKEIPGELSRYLGVSNKLALFRVDPGKLREVYRCAPAKEDAGYQPVVGFQDAYPLHLMNTGSLQDFDAKVPKDDELRHLDVRRFRANVIVSGAPAYDEESWMSVKFTQGTSKVTAPTKCQVSCRTVRCKMPNVDPVTGARHRVEPDRSLRKLRDVDEGAPRMGCLGMQMVPLFEGTDRVEYMQAWLEVGMSVEVLERGQHVYIKQ</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>H1VS68</accession>
    <name>H1VS68_COLHI</name>
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        <name evidence="2" type="ORF">CH63R_12347</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Glomerellaceae</taxon>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018307321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VS68"/>
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    <dbReference type="KEGG" id="chig:CH63R_12347"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12347"/>
    <dbReference type="HOGENOM" id="CLU_2386029_0_0_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCF43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="94" mass="10521" checksum="78D763247AC7D78C" modified="2012-03-21" version="1">MRMGQNRRQASKKGTKILGSLYIHRIDTRNVSSLGFHLTHPRRCLTCSSAIGAASRGLWPTPKLRVSPFQVAWAWFGLDRSGLQCPNTDTIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSY4</accession>
    <name>H1VSY4_COLHI</name>
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        <submittedName>
            <fullName evidence="3">Telomerase activating protein Est1</fullName>
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    <gene>
        <name evidence="2" type="ORF">CH063_13071</name>
        <name evidence="3" type="ORF">CH63R_02355</name>
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    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006029">
        <property type="protein sequence ID" value="CCF43342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162146.1">
        <property type="nucleotide sequence ID" value="XM_018297330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSY4"/>
    <dbReference type="STRING" id="759273.H1VSY4"/>
    <dbReference type="GeneID" id="28861437"/>
    <dbReference type="KEGG" id="chig:CH63R_02355"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02355"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_508064_0_0_1"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43342.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR13629.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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        </source>
    </evidence>
    <sequence length="536" mass="58483" checksum="1E4FEA9183534A30" modified="2012-03-21" version="1">MRAQDTPELFVKDMYRGFAKALTGLCEMYGNEDLKLAPYLLAEDQEAIGMLPLCDPQLPGSCRLNYNEDTGSLKPQVEHYGGQKLSGLQETFSRVLDTIKCGFFLANDDTDFPFTYTSSPKGLTFKHEEDYTPKPEVVAAITQPSVAGNAPAEVVIAHRERPQHSSRAKNTSPSSTPSVSHHDAAPPQVHSHSTPGRQKVQGQSESHPTPGRNRAQGQSEYDFSSDADMLHMVNDFLMPPQAHMSSTESHEETSYGMNSVMANEVFGVPPTNSPPALGSATAKTFPSLPWNMIYTPTPQGKNSELTPPDRAIRDAAARQSFDGSADPKRNVSASGHAMFDDPFADFRENQYLPQRQQQAQQRPFASTPDITAHQDRLLQAFGKQPTDSRSMSRDFSGAGYGLWGTPYAELNPNTLQPRASSTHARSLSASRHQYAQSPSMVQGAAENFLPSSGTQFSNVSGIYQSTPCNGINYTATTAFGRGPIADMREDPTHYKNLVRQNGGAATDGYTAGYNDMILQSAMADEMKRASGPSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VX28</accession>
    <name>H1VX28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von willebrand factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03428</name>
        <name evidence="3" type="ORF">CH63R_12882</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007179">
        <property type="protein sequence ID" value="CCF44790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152273.1">
        <property type="nucleotide sequence ID" value="XM_018307856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VX28"/>
    <dbReference type="STRING" id="759273.H1VX28"/>
    <dbReference type="GeneID" id="28871963"/>
    <dbReference type="KEGG" id="chig:CH63R_12882"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12882"/>
    <dbReference type="eggNOG" id="ENOG502S84A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093522_0_0_1"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF44790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="243" mass="24897" checksum="1801607D18B14DB5" modified="2012-03-21" version="1">MRPPVGYIPRLYAPLVTLTRQSFRPSPALTAVRAATATTRSNSRTSTSSGTQSRTMGAPAPAAASEAANGSAAAASAAGGRAETQNQPLEDGSHHEHHPTESTSPAPENTTFNAPAADDSNTDSSQRQPHAQRPTEPAQQKQPPALPPLPEPSLSGGNSAGGGGSGSITLDMSGGDGASTKLDHLGPLVVNQDGTMSRIGNWGEMTEIERRNTLRILGKRNQIRLAALKGEQGNGAGNGASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYA4</accession>
    <name>H1VYA4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_03543</name>
        <name evidence="4" type="ORF">CH63R_01046</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007534">
        <property type="protein sequence ID" value="CCF45216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164383.1">
        <property type="nucleotide sequence ID" value="XM_018296021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYA4"/>
    <dbReference type="STRING" id="759273.H1VYA4"/>
    <dbReference type="GeneID" id="28860128"/>
    <dbReference type="KEGG" id="chig:CH63R_01046"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01046"/>
    <dbReference type="eggNOG" id="ENOG502QVRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005537_0_0_1"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1146" mass="125969" checksum="F7CE304BFB72A79E" modified="2012-03-21" version="1">MASTYAVPPASLHDGQAGEPHNPSPPNGNQRLPITSFGPNHLSPSSQFQGSSVSPSFGETPAESISNFSQYQPSDYSDIDDGLDPFFGVSFSTTEHGTPSFLDPANRTDSFGQSTVSQAFNGSQVRSRKLDANTYPLTPDQASLHTTSPGRDRRTVAKSVPDGMPTSISPQELQKPFQPHPISTFAVQSAPQLTPNTSGSGRSSEDSGVPSPAMVAAQSPRVTVSMWGRDAAEPVQSIERTFTPDDENSSPAHGDISFAGDLIPSQEPAVAMPSPRRSSFARQGLDPGNRPVTEIASVNEMVTRREIEEKNQEVDQWLSRSLHGAPVALPPHQDTNLHTSPEAMAEDEYIRLGDRTENRYQPGQTYFTARGGEMTATDLHIMRSNRVWGDSPMVHPISGPDAERYQPESSQAAIARFRQMCDNESIVSKAATWGTRRRSLPSVIDMDMENVTSGNLLKKLSISRGEGGRRPSILKDLRGLVRRPSAHRLKRSISTHGDENVKSEPPPPEKRESLPHLLPTARTGSWSKPKTQTPSINTALVSMGNRVASIGTTHARNGSIGGTTVTSPKSPLSPFASLQVKNTLRRPRSKSDLPKSSGAETHSSLVGMWRKTGGPPVAVLAKGNSTNVDLDDDDDEEDELYEDGDLNAESSKLIEGVSPNFAGFQQHVLRLNPELATTNNYLVDRIAHQQVVRYKSLLNAKVKHLGLGQACSCGTFCSARGGRPVLLDHRGDVRDLDPLSTGFDSGDGDSTPVEGAITKESFPRDIPMPPTQSLPAEFECQLCFTLKKPKKPSDWTKHVHEDVQPFTCTWDRCREPKIFKRKADWVRHENEGHRHLEWWTCDVEDCRHTCYRRDNFLQHLVREHKFIEPKNKTKAAIKRAGAVDPTWQRVEQCRHETSKKPQEEPCRFCGKQFPTWKKLTVHLAKHMEHLSLPILRLVAAKELEPDTIISPVQDPPPRAPFSALEPLDESTIKSEPSQMRIFTHPSSYQPPAMMPSSNGAYQDGNQFGYAGVASNPPFQDYMYTSQFPNNSQPMAQNMMGVLPVDGGAQGFTQQYHKANDMGIPGASYMGTQQQYMSVAQDTEPFPALDHNALGLHQPNPMGVSMGYNGLVEPGAVNEHQYTSQGSISPYSHSPLQRGSGFYPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYB5</accession>
    <name>H1VYB5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_14376</name>
        <name evidence="9" type="ORF">CH63R_01458</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02007546">
        <property type="protein sequence ID" value="CCF45227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164795.1">
        <property type="nucleotide sequence ID" value="XM_018296433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYB5"/>
    <dbReference type="GeneID" id="28860540"/>
    <dbReference type="KEGG" id="chig:CH63R_01458"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01458"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF45227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="56670" checksum="1FC78AC233791485" modified="2012-03-21" version="1">MDSSSGSSSSSPEGPVTTTLVPHDLPELLEGLSKDELAALEKKLIRRLDTRMLPTMILMYIMNYLDRNAIGAARLGGLEEELGLTGSQFQTCVSILFVGYILMQVPSNMLLNKIGRPALYLTGCMAVWGVLCACSGATTNYAGLLVTRFLLGFVQAAFYPGESDDPTGTKSNFGKKRDSPPHNIMARTGCIATLSSWYVRKELGLRTGLFYTGSMLSGAFSGLLAAGILSGMDGTLGLLAWRWIFITEGTLTVVIALGALFVLPDFPANTRWLTEQERQLAVWRLEIDAAGEEDWTGSSSSSQPLFDGFRMLVVDPVNWILVLVVYGAASSISINSFFPTIVGGLGRDRIATLLLTSPPYLLACFVCAAVSWNAGRTGERYWHTVGPLACALVGFVVSSAATGVAPRYLGAMVMLPGIYTGFNMSMFWTANTIYRPAAKRAAAVAFNNAVSTLSSIYGSYLYPSHAAPRFVLAFSVNAGMAFMAIVASTALHFVLKGENRKLALRDQEAETDGRTVLVGKGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VZR6</accession>
    <name>H1VZR6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00572</name>
        <name evidence="3" type="ORF">CH63R_01555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02008012">
        <property type="protein sequence ID" value="CCF45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SI27">
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    <dbReference type="InterPro" id="IPR021840">
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    </dbReference>
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        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
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        </location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="486"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF45728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16375.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF45975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H1W0G2"/>
    <dbReference type="STRING" id="759273.H1W0G2"/>
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        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF45975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="219" mass="24317" checksum="C397F71BD351F697" modified="2012-03-21" version="1">MTTASPFPFPREYSFPPFFTRQTNLTTHHAQLVKWSDLILAYCRHHRIFKLSLGAAIPSASSALPHALPNHNAAASSSPHNEPTTFSPATAASSAAAAPEELFHNRALNKRLSLADAREVLEFMRKDGRAEPLPASTDVFWIYWRTPDEWASVVEGWIDETAQKGVVLTLYELTEGESTRGTEFHGLDPDLLAKALQILVKRGKAQIFGQEDSQGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1W1N1</accession>
    <name>H1W1N1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylserotonin methytransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_03860</name>
        <name evidence="5" type="ORF">CH63R_05814</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CACQ02008656">
        <property type="protein sequence ID" value="CCF46394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158639.1">
        <property type="nucleotide sequence ID" value="XM_018300789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W1N1"/>
    <dbReference type="STRING" id="759273.H1W1N1"/>
    <dbReference type="GeneID" id="28864896"/>
    <dbReference type="KEGG" id="chig:CH63R_05814"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05814"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF46394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="279" mass="30446" checksum="BD3A7A6F50BAEE49" modified="2012-03-21" version="1">MGEAKNSSDHPPEYVKASEHLNRPRAPSAAAGGPGPRGPLPLNLPIISYLKSKRVILASASPRRRALLAQVGLTGLEITPSTKPEDLDKSAYGPYEYVSETARKKCLDVYETALQTHLASIPDPDVVIAADTVIVTRDGRVLEKPRSEAEHIKMLRHLRDTRVHRVLTSVCVIAPREDARSPGYEISIHTEETKVYFAQETNGLPDDVIDAYVKTREGADKAGGYAVQGIGGMLLVEKIEGSFDNVVGLPVRQTLALAEKVVFKQGGDEVDEEEEEDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5B6</accession>
    <name>H1W5B6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mmc protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00690</name>
        <name evidence="3" type="ORF">CH63R_09017</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02010012">
        <property type="protein sequence ID" value="CCF47680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156014.1">
        <property type="nucleotide sequence ID" value="XM_018303991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5B6"/>
    <dbReference type="STRING" id="759273.H1W5B6"/>
    <dbReference type="GeneID" id="28868098"/>
    <dbReference type="KEGG" id="chig:CH63R_09017"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09017"/>
    <dbReference type="eggNOG" id="ENOG502S7XK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092869_4_0_1"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555864" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF47680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="141" mass="14063" checksum="A9DF83DCCD3060D1" modified="2012-03-21" version="1">MKFSAAALVLAAGAMAHKNVTYVTEVVSSYTTYCPGPTVITHADKTYTITSATTLTITDCPCTVTKPIITSSVVKCDNCVHPTKNATLPVATPPVSKTTIAGTAAITPTKPISVPTAGAGKAAALSGAGLAGVLGLAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5K7</accession>
    <name>H1W5K7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_00699</name>
        <name evidence="19" type="ORF">CH63R_06391</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="CACQ02010123">
        <property type="protein sequence ID" value="CCF47771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159216.1">
        <property type="nucleotide sequence ID" value="XM_018301366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5K7"/>
    <dbReference type="STRING" id="759273.H1W5K7"/>
    <dbReference type="GeneID" id="28865473"/>
    <dbReference type="KEGG" id="chig:CH63R_06391"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06391"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005327_0_3_1"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="544"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="848"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF47771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124580" checksum="139A8A59C1037531" modified="2012-03-21" version="1">MASAQLTEEELQQSAILSEEDAEFEDAPCIPADQIPQTTESPLTNPNTHDDELSDAVGDEDNQGDASVIENDVEMGEYPDDNSELSEQESLDEELEIHSQGDMDRHTEQDERDDASGGARSRSSSLLDDIEEDEAEGVGAVKIRPGETDDEDADDPESDHTDSHSESANESEEDAAWDEVAAAGEDDEEGSEDAAPNTCMFCKQDEEHDPAEDFEEFLTCVDCGENSHQHCARAAGALQDLNSASQWKCLDCASEDQAPVDDAQGDATLKQERDNADEHYKDKEREPELDVDLSPSSRRSTASQVARDLLPAQKGTIKPDSHSVFNHLLLDGDPMDGSRVLRKRKTSSVEADDVVVSLRKRRRNVSKERDSSQGAGTSQDGPNGIKEKDSRRKLRLNPARKAQAVTITRRSRSIIVKMRVKTSALRRALSRKSESSRRRVERAGTAASSHDGLTAAMTGSFTSSDYTHPFYSFFDRETDDVKTKPYGGILSETEADTSRTLPTNDDRRRFDEAKQKAEEVWRARLQSAQLNLATPAKRSKKNSGPASQIECIDFGGWEIDTWYAAPYPEEYSRNRTLYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYRHGSVSVFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVLCEYDALGYHFVGYFSKEKRASSQNNVSCILTLPIHQRKGYGNLLIDFSYLLTRVERKTGSPEKPLSDMGLVSYRNYWRLVLCRYLLDHVEEDKSAAPGLSIRQMSDDTGLTPDDVISALEGLRCLVRDPQTELYAFRVDIAYCNEYIAKWEAKDYVKLNPDSLTWTPYVMGRGNATNFELGPAISAIAPREEDDSQKPAHETLPPTSQQDPTTNGLPTKDIANSPHTPDGASFASTEGVGKDVNGSKAGNDVYESTESHHDGLLLNGNTVKEQAHEEASRRSEVPHPTTPGPPVGQDWAGMYKNVPPSRFEVYPPPGGRRSDRPRPSVPRPSVARNTSNSSRPRRSGGGSSVRRPTATRPKSKSSSSSSRRKTGGTGRGPGRWPKGTKKSDYGNADSGPGLPPGWVKDKQQLASLGVAKGQEVEGLTSESKETIDVVRVQFEKGAQDAASGNVAGGYHGSHGNADGRTDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQP1</accession>
    <name>A0A1B7XQP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150589.1">
        <property type="nucleotide sequence ID" value="XM_018309617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQP1"/>
    <dbReference type="GeneID" id="28873724"/>
    <dbReference type="KEGG" id="chig:CH63R_14643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14643"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="447" mass="49574" checksum="8B6A5D5A906AD27A" modified="2016-11-02" version="1">MSRPPDKYSQKNHERRVLYLKEKWPGGQFIPAQFVHKEPGRDLVSDLYTITRIYTESGIPLHHMWEPASPDNPARGLLRRHMTQKGAHFITNSIGLEARKEATRKGWPATEMATPSTEPEAHNPETSGSHGDKANETPPGGVVGQRNHGVEADNGDEGSEDEDCEDNIEGDTCLGSPSAKSSGQTAGGKRKHDMVGPSPSALSQGTTVTADGRSTKSRRISGMHDEPDNLLSYIAKVDTEYADSLHRTFSQAPRVLAKLLNEAKKTKQKLAMLRLEVENKSSGGQVDQEMELLVDADDDAAAGDRPGRTQPSRHLDPLVAAERELGDITRKRAELEGQIGKLDTEVFSLGQIIDSLSRQLSESSQDISAVRQHSMLQMNREFLEKAQKERADMHVRVGEWSQREMAVRHRRDGVGDAQMQIELLEERLDRCEQAVAVVECQWNALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSB7</accession>
    <name>A0A1B7XSB7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_13889</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151181.1">
        <property type="nucleotide sequence ID" value="XM_018308863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSB7"/>
    <dbReference type="GeneID" id="28872970"/>
    <dbReference type="KEGG" id="chig:CH63R_13889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13889"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR02663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="56991" checksum="75F9AFFFDA5F0427" modified="2016-11-02" version="1">MGVIRKKTVTRGGEGGVKYHCDICSVDITSTSSSNHKPESHPYRVIEQNSFPIFDRDWGADEELLLLEGAEIYGLGSWADIADHIGGFRHKDEVRDHYLKVYVDSPRFPLPKRCSPNDMDLANEISREDFQAKKKRRIEERKEAAKNAPTLQPKTKPTASVPSCHEIQGYMPGRLEFETEYANEAEEAVQLMQFDPGDGLNPRTGELEPEMELKLTVMDIYNCRLTQRVDRKKVVFEHNLLEYRENTKVEKKRSKEERDLLNKAKPFARMMNHDDFESLCQGLIDELNLRQAIQQLQEWRSVRIGDLRSGEKYETEKAQRAQKAIPMGSMDRDRLASAQRSKAAAVPDPPSGAALLVAPELPIRSAPAPDGTNGTIPPKEANGDSNPQANGALNGASTNGTVVVANGAAPSGPITRQKYMAAALPGVTPLQLTQDGAPDLHLLTPEEAKLCEVVRLQPKPYLMIKEQILKEALKTNGTLKKKQAKEICRLDSQKGGRIFDFFINAGWVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XST1</accession>
    <name>A0A1B7XST1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_14045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151337.1">
        <property type="nucleotide sequence ID" value="XM_018309019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XST1"/>
    <dbReference type="GeneID" id="28873126"/>
    <dbReference type="KEGG" id="chig:CH63R_14045"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14045"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR02819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="63" mass="6926" checksum="FDFD384560AA7A53" modified="2016-11-02" version="1">MKRLSVVYLWARGRRLQMNEGEAMPEMPHARDAGLLGVVLSSRSGAFCSSARTRDAADVPHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTT9</accession>
    <name>A0A1B7XTT9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151693.1">
        <property type="nucleotide sequence ID" value="XM_018307276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTT9"/>
    <dbReference type="GeneID" id="28871383"/>
    <dbReference type="KEGG" id="chig:CH63R_12302"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12302"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="365" mass="40739" checksum="C7A1A1308AA5730D" modified="2016-11-02" version="1">MAEVSHPAGSPQHSPAPAERRGSPESTPAPTSVEENALPPAEPLPTLTSELEPGLQIEVDAADASDVDSALDVPTRDSLTSLRSSLRQYQHENGRTYHAMSAGKYFLPNDESEVDRLDLQHYVMTLTLGGNHCLCPKNRGAKRVLDLGTGTGIWSVEYADAHPEAEVIGVDLSPVQPDLVPPNCSFELDDLEKDWTWSRPFDFIFCRMMTGSFSDNMSIVQKVFDALEPGGYFEAQDMALPLGCDDGTLTVDSDLWKWVLLVMEGMEKFGRPVSAAQQWKQLMEAVGFVDVVETIYKWPTNRWPRDQHYKELGMWSLENMDQALEPATLAPLTRALGWTYEEVIVLVSKARKVMRDPTVHAYWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XUS4</accession>
    <name>A0A1B7XUS4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_12617</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152008.1">
        <property type="nucleotide sequence ID" value="XM_018307591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XUS4"/>
    <dbReference type="GeneID" id="28871698"/>
    <dbReference type="KEGG" id="chig:CH63R_12617"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12617"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="409"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="527"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="634"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="361"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="727" mass="78859" checksum="EF4BB8C6B157F1DB" modified="2016-11-02" version="1">MGVTEWVAERQMEVEESQNQRDKRVEDLWRQLDPNGSGHLDFKGLQKGLRKIDHPMKNADHMLRKIMTVVDTNDDGKIQYEGESSVAWDWSYWPGSPVLRRLREIAADDDLPPEFRCFVEQTERQLMFLFQSIDKDNDGRLDKTELQEAFRRAGLVVPMRKLASFFGDIDMNNDGYISFEEWRHAPLKAVMDFYSSIVTLSAEGDSMVSEETLEGSGTTGFLLQTLFGSILKLASPSYSDPSAGNIQLLSDEDGNSVAVVVPSREGPGSGPPGLSQLPASPKQQRRRSLSKNNNSDSNNSSSGYATASADLDPASSQQQTSSAQAMVLPISPPGYSGTSANMNNMNMEAAVLQACIQAADEKPTGIPGRPPGVGTSQANQVTGSSSEQGSSSSSDATVAPKFKRLTDFVPDPGYFIAGAVAGGLSRTATAPLDRLKVYLLVNTRASTDTAASALKQGRPLLALRNAVKPFGDAVKDLWKAGGMRSLFAGNGLNVIKIMPESAIKFGSYEAAKRTLSKLEGHNDPRQINSYSKFVAGGVAGMVAQFCVYPLDTLKFRLQTSTVQGGLSGNALVLDTAKKMWQAGGVRIAYRGVTMGLMGMFPYSAIDMGTFEFLKTSYKRYMSKYRGIHEEDAKPGNIMTGIIGATSGAFGASVVYPLNVLRTRLQTQGTVMHPATYTGIMDVAQQTLKNEGVRGMYKGLTPNLLKVAPALSITWVVYENSKRLLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVE5</accession>
    <name>A0A1B7XVE5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_12845</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152236.1">
        <property type="nucleotide sequence ID" value="XM_018307819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVE5"/>
    <dbReference type="GeneID" id="28871926"/>
    <dbReference type="KEGG" id="chig:CH63R_12845"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12845"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="289"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="823"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="885" mass="96658" checksum="DBF9AB5A90DB13B1" modified="2016-11-02" version="1">MNGDLSLSRALGGLRIANPDDTDASPNTAQDADTPLRPTDHQPDHQSDAGLAPLDDPTAQRATTPYRSTPTTSDSLLPPISNTQAPEGPSSAYDGSPSHVESHRTSPSAAMRADVYRQPVSPYSDLDRAPDSRTSASPTQRPISGLYSQPSMVQEDGRAPHLAHPQADRSRNSVYELLARQDSRIASGYQGGSTPTRELSHRERSSNPARQSELPPSSSPLPPRRSSKGMAGGYVSAAAGPRDPYGPEMPLPSSSEEWKDRGAAVGVRRETDANGKTVIRHVKKGVRDFSFGRVLGEGSYSTVYLATDRQTLKEYAIKVLEKKHIIKEKKIKYVNIEKNTLNRLTEHPGIVRLYYTFQDEASLYYVLDLCNGGELLGVLKKTGSFDLECTRFYGAQILDAIDYMHSRGVIHRDLKPENVLLDDHMHVKITDFGTAKLLKDPREAQTAGEGARGLPENSRGDAEDDSRAASFVGTAEYVSPELLTSKNACKASDLWAFGCIVYQLLAGRPPFKAATEYLTFQKIVNLEYDFPAGFPPAARDLVERCLVLDPARRLTVEHIKNHEFFDGQQFGKGLWRTKAPRLRPYNPIPQEPTVIQLNGSANSPNPVNTPRSSQPQSSAMNSSSRPARIITELPPPTQLDIEWSPVLTKNNERILKLGDLMVVSSPLPAGGHSRGGEHGEGHKKLSRFFGGSTTKKRQRLVMVTSSGRILLAPAGGEEKRAKQEISLLAPDCSWRTQLDVKGQTVWCVDAVSILDKKSRRSSKIRQGGVHYTFEEPKGSSNSSENGSTANDWIESLERAKELALSQNPTGSYAGDNGFDMSSAVSSPSSTLGGRAGAYPDGFSVSDRSGRNHLSKSQASLEESASNTKRNRFSKRQSKNGLGQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX84</accession>
    <name>A0A1B7XX84_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152887.1">
        <property type="nucleotide sequence ID" value="XM_018306046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX84"/>
    <dbReference type="GeneID" id="28870153"/>
    <dbReference type="KEGG" id="chig:CH63R_11072"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11072"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="38606" checksum="3396E2CAFF37A630" modified="2016-11-02" version="1">MGAAEQQQQPPRVLILDGGLGTSLEDKYNIKFESATTPLWSTHLLVDGQDTLLACQKDFGDVPVDIILTATYQLSIHGFASTRTAKYPQGIDRATIGNFIQDAIRIAHEAGRTQASKTALSVGPYGACMIPGQEYSGAYDAEHDSLDKLREWHLERLQLFKDAGAFASPVSYVAVETIPRADEIKAVRQALDESGVLATQASIPFWIASLFPREDECLPDGSSIKEAVTAMLSPDVATSRPWGIGINCTKVWKLESLVKGYESAVQGLIDDGAIAEAPALILYPDGTNGEVYNTTTQKWELPEGSSHPATSWETQLSQVVANAQSRGLWKQIVVGGCCKASHSDISRLRTAVKGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXC5</accession>
    <name>A0A1B7XXC5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152945.1">
        <property type="nucleotide sequence ID" value="XM_018306104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXC5"/>
    <dbReference type="GeneID" id="28870211"/>
    <dbReference type="KEGG" id="chig:CH63R_11130"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11130"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601163" evidence="1">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="243" mass="25581" checksum="79B2CE236C85CBE4" modified="2016-11-02" version="1">MKFTTILSVGMLLLGVAEAQVCYRCFYTRNIGCGACNDKTTKYDGEGGDTYWVTSALEVVLPETANWCTAVAPPALFLAAAASAPVLQWDPTARSSMPSTAGAPRARYWQVGISRRAGPAPDDTSFPRNRSLGHMQTVEPSAGVPLSGGGRTRRRRRRWRLVVGDVVDWEAVRQSQADDLAGGVVVSRPDSGAQAHVGDEVAVVEDGVGGGEAEALVRQGAGDDKAETLGLRTMGVAALASCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXK8</accession>
    <name>A0A1B7XXK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153007.1">
        <property type="nucleotide sequence ID" value="XM_018306166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXK8"/>
    <dbReference type="GeneID" id="28870273"/>
    <dbReference type="KEGG" id="chig:CH63R_11192"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11192"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="595" mass="64796" checksum="CCF9E8DC467E04DB" modified="2016-11-02" version="1">MSVVTKHAGRTNTPDPGESEKIKETCALADGRILFSSFQGVAFMIIHLVFFFSLHGKPVESSFVGQSLQSAIANFLAIAVEICLLSGLGVAYDQLLWRLFRNKALPAVTIDKLIRLATSPWNLPRPGIFLAAPEPWLVAFLCLLVPLAIVFPPGALTVEYREAVQPVTLHDVPTMNISDWGNGTAHDLYHHALFEIPGELMTSTSSRAILQLESVADRVLASGEPVPLRLPCKGTCNYTSTIEGPKFNCRQASLTELPEYSQRSANGTLEPFTKCRGGDVFLAWDEAEMELKIEDSFKVAWFPIKGGSCVPNATMKAMACSTALATYRLTIATFQNGSRDIRASILNETAISTGKPMGTSLHEYFPGEKFVNESKAAQDDLTTQFRILQALAIRQAAVQSLTGSILYKYDLFPGVPALVVNGTRAAGSPYIGIRNKFGMDVNITAESLQSYLQDVLISSISLNWLQPETLWTYSEPIEGFEGAAVYLFSEPWQFYAPYGSCLAVTTIVYLLGYQALRRNGSSAGNSFLQIVSTTSPGGILRELGEECSSGGSENFSKEFKGVKLRFGIKRMDEGPEATKSDGAVTLLGTEAEIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYI9</accession>
    <name>A0A1B7XYI9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PdmS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153361.1">
        <property type="nucleotide sequence ID" value="XM_018306520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYI9"/>
    <dbReference type="GeneID" id="28870627"/>
    <dbReference type="KEGG" id="chig:CH63R_11546"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11546"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000072">
        <property type="entry name" value="Glycosyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="305"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="439" mass="47128" checksum="2BA55C6F7CFBCCB7" modified="2016-11-02" version="1">MKVLIATMPFAGHINPAQPVARALIRRGHAVAWLTSASHEHLVTPTGAAFFPSPAALARHDEIPLAPDPGTWGLAAVVSTLRRLFLDRVPDQVAAYRAVLATFDADVLLVDLGAYGAHCLRDLTGLPYATLGINPLFTMDAEIPPWGTGWLPPKTFFGRWVNALTHTVAAQLIYTRLTAALNGHRAAMGLPPLPALGFYDSTRSDALHIMPTTPAFEFPRRNLHPGVRFVGPLLPLFNDDDEGDDGGGGGGTFSPPEWWGELLAHPREKVVHVTQGTYATNPANLIAPTLSALRYRPDLLVIATTRDAETLLAAGSLPANARVAPFVPHARLLPHVGVMVTNAGYNGVLAALSCGVPMVCAGRSEDKADVSSRVAWVGAGVDLRTDTPGEEALRDAVERVVSDGRFRKAVEAVRNDFARHDGPEEAVDELEELVEKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZF3</accession>
    <name>A0A1B7XZF3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153671.1">
        <property type="nucleotide sequence ID" value="XM_018306830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZF3"/>
    <dbReference type="GeneID" id="28870937"/>
    <dbReference type="KEGG" id="chig:CH63R_11856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11856"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="352"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="501" mass="55900" checksum="7AB76AB8352858A5" modified="2016-11-02" version="1">MPPGTRPTRARIVSNENDENSGSMRMTRAKAAALNVDELAAPGKAALATKKPAVNANPAGQRKRAALGDVSNVNKTETAVPGKKPASKSGLVSKAAQPTGITKKSSTATTRNAVPKEKKAPGSGSGAIPKRKPINVSSNANAAKDDNLLAEGEPLRKKHYATQPTEKRRAKPEPELPPSTAPVESVPAGSNKPFTYPSGVRNLDEEDLDDPLMVAEYANEIFEYLRDLECNSIPNPNYMEHQDDLEWKTRGILVDWLIEVHTRFHLLPETLFLAINIIDRFLSEKVVQLDRLQLVGITAMFIASKYEEVLSPHVANFRHVADDGFSEAEILSAERFVLGTLNYDLSYPNPMNFLRRISKADNYDIQCRTIGKYLMEISLLDHRFMAYRPSHVAAGAMYLARLILDRGDWDATIAFYAGYTEDEIEPVIRLMVDYLARPVVHEAFFKKYASKKFLKASILTRQWAKKSAEHFGVVDVHLSLDQISTREEDNYPEEDEEQDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y004</accession>
    <name>A0A1B7Y004_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153866.1">
        <property type="nucleotide sequence ID" value="XM_018307025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y004"/>
    <dbReference type="GeneID" id="28871132"/>
    <dbReference type="KEGG" id="chig:CH63R_12051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12051"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="68" mass="7616" checksum="1F72BB98D9677B39" modified="2016-11-02" version="1">MARVPGRQSSLPPLHHSTTTRCWPSVGHVPYLGCRNRTFNLPRVQRLAVLATLIIGHPPSPRRPKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0G6</accession>
    <name>A0A1B7Y0G6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_12178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153993.1">
        <property type="nucleotide sequence ID" value="XM_018307152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0G6"/>
    <dbReference type="GeneID" id="28871259"/>
    <dbReference type="KEGG" id="chig:CH63R_12178"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12178"/>
    <dbReference type="OrthoDB" id="4823993at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="272" mass="30596" checksum="DC59D8EBCE74CADD" modified="2016-11-02" version="1">MMLSKGYSLLKVKSEMELDPEAEEPAIIPKSRMASFQFNLAGLACRSTCFVLFITGVVIIVSTLGWTPSDRYCAAQLSIWSPLLEAVEYEERDWENTYIIGDSGFTGPPTAELEAKWINVSQVPALVIPPERVSSLNRNFEQGFVPVSSSSPSSGYIAGIEVFHHLHCLNALRQYVWRDSYPEDMVPDLLKSMEGARKHAQHCIETLRQALMCTSDITPYLIYKTEDPSPGSEPAREDFQASHKCRKFPKLLEWVMDNGIPLSELTALREDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0M9</accession>
    <name>A0A1B7Y0M9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154084.1">
        <property type="nucleotide sequence ID" value="XM_018307243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0M9"/>
    <dbReference type="GeneID" id="28871350"/>
    <dbReference type="KEGG" id="chig:CH63R_12269"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12269"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR05566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="747" mass="83261" checksum="B65F9BF94D3974EF" modified="2016-11-02" version="1">MNSTALSIASDEGDVSWSDNHSYSSDDNMQDDLLIPHSPASQTTPAWMNSAAISHSDNCQLSPVSAAIDISTMNPSCAPTMVHSASSSCTDSWSNSHAEVFDGDDADNDLVWEQDSDDILTAPKLEPLDDDFNLDDVTEAPSATTQAPFVAAANQPKQKRPRGRPRKHPVAPIINPSKVTKGRSKTGCITCRRRKKKCDEAKPRCMNCEKNAVVCEGYHEKKLWRSGKEKATTDHLGDEESLVFTMQPLFNGVDTVEDKIFWRHYGVHLSNVLTVEGEAKNAFKDVILPLANLHQGVMHSILAMSSKHIDFETPYGAKLLEKNPTTNREALQARSAYHEEQAMKTLYADMNRTGDDNDDGTDRQTILSARYAQILCLVVTTLIEGEPHGAHRVHLGGYKRLIQESPPEDPVFLAFITEFFQYHIYADELLWHPTRNCPRLASEGWSSLVPLDSPRLLGVADGLFHHLCHITTIRNTIRENIYRGADTVVTYHILYQAQEIQEAIEQWMPTWPTGDSRHRVGLVYKHMMFLHLFRTIYPPTSPQRRHSVLSVATSVATSVSSFSSRRHSQISRPSTATSCASSPSLRPTTAAGFPSSMQPKREPSSRGPSRTSSMHESDAGSSSCAIIDEQRPASPPPIRRPPQHDNRITSAVDESLAIMEGFKPSDPALTLLLMPSLVIGTTCFEPAQQERIRAIVRSVRGYTGLRNCDRVLEVLEEIWHLMEFGDWVSVWDWQGVARRLGLDFLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0R1</accession>
    <name>A0A1B7Y0R1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mus38-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154116.1">
        <property type="nucleotide sequence ID" value="XM_018304692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0R1"/>
    <dbReference type="GeneID" id="28868799"/>
    <dbReference type="KEGG" id="chig:CH63R_09718"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09718"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27761" checksum="062A8AB0A2908E27" modified="2016-11-02" version="1">MATAQTLAVIDIPGLHHSPSVEDFADSRNVSNGLPQPEEQPEISDTVLKNLGELFVRHDAHGAFGIHLLHAHFQVPEGHVLFGIQVQVSGNSESCWTKPVPAKELTTKPIHGHVFHLQPNGAFVPYEFQEGEAPSNASKVPKAFFQELAEFLHLKNLAGLVALQLLDGPRDRTQTELLVGPQGTLMMDTKDVLGFEPAQITTGWFFQVGEDGIISCKGNDVYAAKKNTHAVFRDSKPLPTVEALKAVLLQEGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y143</accession>
    <name>A0A1B7Y143_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_09840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154238.1">
        <property type="nucleotide sequence ID" value="XM_018304814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y143"/>
    <dbReference type="GeneID" id="28868921"/>
    <dbReference type="KEGG" id="chig:CH63R_09840"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09840"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="506" mass="55857" checksum="30C9168799730844" modified="2016-11-02" version="1">MSATTDLPPEKALETPVNDASGADSPSEVENGDEGVNTKALLRKLDAKLLPAVGILTDRTVNSRADPRWPDGDDSNVVTVGNARIEGLTEDLHMSGNQYLTGLTLYFIGYVLFEIPCNIILKRTTPRFWLPTLTVAWGIVATLMGIVTNMAGFFVARFFLGVTESGLFPGVVYYFSMWYKRRERQYRISLFFSAASLAGAFGGILAWGIGHMRVVWDNGWRWIFILEGIATVVIAIGAYWFIQNYPDTAKFVSDKERRFIRARLAADSDATHNEKFTWGNVMDAIKDPKCWLYGLGFHTMSLPLYTFSLFIPTIIRNLGYTAAVAQLLTIPPYAVAFVTTLTVAIYSERTGRRAFFIMGSSAFAAIGYIILLANGDPTGKPGVSYLGTFFAAAGIYPSTALVLSWPAINVSGQTKRAVGNAMQITIGNLGAVLGTQLYRANDGPRYFVGHSFALGYLIANIVVCGILYIVLKRENTRREAIAPEVQAIGDLEDWPGDKDPRWRFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1G5</accession>
    <name>A0A1B7Y1G5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154374.1">
        <property type="nucleotide sequence ID" value="XM_018304950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1G5"/>
    <dbReference type="GeneID" id="28869057"/>
    <dbReference type="KEGG" id="chig:CH63R_09976"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09976"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="495" mass="53515" checksum="1ECE999820169ECD" modified="2016-11-02" version="1">MATASSSADHVDVARNQGEGGAREHNRQDANTDVSNLPGNVESLIHLDGTARQIEIQIRGHPEHWSNRTFVFIMVAQNLGSFAACSGWVAFANSRNHVNTELRLPENDHQLSTMWLLGSSIGFLLVGRLSDLFGRRWFIVCASFLGAIGSILGWFGSSIGVHIAANICNGIAAAAQISFAFVVGELVPVEVRALYFPATLLAPCVAAFVLPAVTPTASLDNTTAWRRNYCLGTICAFFSAWIYLWCYFPPSYRQLNVAGGSMLQMVKSVDIIGIFFFIFGCVLTLFGLSCIGPAYQWGRYEVVGMLLGGGTSFLAFFIHEVFFCRTQALLPPKLFRNRHYVALVNNAVFASMTYSVVYVLWPTIVGKVFDENPDAISNAIAWQAAILGGSLWYGMALAGTFLSLFHLAKSICLISASVAMIVLGCLGGMQLDELIQITVLVALLCVAIGFIENVAITGVTYVWDAQDIGLAFGVLGCLCSLSCAFAQVGFASILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1N5</accession>
    <name>A0A1B7Y1N5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf1620 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154437.1">
        <property type="nucleotide sequence ID" value="XM_018305013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1N5"/>
    <dbReference type="GeneID" id="28869120"/>
    <dbReference type="KEGG" id="chig:CH63R_10039"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10039"/>
    <dbReference type="OrthoDB" id="5347452at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="425" mass="45059" checksum="7AC6556FFEC56AC2" modified="2016-11-02" version="1">MASSSRYIAGLAVLSSLANAKVYKMPEATTSFDFPLDKFSPQPTKAPAYADLRRRQTSTTTTVLVAPDNTCGYISGRAGAAYTCGSSASCIFFTAVDRSTPGRVACCGTQECGARRTCYDSRQVSSSSLCDGGCLVDRFTLKCTNTARPYCNTISFSESIFDYWCNTAEISTPQAAFTTYEGQSAREWSPLALTDDPTSTSSGRTTSSTVTTTVEPGPVTSTSAPDPDNDTKSVPIGAIVGGVVGGVAVIALVSLAIWFLLRKKKQNPQGQQQQQQQQPPMNQQHMSYAPGPGPHGSPPQNAAITHTQSFYDPKFGGQGGYPQSFGGTPPPPQQGGYQQPYYGGNMAVPDRADTTSPGAVSQMTHNRLSTQPQPQPVSPSGTPGGFQQYGQQPQQPLQPQQPPPATIHEAPTNGDGHRGHMHELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y257</accession>
    <name>A0A1B7Y257_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154595.1">
        <property type="nucleotide sequence ID" value="XM_018305171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y257"/>
    <dbReference type="GeneID" id="28869278"/>
    <dbReference type="KEGG" id="chig:CH63R_10197"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10197"/>
    <dbReference type="OrthoDB" id="3943049at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="71" mass="7970" checksum="DDB762892E9D6E51" modified="2016-11-02" version="1">MGQFDWFRSIGATPEAVAVLNDQPILFTILLIVLFAVTLQGVLLWYIHFATLKPEQRKKKEPTKGGKGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2K3</accession>
    <name>A0A1B7Y2K3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">V-type proton ATPase subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_10362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154760.1">
        <property type="nucleotide sequence ID" value="XM_018305336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2K3"/>
    <dbReference type="GeneID" id="28869443"/>
    <dbReference type="KEGG" id="chig:CH63R_10362"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10362"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="954" mass="104496" checksum="2D76736A8BE493A3" modified="2016-11-02" version="1">MLATIRPAICRACRRAQIRPARGFATASGPIQQPPRDNYVKLVEVGPRDGLQNEKKTIPLGTKIELIERLAKTGVSTIEGGSFVSPKWVPQMANSSDILEHILTRNISSPSQTSYSFLAPNIKGLQNAQALLGKYPGAFASQLQPSTDESKPAIEVAVFAAATESFSKKNLNCDIATSLERFRDVIRDAKGAGLRVRAYVSVVLGCPFEGYNVDPHKVAEISTELLESGADEVSLGDTTGMGTAPRTKELLNCMRAAGIRNEDIAMHFHDTYGQALVNTAVSLEHGIRTFDSSVGGLGGCPYSPGATGNVSTENMIYFIESLGMDTGIDLDAMSDIGAWITGELGKANDSTVGQRPPKSERANCEVTTDLIGATCDPAYRVSGLHQRRSKLQCCAFDDTDCTDLPTSSSYVRRLATSPFIRPPTPFLIDALDPKRIVFYSGAVSLKSEAMSDPREPSYSIVPRIRYNTVGGVNGPLVILENVKFPRYNEIVSLTLPDGTNRQGQVLEARGDRAVVQVFEGTSGIDVQKTKVEFTGQSLKLGVSEDMLGRIFDGSGRAIDKGPKVLAEDYLDINGSPINPFSREYPEEMISTGISAIDTMNSIARGQKIPIFSSSGLPHNEIAAQICRQASLVQKQGITNKGVHDGHEENFSIVFGAMGVNLETARFFTRDFEENGSLERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVSGRNGSITQVPILTMPNEDITHPIPDLTGYITEGQIFVDRGLYNRGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSAEDKLSLEFLEKFERQFINQGQYEARTIYESLDLAWSLLRLYPKELLNRIPGKILNEFYQRAAKEAKDKGKQRAQVQQNEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3X4</accession>
    <name>A0A1B7Y3X4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155216.1">
        <property type="nucleotide sequence ID" value="XM_018305792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3X4"/>
    <dbReference type="GeneID" id="28869899"/>
    <dbReference type="KEGG" id="chig:CH63R_10818"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10818"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013311915" evidence="1">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="147" mass="15565" checksum="B1D7368C1D948631" modified="2016-11-02" version="1">MKAAVILSLVSFALGSVLEKRECSGNNCNRQVTGTREGLLPLTSRKADCSSFLQATVTPSPTTVTITVTAAPARLRRDGQIANRQVTELPTAIPAYASSCDDAAEYSSACSCWGITAVTSTAPRPTVTVTTTVDYCEASRQTWGWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4J0</accession>
    <name>A0A1B7Y4J0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_08473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155470.1">
        <property type="nucleotide sequence ID" value="XM_018303447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4J0"/>
    <dbReference type="GeneID" id="28867554"/>
    <dbReference type="KEGG" id="chig:CH63R_08473"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08473"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF86">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="69"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="775" mass="85627" checksum="CE795D40969422E3" modified="2016-11-02" version="1">MADDGPDPGWTTVHLKSQTHPDRLPPAHRELYEKSKIREWEMSSGHWSGVGKHPDDFVEAKKIHSKIIAPKDNDLGMGTFGRVERVTHRTVRLARKWIKPQRNQTFHTLRREALAMERLDHDHIVKLIGTYTFKQRELYLLIWPVAVCNLDELLTDLADLRSGQGDRGDILKRLEDLDISDPTLVECGRRHGPAEANNSSRCPLDFLQRIMGCVAQAVAHCHASKVRHLDLKPSNILLNPNKVYLADFGIARDFHNQDNTATMGLHGTPKWRPPEAYIPEEYSTQCADIYCLGLIYLNIATLVYHGDLEKFHSVVGDLAPRSRAEKLEAHQQNLALHALATQDFHDAKHPTVAPRHILGLTARMVSSDPKSRPRADEVDQELVDLGGIEQVYHNSCCRKSTRHVVKRVDERLSAMASENARLKPENERLQREIKALRAMDETYRLRIENQEKKHARDTDLLTRQRDEERQKRRKLEERVSELMEHARKRVRTGLPRADAVVDARSIPVAPIAPSVHGLGITSRPRTHPSSQPAIRPPPSTTNAPCSAVPRPKPPTRGSSGPHKAWVTPNLAVMSGASRSDPARRSSDTPSPNLQSSGTLPTRGSNSRLPVLAKIPATPRSSTPHLARDPGSADSTQASMSSSLFSRLSFETATEEALTPPAASPTLKQAGFDIVVREMPDASPSDEPSTPARSVPPSVSSALSSPRTTKAELASVAGSEVSRDGGVQAKQPPSLQPGKSWAAVAGESHGLARMVGPPLQISHAPVSPGRSRKRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y532</accession>
    <name>A0A1B7Y532_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase family M20/M25/M40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_08619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155616.1">
        <property type="nucleotide sequence ID" value="XM_018303593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y532"/>
    <dbReference type="GeneID" id="28867700"/>
    <dbReference type="KEGG" id="chig:CH63R_08619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08619"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="173"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="417" mass="45854" checksum="7721969F3B3DD17E" modified="2016-11-02" version="1">MLPVLTPSQMSEWVAAKMRAVGIDVTLKPLGKQTGTDLELPPLVLGRYGNDPQKPTVLVYCHYDVQPASLEDGWKHEPFVMTVEDNGRLCGRGTSDDKGPLIGWINMIEAFQEVGVDVPANLVFCFEGMEENGSFGLREALEEEADKYFADVDVVCIADVVWVSDEQLSIPQGLRGIIFYLVTITGAKQDAHSGGFGGQISEPMIDMVNIMASLVDSNGKILIPGIYDNVQPVTEKEYESYKELNISEDSLYGGTGGRSLHDNQADALIARWKKPSLSLHRIENALPGAGAVTSIPAKLVGKFSIRTVPFMKAEEIDVIVRKHIQDRFASLGSKNDIEIEAYPSDWFYEDAGHWNYEAAIRATRNVWGVDPAMTCEGGSIPIALDFKKILKKNVLLLPVGRPTDGQHSTNEKLDKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y591</accession>
    <name>A0A1B7Y591_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155683.1">
        <property type="nucleotide sequence ID" value="XM_018303660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y591"/>
    <dbReference type="GeneID" id="28867767"/>
    <dbReference type="KEGG" id="chig:CH63R_08686"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08686"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="509"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="955" mass="102707" checksum="1BD54A8168E4F4E5" modified="2016-11-02" version="1">MNNRHLPAGQAMPGVGGAGGVDMGGGPGGGNRRRMQQQPTYAQYQQQQYQQQHMPMYPNYMNPYAAAPYYHQLPHQYQNGGMPSGYMHYQQQQPYVRSPQAMPQYVPMAGVSVPQPYTQPPQPSPALSTPYQPPPMPTAIPVQSPPPPPPPQPIEPTPEPSVVAPSVVASSVVSSSVVTPFAEPFHPSVPAAPIPQSPELPKQNKEFRAPPKLPWTPPDQAPFPRRAPKSRRRRRLMSANAQDLTLPVEQHEGALESNASASQLPAEASATEVRDTTPGSAVKAQSKKTAFWNSKDTDSESATLQADSLTSETPKESDRSATSVSNAGSPKANAPASDRAAPQTPKESARPTTSSSNVSASRPTVPIIPVVPVLPRSSPKETKPASISKSAEDPKQPATQETKSAEVAETTDATGAEQKVGDQPAAPVKAAPKTWSGLFSAAAAAASKSQPSADDPVAPAATNGAATNGDGAVNGGASSFSAGNTNTLAAAIQDFRVSNPAKVQFIEPRGLINTGNMCYMNSVLQVLLFCAPFYNFLDQVSKRAVHKFKSDTPVIDAMIMFMREFRVIDATDSVEKLRRKLKSEQLEQYGESFIPEFVYKAIQPLPAFASMRRGHQQDAQEFLGLILNAIDEECAQVMSAGGLANGSAETRPTSSAASAVESTDGAEGWFEVGSRQRAVETRSSGASSTTPITRLFSGQYRSELRRPGVKDSVTTEPFQSLQLDIGAPYIHNVVDAIKGLTVPERLQGDAAPMTKQTLIETLPPILILHLKRFKFDTEGTTKIGKKVGYPLDLQLPVEVLSKRRRNALVAEGAPMPKYRLIGVVYHHGKQANGGHYTVDVRRQDDNEWIRLDDTVIRRVRSEDVAEAGAEEEVKETGRSGPASRDASANRFGAMADEDEGDGWKEVTTSTRGGDKSGEKKWSAVANGNGLAPKGKSAKDNIKDNKVAYLLFYQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5Q1</accession>
    <name>A0A1B7Y5Q1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kelch-like protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_08902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155899.1">
        <property type="nucleotide sequence ID" value="XM_018303876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5Q1"/>
    <dbReference type="GeneID" id="28867983"/>
    <dbReference type="KEGG" id="chig:CH63R_08902"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08902"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="280" mass="31678" checksum="81B8C6AF7D698797" modified="2016-11-02" version="1">MTDMLDRGAQRPEEVSDVDSLLRQPQTIIWLKTAEQSFAIHKSLLVESSKYFQRCLDGPFTESRTNTIDLDDDSDDSEGNVSISPLTLGTYVKLCYFTRLTAQRVKRSRRNAADHTEDSYEVSPFTLKPCDMHTPHDLTELVDMWSLCDRFHDDLLLGKVSTAIRETLNVGAKKLGEAHCAEWWVFNFANGYVALEGLHRRDDELEGLLEKLKELFVRNCSPASWERLACQLPSDFVVAASIAFQAKMATLMTNEAAIARVNGASLCYECKSRVQMALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y684</accession>
    <name>A0A1B7Y684_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156077.1">
        <property type="nucleotide sequence ID" value="XM_018304054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y684"/>
    <dbReference type="GeneID" id="28868161"/>
    <dbReference type="KEGG" id="chig:CH63R_09080"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09080"/>
    <dbReference type="OrthoDB" id="4160219at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="133"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="664" mass="70268" checksum="0A5971338A06C8E5" modified="2016-11-02" version="1">MITKLPNSNAVIERVPGLNGNDIGPRRKVRDKGILAGPSSMAHERTPHLRNRQHVADNESKRADEEASFADATETTTLLNSETSSRTLRNGSSAGSRRDRGSSPDKGDGEDDQDDDDDEGPKQSISATRAGVLMLSTWVLIFLQGPQSTERPTPRPASNTSGMTMTQSVVAEDLEAYADAMWFTSSYLISMASLAPLFGRLATIFSPRSLVLPLGCFFAAGGVVTSQAPSFWVFIAGRILTGMGGAGIMTLSVILVLELVGKRRRGVFVGLVNAGFTIGLSFGAVVYGALLSVIGWRALFAVQTPLGLLAGLGAFWSIPKSFSSDHETKGKSALQKLARIDYAGAVTLVLTIVLFLYGLSGEIQTRPLVLSALSLLLFVLIEFRLAADPIIPLSVLSSRGVLLSCTAQLLFMSIRWTLLYYAPIFVLAVRGYAPAVAGSILIPTNVGFGSGGLIVGWLHVRRNGAFWSPSVVSLTCFAATMFGLSFVGTADSPVWALILAVVLNGLATGATLNYTLAHLLHLSRPEEHFVSTSLLGTFRGFGGSFGTAIGGGVFYRILRSGLVAGFTELDGGRLSEERRELVTRLIGSPALVFNGGLSPAEHAIAVERYAGASRGTWRAAAALAVVAIVIQASTGWRGPTGGKEVDDETEARAALMENEGAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8U8</accession>
    <name>A0A1B7Y8U8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_07268</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157021.1">
        <property type="nucleotide sequence ID" value="XM_018302243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8U8"/>
    <dbReference type="GeneID" id="28866350"/>
    <dbReference type="KEGG" id="chig:CH63R_07268"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07268"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR08503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="267" mass="29312" checksum="CBE62B962B280C3F" modified="2016-11-02" version="1">MKDAPCWTNFIVGSSNIEYRDVIATAITNNGSIIPKNTDFFDSLDVQDVKIERVWVNIDDDCFSPKSNNTNLYVNTMYCNGTHGQSIGSLGQYPGEMSFVKDVHIENVWMLNGDYSGARIKTWAGPNVGYGFVDNITYKNFWVARMDYGIILDSCYFNINETTCEQHPSGMNVSNVLFENFTGYTSGIYGNAVAKLTCSTNPDAVCHNIKFKNFNVTSPCGGEPVVICDGIDGGLDAPCVSIDSDEAKAALAAKCQTPLAPINEHPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAZ2</accession>
    <name>A0A1B7YAZ2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157763.1">
        <property type="nucleotide sequence ID" value="XM_018302985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAZ2"/>
    <dbReference type="GeneID" id="28867092"/>
    <dbReference type="KEGG" id="chig:CH63R_08011"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08011"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41170" checksum="5816930CF4F67E3B" modified="2016-11-02" version="1">MPPLPSPPPHQIISRTLRNAGCLAPRPPWAKKLPPPHSRLNSTSQAVSHGRARPPTTCPTTPARRGFCASGHHRDSDFAAAADMTPPSAGGGLPRSNSCRTHARARLQETLTADLLERLRRFWFKHLKTDDAYILPQKSQMGRWFFSDADFDQVCVRKYRPVLEAMRSARTTSKDLLSILRPSTPLQWLGLVLLLDQVPRNVYRGPESSVVFHFFDPVAREVAQHAIEAGAPTHHRVRYRVAYRMWFYLPLMHSEDLALHDAAVGHYRRMRDDFEELMAGDGAAGPDDQRKCWGVLAARREAARDLLETNYDFEMKHRDIIVQFGRYPHRNAAMGRPSTAEERDYLDNGGETFNNSSSGGSGGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBS5</accession>
    <name>A0A1B7YBS5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158006.1">
        <property type="nucleotide sequence ID" value="XM_018303228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBS5"/>
    <dbReference type="GeneID" id="28867335"/>
    <dbReference type="KEGG" id="chig:CH63R_08254"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08254"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="381" mass="42112" checksum="2DD716E128AB2D26" modified="2016-11-02" version="1">MVNIVELLGKADNLSDPEPALNSRSAVLGMVISFLLTSLLLSAATCSADPIPPATNYGLGKHFISLGIMGIQDFIRAFYICNGAYPMATALIKLALLFQYLRMFEPATKSRYVTLFFIVFTAAWGVAYSFLAWVPCIPVSAFWDFFSVTEARWAFGSRDPEVFARSFESHVGINVALDLIVFAIPIPLFLRAGLLTKTRWSLFGLFIMGVLVNILGIFRLIGIFHSRAGTYPTLDPSWYGCVPIVLAAVEVNLATICASLPVFWPTLQKNLGQIFITKEVEITSEIRRFSTLEDGDPAAAELGDFSPRRPSKALGSNPNARWYTDTLSLARSTKTEVESRGLATKASEKSLFSEGLKRIQEDRESKDHLVSSPSRSRLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBZ3</accession>
    <name>A0A1B7YBZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157991.1">
        <property type="nucleotide sequence ID" value="XM_018303213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBZ3"/>
    <dbReference type="GeneID" id="28867320"/>
    <dbReference type="KEGG" id="chig:CH63R_08239"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08239"/>
    <dbReference type="OrthoDB" id="4524805at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601511" evidence="3">
        <location>
            <begin position="39"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="578" mass="62648" checksum="AE49EEF7F45BBC52" modified="2016-11-02" version="1">MKLVQALLNSRPRLRFRFLSFALFSFLFLVCSPATSHAAPSVRETRNSNHNNNPLNIDWDPAPSPEDGPPASAGALRDPAYIPYQVGAIVGSYGVSLVLVAVFLLILSKRRREALSAANQEIEVDFDELEPKSPPPKLTLQVPSSLRSIPRSPVRNFSYPSADEYYTPEYPTPQTPYVAPTPTSTLHAPGVDFTVDQRVVAQDKKMAQSQLEEMYKYVMEQEEAKAQGIKLDEPPRALSSHPPQLQTPSHASFSRSSVRKEKHKPGNLNLVEGKPEGKPGGKLEGNSEAVPGEKPEKKQSRASSIFAALRSPKKTKEVRAVNISSPIMTPMTGTFPRHESQELSAIQPRQYAPPPPPSLPSHHHMSYGGVHHNNGQMSPVSPEHSPESTQSIDERIGGHIPIGIDHVRHPSAALSERDPNSAVSDRSTAPLIGLPSTPKPGARFSTSTLPASPRPGASFQIPPPPGAGGGGGYRSKAPSAVRTGGALPLRAYEPALNSPSQSSQTTKQTVFTRTGPLSPSGARTPATGMAVPYSPYQPFTPCVPMTPSLVTKADRKRMKKLEPKTPTREMVRSEEDIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCQ1</accession>
    <name>A0A1B7YCQ1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_05528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158353.1">
        <property type="nucleotide sequence ID" value="XM_018300503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCQ1"/>
    <dbReference type="GeneID" id="28864610"/>
    <dbReference type="KEGG" id="chig:CH63R_05528"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05528"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="43202" checksum="9ABC24A66D65FF08" modified="2016-11-02" version="1">MAPTPPAASPSAATTSSTDSKMEVWKETLYDHFQKAGDEDQLFTQYDILDFDVIPNRDTVTLLKVLQSLTNDRLLIAVSSQTGLAWRWRSVEDAEKYKLCSTDEQRMVYGAIDEAGGDGIWSKSIQNRLNMHDSVLKTALKQLQGKGLIAPFKNVEHPNKRMFIKASMRPSERATGGPWFTDSALDEAFIEELQRVIFDYIKKKSTYLSTGSSGTRTAVPKKGVLKGGLDAKGKKRGASEMSGVDDEAGAKSAVLAVQPPKKVPVNLPLPAGYKEYPTVREIARFISQSGITSDTILGEEDMQKLIDVLVFDGLIEPIRISGHLGYRVTRAPRQSTTNWAARQGGGPDEGGPEPFVNGYTEAPCGRCPVFDLCEEGGPVSASNCVYFNRWLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCY2</accession>
    <name>A0A1B7YCY2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_05400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158225.1">
        <property type="nucleotide sequence ID" value="XM_018300375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCY2"/>
    <dbReference type="GeneID" id="28864482"/>
    <dbReference type="KEGG" id="chig:CH63R_05400"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05400"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="615" mass="67533" checksum="D3DE5FE1278608AE" modified="2016-11-02" version="1">MSNAGGLNDDVLAKAHVASATVQGTGAETRGSFDVTAAAAPAVVDDNYYDSKSDDDYEDKPTEEELNTLRRVSGPIHWGIYTIAFAELCERFSYYGSSVLYTNFVMRPLPPGSKTGATYGADIPAGALGMGQKASQGVSLVNQFWAYLVPLFGGWLADAKLGRYKVIHIAIAVSTLAHIILVISAAPGVLSQGKVAFAPFFIGLFTLCCGTGLFKANISPLLAEQNKDTRMRVEVQKGERVIVDPSVTNTRIFLWFYFAINTGAVGGQISMVFVEKYHSFWLAFLLPTILFLICPFVLYFNKKNYHLTPPTGSVLEKFFRMSSFAAKRSGGYTKLNWENAKPSNIPVAERPGWLTYDDAWVDEVRRGLMACKVFLFLPIFFLAYNQMTNNLTSQAGSMVLGGAPNDVIQNLNPLSIIIMIPILDHLIYPGFRKMGFNFTPIKRMTTGFFFAASAMVAAAVMQHYIYQMSPCGDHATICEEGPAQINVWAQCLPYIFVGLAEIFTNVTSYEYAFSKAPENMKSLVMSVNLAMSAVSAAIGQAFTPLSDDPLLVWNYACVAIIAFIGGVAFWFCFKHLDHEEDELNQLKKTKFLGTNQPNAVARDDAAAQAHVSEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YD07</accession>
    <name>A0A1B7YD07_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CH63R_05430</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158255.1">
        <property type="nucleotide sequence ID" value="XM_018300405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YD07"/>
    <dbReference type="GeneID" id="28864512"/>
    <dbReference type="KEGG" id="chig:CH63R_05430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05430"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601546" evidence="17">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="479" mass="53350" checksum="62910F2DB3AB713C" modified="2016-11-02" version="1">MTRTLGLLGRHPLLSLVLLLSWLAAAVEAQGVAELLSQIPSCALPCLTQGLADGNCSLTSAVTAADCLCLNIPLQSDLSTCVQLNCHFEDQARAASLETSLCAAYPKESRSHEVKTIAIVLSVITFPVVALRCISRWMITRRLWWDDWTAVFATVLLAGLAGIEIASADLGFGTHYWNVELAAGTKLIQLFYVVQQLYILIQVFAKISILLFFSRIFPARWFQLTVRYFITFLLIHGLVFLLVIVFQCTPISSTWDRSNPDRKCLNVTAIGYAGAVLSIVEDLVILVLPIPELVKLQLNIRKKIALGFMFSLGSFACITTMVRLKYLVMFSSTFDTTWDNVDIVIWSIVEEFCAILCASLPALRPLLQKVPQLFTSKKETTKETRSTAQSRRSILHIGKDKFHELPETPVSGVDDDDDDDEDQPPALIDIADQMAAQADGKRPVVFAKDKETTVNWRADVELQNVKEGKRWQKNVNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE08</accession>
    <name>A0A1B7YE08_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158631.1">
        <property type="nucleotide sequence ID" value="XM_018300781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE08"/>
    <dbReference type="GeneID" id="28864888"/>
    <dbReference type="KEGG" id="chig:CH63R_05806"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05806"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="178"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134909" checksum="8F4A3E98352D4AE0" modified="2016-11-02" version="1">MVVDIAAADNSTAEIFFHPLYLFLDRLLFSHARPPLRGLANGLLLRFSPILPLSLPSLFPTLELDAAMLWTLFMKIILISSLVAWWLKRPNSRFQKFVLLAATLAAFWVVAPLYASLCLAWSVHYTREGIRYWSLDELLVRHASMLVTLAAVVWLLHRAWQTLWKPTTDLISILGVDVPEAPDVSLAGIRPDAATLNWTRPTHNRPVQKFLIQVNGVNVGESRQEETAITVTGLRPNHCYNIRVIAVGPNNFQAGSQVIRLRTYRSDGRPELGNSRLPDSFQEQDPKSGQFPCVEDNAGRNQVPTIEAAPSLESGSAAARDGPSSQRRNTVNRRHSPSIASQEQPSIKDFASDHPEASLKDLADTLERTRKEIDETAALHASEESEFKQLEERLKKEKEEKKKMQKEKDDNTAQLRQKVKATYEQMRQATKDKARKENLLKERQDKRKKISDNVDKWTTEIENMRKTRKGFASEKESLEQDRDLKVKHLDEDNSALQEEYSQLEAEYKEKKEQLKELEDARRKLPGGEEDDTWREDDRKMKRDFEMKRRELQSQLIMENRKAQQLEGHIHVLHAQVYAQNQQSLQLYNQANSSGVDFEQNASAQVKRRSRTGNTLSNAVISSPTGPFPASDSPFEPPTSFSNRSGFSHFLDISGGDGFGADQFSDTDLRALPGNAPLSPTAAALLPSGILGDDESASPDSFSRRSPFVPEDEYDAQSPQSSKPSNSAQSSPPGSSHKTAFPPFPSFPKDEGDHASLNDVTSSPSGQPPPAAHRFTSLLSSFQRGKGAKAVDEGGPMLGTLKHGQSQSFPRHTDDPDATIRRRTSFSSVGRDRNSAGPDTIESSASNLGRSMFSSARRLMLWNVPFADRDPSSPRPASMASADLPRPSTDSGSIWNHPGDRNRLWSPDGPWPSRTPSRRPSLHGSPAALKTTLASADDEILDHEALNDPQVSPSQVGVIGSRPPASKQNSDSKSLLSQRLNPAAPTFSIGGIGGLFRSKDKESDSGKDKDKSKSKDRAKDRAKDKEAKEKGKTREFSTPSLDLPQGYDASPTDSRKSRDAFSVHTQASVTESRESLTLDRAVSSTLSDSNVKDQENAYRKLFRKGSSSKFSLSSRLSKDSGLFKKGPGSTTNSDKNLSADRSSFGDIDDYGEEGLLGRSYESVTSSPSLGPSKSKETKESRMTNWSSKFSMKKKGNKESVDLHRATLEADDEEDKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YE81</accession>
    <name>A0A1B7YE81_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158856.1">
        <property type="nucleotide sequence ID" value="XM_018301006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YE81"/>
    <dbReference type="GeneID" id="28865113"/>
    <dbReference type="KEGG" id="chig:CH63R_06031"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06031"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29821" checksum="3E77BA428F245908" modified="2016-11-02" version="1">MEILNQVIDDKRGAYRLRAGQRIYYLFIATGTFEEDTMCRPYLLIPSLPDLPDSPWTTATIVRGADGSPFISAISTDPLSEIQTVWHERRIDVLSLKRTRRLRSWTHEVQYDGGTAVAKIACFEWDLRRIERETAAYYKLTQHRIQHRDEPPIAPEFLGHLTENGRVMGFLLEKIDGERACRSDLPDCETLVRRIHGLGMIHGDVNRYNFVVDRAGTGGVRLVDFEHFEDFSEETAMEELLALPAELAEDTGRGATAKVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEA3</accession>
    <name>A0A1B7YEA3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_06054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158879.1">
        <property type="nucleotide sequence ID" value="XM_018301029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEA3"/>
    <dbReference type="GeneID" id="28865136"/>
    <dbReference type="KEGG" id="chig:CH63R_06054"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06054"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000138">
        <property type="entry name" value="Putative alpha-glucosidase AgdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="403"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="11">
        <location>
            <begin position="847"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117690" checksum="A0CE127188ED1B70" modified="2016-11-02" version="1">MAPNDWFNRREWEGIRGDNATAFWTTSIWWIATSIVLVQCLWMLYFRRSLKQQFEKGEKRRSMFARAPLLLPAAAVMALCTMARVADLGRPSAPQYLASTSIASSTSQFTVPASANEGALLIPNIEDPESTDPQSVCPGYTASHIQTTSYGFTADLDLAGSACNVYGNDVEALSLVVEYLATDRLHVQVLPRYIGTRNSTWFILPGELIPKPAADGKASSDGSNSDLEFKWANEPTFGFNVSRKSTGDVLFTTAGTKLVFEDQFFEFASPLPKNYNLYGLGEVIHGFKLNNNLTRTLYAADVGDPIDGNIYGSHPVYLDTRYYQVNSDTKEAVYVANATDKNAEYTSYTHGVFLRNSHAQEVLLRESNITWRGLGGTIDLYFYAGPTADAVMKSYQKTTVGLPAMQQYWTFGFHQCRWGYTSWDNLQEVTDDFAKFKIPLETIWADIDYMNQYRDFENDANSWSYEDAARVLGSLHKNGQHFVPIVDSAIYSPNSENASDAYPTYDRGADADAFMLNPDGSLYIGAVWPGYTVFPDWIGAVLNGSRTFEWWKTELVTWFDKVAFDGIWIDMSEVSSFCVGSCGSDNLTLNPAHPPFLLPGEPGNEVLEYPEGFDRTNGTEAASVSSLSSSLAAARTATAAIPSSSLYTTTSYLRTTPTPGVRNVNYPPYVINNIQGDLAVHAVSPNATHHGGTQEYDFHNLFGHQILNATYQALLSVLPGKRPFIIGRSTFAGSGKWAGHWGGDNASLWAYMFFSIPQALAFSIFGVPMFGVDTCGFSGNTDMELCARWMQLSAFFPFYRNHNVIGAIPQEPYRWAAVADASRAAMAIRYALLPYVYTAFYRAHKQGDTVMKALAWEFADEPWLAGADRQFLLGPAVMVTPCLEQGASTVDGVFPGVGQGTVWYDWYNQSAITGVSTGQNVTIDAPLGHIPVYVRGGYVIPTQEPGLTTAESRSNPWGLLVALDDKGTAKGSLYVDDGESVEQEATLTVELSASENSLKATPSGEFRDSNSLGTVTVMGVQGDVSAVTLDGRDLDSASWTFNSTTRALHIHGLKSRTSEGAWSSARELVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEW6</accession>
    <name>A0A1B7YEW6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_06271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159096.1">
        <property type="nucleotide sequence ID" value="XM_018301246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEW6"/>
    <dbReference type="GeneID" id="28865353"/>
    <dbReference type="KEGG" id="chig:CH63R_06271"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06271"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04081">
        <property type="entry name" value="CBM35_galactosidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601593" description="Alpha-galactosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="9">
        <location>
            <begin position="325"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR10579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="557" mass="59614" checksum="E6C5D3D7725DFC33" modified="2016-11-02" version="1">MASSSSSVAFALLTALAGRASARTHKTPTPQMGWNSYNYYNCYPNETIIKQNAHALVDTGLAEAGYTTVTTDCGWPAKDRAADGQLVWNPELFPSGGGKELGDYIHNLGLKYGVYSGGGYFQCGSTDQPASLNHELTDAKSFAAWGADSLKYDNCYAVKPDVMVDFVHPDAVSPDRFETMADALNTTDRDILYQVCQWGTGTDLGIWAPKLGGNSWRISNDIYNGWRSIWRIANQVVPFYKHTGPGAFPDMDMLLIGLNALSIEEEKFHMGMWAINKSPLTLGAPAIPGLVPDSAHAILTNREVIALNQDPLARQTELVRRYTEEEWDVWAGELSGSRLVVGLANWRNDSQSVRVDLAAVLGVASAAAARDVWAAADLGPVSGTYETTLAGHELKLLVLSDIVAEPKPVHASAGYYTAATDAALSGSAVKVACADGQCLPSKAKVGNIGSGAAVRFEGVAATSEGAKLLGVDFINYDVALDSAWGFGSNTRNLTVSVNGGAAKRWAFPISGGNWFETGRLLVEVDGFRGNASNTVEFKSVGSDWAPDLVGFEVFERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFK4</accession>
    <name>A0A1B7YFK4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_06531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159356.1">
        <property type="nucleotide sequence ID" value="XM_018301506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFK4"/>
    <dbReference type="GeneID" id="28865613"/>
    <dbReference type="KEGG" id="chig:CH63R_06531"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06531"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="578" mass="60587" checksum="1A6C9FA5640C243A" modified="2016-11-02" version="1">MGSAVDEEQKVTEPQPLVPGGDADRDSAAQSDGDSGESLSGFRLISCLSALLMCNFVVSLDMTILATAIPRIVEEFSSLEDIGWYGSSFFLTISAFSQFWGKAYTYFSLKWVLMTAIVIFEVGSLICGVAKNSPTLIIGRAITGAGGAGISNGCYTIIGVVAKPEKRPAYTGILAAMYGFAAVIGPLIGGAFTTNTLADLLGPRAGVPSFYLNLPIGGIAAFILLFVARLPSSKMVKTTTKEALLNMDLVGAGLIMAAFVCYLLPLQQGGTTKSWRSPTVIGLLVGFVLLLALFTVHQLWLGERAMMVPRLMKQRRIISLALFNLFMAGSFFTFVYYLPIYFQVIGHYSALGSAVQNLPLILGSTVFGIVAGVLMVPVGRFHIFLISGAALVAVGGGLTCTLQVGLDTGKHVGYQLLVGVGAGLCLQVPVMVGQAFSLPADVASTTAILLFFQTMGGTIVISAAQSIFTNGLVNALNAAGFHNTSLVLSSDTAHLSSVLTADEMAVVLPAYLTGLRNAWAMATACGGAALLSSAIAKFENIKNVTPQQKDAVAETKEGNKHSGSSTPDESFGEKGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFR3</accession>
    <name>A0A1B7YFR3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159413.1">
        <property type="nucleotide sequence ID" value="XM_018301563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFR3"/>
    <dbReference type="GeneID" id="28865670"/>
    <dbReference type="KEGG" id="chig:CH63R_06588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06588"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="392" mass="42658" checksum="90CD207E42DD7AE8" modified="2016-11-02" version="1">MPRTLQPEPTANADMPEALETRPPSGRIEEEARAKSPKNKPPAQAQNNHGRRSRRRESRRRRKQQKREADAQQLLQNVGRVAPIQPSDAERLTDVDVQPGTELSRSTCHDGMDDDETVSILGGLADLFSTDATEGTSANTAPAPDVTMIDHLDVGLAGPLGIDLGIAASTSPFGHEAFPNEPSSDQNGGCGLSITSVWGFAPVISYSSIAGPPPRMVAIHSADGWNEMLYGDFAPLGRLNICPYFQFTDLLVRELVADPARTAKLTQITVGNSDCRNFLTDNGLEDLACGCPALEYLTIHGAVKISDRGFQAVIDKCPSIRRIALCGMDYEPNNVCGSALVKLMEQPFIALYLEGIVLRNTAVHPLTVRRLREHRNQLKISAGPWDMEPGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI43</accession>
    <name>A0A1B7YI43_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160061.1">
        <property type="nucleotide sequence ID" value="XM_018298815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI43"/>
    <dbReference type="GeneID" id="28862922"/>
    <dbReference type="KEGG" id="chig:CH63R_03840"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03840"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF3">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="518" mass="57420" checksum="296A8049B072CA13" modified="2016-11-02" version="1">MGVNGALSNSRIKEILMRHGMSPKTSQECALNELRGWSTSAVESVLSKIKRPCIGHCPLNYTSPDPDETSIGRRLGSWLPSAWVRPPLGLVRQAVDERKALCVNRRFQWSLCGDGYFAVSHVWGEGIRADPKGRGLAHQHLTRVFDALASTGAEWIWLDVLAVPNADPEGLNLSPEEKELQVKVINTLPQVYEGATAVIVFDALVLQMHGASSADVAVGLVCGAWISRVWTYQEIRLAKKALIVTADRIYTWDEIVKNLWQLVEDDDDGSRQGGPPRLSRFYSLYLSMAILQYINETGLSLTDISFASATRQSTYEIDYARSLFALVDLPWDPAWKTSAPGMQAIYQHRRQDASRLVAMYGAKRLKVSPRWAPSRLAGLEGTVHGDMIWEERGLRGMWYRERIASFTELVLGKGRRAMRLFLSDRDCDLWCEVLVGADEEAETIDGFKKAVGDGRAFLFCKHQIADGVGLERGTASQALVVETLDGGQDGEVDVLFATALRAVQGESSGEQSSVLLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKP8</accession>
    <name>A0A1B7YKP8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161092.1">
        <property type="nucleotide sequence ID" value="XM_018299846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKP8"/>
    <dbReference type="GeneID" id="28863953"/>
    <dbReference type="KEGG" id="chig:CH63R_04871"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04871"/>
    <dbReference type="OrthoDB" id="5137852at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="59772" checksum="716AD8F91F3A3F6E" modified="2016-11-02" version="1">MAFPSEIVDLILCAYIVDRHFGRMQYDGSPNSWQDGSLDSWEDFTATSGRHTVGVWDGRHYYETKFYRKDVCDAESFISLLSCRLVSRQWDFSVCRLLQKHQWWNLHLDKNSTFQRAASCIEGEDSGSLKLIRNLCLDEMADLRTFSRIYSYDNEDVSRFEGQDMDDDDILLNSYVDQITAVDRRSTRTDFELHYDKGEELGLLRRLFDKLTNVERLRVEFPGAESENELQAQCYDMQGVEEVVATIQYGLRSPALHHLVDLSLSLPSTWHVGQLGSALSQDARDRLCHLQLVIVDETGPSGSLSYTLGEDGNDNGDMTSVLESSYAPSNVQVAYPNREHQAELWRFVASCRNLESLAIEATHYLQLEQLDWSPPLGSRGLKNILMRRMWASASSIRRLLSTSSGSKTRPAVRRVVLDDVKIYADGGNWEVVFNHLRTNCPDLELVRAEQLSYFSEHPRYAHNNRPWENFANVWTADNAEDNNDTSYLHMINKMMIQRSGSSGRGYPVFLDDWESEDEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKQ1</accession>
    <name>A0A1B7YKQ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161049.1">
        <property type="nucleotide sequence ID" value="XM_018299803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKQ1"/>
    <dbReference type="GeneID" id="28863910"/>
    <dbReference type="KEGG" id="chig:CH63R_04828"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04828"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="90" mass="9801" checksum="AB1A2C325EBEC683" modified="2016-11-02" version="1">MRYYHMQTATHSLGFQRPTTISFHLVQQQARPEANIPSLINTPALPRGMPPSTGLASIYLSNLGLSEDSFDSRLASLSGQSICFGVCYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YL62</accession>
    <name>A0A1B7YL62_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161211.1">
        <property type="nucleotide sequence ID" value="XM_018299965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YL62"/>
    <dbReference type="GeneID" id="28864072"/>
    <dbReference type="KEGG" id="chig:CH63R_04990"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04990"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="102" mass="11537" checksum="AA5F67C12B44569F" modified="2016-11-02" version="1">MPVSEQLVNRRQNSRTHKRLISHLWADWSTSATSATAAAAGLWKVVREVERVDDLTLFLRRWLTPELTLHSERGPPPFCLPSLIPRRRGRSATPSIASNVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMG1</accession>
    <name>A0A1B7YMG1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_01963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161754.1">
        <property type="nucleotide sequence ID" value="XM_018296938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMG1"/>
    <dbReference type="GeneID" id="28861045"/>
    <dbReference type="KEGG" id="chig:CH63R_01963"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01963"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="276" mass="30992" checksum="A31F445727E976BA" modified="2016-11-02" version="1">MSGPAVAEPPLAHFQAQLHPNDSLFDDQGYFLDNDFDSEIHRHLSIFGWKKAFRFGIHQQANLERLQELGFLVALPVGFNLRIHTPPGYIRYRLIAIFATARRAVEQQLKNERRSQIPVIMVQLTEVEDEHFQSGQAGPIEDDADFTDTDSEISADSDYDPRDESFAERIYALKDIVPPTTRGWISNKIDFGVSAVQNTWYYSSRTVWVVCATALMIGVPLATCWAEDQQLEGMEREFRMREAGGDALLTAGESQEGSTADQIGLALDRAEAKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YML0</accession>
    <name>A0A1B7YML0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pectinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CH63R_01880</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161671.1">
        <property type="nucleotide sequence ID" value="XM_018296855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YML0"/>
    <dbReference type="GeneID" id="28860962"/>
    <dbReference type="KEGG" id="chig:CH63R_01880"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01880"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF9">
        <property type="entry name" value="ENDOPOLYGALACTURONASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601811" description="endo-polygalacturonase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OBR13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="377" mass="38626" checksum="A783694996BCD938" modified="2016-11-02" version="1">MAKLFAPVVAALLPAVLVTAAPTAVSNATGNGCTVTEYADIANAVATCTDITLSNIAAPANSPIDLQKLQQGATVTFDGTTTFATTVDKKFDPIIISGTDITVTGAPGHVIEGNGAAYWDGLGSNGGGDKPNHFVVVKKTTNAKITNLNIKNWPVHCFSMTGNQGLTVSGINLDNSAGDEPNAQSGSKAAAHNSDGFDISSSSNVLLENIRVHNQDDCVAVTSGTNITVNNLYCYGGHGLSIGSIGGKSDNTVDGVVFSNSEIIKSSNGCRIKSNSGTTGEVSNVTYQNITLTDIDTYGIDVQQDYLNGGPTGEPTNGVKISGIRFIDVAGTATDHGYNYYILCGEGSCSDVTFENTKITGGGKGGSCNFPASGCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMM4</accession>
    <name>A0A1B7YMM4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_01884</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161675.1">
        <property type="nucleotide sequence ID" value="XM_018296859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMM4"/>
    <dbReference type="GeneID" id="28860966"/>
    <dbReference type="KEGG" id="chig:CH63R_01884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01884"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601812" evidence="9">
        <location>
            <begin position="21"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="165"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="590" mass="62049" checksum="95D84C412B184118" modified="2016-11-02" version="1">MALLSSAILALSLFGTITQAWPQLPTDDGDFTSLTTLPTIPYTTQDSIDVAPRGLSLPADEDAEAGMVMTLPVTSGPRRKRRTRSRRKILLDDMLDDDDLEAALPEAPPQRLKPPVSMRGLLPVDDDQVDVNGAFVTLPVIHSTKRGVFSRQVEAKLANRSDVAYYAQLNIGTPPQAVYAQLDTGSFELWVNPDCTVLAAADQRFCEAVGFYDSARSSTAVSMQTSKTLRYGIGAANITYVRDSLALAGSRSTMRQVQFGVATSSEDQFAGILGIGYGEGVNTRYKNLVDELAAQGVTRTRAFSLGLGSKDEQEGAIIFGGIDTSKFSGALARLPIVPAGQAPDGVARYWVTMNSLSLTPPSRRTRVYPNSRMPVFLDSGATLTLLPEGLANMIAADFGSPGVDANGFYPVSCTLVGLNGTVDFDFDGMKIRVPYKEMIRELRTTPPACYLGIVPSSDFTLLGDTFLRSAYAVFDLDTNAAYLAQYSNCGTRTMPISRPEDIAAIRGLCPDPAGAVAPPPATNGTTAPPASGSGLGSGLGSGPGAGSTLPTGPAPDMSGVPAAGTVSLASATNPSMLAVISTLVSAAMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP04</accession>
    <name>A0A1B7YP04_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162256.1">
        <property type="nucleotide sequence ID" value="XM_018297440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP04"/>
    <dbReference type="GeneID" id="28861547"/>
    <dbReference type="KEGG" id="chig:CH63R_02465"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02465"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="73" mass="7567" checksum="9CA1B8FE47670479" modified="2016-11-02" version="1">MYGRPDASYDAADDPLFLIDRPFSPFPVPIVCKSLINATAVGTLRLSAVEKSAGEVGKGIAPEHGSTSGIHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPA8</accession>
    <name>A0A1B7YPA8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_02444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162235.1">
        <property type="nucleotide sequence ID" value="XM_018297419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPA8"/>
    <dbReference type="GeneID" id="28861526"/>
    <dbReference type="KEGG" id="chig:CH63R_02444"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02444"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="949" mass="104810" checksum="38EB2B6B1FC24672" modified="2016-11-02" version="1">MASSITPAQAELIRRVAPPSRPVVNLLTSLAPDDIPIKLRCAICSKLAVNAFRLPCCEQAICETCQSSLPSSCPVCEHSPVSAEDCTPHKSLRTTIKVFLRTQEKKREEARSKDAKDSAPPAPVDAKPIVQQAAPSESPAVETPSQPAVVANAQFENTDSQAAQAADASTNGSANADADAAAAQNSTGEDDDDEIVIITGDENAAAARQNTDQQEGDAMENNGAEGDDADANGNANFNGMNGSNFSNMNFNGNGDFSQMQMMMAMQNGMGANSFGNFPMMGMGMDPMAMQNMYMNGGYGPQGMGMGGFGGGFGSGSNNWNGQQSWNFGQDNFNSANAAGMGSGDFGNYNSGFQSGYNQGNYGHQFNDYRRNNYGNRGRGRGRGFYGGGYGRGGYQQYGGYGDQGHMQQQQQFGHNTHGQGSDEGSRATANVDEFGRERKDDQDATSNAGGGNNDNNGEGGEGPKPVDEGGNEQGPRDASEHEKAENGSHMAQDSGDYAAYNGNGMPGGYGPSGFPNQNLGFAPAAPDVPINAPTGPKAMRQGLPNTSLHTLRARGYVIPDEGGRQTSVDGVQSPTVEHQRSRSNSSAPIKDQDKSRRRDASREREREPDVRSERDYAGRERDHSRSPSRSRDQSRERKSDRGDRHRTRRRRRSESRSVDDRDDEHRRRKHKSRKHTSYNDEDEVKSRSKDDGHEERSRSASPSDSKRSSHRSRRDRDEKRRDREKDKYRDEDYDDYHRKSSHRSHRDRDRDRDREYDRDRDRDRDRDRDRDRDRDRKDREREKDRKRDKHRDREHRHRSSRKHSAEPPTPVEKDFNPPTGPRGSTSGLEIRGAGSKPGRSSDRQDAGRRDSQASVNSKSAGGVPTKDAHALEREARDRERLLKETQRMAGLAGLAGVKRSRDDVSGGGGGGDDGKRSRRKGRRSEAISMDDEEERMRRMEAEREGHRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPF1</accession>
    <name>A0A1B7YPF1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_02661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162452.1">
        <property type="nucleotide sequence ID" value="XM_018297636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPF1"/>
    <dbReference type="GeneID" id="28861743"/>
    <dbReference type="KEGG" id="chig:CH63R_02661"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02661"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="56300" checksum="2F000F8635E2EC05" modified="2016-11-02" version="1">MSDENSSRSPISPVTTTSNISRKQTISSPGTTTSPVPSGHFKRTVVVDDTSQMRRRPPFGHIPTENSFAETGLGRRRSSTLSEYSFSEARDFLSPRHGDIPSTSSADEMSNWASIPLAFALLPAVGGLLFQNGSAVVTDVMLLGLSAVFLHWSVTQPWTIRALTHQPPRNWYHSAQAVRVRAEINTSAVIDDESETEQAVGSPSSATSTANGHTANGSIDDMPEVPTTPTSFVQGQVPKTMPRVKKEDALAELWVHEILALISCFMFPMLGAYLLHAIRAQLSRPSEGLVSNYNLTIFLLAAEVRPLSHLMKLVQCRTIQLQRDVHVNPYKDDGVTSDQVRVVMARLEMLESRQEPTQIKQNGNSDNSKIKQEASIARDVRNAIQPDLDALNRAVRRYEKKATVLAFQTESRFAAVDTRLNDAIALAAAAAKNSVARPGFMQWLVESVWAVITMPFFAVVALLVLPFKTLRGLLKRKKKSLPERTRSSRNGKAMGHSRIAADRPPSRVSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPG9</accession>
    <name>A0A1B7YPG9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH63R_02683</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162474.1">
        <property type="nucleotide sequence ID" value="XM_018297658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPG9"/>
    <dbReference type="GeneID" id="28861765"/>
    <dbReference type="KEGG" id="chig:CH63R_02683"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02683"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="639"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="878"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="914" mass="101253" checksum="D3322E65B44F0234" modified="2016-11-02" version="1">MACARLLSSPIPRRNVLRAAAFCNDTRLFTVYIQPRITMPPKQATLGKFFGAKGSRPEPQQSKLSFATKAAPKKAVERKADAPDAAVKKENSRKRTRSPSPANKASSPKVKDETTEEDEEDEPATKRPRRVRQRIVEEEEEDEMMNEVPAKSSVGSPKASRTKKSSPLKPTKAVKAKADAPDSSRSKRASKSPSPTVVVEHEKEEATESASEDDLAEDDEEDIKPAVAKKTLEKVQMRLKTQTKDPYPDWKQGEPVPYAALCTTFSLIELTTKRLEIMAHCSLFLRQVLRLTPDDLLPTVLLMINKLAPDYAGIELGIGESLIMKAIGETTGRSLAVIKQDQKEIGDLGLVAVKSRSTQPTMFKPKPLTISGVHKGLMGIATVSGNGAQGRKVDAIKKLLSAADSHSSGKVDISKDKGGPSEAKYLVRFLEGKLRLGLAEKSVLVSLAQAVAFHEADAKGQVPKTTDVEQAEAILKTVYSELPSYDVIIPAMVEHGIMNLREHCKLKPGVPLKPMLAKPTKAITEVLDRFEDQTFTCEYKYDGERAQIHYVAKSADEEISQSLPGATKAAADGVASIFSRNSEDLSKKYPDILAKLHTWVKEDTKSFVLDCETVAWDVEEKKVLPFQQLMTRKKKDVKIEDVKVKVCVFAFDLLYLNGEAIVERPLRERRDLLEDAFQPVEGEFSFATHMDGQELEQIQVFLDESVKASCEGLMVKMLDGSESGYEPSKRSRNWLKIKKDYLSGIGDSLDLVVLGAYHGKGKRTSVYGAFLLACYNPSSESYETVCNIGTGFSEAVLEELHTQLSDIVIDRPKPFYAHSSGGQHQPDVWFEPRYVWEVKTADLTLSPRYKAGCKEGVDPGGEKGISLRFPRFIKVRDDKKPDEATSSRQVAEMYRKQESVTKSKGPAADDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPM0</accession>
    <name>A0A1B7YPM0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_02689</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162480.1">
        <property type="nucleotide sequence ID" value="XM_018297664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPM0"/>
    <dbReference type="SMR" id="A0A1B7YPM0"/>
    <dbReference type="GeneID" id="28861771"/>
    <dbReference type="KEGG" id="chig:CH63R_02689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02689"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="452"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR13963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="513" mass="58151" checksum="A0C6B2824F74173D" modified="2016-11-02" version="1">MPTLGFLKKKRTREANQDSQGSSLPTSPVTPTSSKPFDSSISTTISSLSSNSQHGLKQHDDPASSEAAKQQQMYPVTVHPPSQPPYNHPAGSQQNLPSINNLINPTQQDGSNNGHNYLAQPTQSSQPNPSPGTDPARLQQQQAQSMLHPPPPQQQQQQQQQQQQQQQQQQQQFGMQQQAVDQQVRQTKGKYTLTDFDILRTLGTGSFGRVHLVQSKHNQRFYAVKVLKKAQVVKMKQVEHTNDERKMLGEVKHPFLITLWGTFQDSKNLYMVMDFVEGGELFSLLRKSGRFPNPVAKFYAAEVTLALEYLHSRNIIYRDLKPENLLLDRHGHLKITDFGFAKRVPDKTWTLCGTPDYLAPEVVSNKGYNKSVDWWSLGILIYEMLCGYTPFWDSGSPMKIYENILKGKVKYPAYINPDAQDLLEKLITADLTKRLGNLYAGPNDVKNHPWFTEVTWDRLARKDIDAPYTPPVKAGAGDASQFDRYPEDPERYGSSGHDEWVRPLEYGHLFTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQ18</accession>
    <name>A0A1B7YQ18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SERAC1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_02863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162654.1">
        <property type="nucleotide sequence ID" value="XM_018297838.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28861945"/>
    <dbReference type="KEGG" id="chig:CH63R_02863"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02863"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="696"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="TANC1/2-like AAA+ ATPase lid" evidence="9">
        <location>
            <begin position="897"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1451" mass="161008" checksum="FDC7D9B5B16B9E67" modified="2016-11-02" version="1">MSAPTAQMIALEGLTVLDGAVEGEMAVDYVFLHGLNGSPKDTWTDETKDGTGFFWPRQVLADIPGCRVMTFGYNAAFERALVKNTTTINAIAQTFVNRLIDKRKGEHINRPLLLIAHSLGGLVIKRALYNIHADRHTGLKSRKIDEQNAIYDSIAGLVFMGTPHAGSHVTDAARVKMLKALARATFKKAPENLIRALSAHSNELQDLSASFERTTIFTQHMIEICTYFETKTTKFVVPRAMTSLHYLNEREEGIAKEHTKMAKFSDAQDDMYQSIRQRLADMGTDGLNAKTARQATYRVSQIPGDIARTQLAQFLHDQCQLGPTDNIRVHSLAARSGQRQSTKTATASFSTVPPLLLKKQSRWVIPFVWGNNHSHIVVDTDFHGFTALNGVEADKHVMDIIAIPGLGCHPFSVWQEDPSASTYMWLRDDPALLATGTQILLYGYDSGHQSSNGPASIDDIAISLISALRDIGRSSPSAKPVVFLAHSMGGVVLKQCLVELANTSQSELFILRSVKMCIFLAVPNQLPVPAMLAVMLGNNRFNKLRYALQAERNRGYLSTLDGIVRGFGQANGIRFCSGYETMRSTLPKRQIHAESDHTILLPKSQAIQDGSRAVDQFPVSKAHGSVLGMQAGSQTIDTIARLVTEASEASMATQDVDFDSASSEDIKNSALYRQFVKTLVLHGRDREDGIEAAVQGTFGWVWSNPEISLGSWLTDDKAPLFWIRGKPGSGKSTLIRYLWGHNQLSTLLADEVPGVSRIKAAFFFYYRGTHVQKSFEGMLHSVLLRVLEQEPRLSSVLLPEFARLKHEEREKWVWTSATLMKAYDDILTQTKLSVEIYLFLDALDEYDGPTEAIVNFVRTSVLKASSGRTRLKACFSSREWLAFEDPFSALPGFKIHEYTDSDILKYTLARLSRNPEISQRLAAGTHQEASDVRQMEEHIVNSANGVFVWVKAVSDEIVSGFSKTKSTSELLTLLKSLPTDLDSFYTDAIKRLPFELRMEAFSMFEVMARSDTILSATLVREAVSCAQLSDPQDCAMAIRRCRELPGSDSPTRWAQDRGAGLVEFKHPYTNAPAIITFMHQSVLDFVLRPGFRGLVLDHAFALPLENGYSILSKWMLSIGAQDQKVFEYHEVGEDLLAVAEATTGKSLRSFLDSLDNDTLTTELKMWGCPIADISNPKMYFAVVQGLNIFIQEVIQEHGGVIPDKGNFSLLHCLAKLSDPYGAYGMAFPISRSPARLEIIPILFRHGARVGAVWQGKTPFQMLVSNFPYTIFTGSGGHKGWDSIPIYNYENVLALHLLSAGQDPNVSISIKRNYIRRQDRSTEWVTCKPLHLVPLGLAEILIAFGAKVNVFDSKGRTPLDLACGVGGNPFEVGDHVPPLEAYSFAQFLLSHGAQLSLEGSRIWPDFVKSVSRSVQVPEEFLQPGVMSRASPGVVLMKIEDMKLRIKRDGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQX0</accession>
    <name>A0A1B7YQX0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162871.1">
        <property type="nucleotide sequence ID" value="XM_018298055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQX0"/>
    <dbReference type="GeneID" id="28862162"/>
    <dbReference type="KEGG" id="chig:CH63R_03080"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03080"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="357"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="780" mass="84798" checksum="210900839CA045E9" modified="2016-11-02" version="1">MTAEVRRSNGTRLDASLGITERIAPSMTAWTGDMRKRYTDFQVYEINKDGSVLHLKETRLPPPPKDTTPALPPPPPSAPVVEEKKEEEAKTEDAAQNEDKSTAAVPTSAAEKPVVPEIPAEDLAAIASLTNEDFANQLLVLYQTISADQNAKTEPATSPIMDDKDQRSQLHQSVRRIFNSAIDTSTDPTGAIVARVVPPRGKGKGMRGGRDNNNNGNKQKKPKARAPGEGEYLHFTMYKENRDTMDALHQISKALRTKPQAIGTAGTKDRRAATTQRCSIRGQRADALVRARLNGVTVGDYLYAPTPIHLGAHAGNEFVIALKDCLVAGSPDLSPADRHAQIHDSVKAAMASMRSLGWINYFGHQRFGTHAVGTHEVGRLILQEDFESAVNAILAYDEAIAKRAAAGEVPEQAHARDDFSRHHACMLFREGGSAEEALKHLPRCFSAESSLIRHLGMSSGPSRRDFTGALTSITRGLRSMYLHAYQSYVWNHAASHRWRLYGEKVVEGDLVFADGSKPQANDAETTQDDDDAEFSDARPLTAEEAASGKYTIHDIVLPSPGHAVVYPTNAVGEFYTTFMRDNGGLDPTKMIRRQREFSLRGDYRKVVVRFLAEPGFEVRAYEDDNEQMHPTDMDRIRAARSGAGKKRARDEAEGQDGDNKKAKTETQGGETMGDEKMEDAPQTEEEKPAAGAEAKAEDAAAAAGSKPTAEKTKTAVVVRFQLPKSAYATVALRELMGVDESEVAAVPATTIAATVAAAAHKETDEAPKSAETETTSVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YR86</accession>
    <name>A0A1B7YR86_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163050.1">
        <property type="nucleotide sequence ID" value="XM_018298234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YR86"/>
    <dbReference type="GeneID" id="28862341"/>
    <dbReference type="KEGG" id="chig:CH63R_03259"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03259"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="680"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="920" mass="104688" checksum="E12DEA9A05C19D7F" modified="2016-11-02" version="1">MMEQTKRGTPKMNNDGSTLTEWPPIPQELRRQPSARPFNGQKQNSTNKYVEPTISEDRTRGSEFDKSGEIWAVVRSSTPPKDNSDDPSFDLIDLSLAPVANRDRPPTPSIQRNKQEMPMHQRTYKYQVPETNSPVRNRPAGLDMRPMEASAEPSGPRAYSDTHQSFPGRVLNLQNAEYGEFSGHLTVSLSQIADHLGIPEDSASSLDAMQSYISVLKSHANMPPERPKESRPLTIHRVFEDSRESHRTYLDPPQWIEGVLMGASPISNVQAYLAKHPEVCFIICRYYAGTSQLTNNKDTDAHGNLMVQHISESIVPVEGHLVSATRKFAIFSASTDSSATFTGDGCDNDDEWDNGSSAWEFSNGWLENDTIALSYPYLSFYHARGGSMDAFAKKLSVNELRQFQRVTDYILGEHEAEYSTVDALVARSKIRKEFLHYLFRPGIVVVEGRGAEARGYTSTSWLEHSSEPETPAKALSETHPDGSLEIDAWHWDFDGHFSKTKTKLKIEIKNTHDQQEKNINGLSLRPLKYVDRETRKRLRIRGEWVWKCRQQRIIAYRDASEKSHHTVDERHMIDMKTYQELHSNHSGLRVSSLIGPEQLKSEDPPDETFVYLVPLSMTGFNLKTKKWTDLSIDRFSEVQWNTGAFESLVISGKMKRLIQALITNQIEAEHSTDIISGKGNGIIMLLHGGPGTGKTLTAESVAEIARKPLYPVTCGDIGTEPREVEKYLESVLHLGKTWGCVVLLDEADVFLEQRSLEDLKRNALVSVFLRVLEYYDGILILTSNRVGTFDEAFKSRIQLAIHYTNLTTHQRTMIWGNFFRRLKDMSDEDIDFVDLEDHVEDLARHKMNGREIRNVITTARQVVRWERKQQKEPSFSLTYKVMDEVIETSRKFDSYIEKLNMGMSHDELAENEGLRLAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRZ5</accession>
    <name>A0A1B7YRZ5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BZIP transcription factor JlbA/IDI-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163241.1">
        <property type="nucleotide sequence ID" value="XM_018298425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRZ5"/>
    <dbReference type="GeneID" id="28862532"/>
    <dbReference type="KEGG" id="chig:CH63R_03450"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03450"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="151" mass="16898" checksum="80EAF7A9CA67844F" modified="2016-11-02" version="1">MVPSLPTQSYRGHGSPADLQGSFQTGLVETSRMQGYIGLCDVPSPNTDNANMARTGSVDEVLRPKPSGGSNRRRVQNYAVDDTGSVDEDNASTIRRQRNTIAARRYRQKGRDRIAELESALRVVEEERDRLKLELARKEAEVDALREVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSB4</accession>
    <name>A0A1B7YSB4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha beta hydrolase fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_00093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163430.1">
        <property type="nucleotide sequence ID" value="XM_018295068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSB4"/>
    <dbReference type="GeneID" id="28859175"/>
    <dbReference type="KEGG" id="chig:CH63R_00093"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00093"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="142"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="488"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="612" mass="67475" checksum="0548EE3E7B8F24F3" modified="2016-11-02" version="1">MYEVVEKMNSEKKTPGFLGPKEIETSGGPKAKGRAAVTAAALSLLALTALIRGNFLSAPPWSSSRHNEHHSGVPGQGSSTEWSWSSIKPSRALKWHSCFEDGGYDCARLDVPMDWQQPRDDRRVVLAIVRIRATDASDYRGPVIFNPGGPGGSGVWSMRNHGRMLHEIVGTNHDLISFDPRGVGASIPRLECWSSPQQGQSWELQDPGILDSHEGILGELFTRAAAYSQACERAMRPSGILEHIGTASAARDMLEIVHQTGNDKLRYWGFSYGTILGGVFAAMYPDKVDRLVSDGNVDYREWFNYAHVNFVRDTDKVLFAFYDFCHRAGPERCAFHAPTPEAVMQRFGELLSGLKAHPVIVPATDDDDDDNGPEVPLLVTYSKVMRLLSSTLYQPQDKFESFSRIIAALEQRDGRPFYEYYHPRGKPGPAPVCSTQPISPLEPLPGIIEGTEDAFPVIMCADHPAVLNLTLEEVQREAETLMELSPATGALAVPYQMTCNQRTTRPRWRFDGPFEGKTDHPILFIANRADNITPLLSARNNSAGFPGSAVLVQNSYGHTSLAAPSKCTRQYINAYFQNGTLPPAGTECEGDSQPFGPKVGPEARVYHNPLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTH0</accession>
    <name>A0A1B7YTH0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163856.1">
        <property type="nucleotide sequence ID" value="XM_018295494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTH0"/>
    <dbReference type="GeneID" id="28859601"/>
    <dbReference type="KEGG" id="chig:CH63R_00519"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00519"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="76925" checksum="A8F6891B3100029C" modified="2016-11-02" version="1">MAQTQSTPRIARVPYTLQTAPMDSKAVFEAMPTPLNRPRKLSQASTITVTSVNSARESFETRSRSSSYSSNRTSIDSRDSSMWRPEYMYQRPSQTTMFRKKAKPGEIFAKLPGEVLELILDELKKAHLDKGSQSCATCWMRDLSSVSLTARKWCKFARVALYEDIQLVGADSASQKKRHKLTFGTRMMLLRRTLRANPHLAGIVHTLKVPSPPTGIALEDYHNQVAALIMACPNFERLIGLHPQYNHSFNKLTHALSTRKRLKHMDWIVEPSPFQRQHRFKTSSGGKAAAFAQPARDYSVTPGDLQPHQSATFLDFHVDWAHLTTLTIHCLPGATLTPDNLISSALMHLTSLQHLFLSRIPVTSFNDGTLLSLPPLRTLSLTHVPGVTSSGISALATLPTSQAIQRLTLRHTNLESLPALARIFSNFTYLEAFTLVQSFAPTLPEDTFIWLMPYLASTSLRKLHWDITSNTANANAADSILARSIAAGGFPSLRSLRTPNDPEGIFQALCRPQERADSANDRFRGPNGPARSSSFPAPPNGNSPGSPTKQSRSPTAPASPTSMATAEMYRECGNLHHARLAAQARLEAARALPRFFVNVIDEDGTVLEKHGLAGFIGTAESRITYNLWPDAGARDERGGLVEMADLMASNGEDVAASGREGCQGRWNASPTLPDKKDKERWWHTERGRWYQPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVH7</accession>
    <name>A0A1B7YVH7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone promoter control 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164572.1">
        <property type="nucleotide sequence ID" value="XM_018296210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVH7"/>
    <dbReference type="GeneID" id="28860317"/>
    <dbReference type="KEGG" id="chig:CH63R_01235"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01235"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="622" mass="66060" checksum="AEE2B11FCEF02606" modified="2016-11-02" version="1">MRDSSSPELSSPPSGSISEPGSPLISRPNNNMDMDEIIVDPSQPRFGVLTGNEQPQPEVRLTAAGLPRKKPGRKPGSTVKPRNPDEPPKVRRPRKPRDPNAPPIQRKRKSAPAQDADAGSDSKSLAAAAASSSTPPPPRQAKTIDIAGITSDSRPGSAQPEHTAQKAPKREELPRSMQGILNAEPEVESKPHSAALPTRMSGHYDPIRGSYDPVRGIFGIASSPRPTTQPVNRPSASPSIASLVDPPAQNVTSPSTQTYGASTQSRTQDNASVPASPPYPARSAPQPISKPPAPDPKKALAPPPVPAAKTDAKLKDAVSTAGSVASKKPSPKQKPQKSGISSPKISALDEPRGDVLSDRSILDFGRAENGKEYKAPDIVLDIPIKPGDTNIYVNVMRMAEEKYGWDALHPRLAEKRDRKARIAAASAALEKTASGQESGDEMSEDSDKEASNVEMGGMTSGADVPEKPKKKKRNFKEDEYDKDDDFVDDSELLWEQQAAASRDGFFVYSGPLVPEVEKPIDTRPDGLPKRGRGSRGGRIGGRGGTTRGEGGTGRGGGPGSRGGRGSRGGSLTRKPRITKSEKEQLEREKAERQRQAELSAKSTNGYSLQPQTPSFAAGMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW33</accession>
    <name>A0A1B7YW33_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164773.1">
        <property type="nucleotide sequence ID" value="XM_018296411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW33"/>
    <dbReference type="GeneID" id="28860518"/>
    <dbReference type="KEGG" id="chig:CH63R_01436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01436"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601952" evidence="2">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="539" mass="58511" checksum="0F9C07A0428CC275" modified="2016-11-02" version="1">MKLSISCRLASLAVLPAFTAADWQYRSRPDLTPPRLNITTPAAREQVEQGLLFVAPYPGAGPDARNPVQPAAYIFQDNGDLVWSGLGYFAGGVANFGVDTWDGRQVLRAFQGQRGETEGRSYGHHVILDSKYEPVKLVRGRSNRLGSAHEFRIVDDVFALVEIGRTRPVGLSPWGGAKGQDWILSTGFQELNIETGEVVFQWESLDHVDPGNSAFPLAELPSTTGLDSSSAWDYFHINSVDKDSQGNYIISARATSAIYKINGTSGDVIWTLGGANSTFNIEPEAHFAYQHDARLLSRSPDGTTDVLSLFDNAAASPEKQISSVSRARIVQLSHSDNTAKALRTYPAPDGLSAQSQGNAQVLPNGNVFVNWGQAGAITEFGEDGEVLFHAYLDSGPGGSLVQNYRGFRSNWTGSPSEDPALVIVEGDARGKVEAYVSWNGDTEVTAWRFYAEPSLDRSPRLGEGRLALGEARRTGFETHLTLDVSRFRGEVLISAQAVDAKDRVLVHTSSETISRHSWGSPVPSRESSSLDEHGASEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWH0</accession>
    <name>A0A1B7YWH0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164914.1">
        <property type="nucleotide sequence ID" value="XM_018296552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWH0"/>
    <dbReference type="GeneID" id="28860659"/>
    <dbReference type="KEGG" id="chig:CH63R_01577"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01577"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="275" mass="30594" checksum="EBD0AD4726CCFE4B" modified="2016-11-02" version="1">MDEADNRPIREGPPPPPVLDDPPPPYVKEEELPSYPSANHREPAPGPPVPAPAPVLVPAAPSRFPPVFNGYAIDSWNFHLGASLSQKRFRLSVVSISLHTVIVYLHDGLDANDEILGKLVKEDCSSQHYHHVIWLPAVEGLRAEEEKILMHYLQEPRMMNRELYELVVDIGGVEERFQWRPSKGKEVKSVGKHAIGWKLVRMAAQQAGAGGWRKKRSEGFSSRGEEVVAVLALTFCETKKFTFLFLGSGRSGALGETWQTAALLSGVWRWAISGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1UV66</accession>
    <name>H1UV66_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_00713</name>
        <name evidence="7" type="ORF">CH63R_06303</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000222">
        <property type="protein sequence ID" value="CCF31867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018159128.1">
        <property type="nucleotide sequence ID" value="XM_018301278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UV66"/>
    <dbReference type="GeneID" id="28865385"/>
    <dbReference type="KEGG" id="chig:CH63R_06303"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06303"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="268"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF31867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="460" mass="48642" checksum="67EAD6A411738E6D" modified="2012-03-21" version="1">MTVRNPDADEKSGAAPGLRSNAPSETTLTPAADPNENDITTAAAATVPPPPPSTSVPGPVPDGGLEAWLQVLGSWVILAQTWGLVNTFGVYQTYYERTLQGTTPSAISWIGSIQGALLMMVGPISGPLYDAGYFRELLWAGMFLILLGLFMTSLCTTYWQVILAQGVCVGLGCGLTFLPSTAILSQYFNKRRALVMGIAATGSPIAGMCFPILFGHLEPKIGFGWATRIIAFILMGLSVIPAVTMHTRLPPSGHKRSLIDKTALHDPVFMLVVAGSFIGFLAMYVPYFYIQLFAVNHSIGPADFSAYFVTLLSAGSIPGRVIPNYLADKVGALYMQISVAAGSAVLMFAWLGIRNMAGLVIFAILYGLFSGGMVSVSPTVVVSLSPDLGRVGTRMGMMNFIAGIAILVGTPIAGAILGDYSEVAWQSMIGYGAAALTAGSMCLTLSKIFQLKKTARDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVE8</accession>
    <name>H1UVE8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04428</name>
        <name evidence="3" type="ORF">CH63R_13857</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000276">
        <property type="protein sequence ID" value="CCF31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151149.1">
        <property type="nucleotide sequence ID" value="XM_018308831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVE8"/>
    <dbReference type="GeneID" id="28872938"/>
    <dbReference type="KEGG" id="chig:CH63R_13857"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13857"/>
    <dbReference type="eggNOG" id="ENOG502SQ0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="58"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25982" checksum="8FFBD34FFB14180B" modified="2012-03-21" version="1">MATLGSKKSIRIGVMLEAVQLSDIMGIDLFGNLSRAYYNKVKDFDPEFAQWADHPAETEFFFISSTLEPAEMTPGLRFVPNVTYDDCPRDLDLVLIGGPLLNHRPPAADRFMREAFPKTRVWLTTCIGSPWLASAGVLKGKKATTNREFLKIVREIHPETEWLDQRWVVEEKEYDGEGKGELWTGGGAGAGLSMIITYLNKNFDPGFVQKLALEAIAFEELALNQFYKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWA7</accession>
    <name>H1UWA7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04674</name>
        <name evidence="4" type="ORF">CH63R_08373</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Will I."/>
                <person name="Young S."/>
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                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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            <strain evidence="6">IMI 349063</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR05247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="405" mass="44281" checksum="45C12D73769FECD3" modified="2012-03-21" version="1">MALAVVTASLILSGVQAQSLALAERSLPEKAQIIDQKSFNVLEVVPPPYEFNATSKFVWPGVTEESLKEKPFHIYDPEFYDIIGSDPSLTLIATSDTDPIFHEAVVWYPPTEEVFFVQNAGPIAAGTGLNKSSIVQKISLADVEALRAGSLDTPEVEVVTVPSNPQVINPNGGTNYQGQIIFAGEGQGDRVPSALYLMNPLEPYNTTLLVNNYFGRQFNSLNDVAVNRRNGDIYFTDTQYGYWQYFRPEPGLRNQVYRLNPKTGALTVVSDDFVSPNGITFSPDGTYAYVTDTGISRGRMGQNFTEPATVYRYDVNEDGTWDNRKTFAHTHARLPDGVHTDSKGNVYAGCNDGVHVWNPSGKLIGKIYTGTVAANFQFAGDGRMVITGQTKLFYATLAASGVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWW8</accession>
    <name>H1UWW8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_04857</name>
        <name evidence="11" type="ORF">CH63R_09992</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02000434">
        <property type="protein sequence ID" value="CCF32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154390.1">
        <property type="nucleotide sequence ID" value="XM_018304966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWW8"/>
    <dbReference type="STRING" id="759273.H1UWW8"/>
    <dbReference type="GeneID" id="28869073"/>
    <dbReference type="KEGG" id="chig:CH63R_09992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09992"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_0_1"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="109"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR05872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="566" mass="62150" checksum="8B1ECBD6976AF219" modified="2012-03-21" version="1">MASIPVTVSHQGTKYKVEIDTSSNGETFKYQLYSLTGVEPDRQKILVKGKQVKDDDDMSKFGLKAGATLMMMGKPSGENADLARPKEAIKFVEDMTEAEAAQQEGATPAGLTNLGNTCYLNSTLQTLRSIPELQSALTTYKSGSGGAGSSFGLSSTDIATQLMDLYKNMSETQGSIPPLTFLSTLRMVYPQFAEKSKTGAGYAQQDAEEAWSQIISQLKQKLSESEGSSFVDRYMAGELQSTLEVDEQAARDAGEEPIKSSESFLKLNCHIDSTVNHLRDGILAALTEKLEKKSAVLDRDTTYTKKSLISRLPKYLAVHFVRFFWKREVQKKAKIMRKVTFPHELDVVEFCTDELKKALVPVRDKVREIRKDEEDIERARKRRKINPVDRGDIAGASGGPEGKTALEKANDKKAERSGKHIATTSDGDTEMAETFKTDAEVEAEKDAALVAAKKELYALVNQDLVKDEGANQSGIYELRGVVTHQGASADSGHYTAYVKKTAPVDPKTGKKGEEDGNWWWFNDDKVSEVTPDKIDALAGGGESHSALICLYRAIPLPTIDNEGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXI2</accession>
    <name>H1UXI2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_00847</name>
        <name evidence="11" type="ORF">CH63R_01092</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">IMI 349063</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
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        <property type="term" value="C:U1 snRNP"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="LSm4/Sm_D1/D3"/>
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        <property type="entry name" value="LSM_dom_sf"/>
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        <property type="entry name" value="Sm"/>
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        <property type="entry name" value="Sm_D1"/>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
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    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
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    <dbReference type="Pfam" id="PF01423">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
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        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="79"/>
            <end position="124"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS52002"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="CCF32683.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">CH63R_01533</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000522">
        <property type="protein sequence ID" value="CCF32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018296508.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UXP1"/>
    <dbReference type="STRING" id="759273.H1UXP1"/>
    <dbReference type="GeneID" id="28860615"/>
    <dbReference type="KEGG" id="chig:CH63R_01533"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01533"/>
    <dbReference type="eggNOG" id="ENOG502SMPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022878_5_0_1"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578:SF1">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36578">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556024" evidence="2">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="463" mass="48313" checksum="BBC8C4CE218D5C8C" modified="2012-03-21" version="1">MLYSLFLVALAGFGTASPTVQPINFAAILSAPAPSLTGPPAYATGQTGVYNPAAASSIASVAVTGVASASATKSVVARDVLDKRNFCFFGFCFGGSQTWNTPAPQTTSKAVPSSTCASTTSSPAVTTTSKTTTPVTTASTVITSAASITTPPSTCTPISWTNTNSFTTATSCAAPFEVGTYCGFINPEDPCAVQPDGNGPRVQPDTVDAFLAYQEFHQDAQNAKTPTGYASTFKDLDASVNANSYLGLYTLKSYDVAQCASLCDSTKLCTGINIYVERDPSINPAGCTCSNPPSISNYKCTLWGSGVEQAAATNTGEGRNGFQVVIAGSNGYEKTNTTTPATPSGWTNPQNCSSVVHSHPSTCMGQNFFPGPFDANVCASYAASQNALNSKSLGIWSWASWFGYSPLRCNFFNAFMVKENGVAKGTYCSLFTQQYAPSAATYKPEFSVGISWGIESSWSFCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYJ3</accession>
    <name>H1UYJ3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_05309</name>
        <name evidence="10" type="ORF">CH63R_00032</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CACQ02000620">
        <property type="protein sequence ID" value="CCF33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163369.1">
        <property type="nucleotide sequence ID" value="XM_018295007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYJ3"/>
    <dbReference type="STRING" id="759273.H1UYJ3"/>
    <dbReference type="GeneID" id="28859114"/>
    <dbReference type="KEGG" id="chig:CH63R_00032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00032"/>
    <dbReference type="eggNOG" id="KOG1532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_1_2_1"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="403" mass="44476" checksum="DF066CCC09D63FD3" modified="2012-03-21" version="1">MASTSAAAPAENASTQENVPTNTPTSIVVVGMAGSGKTTFMRRINSYLHGKQDPPYVINLDPAVLNVPFESNIDIRDSVNYEEVMKQYNLGPNGGILTSLNLFATKVDQIVNLLEKRAAPDPENPNKKPINNILVDTPGQIEVFVWSASGTILLESLASSFPTVIAYVIDTPRTTSTSTFMSNMLYACSILYKTKLPMILVFNKTDVQDATFAKEWMTDFEAFQAALQRDEMSDVIGGYETSEGGSGGSGYMGSLLNSMSLMLEEFYSHLSFVPVSSRLGTGMDEFFAAVEEKAAEFKQDYLPELQRRRQEREEKKRQAREHELDKMMKGMSVDAGKKSMVVKPVDDDDDGIDVASDVDDDDMPDDEDDREGLQARYEAAMEAEGDSIMADGSFAKYLHTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYN1</accession>
    <name>H1UYN1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05343</name>
        <name evidence="4" type="ORF">CH63R_05330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <organism evidence="17 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02001285">
        <property type="protein sequence ID" value="CCF34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018298860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3L5"/>
    <dbReference type="STRING" id="759273.H1V3L5"/>
    <dbReference type="GeneID" id="28862967"/>
    <dbReference type="KEGG" id="chig:CH63R_03885"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03885"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012699"/>
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            <dbReference type="ARBA" id="ARBA00019988"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCF34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="542" mass="60169" checksum="245B34C2153F0AB0" modified="2012-03-21" version="1">MAHWPSAVQAVALVCAGWSTFVYIVQSMGIIRIFLSYSSRLKPAVSSSLQKQDVPHITIIRPVKGIEHGLYDCIASSFRQDYPRNRLTIYLCVAEKSDPAYPVLVKLVEDFPGFDARVLVEDEDPLLHGRDGHIDNLGPNPKVRNISRAYREAKGDIIWVMDCNIWIAKGVAGRMVDKLLGYGPDGSRVKPYKFVHLLPIVVDTVSPRDISTETQTLLSSSEGGSSQVASSGHSPSLLDYVEKQGGGRLDEMFMATTHAKFYSAINTVGVAPCAVGKSNMFRKSHLDTVTDPLQNPILPAGKNLPKGIDYFSEYICEDHLIGDLLWRSKLPGMKNHGLVMGDLAVQPMAGMSVRAYFARRARWLRARKWTVLAATLIEPGVESLLCCAYFAFAVTTLPWFHDTFGTAQTWGAMGLYWLAFVTIWMVCDWFTYNRLHAGYTMEVDENTPKFARGTATPGGAPPRSFLEWLPAWIGRELLAMPIWTWAVFCGSTVNWRGRTFNVRSDMSVVEIGSQPSTASHGVLNGLTNAEGTHRSRSKDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7T3</accession>
    <name>H1V7T3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectate lyase</fullName>
            <ecNumber evidence="5 13">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_07889</name>
        <name evidence="15" type="ORF">CH63R_11563</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="5 13"/>
    <dbReference type="EMBL" id="CACQ02001912">
        <property type="protein sequence ID" value="CCF36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR04860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018153378.1">
        <property type="nucleotide sequence ID" value="XM_018306537.1"/>
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    <dbReference type="AlphaFoldDB" id="H1V7T3"/>
    <dbReference type="STRING" id="759273.H1V7T3"/>
    <dbReference type="GeneID" id="28870644"/>
    <dbReference type="KEGG" id="chig:CH63R_11563"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11563"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="441042at2759"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Pectin_lyas_fold"/>
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    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF8">
        <property type="entry name" value="PECTATE LYASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556288" description="Pectate lyase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR04860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="237" mass="24539" checksum="DC817C1BA6D89D87" modified="2012-03-21" version="1">MAIAKIFSTALLAGLVAAQTLTIPTRTGSIISLSLPSLISGSRDFGNREFDRGRACETDVLSNGGEPVFILEDGASISNVIIGQGQVQGIECRGACTLKNVWFRRGCDYSILLSGNGNVLVEGGGAKAAEVIYHKGRGNVTVKDFTAIDSTYLYRSCGSCSNNGGPRNVAVSNLKANNVKLVAGINSNYGDTASVTGSCGTAVAKVCQEYKGVDRGLESPKVSTTANCKGQLSLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7V4</accession>
    <name>H1V7V4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein DUF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07905</name>
        <name evidence="9" type="ORF">CH63R_12912</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001921">
        <property type="protein sequence ID" value="CCF36306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152303.1">
        <property type="nucleotide sequence ID" value="XM_018307886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7V4"/>
    <dbReference type="STRING" id="759273.H1V7V4"/>
    <dbReference type="GeneID" id="28871993"/>
    <dbReference type="KEGG" id="chig:CH63R_12912"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12912"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_3_1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF36306.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="483" mass="52846" checksum="BF057E3C9728475F" modified="2012-03-21" version="1">MSEQKRNSENHSPSQNLGAKTRFDDTSDNTEETYGRLSIASKMSRSHDHTKRPLTLPDPDSFRRLSASPFQNGRTSPSLAADYSSPMIRPPRETTKLARFWLANKGVVLVALSQLFGALMNLTARLLELEGEGMHPLQVLFARQSVTMACCCTYMYCMKTPDFPFGQREIRWLLIARGVTGFFGIFGMWYSMMYLPLAEATVITFLAPSVAGYVCYLALREPFTRNEQIGTVIAFFGVVLIAHPTSLFSGDLTSSAAAAAAAANAPEQHGSGNGTIASTLPGLHHQTTTAERLTAIGVAILGVFGAAGAFTTIRWIGKRAHPLISVNYFATWCTIVCTVVLTAAPLLEIGQPALRWGLPQTPRQWLFLVLLGMFGFVMQFLMTAGLGTDRSNRANAMVYTHMLFAAGFDRFIFGNVMGWMSLAGCGLIIGSALWVVLTKKTPVPKREAVADVEVANVRDTEAVPMLADMDGGRDDEFELQMVR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9A9</accession>
    <name>H1V9A9_COLHI</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002156">
        <property type="protein sequence ID" value="CCF36812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CCF36812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="340" mass="37504" checksum="6884E1BC3C4CF788" modified="2012-03-21" version="1">MPVQLLPASAAAFAPRASSVNVVLGSKVEPWLTQTLKRINRVKRPLNSVPQHQRCLTETLSSPDAIWTLTSIMLPKAPESELRQDSNPLVEALFNYQLLHIEAYIVHVDMVLRNEVAFKLTTDSIDALVEYHKDVHCVDSKANPYDWPEKDQQCKKLHEDFVQAINKFVFRTHVSALEGLEEDGVGELLSGKSEEVKNNIMGLMKPLLPPPPRVVDVIRQPPLLPSSPANASIWSQPPTPAHLPTVDAWRVLPSSPSIASTSQESTPIWANIGMSEVQIPSPTPSFSQPFSTAGFYYSAPAITAPIPALPLPSMFTPQCGVSVGYGSFGWDRYQEYATTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9R7</accession>
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        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
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    <gene>
        <name evidence="6" type="ORF">CH063_08409</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002237">
        <property type="protein sequence ID" value="CCF36970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306141.1"/>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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        <property type="entry name" value="AKR_Detox_Biosynth"/>
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    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
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    <dbReference type="PANTHER" id="PTHR43364:SF9">
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF36970.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR04464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="361" mass="41068" checksum="803C1234D3774EC7" modified="2012-03-21" version="1">MASKELPARLKEGLENTKVEYRQLGKSGLRVSVPIFGCMSFGDSRTLGWALNEDEALPLLKAAYDRGLNTWDTANVYSNGASEVTIGKALKKYNIPREKVVILTKLFFAVGEEPEARHFSYREEFQRSKDYQNQWGLSRGAIFNQVEASLKRLDTPYIDLLQIHRFDPSTPIEETMKALHDLVLTGKVRYIGASSMWGTQFAQMQFVAEKNGWTKFVSMQNQYNLLYREEEREMNRFCNDTGVGLIPWAPLCRGHLARPPKDFGTTSRSKGEKESQPGSHGTVEPDLTIIKRVQEIAEKRDWPMSHVALAWINKRITSPIIGFSSVDRIDQAITADGKVLTDEEEKYLEELYQPKAISGHR</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAK7</accession>
    <name>H1VAK7_COLHI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_08640</name>
        <name evidence="2" type="ORF">CH63R_03389</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002383">
        <property type="protein sequence ID" value="CCF37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163180.1">
        <property type="nucleotide sequence ID" value="XM_018298364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAK7"/>
    <dbReference type="GeneID" id="28862471"/>
    <dbReference type="KEGG" id="chig:CH63R_03389"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03389"/>
    <dbReference type="eggNOG" id="ENOG502SNR5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088979_2_0_1"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="189" mass="21173" checksum="38E6B043AFED2539" modified="2012-03-21" version="1">MAAPEEASILNMTGIWSLNPIESDDLGPTFMLQNIPWIVRKVISYASLELKMDQKDPAPPERPATVIDINQTVRPGGFDTANSYILDGETRHDKVPIFGAMSMRAKYVPKAEVSGEDLMGHEIEQPSPTDERVGIKEFTEGVNTGWKTTALWGFEKVNGERRFCKYCTTTKGDEKVQARLVYDYRSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBL3</accession>
    <name>H1VBL3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_08906</name>
        <name evidence="5" type="ORF">CH63R_02938</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002547">
        <property type="protein sequence ID" value="CCF37616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162729.1">
        <property type="nucleotide sequence ID" value="XM_018297913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBL3"/>
    <dbReference type="STRING" id="759273.H1VBL3"/>
    <dbReference type="GeneID" id="28862020"/>
    <dbReference type="KEGG" id="chig:CH63R_02938"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02938"/>
    <dbReference type="eggNOG" id="ENOG502S57S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040566_1_0_1"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497643" evidence="2">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="33"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF37616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="265" mass="28959" checksum="97487F8C801ABD10" modified="2012-03-21" version="1">MRFSTLIAAAVFAVCASAVPAPLPQRSAKITAPKAGVYTIPEGGTYSNRMTWDFSKLADGAKIPDGLRVSGYPVSNTHVFAVQNTFIKGGYLNLKVDGGQKAMPYKSAEVVTTVTNIKYASVRTVAIFTENPGVCNGIFFYKNDNQETDIEWLSDAASQSNAGKRQVWFANQSTGSKSPKSFKAVPPPANPTSTEHEYRIDWLPGVVRFFVDGVQTWETKQSVPNVPGPWVFNNWANGDKGWSAGPPAKDAIFRIKEIDMYYNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCA6</accession>
    <name>H1VCA6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YDG/SRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_09095</name>
        <name evidence="6" type="ORF">CH63R_05288</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02002673">
        <property type="protein sequence ID" value="CCF37859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161509.1">
        <property type="nucleotide sequence ID" value="XM_018300263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VCA6"/>
    <dbReference type="STRING" id="759273.H1VCA6"/>
    <dbReference type="GeneID" id="28864370"/>
    <dbReference type="KEGG" id="chig:CH63R_05288"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05288"/>
    <dbReference type="eggNOG" id="ENOG502QRDQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033920_1_0_1"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="190"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF37859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="360" mass="39826" checksum="D9F6899B5003F9E1" modified="2012-03-21" version="1">MATPPTPSGQQLAQYFGDVKGKGLIPLEALARANVSEKDSRVLGLVRKASIFLNYAKRCELAFPAAVPRDLFNAKYPLKSCLVKIFSPASPSVKKKYFSEKMKTRAKELHEWADRVEDSVRIAHKAAQEAKAAKPVTNKAANGETIPPPADHEIWGRGGIMHGLALRPTDRFTVALNPVYTEEKRPANVYGHNGLTVGDWFPNQLSALFNGAHGSSNAGIYFQKDEGAFSVIVAGAYQDLDVDKGEIIFYSGSNSHLNDDSESILPSTEANKSLAENNVCSNPVRVLRKAHKGSRWAPSHGYRYDGLYEVYEKRLPKNTKNGTFEQYHLVRLPGQTPLRDLRSNPSAKQISDLAKSRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VCF8</accession>
    <name>H1VCF8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arginosuccinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_01794</name>
        <name evidence="6" type="ORF">CH63R_13144</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF37911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR04017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VCF8"/>
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    <dbReference type="KEGG" id="chig:CH63R_13144"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13144"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
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    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
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    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
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        <property type="entry name" value="Arg_succ_lyase_C"/>
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        <property type="entry name" value="Argininosuccinate_lyase"/>
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        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
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        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="4">
        <location>
            <begin position="353"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF37911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="488" mass="53602" checksum="C4BE5B544D36DF34" modified="2012-03-21" version="1">MGYGVSPEDLPVPGRDTFFWLGEINKASAVINSDEGLLDRAAAIRIASGLQKLLDSANEPNAPRPSLVITFEPLLIQAAGVEATLLHAGRSSQDMLTTVSTMVLRDAVLKLASQLHDTTRRLVDMAETHATTLVPNYTNGVAAQPNSYGHYLLGHVAGLHRDAERLRQCYTRLDRCAMGTTVLNGTSWPLNRERMAQYLGFAKVVDNAYDAAQISAAEMPVELGAIASQVALHAGAYIQDVMAQYSQPKPWILLREGGYNTYVSSAMPQKRNPGLLNNTRAEASRVVTLGVGRAIQGHNLPPGMVDAKGLADNLAVLNGATRVLRDWQRILDALVIDGKRSLKELDLDWTASQELADVLMREHNVPFRVGHHFASEVVRYAKAEDLCPSEFPFAEASRIFADTLKHTNLENGGFRFLSEDEFREALDPAGIVNRRATSGGPQPKEMERMIGGSKKILEDLEVWIQERRAHIEDSLHGLDVAFKLLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDX6</accession>
    <name>H1VDX6_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Putative Reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_09515</name>
        <name evidence="4" type="ORF">CH63R_02992</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002973">
        <property type="protein sequence ID" value="CCF38429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162783.1">
        <property type="nucleotide sequence ID" value="XM_018297967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDX6"/>
    <dbReference type="GeneID" id="28862074"/>
    <dbReference type="KEGG" id="chig:CH63R_02992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02992"/>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_685134_0_0_1"/>
    <dbReference type="OrthoDB" id="3548481at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF38429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="402" mass="43131" checksum="7ED05732CFA6B090" modified="2012-03-21" version="1">MESITLAADDEHQGLLLATPMPDTTELPAAPDAAGPRFQGDLLIFPRAEARILPTTASDGPPTPFILNLFADASFPMTKHHRGPSTPSQPAGAAVLWKPWPGLAGHDPWHSRAFQVLACQDFCEAEVFAVVAALETAALLSHLMPELRQVTVFTDCKDAIRKLIAAAENASDTLVKRAVAASLALDAKGVRALVRWCPGHVGIEGNSKADELAKEARYYNFRHLVPRQQPASVCGYEIPGEYLERARRGDWWEDGASQPPRTDKKQVSIWRDCEQVEAPQDDGIVTPQPATREVPPRKRQRTDEGPGPSGRHALLPKGTGMGVSVAGDQDGIVAGFIARSRETPPPTAAVNGAVERSEVADTSTQQIGASPNVSDSEEEDGNDTRSLTLGRSPEAGDEASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VE68</accession>
    <name>H1VE68_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_00287</name>
        <name evidence="4" type="ORF">CH63R_08730</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003013">
        <property type="protein sequence ID" value="CCF38521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155727.1">
        <property type="nucleotide sequence ID" value="XM_018303704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VE68"/>
    <dbReference type="STRING" id="759273.H1VE68"/>
    <dbReference type="GeneID" id="28867811"/>
    <dbReference type="KEGG" id="chig:CH63R_08730"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08730"/>
    <dbReference type="eggNOG" id="ENOG502SHG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_138_11_1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF38521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="603" mass="68636" checksum="69733B3CED2C6BC2" modified="2012-03-21" version="1">MWLISTETSKLHAFIPPDVPPYAILSHTWEAGEVTFQEFADLDAAREKPGFAKIDKTCELARQNGLEWVWVDTCCIDKSSSAELSEAINSMFEWYRLSAVCFAYLADLPVGSPSLWMFESESGIHKRPCRWFQRGWTLQELIAPSRLEFFDVGWNSRGFKTDGTVLRQLSSMAGIRGKTARVLKNSDAIGEISIAERMSWASKRQTTRTEDMAYCLLGIFRVNMPLLYGEGPRAFIRLQEEILKNSTDMSLFCWTASEETIQPYRGLLARHPSEFASWFDTELTSRKSISWAMCEQEKEFSSTNKGIRMEATLASFFYDGEERTCLRCTLFPDEYVVFVALRYHRDNIYVRELPKVIIPSRTTRYEQKTIYIAKDVDERMSTSLQETAAEALSFDTSLLPASFSLEVAECWPKKQWHPRRKEFALTGSKLFSCTVVYTVAFDGVQIGEVFLICQRHASALQPLRYALIPSRHAAGIKKGILDHETGDDQGNPPFEAFSMMEQFIIDGRQEVKLWHGETCFSLFVTRYSETGESTNQLFLKATSSDDLLHPMPVRLPIQRSIGDGNEPDQRLERAPQIGGDVGVLVVQQPNPMDILEAERENTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFU5</accession>
    <name>H1VFU5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02057</name>
        <name evidence="5" type="ORF">CH63R_08634</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003312">
        <property type="protein sequence ID" value="CCF39098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018303608.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VFU5"/>
    <dbReference type="GeneID" id="28867715"/>
    <dbReference type="KEGG" id="chig:CH63R_08634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08634"/>
    <dbReference type="eggNOG" id="ENOG502SUJB">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_139687_0_0_1"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF39098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="172" mass="19489" checksum="C564581DC236F697" modified="2012-03-21" version="1">MAEQTYEPKASVGGHTLARANLDDVPAIQSMTRAAYSKYIDRIGKEPAPMKADYNELIKTQLVYVLRNDKTNEAVGAILLRHDPATKALHVNNLVVAPDAQGRGYGRVLMRCAEDVARVCRCTNLQLYTNVKMFENLALYPKLGFVETERKTEDGYERVFFRRDLEEGVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VG02</accession>
    <name>H1VG02_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_02072</name>
        <name evidence="4" type="ORF">CH63R_05939</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003345">
        <property type="protein sequence ID" value="CCF39155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158764.1">
        <property type="nucleotide sequence ID" value="XM_018300914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VG02"/>
    <dbReference type="GeneID" id="28865021"/>
    <dbReference type="KEGG" id="chig:CH63R_05939"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05939"/>
    <dbReference type="eggNOG" id="ENOG502S6AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_2_2_1"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
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        <property type="entry name" value="NUDIX_hydrolase_dom"/>
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    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF39155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="199" mass="22104" checksum="51446D627F5150AB" modified="2012-03-21" version="1">MAVSNFVTSQYSSEAFVESCGAVVFDLSKEPAKVCLLHYLALDEWYLAKGRRNCGESRHEAALREVLEETGVRCRLLPVDMPTRAPAPDDDANAPDVAAARRAITEPFTLTIRSTDKGDGVKLIWWYVATVEGRPDGEEKEEKEKEEEEVMAGGEAQFAAKFFVCNQAVEMLTFENDREVLRKAIDLVGKPISKSQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGN1</accession>
    <name>H1VGN1_COLHI</name>
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        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_10234</name>
        <name evidence="8" type="ORF">CH63R_03088</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03088"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RIX1_N"/>
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    </evidence>
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    </evidence>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1VH56</accession>
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            <taxon>Colletotrichum</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003565">
        <property type="protein sequence ID" value="CCF39559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VH56"/>
    <dbReference type="STRING" id="759273.H1VH56"/>
    <dbReference type="GeneID" id="28870970"/>
    <dbReference type="KEGG" id="chig:CH63R_11889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11889"/>
    <dbReference type="eggNOG" id="ENOG502SACR">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_026944_0_0_1"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF3">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G06020)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="493" mass="53239" checksum="0B4540E4639EA08A" modified="2012-03-21" version="1">MVPYIDVSHLPSSASFYSAILQPLCIHYISADAQTASPDVDTKAVDTESETTITLSDPSRPLTNVTYGTSSPHTPVLQIREARNSIEPLKLSHVVFSAPSPTAVTDFHSCAVRANPKLLSVVPFGQLSRSRPATITQSGDIHRATVTDLDGNTMEVVYQPPPNYPPFYAGSTVRKTQSTTEEVGRILNWNYDVVASVPSPSMSGSATAGPSTSILAMTARSGQFPGDEPYTLLRRSVTTSVIESPVRREDHAPAHASAPASNGVPTSTVVGSLLGAAVGAAAGAAITYGMMRKERARAPLQEFDGSTPPFQRRATFPDQYAEPQAGPGRYVEVERTVEKIRYPEAYPTLPDDRAPPQYMAKYSQVGARSRAVDDMYEDTRSRHSSRYQLERGSSVRSSSQAAVPRTAPLMLTDYEHRSSTGSRHSERDVAIDRSPAPSHCRDDTWRREQSTEPCAKPCANPSTEHSSEPCANEGAQPTSDCCPEQGSHNSGSQ</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003699">
        <property type="protein sequence ID" value="CCF39793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157460.1">
        <property type="nucleotide sequence ID" value="XM_018302682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHU0"/>
    <dbReference type="STRING" id="759273.H1VHU0"/>
    <dbReference type="GeneID" id="28866789"/>
    <dbReference type="KEGG" id="chig:CH63R_07707"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07707"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_1_0_1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF39793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR08942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="551" mass="60320" checksum="E8143CD11792884E" modified="2012-03-21" version="1">MTDIIISQAPPALSIPSEKEKKYDRQLRLWAASGQAALESASILLVNSGSGTVGVETLKNLVLPGIGKFTIADNSTVSEADLGVNFFLDESHFGKSRAQSCTELLLELNPEVQGDWYPRNQEAWDLHRLLDSPSPFTVILYTLPMEPEDLKTLESYSREQKTPLVAIHSAGFYSYFSIRLPSVYPIVDTHPDATSTTDLRLLDPWEELEAFAEGMTRDIENLNNHDHGHLPFVVILLHYLKVWKASHNGAAPSNYKEKVEFRKMVADATRTDNPEGGEENFEEAVAAVLKTILPPLLPSAVKQIFEYTHANDSVAKSTFWVIADAVRDFYERHQCLPVPGGLPDMKAQSSVYIELQNIYKAKARKDAAEVLASVRQKPGGEGVDPAEVELFCKNAAFVKLVVPASGGTEQLRTVAGKHPSVKIVEDGGVDAHHFLEQEFANDEMAKEGVLPLSLLPVYLALRSTSHTGTASPDDILAKIESLVPGTADNERLTQAAQEVSRAGGGELHNVSAVTGGMVAQETIKIITNQYVPIESTCVFDGIASRCQILHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIL2</accession>
    <name>H1VIL2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_10734</name>
        <name evidence="8" type="ORF">CH63R_08674</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02003851">
        <property type="protein sequence ID" value="CCF40065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155671.1">
        <property type="nucleotide sequence ID" value="XM_018303648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VIL2"/>
    <dbReference type="GeneID" id="28867755"/>
    <dbReference type="KEGG" id="chig:CH63R_08674"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08674"/>
    <dbReference type="eggNOG" id="ENOG502SSGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079951_2_0_1"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF40065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="164" mass="18385" checksum="49744272A9838121" modified="2012-03-21" version="1">MAFDRIVQFILRGAQLAFAAIVAGITGSYLHSSNASSWDNGRFIYTIVVASLSLLFALLWLLPFSASFIHWPMDIFLSILWFIAFGLLVNLIGDGCGPVFDWSNVSPRGDACGRNKANIAFCFLSAIVWLASALVGLFWVRRRNAVADTRHTHGRRRWYRSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VIR8</accession>
    <name>H1VIR8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">CH063_02282</name>
        <name evidence="12" type="ORF">CH63R_05453</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
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            <strain evidence="13">IMI 349063</strain>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
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        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
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        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
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        <text evidence="2 9">Belongs to the SLX4 family.</text>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:5'-flap endonuclease activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
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        <property type="entry name" value="Slx4_ascomycetes"/>
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        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
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        <property type="entry name" value="ATHOOK"/>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ96</accession>
    <name>H1VJ96_COLHI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10906</name>
        <name evidence="3" type="ORF">CH63R_09277</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004030">
        <property type="protein sequence ID" value="CCF40361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150598.1">
        <property type="nucleotide sequence ID" value="XM_018309355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150728.1">
        <property type="nucleotide sequence ID" value="XM_018309485.1"/>
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    <dbReference type="STRING" id="759273.H1VJF8"/>
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    <dbReference type="KEGG" id="chig:CH63R_14511"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14381"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14511"/>
    <dbReference type="eggNOG" id="ENOG502RNQP">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_1677777_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
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        <property type="entry name" value="NUDIX"/>
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        <location>
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            <end position="18"/>
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            <end position="158"/>
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            <end position="154"/>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="158" mass="16698" checksum="3D7560926CDE3666" modified="2012-03-21" version="1">MHPSFLSLAACFVLAVGANPVKPGSVDEGGSRSRCGVVAFEGNGKVWMVHSKADGLILPKGGYDSDKDSNMEDCVVREAKEEAGVDVIRSSIVALSVDDGSVHWFKCKVSGHGTRTDASLEGRKPPRALPVADAMTELKKDSKGKKKGMQKALKAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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        <name evidence="11" type="ORF">CH063_02485</name>
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            <taxon>Sordariomycetes</taxon>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
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    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
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        <property type="protein sequence ID" value="OBR10302.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
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        <property type="entry name" value="Ub_conjugating_enzyme"/>
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    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
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    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
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        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF40989.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR10302.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="180" mass="19812" checksum="4F598A2513E623D9" modified="2012-03-21" version="1">MDYSMEDTQNAAPGSVQAAKLGGTKKGPDAQSVTKRLQTELMQLMTSPAPGVSAFPSADGNLMSWTATIEGPDQTPYAGLTLKLSLSFPTNYPYAPPTVLFTTPIYHPNFDFSGRICLDILKDKWTPAYNIQTVLLSLQSLLGEPNNSSPLNGEAAELWDKDFEEFKRKVLARHRDVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPB6</accession>
    <name>H1VPB6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPFH domain/Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_02749</name>
        <name evidence="7" type="ORF">CH63R_08502</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02005123">
        <property type="protein sequence ID" value="CCF42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155499.1">
        <property type="nucleotide sequence ID" value="XM_018303476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPB6"/>
    <dbReference type="STRING" id="759273.H1VPB6"/>
    <dbReference type="GeneID" id="28867583"/>
    <dbReference type="KEGG" id="chig:CH63R_08502"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08502"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_024949_1_1_1"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="56"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR06981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="390" mass="41576" checksum="EADDBDC075BBC986" modified="2012-03-21" version="1">MASAVTKAVLSPPLRRALVQSRGFQTSTKSLLPSAFGSASSIPPSYFQKPSLPANTVIRFVPQQTAWIVERMGKFNRILEPGLAILVPFIDRISYVKSLKENALEIPSQSAITADNVTLELDGVLYTRVFDAYKASYGVEDAEYAISQLAQTTMRSEIGQLTLDHVLKERAALNTNITAAINEAAQAWGVTCLRYEIRDIHAPAGVVEAMHRQVTAERSKRAEILESEGQRQSAINIAEGKKQSVILASEAMRSEQINRASGEAEAILMKAKATAAGIDAVAKSIANGEEAAQGAMSLSVAEKYVDAFAKLAKESTAVVVPGNVGDIGGMIATGLSVYGKVGQAQAKAMAKQIVNKESEGESGDDAHAPKEPKALKDSVLESFDEAAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VR16</accession>
    <name>H1VR16_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNARE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_02891</name>
        <name evidence="13" type="ORF">CH63R_12629</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02005567">
        <property type="protein sequence ID" value="CCF42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152020.1">
        <property type="nucleotide sequence ID" value="XM_018307603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VR16"/>
    <dbReference type="STRING" id="759273.H1VR16"/>
    <dbReference type="GeneID" id="28871710"/>
    <dbReference type="KEGG" id="chig:CH63R_12629"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12629"/>
    <dbReference type="eggNOG" id="ENOG502S813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053570_0_0_1"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000060">
        <property type="entry name" value="SNARE complex subunit (Syn8)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="281" mass="30871" checksum="05C7E1E12F7BE587" modified="2012-03-21" version="1">MSNLNQLYLLADHIKLSLLERQRAQSLNLDADTQDGHISRSLDQFKDGLEFLDSEAKRLQAASDESAAQNITDSLPALQKQFSDLTSQFHGFSNPSTSSITTSPNDPLLSPDFAAAQSTKPLKGSLRGLPGSAPNKTVRFTDSPGGSRGAEDLEAAALFGEGRYRDDPVDTAGYRDQAEGLDNQQLHAYHSQIMRDQDDHLDRLGESIGRQRELSMQIGDELDSHVAMLDEVDEVVDRHQGRLDRARRSLGKVARDAGESKQMIAIIVLIIILVLLIAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VU11</accession>
    <name>H1VU11_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_13342</name>
        <name evidence="6" type="ORF">CH63R_09006</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006326">
        <property type="protein sequence ID" value="CCF43719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156003.1">
        <property type="nucleotide sequence ID" value="XM_018303980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VU11"/>
    <dbReference type="STRING" id="759273.H1VU11"/>
    <dbReference type="GeneID" id="28868087"/>
    <dbReference type="KEGG" id="chig:CH63R_09006"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09006"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="469"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF43719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="565" mass="62125" checksum="5C642B269B36EE73" modified="2012-03-21" version="1">MPIKSRWSEPIPNCSLQTWIFGSFFNPLSDRKAFYDADRPDTHYLTFSDYRTVAKQIAIGLKAAGLKPGDRVLLFSGNNLFFPVLFLGVLMAGGIFTGANPGFVTRELAYQLKDSGATFMVAAEGSLDTALEAAKQVSMPTSNVFVFDTTIPGSGKAEKPARDGARHWTELIAPRLQAEKFEWVEPSDARTTTCCLNYSSGTTGVPKGVEISHYSYVANGTGVVKVSALEQDHEASLARSVGLCFLPLYHTYAQTYFVANFAKQGIPVYIMAGFDFVKMLTYIQRYRVTQLVSVPPILVALTKHPITAKFDLSSLESVGSGAAPLPADVARQTERILKKDDLIVRQGWGMTEVTCTAMTWDPTRLERSSSVGELMPNYQAKLVGEDGKEITEAKVPGELWVTGPTVMRGYWRNPNATKETIVTDAEGNRWLRTGDVAYVQEYKTGGLFFIVDRMKELIKVKGNQVAPAELEALLLERQDVADAAVVGVTLDGEELPRAYIVRSPGTNATGEEIAKWLEKRVSKHKRLKGGVAFTDVIPKNPSGKILRKMLRDKAKQEVGNSVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VU12</accession>
    <name>H1VU12_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_13343</name>
        <name evidence="4" type="ORF">CH63R_05547</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006327">
        <property type="protein sequence ID" value="CCF43720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158372.1">
        <property type="nucleotide sequence ID" value="XM_018300522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VU12"/>
    <dbReference type="STRING" id="759273.H1VU12"/>
    <dbReference type="GeneID" id="28864629"/>
    <dbReference type="KEGG" id="chig:CH63R_05547"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05547"/>
    <dbReference type="eggNOG" id="ENOG502QS8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_49_0_1"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF43720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="333" mass="37033" checksum="7842EAA0795C75D1" modified="2012-03-21" version="1">MSVSYIKSLVFGGSSPDISAETSASRSSECQSVPEPDTSDTLTLPDGRKIGYAQFGLATGKPVFYCHGLPGSRVEAGHLHKAAMDVGARIIATDRPGMGLSTFQHGRTLLDHPKDLEQLAEHLRLPEYAVMGVSGGGPYALACAASMPREKLKCVSIVCGIGPPDIGMAGAGWFHWLGFTYGWRYAPRLAGWFFHRQGRFHLSDEERLELQLQEAEKNKATFPRQENGIWDDREIVGRMVMTSRQYYAQGIDGVSHDGYLDGTEFGFRIEDIRSDLPVRLWYGKDDTFVPANHGRQIARRLGTNAHLRVEDDTHASIFFRWRKEVLADLVSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VUE4</accession>
    <name>H1VUE4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_13438</name>
        <name evidence="3" type="ORF">CH63R_00575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006424">
        <property type="protein sequence ID" value="CCF43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163912.1">
        <property type="nucleotide sequence ID" value="XM_018295550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VUE4"/>
    <dbReference type="GeneID" id="28859657"/>
    <dbReference type="KEGG" id="chig:CH63R_00575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00575"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_0_2_1"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="111" mass="12750" checksum="7E9E7AAB1160421C" modified="2012-03-21" version="1">MFTPTRRLFQKAHACRITLFARDGCGLCVRAKSALSNVWDRRPFAFTEINITAPDAKSWRDLYDFDVPVIHISKAEAPEEDPKLVGKAVKLMHRFDPDQIEAKMDQVECKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVZ3</accession>
    <name>H1VVZ3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_03325</name>
        <name evidence="19" type="ORF">CH63R_04417</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="CACQ02006878">
        <property type="protein sequence ID" value="CCF44404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160638.1">
        <property type="nucleotide sequence ID" value="XM_018299392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VVZ3"/>
    <dbReference type="STRING" id="759273.H1VVZ3"/>
    <dbReference type="GeneID" id="28863499"/>
    <dbReference type="KEGG" id="chig:CH63R_04417"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04417"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="278"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF44404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="478" mass="54597" checksum="177A2167B44AB0E8" modified="2012-03-21" version="1">MSTPEERAVAFKNDGNKAFAAHDWPKAIELYTKAIELNDKEPTFYTNRAQANIKSEAYGYAISDCSKALELNPKLVKAYFRRGLAQTACIRPKDAVVDFKECLRLDPNNKDAKLKLDECKKIVRKLDFFAAIEVGDEPSAAEGLDISVINVEEDYDGVRLEEEMTQEFIDDMTERFKKGKKIHKKYVYQIILAVKKIVYDEATMVEMEIPEGTQLTVCGDTHGQYFDLMELFRLNGTPNDKHYYLFNGDFVDRGSWSTEIALLLYAYKWLRPKAFFLNRGNHETDDMNRVYGFEGECKAKYNERIFKLFSESFSALPLATLIGTKYLVLHGGLFSDDKVTLDDIRKLDRHAQRQPGQAGLMMEMLWTDPQDEPGRGPSKRGVGMQFGPDVTKKFCENNGLEAVIRSHEVRMDGYEVQHDGRCITVFSAPRYCDSTENRGAYINIGPDYELQFQQFDAVPHPDIKPMAYAQSSLMSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYE2</accession>
    <name>H1VYE2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">CH063_00548</name>
        <name evidence="33" type="ORF">CH63R_13998</name>
    </gene>
    <organism evidence="32 34">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="34" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="35" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="CACQ02007568">
        <property type="protein sequence ID" value="CCF45254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151290.1">
        <property type="nucleotide sequence ID" value="XM_018308972.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1VYE2"/>
    <dbReference type="GeneID" id="28873079"/>
    <dbReference type="KEGG" id="chig:CH63R_13998"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13998"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_5_0_1"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000007">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2430:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28 32" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1697"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="CCF45254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="OBR02772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2100" mass="232767" checksum="163B81422926878E" modified="2012-03-21" version="1">MYGAGTGPQTGVSTPRSNASLRPLTLRHGSLETSLLVPTALHFHASQLKDRFNATLPTATDELAQDDEPSSVAELVARYMGFVADEVEKGEDDESGSYEEVLKLVLNEFERGYLQGNEVHALAATLPGIDAKKLVVIRSYYQARQTTGRSIKAYGSALFRAADDGSADIYTIFGGQGNIEEYFDELREIYKTYQPFIGELILNAAELLQTLSKHPEAEKLYPKGLDIMRWLESEDETPDVDYLISAPVSFPLIGLVQLAHYEVTCKVLGVHPGLLRDQISGTTGHSQGIVLAAITAAAESWESWKELAPSALTILFWIGARSQQVFPRTSLTPTMLRESVDNGEGLPTPMLSIRDLSQAEVQKHIDATNKYLPADRHISISLINSPRNLVVTGPPISLYGLNAQLRKVKAPTGLDQNRIPHAQRKLRFVHRFLPITAPFHSKYLAEATELIDEDLKNIKIPSKALGTAVFDTNTGKDLREAGDSNIVPTIVRLITRDPVNWEKATVFPQATHVLDFGPGGISGLGVLTSRNKEGTGVHVILAGAVDGSITEVGYKPELFDRDEEHAVKYAVDWVKEFGPRLVTNSNGDTYVDTKMSRLLGLPPIVVAGMTPCTVPWDFVAATMNAGYHIELAGGGYFDPGMMTAALKKIEGAIPAGRGIGVNLIYVNPRAMQWQIPMLGRLRAEGVPIEGLTIGAGVPSVEVAQEYIDTLGLKHISFKPGSVDAIQAVVNIAKANPTFPVILQWTGGRGGGHHSYEDFHQPILTMYPRIRRQANIILVAGSGFGGAEDTYPYLTGEWSRNYGYPPMPFDGTLFGSRMMVAKEAKTSPAAKQAIIDAPGVDDSEWEKSYTGPTGGVITVLSEMGEPIHKLATRGVLFWAEMDKKIFSLPKEKRVPELKKNRDYIIKKLNDDFQKVWFGRNRAGEAVDLEDMTYGEVVRRMVDLLYIRHEQRWIDPTFIRLTGDFIRRVEERFTSTPGQVAQLQDFKDLQSPYETVEKILSHYPDAETQLINAQDVQHFLMLCLRPIQKPVTFIPTLDENFDFYFKKDSLWQSEDLGAVIGQDVGRTCILQGPTAVKFSKVIDEPIKDILDGIHLTHVEYLTRDLYKGDKKAIPTIEYFGGKLIETDIPVEDVDGLTVSYDDAHKNTYRLSTSPTATLPSLDAWLALLAGPDRSWRHALLTSEVVVQGQKFQTNPLKRIFAPARGLFVEIQNPKDPKKTKIIVKEQPRHNQYVDVIEVKLEGQNDIVVNMIKDTTALGKPVALPLKFTYHPEAGYAPIREVMEGRNDRIKEFYWRAWFGDEKFDLDADVSSKFDGGKATITGEDINDFIHAVGNTGEAFVERPGKTVYAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNEFRMKPGAEPLKKGDEVSTTAQINAVINQESGKMVEVCGTIYRDGEAVMDVTSQFLYRGAYTDYENTFQRKMETPIQLHLATSKDVAVLKSKQWFNTDDLPRDLDLLGQTLTFRLQSFYRYKTKTMYSSVSTQGQVLLELPTKEVIQVASVDYEAGQSNGNPVVDYLERNGTPLDQPLHFENPIPLSGRTPLQLRAPATNENYARVSGDYNPIHVSRVFANYAALPGTITHGMYSSAAVRSLVETWAAENNIGRVRSFHASLVGMVLPNDDLQVKLQHVGMVSGRKIIKVEASNKETEEKVLLGEAEVEQPVTAYVFTGQGSQEQGMGMELYASSEVAREVWDRADKYLLDNYGFSITNIVKNNPKELTVHFGGPRGKAIRQNYMAMTFETVSADGTIKSERIFKEIDEKTTSYTYRSPTGLLSATQFTQPALTLMEKASFEDMKSKGLVPRDCTFAGHSLGEYSALAALAEVMPIESLVSVVFYRGLTMQVAVERDAAGRSNYSMCAINPSRISKTFNEEALQFVVDCISEETGWLLEIVNYNIANMQYVAAGDLRALDTLTGVTNFLKQQKIDIEEMRGNIDEAKGALKEIIKGSAEATLKKPTPLELQRGFATIPLRGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPAKLVGKYIPNVTAKPFAITKEYFEDVYKLTNSPKIASILANWDQYTQDGPAATAVNGEHEGPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2B8</accession>
    <name>H1W2B8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_03920</name>
        <name evidence="11" type="ORF">CH63R_04846</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02008900">
        <property type="protein sequence ID" value="CCF46631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161067.1">
        <property type="nucleotide sequence ID" value="XM_018299821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2B8"/>
    <dbReference type="STRING" id="759273.H1W2B8"/>
    <dbReference type="GeneID" id="28863928"/>
    <dbReference type="KEGG" id="chig:CH63R_04846"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04846"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005595_0_0_1"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF46631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="773" mass="85445" checksum="95842E36C15D60F6" modified="2012-03-21" version="1">MLHEILLALSGHPSPLLRTDNPDPNALSTAVSPPERELLATAGHLSDLHVKLQGYTAPIAAEHPSTICRAVATAVQSVHLAAFQRKVLEVEETILRRDSSLVGAYNIVPLTAVVGEFSEWTRRMEWLWEIVQFMLKKQQGQTCRGAHLIDRLRGELQSGYVDIERTAMSLVSVAETAWLKQVSAWILYGRLPSFGGDDFFVQKMDTGDQDYVSVPALLPKFVTPVVASSMLFIGRSLNHVRVKGSVESGLQGLDHLSSQLKELSALTYPLNTASFSRAITSVRLTLSRTILLKLLPLTKVVEALQILREFFLLGRGEFAMALTQQADEKLRSRWKRSDNLAYEKREGLGTFAVKEGEAAAVLAKTWAAMGLMQGQHADEDEGLEIARELLRLNLTKSKPAVPIKLEASVSRPTAKTLATTPFRNLLLSIPVVLTMQIPSPLDMFLTPSDLQIYSTINSYLLSIRRAHIRLTELWKITSLRRHHPAPPSPPAGSTRVGRAKVILLRQRYATRSNALRSAWVTCSTALFFLSETEAYLQTEVVAGLWDGFHAWLTSSEKENSHAAAASGASIKAAAKPATEDEEGDGDDDIWLAQSASDNKPAAKPIDSNPTHDPQSLATAHRAYLRALSTRLLLTFPSYTDPLYNLLTHTDHLVALTQRLHAVWTSMDLEADAGVVDAFVDLEIEETEVRSAIRDVEKHVKDGIRDVIAALRSLEADPAAFADEEEGGEEGVLREEGEYVPRRVGGVERLLMKLDLAGWFGERKDDFGFVFSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQL0</accession>
    <name>A0A1B7XQL0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_14615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150561.1">
        <property type="nucleotide sequence ID" value="XM_018309589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQL0"/>
    <dbReference type="GeneID" id="28873696"/>
    <dbReference type="KEGG" id="chig:CH63R_14615"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14615"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="130" mass="13871" checksum="CE8880E83414824F" modified="2016-11-02" version="1">MLLALINAGAVPGRWVPGYLSDRLGRFNMLIATILGCGMSLACLWLTSGSSPALLIAFAVVFGFFSGGNVSLAPVCIGQLCTIESYGRYYSTANVLEKSFNQSQGSFRNLIIFTIVSYAASFICLIIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQZ4</accession>
    <name>A0A1B7XQZ4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150694.1">
        <property type="nucleotide sequence ID" value="XM_018309451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQZ4"/>
    <dbReference type="GeneID" id="28873558"/>
    <dbReference type="KEGG" id="chig:CH63R_14477"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14477"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="315" mass="33983" checksum="141B5F82FEC4678A" modified="2016-11-02" version="1">MCEVTFAPEGRKRTSRGGRDDAIPDSQLPPVGVVRDGARFNSVSPRFLVKSAGVNKRQFATGSIFDDTLRHSSGHKGRNADIAALRPGAGVQAIVMQYLTLITLSPPASTGELEECPWFRAKTTTPRRQSLSQVKTLPFVLQQAREGLEEGQDSNGPVPLIVDRLIHHLVMLYPNLHCRDELTACRFTGGYGYAAAGQSNQRLPGPCDERSATLTKSRRAAKGSPPAPLGVAVGTSRPLDSRRFRQDPAAALWTDNEVPISSPNAVTGWYGPLVLAGARRGTAHGEPVRMHSDLAGPAPAFLAAPQQFSTYIVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XS96</accession>
    <name>A0A1B7XS96_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor IF-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151176.1">
        <property type="nucleotide sequence ID" value="XM_018308858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XS96"/>
    <dbReference type="GeneID" id="28872965"/>
    <dbReference type="KEGG" id="chig:CH63R_13884"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13884"/>
    <dbReference type="OrthoDB" id="4851651at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600988" evidence="2">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="401" mass="33276" checksum="74EC90F97D30FA62" modified="2016-11-02" version="1">MRVSILAAALVATPILGYPLTSDLATRDDSKLSAFDNVKRLLTGSGSPGVLSSIRRRDYGYGGGGGGGGPSSPGGGGPSGPGGSKPSGPGGGGPSGPGGGKPSGPGGGGYSPAPGGGGPSSPGGGSSPAPGGGKPSSPGGGSSPAPGGGKPSSPGDGYSPASGGGKTSGPSGGGPSGPGGGYSQASDGGKPSGPGGGGPSGPGGGYSQASDGGKPSGPGGGGYSPAPGGGGPSSPGGGSSPAPGGGKPSSPGGGYAPAPGGGKPSGPGGGGPSGPGGSGPSGPGGGYAPASSGGKPSGPGGGGPSGPGGGGPSGPGGGSSPAPGGGKPSSPGGGYSPASGGGKTSGPGGGGPSGPGGGYAPASSGGKPSGPGGGGPSGPGGGGPSGPGGGAPGGGGGGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSU5</accession>
    <name>A0A1B7XSU5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151343.1">
        <property type="nucleotide sequence ID" value="XM_018309025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSU5"/>
    <dbReference type="GeneID" id="28873132"/>
    <dbReference type="KEGG" id="chig:CH63R_14051"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14051"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="471" mass="53907" checksum="B3771AE72EFB72B6" modified="2016-11-02" version="1">MPPRKRRAASPPAEAEKAPSRRSRRVSSTPKKSSYFEDRDDDDHDYEGDAKAEDESDVPESEVDDDEEEDPPKKRGRGGPKVQVAKPKVQNVKSKVKTPQKTTGARAVKKQKVEESEDDYQDKQLDEDDKGEEDEDEDDFEGERVTFIPHVKLRPLDGMDYSDDTVHKNTILFLKDLKAHNQRSWLKSRLHSHSLLARRKSNTVAGHDAEYRRALKDWNSFVETISPKITEIDFTVPELPAKDLVFRIHRDIRFSKDPTPYKAHFSAAWSRTGKKGPYACYYIHLQPGSCFVGGGLWCPEASHLQKLRASIDERPQRWRRALNDERFKSTFLPKAAKKGGDEAALKAFAETNKGNALKTKPKGYLVDHRDIELLKLRNFTMSKKVDDQIFTKEDAQEKVCEIISAMHPFITFLNRIVMPDLDDEDDSEDEDGDEDDLDDGQENDDAEENGNPEETDDEEEGEGKDWSTHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU88</accession>
    <name>A0A1B7XU88_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151828.1">
        <property type="nucleotide sequence ID" value="XM_018307411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU88"/>
    <dbReference type="GeneID" id="28871518"/>
    <dbReference type="KEGG" id="chig:CH63R_12437"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12437"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="527" mass="56270" checksum="AE9DB32B17471AD4" modified="2016-11-02" version="1">MTLTTTIELANAPATPLPELSGSSSACSPQPQQTVFLSETEQHEDLSRGKTVVVISSVTCITGVSSLLAGIVTVCIPAMARDVNLENNLLLWPSSVYALTCGCTLLLSGAMADLYGARQLYLLGCFFQSVFTLACGLARTGIQLILFRALAGVAISMCLPSAVSIITHAFPAGRRRNTAFASMGGGQPIGFSIGLSIGGVFTDTIGWRWGFHIAAIINTVIFLVALKWLPGLGRREAVTWRRFRTEVDWIGAFLASGFLSMISYVLAIITDSTHEMKKAENIALLFISASLTGAFVAWVERQERLGRPAIIPNSLWKNRSFSSICLSVFMVWGAFNATEQLSSFYLQYVQRLSATNTSVRFLPAPMGGVLASIVAGLVVHRVRADLAILVAVALSSLSPVLMAVADPAWSYWLCVFWAMFMNAIGADMLFTISNLLITSLFPARTQGVAGGVYNTIAQIGKSVGLASSGAIASAVTARSGVADKASPAALLEGYRASYWYCLGLYGATLVVTIWGLRKIGKVGVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV29</accession>
    <name>A0A1B7XV29_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_12721</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152112.1">
        <property type="nucleotide sequence ID" value="XM_018307695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV29"/>
    <dbReference type="GeneID" id="28871802"/>
    <dbReference type="KEGG" id="chig:CH63R_12721"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12721"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="588" mass="64293" checksum="D9B8DAA44F5C9A35" modified="2016-11-02" version="1">MPTLALTNFNIVVGLLGGWISLFGLVSFLCKETYYLSEALISLLAGVAFSPSAANLIRPLDYAGTPANVEAVTLAFSRLVLGVQLVLAGVQLPSRYLRTQWKPMALLVGPVMTCMWIATSLLVWALTPRLPFLHALAIGACVTPTDPVLSNVIVKGRFADHNIPSELQNLIISESGANDGLGYPFLFFALYLIKYIGDGGEQVPGGAGLAMGLWFGETWGYTIVLSVIYGAVVGWLAKRLLRWAERHKYVDRESFLVFAISLALFIVGTCGMIGSDDVLACFIAGNAFTWDDWFRLETEDDSFQPTIDMLLNVTIFIWYGAVIPWDDFLHNDVIPIHRLVALGVLVLLLRRLPFVFAVHRWIPQIEQAKQAIFVGFFGPIGVSAVFYLYVTIEFLHTLNEGHEPRADVAHMAEAVRVIVWFLALCSIVVHGLSIPLGKLGYYAPRTLSRGMSFMSGDGGDDSGPFRIRGRVLFPFGRSRSEGADGPTSFDAESRAYSQSENEGSRPIYRIGGSVIPQRSVGAEESDVSALEPRRPDQPGQYPGPEHGGGSAQTKAAEHLSPAPPPPELQSRTIRFPDETPVPRGLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV72</accession>
    <name>A0A1B7XV72_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152195.1">
        <property type="nucleotide sequence ID" value="XM_018307778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV72"/>
    <dbReference type="GeneID" id="28871885"/>
    <dbReference type="KEGG" id="chig:CH63R_12804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12804"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="97" mass="10854" checksum="C7D8CFA156E2E588" modified="2016-11-02" version="1">MSGGRQAAQRKQPAASEGKKAARRPSAGLAALLSDEEELNRQPRHWIQCVLLDDSNALRRDRDDGPEDWVARFAGEDKSVDGLVWGKWDDLPPEWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW38</accession>
    <name>A0A1B7XW38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152472.1">
        <property type="nucleotide sequence ID" value="XM_018308055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW38"/>
    <dbReference type="GeneID" id="28872162"/>
    <dbReference type="KEGG" id="chig:CH63R_13081"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13081"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1246" mass="140604" checksum="D751F8E747A03107" modified="2016-11-02" version="1">MDDKSSGRTPSTRTFASSQLFFIPPPLQQIHKPQEYRKKIQRVELLNLTGTSIRSQVFYLLLQPSSYGVNYRRCLAKQQAVARIPIMDPFSVSSGVAGLISLGITVCKGLNIYCQDYRSRDVDILLLGQHAERLEAFLQLIKSRTDGAVVANHSLSNSFQECFTACDVCLQDFKTLNAKYSQPSAVQGLRERGKTVIRQLQYPFQKDKFDNLKSQMEDFRSAFLSLLLLMNHDLAKELQENTRADAAQLAMTICAQTQKTQDRIAANIPDMEVVVERSLAKLDHSLQERLFNLENAIALSLQSSKPSLPPGQPADDMGCYRLLQEPQSIHQEPGEYASIFKDSRNKHRLPADPHSLLRDRQEKEFLTVVALPNESSVSPLPPSLLCSCWVSLRQSRSRIPANRQPQHDKQCALFFLNKNTRAFGGNFKLLGCLFKWKMTLQYSSFLMRSLSIQPNLTVRAVVDYDAGAHGVINRLRRRANLIKKRGWEDLHWTLSRGLIEIHEMFKSGRAWPTDVDKYGRNIIHLEIQTILTFYLVPVHMQLQFGYTQLTRAAFDYGLLFQALIQKSENDVRRLLLSSTDLIFERGHDNQTPLHVAILWPRGLRLLFELAGLACDSIIDARDSAGHSAICCAIDLQQVESVRILLDHDAPLDLEHTGNFSHPAVLYLSPPRKVFEVLSNELSCRRRQLLSIALKNLPDTCISKLGLRSVSMIQTNATEVIDHLKLQHVDIPQICHGARPGTIYHSPKMSVTLAESLFRAGFTEVDFLIEGYSPLMTIEPSAYFVINGCSPASNFIKGFLSPNRPEVFPPRMWEAQAIPPGLPFVLASFQECVTGQDYEKCVYDAVRVCTFAKLGMHHTCCSYRHFRGEIPRDKFHGTERCGLRVMEPAEVAEIQEEDRHTAELLEMLMAEFEARLQSHPEPLDHFVSDYWWRRMSQVEAEREQIGDDDIQAMRDIGVFDFKIDTDIFMIVCGGVADCRSVWHKPHASLSLSGELNGVTMVAITLPLLASLAASPSRLGIVCARFKEPLEPWAGVASSTYLYAKGGVPQTNDSVPHAAFRAYVPLRNIGREGHTHLYHIVSRYDELDDVTIFTQADPFDLLAPAVKTAEDMARRAAAEVGADDVSPLNPGLFHDVADWGRIDWNSSAQRLWITPGQGRTLQRAPYTPGEFWTKVLGGRHPAAIRAMHGGIFAVRRETIRGLPRAVYETALAEFEKANSTNPEVGFFMERMWAPMFSRKYWLTSVQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWC8</accession>
    <name>A0A1B7XWC8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152585.1">
        <property type="nucleotide sequence ID" value="XM_018308168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWC8"/>
    <dbReference type="GeneID" id="28872275"/>
    <dbReference type="KEGG" id="chig:CH63R_13194"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13194"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="457"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="794" mass="87755" checksum="D27BE69DE0D73D2B" modified="2016-11-02" version="1">MASDQVPESNVDVLIIGAGPSGLMAAAWMAHCGVNARIVDKRNSKILCGQADGLQCRSLEIFDSLGFADRAWKEANHMIENPGNDGIIRRSDRIPDTIVGLSRFQQIVLQQGRIERFFLENIKKHSKDQIRVERGVLPESLEIDVSKVDDDSAYPVTVKLRQLSEEEAAPPQAANASRVPDGLFRSNLVQDDDEEDLIKMSRARAGESEIVHAKYVIGCDGARSWTRRALGLELQGEATDFIWGVMDIIPITDFQRRIADIRMRCAIHSAENGSLMVIPRENKLVRLYIQLKEVTPDASGRADRSKITPEIIFGAAQNILSPYKIDYEYCDWWTAYQIGQRVGTTYDAHSRVFLAGDAVHTHSPKAGQGMNVSMQDTYNLGWKVALAVKGIAKRDILSTYQSERRRVAQDLIEFDHRFSRLFSGRPAKDVMDAEGVSMEAFKDAFLKGNLFASGLSVDYGASNLVVKAGDALKQGDGSKALRGVATISEKEFRRKQALASGLPVGMRFNSFKVLNQACARPWHFQERLKADGRFRVVLFAGNVLDASQKARVDRFCAALDAPDSFLHRATPPKAPIDSVIEVLTVHSAKRTDTELLRDFPDILHPFDPHTGWDYNKVFVDDESYHEGHGEAYRNYGIDRQRGCAVVVRPDQYVAWIGELEDFDGLQKYFEGCLVLGHRVANGINGTNGVNGHANGVDGTTLPIRRPTQHKQVVTISSNRQHEGSSVPPVLVNLAASASAVGVDLHTNNDCNGINSDIYYGIDGSSSPYLSGVFHCSALGFHIAYKTKSTPSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWM3</accession>
    <name>A0A1B7XWM3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf500 and uba ts-n domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152677.1">
        <property type="nucleotide sequence ID" value="XM_018308260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWM3"/>
    <dbReference type="GeneID" id="28872367"/>
    <dbReference type="KEGG" id="chig:CH63R_13286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13286"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="203"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="407" mass="43544" checksum="461502E5E716F06B" modified="2016-11-02" version="1">MIFRHKRKPTAQEAESQSTYSSSPDTSSSSSSSAARSTLSRRLSLSHTLSSLRPRPPDPDAPPVIKPPGRGIGAHVHKITTTAGIPFNKAAHLVGAEGWFPQTMPRECAKAARILRSFTDQPLGDTEPAPSHARGEPFHPLGVTRRSIVTIPYQVLAHCAGLAIFNTLRAGAYMGSLAAGSGLVVARRPDGTWSPPSSFVVSTLGAGFMFGLDIYDCVLVLNTPAQVAAFTHPRISLGAETSVAIGPVGTGGAVEAAVSRTSRSMYSYMKSRGLWAGVQVDGTIILARQDCNSVAYNERGISARKILQTQAEWPEGSMPLWQTLIALEGRYAMDPDIARELAMMGPPGDFTPPMEEDEEEEPAPAYTPRAAPQFRSTYGGEEGVMNANQNGVEPSAEQKEMMLRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXL5</accession>
    <name>A0A1B7XXL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153020.1">
        <property type="nucleotide sequence ID" value="XM_018306179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXL5"/>
    <dbReference type="GeneID" id="28870286"/>
    <dbReference type="KEGG" id="chig:CH63R_11205"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11205"/>
    <dbReference type="OrthoDB" id="4844175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="94" mass="9824" checksum="11D4B55004E68442" modified="2016-11-02" version="1">MPSSPNQTQSHSTYESVPRPRRDQTPQTYTYQQAGASSTLNAWLSEADSKAPFHAVGGYRPMTTASGSGANMWGSAPAPSSTGATYGSGRSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXR6</accession>
    <name>A0A1B7XXR6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH63R_11243</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153058.1">
        <property type="nucleotide sequence ID" value="XM_018306217.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28870324"/>
    <dbReference type="KEGG" id="chig:CH63R_11243"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11243"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="147"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="765"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1087"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="650"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR04540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1576" mass="176837" checksum="98E54A670E884F24" modified="2016-11-02" version="1">MIPKTMISNEVYLLPLNDDGSPQVAGEYVYIAPKTNDPVTIRFAIEGTSSVCRHGSLWVNIPEQGAEFHRHEFREFKLKPDFNRTIEISVPIFQAGAYAFYTTYAELPDLAEELDATPQSTTSAVTNKKTPLYYIDVAPRLTLDGRPLPLPALSIFSVISKFMGKYPTDWEKHLRGISDRGYNMIHFTPLQVRGASNSPYSLYDQLGWDPDCFPAGEKDVRGLVESLEKQYSMLSLTDIVLNHTAHNSAWLQDHPEAGYNLVTAPWLESAWLLDTKLLELGDNLEKLGLPTEVKSDEDLIKIMDAIKKHVISEIRLWEYYAIDVERDVDAALEAWVAGRATSPEHAAGGASVAGLKDASQKDHAQFLIEHGLQGADRMGERFRKTVDPEAASGLLSVIFGRYEGEEGSTPTKAAARSKLVSLFDEINLPFYKEYDTEIGEILQQLFNRIKYCRLDEHGPRMGPINKEFPLIETYFTRLPKNDTTAKNKPEENVLVNNGWVWGGNALIDHAGPESRVYLRREVIVWGDCVKLRYGNGPSDSQFLWDYMTKYARMLAKYFAGFRIDNCHSTPLHVAEHILDEARRVRPDLYVVAELFTGSEEMDYVFVKRLGLSALIREAMQAWSTGELSRLVHKHGGRPIGSFEVDEISKADSKSPMSPMSPSVEGGDMLNGSSPSSREIIRRIKPVPVQALFMDCTHDNETPAQKRDARDTLPNAALVNMCASATGSVMGYDEIYPKLVDLVNETRLYTSESSSKPVKVGGGRNGIGGIKKLLNQIHTLMGKDGYDETHIHHEDQYITVHRVHPESRKGYFLIAHTAFPGYGNGNGAFNAVHLGGTKARHLGSWMLEVDAGDEARKDVLDDKKLLRGLPSRVVDVPGVRMEVKGDDTIITVRDKFPPGSIALFETWIPAAEHSSGLDNYVTSGARSAVENLNLVDLNFLLYRCEAEERDGSGGKDGCYDIPGHGKLVYAGLQGWWSLLKDIIRDNNLAHPLCQNLRDGQWALDYIVGRLERISKTADFDRLEKPAVWLKERFDAIRKIPSFLLPRYIGLVLRTLYNASWERGLGLMNDNVREGQWFLQSLAMVSVQETGLVKSASLWPKKLVPSLAAGLPHFAVEWARCWGRDVFISLRGLYLGTGRFDEAKEHILAFASVLKHGMIPNLLSSGALPRYNSRDSIWFFLQCIQDYTKFAPNGLDLFKEKVKRRFLPYDDTWFDVEDSRAYSQESTIEDVIQEALQRHASGMSFREANAGPSIDSQMSDEGFNISIKPDWETGIIFGGNQHNCGTWMDKMGESERAGSKGVPGTPRDGAAIEITGLLYSTLKWLASLNSEGKYQYSSVKKADDSSISLKDWAGLIRANFERCYYVPLTPEEDSKYDVNPKVINRRGIYKDLYKSGKEYEDYQLRANFPIAMCAAPELFDPEHALHALLVADKTIRGPTGMATLDPADLNYRPYYRNSEDSDDFATSKGRNYHQGPEWLWPTGFFLRALLKFDLARRGSEAGRIEAFQQVTRRLMGCKQMIRESVWAGLAELTQKDGEDCPDSCPTQAWSAGCLIDLYMDAAEEQSDKAKIALPVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYJ0</accession>
    <name>A0A1B7XYJ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dibenzothiophene desulfurization enzyme A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153356.1">
        <property type="nucleotide sequence ID" value="XM_018306515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYJ0"/>
    <dbReference type="GeneID" id="28870622"/>
    <dbReference type="KEGG" id="chig:CH63R_11541"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11541"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="485" mass="53615" checksum="8941DBE4E54859E7" modified="2016-11-02" version="1">MTDTTGSKPKKSLVLNAFVEMCSGHQSPGLWRHPDDQSWRFNEITHWVELAKLLEEAKFHGIFIADVLGGYDVYSQSLDPAKISGAQWPVNEPLAPIAAMAAVTKSIGFGVTVSTTYEQPYHLARRLSTVDHLSGGRYLDSAAKNMGLAQQPQPFDDNAWSLTTTKHDDRYAQAEEYIKVMYKLFESSWRDDAVKLDRKSGVYTQPELVRKIDHNGRFFTVPGPHIVQPSPQRTPLLLQAGTSKAGKQFAAQHAEAIFVSAHAPAVCAKNIAEIRQLARAEYGRDGNDIKVLALVTPILGATEEEAQAKLADYRQYASHEGALALFGGWTGIDLSKYGDDEELRQVESNAVKSTVEGYARFSPGTAKWTKHTIAEHVSIGGNGPIFVGTAAQVADGLEAWIEEADVDGFNFAYALFPQSFKDIIDLLLPELRRRGLFWDDYAVPGGTYRENFYRKKGQTGPLDEHVAASYRWKAGVPAEEAKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0F5</accession>
    <name>A0A1B7Y0F5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153988.1">
        <property type="nucleotide sequence ID" value="XM_018307147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0F5"/>
    <dbReference type="GeneID" id="28871254"/>
    <dbReference type="KEGG" id="chig:CH63R_12173"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12173"/>
    <dbReference type="OrthoDB" id="5056261at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="532" mass="59578" checksum="F802271EBBC9D8E5" modified="2016-11-02" version="1">MVATLRAEEGKNTKPPMWMRFLSSKNQSKQQLLTDRVGKGQGIPRSPVSLASKAVVRHTGTHGRKPAAGHFSPSVSTVQQSTVTISQTTVSGSGTHAAECEPLHGEQQKPIQSTQSTVIQMRETTVYTPEASPKDTHKELPPNPPPEDRRFSQPQPVSLQDAAAERSNYEMVLEDRMSFIEEQARTIEENRSTIEEHEKAIERQGNVIKERDKVIEDMNKIIGDMADDRSALLQRIADEKNRHADEVQELNQTLAVFRTKIINAADKSANIPAQAPLSRPESELLKDWGELAYDIRNLVANHYGGGLWENKIVSWAKINTEWLHEVTPNPLSAAADRKSGPALVEAAVWKALVRFVFGDTGGVAPMCWAGRYKGRLHRLTSSLQRNLEESGQHGALYQQWKALTVSIVSIIQPPHDHDEEVHSILDDLEEFFEPCRSRIKNSGAYRRELQAVVTKAIELDRKFSGQQACYAVSWPLQGGSRVAFDQKSMKVATGSPQSRNVEFMIQPCLWRSGEPGDFENFMVIDQCTVWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0T6</accession>
    <name>A0A1B7Y0T6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lovastatin nonaketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_09713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154111.1">
        <property type="nucleotide sequence ID" value="XM_018304687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28868794"/>
    <dbReference type="KEGG" id="chig:CH63R_09713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09713"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="290"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="290"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="443"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR05593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1447" mass="159722" checksum="D9B5640536718CB1" modified="2016-11-02" version="1">MLAVGFSYDQAQAFCSQPQFAGRIGVAASNAPASVTISDDADAIAEAKETLDGQGTFARPLRVDRAYHSNHTLEVLPFLRAYLEGCKITVGRPSARVASGSDDLDVVDSSSSNDSSSPVWISTLYGNDDLVSGDEIRCGYWLKSATDTVLFSQAVEASLVHGPLDLIMEIGPHAALRGPTIQTITAALGSSPPYTSVLKRGEDAIQAFSSSLGHVWENVGRPLDMVRLDLYQRTFRSGVHHGGDLGRDIDRIRPAMVVKGLPAYQWDQQRHWHESRMAANLRLRGGQPPNELLGRRCPYDSDSVMRWRNLLCLEELPWLQGHAFQGAAVFPMAGYAAVALEAALAMAGTRRKNTGPALLLDEILEMRVEDLVVHESLSLESCGKLETLVILTERKGTGTPSRARANEQHDTHEHDTLAADFTFEGCALTDGSKIPPELGRYCSARVVTSFVPDGHDDVDVDHVSSGESSSAYAIIAALYPAGSTRFESPILPVKMGRLVVSPRRVRDFARRCNTVRTGSSSGEEACGSVGTVSVAAYRGPRASPVACVSTQVLLDVDAESDHVVQKDRMVAFRTDDVAFRGVLGEQSASRHDVSLFYHNVTEPDVMSPNYELSPAQDDSALYYANIETLERLTMCYIRRIVEGVSVSQQASFPKWHHRHMTSVFRRRLLAHDEEQQHQYRQDKDYDDNFDAMLAQLEAQDVVNARLVRAVGENAPPGRVLLEQDGELSRLYDRGIAIADANRAVAQLIGLVAHRYPRMKFFEVGGGTGGTTKYVLEALAGRFRTYTFTDISAGFFARSEEKLSKYDDNCGHGGKIEYRVLDIERDPTSQGFTNGAYDLIMAANCVHATKSLGATLSHLRGLLRPGGFLVLFDITGDPIWLSYSFVFGGLDQWSAGASDDGRVDGPGVSRAKWDSELRKSGFSGLDQAVPFPRRREMFSVMLMTELDMPLFAHLSGDTLASFKLLLRSSRYFMVVTRRCRDENPDSNMLVGVLRALIAEMPHVRFQCIDIDDLDVRADNLDRTSGILSASLLRMVLAPLLEDEPSHEDDNNNNNNRILWSMEPELLVRDGCVQIPRVVKDKAKNDRLNSSTRLIKQETYNIYEMQHENVPSLSLFPDDVVLLAIFSSMILRRTGLLVTDDSKVLLLNPGRDLSNMSRENSCSDEWMQEVDDLGPWVLRYRHPIIPPVSESQSRSIFFCACADIANLDHSASTAYKDSTTPTSLFDWRSSIFTAQVQPLDFKALFRADRTYLLVGLSSDLGLSLCRWMVANGARHVAIASRHAPNQVRSSLHLSLAEDMRRAGAYFAAVHCDVTRRASLEAAVLELAEHLHMPPVAGIAHGAMVLQDKLFADMTVMDLEDVIAPKALGAANLDALFGGGGGGGDGEDREPAPLDFCHRNTLIHKKLPKSVILRITLRTNIYITNYILLSLLYIELSIFLPYSPIPYCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1R3</accession>
    <name>A0A1B7Y1R3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154472.1">
        <property type="nucleotide sequence ID" value="XM_018305048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1R3"/>
    <dbReference type="GeneID" id="28869155"/>
    <dbReference type="KEGG" id="chig:CH63R_10074"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10074"/>
    <dbReference type="OrthoDB" id="5413703at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="231"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="602" mass="66323" checksum="A36F50139645F904" modified="2016-11-02" version="1">MERPSGSDEETSLLAYGRAAEEHRWKDQKGGHGDGSLSGRQREQKRQGPDTTPAMEPFISGSRDSFGNLPPNVVEELKKMIKEEVAQASQVAQLKAYETETSINATRLSSLSSQNPVFTPPYPSPTSSVIEPLGMSKVSSSKDRIPGDATHVKAALAAQYQTPSLSPVSLPASQSISSISPEQKAVHFRSSGPPVIHCQPRVDSESESVSPTNPVAAPRVELSSVDKAWGILFDSEGYPTQRLNSVLRGLAIFMIAEFGPPETLVVTPDKMLALYSKYRIEPEKFEYEVIFRSRSDDALKRIEFLYQDLDCQYHLVQAAPRSHPHVPGLTPVGFAKWMISNILAYPDPEARRLHAVMSALPVNADGPLLDGKPERLPRQLSRHLFPESHDRKLRKILDEAVWDCLEDVAPPLPSIPRARPFEANTHTRRSGGESRRPAPVPYRKTYDRESYRVEPHPSRLLRANSDAGASLPRHRDLPPPPMGRHSDPPRQRSPSPTNRYSASLPTISQHHHHQAGSPSSSSQLTPAYIRGSEANYGVYPGRDGRDQGLRDESPRSPGLGRRGGTSLGSDRGPTWEDVYSRKESSSGGRVSSTDAASHRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y282</accession>
    <name>A0A1B7Y282_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial dicarboxylate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_10229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154627.1">
        <property type="nucleotide sequence ID" value="XM_018305203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y282"/>
    <dbReference type="GeneID" id="28869310"/>
    <dbReference type="KEGG" id="chig:CH63R_10229"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10229"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="185"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="285"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR06109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="41600" checksum="F9DAF9205FD904D9" modified="2016-11-02" version="1">MQSAAAANMIASKPADDAPSVSSSPSSPLQMGQGQEKPQSQLKQTATAATTTPNKKKIEPSLRYPFWFGGSASSMAACVTHPLDLGNALLPRETKDTQLPANPPARDHEDRTQPQNPVRLQVRRPDAPKNMSGTVAHILRNHGVTGLYNGLSASLLRQMTYSTVRFGAYEEMKIRATRANNGKAPAFPVLVAMASAAGFVGGISGNAADVLNVRMQQDAALPAAERRNYSHALEGMLRMAREEGLMSWFRGVLPNSMRAAAMTASQLASYDTFKGMLIRHTPMGDNLTTHFTASFLAGVMAATVTSPIDVIKTRVMSASTQEGLAHTLAKIYKAEGFGWMFKGWVPSFLRLGPQTICTFVFLEMHRKVYRKVADIGGSGEEASIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2Y6</accession>
    <name>A0A1B7Y2Y6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class-V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154896.1">
        <property type="nucleotide sequence ID" value="XM_018305472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2Y6"/>
    <dbReference type="GeneID" id="28869579"/>
    <dbReference type="KEGG" id="chig:CH63R_10498"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10498"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="212"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="528" mass="56927" checksum="BEE277426CC3DF39" modified="2016-11-02" version="1">MESIYANYPEYKSTARLDDLRATDYGYLDKQDHLYLDFTGAGLAAQSQLRAHESRLERTLLGNPHSENPTSRSATHLVEDARARILAHLGASPDEYTAVFTPNATGAARLVAEAYPWTRRSRLVLTADNHNSVNGLREFARRGHARTVYVPVRAPELRVDPADLVTALKPPRRITGSRLFGGGGGGGNGGKGHKSSSSNNSNSNNSSSGSRKNGLFAYPAQSNFSGVRHPLSWVSLAQQQGYDVLLDAAAYLPTSRLDLSPSSGARPEFVIVSWYKLFGYPTGVGCLVVRRDALARLAGSRPWFSGGTIAAASVGVPWHVMAPDEAAFEDGTVNFLSIPDVRFGLDWLDGIGMDLIGTRVRCLTGWCLDRLRALQHGDGSPVVRIYGPTDMTARGGTICFNFLDVGGRIVDERLVAAESSARNISLRTGCFCNPGAGEAAFGLSKRVLEPLSRAQMQMKMQVQVMNSGGGGGGSADDYIRLLAPVGAVRISFGFVTTTGDVDRFIAFAEETYRDRLAPVNGLPTHDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3B9</accession>
    <name>A0A1B7Y3B9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155012.1">
        <property type="nucleotide sequence ID" value="XM_018305588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3B9"/>
    <dbReference type="GeneID" id="28869695"/>
    <dbReference type="KEGG" id="chig:CH63R_10614"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10614"/>
    <dbReference type="OrthoDB" id="4845137at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="683"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="713"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="831" mass="93778" checksum="8E380CD827805DBE" modified="2016-11-02" version="1">MHVKTTMKSVCVPRRCGLCGFELQLGDNIVAVRRSDIKTSQPYKYSIVGFTDSVLGIDYAQCLGRCHHDEQRAGCHVDCIEITPDFTLAKVLEVTTPAFEPPVLADKRRIRWFQSRLAGILETTTRHLPHLPEEVRHNIAAWALDHRLTRRRLVIDCVNKRCAEKVSAVLSVKTSEKIYARHVEFEGVQYIAYLTNAASDDKDILLFDPTSPTSINSLFVANDHLGVRQLLFTDSSKQCTIEQEVGVWWRALKLESLGGRIQYHSDGLKLRDLKGEAMVLPKDCWGVPQLAPECVRFESIWNAEPSYHMSVESCNDPQTTAYSLCWNSQILMLHAHYVKENLDFYQSLRTTDETAIWQYMPLHADEVLTEIWKFNGPFRSAIGLLLVTNQGRSEFLGVQPRPNWSQSEWTLLDLPSDTTSRIYVETTTYGVRRLGFETPRPERRAQVPSFERPTSSYPIFRHGEYYAWNKAKLNEVVEIVPCRRHHRGRVITIGLLLHYTDGNSACVGQIRLDCLGEASSVDPASDGMTDDVELGMEVLRKSYKGMRSVNRLYNGIGGKVHIPRDHHRSPPSRERCSSPASATTASYGSTLAFETDPRLPESLPPYAEYLNEERSPRVRSDAAAAAIFAKSPAGGLAPPEYGNTEQPYDVLDMSPPAFCGEQDINTHATPKRKRSFAAVCSPGTTAKGASHPARIPPSTSLDSGDENNAARFLHLFELQRQQLEQQRQQLELQHEQIEHLQKNVGELQRWNKKLKGLHDELEADCLGLETLQDQANDAINNLPVEDLKANIGDTFKEDMCKLMKDSMAKQIVECVEAQADEVKRKIRQALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4G9</accession>
    <name>A0A1B7Y4G9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_08452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155449.1">
        <property type="nucleotide sequence ID" value="XM_018303426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4G9"/>
    <dbReference type="GeneID" id="28867533"/>
    <dbReference type="KEGG" id="chig:CH63R_08452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08452"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="535" mass="58745" checksum="68BEB2C90B880B5D" modified="2016-11-02" version="1">MGRPSHSTDTDATASRSSISTAKPPQELEGASTNTQTVSERAMNRRVNRKMDIALLPLLSLLYLFNGLDRGNVGNAQTQGFTNDIGAVPDDLNLAVSLFFITFILFQPPSAAIGRWLGGKHWIPVMMLGWGFVTLGQAFIKGRGGFPLLTCWFFIALTSPLLIFASLVAGSLIATRLLIGAFEAGFYPTAVAYLSFFYSRYDLAVRVGLFYGQYAVAGAFSGAISYGVFHLNHGPLKNWQYLFIIEGALTVLFGLVAWVLLPVGPGSAWFLTPAERRFAADRIRADNALFVEHTYDSDGLEKDRLTKRDFVETARDWKFWYVLAFNICASVPGQAFSVFLPLVVQGLGYSSIEANLMSVPPYVCGAVGLYCFTLSSDYHKERGYHILGGIMIALIGLIATVTVESHGGKYAALCVLLLGSYVAAPLTVAWLSGNTPEPGKRSLVLGLNGFGNISGIIGAQLYRAQYKPYYRIPFYATLGFVAAALVGYLSYRFTLAAVNRKKLEIIRHKSLEDIEKERVDGTRYADKKWTFIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y578</accession>
    <name>A0A1B7Y578_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155670.1">
        <property type="nucleotide sequence ID" value="XM_018303647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y578"/>
    <dbReference type="GeneID" id="28867754"/>
    <dbReference type="KEGG" id="chig:CH63R_08673"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08673"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="433" mass="41541" checksum="A61283EAD9514E62" modified="2016-11-02" version="1">MSSIVNKVKDALSSDKKHDQPEGTSGPHTNRAANAADPRIDSDRDHRANPAGTTGTHTGTHTGTTGSGLTGSHGTTGSGLTGSHGTTTGSGLTGSHGTHGTTGSGLTGSHGTTTGSGLTGSHGTTGSGLTGSHGNTTGSGLTGSHGTHGTTGYDDPDGVHGPHSGRAANKVDPRVDSDRDHRGAPGSGLTGSHGTTGSGLTGSHGTHTGTTGSGLTGSHGTTGSGLTGSHGNTTGSGLTGSHGTTGTHGTTGSGLTGSHGTTGTHGTTGSGLTGSHGTTGSHGTTGSGLTGSHGTTGSHNTHGNSSLTGNPSTGATGGVSNTHNAAGHVGSAVAGTHGTGPAPNTAGPHKSDALNKVDPRVDSDLDGSKTVGGNKTYAQDTTGVAKDPTDAAQVPPSVLAKHIGEPEIAHDDHSHGRARRNSKVSAQELHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5I7</accession>
    <name>A0A1B7Y5I7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155837.1">
        <property type="nucleotide sequence ID" value="XM_018303814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5I7"/>
    <dbReference type="GeneID" id="28867921"/>
    <dbReference type="KEGG" id="chig:CH63R_08840"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08840"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="338" mass="36334" checksum="134E1360B3BA9039" modified="2016-11-02" version="1">MASSSLPSKTLQVSPTITYKYYYSPASEPALQTLLFLHGFPSTAADFRPQLEHFASRGYGVLAPDLLGYGGTSKPADAREYVWRAMSAHVAAILDAEGLAGRAVVGVGHDLGSWFLSRLCHLLPPRLGLAGLVFLDVGYAPPGGRFDVEAINRVTADAATGDERFRYWDLFAGGPEAVALMDREAASVVSLMHAPPGVMAANLGPRGRAREWVSAGRVVAPAAAAAAGDAFATEAYLREKTAVFQEGGWTGPTNWYRALRDNLSLEDERDMEKGIRVPVMVVGCGRDEMTTAGLQDQMTRPWAGAGYRFEVLDTGHWVMLEDAAGTNRLLGEFLDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6P7</accession>
    <name>A0A1B7Y6P7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_09188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156185.1">
        <property type="nucleotide sequence ID" value="XM_018304162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6P7"/>
    <dbReference type="GeneID" id="28868269"/>
    <dbReference type="KEGG" id="chig:CH63R_09188"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09188"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="691" mass="77714" checksum="1D2E853320484454" modified="2016-11-02" version="1">MGLLALGTALDWPDAKQRAGQVREWGIKQLLEIWNKAKSKERDALLWGDEVEYLVVTYSKDDPKVRLSLRQAEILTALAESPDLAKEGGCVPDLQDVARGKSSVTLPVFHPEFGRFMLEATPGKPWGIGLKELLDVEPDMKLRRKIAKDHMHANEYPITLTTFPRIGCPGDFTEPYYPPSGPKLRSQFVPDEIANPHIRFPTLAANIRWRRGRKVQVNVPVFHDRNTPNPWRDPTVNYDLHNWPEDEDVRTGGAAPDNFIHMDAMAFGMGSCCLQITFQAKNITEGRKMYDQLSPLGPILLALTAATPVYKGFLANTDVRWNQISRAVDCRTPEELGEKPLKNDRWRIPKSRYASNSTYISTDPRLRPEYLSPDLVIDEDIKAKLMEGGMDDRLATHFAHLFIRDPIVVFEEDLQELDLGKTDHFENLQSTNWQHMRFKPPPADNSIGWRVEFRPMEIQLTDFENAAFSVFMVLVTRAILSFDLNFYIPIPRVDENMERAHAVDAVLAEKFFFRKNPFASRHRANNLGGDSESRPGSRPGSAHPSRPPTPFLPVEEEYAEMTVNEIINGSPDGDATGTGFPGLIPLVESYLDGVNVDVQTRCELDTYLRLISRRASGELDTAARWLRNFIDAHPAYRHDSVVGDDIQKDIIAAVIAIGERETAGEGFAGLDIHGLPRLLGNFRRGGCGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Q1</accession>
    <name>A0A1B7Y6Q1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_09166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156163.1">
        <property type="nucleotide sequence ID" value="XM_018304140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Q1"/>
    <dbReference type="GeneID" id="28868247"/>
    <dbReference type="KEGG" id="chig:CH63R_09166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09166"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601379" evidence="10">
        <location>
            <begin position="20"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="162"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="12">
        <location>
            <begin position="658"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR07645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="953" mass="102859" checksum="154D9719CD752AA5" modified="2016-11-02" version="1">MCLIRRLAAAVAYCSVAVAYQTVPKAYFIELSKNFSVDGIASSPDTFVQKASELSIPLRVRYKFLDQTVFYGLSVSLEHDDHVRTLRFVPGVENVVPVEQMTHPHRPSVGASQASKRETSPVESDIKQLRPRSSLPRDSEIDWNSPHAMTGVDRLHAQGIFGDGVRISIIDTGVDYLHPALGGCFGKGCKVEFGYDFVGDDYGSRNFTPNPSADPRPGCYAGFHGTHVAGVAGMDAPPNSSMFAGLVGVAPRATLGMYRVFGCDGTTSHDAIVAAMQKSVEAGADVVSISICELGTWSGYPLSPLSAAVAALKAKGVAVVAAAGNSGTRGMFSIKLPAGADDALGIAAVENSKFPTYPVQDSNGANFRYGSLYPFPKGVYSVVWADRDSDDYNFGCSASDYPPASQLSGPISNYIIAIKRGRPCSPTQIQSHAIAANYTRVITYPDPTINDVFVEGHAAPGPFLTADGSEFSMSSAIDDTLFNAAKSPGTYKLFVDSQKAYLVDQPGGGLPNMFSSIGQLRKPRSLRSQPDKVVISDSSTGPNADFAFKPQLAAPGGMILSTMPLMEKSRGYGFVSGTSMATPYVSGVYALIKSQLPSLSVDEIFARMQTTAKQVRMADFDLTAPAIQQGAGLVQAYEALFSRSAISPGEFKLVDGYEAAFTIVNPSDDDAIYTFSNIPAAGTVAFTESRSRSSEVEYIPRSFSANVQFVPGHRITVPAGSSLDVPFQVTPPFDIDPSRIPIFSGFIGIVSSFNETFTIPYMGPAYNYSNAPVVGLSNITEAQRSNALTPSRDPFSAPQVFAQGDKFDIGNYRSFSFRNSDYPVAYFTTLQPVQKFRFDIVRASTNFTPTWYGFDPDVRLDNLTETRMAENITVAGASILGSILVQDGWLPHTNYQASWSDSIMDVRAARELGLKKGSYRVLLRWLKFFKDEGDPDSWDTWLSGVVDVLEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y6Y5</accession>
    <name>A0A1B7Y6Y5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156216.1">
        <property type="nucleotide sequence ID" value="XM_018304193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y6Y5"/>
    <dbReference type="GeneID" id="28868300"/>
    <dbReference type="KEGG" id="chig:CH63R_09219"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09219"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="144" mass="15151" checksum="DC37178A1C5771A7" modified="2016-11-02" version="1">MRGVLPSHHWLQAEGWTWSEGNSLFIGRATTTSRPRLAPAPTPAPAPALQVASRFLLLTPTTDHQHPGPGPGPGPGPGPGPGPGSGHTYDEICRIRESKFTTFALARSVSDSLAPPPSVSPSFPTLALPVLQATVPYRIHPMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y728</accession>
    <name>A0A1B7Y728_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156327.1">
        <property type="nucleotide sequence ID" value="XM_018304304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y728"/>
    <dbReference type="GeneID" id="28868411"/>
    <dbReference type="KEGG" id="chig:CH63R_09330"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09330"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="615"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="678" mass="76234" checksum="D4659048043C9E5A" modified="2016-11-02" version="1">MVTHTMRAYRARKMAFLARSYSTAVAITDPLVKYRTLVSTKVLSPDPDQHRLAIHLQKLYGRLKDYAPEVDYRERLKQVADIPEARDPDEAAATLAMPSHPIWDNPLFKHLARKAMPVSKDQNPMALVRVMTSLEGAITINSPRGLFLSGEVGVGKSMLIDLLAQGLPTERKKRWHFNTFMLYTFSQLERFRQSHPELSGNEKEYSMLWLAKKLVEESPVLFLDEFQLPDRAASKILSHLFIAFFHLGGVLIASSNRMPEELQKAIGVEYTVAPSDGFLKSLFLGGARSRGTRHSQNDFAAFLEVLKARCDFWHMEGATDWRRRETGEKVTVETTSIKGNGAVEESAEAQEEMTKPAKYFLSPEASSWTTELSDLLSRSWTPATLTVYGRTIVIPRQRDGVVHWDFDDLVATFGPADYVTMASTYHTFIVDNVPTMTTLHKNEARRFITLLDALYEARCKLFVRAEAGPDDLFFPDIRAAQAEAVLAAAAAASRAETGEEVIDSDAIHSETIAEVYQDQAAPFRPNISYYDTELPTSKYDPDQDSDFGRLGNVSSATGASSPNFSNTAGFIGEDERFAYRRAASRLWELCSAAWHARGAGSEPADWWTPVPRTARHWEDSAPSRPKKDEPLLPRRQTDATMGPSRPIDEPFGTDKLVIDRWQALEEAERRRDESSQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y791</accession>
    <name>A0A1B7Y791_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156296.1">
        <property type="nucleotide sequence ID" value="XM_018304273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y791"/>
    <dbReference type="GeneID" id="28868380"/>
    <dbReference type="KEGG" id="chig:CH63R_09299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09299"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="31321" checksum="91D9D4453277F4AD" modified="2016-11-02" version="1">MENLLSLAFDGLSSYDGPKVRKGLRQVEGLLAQICLSSPAKTRSPTADDESTRRGAGGKSLADLSDDPAFREFFKLQEGFEWNVAMRLINTLDRLMGKGTDGQNDLLILNSLDLIQGVLLLHPPSKALFSREQNMNLLLDLLEPVNCPAIQSATLLTLVTALIDTPTNTRTFEALDGLLTVTSLFKSRSTAREVKLKLVEFLYFYLMPEVASVPRTSATALHQRSPSKLAASTTAADASHARNRAGSESADTLTTEEKQELLGRHLSNVEDLVRDLRTCTPFGGVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7G2</accession>
    <name>A0A1B7Y7G2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal L18p/L5e family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_09369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156366.1">
        <property type="nucleotide sequence ID" value="XM_018304343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7G2"/>
    <dbReference type="GeneID" id="28868450"/>
    <dbReference type="KEGG" id="chig:CH63R_09369"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09369"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR07848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="300" mass="34469" checksum="3E97A17C4640F7AF" modified="2016-11-02" version="1">MAFHKLVKNSAYYSRFQTKYKRRRSGKTDYYARKRLITQAKNKYGAPKYRLVVRFTNRDIIMQIVTSEITGDKVFAAAYSHELPAYGITHGLTNWAAAYATGLLIARRTLSKLGLDKTFTGVEEADGEYTLTEAAETDDGERRPFKANLDVGLHRTSTGARVFGAMKGASDGGILVPHSEKRFPGYDIETKELDAETLKNYIFGQHVAEYMETLADDDEERYKSQFQQYIDDDVEADGLEELYSEAHAAIREDPWKKPERSNTKSKEEWKAESKKYKTQRLTKEQKEQRVKERIAELRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7Q0</accession>
    <name>A0A1B7Y7Q0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CH63R_09469</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156466.1">
        <property type="nucleotide sequence ID" value="XM_018304443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7Q0"/>
    <dbReference type="GeneID" id="28868550"/>
    <dbReference type="KEGG" id="chig:CH63R_09469"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09469"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="199"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="405"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR07948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="588" mass="64698" checksum="F10EED2CB97F28AF" modified="2016-11-02" version="1">MAATKRSLADTEAEVDVTSKKQKVKDLPAGGDEAAAELKKQKKKEKKEKKEKKEKKDKSSAVAAADEESPAETKVETEEDKAERKRQKKEKKEKKRKEKEAESSNGAAADDVPVVTASGPTPTAAVLGGYQQAAALTALPQSEVNAFLTAENITVTDPVDNPTALRPILEFSYLPKTDLIKKNPFSAYKKPTPIQSSSWPYTLSRRDVIGVAETGSGKTMAFALPLVEGISKIKKRCIKAVVVSPTRELAMQTQEQMEHVSSLLGLKSICIYGGASKDEQRGLLRRGADVIVATPGRLKDFMMDGTISLGDVRFAVLDEADRMLDKGFEEDIKMILGDMPPREERQTVMFTATWPASVRKLAESFMVDPIKITIGSSGKETANGAVELQANTRITQRVEVVDPRAKEQRLLQLLKQWQTGAQKDDRILVFCLYKKEATRVETFLQQRGIRVGGIHGDLRQEQRTRSLEAFKAGTTPVLVATDVAARGLDIPEVKLVINVTFPLTIEDYVHRIGRTGRAGKTGEAITLFTEHDKAHSGSLINILKGAKQPVPDELFKFGTTVKKKAHSTYGAFFKDVDMTKKATKIVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7U7</accession>
    <name>A0A1B7Y7U7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cholera enterotoxin subunit A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_09588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156585.1">
        <property type="nucleotide sequence ID" value="XM_018304562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7U7"/>
    <dbReference type="GeneID" id="28868669"/>
    <dbReference type="KEGG" id="chig:CH63R_09588"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09588"/>
    <dbReference type="OrthoDB" id="4927890at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00771">
        <property type="entry name" value="ENTEROTOXINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601414" evidence="5">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR08067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="165" mass="18436" checksum="4B3B367BE4AB17C9" modified="2016-11-02" version="1">MSMQQNLFALFYLASLWFFLGEAASLQAGPKFVWRGAGRAPQDVKAAGGFLPKGLTAVGEVAPEISLWKHVDVPEEFDEDGNRVGLGSTEDDDGYTSFTSSFFLALGYAFYSRQQDTTWIYRVKTTPNMIDVAKTLGKHNIYSEEDEYAALGGVKWDQIVSWRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8N9</accession>
    <name>A0A1B7Y8N9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156924.1">
        <property type="nucleotide sequence ID" value="XM_018302146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8N9"/>
    <dbReference type="GeneID" id="28866253"/>
    <dbReference type="KEGG" id="chig:CH63R_07171"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07171"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="550" mass="62566" checksum="9DAA45BC8417C7F1" modified="2016-11-02" version="1">MAREHLYLVSSAVLGTYILWTAAESYVRWSRGSHLTSSHAHAHPVLALFLTLPTVILYNKAQYLLRMKARGCGEAPVFPHTDPVLGSDWVRTSLARQRDHGLLEWWQDLFAKLGYTWWVKTPTGWALMTSEPENLKAVLAASFDDFPITGPRREAVLPILGPEAIFSANGEVWHGARAMMRPTFVRDQIADLECFERHVGDLIANIPKDGGTVDLQALLYMMTMDSATDFMFGHSTNMLTTPSPEAREFTSMFEYITTRAAVRSRLGLLTFLDNDKKWHEGLKLIHRFCDNYVERVRAENEAGEKTQKKEKMEEAAAAGMETQDPKRGYVFLHEMMGRPGMTPEYVRAQLLSMILAGRDTTASTLSALFWILARRPDVVSRLRAEIEGLEGRRPTWEEMKDMKYLNMVLKEILRLYPTVATMSRGTARDTTLPVGGGPDGKSPVFVPKDTPVRWSLFCLHRRKDLYGEDADEFRPERWEERRPSWDYLPFSGGPRICIGQQFALTQMSYFVVRMLQTFGDMAPRDERPMLQTVGITTKLPNDVLLSFTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9I5</accession>
    <name>A0A1B7Y9I5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein efr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157168.1">
        <property type="nucleotide sequence ID" value="XM_018302390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9I5"/>
    <dbReference type="GeneID" id="28866497"/>
    <dbReference type="KEGG" id="chig:CH63R_07415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07415"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="938"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122480" checksum="A0EAD582A12F325E" modified="2016-11-02" version="1">MNAIQQKCRPKHQVLVLKCYPRTNKGAVDVKPNSSELSYLLFYATSRRSKIQKIGSFLEKKTASDVWRLRIGFVHSSQGPRGNVVSDPIPFRNVQVTLRILTALIEKAPKDLPLVAPNVLKILDLILGSKDITMVESSIPTFEAFCENHDASSSFADQAYLAQYESIVRTYASLASTRQNPGKGASSKPVLMRWRNAGLEAIRSVSSSEALSTVTGRQFDVIVPVILDNLWWDDDELLDTLLSRIQMEEKVQTEKLRRRTSTATVETGGTGGEANPIALTGTAFDVDKLAEEDIGVLAMQCLKQIFVVPNRPQIHSATGSLFQFIESRVTNGNTVVKTDEKSGKDHGWAISIYSAIARWAPVQDRYVILVTAMDHLLKAPVKDDNLSLHLALTAMIGSLLRSDVNLIGLSAMDVLLGLVQQMKKLIQLPGGFGRVEGEAEEAPSALQGAGDVFAQRRELLERIQICIGDLATHVYYADQISDMISTILLRLKPSKSSSTSSSPQVENAEQPSSDELSSSQPQLETILSRNVGKTAALKAIKNILLVANPRAQMSGNLNLSRNRVPIQVWENTHWLLRDPEGEVRKAYVDALLTWLDRETTAADSTARDESAQHYRSSLKNSRELQPANVAQRAASNASNREKPSRQRTHFLQLLHIAIYDNALQYVDYDPDIVLLHVLLTKLVAQLGVNAVQYGLPMVFRLQEDIPDAELPVQKVRLGSLCHGYFWAVTEKFDIENSAVGRAITNEVIRRRSKHFWTEGVAIPPPGLDFVGTPGVPKLQTKLPSTEVESEALLPFDDRASFVESIAVSYADTSASPPTSPPQSPGRNFSHPILSSSITTAPAVPGTGLPTAFREHMLTDWSRDAAMLALQTGSKSESLAGSKTGTMGTNRHHLTVNGANGHGQTGESSPLGSQRNLRPNSSQVPGGLSPMRQLRKSSVRSGVSPSPSDSSRGVVASVDQLKMVLTGQVPATPIGTSAGLHHDSDSDSMVSYEFTPSELSFNPAASQTENGDGASLGRQRSSSQSRKGGPLNSNPLYDHNENEEVPPVPPLPNHLGGLTSSISIQDYAVKPAKRNLSSRGGDSLYHGSTKGDGSFSMVSGGGMDLHELLNGIDSRAGELSLGNVTKPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9Y0</accession>
    <name>A0A1B7Y9Y0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hco3-transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_07433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157186.1">
        <property type="nucleotide sequence ID" value="XM_018302408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9Y0"/>
    <dbReference type="GeneID" id="28866515"/>
    <dbReference type="KEGG" id="chig:CH63R_07433"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07433"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="84"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="275"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="967" mass="106869" checksum="9C29D41FDD43113C" modified="2016-11-02" version="1">MTPNSTAAGPYDDREFPSATSPRSQSDVITPIRESHGLISDRVERRSSEKRDDHDGVSVGDAGPERRSGRWRGYFRRGGKLRPFRLLKEDFGNFRLRYYSDWTVFNQLVLASAVYVFFTNILPGITFASDLYVLTGESWGTIEVVFSTGLCGVIFSLFSAQPLTILGVTGPFSVLAENIYTLCENSFKVYGAQVTRFFITLTLFLPKIPFLPFMAWSLIHSGWMHYLLAIFNAHDYTMQYVTDFSADIFSLLNSVIYFYKAVRELQRTKAVVSLAAFLYSIIGAAGTCMLAIFLSTAVSWKPLFHRYVRMGLTEYAAAISIVFFIGMPYVGDLAQLDHNRLEVSKTFRPSSPSRDYFFVEFWKLSIGWIFIAIIPGIIITVLFYFDHEISSIICTAKRYGVQKPGGYAWDVMLLGTTTIMCGILGIPPANGLLPQAPLHSESLMYTVYEDPPTSDSGPGDDPPAKPVLRVYEQRYSHFIQAAGILLFISPPFQHVLGLTPTSVLAGLFMFMGYQSLSVNPILTRIWQLLTPISELPDLPHGASWMGIHFYTITQLVLTGIVFGVTLTVAAPGFPIIIIILVPVRLFFMNRVWSRQTLRYVDGWATREGKPEDDNNDRRRGGVVTSGAAARQAADADEEKGNKITAPAPNHSGKVVLPSVPFLQYAAGTVETRSYVAVCINLAFAKLLLERGCSVMIGDLALRPGASSLLAQYPHPRQPNRPSALFQPTNVASWPQLTQLWTKTLESFPQVDIVVPGAGIFEPSWSSFWRPPQTETNLQTKSRDAADAEPGTYAVLDVNLAHPIRLSQLAIGHWTQQKREGCLVHVGSIAGYAAGIGSPLYMASKHGLHGFVRCMGGMRDRLGIRCSAVAPGAVMTPMWLEDTEKQHVAQGEGSNLFIDSEEIARGMLELCENPEHGDGTILEVTKGATRVVPLYHAEPPGGKGAVIPRLVDEAEKIWGELESLGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAS6</accession>
    <name>A0A1B7YAS6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol-specific phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157646.1">
        <property type="nucleotide sequence ID" value="XM_018302868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAS6"/>
    <dbReference type="GeneID" id="28866975"/>
    <dbReference type="KEGG" id="chig:CH63R_07894"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07894"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="351" mass="39194" checksum="707920D677239724" modified="2016-11-02" version="1">MRFHCMPLLYVVAFFVLISGLFSVLLSLAPCFVKSKNHCYRGYESHYSFDVNRADHAEWMRAIPDDANLTSLSIPGTHDTMTYDLDNQVFQCQNHNLSAQLHAGMRYLDIRGRLVNDSIDIYHASMPTGHSYAEVLLTVFDFLDDHPSETVVMRLKEEGRPLGANTMTFEDAFNFYLHNSTVTSPGAKSHFRKHDPRKPYPTLGALRGKIFLLQNFPSKGPESPYGVVWASADMVLEDLWIIPSVEHLYMKWEAIENALRRAATAGDHVNRVLYLAHLSASVGVLPIEAAAGNLNRTVAGMNDRTGDWLAATADRGDSGKTGVVIIDFPGKELVDQVLARNRPLTDRGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB49</accession>
    <name>A0A1B7YB49_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZIP Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_08057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157809.1">
        <property type="nucleotide sequence ID" value="XM_018303031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB49"/>
    <dbReference type="GeneID" id="28867138"/>
    <dbReference type="KEGG" id="chig:CH63R_08057"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08057"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR09292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="423" mass="45948" checksum="FA2188B3D98E3C89" modified="2016-11-02" version="1">MAEVKEPKPQCGGGNKAGDEYDVGLHVAGLFLVLAFSIFGAGFPVMAKKVKWLKVPPKVFFACKHFGTGVLIATAFVHLLPTAFGNLMNPCLPDLFTDDYPPLPGAIMMASMFMLFTIEMWINAKIGGHSHGGPTGDVMHSHAHGPAPGAPPRPPRSGRDSFDAEADSIDFEKRVAQRAYDDEKSRFPAYGPQPANTLSDSDMPPWFVVFYEQYVRQRMEMMNMIRTTQEKQTSSQVAVTEVKQEEDPFYDAEGQQVDPAVYRKMSLNITMLEGGILFHSVFVGMTISITIDGFIILLVAILFHQMFEGLGLGSRIAAVPYPKGSIRPWVLVVAFGTTAPIGQAIGLLTRSSYDPESAFGLIIVGVFNAISSGLLLYAALVDLLAEDFLSEEANRLLSSKDKITAFCYVLAGAAGMSVVGIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCW0</accession>
    <name>A0A1B7YCW0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_05569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158394.1">
        <property type="nucleotide sequence ID" value="XM_018300544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCW0"/>
    <dbReference type="GeneID" id="28864651"/>
    <dbReference type="KEGG" id="chig:CH63R_05569"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05569"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="40566" checksum="2655B596D6697673" modified="2016-11-02" version="1">MMLLVIRTAQQVAESTTIYDHNYDPFYQQPSTSETESTYMSAATFNVGRPSNDDTITHFSGANPLLDAMAVTTTGWPYGAQPVSAAPDAMDDNMFQHSPLSDFLEMPDESDDWAILMQQDMLVTGAFEMAGFDFPTTMMEETNYQTPDSPEDIFNDPTVQFDIEQSLQTTGLFDFNGLLPDLSASGYLSGTDQVSSYFGSTNTSPYEPALDFFPEVAPSPSSIFPASADGSPLGTTTTTTTTSPDSDSAAAHPYRCTTDGCPKTFRKEAQLKQHQRVHRKALVCDICRAERRTEHKFAQVRDLERHLQARHRDVAERANVRSEVRQCPHPGCEHEGRRDNVSRHHRSKHGKELKWKRGVPHVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDC4</accession>
    <name>A0A1B7YDC4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158544.1">
        <property type="nucleotide sequence ID" value="XM_018300694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDC4"/>
    <dbReference type="GeneID" id="28864801"/>
    <dbReference type="KEGG" id="chig:CH63R_05719"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05719"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="262" mass="29304" checksum="1C62DC9249182D3F" modified="2016-11-02" version="1">MSSPSSPSPDNMSSEEFQQLAASYEPLIESISVSKGAKAGQKTLQELDQFRFVEAPALFSQDAPRRTMDHDDVKLLVDWKLRHGKFRPTLMKFVLSNDSSTVQATTIEAIENYRDAADLSAALNILTKLKGIGPATASLLLAVHYPEKIIFFSDEAYYWLCNKGQKASLKYNMKEYESLNAEARKLMKRLDVSATDIEKVAYVLFKQVGSLPKQASNDYVSKSATIEFTKPQQPAPAKRKKTSEEVVENKGPLRRSKRGKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDP3</accession>
    <name>A0A1B7YDP3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_05824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158649.1">
        <property type="nucleotide sequence ID" value="XM_018300799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDP3"/>
    <dbReference type="GeneID" id="28864906"/>
    <dbReference type="KEGG" id="chig:CH63R_05824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05824"/>
    <dbReference type="OrthoDB" id="5425547at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601566" evidence="3">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="4">
        <location>
            <begin position="174"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR10132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="32859" checksum="9D290251F5647C77" modified="2016-11-02" version="1">MRLDIAVVALTLFAPAWAAAIDSGVHGSNVAVLAPKAERDNSKQDEKLWKRKGGGGGGGGRGGGSSGGSRSGGGSRTGGSSGGSRSGGSSSGSGSGSSSSQGGSGSGSSSGGSRSSGSGGGSRYGFPGHSQSGSSGNRQTNGASSTSRGGSRDNAGGATRTGSGPAPAYGGGKYYGGGATVPYRAGASRGSMVPFFLVGGAALAFWPGLWLAGAHMYPYSHPYRYYNQTARENQTKAVLCGCAEDLPCGCEENNATDYMNSLLGNGSYDGLNKSVVNIGLVNGTETILINGTLPYGTTAAGGDEEVGSAAFRNAVEALGFWPVAAVVLATVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YDR5</accession>
    <name>A0A1B7YDR5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_05680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158505.1">
        <property type="nucleotide sequence ID" value="XM_018300655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YDR5"/>
    <dbReference type="GeneID" id="28864762"/>
    <dbReference type="KEGG" id="chig:CH63R_05680"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05680"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="75" mass="8034" checksum="D6294C1707B17B88" modified="2016-11-02" version="1">MSSKPIVDHDDALFSNPDLLRLYLVPGALIASACIGYNSSVMNGIQGSSKILVSYYLAPVLRSIGITLINVIIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEE0</accession>
    <name>A0A1B7YEE0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159028.1">
        <property type="nucleotide sequence ID" value="XM_018301178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEE0"/>
    <dbReference type="GeneID" id="28865285"/>
    <dbReference type="KEGG" id="chig:CH63R_06203"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06203"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="119" mass="13804" checksum="51A09D0DD1F61E32" modified="2016-11-02" version="1">MTAHKFKFIVKEEINRVDVKFFAQVAKLLDEHGLGDVFGIRDLKNYNTDLNVEVTENNANLMLPCGSIDEDRLIITVWKLGLQEDDSCNCMSYCFKEDNKHLWCTFQALSNTYKCEDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEK8</accession>
    <name>A0A1B7YEK8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Het domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158976.1">
        <property type="nucleotide sequence ID" value="XM_018301126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEK8"/>
    <dbReference type="GeneID" id="28865233"/>
    <dbReference type="KEGG" id="chig:CH63R_06151"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06151"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="44157" checksum="4E0691E233252129" modified="2016-11-02" version="1">MERDMLFPIRDSRSIRILVLHAGDSSESLQGELELITIGTGRRKYEAVSYVWGSLSKTHEMICDGGPVSITESLHGALKRLRFPHKSRHLWIDQVCINQDDPEEKSSQIPLMDAMYRNATRVLFTRAWAVQEIGTKAPSTLFWGDAQVEWALLHSVCESLTDYHHLRKHVDIQTPIVKYMYRRFIEPDRSSRHANRFGFVYELHRARHLLASDPRDKAFAMLGHYSIRNGPNRQLRDLKPNYTKKLEDIYMDAASRSLVGDSSSLLTLAAVQHDSIPSGHGAVSLTSLDYSSMASPNKLPSWVPDWRIYQSHILSEPTSPHRAGGGRAARLSKWIRHPKRYTSREPSSIPWLRARVPSPPPPRVPRQWIRMVHGGREDLACRLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YF19</accession>
    <name>A0A1B7YF19_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_06385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159210.1">
        <property type="nucleotide sequence ID" value="XM_018301360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YF19"/>
    <dbReference type="GeneID" id="28865467"/>
    <dbReference type="KEGG" id="chig:CH63R_06385"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06385"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="394" mass="43308" checksum="03E712A05562E4CB" modified="2016-11-02" version="1">MDATIPPEVYGDDKRTTVVGSVVFCILFTTVMVGLRIYTRTKIIRSYGVDDYLAVAALLATTGCGIAIALMTTHGLGRHIVLLTPADITEYMKSFYTSIVFYNIALLCIKLSFLCQFYRVMAVPRMRRVYAIALLIVGAWSTSQLFISALQCIPVSGFWDKGVKAKCIPNQPQWYINAAGNIITDVAVFALPMPIFWHLSLPRKQKILLIGIFSLGFFTVAISIVRIRFLNIPADFTWANVDASLWSIGEISSAVTCACLPTLRPLLTKLFPGLMSRVNLSSAPSHQTETRRGLPTRAYSSLPKPRNLEKGTADWGTSGVKSSHLGDDDASIASDPPYQHHANESGETIFGLASVREETVAHMKSNFSPLSSPPMWNLSSSSQSSQVRREGTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YFH6</accession>
    <name>A0A1B7YFH6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_06382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159207.1">
        <property type="nucleotide sequence ID" value="XM_018301357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YFH6"/>
    <dbReference type="GeneID" id="28865464"/>
    <dbReference type="KEGG" id="chig:CH63R_06382"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06382"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7351" checksum="160CA891C9A7A141" modified="2016-11-02" version="1">MTDTFLAFSNRLKLGLRWVHSKMTRIDCRSKRSPWSTVESSMASQASYDVQPGVRAESGSYIIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHC3</accession>
    <name>A0A1B7YHC3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_03752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159973.1">
        <property type="nucleotide sequence ID" value="XM_018298727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHC3"/>
    <dbReference type="GeneID" id="28862834"/>
    <dbReference type="KEGG" id="chig:CH63R_03752"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03752"/>
    <dbReference type="OrthoDB" id="4831490at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601696" evidence="2">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="185" mass="20624" checksum="977351932F8B087B" modified="2016-11-02" version="1">MASRNLLAIAAVSVVLFLNLVLANPLPLFDHTSGARTLRSREDDLPYSGYMQLTIPPADTTKTQVSTTAGGGGLEAFAVLNEGGSILLVVYVERDYVSDDFNGLSGYRITVQCHESTIHFEQYHDLLYHDRRSLWARVSARQLDEWREEYETNEDSDIDITIWWEKDSVNDDDESSQSGDGSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIM2</accession>
    <name>A0A1B7YIM2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_04233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160454.1">
        <property type="nucleotide sequence ID" value="XM_018299208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIM2"/>
    <dbReference type="GeneID" id="28863315"/>
    <dbReference type="KEGG" id="chig:CH63R_04233"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04233"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="101" mass="11438" checksum="C00C71BE1560380B" modified="2016-11-02" version="1">MNGKVWWTVQEVEQPGLPRGESTFDLCSSKDSILEVLGLVVLKGSHVIEEGTEDKELWVILTSLNGIECWSVHTMYDCLSVYPKRMTEWKRSSLSRPGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJ54</accession>
    <name>A0A1B7YJ54_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160628.1">
        <property type="nucleotide sequence ID" value="XM_018299382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJ54"/>
    <dbReference type="GeneID" id="28863489"/>
    <dbReference type="KEGG" id="chig:CH63R_04407"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04407"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="338"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="45563" checksum="770F85DED61E1BF4" modified="2016-11-02" version="1">MASGEDQVPLNPELSSRQVVQQERELQRKAAKKEKKQLKAQAKRDRKANVSSVAKWDLTRKQADTARKAERRGEKDEKRFNRMLKHAEKLEAQAKKFMVEASRTREKHAIMAKKRAKDATEEEPELKIYDDESDSDSSSSSSSLSGSDSEVESEQGGAPVEVKDVEIKSESPNPSAQLRTESEARAASDEQRVESDDEEKPKKSKKSKKMEEEVEEATVTKKGKKEKKNKSKVEEPAAVKHEETVPAGETPTKKEKKDKKKSKKPKAVKEAEKEGQVTSNRSDKKRKRSADEDDESEGGAAIADETPSKKAKDKKKKKHKREEGEEETPAANAAVEQWDVEHLQGGMDRQQKFMRLLGGGKKGAAAAGAPTAGGSKGKRDIGKITQELEKQFQAGVQMKYEGGGQRRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJF9</accession>
    <name>A0A1B7YJF9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exo-alpha-sialidase neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_04274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160495.1">
        <property type="nucleotide sequence ID" value="XM_018299249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJF9"/>
    <dbReference type="GeneID" id="28863356"/>
    <dbReference type="KEGG" id="chig:CH63R_04274"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04274"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601721" evidence="3">
        <location>
            <begin position="27"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="563" mass="60200" checksum="80D75C4A042C5316" modified="2016-11-02" version="1">MRHFAIAVPSLWHLLLVFLLVEAVCSLEVTPGSDCAALCLGGPNGTAIDTATSGTNSSDIVCENDQYHSTGKGIKFRNCVSCMQKSQAAQGSQSDAAWFLYNIRYTVDVCLFDFPEAISNINSPCIINSACRPLKNALTAGLTTPDADTAYDYCTADADRFASPNWWSCVRCLQSSDSQSYLSNFLIALKAGCQQKPANGSLLGLTGQLFSTEAVNITESATNTTMPGDGGASATTMTLGTIVGIAVGGGLVFVGAICLFIIYCRKQRKQRMQDEAGLPPRLPRSHASSVTAINKSPYAPITDHKKSSSVNSYNYELQEKQNFSSNADYYDRLEQDVQVGREAAHYNFDPHSGFHGPSSALPTHPAYIPRAMSRQSNRANTPSPPNPRRTNTPESYALQTYLTAGEDPGTGGIRPPPQAAVASSSSTSRTPSPARSHGSRGDGANAQPKLVNIPPPPPGGPPPTHKKSRIPSLLLPSVPRIRVPKQYPPPQIIVEGATPVAGRGEAGGDMHISQPLTFHGQRFQDRPLAGHAIISQVAVAREVDPREYEGDMPIRSGKSTLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJY0</accession>
    <name>A0A1B7YJY0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyphosphonoenolpyruvate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_04675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160896.1">
        <property type="nucleotide sequence ID" value="XM_018299650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJY0"/>
    <dbReference type="GeneID" id="28863757"/>
    <dbReference type="KEGG" id="chig:CH63R_04675"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04675"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="306" mass="32281" checksum="2A13043EB47DCF11" modified="2016-11-02" version="1">MSSSGNTSTPVPAATKLRRRLEETDDLILLPGVYDGFSARIALDVGFDGLYMTGAGTSASKLGLPDLGFATLDDMRSHAEMLANLDPSVPLVADADTGYGGPNMVARTVTQYARSGVAGLHIEDQVQTKRCGHLTGKQVVDVDTFVSRIRAATLARQKIGSDIVVIARSDAIQTHGFDEAMRRLKAAVAAGADVAFLEGVTSAEEARRACEALKPTPVLLNMVEHGATPSWTAAEAKALGYRMMIVPFAAIAPAYGAIRESLVKLKETGEVGTKSDFSPRKLFSIVGLQEAMDFDAAAGGSSYSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPP1</accession>
    <name>A0A1B7YPP1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_02742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162533.1">
        <property type="nucleotide sequence ID" value="XM_018297717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPP1"/>
    <dbReference type="GeneID" id="28861824"/>
    <dbReference type="KEGG" id="chig:CH63R_02742"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02742"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="516" mass="58621" checksum="6625F77AD3310E1F" modified="2016-11-02" version="1">MLMALKGRRLALLAAFVIVSALLIFSQSLYPENLNWSDISASLPAGGKSSVPSTKASKTASAGIGRFHFLIAASAPNLQFCRALVSSTVNRFGAPVVAGWNGTGENDAALSHLAKIRVVTKYLEELPDSSNNDLFLMIDGYDVLLQFGPDVLINRYFEASAREDERIMQQLGPEMAEKLAGPLGRHIFFGADKVCWPVDWRRPACWAVPPVPNMDGREFGPLTNTEDMAFNHPRWLNSGTIMGPIKEVREMFRATLDLINEVYDPEYEFRESDQFYLSDVWGLQELERIQMQKEENPEAVVMQPPEDGWVPNLEPAYSYNFHIAMDYWSLMFQTWAGYAEWVDWRKFIGPLYSVEVTQNHRNNSDFVPWSLHMQADGMRSLKRIFNSTSDETMGATVNELIRKSEFGANIVTKQTFPLLHVTGEKGALDAFWPRLWFFPYGRSLIRSAINWFQAEEHYGPELIDNRVWYPAHPYPKDIRESDGGAWSDASNDNATVYWLGFDELCAEHHSILFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQG1</accession>
    <name>A0A1B7YQG1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_03012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162803.1">
        <property type="nucleotide sequence ID" value="XM_018297987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQG1"/>
    <dbReference type="GeneID" id="28862094"/>
    <dbReference type="KEGG" id="chig:CH63R_03012"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03012"/>
    <dbReference type="OrthoDB" id="4777753at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="321" mass="35812" checksum="85C087ECAEBED0FD" modified="2016-11-02" version="1">MVGSIDNYAVKMTKAGAKGRHYDFTNRRTVPPWHGIVRMTRAYQKKLQIKFGPVFEDRHVRFNAKNTCAKCGHIGHWLSDCAFPDDSGFLYGCPIHNSRSHSFDDCPDFHRLSESQVLWLLVVLRGNKAPIRTTVSWSEYLRIAIEEGKWTSYNVPLPLTSAFVLDLVLGPKARHSWLDFDYATHGNDWLPSDPATRGPHAEVVRNTALDKEVHVPLTRGSLKKGRVGAAVGSDAPSYADDGYAPQEDNNQEEDSRETPEAEAGGDVEMMNDPRVEGGNPFVPEVDKPDAFVHNMVTMGHADDASNDSRVQDMSEADICIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRN4</accession>
    <name>A0A1B7YRN4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163131.1">
        <property type="nucleotide sequence ID" value="XM_018298315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRN4"/>
    <dbReference type="GeneID" id="28862422"/>
    <dbReference type="KEGG" id="chig:CH63R_03340"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03340"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="46"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="422" mass="45264" checksum="4486FD6CA26B33D0" modified="2016-11-02" version="1">MDPAQLPPWDLPEGVTSRYVDTSPAGLKFHVLESLPDTLAPGQRPPLILLLHGFPNLSYDWRFVMPKLAAAGYYAAAFDMRGFGRTHNADLSPVPESSIRPMTALRDVVTLVHALGYEVIHTLVGHDLGAFVASVCAIARADMVKSLVLMSHPFKGSPRLPFGTAVSPRLAHKDAPSRTGGGKGDAARADPDIQTSLLKLDPPRKHYKYYNASPEAAGEWTYPTGEPLHRFLRGYFHLKSADYALNKPRALRSWTAEELAVLPHYYVMRADLSMRGNVELDMASSGPSDSGSDGRGGGGGGGGGGETAWLSDADLQVYTDAFSRTTFGPPLSWYKVLVDAALSADLACFAGTRLAVPTKYVSGTSDWGTHQVPGALEAMEGGESVRGDCWRGAVHVPGAGHWVNMEKPGESAREILELAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRR8</accession>
    <name>A0A1B7YRR8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_03452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163243.1">
        <property type="nucleotide sequence ID" value="XM_018298427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRR8"/>
    <dbReference type="GeneID" id="28862534"/>
    <dbReference type="KEGG" id="chig:CH63R_03452"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03452"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="288" mass="31869" checksum="3CDFBCD792AA061B" modified="2016-11-02" version="1">MSPNKYTLATRLTLANGKTIPQIQLGLYMMSGREVTKSVPWALAAGYRGFDCAQMYHNEREAGKAIRDFLASGENAQGLTREDLFYTTKLASSSASYDAVRRSIKQSVDVSGLGYVDLFLLHSPYGGKEARLTSWRAVEDAIDAGEVCMGGVSNYGVAHIEELVASKPRIAPVINQIEVHPFNTQTHIRETCAKHGIAIEAYAPLARGMRMKHPKILELAKKYGCTPAQLFVRWSLDHNMITLPKSVRQERLIENANVSGFEISKEDLAAMDALDEHLVTDWDPTEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTM7</accession>
    <name>A0A1B7YTM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_00580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163917.1">
        <property type="nucleotide sequence ID" value="XM_018295555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTM7"/>
    <dbReference type="GeneID" id="28859662"/>
    <dbReference type="KEGG" id="chig:CH63R_00580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00580"/>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="449" mass="47948" checksum="C8CAC62B2E9DD90A" modified="2016-11-02" version="1">MDGQQRDERAGQQSMQNGRVSVNGAQLAVGPRRRNDGQSPEGHHYLRDIGEKLTRKFPESWVEISSQPSSSSLSSIGDDIVTTGLRVGGSMAARRRRLHHQSQPVPRSFHVDQTAIHAGTSSQEEYEESESEEDRCLTSSTENVQPFLRASFQQQQRPRGESEDSDDSDEIATALGRVPDDPVFRPQPNAFSHPPSGLNRSHSANSAIHQHPHSGVRPALSQRSQTRVQRGPPNFMSPAYQADNDAALRASLTTLLSCAAAARGLPKYKDTERPGVPSAHAGVGPSSQPVELRLMPESELMTEKHTQTQGAPSAKSPVARPRTTTTSSASSSPRSDGVDKHKRTPSQTRSSRAAKKKKVAASDDALISPTLLTWVVSAGVVVLVSVVGFGAGYVIGREVGRQEALSAGVGVNASTVADSSSCGREVIRSSGGGLRRLRWGAGVGRSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUM7</accession>
    <name>A0A1B7YUM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164179.1">
        <property type="nucleotide sequence ID" value="XM_018295817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUM7"/>
    <dbReference type="GeneID" id="28859924"/>
    <dbReference type="KEGG" id="chig:CH63R_00842"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00842"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="228" mass="24768" checksum="689DD6FE5F0EF553" modified="2016-11-02" version="1">MVLSQAPVPLPVSLPRSPSLPVPLGPSEAFSDAPLQLLPLDSPITAFPSNRPVCNHGLTICSPRARPKSPDLLVRTVPEPAAHASLTQHSAAPPRSTQQVHPSYIHPPRGYLIRPELPSSTPIATRKLPSAFYPEQVKPRRASSTNPKERAYPQLQQGDQEAPCAGRRYPLLGLEVGHSCGTRKRSHPLPAFFPVSVPTLLGQGHHTGHPRKIRHSLKSRQGLPGDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUQ7</accession>
    <name>A0A1B7YUQ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164209.1">
        <property type="nucleotide sequence ID" value="XM_018295847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUQ7"/>
    <dbReference type="GeneID" id="28859954"/>
    <dbReference type="KEGG" id="chig:CH63R_00872"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00872"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="134" mass="14890" checksum="98DBF7C7E2BA10AB" modified="2016-11-02" version="1">MARNLPLVLHPSPPTSNQSPLAHPNVTRREGRKTARTYRQSTYSTQKRVNSPPNSFLKQNKKRTPGPGYSHSIGPLTIGSNQSPITKLDLSVPAFFKHLIDKRVLCAVRVSTKNLAPARGKRGKTDRRSLRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWH7</accession>
    <name>A0A1B7YWH7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dehydrogenase FUB6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Fusaric acid biosynthesis protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_01585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164922.1">
        <property type="nucleotide sequence ID" value="XM_018296560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWH7"/>
    <dbReference type="GeneID" id="28860667"/>
    <dbReference type="KEGG" id="chig:CH63R_01585"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01585"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00083301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="348" mass="38075" checksum="B8B0A5BCB7E86253" modified="2016-11-02" version="1">MAQQNLSIVLAERPTAEIIPGQTFKSEQKPIPKAEDLKDGQILIENWYLSLDPAMRGWLNDRRSYIPPVQIGEVMRGATVGRVLASKSPKAKEGDVLPTFGGWSEYSVVDDARVEPVSSFPNVSQPVDYLSGIGMTALTAYFGMLRVGDPQPGETVVVSGAAGATGSVAGQIAKLKGARVVGLAGSDDKCRWLTEELGFDVALNYKDPEFRQKFKEATPDFINVYFDNVGGEILDLALARAKEFSRFVMCGGISQYNSATPQGPKNYANIITMRIKMQGFIVFDYAKEYAQARKELAQWLDEGKIKRKETIVKGGLKAAEQALVDLYKGINTGKLIVEIKNPKDAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YX38</accession>
    <name>A0A1B7YX38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin containing amine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_01702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165039.1">
        <property type="nucleotide sequence ID" value="XM_018296677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YX38"/>
    <dbReference type="GeneID" id="28860784"/>
    <dbReference type="KEGG" id="chig:CH63R_01702"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01702"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="264"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="743" mass="82865" checksum="A448567C0805496E" modified="2016-11-02" version="1">MKQYTENEVQQALEDVAGGCSIRRAALTWGIPYPTLRHRIQGTQSRDIAFAGQQKLSQTQESLLSDWITTQAALGFSPTHQQLRELARRVLGDPQPLGRKWDIPGSQGSSSQSAGNIGSSQQWESAVSEVLWSTPRKSADLQHQLQLFSQLRQESQSVYTQRHLFRKIQKGWDNQAYRLAFVEHQNEALQAHINSQQQGRRKKVQLDPNTKFANIGDIQRAQIEAGEREDDADESSGSELPSEPESCVWLGQRSILTDCHHVRGPNWIHGTEENPVLQISQEVGVSLCAVDDTMQIFEPSGISMPKALADEELETVWSLIDEAFKYSNEECLDIRSDLSLKDFFKKKLSASSLSHDQQARVLLLAEMWGSFIGDSWERQSLRWFWLEECLEGENLYVMESHGPIVQHVAATALEHADIHLSTRVRSIENLRSDMEDPVVLVRTDDAVFKFDEVVVAVPLGCLKKDHITFVPPLPQRLQTAVGNASYSSLEKVYITFPVAFWDRIQASSNVPVSNQCSTVEGNEAQREKTGITSPSFFHFLHPEYVPEKQQHWSIELVPLSSAAVFGSHAKPTVLIYTHDPCAAYVSSLIRDLDPAGTKYFDALECFFRPFYSRLPNYQTGHADCTPTAILATDWHGDDLAGNGSYTNFQVSEAVTVTARNGGMYEEGQEKQESREIHLDLDIRVMRSGLPERGVWFAGEHTAPFVALGTTTGAYWSGESAASRILAANGIVSGTGATPSDDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVW8</accession>
    <name>H1UVW8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04566</name>
        <name evidence="3" type="ORF">CH63R_01934</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000328">
        <property type="protein sequence ID" value="CCF32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161725.1">
        <property type="nucleotide sequence ID" value="XM_018296909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVW8"/>
    <dbReference type="GeneID" id="28861016"/>
    <dbReference type="KEGG" id="chig:CH63R_01934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01934"/>
    <dbReference type="eggNOG" id="ENOG502TFE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552076_0_0_1"/>
    <dbReference type="OrthoDB" id="4844977at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="24"/>
            <end position="79"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="102"/>
            <end position="160"/>
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            <begin position="311"/>
            <end position="388"/>
        </location>
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        <location>
            <begin position="413"/>
            <end position="494"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
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            <begin position="330"/>
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        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR13208.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="494" mass="51959" checksum="66BFE2D5AB53EA06" modified="2012-03-21" version="1">MSWNGSIPYKIPYTGVAGTANFVPGAAAHPPAPQDTDAQGTTQQPVVAGEPVAASTSRSKGKKVATNATASPPQDPVPARFASAGAAAASGGIAIVPGGLGAGSPSSSEIAAVSGQGQMSGRQNGRNQGSQTSQPNTNRLPFGIDGQGDEGMPLSPTTMTMSAQRRADRALPVVAQELVAARAENQRLRDCNQALRSSSSEMPMLRQIINSLQNTNYQLHTQARSLFTQMSSIQQQAQAFAQQRQVLQTQLGDSIATLNELTSLVIHLQCVIRNINPDIFVMFPEDIQGLLTDIHEEWKWQEYCRMMLEEEMGSTSQSSGSSTIQTQNSHQGQTESQASYSGSANVASNESAIGSSTNSDTLASDNASAGSSNRNIDSTAGPSTEPAVSWDDTFADYLDEEFLAQLFTGHTLNAPSNNVSSRPQQPLTPETPSSIGTPRTIYSSAASETVQQAQAGHGSQTSEAAQDAESSETVEDITALDTIDAHNTATTPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UVZ5</accession>
    <name>H1UVZ5_COLHI</name>
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        <submittedName>
            <fullName evidence="8">Serine proteinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_00762</name>
        <name evidence="9" type="ORF">CH63R_11797</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000335">
        <property type="protein sequence ID" value="CCF32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153612.1">
        <property type="nucleotide sequence ID" value="XM_018306771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UVZ5"/>
    <dbReference type="STRING" id="759273.H1UVZ5"/>
    <dbReference type="GeneID" id="28870878"/>
    <dbReference type="KEGG" id="chig:CH63R_11797"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11797"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017824_2_0_1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="163"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="442" mass="48178" checksum="9D18C482C9841B2B" modified="2012-03-21" version="1">MASESEVAGSSTGSNNDDPSNRDESSRATRATPASAVDAKYIIWARKGTLKEDADGFHNTLVGIVGNKDEVEFLVNKKNIPYAWLAALTAAQLDKVRADGVVDRVEADVQLRTERPGDTAATRKRDNVQRRPSDDKPIIDLRMLSTPPQTPLLDYYAYDDSAGEGITIYMIDSGPFNFEHSELQPLDSSITRDNIDVMDSPGLIDDNSYHGTCVVSKAVGNKVGVARRANLITIRIDITPGKFRFIKAWETIRDDIKSKGLHGKAVVSSSAVFVATNDLEYNRKTLFDLQDLVQSITEMDVPVICPAGNSADKPKGSIEPNTLPAVLAERLPIIVVGSAAVSGTMSRFSQRGKLLTTWAVGEEIQCADRSSESGLLTTEGTSVAAPQIAGLAAYFMSHPKFRLQLRPGTVAKDMQSLIRRYAHPRARAFHYPGLAWNGFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1UW01</accession>
    <name>H1UW01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoglucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_04591</name>
        <name evidence="4" type="ORF">CH63R_11534</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000337">
        <property type="protein sequence ID" value="CCF32152.1"/>
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        <property type="protein sequence ID" value="OBR04831.1"/>
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        <property type="nucleotide sequence ID" value="XM_018306508.1"/>
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    <dbReference type="AlphaFoldDB" id="H1UW01"/>
    <dbReference type="STRING" id="759273.H1UW01"/>
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    <dbReference type="KEGG" id="chig:CH63R_11534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11534"/>
    <dbReference type="eggNOG" id="ENOG502SHG3">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_032571_1_0_1"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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    <feature type="chain" id="PRO_5010497513" evidence="2">
        <location>
            <begin position="22"/>
            <end position="431"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
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        <location>
            <begin position="355"/>
            <end position="376"/>
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    </feature>
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        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="311"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF32152.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR04831.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="431" mass="44103" checksum="5E38FDA9072B1AA3" modified="2012-03-21" version="1">MALKTNQLLFLASVLASTTLGHVVLENPKPFKFVADGPTNPISTSGSDFPCKIPPGASYEIDGSSTVIAVGETFEATFKGQAVHGGGNCQFALSADTSPTKDSKWMVIHSIEGGCPARNQKGNLEGPNADKYPFKIPAGIAPGDYVFAWIWLARVGGQPEYYMNCAPITVTGAKKRKMKKILRQFADRRALLARREQFPELFMANIGEVAGGCTTGEALNAQIPIAFPNPGIYVDHPEGAENLYKQPCDGNPRAGSPAEPGPGVGSPSSQAGTAAPTSTVVDGTVVPTASSAVVSSISSSSSMSGAKPVASNSPTTMSAEPSVPTGSCPAPIISTVTNEITVTVTATVMATSVTGSQSIGGPTTAPTASPGAPQPAPVNCSEGHLTCLPDETHFATCTGGKLTAPQPIAPGFKCAAGEGEGLDISPIVPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWP1</accession>
    <name>H1UWP1_COLHI</name>
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        <submittedName>
            <fullName evidence="6">Lipase serine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_04792</name>
        <name evidence="6" type="ORF">CH63R_08722</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000411">
        <property type="protein sequence ID" value="CCF32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155719.1">
        <property type="nucleotide sequence ID" value="XM_018303696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWP1"/>
    <dbReference type="GeneID" id="28867803"/>
    <dbReference type="KEGG" id="chig:CH63R_08722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08722"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027968_1_1_1"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR07201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="440" mass="49440" checksum="78BB45781E3DDDDB" modified="2012-03-21" version="1">MDYTGGTAEADHLCVLVHGLWGNPNHMAQIAKSLRAKYPADKLYLLLAKRNSGSFTYDGIERGGERVCAEIEEELRLIEARGGKITKLSIVGYSLGGLVSRYAVGLLHSKGILDSLECMNFVTFATPHLGVRTPLRGWHNHVWNVLGARTLSMSGRQLFTIDDFRDTGRPLLAILADPNSIFLAGLKRFKRHTLYSNIVNDRSAVHYTTGITKTDPYTNLDKVKCNFVDGYEDVILDPNHPVAPKPKVSEPATLSSVAAAGWKGIKRVPFVIALVIFVPIGIVAFLFSSVVQTVRSSKRIQLHEKGLAGVAIDEYRGPLWMKEIREEVEHVYETLNSSQDQEYLASETDDDLDEVEMDRSTTQLLARERRMSVPSQPTLALAPYQFQMIQSLDTVGWHKYPVWIHKDRHSHAAIIVRWEKKGFAEGHVVLKHWLNEEFVV</sequence>
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    <name>H1UX85_COLHI</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000469">
        <property type="protein sequence ID" value="CCF32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018295574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UX85"/>
    <dbReference type="STRING" id="759273.H1UX85"/>
    <dbReference type="GeneID" id="28859681"/>
    <dbReference type="KEGG" id="chig:CH63R_00599"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00599"/>
    <dbReference type="eggNOG" id="ENOG502S7E3">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="164"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="172" mass="18723" checksum="EA269F3FA9DE7810" modified="2012-03-21" version="1">MDAISTFSFGNLGWLATQAVPLIIWPRFITNLLRPEDYQAAGSLEDYFARSLGFALLTLGLLVVTLTGAVPLTAEDQTPPGTVSPHANAALVLSSIHHASAAFYCYSRYLRTGQTAFGLGCLGSAVFAVFGLWCLMFAGDKSRHSKKHGYDKDTSSFPFKNTESYRTKKKGM</sequence>
</entry>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000505">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1UXJ2"/>
    <dbReference type="GeneID" id="28870906"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11825"/>
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            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF32693.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR05122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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    </evidence>
    <sequence length="412" mass="44142" checksum="8FFE50BFF60617C8" modified="2012-03-21" version="1">MRVSIVAKAKETCEVGLSYYECNQGYRGCCHFNPCPGTECSRESTSTQSTKTVASVAAPILVSATDSGPPKKVIVTTTITTTTHKTQPPEGTTTTIFMYGSTGPGGAWYTDSEGRRISSISSPDPFLYPTTTATLVEPQILVTSTSIATPQPEAEKGGLSAGVRGGIAASILIGIIAIIAAWFLCTKQRKKLRTSRESISSINRDESKNSSEEDRPSPQMTAEPIRRENVFSSFGGRYEEPQTRFNRVSDTGSDRMMNHPISPDTRGSAVPQPQSAVIARATTASPDFTPRTANATPDFACRTANATPDLSRVATATPDFMCRLGTATPELHGPPQQAAIAELASPGLPRVVEIHSSRSGVQMYKPYRPIGGSLYPVAETTPSYLTGTLNATENERCQGQYVNSWAKWDSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1V147</accession>
    <name>H1V147_COLHI</name>
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        <submittedName>
            <fullName evidence="4">Isoflavone reductase</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">CH063_01055</name>
        <name evidence="5" type="ORF">CH63R_02877</name>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000957">
        <property type="protein sequence ID" value="CCF33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018297852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V147"/>
    <dbReference type="STRING" id="759273.H1V147"/>
    <dbReference type="GeneID" id="28861959"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02877"/>
    <dbReference type="eggNOG" id="ENOG502S12R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_3_3_1"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NmrA-like"/>
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        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
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        <property type="entry name" value="PCBER-like"/>
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    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NmrA"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="32269" checksum="1B43A75318B69932" modified="2012-03-21" version="1">MTSLKNILLIGAGGNLGLPVLEALLAIPSYKVRVLARKESTSVFPEGVPVFKADYSKQAEIQLAMEGQDVVICMVEPFATGNQNIFIDAAIAAGVKRFFPSEFGPPSRDPRFVDLKLHVVPAKAATVDHLRTKESQISWTSIVTGLFFDWAVKGGVLGLDPITKTARLVDGGTTVLTASNLPYIAKAVVACLDQAEETKNQYVYIGEFHVSQTDVLAAFEKVQGQEWTTANLDSETIIADGQKKLEDGDKSGVKDLVWGGTCGKRGMGDSRPWGLWDEKLGLEKASLEQVVSEILATW</sequence>
</entry>
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    <accession>H1V2K7</accession>
    <name>H1V2K7_COLHI</name>
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        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
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        <alternativeName>
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        <name evidence="10" type="ORF">CH063_06448</name>
        <name evidence="11" type="ORF">CH63R_12596</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001149">
        <property type="protein sequence ID" value="CCF34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151987.1">
        <property type="nucleotide sequence ID" value="XM_018307570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V2K7"/>
    <dbReference type="STRING" id="759273.H1V2K7"/>
    <dbReference type="GeneID" id="28871677"/>
    <dbReference type="KEGG" id="chig:CH63R_12596"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12596"/>
    <dbReference type="eggNOG" id="ENOG502RI2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042562_1_0_1"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR03469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="272" mass="31793" checksum="8C787D8A590AD3C4" modified="2012-03-21" version="1">MYELFLTTLVDDDDIQAACSVLGGLCAMPPWQSLHRVLYFKGPAKPGGISNQNSIPKTPRKDIQMLWKDLHQQLSRQSYILQARYEVFKDKDFGPNAPELDFNARPGTLRWTDFPDPPQNRSSVTQRKKTEIWDQKNLLSVMRDNNYQFKSEAVEETYQFFRDDVEFCFSRHYILQMNGDNGPLTQTATWDTMSPADPGRRWMFLIKVHVHQDNKPDEILKAHEQLANIRRELEGVFDFKMFDRRIHDTRVAVEMRNAPAPLPQVMTVTDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3J6</accession>
    <name>H1V3J6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_01202</name>
        <name evidence="6" type="ORF">CH63R_09920</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001279">
        <property type="protein sequence ID" value="CCF34798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154318.1">
        <property type="nucleotide sequence ID" value="XM_018304894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V3J6"/>
    <dbReference type="STRING" id="759273.H1V3J6"/>
    <dbReference type="MEROPS" id="A01.082"/>
    <dbReference type="GeneID" id="28869001"/>
    <dbReference type="KEGG" id="chig:CH63R_09920"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09920"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_4_1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497576" evidence="3">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="70"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF34798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR05800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="462" mass="48948" checksum="ED07C61AD88FCAC9" modified="2012-03-21" version="1">MAARLLPLAALVASVSAVSVPLEETKTKTSPGVLSLPVYQDIRIHPLENLRRRQVTDTDAPVLNVTSTTYLIELMIGTPGQDTKVAIDTGSSELWVNPNCVNAGSNAQTQSCRANGQYNPEDSSSATITSQTGSITYGKGKVILQYVNDNIAIPGSDIALRRTYFGYATDSIDLNRGILGLSFGEAVNNTGYRTVVDEMKAQNVIESLTMGIALGTKDEKTGSGLISFGGVDTKKYSGNLHTAPILPPQNGENLYRYWVQLDSVGLSKSGSNAKTYSNSKFPVFFDTGATLSYLPSALVDQLGSDLGGRLDSSVNMYVVPCNSRGTIDFKFGDYTMKVPLSEFIWQVSSSDCVLGADKATDGAYLLGDSFLRSTYVVFDQETPALHFAPYVNCGTNLQKIPLGDNAAARFTGECQAGSNNGGGGGGGDSSGNDENAAGRSTAANIWIATGALLAVQVFMSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5G1</accession>
    <name>H1V5G1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CCCH zinc finger DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_07244</name>
        <name evidence="5" type="ORF">CH63R_05146</name>
    </gene>
    <organism evidence="4 6">
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
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                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF36312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="419" mass="43630" checksum="C71EF8A14E30CBF4" modified="2012-03-21" version="1">MHQQALRSAGSRIKPDVVAIKTCIRNFSTTQLRAANEPSSDNKNNGTAARSPRAPLSTGRERSRAAASEIGQLLRGGPRAGGANNAGVGATAAKPNLIDIKTLPNREGSGGTNFVKLPQGFGRGGRGAFAGGRGRDLPSGFSAGGTGRGGFTGGRGRGGFGARGGGRGGGRGGGRGGRSGRGGRGGRGGRRGRDGEDGATEGARGHDLGKELESFFRPETAEEHAFIRAREQGFLPEAFNPSVSVEELLGFAPSMPISSSASGVAAPSAVMDTLREVGGGKHYAPDYWSDTQHTATELVFRGQGTYFFSDLAEKENFVRDVRTTPEDTASAEVKALKAVKLEEGAGAAVREYIIERIVKGQHTPAKFVEQAGRDPISRARESHLLNATYRASDGRKFDDKIASLVARKNPAAGSKTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1V844</accession>
    <name>H1V844_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07976</name>
        <name evidence="4" type="ORF">CH63R_13571</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001960">
        <property type="protein sequence ID" value="CCF36396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150863.1">
        <property type="nucleotide sequence ID" value="XM_018308545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V844"/>
    <dbReference type="GeneID" id="28872652"/>
    <dbReference type="KEGG" id="chig:CH63R_13571"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13571"/>
    <dbReference type="eggNOG" id="ENOG502T1WF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_593124_0_0_1"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497624" evidence="2">
        <location>
            <begin position="34"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="507" mass="56124" checksum="45EFA705231B3103" modified="2012-03-21" version="1">MVAIGHYPGSSKGKGVNTGVFLLIMAFLLGVAGAPSQPNGKIVSAKDGWDPVNRPIWTLRLEDRDRLTSGNAFALQNRDASSENAHFNQSTYNWDANDPPLWTIRPEDREDFVASKEDAHQLKTRNINDTIPCVNKDKPATLYHTYSIMDCPPKNKFLSFSDGMMRFDTCEGWNKGPDKYKKDGCMSFCETDTTFEWAQEVPFPHSQCHYSVKCGMAETDIVNLGWNVGRNTTVNTLKALKDGISGGWDHSYSTARGKKWDVDLMEGECGYFTFVPVKKVVCGGMTEPASPPGDSGLCTTDPKNHRQCDDQLWTIKAKNANGTAHAEITDGTILFVYTDCLTRLPLSMDKQDPVYRAPGVALSPKALDTIQQGWVWNTCYLWNMGIKGQLSLYIHGSGFKDSMIGPKGQKLIDRVRSCVKASKGTMNNIEFVWYHSGYPGDDAKITGAMWVFMADVPDTIKPGCLGEAIIELGGATTDKRFYFARYILIMIAVSLGGPVMPLSHKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_07999</name>
        <name evidence="4" type="ORF">CH63R_03087</name>
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    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001973">
        <property type="protein sequence ID" value="CCF36423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018298062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V871"/>
    <dbReference type="GeneID" id="28862169"/>
    <dbReference type="KEGG" id="chig:CH63R_03087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03087"/>
    <dbReference type="eggNOG" id="ENOG502SFBG">
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    <dbReference type="HOGENOM" id="CLU_061843_0_0_1"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="224"/>
            <end position="243"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF36423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="297" mass="31573" checksum="37860EABF636FF9D" modified="2012-03-21" version="1">MASDSPRPDSSPQKADFEQSRPADIAAEGEQSTKQDSTTPEGAGGNDFKRDSSSPESGEASSTASPAPSDAGDEKTASSSDAPPLPDEVPPLPSGPPPATQDDGWDFQWDPASQAYFFYNRFTGATQWENPRVPVAAAAASTSAAPGTTTTAATTAPLGPPPLSTNDLPPAGGYNPAIHGDYDPDAWYAKGNTAEENEANQASSAAYAAEYGATAQFNRFTGQFQTLGEGPDRHSDEAKSKRQMNAFFDVDAAANSHDGRSLKAERSGKKPSKAELKQFKEKRRARKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8T8</accession>
    <name>H1V8T8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_08164</name>
        <name evidence="10" type="ORF">CH63R_07166</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002073">
        <property type="protein sequence ID" value="CCF36641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156919.1">
        <property type="nucleotide sequence ID" value="XM_018302141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8T8"/>
    <dbReference type="STRING" id="759273.H1V8T8"/>
    <dbReference type="GeneID" id="28866248"/>
    <dbReference type="KEGG" id="chig:CH63R_07166"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07166"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_4_1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF36641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="539" mass="60415" checksum="9C0295C2F153DA67" modified="2012-03-21" version="1">MLVAELIHGLSHEATQHPIAFLSKFLVISALVYFIVNEIVRSKARLSGWHGPQGLPLIGNLYQLRGNASQKYREWAKEYGPVYEVQLGNLPVLVVNTAAAARVMFGNNSQATASRPELYTFHKVGVILLSSSSAIIADARKIVANTAGTTIGTSPYNESLKRRRKGAASALNRPSIETYIPHLDLETRDFLKDALTYGKAGSVAVDPLPLVQRLSLSLAVTLNWGMRFPSHDDGLFKEITTVEGEISRTRSVTDNMQDYIPLLRLNPFSAGKRHAVEMRSRRDRYLSKLNGDLEEKIRNGTHEPCIQANVMLDEEAKLNKVELTSISLTMLSAGFETFTAVSTWGIGFLATHPEIQRKAFNAIREAYDESNPLCDAHDDQTIPYVRALVRECLRYFTVLRLSLPRATNKDFVYEGKLIPKGTVVFLNSWACNMDNELWHDPEVFRPERWLENPEAPMFTYGMGYRMCAGTMLANRELYITFLRMLASFELSSATKIDSDPVTGAADLTNLIITPGHYKVTFTPRNEVALRKSLETEVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8Y5</accession>
    <name>H1V8Y5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_08195</name>
        <name evidence="8" type="ORF">CH63R_05487</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="MacDonald P.J.P."/>
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            <authorList>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Voll L.M."/>
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                <person name="Young S."/>
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                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
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                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Panstruga R."/>
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                <person name="Proctor R.H."/>
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                <person name="Rounsley S."/>
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                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
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                <person name="O'Connell R.J."/>
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        <property type="nucleotide sequence ID" value="XM_018306341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VA35"/>
    <dbReference type="STRING" id="759273.H1VA35"/>
    <dbReference type="GeneID" id="28870448"/>
    <dbReference type="KEGG" id="chig:CH63R_11367"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11367"/>
    <dbReference type="eggNOG" id="ENOG502RPCJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104296_0_0_1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF37088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="184" mass="21124" checksum="C184EA8DBADF3897" modified="2012-03-21" version="1">MLAPPEAKDYYKTEEYRLKLDDDIVSIRNQLDSGIGDKLFDKYRAKENNLDEFEGQYQVIIVGALMMRAGANISKEQLQHLRDLVPKIDCQYGYALPFRDLGFRDPGKAQFLAALDNYQPGAPRDYLEPSCFHCGKVRADIGKAPKGCGRCEQAWYCNVDCQRAHWKVHKPQCKHLNEVRILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VB01</accession>
    <name>H1VB01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_08754</name>
        <name evidence="5" type="ORF">CH63R_09189</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002452">
        <property type="protein sequence ID" value="CCF37404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156186.1">
        <property type="nucleotide sequence ID" value="XM_018304163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VB01"/>
    <dbReference type="STRING" id="759273.H1VB01"/>
    <dbReference type="GeneID" id="28868270"/>
    <dbReference type="KEGG" id="chig:CH63R_09189"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09189"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF37404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="352" mass="38659" checksum="9887A8BBF74932AA" modified="2012-03-21" version="1">MTSLTNPAIPKGSIVLVTGINGFLGSHVADQFLQYGYNVRGTVRDVNKSSWLCDLFDGKYGKGRFELLAVPDITVEGAYNEVVKGTSAFVHVAAVVGLNPDPNQVIPTAVSGTVNALKAAYSEPSVKRFVLCSSSAVVVPADPETYKQPHVVTEDSWCQDSLKLAWAPPPYTPERAMAVYSASKLECELTVWKYHKENRNARPDLVVNSVLPNGIFGKCLDVTNQGYPSSAGLIQALWSGAQVPEFIRAPQYFVDAQDAGTLHVAAAVLADVQDERIFGFAEPYNWDRILGILRRQNPDHSFPDDFEGSAYPHTIKPRDRAEELLKIMGRPGWTSLEDSLLQNTEHLRQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBJ9</accession>
    <name>H1VBJ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3 exoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08895</name>
        <name evidence="3" type="ORF">CH63R_05362</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
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        <source>
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    <sequence length="308" mass="34546" checksum="DF33E379071A0A9C" modified="2012-03-21" version="1">MVRRGGKSSRAAGPSLDPTPIPSTLTTPLSSAYPSTYTSEAEWDALGDSISSLTLSEKRAAKRRAKPFPFMALPSELRLKIYDYYFEGGGEVIDLDPDNYKNFHKKLGIQRTCRTIYREVSHYFYSSRSFRIFPTHPGKYFKTKKPLLARMKPSSRSLITSLELRLGPGWSKPPRGWIVTPALGLNECVNVRRLTVMVECDPSDGIFNGFRRSHGFYESFSQSLLIEVLNQMPWVDTVTFDAWSSVKKSGAMMRGLLDVTAANNRKIRWGPERGWTDGPDEEDKVGNLVLVPPASEFNTSSMGVLVMA</sequence>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002551">
        <property type="protein sequence ID" value="CCF37620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161170.1">
        <property type="nucleotide sequence ID" value="XM_018299924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBL7"/>
    <dbReference type="STRING" id="759273.H1VBL7"/>
    <dbReference type="GeneID" id="28864031"/>
    <dbReference type="KEGG" id="chig:CH63R_04949"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04949"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_021165_2_0_1"/>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Snf7_fam"/>
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        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
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    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
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        <property type="entry name" value="WHD_CHMP7_1st"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="394"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF37620.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR12653.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="475" mass="53015" checksum="941202EEFFA0315C" modified="2012-03-21" version="1">MGELADFLVERDENFRKARLPALYSDFRPQRTLNPDGFQANVSAWRQALARAAWEGRIASQISAPNLLVVNVDEQLARSLESKQFGRPLALGTVVREALSERDLYPLKEFLDAKDSIYAGKTWAQVPWSVVSWAAGQLGFGGKSTAGEDKLPQGRFVVIKNAETAAKSLAEKVKSSDTRFDRTYTKSHFRKTFADTIVQDRRLSEMDVDILLVFLSRDKGIMIYDGHVVKIKGATDEEESAITEEDAAVSSLKELIADMKEQAELLTRRIDELTTTAKEAVSKKNKVAALAALKSKKITEASLAKRFATLNQLEDVAARIQEARDNVQLVKVMEASTGVLKGLNEKVGGADRVGDVVDRLREQMGEVDEVGKIISEAGAAPVDEFEVDDELEAMEREEREREEALERARKEAQEAKEAEETRRRLEKEMADLRSPVTEPAEKEGAREQVQTPARETADNLEKLDLEEREKPLPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Integral membrane protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">CH063_08972</name>
        <name evidence="6" type="ORF">CH63R_13420</name>
    </gene>
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    </organism>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
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    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takahara H."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
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    <dbReference type="PANTHER" id="PTHR43706:SF45">
        <property type="entry name" value="NADH DEHYDROGENASE-LIKE PROTEIN RV1812C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF38190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="43342" checksum="864A0C9D0407275F" modified="2012-03-21" version="1">MSSTILIVGAGFAGVWSALSAKRLINNSSDRANTINIVVVAPEPFLVIRPRLYETNAASMTHPLAALFEAAGVQFLQGTVETIDTQAHTVHVRSPTGPDPEVVSFDRLILAAGSSVVRPQGVTGLGQHAFDVDSLESAAKLEAHLESLALSPPSAARDTVVVCGAGFTGIELACELPRRLSHLNSPRIVLIEGADVLGPELGPGPRPVITQALEDLGVEVKLGSAVAAVDNQCVTLVSGERIETMTAVWTAGMRATPLTEHIPGTKDTLSRVHVDKHLRALSSAHVFVTGDAAYASADDQGHHALMSCQHALQLGRVSGHNAAADLLNEPLLKYSQEAYNCCLDLGSWGAVITGGWDKEVRMTGSLAKRTKGYINQKLIYPPSDAEEALLAANPVGPDSDDLIEKIFVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VDB7</accession>
    <name>H1VDB7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_09363</name>
        <name evidence="10" type="ORF">CH63R_10944</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002870">
        <property type="protein sequence ID" value="CCF38220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155342.1">
        <property type="nucleotide sequence ID" value="XM_018305918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VDB7"/>
    <dbReference type="STRING" id="759273.H1VDB7"/>
    <dbReference type="GeneID" id="28870025"/>
    <dbReference type="KEGG" id="chig:CH63R_10944"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10944"/>
    <dbReference type="eggNOG" id="ENOG502RSJA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019101_0_1_1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF38220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="434" mass="47788" checksum="76D63BCE19A065FE" modified="2012-03-21" version="1">MDPAAAEAAAAAAAAAMRSFTIEAWTLLAVGILITMLRTYSRIRSVGIRGLQADDYLVWVGAIFYAVETALAHSVGAIAKGMANNGMTDEQRAALSPDSEEYRLRVVGSIIQICGWSSYSVLLWALKASLLVFYLRLTAGLGRGYQLRIYFGFGFLVVSWIAVVMNLFLACRPFHKNWQIYPNPGNVCQPAISNQIVWVYLSFNVSTDLYLLSIPLPMLWQAKLRPAKKYGLLLLFSGGIFVVVCATLRCILIVTDPQNGAQLAGSWAVRETFVAVITANLPMVFSVVKNWLAPVFGSIITSLRSSQKLTEGTPKEIRTFGAGSNQSWRGRGPPSAYPITNVTFSESEERMVNEYKMQDLKPWGDPHGEPVDVGRSDGVQRSQSNRGKNTDIRKDVEVAITTEYVRDSGDELPQDYAYIKGTKRASSQIVSESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEE1</accession>
    <name>H1VEE1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_09644</name>
        <name evidence="2" type="ORF">CH63R_05818</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003049">
        <property type="protein sequence ID" value="CCF38594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158643.1">
        <property type="nucleotide sequence ID" value="XM_018300793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEE1"/>
    <dbReference type="GeneID" id="28864900"/>
    <dbReference type="KEGG" id="chig:CH63R_05818"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05818"/>
    <dbReference type="eggNOG" id="ENOG502T4QD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180921_0_0_1"/>
    <dbReference type="OrthoDB" id="3513895at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF38594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="79" mass="8604" checksum="D793F029D2E454E2" modified="2012-03-21" version="1">MPETESKAIRRPPVKVELALPPLYQGKGSYTQTPKEARDVQFALPGSRSKPVEVLQIDSAAVPQPFVDPAVFKKWGGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGY1</accession>
    <name>H1VGY1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_02141</name>
        <name evidence="15" type="ORF">CH63R_08087</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CACQ02003523">
        <property type="protein sequence ID" value="CCF39484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157839.1">
        <property type="nucleotide sequence ID" value="XM_018303061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGY1"/>
    <dbReference type="STRING" id="759273.H1VGY1"/>
    <dbReference type="GeneID" id="28867168"/>
    <dbReference type="KEGG" id="chig:CH63R_08087"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08087"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF39484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR09322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="399" mass="43752" checksum="3B2943D517324B9A" modified="2012-03-21" version="1">MAEGTKAQERFALIQENLAEIMNPEIIEKILAEGRNPKIYWGTATTGRPHCGYFVAAIKLAQFLAAGCELTVLLADIHGFLDNLKAPIELVEQRAKFYKFAITNILNAVGVSTEKLKFVLGSSYQKSPEYIMDVYKMSSLISERDAKKAGAEVVKQSDNAPMSGLLYPVLQVCDEEHLGVDAQFGGMDQRKLFAAATEWLPKVGYQVRAHLLNPMVPGLNGGKMSSSDPDSKIDLLDAPEVVQKKIRKAECVPKVAEGNGVLAFVEYVLLPAAALKGKKEFRVERERDGLDPLVYTNIAEIHTDYTNDVLTPQLLKPAVTKALNELLLPIQKAFQDSEEWKEITQKAYPPVEDDKKKKKKQPKDKGSRYPGGGKGGAAAQDGAVKESELPVRPADGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VHI6</accession>
    <name>H1VHI6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_02180</name>
        <name evidence="14" type="ORF">CH63R_07538</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CACQ02003635">
        <property type="protein sequence ID" value="CCF39689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157291.1">
        <property type="nucleotide sequence ID" value="XM_018302513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VHI6"/>
    <dbReference type="STRING" id="759273.H1VHI6"/>
    <dbReference type="GeneID" id="28866620"/>
    <dbReference type="KEGG" id="chig:CH63R_07538"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07538"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_5_1"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="155"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="378"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="587"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF39689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR08773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="636" mass="69043" checksum="500BB2DF4896D908" modified="2012-03-21" version="1">MDVFDTANMQAALSSESSEKKAPAAVIDNEGKAWAKPLPYNYDELAKQGPVETTDWEGNGAIYEWNDEFGDVGPKFPELELALFGNPDTRHDHSGLDFSVQLTFVSISSVDVSQDGPTRVEPVHSYKDAGLHPVMLENVELAGYEAPTPIQKYTLPAIHKGLDVVAVAQTGSGKTAAYLIPILNKLMGKAKKLAASRPNPSEVALGQVFVRAEPLVVIVCPTRELAIQIFNEARKFCYRTMLRPCVAYGGGPIRDQIQQLGKGCDVLIASPGRLCDFIQRPDVLSLRRLRYMVFDEADEMLHDDWREEFDVIMTGGEQQEGSIKYMLFSATFPKPLRDLAKEHLSSSSVRINIGRIGSTHANIMQRILEVAPFDKKTALKDQINSLPACRTIIFVNSKRTADDLDDFLYNMGFPCTSMHSDRTQLERESSMRAFRAGKTPILIATGISARGIDVKNVNHVINYDLPSMDHGGIEEYTHRIGRTGRMGQRGIATSFYTERDEPIASVLVRTLLETKQEVPEFLEPFKPTGKGLENLKFETESDFDPEEAGVAHLGISSGDGGWSNEGYGGDDDDAAAAAAATGDDAAWGGGGGGGGDASAGGNSAWGGASDNTGNEIKKKEPQAASVWESSAGGSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJZ3</accession>
    <name>H1VJZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RNA recognition domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_02379</name>
        <name evidence="14" type="ORF">CH63R_07693</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004204">
        <property type="protein sequence ID" value="CCF40635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162771.1">
        <property type="nucleotide sequence ID" value="XM_018297955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VK82"/>
    <dbReference type="STRING" id="759273.H1VK82"/>
    <dbReference type="GeneID" id="28862062"/>
    <dbReference type="KEGG" id="chig:CH63R_02980"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02980"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_15_0_1"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="268" mass="30057" checksum="BB23D2DAF735EE39" modified="2012-03-21" version="1">MTSEQKPKVKLYWLEQSRAQNILWLLEELKVDYEVEVFHRNKQTLLAPPELAKIHPLGKSPVIDIFPTGSGESITLAESGYMTQYLCEHFGQDTNLIPKKWKDGQEGKLGGETEGYSRCQYLLHYVEGSLLPVLTLSLVIGALKSDNVPFFVRPITSVVANKIFSMMVFPNAKKHLALIDQMLETSPNGGKYLCGEHLSAADILLSFALIAAEPRFDTLGSWPGGSARAAHPRVFEYIDRLKKEPGYERSAQKIREIDGKFEATISKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL28</accession>
    <name>H1VL28_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_02465</name>
        <name evidence="5" type="ORF">CH63R_04066</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004390">
        <property type="protein sequence ID" value="CCF40931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160287.1">
        <property type="nucleotide sequence ID" value="XM_018299041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL28"/>
    <dbReference type="STRING" id="759273.H1VL28"/>
    <dbReference type="GeneID" id="28863148"/>
    <dbReference type="KEGG" id="chig:CH63R_04066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04066"/>
    <dbReference type="eggNOG" id="ENOG502QSZT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF40931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="350" mass="37157" checksum="2DB833D868CE927E" modified="2012-03-21" version="1">MSSNGPITTPITQLLGIRHPILLAGMARTSGGPLAAAVSNAGGLGVIGGFQYTPDQLREIIAEMKENFKSPDLPFGVDLALPQVGGNARKTNHDYTGGKLDELVDITIESGARLFVSAVGVPPRHVIDKLHAAGIYVMNMVGHPKHAIKALDLGVDIVCAQGGEGGGHTGDVPNSVLIPAVVDVARRYRPKMLKGSPALVIAAGGIYNGRSLASSLMQGAVGVWVGTRFVASVEAGCSEEHKQEVVSCGFEGTERTLVLSGRPLRLKTNDYIRKWHAQPDKIKQLCDEGVVPIEYDFEKGNDIDPPHLMGQVAGAIDKIQPAGEIVDEMIREAVDQLKLGQVYLGARSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL38</accession>
    <name>H1VL38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_11371</name>
        <name evidence="8" type="ORF">CH63R_03441</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03441"/>
    <dbReference type="eggNOG" id="KOG0255">
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR23502">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TCRTETB"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="121"/>
            <end position="145"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="206"/>
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            <end position="234"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="560"/>
            <end position="578"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="121"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF40941.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR14715.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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    <name>H1VME5_COLHI</name>
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        <recommendedName>
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        <name evidence="8" type="ORF">CH63R_04803</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004678">
        <property type="protein sequence ID" value="CCF41398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161024.1">
        <property type="nucleotide sequence ID" value="XM_018299778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VME5"/>
    <dbReference type="STRING" id="759273.H1VME5"/>
    <dbReference type="GeneID" id="28863885"/>
    <dbReference type="KEGG" id="chig:CH63R_04803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04803"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF41398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="253" mass="27897" checksum="4161D8403A013B00" modified="2012-03-21" version="1">MRLTAELIKGSLSYLNPLKERELDLRGHRIPAIENLGVAGPHDSIDFTDNDIQVLGNFPLSPRVQTLLLAHNRVSSIQPALPNAIPNLTQLVLASNQMAELADLDVLAGFKRLTHLVLAENPVTKKENYRYWVVWRCPSVRFLDYQKVKEAEREKARELFGTAQEPTAEASKIMGIKSKQLDLGASNGVAGGGGGGAPSKLSRIKLTDKEKERLKEMIKKADSLQEIIRLEKMLTEGTIPAGVHLDGDATMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPF5</accession>
    <name>H1VPF5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_12192</name>
        <name evidence="2" type="ORF">CH63R_10463</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005147">
        <property type="protein sequence ID" value="CCF42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154861.1">
        <property type="nucleotide sequence ID" value="XM_018305437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VPF5"/>
    <dbReference type="STRING" id="759273.H1VPF5"/>
    <dbReference type="GeneID" id="28869544"/>
    <dbReference type="KEGG" id="chig:CH63R_10463"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10463"/>
    <dbReference type="eggNOG" id="ENOG502QR0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024804_2_1_1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="511" mass="57122" checksum="665B4BFBFDAFB05B" modified="2012-03-21" version="1">MDLTRRPTEHERDWFYNGLFSHPKLVARSSFTSFKDGKDSWSSPKKTLAVVGEHAIVSQWNDEPSSLRNQILGILAREKVNWQAIDILRIGYDGEEMPVIVSISVLADTLSWVMGNQVAFHCRNALVEHGFDDVHCEIKESTLVNLASTPAVLQQDSHQHRPFLRPYMYELADQLGTSIASLDQPRREGTKGIYLRRTGGDPDEVFALTCRHVCYDESETGCLLPRERSLPGKSVIQLPERTRKAVVADLEDLKYQSVKVLRGDGKATGESYDDKIITECQQNVNEISAVLQHFTLREALEARILGDVAYASEYAVGSSGLLSDWCLIRLRADSHERRLSELSNRVYIDGKELERRFQALVVLIKDLDQDGTLHIHGIVAASKLQNSTRFRRLVGMSGRTSGVTFGEVNQAKSVVRRVSHDGTPLISREVGVVAERMQKSDPFARKGDSGACVFDLEGRAVGMVSGGIKREEVLKEDDDYIHDLPADVTYFTPMESILADMKACGLSMEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VRG0</accession>
    <name>H1VRG0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_12708</name>
        <name evidence="3" type="ORF">CH63R_03699</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005666">
        <property type="protein sequence ID" value="CCF42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018298674.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VRG0"/>
    <dbReference type="STRING" id="759273.H1VRG0"/>
    <dbReference type="GeneID" id="28862781"/>
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    <dbReference type="eggNOG" id="KOG0578">
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    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF84">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="315" mass="35132" checksum="351B6C659C8D124C" modified="2012-03-21" version="1">MIPRGLASAFGTPSLEIGQILLGNASRYTIQKKIREGVWIATNPMGNKSIVKGVQGISGAQNEHNVLRKFQGNPFLRPVIDEIQQDAPMIVLRHMDDHLLNATIKKPLTNREIRFVARAVLRGLSTLHKDGYVHTDIKPDNILVNYASDSEADPDLRFSDVQIGDLGASYSIDSDVATKGFLIGAPIWTSPEVLMEVPWGTASDIWAFGSMMIALLHGGDYNPFRPTNARYHDRSYVFEVLRQQSRRFGAIPETYLERARPGKAMAAKALTVGRKVEPLDFRTASHFINRIMRMDAAERPSADQLLEEMSGLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1VS09</accession>
    <name>H1VS09_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_12836</name>
        <name evidence="3" type="ORF">CH63R_09804</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005798">
        <property type="protein sequence ID" value="CCF43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154202.1">
        <property type="nucleotide sequence ID" value="XM_018304778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VS09"/>
    <dbReference type="STRING" id="759273.H1VS09"/>
    <dbReference type="GeneID" id="28868885"/>
    <dbReference type="KEGG" id="chig:CH63R_09804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09804"/>
    <dbReference type="eggNOG" id="ENOG502TMT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2399560_0_0_1"/>
    <dbReference type="OrthoDB" id="3658758at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010117795" evidence="1">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="93" mass="9513" checksum="7304ED08267A3D71" modified="2012-03-21" version="1">MQISNVLAAALLAMSVSAQKTGPNGKRICVGGAISCQYQKGRCANICGDSFVNGQGTPAFIDPNCSCPEGQADNKYTGAACIDVVRALGRQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSV7</accession>
    <name>H1VSV7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_03042</name>
        <name evidence="8" type="ORF">CH63R_07761</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006012">
        <property type="protein sequence ID" value="CCF43315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157513.1">
        <property type="nucleotide sequence ID" value="XM_018302735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSV7"/>
    <dbReference type="STRING" id="759273.H1VSV7"/>
    <dbReference type="GeneID" id="28866842"/>
    <dbReference type="KEGG" id="chig:CH63R_07761"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07761"/>
    <dbReference type="eggNOG" id="KOG2347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011308_0_0_1"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115920" checksum="B6EC9D21814E4BD3" modified="2012-03-21" version="1">MASEYERTILDFYQLPTPYPNEWPAEKNQSDASDDEGDIQDEKKAKLQRRKSRYQALERAVSDRRSTIPGAQSEKGGVGNIVQRDEPDPLGTTDSVVRTLRQLGVPIQDDPRLRNRFLLSSTTFSPALFLSQMHATADTQSLLVGLDTLSQSIDQKSASLKVLVETNFERFVKAKATIDNVYKEMKYRGAEPPPPPPTGRARAHSRHASRSSFRGSNSNLNLAASLGSPTSDARKKNALVKESEYGVAGIKAPLLDVSAKAEDVWGPALGGREKEENLKIVSANLDQFKDYVELSSAIADSIKRRDYESLVEEYNKARKFSDNARALAANIPPDAPSDAIYQIVLAARMWHDVDEQIQAFKRDVWRKLITLHGVAKADNVGQQDQHMELISLLLELGVDDNPIWVWLLSRYDHLKGKIQSTSDRSKVEVEVLRRRLANADKPGSHMVASHLRSLGRAAVEDKIASADSADVIELWEKMLAFLSSILSSQGILGEVVDFWQIVQGFLDGKIQRTLPLGYNGESQHHHQLTEQGAGDLQKGTLELVDMIRETVFAFFAGPPPEDISLLFSPLPMSPKSPPSAGAGNLTPTGLRDPRLNLDPNNIPPPSPKRGETWEKLAFWPPWSNSVSGVHYLSKMLALVGSGASDLASIGPVVNGPDASILERLKSLVNVARERCVTALCAAWNKDAENIKFVEDWHRSPELGDLTRMPSSFSAFEGALLGGMQKILYISEAMSKPGAGDIVLPPPSKLLQMVRSQYVTTLYKALSGMVENAERSVKKVDDDWTTDMDGTIVATAPPAPSGGRATLDAGDRNVRMLLTLSNLQALRAKVVPSLNSQFENAFSVKLSDESKTIKDVLGQIDARLFQSYTRPSIEQLRNIVQAGVASTDWVPEPGQKPREAKPYVYEALLSLVLVHTQVSTTAPTLTSQVLSYLLEQTSRELLEAFRTRQRYTLEALMQATLDVEFVAQTLSQYTTDRASQLQSEIYQELDGRTDNDARARLQSELPEMRSVLKRLREASKNEFACFRKIKRPGMGPTRTGTGDSVSSIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VT54</accession>
    <name>H1VT54_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial hypoxia responsive domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_13117</name>
        <name evidence="13" type="ORF">CH63R_06195</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006080">
        <property type="protein sequence ID" value="CCF43412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159020.1">
        <property type="nucleotide sequence ID" value="XM_018301170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VT54"/>
    <dbReference type="STRING" id="759273.H1VT54"/>
    <dbReference type="GeneID" id="28865277"/>
    <dbReference type="KEGG" id="chig:CH63R_06195"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06195"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_0_0_1"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF43412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="231" mass="25441" checksum="80D8328FED773B68" modified="2012-03-21" version="1">MPGPDGKPTLLDRSMPSSFDENNEFYDERILHKVFRKLKEEPLVPLGCGLTVFAFVSAWRAIRRGDSVQANKMFRARVAAQGFTVFAMVAGSMYYNKDRERTAELRKIKEANEAEEKRQRWIRELEARDDEEKALKAMLQKKRAKAEAKNSGAAGDEAPAEGDKAKSGGVLGALGLSAWTKPEEGDAVSEATSAEKPQKKENPNSTLGTIGEIYGRKPSSSDGSSSEEPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWC1</accession>
    <name>H1VWC1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_03357</name>
        <name evidence="8" type="ORF">CH63R_06839</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02006968">
        <property type="protein sequence ID" value="CCF44532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159664.1">
        <property type="nucleotide sequence ID" value="XM_018301814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VWC1"/>
    <dbReference type="STRING" id="759273.H1VWC1"/>
    <dbReference type="GeneID" id="28865921"/>
    <dbReference type="KEGG" id="chig:CH63R_06839"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06839"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_0_1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF44532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="516" mass="55748" checksum="873498B2605C8627" modified="2012-03-21" version="1">MAATAKGQDGHLQKRFSKLTMIGMAFAILNTWISLAGSIGLVMPSGGSVSFVYGFIFCVLCNICLSSSVGELASLYPTAGGQYHYAYALSTPKWRKMTSFFVGWVNIAGWLTLNTTAAYFGARFLAAAAVAASGGTYHISQWSTYLMFVAVSIIGVFLNIFAYPILNRWNEGALYWSLISVVVISIVLLATSPKMDAEFVFTNFSNTTGWSDGTAWMLGLLQSALSLIGFDAVAHMTEEMPHPSKDAPQAMVGAVLVGGTTGIAFILVMLFCAVDIDVLLASPTQSPLTEMILQATRSKAAATVLSVAVALCFVNGANGCVTSGSRLVWAMARDDGTPFSKYLSHLHPKLNVPVRAILVQAVFNLLFGLLYLGPEVAFNAYIASCTLFLNLSYAMPVMILLVRGRQMVTANPPEFTLGRGLFGYVVNWTSVLFVLVTSIFFCFPPAIPVNVSTMNYVTAVVGIFVVYAISLWFIKKKSYNGPKFELILGEELPVANPITKEHASGKEAEFLPHDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VWW5</accession>
    <name>H1VWW5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_00528</name>
        <name evidence="2" type="ORF">CH63R_02303</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <sequence length="389" mass="42509" checksum="30ABF877F6345312" modified="2012-03-21" version="1">MATVTIQSPLSRRGHGPGLLILVEQGIDLSKHDTILDPPPAQKWAEEGYAVAQVIIAPGVGDVANRVSAAIKSLRDLDSCDDKEKFGVIAHLAVASQQVADALESHPEIKAVVFFNFAQALAIPTLSHVPGIHAGALKTTATTGSAAAKSYSYPAARDFFVVPGHSHFDANAAGLAHTRTLTFLKPVLGGPYFDLEAVWEEHTLFEFGERDVEKTMATMVEQPYVNHIPTLTGGVGRGRLTNFYRDHFVFNNPDDTELQLVSRTVGIDRVIDEFIFKCTHDKVIDWLLPGVPPTGKHLSIPFTSVVNVRGDHLHHEHIAWDQATALRQLGLLPDYLPFPYQINGSDPASGKRFEFRLPVAGVESAHKLVDESAVESNAMFEYAAREVDE</sequence>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
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                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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        <property type="protein sequence ID" value="CCF44910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02007859">
        <property type="protein sequence ID" value="CCF45561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161694.1">
        <property type="nucleotide sequence ID" value="XM_018296878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VZ99"/>
    <dbReference type="STRING" id="759273.H1VZ99"/>
    <dbReference type="GeneID" id="28860985"/>
    <dbReference type="KEGG" id="chig:CH63R_01903"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01903"/>
    <dbReference type="eggNOG" id="KOG1200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_1"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF45561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="249" mass="26130" checksum="06F30B403149E94E" modified="2012-03-21" version="1">MASSFRNRVIIVIGSASGMGLAAAKTLLAEGAKVGMSDVNGAALDRVVQELDTEQQTRVFHRAADVTDRQSVKGFLEETKSRFGSVDGVANFAGCGGHELGTQSIWETSDEEFEFITSLNIRGAFHVLAEALKPGYLSHGGSFVHVGSMFSLQGFYKGAVFAGSKHASLGMVKSAAKEVGGRARVNCVLPGAIDTPMHRANLARVPKDFPAPTIVGKAKEVADVTVFLLSEKSAFVNGAAWNVDGGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2K9</accession>
    <name>H1W2K9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear distribution protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_03936</name>
        <name evidence="10" type="ORF">CH63R_03335</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009000">
        <property type="protein sequence ID" value="CCF46722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163126.1">
        <property type="nucleotide sequence ID" value="XM_018298310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2K9"/>
    <dbReference type="STRING" id="759273.H1W2K9"/>
    <dbReference type="GeneID" id="28862417"/>
    <dbReference type="KEGG" id="chig:CH63R_03335"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03335"/>
    <dbReference type="eggNOG" id="KOG1853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034391_0_0_1"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="131"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
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            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="578"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF46722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR14609.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="597" mass="65475" checksum="B8937D25D868B9F3" modified="2012-03-21" version="1">MAEPPSSPPNEASSPEDQLRWYKSQYASLEEELAEFRESSKELEQELEKDIDQAEKRERKLQEKAESLKFEAEEWKSKYNQAKKDANAAQNTLEKEITTLRDTNRTLQLKLRDIEVANDDFERQARNTSSSLEDLESKYNSSIERNVMLEEEIKIGEQERETLRIEAQRLREELSDLKIEAELLQDKIKKQEARHLSAISTDLSILSSPTFDKTMEASPGSTASSPMVSTPPDGEALPAAKKSQISEPPSPPMSDVSASVPKRIVSRTPLKTPARTPASATRKSRLPSTEHSITPKPRSFTTSITSSRPAGGRPSTGPPTRPPVPRTTPRSVSTRMPANNSLNHIRSLTAQMQRLEARVQNVRSKLPAPVTTPPRASPRSSVLGVHSVPSTVTIRSRKRPTGSTASRDDTTPSNPNFSASTRSRHVSRLSTSGVSRLSFGPLPNRNPGASVGHEQESAISRPSSRASISSYARPPSRTEMAPPRPISRASMSGSRTPLGRPRSSLGGALHARSASISSRIDIEEGDESGEYRTPSRRGTFSRLEAETAVSGIPVPTSSIPMPSSRRQSGSSVSGRRSSMALRSSVMGVRDLVEEETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1W2L9</accession>
    <name>H1W2L9_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CH063_15393</name>
        <name evidence="17" type="ORF">CH63R_01032</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02009007">
        <property type="protein sequence ID" value="CCF46732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164369.1">
        <property type="nucleotide sequence ID" value="XM_018296007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W2L9"/>
    <dbReference type="STRING" id="759273.H1W2L9"/>
    <dbReference type="GeneID" id="28860114"/>
    <dbReference type="KEGG" id="chig:CH63R_01032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01032"/>
    <dbReference type="eggNOG" id="KOG2831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_2_1"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="66"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="264"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF46732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR15852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="338" mass="36465" checksum="5795FC8C1691C9A1" modified="2012-03-21" version="1">MSQFTEKLMTKQSLEGRLLFAVPKKGRLNSATLNLLEGADIQFRRENRLDIALVKNLPIALIFLPAADIPTFVGEGRVDLGITGWDQVREHDAGVIATNKARRASVELGSNGVEALQKAGGCEMVMELGFGHCKLQTQVPEKGAYSTTEDLIGKTIGTSFVNLAEEHFAKLELGVDSDGNSNTSPKKLRTKIIELSGSVEAACALGVADGIVDLVESGETMRAAGLKAIDTVVDSQACLIKSRSPSNIELVELIAARIRGVITAQRFVLCQYNIERSRLADAKAITPGKRAPTITTLDEEGWVAVSSMVEKKKIALVMDNLTRVGAQDILVLDIHNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3C4</accession>
    <name>H1W3C4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_04009</name>
        <name evidence="9" type="ORF">CH63R_12913</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009246">
        <property type="protein sequence ID" value="CCF46987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152304.1">
        <property type="nucleotide sequence ID" value="XM_018307887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3C4"/>
    <dbReference type="STRING" id="759273.H1W3C4"/>
    <dbReference type="GeneID" id="28871994"/>
    <dbReference type="KEGG" id="chig:CH63R_12913"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12913"/>
    <dbReference type="eggNOG" id="KOG3901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076665_1_2_1"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF46987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR03786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="176" mass="19666" checksum="BCB13DF6CB27D32A" modified="2012-03-21" version="1">MEPRARAAKNVGKMNFSHNELGQLLYAHGDVRMPLPETVRVLDEIVTEFIQGLAFEATRAANYAGRQKVKYEDFEFAFRKNDAFLGKVQEVFEKKGEIESAKKIFSKDEEVGLMKEVADQEQKKDKQPNGMVETPTAAETAAKQEEELGEADDDADAESEVAGRPAKRVRLDGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1W522</accession>
    <name>H1W522_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_00683</name>
        <name evidence="5" type="ORF">CH63R_01809</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009901">
        <property type="protein sequence ID" value="CCF47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161600.1">
        <property type="nucleotide sequence ID" value="XM_018296784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W522"/>
    <dbReference type="STRING" id="759273.H1W522"/>
    <dbReference type="GeneID" id="28860891"/>
    <dbReference type="KEGG" id="chig:CH63R_01809"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01809"/>
    <dbReference type="eggNOG" id="ENOG502QTQ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_1_1_1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="340" mass="37868" checksum="99569363DC2483A0" modified="2012-03-21" version="1">MAPNIVKYAKDQPVGFINRIEKVAVVGAAGTMGKFVTQELLKRGKHIVTAITRHNSESKLPEGVVTAKVDYDDEVSIVEALKGQQYLIITLKNTAGEDAQLKLIRAAAKAGVPYVMPNAWGPDPKNETLMSDTLLGTSFQGAVKEIEQLGMSEWIIMSCGYWYEFSLAGSPDRYGFDIKNRSITIFDDGNVKMNTSTWSQCGRGLAYFLDLKWLPEDENDTSPTIQKWANDVFYISSFLVSQHDMFNSIKRVSGTTDYDWKVENENSEKRWRAGHESMKSGDRSGFSRLIYSRIFFPSADGDVENTHGLANEALGLPEEDLDKATEEAIRLCLSGVLGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRL1</accession>
    <name>A0A1B7XRL1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150926.1">
        <property type="nucleotide sequence ID" value="XM_018308608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRL1"/>
    <dbReference type="GeneID" id="28872715"/>
    <dbReference type="KEGG" id="chig:CH63R_13634"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13634"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="763" mass="84459" checksum="62388D89F559D126" modified="2016-11-02" version="1">MAGEDDEFGLSVNEEEALSPNGESLTRRRSLASSNRGPRSKRAKYAAAACYECKKRKLKCVKSDTEAECQRCISGGVRCIFGPAPPQEDNAGVRENVMSRRKSRHNSQPRDDIRSELSMLREQVASLANTVGKLAANKSCQAPSASPGSQHHLPPHENASSQGAKEPKQPQFVGPTRSAFSLKVAETSLTKMGISANNTAAEPVNESLDPTRYPTPEQSEASQWVQGTDVLLTISLDEFVRLLEVFEEEVEIVYPFVDTRELVSKSAAIRAYVEENSDFTAATASTAPSTGVEIKDVILARIAVAISMVVESHGRNPTSNKLVEPVKQLIYQFSNDADVDLKVVQIMAMISIYYFFLDEELLAWRNIGIAARGALEMGLHQKMSLNDNFPHPEKRGLAVRVFWCVYVLDRRWSFGTSLSFALADRDIDPNLPEPSEDFRYLRCLIDYGRLCSKAWDALPPFGAPTQSIPKDTVAFLDFTAQSWLNSIPPDLQLRHPQHGGISTTQSRAVRRLRALLYLRGNHIRTMIHRHHVISSASIEADIEKARLVVDIAIDSISVLVHLSETSNIYERQQSAFNYFLLSALAVIFLAVCHGSRIFAEPCRQSFLVAVELVKGFSRQGTSSRRLWKSIRGLLPLAQRVGLRDDVNSAQGVDLNSRVPRHDPTDSSYILDTGVEERQSGQPVVMGPDLSHLPPAQPMSLNADFGTAAPDAFALSNDLMFLFDAFGQTDDVWTNGMQEYTGGDEQQPPLSGEAEISRHFWGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRL3</accession>
    <name>A0A1B7XRL3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_13626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150918.1">
        <property type="nucleotide sequence ID" value="XM_018308600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRL3"/>
    <dbReference type="GeneID" id="28872707"/>
    <dbReference type="KEGG" id="chig:CH63R_13626"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13626"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="520" mass="57396" checksum="BD8D941DB09EEE08" modified="2016-11-02" version="1">MGGLIIRKNIRNLSTAELDNLVRAFAAIQKLPAEDPNSFFVIAGYHGEPFRGAGYANPAWWGGYCNHGNILFPTWHRAYLLRLEKALQSQVPGVALPYWDETEEASLTGGIPPVFLTKDYKFADGSSIPNPLFSYKFQARITDRLTPIPDANYTKPVGYETVRYPFSGLVGTPLNAEGSFIHNAALREQGEEATNQMLNDNIVTWLNYSCFRNSDGEEVSAGIKAKYDHCLDAPNYTVFSNGTSAQRWNDDHLSDKGYKPVVPLESPHNSMHLAVGGFEVPGQGNSNQIAGANGDMGENDTAAFDPIFYFHHCFVDLMFWRWQIKNNQRDRLEIIEGYPGTNSVDAQGPTPGVAGGTWLTLDSPLEPFKKPGDPKTAYTSNDVINIARLGYIYDNVGEPPKAAPPRSRPSPVLTVGNINRATIGGSFVVSAWATKENGDKMLIGTEAVLSRWHVAGCRNCQNHLEVRAHIPIEGWSKEEAERMDFEVKLHTRTLKRGLGDGDDPQQGAQSPTVRLGTDHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XSP6</accession>
    <name>A0A1B7XSP6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151285.1">
        <property type="nucleotide sequence ID" value="XM_018308967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XSP6"/>
    <dbReference type="GeneID" id="28873074"/>
    <dbReference type="KEGG" id="chig:CH63R_13993"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13993"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="157"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="515" mass="57277" checksum="D1E919826C000AA7" modified="2016-11-02" version="1">MLHQQTASTLVNGSRLKLASSFITTSTTATVKSPAPSVRASSEDSVPRRSHQTMAAAAAPPAAPTATTRPPGTYFPLGYKDAVYQWWSSVTPQQAERNVLSHIPYLKEARENASLDSDKHDPFGPRVWKSQMVELSGKDRALNEYSIERVGEEVDNNLVIIHGYGAGLGFFYKNFEPLSRPKGWKLYALDMLGMGNSTRPPFKVTAKDQQGKTAEAEAWFIDALEEWRKKRNIDKFTLIGHSLGGYLSVAYALKYPGHLKKLILASPVGIPEDPYAVNAAMPEPEESTFQNEFTQDQNTVTNDDRNSMTSRASKSGAKNSNNAPKRPLPGWLVWLWDANVSPFSIVRFTGPLGPRFVSGWTSRRFNHLPPAESQSLHDYAFSIFRQRGSGEYALPYILAPGAFARSPMVNRIDGVGRQIIEKNGEKLKETGVPIVMMYGENDWMDVAGGYAAEEKLKQAKMQALLKGTDEEKRRENGSAKVLIVNKAGHHLYLDNASQFNDYILKEMEETQNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XTN5</accession>
    <name>A0A1B7XTN5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NPP1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR03108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151626.1">
        <property type="nucleotide sequence ID" value="XM_018309308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XTN5"/>
    <dbReference type="GeneID" id="28873415"/>
    <dbReference type="KEGG" id="chig:CH63R_14334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14334"/>
    <dbReference type="OrthoDB" id="5237073at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601057" evidence="2">
        <location>
            <begin position="26"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="386" mass="43467" checksum="FFDCC03235373766" modified="2016-11-02" version="1">MANFLSLRLRVILFLCFLSVSTVSCFKFENTAIHLNHGFKRGTHLKYSGDVGTQPQPSQAKPLFRRQPRKRSPVPRYPEPVIPWRKNDDAWSVRVEEPDMLYMNLGPAFDLSNCVFCPTQNDGTALDETDSEAILKHMTAQTFLRYIKGDKAALTDTCVFYSKGVTTAGAATGLSVAATEWACGESQKDRYTIWNLFPNSLDASSHAGVRDFYAMFTPGSWLDPVRKKQAEFEATKPPGIVPPSIRYFQQMSQSMAEACYGDIIIMTETPSELALYEPGKKYQDARFNNIFWSHERPVLQRKVRAGEAKLYALDSNTKEAWEVTNINTFELGPSRKFRRDLESGNETSDVFGRSRLEARANMCQGNGLASQGFGQDWFGSYGSNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU30</accession>
    <name>A0A1B7XU30_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151797.1">
        <property type="nucleotide sequence ID" value="XM_018307380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU30"/>
    <dbReference type="GeneID" id="28871487"/>
    <dbReference type="KEGG" id="chig:CH63R_12406"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12406"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="61" mass="6927" checksum="7F16FEE1003BD4BA" modified="2016-11-02" version="1">MHPTGLISYLYRSQRLPPRRLPPLLASSITACSHSQHSHSQHTNTYIHAWPVSNLPVADKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV18</accession>
    <name>A0A1B7XV18_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RasGEF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_12759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152150.1">
        <property type="nucleotide sequence ID" value="XM_018307733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV18"/>
    <dbReference type="GeneID" id="28871840"/>
    <dbReference type="KEGG" id="chig:CH63R_12759"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12759"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="335"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="568"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR03632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="823" mass="91879" checksum="4EC6F3E2E6B2CB3B" modified="2016-11-02" version="1">MESLNIAVIGASGVGKSSFVQRVLGLSRPPITNASSVRMIVDNVTYGVTLLELDLEYFELNPLQPIQWPKQINGHIVPRVDGALILYDVMKKESMKELPQTIAALTKSGLPAVLVANKCDHPESERQVDSQRVASHEYFKSCVGVFNLSTSSPERARACLNATLKAAIAYRKGKLSLGSRCTSQRNTDDQPESLSESGMSRRRAASAANLEAHDSSNGRPLSQQSKHSRASSDLSLLRGVPPPIPDHLRGPPPPRSPRIAEFGGAPSSSGSFGTSETIEEESQQTVSSQLRTPGIRLDRGPTDSFLDMEESDAESFRYSDEVPILQRSDESFLEKPVKSAGVAFDELVDRLIAPRMTKADNNFSDVFLCLYRKFAAPGELFSAILTRLDRVRDDKSAHYLSKTATQLRIIEVVAKWVSLYPGDFARSGTRRNLEEFIAHLSTEPIFSIAAQQIRRHLEHSVVEDDDTGWAKSDELADEEGSKVLSKDKTPSTPDVSNGISSLHLDDDKPIDERPSGSSDFSQVDRTSSVGTHVSFHSYDEYEREAANMEPTDVLPMNKFRYHIFMDISDDDIADEMTRIDWVMFSSIRIRDFVRHVSLSLDQRSKCKSLKNVNRMINHFNHVAKWVANLILLRDKAKHRAQMLEKFMNIAQKLRRLNNYNGLAAILAGINGTAVHRLSQTWALVPPESQKSFAKLGILMGTQKSHFAYRLAWENSPLPRIPYIPLHRRDLVSAEEGSKTFVGPDGDRVNWKKFEVLGEVLLPLMKSQGTAYPNLSKHEAARELILDCRMPTDEEEIYQRSVQVESIAGGGADMSKKKFPWFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVA3</accession>
    <name>A0A1B7XVA3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152204.1">
        <property type="nucleotide sequence ID" value="XM_018307787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVA3"/>
    <dbReference type="GeneID" id="28871894"/>
    <dbReference type="KEGG" id="chig:CH63R_12813"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12813"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="334" mass="35460" checksum="6D82E1D5B43763FF" modified="2016-11-02" version="1">MSNPGKGNPEPNVVIGRIGMRREGSLAPSVRAGFVLPPCPLCARRATARKLRASRWRRSGTPPIYLYIAVIKAATGLAGRTPCETPSRDGVQILASGQDVQHGGTCVLEAGGTAGNTTQSGHALRRHLGYAWIWGPCHGTGREHTINKSQPNLEKPIGSRPMSATTALTVLHVHQVPLHERAVACTGACLPSQQRHRQCSITPTASPGARLCFPIPIYIAHTRGADARPPARPHGADIPILAQTGARIFSCFAHLAAQVFSTTPSSSAVTPERTTLRSHFRAIASQHLIASPADRPNESAAAVAAKSPAVGSRPDSQRRRLPHGQHPLRGRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVR8</accession>
    <name>A0A1B7XVR8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152348.1">
        <property type="nucleotide sequence ID" value="XM_018307931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVR8"/>
    <dbReference type="GeneID" id="28872038"/>
    <dbReference type="KEGG" id="chig:CH63R_12957"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12957"/>
    <dbReference type="OrthoDB" id="5226911at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="266" mass="30053" checksum="3B14B973CB65B912" modified="2016-11-02" version="1">MAGFGDTVDSLLETYSICLSRLKGLKGSKHTRQLRKNIRSDQYKVRSAYSLRLAATGNNLQKGDAAARSSLEKVIKRLASAIARLVRPMRGQAPGIDYRSLQLLSNSSRVDAVKTIDDLSRRLGVSSRESTLSGSRATSKQRKRTNSLDKRKNKETSDTEFPRGGEKNEERQKAARVNMGTPARIQRMDTDKHMSMTTISSGSTKIGEIMPKKLRPRKPENWGANDEFTVQPTYPLRPYHQPEVKRRGFWGIFTRGRAARWRTTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XW19</accession>
    <name>A0A1B7XW19_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_13083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152474.1">
        <property type="nucleotide sequence ID" value="XM_018308057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XW19"/>
    <dbReference type="GeneID" id="28872164"/>
    <dbReference type="KEGG" id="chig:CH63R_13083"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13083"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR03956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="160" mass="17432" checksum="64C1ADDF63041A4D" modified="2016-11-02" version="1">MGVAGVPSGVERYQADGHKLCSTVRWITTLTLGSLVPIGEYLLDLQKNAVVERRFITRKAAPTANTPTRANLRCLGGYSVRGFDIDSAMTSALAMMMLKGKSVFKRDLDDDFTLESPWGGMVASRLITDTSDALLVTTPAALHGLLASEQLCWRGKLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXD6</accession>
    <name>A0A1B7XXD6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thyroid receptor-interacting protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_11125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152940.1">
        <property type="nucleotide sequence ID" value="XM_018306099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXD6"/>
    <dbReference type="GeneID" id="28870206"/>
    <dbReference type="KEGG" id="chig:CH63R_11125"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11125"/>
    <dbReference type="OrthoDB" id="4803341at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="201"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="409" mass="45454" checksum="4228FF07656232E1" modified="2016-11-02" version="1">MTLTTTTTFESLQQLTQQGDMLDTHKMADTAVTLGRTDDYILVSKPKKGIAYVEARLKDDRILLSRLEQEWSPPKLKDDTVISLEADLLKEPVFHKGVPSELFHSLRVVEFQGLDPTTRVVSMRDVAIKVNLYRCTPESPSVSDDEIVTMLPSSTLDGLWELLVLDHSVQSRILRWVNNYAMSRTTQLPLASSAASSIVPLLGPTGSGKTTLTKALAQKVAIRLCATHETIRLVEAGSRQPYNFNHFARGALEDPSCLHILIIDNVEAIAWSCKRPDAEQHMIETVRITSLCLAGLDVLRAVPNALAYATCSMDTMLDDGLLDRCSITANLTLLKAPERYEMLRRRRQACANCSSIHCASWLSTVTPFSRISLSAKPKTTTLAPRFFVWRELSEMTPSPGLWPMSSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXT8</accession>
    <name>A0A1B7XXT8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153083.1">
        <property type="nucleotide sequence ID" value="XM_018306242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXT8"/>
    <dbReference type="GeneID" id="28870349"/>
    <dbReference type="KEGG" id="chig:CH63R_11268"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11268"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="261"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="455" mass="47325" checksum="56C434EC3A322284" modified="2016-11-02" version="1">MSTITQAKSIELTDRGRSDSGLVGPKNQSQAADDSEVARAISDREAPRNATEAIPDGGYGWTIVASNSMLLFWINGYTTAWGVLQTNMLRSGLLKTDVSTITFVGSLYMACMVAFSLVSVRLMGAFGVRYTTLAALSMFSLGLVATSFTLEHVAGLFCVAGLFVGCGGSLLFTATNTLPIQWFSSKLGTANGLVKAGGGVGATVLPLAAQALINNVGLPWTFRIFGLLTLVTGVPCVWLLKERTRIGTASRFDWSMLKDFSFLTLTIAGGIGVFALFVPPFFLPLFASSIGLSSAQGAGLVAGFGASTAVGRLFGGWFCDHIGAFNALSVSALINSLSMMVIWPVSSSLPLLAVFAVVNGCANGSFFVGLPTAVGLLTPGSAAASISLMTSFWTPGYLLGAPLAGILINATGAAEASSIEPYRAAIFYAAGVGAAASGLIIVSRMRRNPRLLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXZ8</accession>
    <name>A0A1B7XXZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_11314</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153129.1">
        <property type="nucleotide sequence ID" value="XM_018306288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXZ8"/>
    <dbReference type="GeneID" id="28870395"/>
    <dbReference type="KEGG" id="chig:CH63R_11314"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11314"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="528" mass="56973" checksum="E5098B19DA38BB94" modified="2016-11-02" version="1">MLDFLRKKSSESESAPPPPETLVAPRKPFRKAIIPVIACGAGLFSDGYINNVIGSVTTVLALQYGDLYKTSNAKKYVGDIAFAGTVVGQLAFGWLADHWSRTNSLLVSTVILVVFTALAAGSYFKGDAVGMFNILAAWRFFVGIGIGGEYPAGSVGAAESTGELKSGSRNLWFIMFTNTMIDWGFVIGAFVPYVVAAACHNSHYSTIWRTSLGIGVVFPIFLFVLRLFVKEPEEFTKNSMRYAKTPYLLSLKFYGWRLFVVSLIWFIYDFSAYSFGIYSSTILSNLYGNTAPLTTVFGWNTVINLFYIPGTMLGAPASDWLGPRYALALGVFLQAVVGFIMAGDYFNLSQPGMVGGFVVVYGVFLALGEFGPGNNIGLLAAKTCATGIRGKYYGVAAAIGKIGAFVGTWGNSIHVSGGARSRWLTHPFTVFPYIQAAAGDDAVASAQYPFWVSSSLCVLSAALAVFCLPHIGQDTIAIEDARYRAYLEANGYDTRQLGLKRGESVESADERSPVEGLSETTKGEKTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY39</accession>
    <name>A0A1B7XY39_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153211.1">
        <property type="nucleotide sequence ID" value="XM_018306370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY39"/>
    <dbReference type="GeneID" id="28870477"/>
    <dbReference type="KEGG" id="chig:CH63R_11396"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11396"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="346" mass="35870" checksum="422C487AD73F071D" modified="2016-11-02" version="1">MAQDPPTEMRRWQVASPGAFIRDLALVTVPTPAASSLKANQVLVQVIAAGINPADYKFPDLGLVAKAIISFPRCPGMDFAGRAVAVGSAITDIAPGDVVVGRLDPMSAQGSLSEYAIANRDGIASIPAGAASVDLEQAAALGTAALTAYQTIVPYVKAGDKVFINGGSGGTGTYGIQIAKAIGCHVTVSCSTAKADLCRSLGADDVIDYKTADVVADLRARGKVFAVVVDNVGNSPPNLYKASDDFLLPEGHFKFVGGAVSLAQAKSLVPGLLLPAFLGGAKHKFEVFVTKNSHEDLARIAAWVAEGKVRTVVDSTFEFEDAVKAYEKLKQGSAAGKIIVRVAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY40</accession>
    <name>A0A1B7XY40_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase family M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_11372</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153187.1">
        <property type="nucleotide sequence ID" value="XM_018306346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY40"/>
    <dbReference type="GeneID" id="28870453"/>
    <dbReference type="KEGG" id="chig:CH63R_11372"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11372"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="8">
        <location>
            <begin position="522"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="728" mass="80031" checksum="46CF71EBDEDA8900" modified="2016-11-02" version="1">MTPALYNAEAGGSVCTTPACLQLSSYILSSIAPNYTDIDPCTDFDKLACAGWASTHTPIAGRAKASSLGEIRNAVNIVLRDVLEGPYPNGPNAGFLTASLSQEQVAIDRDNFKLIVDTYNACLNNTAVQAAGLRPLIGLINRVAEAFPVADTTEDRERKVSKGDASNIGKALLLFNQHGIGTFELIDVTLDDQNPNQTIISVLPGGTPGLSDSQARNNQTVEEYQRIMAAVLQEVHPSKLTASYAQRLAVAINKFERDVSALKSKDDSRADDNSPARKFKLEQVTSVAPELNHDFVLKNLISADYELKELYFSPGYFGNLSQLVTNTSVETVQGFFMWKMVLTFSGYVEAEATERLNNFKDKIRAADPDVVGKAPRWQQCVQHVDEGVPWSSLPSGLGWILSRFYLDKGYSKESRELATNMMGSIQQAFISRLGDKDWLSSEVKKAAEEKVNAIVKKIGYPDMSPDTANPRNLADTFSGLQLGNAYFDNAVALAAFAGKKTFAQLGKPSDKAIWLQTPSTTNAYYFATYNDIIINAGIQQKPLYSPEYPAYINYGGLGMVLGHELTHGFDNNGHNYAANGSLVNWWDEKSLQAFTNRTRCFADQYQKFTVMAPNGTEVPINGNFTLGENIADAGGVVTSYAAWKKSQADKKSNNMDLPGLQKFSHDQMFFLHYAQTWCEKATKEADVYQIVTDVHSLGFARIKGPLDNSEDFRAAFNCPQKQATCSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY87</accession>
    <name>A0A1B7XY87_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153230.1">
        <property type="nucleotide sequence ID" value="XM_018306389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY87"/>
    <dbReference type="GeneID" id="28870496"/>
    <dbReference type="KEGG" id="chig:CH63R_11415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11415"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF9">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="595" mass="66857" checksum="10B45748F214D16F" modified="2016-11-02" version="1">MAEEPTVAKPTLPSLPTEILLDIAELVSDACGRAGLARASRRLCEVANPTLWRHGVQDNLSKMLVQASTTGNLDILKKSVIYGADIDVVHPVSIPEEAKKCYPVPILREQEKDYLFWAAPLHLAVYHGHYDAAKWLVSHGADIEAPGHLFCECKGYRDYLGDGSNITIGSCWTPLHYSICREENSIIRLLLSAGASIQTMVDPDKIGIDDRFDKILQGLDPEVLRFRCTSLSSNVTALHTASEKGMKWLVTHLVRNMQVNVEVTDNSSMTPLFYALLSTDPSMIDNLVWLGADLRWKALDGRTPLKLAFDCNLWQSAARLQDLGAKLDTDTRRPWTDLVHYIRYSTFGRRTLPGLPDERVNLLCYEKEDRKHKAITRLAHSLRDDCLLMTKSGYEADINHTSEDLGASAELPEINCLAVAFMAIIEENWCGTKILESFLAMGVELDKDELARRADGGMNLGFIALKAVTGRNYSPYKIRFLLQNGADPTNKWRHNARAETPLRNILYALHDWVLSGVEHACETRSFQTMIEVANDIGRHGAWDSPYAKERAKLFGILENIEKTSGLSPRQLRLRNQLRDNLIVPYHLKEPQQDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYR6</accession>
    <name>A0A1B7XYR6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl-CoA hydratase domain-containing protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_11593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play a role in fatty acid biosynthesis and insulin sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153408.1">
        <property type="nucleotide sequence ID" value="XM_018306567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYR6"/>
    <dbReference type="GeneID" id="28870674"/>
    <dbReference type="KEGG" id="chig:CH63R_11593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11593"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052377">
        <property type="entry name" value="Mitochondrial_ECH-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43602:SF1">
        <property type="entry name" value="ENOYL-COA HYDRATASE DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR04890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="337" mass="35677" checksum="BFEBA2FC4BC55888" modified="2016-11-02" version="1">MPVDRGFFNSEPPPMQFPKLPAKAAYLHLKNPTKRNALSLEILEDLRTQLLSHLTSRATGRLLALPAFNPSILSELEAASGHAESGSGGSSKHSWLVDAAEWKHQRDGLPNVIVLRSSGPVFSSGHDLKQLSSLSDVEVRRTFALCAEVMSLIRRSPAPVICPIQGLATAAGLQLALSTDYPIALSTTKFQLPGASIGLPCTSPAIAVSRRLPPGQAYRLLLSAEAVTADEMRGAVDVVPTPDHAESTDTAAAAFEGRVAEVVERLAGSAGQPMALGKWAYWTQLGIRGDGADEGGADGYEEAASWAGGVMALHARSADAKEGIAAFTQKRKPAWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYX2</accession>
    <name>A0A1B7XYX2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gpi inositol-deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153470.1">
        <property type="nucleotide sequence ID" value="XM_018306629.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28870736"/>
    <dbReference type="KEGG" id="chig:CH63R_11655"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11655"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146583" checksum="3E1A149C8FE4C309" modified="2016-11-02" version="1">MKGPTMTMAPAVVEPAHASYLHRSHTSDDRPDTAPSGTTSTATTRQRGPSVHGRAAFELPSFDTIPEFDTTLYLDGKGSKEAATPKEKVMPGPVAVRTTRSDPVKPSKPSRDEDKENTREGKQREKDMEKLQKRGRRTSLMERRKSWLPSSRSPSKIKEPPLPERPVMPERPSTHAGDHVGAAASSATPVLPTRPVEPERPRTVSESFATFAKKSWMSTSRSPSPKRIPEPPAPPLPRPSRSRASSNDSIKTAEAARKRPISMLVDPESAASKSAESLKPARTLNRTSTFLTKMKQRPKSMLITLGSGSDSDVNSAPVSTNTLPPPGVAPVNDQRSKKDNHNNIVNNIKKPESKPASVTDSQTTAVTDESWSEMSVNKDTIWSAFRTLDTECGGLATKTMAQRMHMVRVTLLPFLRTYMNHTTNKGLSLEDVERRAIVLNKWWSGLLEMLDSQNQQLAGVDRPVLLEALTMLMMRPEWRQTTTYFMSLADRSPNERVRPRSGTQSTADSSQASSQAFLAESAEHNVRTMFVGNLMKQMQIVVDKMSLRHAPLSLVNWCGKACAYGFFFCPSVAEILVRLWDLRPELIRRAADELGLPKKNSGESEDIMALFPPNLGVLGWQSQKTISARFKERVKLSVMAARIPWFSPWVTRWRGGDTDLFFIFCKYYHILSEEFMPDGLPLLEKARSPGFVLVQAQILACIESTIHRQAEVDAMMNPLPPTDSFYGADAAATSMTVPGNLLKNMAENRLIVLLKDILGESLPVIAAARRTFAEAFLAVTRAAARRVSAFDHSAVFTLCDFLEEALVAYDQLDDLENPNIASGINWSFWLDACRKMLVSDNAMTEVRLLSFIFSTWEAVTANPERKRIVCLDWLLSEETFDTYFNHWCPMVRGYYMRLLCWRICRDSGCANEVDAQIFVAAAARLKTVWAHYLYIRNTADAAGKLPPSTSPCLPTPGKKFMIIRTEVNIPQPGYFNQPFDSFAKIVNGDGVVATATPPEPKEVVAKADNSKKRWSLLGKVLSLGGNGSDSEDNSDTSRKEASSKPATISKRRQGGPPLPPKISTSTASAIATSSDGSSPGASPIFMEQKFVFKFTLTWQPPAVIQPRDRILTRPRLPAPAQAWVSARSRSGSTPPPMPAGLPDPTRRVSGSKKKGLVDEAKNASPLASPTLERKSSVTTVSSSSLARRLSNKFDFENNPDAELMTFDFEGAEKSSASSMSSASSTASSPVEGKTEDEQPLSPPSQPQSQAQQQQKSESRRNGPEPLTQPLRPTGMYTKRAVYTGRALAEWSLVVAECNGFVDRRRDEGVLGLSEVEVPMLTVEGFRKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZ03</accession>
    <name>A0A1B7XZ03_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_11664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153479.1">
        <property type="nucleotide sequence ID" value="XM_018306638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZ03"/>
    <dbReference type="GeneID" id="28870745"/>
    <dbReference type="KEGG" id="chig:CH63R_11664"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11664"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR04961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="325" mass="36873" checksum="F10D4AC9CCAF6C04" modified="2016-11-02" version="1">MLRQIKPRNARSKRALEKREPKAQENPKTALFLRGTSCSQVTQDALNELYQMRQPLAKRFVKKNDVHPFDNTDSLEFFSEKNDTSIIVFGHTSKKRPNALTMIRTFGHKVLDMLELYLDPETFRTLAQFKGKKVPIGLKPMLVFAGTAWDSPIANEYTHARSFFTDFFRGEQTDKIDVEGLQWIVSITADEPTAAGEGDVGGAKPAIRLRAYTISTKRSGSKVPRVEVNEIGPRMDFRVGRMREPEEAMLKEAMKKPRGTEERTKKNITTDGMGDKMGRVHVGRQDLGDLQTRKMKGLKRSRDVASEDEGEKGDAEEKPKKGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0N4</accession>
    <name>A0A1B7Y0N4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154096.1">
        <property type="nucleotide sequence ID" value="XM_018307255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0N4"/>
    <dbReference type="GeneID" id="28871362"/>
    <dbReference type="KEGG" id="chig:CH63R_12281"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12281"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="238" mass="25295" checksum="2C6BFF460B3A812C" modified="2016-11-02" version="1">MTTQLVAQAEACSAEEVLAFLNGQNNLPAVKGAILVKLSTKDHNDQLVVLDPTQPGSPSTVIINVTRIAPDAGANSTTANPDADAVPVPAGPHAGADPIPASRPKVTFKLLDVESRTIAEIQATKPTSNNSLSLRGWRLSVSLSSSSYSQLAISTTAPSGSNSSGRTGYSNTPHNIADCTLRIERLIEIKPKKEGDPSTWEWEFFLAVDVRVLVNQGTLASPKWHQVVEDLSPSHNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y112</accession>
    <name>A0A1B7Y112_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154227.1">
        <property type="nucleotide sequence ID" value="XM_018304803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y112"/>
    <dbReference type="GeneID" id="28868910"/>
    <dbReference type="KEGG" id="chig:CH63R_09829"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09829"/>
    <dbReference type="OrthoDB" id="3789824at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="174"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="677" mass="77012" checksum="07EDF37D340E3B9E" modified="2016-11-02" version="1">MVTASPDDYCSACHDFDPQGPLHERDAVLRDTFGIHRVALENRTPAELRRRRDDCYRCAVLLAAAYKLASDWDKMTIWLEDHQNPKISLTGKDACSFELYTTEADSPVKHLHPLLEVPASPRSEATMDFMARQVKDCHDNHDKCKINHEFMPKRLIRLTEKGGHIIHPDEPVPYIALSYCWGGDKNIRTLRANITAHMDSINLGHLPRCFRDVAVIAPRLGINHLWVDSLCIIQDDHADWEDQFPRMSWVYKNASVVVAAAAIGNCQESFLGDGEDDERMRRPESFVISDAHPSQPAAVRARAVPTIGLHEDLQSFYSARDPLDCRGWPLQERLLATRILVYSRTELQWSCQTLQACEGGHTSSPNHPFTPLITIDTAEKAFSLWHSQVMEFSKRRLTFETDKLPAISAVAGHVADVTGSRYIAGLWRDNLIRDMCWERHMFESLKWEATRHWRAPSFSWASVAGNVFYNDNSIAAKGFYLSQVVDAGATRQSSPVFGQVVDAWVDMEAPLIEATLETHPPYDGSDLFDYNNPGAMFPHGHPETLFLAKVGGWQIPFRGDTHLAPGPIRPTPREPAHGLGNTAYRVRDLDSVELSPPVTVWVMIVGYWWEYTNKYPNGQRWLTSIVLGRSERQPGAYERLGYKNQPWPPWEKIPQEDFDRINAHVHNEGEKQHFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y1R7</accession>
    <name>A0A1B7Y1R7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154482.1">
        <property type="nucleotide sequence ID" value="XM_018305058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y1R7"/>
    <dbReference type="GeneID" id="28869165"/>
    <dbReference type="KEGG" id="chig:CH63R_10084"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10084"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="135" mass="13942" checksum="4E27F08AD2D6E6B0" modified="2016-11-02" version="1">MLNTRAAGCSSPPRCPAKPSAPAGRGDSIPLLEAVGFLRGAGDETHAGQDADGAVDTPEADDSIHCASTGQRGVSPEPSRRAHTQSVVFELVCASSYGCGWAPLFRNVGTPRVVELAPDGGRLHLIRRPGGGRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y2F7</accession>
    <name>A0A1B7Y2F7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_10294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154692.1">
        <property type="nucleotide sequence ID" value="XM_018305268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y2F7"/>
    <dbReference type="GeneID" id="28869375"/>
    <dbReference type="KEGG" id="chig:CH63R_10294"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10294"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7587" checksum="E96749A9C6E145A6" modified="2016-11-02" version="1">MYFNVDNIVILLPSIVEPAEDVLAIYRDTIRVGVDECAGDMEHGHHILYVFRFFECMEVTRKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y378</accession>
    <name>A0A1B7Y378_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aurora kinase 2 splicing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_09689</name>
        <name evidence="1" type="ORF">CH63R_10607</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155005.1">
        <property type="nucleotide sequence ID" value="XM_018305581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156686.1">
        <property type="nucleotide sequence ID" value="XM_018304663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y378"/>
    <dbReference type="GeneID" id="28868770"/>
    <dbReference type="GeneID" id="28869688"/>
    <dbReference type="KEGG" id="chig:CH63R_09689"/>
    <dbReference type="KEGG" id="chig:CH63R_10607"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09689"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10607"/>
    <dbReference type="OrthoDB" id="5150797at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR06487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="352" mass="38825" checksum="8BD694452EF95909" modified="2016-11-02" version="1">MISSTYDPCLLLPSDDNADFGIVGMQTDDTIGLSDSLFDAREGDELAKASFSAKPKTYLSADEKLLFNGGIVAMASSDSTVITQRQKGQGTKLQLIDAKSPTAKQDYVQQRARGAYIASICQPEACFDLSTAAQQQDPTDEDIKNLNRRIEWQMKSLDRGLTFVPLDLASAKLFVFVDGSFANNRDMTSQLGFIIILGNEEPINGHEDAFTLTGNVVHYSSTKSKRVTRSVLASEIYGMVAGVDMAYAISSTLAMITKKLNLPPIPTIACTDSYSLYECLVKLGTTQEKRLMIDIMALRQSYERRELYEVRWIHGDDNLADAFTKATPNQALENFITTSSAQIRMEGWVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3E2</accession>
    <name>A0A1B7Y3E2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nad dependent epimerase dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_10666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155064.1">
        <property type="nucleotide sequence ID" value="XM_018305640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3E2"/>
    <dbReference type="GeneID" id="28869747"/>
    <dbReference type="KEGG" id="chig:CH63R_10666"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10666"/>
    <dbReference type="OrthoDB" id="3526284at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="291" mass="31759" checksum="6EE5B21ECDE92B25" modified="2016-11-02" version="1">MSKALEGGGDPPPPSYSEATTSNPSSSSYNPGSSVSATLEDLSSLLRVTQSQQTARDTITTTTLLPLLTPHVTSLLNRLGRTPHPPALTELYLVPAAAVGPQWSITSDADRRAGEVAQVIRVEPEPDLGSKGAGDSKRAVPDAGLSAASSSRDYEFDEWGRWDDDDAAASTPKEGWWWWNDEALARRLAKLLQPEPRLDRTVVSAVMEQAKEERKAGGWGMFRSGTESPSSSARPLSRQAQPDRSTPLRQEEDVAMTVRAGEVTFRKENEMGIWESMRGYGIVVRVRIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y3T9</accession>
    <name>A0A1B7Y3T9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase esterase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_10817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155215.1">
        <property type="nucleotide sequence ID" value="XM_018305791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y3T9"/>
    <dbReference type="GeneID" id="28869898"/>
    <dbReference type="KEGG" id="chig:CH63R_10817"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10817"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="365" mass="40272" checksum="4BCB3FB26BC1630D" modified="2016-11-02" version="1">MPRSLKSIALAFVRPALDALVFGRHLPWPLRWRLLALQPIVFLTNSLAVGPYLFRRPYTVIHIPLGPERSLRALLFRHASGTGTGRNGLRPLHVDCHAGGFVGGVPEASVPFCSLLAAETGAVVVALSYRLAPVHPFPAAIDDVDAALAWLRRHAAEELGADPTLMTVSGASAGGNLVLAASQGIPSDEFAIRAAVTFYAPVDLRPRPEDKPRPAAFPKRDPMSFMQLLYDSYAAPSREKDLDNPRLSPCLAREETLPERMLLVVAAVDILVQEQLTFVERVRREREDKRKPGGSVEAVYVEEAFHGWLEGELAISTPCHKRLADIDTVPNAVIPVEKKMQMWEKGLELIKQTHAQHGFAWKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y442</accession>
    <name>A0A1B7Y442_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_10898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155296.1">
        <property type="nucleotide sequence ID" value="XM_018305872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y442"/>
    <dbReference type="GeneID" id="28869979"/>
    <dbReference type="KEGG" id="chig:CH63R_10898"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10898"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601301" evidence="6">
        <location>
            <begin position="21"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="119"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="575" mass="61384" checksum="06DAC82AAFD35497" modified="2016-11-02" version="1">MKTSAVIATATLAAAPFVAAGLLPKRAEDASCRCLPGDDCWPSTASWDALNSTVGGKLIATVPIGSVCHDPNYDEAACTALRESWTLPETHFPSSSSVMQSYFANQSCDPFTDRTTPCLLGNYVNYAVEVASAQDVVETINFARDNNIRFLVRNTGHDHLGRSTGAGALAAWTHKLKDITVTDWSDDLWNGPALKMGAGVLGYEITEAGKSSGLVVVGGECPTVGPAGGYIQGGGHSALTTNFGMAADQALEFEVVTADGKIVTASRAENPDLFWALSGGGPGTFGVVTSVTVRAHPDASVGGVGLQTAASYTTQEKWWQMLDAFHSLLPSMTDQGAMVVFLYSSNIFAINPLTAYNKTADEAKAILQPFLDVLADLAIPYSSGATSYASYRDHYDKWMGPLPYGHVEVESYNFGSRLVPRDVLTDDAARAAYVSAIRYGADKHGVLSAGVALNATAPAGVDNAVNPHWRNAAIHVQYSTAWSNAPEDWAQMVADQKTMTEDIIPPIEAATPGSGNYINEADFNIPDWKEKFFGGNYDRLLTIKKEWDPQGVFYALKTVGSDAWNVAADGRMCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4I8</accession>
    <name>A0A1B7Y4I8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Eukaryotic membrane protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_08436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155433.1">
        <property type="nucleotide sequence ID" value="XM_018303410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867517"/>
    <dbReference type="KEGG" id="chig:CH63R_08436"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08436"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="922"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1285"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1324" mass="146820" checksum="025548FE16F67B30" modified="2016-11-02" version="1">MAESQRSDDRGADDNHGASGNQAAVPSEPVEAFPPMPTFILEGSTAYDHDGGPLSQDTKTDIKVSHIPLPPLPSASASAPPTSTLPTIPGGHSDEDQSSDVSSTHSKPEKQDSSNSSSISEPATAAEKHEAESNEGVAPKTRVRAGSSSASMRKNQSHDNVRRLSVAGMQQLTAPEALPVAIVPDQASSAERDQRARSAIADQLQAIRQSILSQPASLRPNGSVTDGANSSRQDEPRRPVSARTLSTPPTTRRQSQSQATSPRRNSFYTVARPPPLNLDATSHFNAVNLQPPTQNKPPQIHVPPPSTKSLRNDPIPPSPLPPSIPLPPMSIPTHLQLELAAQRPSPLYIHHSHTNDIPYESYVVKWERLKNVLLLPSFLERTLYFGALACLDAWLYNFTILPMRFCIALGVLFKWWGYMALKEARWMIGFVWYGMGRVWARARRPRAKAVSSARQEAAHHLASRDSSRSRPAERRPSIPALDLRSPDGAPTLHSDSDSKANGHRVTEHEVKGNGNGHITHKLNASAGHHPSHGPGHRTHRHRRTKSIPSNLSSFHKADLLQGAVIICSSMFLMKLDASRMYHFIRAQDGIKLYVIYNVLEVGDRLLSALGQDIFECLFSSETLSRNSSGRSKVLLPLGMFVLALIYNVTHSVALYYQVITLNVAVNSYSNALLTLMISNQFVEIKSTVFKRFEKDNLFQLTCADIVERFQLWIMLFIIGMRNIVEVGGLSVPGAGSENGDLGGSGAMPLHSPSILPFSFTILPSWVWSGEVLSPFLIVIGSEMLVDTIKHAYVNKFNNIKPTFYSRILDILCKDYYTNAFVSPSLTRRLGLAVIPLSCLFIRASVQTYHMFLSTRIPTPIPESTQTSLSVESATPSSPVMVAALDRLDTLLRDALGRAVYGYPYGEPSMQSRAWWTWTSDDVIAAVTMIVVFFIAFLVLLIIKLLLGMVLLRYARNRYAQMKRKEHLVATGQEERQVYDAKGKRVGGYSQIEITEDRRRWIHADEKEGLKGGKGRFPKPEKPPEGEYMGVQRLRIMSLPPPLTDLELLARARGLSNGIPPNEREVRLLASELSVCRNILDKLVEESSCSICYRPLRSMHVIECGHSFCTECIRNEFKENGMSHDIHVHAFCPACRLAIALELNEDKKLHVPDHIMANDQLPYLRLWAKLRRVTDEVYSAHGIPIPETAYSWRRQDVETHYKTRAEEEAEDNKVWVNTGEAGENGDQENFDDQENVNDQEGEGNFEEETQNPTVRALEAFIALATATVPSPQRGSYNTYMDPPYFPSALGPGPDQPVLHDVTHASTINHHPPETDEVAPGEGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y593</accession>
    <name>A0A1B7Y593_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155695.1">
        <property type="nucleotide sequence ID" value="XM_018303672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y593"/>
    <dbReference type="GeneID" id="28867779"/>
    <dbReference type="KEGG" id="chig:CH63R_08698"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08698"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="457" mass="52772" checksum="9651AE2790292CF5" modified="2016-11-02" version="1">MDTPTCPPPRDDREKEILEKLVAIRDRLQLLKQDRTTYIRSQDVLPLYDETIEQVRQLNECRSSDRREENRVDRVLESCFQLLSLFFMTIGRNNEAPAAYALTSTIRRLLDHLTEVDLYSAKDLESLSHTLTKLAHNVKSTENEYSPYIITLLSNRLELCEKSLANLRKRLERLEDPLPKTYEKLISILRSMSLANTRSKFSSSEVQKLQAQLREIDEQSKEGKFVTADGKAPAGGEEMAALLEKCLQWSDVVLDRKGVIPDSFRPTYDVLFRIRNELEKLSITQAWSLREADLFDFQRQLDKIDESRVNGNWLDDEGKPAELYVQRTLLYLIRRSYAYIYSLMISSEPVSEALLPIYNQLQTLKRCLIEVKNSGGVQSVRELYPYSMKVPYFSPETGQETRLTVSQLHSIDNMRQDGKFMINNDIPEGQGSVSELLAECFELNYELRVAAEEQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5N6</accession>
    <name>A0A1B7Y5N6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">60s ribosomal protein l20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155845.1">
        <property type="nucleotide sequence ID" value="XM_018303822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5N6"/>
    <dbReference type="GeneID" id="28867929"/>
    <dbReference type="KEGG" id="chig:CH63R_08848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08848"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="214" mass="23952" checksum="A69945E0699EA51D" modified="2016-11-02" version="1">MEARTLTRPATALATLLRQQTASAVPRRGHKTFSRTKRSLNIPPHPDFLPSTTPASGDTIIYNPPSAAPSVFHTPFKFLPPSDPRRRANLSSLFANSNSSAAASSQTSSSARPLPPALNVPSRGANPRYHLTRDNVAEIRRLRAEDPDFWSVTALARKFDCSETFITICTPAPREHKERLQRKLEGVKSRWGAIRTKAREDRTRRKEMLFRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5W6</accession>
    <name>A0A1B7Y5W6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155902.1">
        <property type="nucleotide sequence ID" value="XM_018303879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y5W6"/>
    <dbReference type="GeneID" id="28867986"/>
    <dbReference type="KEGG" id="chig:CH63R_08905"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08905"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="79" mass="9011" checksum="6A14FB139385C12D" modified="2016-11-02" version="1">MTDKSRVVECMPQTPEEGQASNAKEGDMTYEYLDGKVRVVHGRLRRLERIVAAVVAQRGDEQADWWKGKRADDFELVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y628</accession>
    <name>A0A1B7Y628_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10.e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155970.1">
        <property type="nucleotide sequence ID" value="XM_018303947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y628"/>
    <dbReference type="GeneID" id="28868054"/>
    <dbReference type="KEGG" id="chig:CH63R_08973"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08973"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="221" mass="25237" checksum="642AE4CD36B17FF3" modified="2016-11-02" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKKATVDDFPLCIHMVSNEYEQLSSEALEAARICANKYFVKTAGKESFHLRVRAHPFHVVRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQIIMSVRTRDSNKAVALEALRRSQYKFPGRQKIIISKNWGFTPLRREEYLEKKAAGRVKVDGAYVQFLANHGSLEQNMKRFPDAFASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y784</accession>
    <name>A0A1B7Y784_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156407.1">
        <property type="nucleotide sequence ID" value="XM_018304384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y784"/>
    <dbReference type="GeneID" id="28868491"/>
    <dbReference type="KEGG" id="chig:CH63R_09410"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09410"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="192" mass="22117" checksum="025FBC6887603FB1" modified="2016-11-02" version="1">MAANKATRLGEEIWKTRIDKVNAELVTLTYGTIVAQLCKDYDSDYAEVNKQLDKMGYNIGLRLIEDYLAKSNTMKRCANFRETADMIARVGFKIFLNITPQVTNWTTDNKQFSLVFDENPLADFVELPDDERAQDELWYSNIFCGVLRGALEMVQMQVEAHFISDVLRGHDTTEMRVSLVRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7V2</accession>
    <name>A0A1B7Y7V2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase s41 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_09637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156634.1">
        <property type="nucleotide sequence ID" value="XM_018304611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7V2"/>
    <dbReference type="GeneID" id="28868718"/>
    <dbReference type="KEGG" id="chig:CH63R_09637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09637"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601408" evidence="1">
        <location>
            <begin position="21"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="2">
        <location>
            <begin position="346"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="752" mass="82309" checksum="AFFCA2427AF2D834" modified="2016-11-02" version="1">MKSVLALASAALAAAHTSTTQSPCAVVASQLAISSTAEIPAINAFNCLNSVPVDTEGNSELIDELKQLWQFHSEIVWLKNPGSDWEYGPLDIMDELDKIKANLESYESEYAVQLAIQNLTVRTGNFHFNYQPDILSVFIFRRRFNVASISSDGKALPKLYFDNDVAALADGDDGVFDIQSINGMKPYDFLQANLYSQYINSDGRMNNMFAKGDTNRPGAFARQDKYDGNSTDVVWSNSKQESFSNYAITRQNFKGVVDGKTFFETFCTGAISGAKSSTSADKDKEVISPGILGPVPTIPTGSYYLSSRTKKRQSIPSGGAYASAVAESKTGTVAGYFLTDSGFSDVAVLKIISFSNPDEDKFDETLFNNDFQATIQSFLKKCIAQNKQKLIIDLRENGGGNTNLLIDAFMQLFPDMDPFSGQRYRATDVFNKIGDVVNEVYTNSDLATKFQTTTGQSIVTGFNFRYWAWWHFRNAEGDNFDSWDEFNGPHTYNNDKFTTTFRYNYSSADRVSVLPDGFNFVNGSRPTAFQPSNVVMFTDALCGSSCASFHEELKNIAGVKAVTVGGRPENKPIETVAGTKGGEVIPLIRFSQYAKLTLQFSTTAGLSSIQSNNATLSAVANVPNIAIRVGDSFTRAQSQDQIRKGDETATPLQYIYEAADCRIFYTAKSYADPVEAWKQAWSAYSDNSKCVEGSTGDKSSISGGYKPYGSAQVQPEDEPLAYVPTSGENAARSTQIGSLGIALFAVLFAVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8E8</accession>
    <name>A0A1B7Y8E8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_07096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156849.1">
        <property type="nucleotide sequence ID" value="XM_018302071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8E8"/>
    <dbReference type="GeneID" id="28866178"/>
    <dbReference type="KEGG" id="chig:CH63R_07096"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07096"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="378" mass="42850" checksum="5B24D29F62CF14C9" modified="2016-11-02" version="1">MATGQLDGMLRRDARFLYEIWAWFAAGAVVIFLRFVVRLRMVGPAGLKGDDYTMLVTLFLYTLCFVMVDLVYRYGSNVDLTAAQISVLSNEEVARLVQGSKFQQVAWYSYTAYLWSLKATLLFFYKRLTFDLWQNAKVLRYLTWFTIASYLAVVGTITFSCLPFSDNWGVRPLPSEKCVFKPQNLLVTTFLNVLTDAAILSLPQPVLREIRVPLYKKVFIAVLICSGLFVIAAAIMRVAVTLGSEPSTITVNRWGVRECEVGLMAINAPILRPLFSRRFWQWNYRPPARTPGPMESTRRSRTAAFGRRRRVFKDGSFLAWMNSNTSRLGTAVRTQGRKSPVDLELGDAADDQELEPLDTIEDDEEGESFRSVTDKGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9G7</accession>
    <name>A0A1B7Y9G7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157103.1">
        <property type="nucleotide sequence ID" value="XM_018302325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9G7"/>
    <dbReference type="GeneID" id="28866432"/>
    <dbReference type="KEGG" id="chig:CH63R_07350"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07350"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="65" mass="7161" checksum="E013D02FF4343482" modified="2016-11-02" version="1">MTAGTRIFMGNHIWLAKRGDEQSAAGRQAAQQDSGSERANRNMHASAREDDNDDDDDDTSVELSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9N3</accession>
    <name>A0A1B7Y9N3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_07459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157212.1">
        <property type="nucleotide sequence ID" value="XM_018302434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9N3"/>
    <dbReference type="GeneID" id="28866541"/>
    <dbReference type="KEGG" id="chig:CH63R_07459"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07459"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="778" mass="83858" checksum="8DD955359D847F10" modified="2016-11-02" version="1">MAPMTPRLKILSGMADDSELMKTCVVGGNPVSAFLSWRLQATNACDVTLVWKSGFDHVAQYGISFKSPVFGNERFKPRHVVRVPEEAAHGGGPFDYVILCIKALPDVYDLAAVIDAVVTPQHTCILVNTTHTLGVEAAIEERFPTNVVLSLVSNAELSQLGQSEFEHKGSTEIWVGPSSKNENIPGAIQGDMAEALAMTLNTAQVDCKVSHNIRQQQYERVVGPIAFHPASVIFETAIHAQLLEKVGVRDLVTGVIDELLALAEAHGCKLPPDFKQKTIDDMTKPTNPESIMWQDYIAKRPMEVETYLGSPIKLAKEAGVPVPRIETLYAILHNLNIVNRQRPPKPVDVTMAPPGSPTSQSPLPRTASSNGIRPGMNGNGMPPNRGPRPRNSSNLGPGPGPGMRRPPMNGGPPNGFPRGPPPPGSRAASRRGSLEGNDLEEFSHLMHYDDIPEGGEPGYGHGPDGSDLAVRERELELRQRELAMREREMRMRSRGPPPGPRRGPHPMRNSAQVFDEEDDDDDYFDPQTGPPPPMIDPDNFDMMSVTSRKNRKAAPPPTRAQYHKNEVYDAGGAPPARSSRFRPNFGRNRSSQISSVPGANENILDDPLFSYSSNRYGAVDRSTMQAGSRANSLTASRMDDMQLGGGPMAAGANGAYPRRASQSPGNPYSPSIRGGSGRPSPPNGYHGPPMNGRPSPPDGMRQPVPRYPPGHGNAVAPQQVEQHIGVSGLVPPPKQKNMRSLTGSASASAGSGESQNDTEPSAHSSQSSLGQRPPIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9Z2</accession>
    <name>A0A1B7Y9Z2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GATA zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH63R_07530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157283.1">
        <property type="nucleotide sequence ID" value="XM_018302505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9Z2"/>
    <dbReference type="GeneID" id="28866612"/>
    <dbReference type="KEGG" id="chig:CH63R_07530"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07530"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="679"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="961" mass="102041" checksum="D8E9738DBAE5C5A9" modified="2016-11-02" version="1">MAASTVSPIATRSPFTSMNPTTTEHDFRFPRRPDDHYGGTSHSQAHSKASPSDLPAGLRDLRLDLSAALYPDAHDELLKNSDFPPFQKATMDSYKSPEELQREDPLATQVWKFFSKTKHMLPNQQRMENLTWRMMAFNLRRKQQEEEKARLARSAPAPAPPPAATPAATFSANPPSGIAQLRKSSEQNVNHSDPMNLDDFIFSDNLATPVTNPSPLPHKLEERSQHQVHSSFSSAIPIKSRKDPALQQQFVPQSVPFPPHHQRTHDEFNYVTRHHRKTSIDERRTRKRPADFSPHVPAVNSTTTTTNDLDTDSELHEYSLDNANGSNMSQNSHQAGVPFPLDTYNIENDPIITSAGPFQQNFSFSPSSSPMISHGPFSTAYNASSVQSSSLNPSDFYSPPGSAYHSTVSTPHPMPDNDGFYFGSMDVRSQRQQSFRQGPQSIGNQMNGQFMYNTQNGNPMFPASAPAAESVSAFSAAPSPFGHIDPTQVFQPDHPVRSPGMSMPNEGMFTFGADSDEEDGGAFADRNLVMSQDFSPGPMDDSNSLGWDPTLPGQYSTQAARYPGGPPRKQVTIGGTTTDYVETNDWEGGSLPRSQSFRQGSDRRGGKVPRTASTPAGHLGRNGNPFDRMAQSTPNSPPENNGTVSGYSSVAPSRPSSPPGSKQGSTTNLQAAAGSQGEGNAPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGSGASLPVGGTSTRSKKSATAHASGPGSRKNSTLAISTPANHVTTPPAATRASSANEGESPASGAASGGNTAGSTPTSYGTGSSTGAAAGGKGVVPIAAAPPKNTPGPGAAALARNVGTSSSSSSSKRQRRHSKSAGSEGVANMDVDSPETSMGSPNEAAKSLGSATGLASMPTAGSLGLANGFGMTQRPMMGTGMMGMPSGQNGQMMNPGGPTSGPQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA42</accession>
    <name>A0A1B7YA42_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157382.1">
        <property type="nucleotide sequence ID" value="XM_018302604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA42"/>
    <dbReference type="GeneID" id="28866711"/>
    <dbReference type="KEGG" id="chig:CH63R_07629"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07629"/>
    <dbReference type="OrthoDB" id="4848842at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="507" mass="58055" checksum="8CB265C743A6F28D" modified="2016-11-02" version="1">MDLDALLHDWRRERDLNRRRRPCALLAWLQDTWHDVGSYLNAQACILLFQKLFFRDVFLTTAFLVWVGRRAVVRNRWLFGVLASAGFADGEVGSKLLRAAAQSSSAFAVHLALASLVFPLVFWRSPALPIPGDRHLAAWDVLAPLARTAANWLGARKGMREWRSLAEDNPAFFCEAGPADLFSMYTTFSHYAALILVVRELAHTFDGYQSRAVEEAGEAVGAVEAEGGAELTAFKIWVYRARFLFWELLMQFAISVAFELIADAAGSLQCWCIQSGMKLPDRLPAWVRRLPFLGCFFSLHFALRHPTVSWAIDQVHMWVFPEEHQHEDEDDWDQDDWEGSDWDDGDEDENDEEGDERGDDNREGDDEEDDDEEDDDEEDDDGEDDDDQDNTSDTDEETDDRNEDEDEPDHIYIYKDDCGYVFEVKDGAVFERETLFTYDGEYKYEYRYTDDRQEVSAHQRATENEYKFRHTCRRKAQEDRDGGGGGGGCGSSHDERPEGSGDESQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAJ3</accession>
    <name>A0A1B7YAJ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157638.1">
        <property type="nucleotide sequence ID" value="XM_018302860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28866967"/>
    <dbReference type="KEGG" id="chig:CH63R_07886"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07886"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601476" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1328"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1260"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1291"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR09121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1448" mass="156414" checksum="19DA9931235089C2" modified="2016-11-02" version="1">MVIIITSICIRIWMLTLLPQIDERDLNLLPPTRKFTHVLNPPPQVERNKHKHKRRYIHYNQQNDTDERRSLHCLHYIALPYIIRGHRTSLLDLFNFPTRDSLHPRNWIVVPTIRIQCAYSLPELEPAKQTVRVPPPPARKEYDNSDPRLAGNAIEPETMDVASESGGGLSKLLPRAIVAKRRRRKQEAREDDAAAATAAMLLGVKGEDVTAPVDAPAAPLRDSYSYDYGDGDDDNASYLSTRRDSGSYVHDTDTLSNKDISTGFPDFDYQHFREHGHDAAADEISTKATNSMVTLDESDADHWTISNLVLFPPLSRSSFRPNAISTHPSQIGYLTTSSPIVQASHLPEPQSQILDDQLPEIASARSTTSINSAKRTQSVESTDSSLRSKRSFTGLVPPKKTTTRSPSPVGRRLKGVFTKSKKSPSAATSPERSVVGGDDTDDGRDTRRTRDRGRASASASTSDLISTSSATTKQPTLDKHSAPQPNATNNAGASRVNSTTHSPERRRSRASTTTSRIDTSFVPQTPPNPDKATPVIVNTPPTPTDHNAPFVQSPPGPPPQPVVEAPTASGNTNGGSATGNMIAHRRGRSGSGSIGPSKLSNITLAPLTPTPENGTASNPGTPSAGGFFSSVFSAAQNAATSLTSTIQNTGIGPPPSKSKNVAKLPDIRIDEQPEVEPPPPSATGSTMEKEPAVKTIGSGELSLSQLGITDTGSAAGTPITAKFPESAEARVRSESAPTDAAYAAATRDLGVDDGKQATRPQSLYEPGSGGDHTPPQGSIHEDRNSGVQRSGSIRSAIGRHRKRGSSAVSGGTATTVGAAIAAANASVAHPQANASVPKLTGFAVASKKRNRDFHTLFKSVPDDDYLIEDYSCALQREILAHGRLYVSEGHLCFSSNILGWSTTLVMSFDEIVSVEKRSTALVFKNGLMISTLHAKHIFASFTSRDSTYDLIVNIWKLGHPTLRSSLNGVQLEGTGGDKTEKVDVNDAAAPEVDDGSLSGTDEESESGDDDDDVYDEDDDADDLQDVTQLSEVNAEPEGGKTVSRKVSGAGANGAVADVVKDAVGVPSGGDDFPGPAAHAPTDCGDSDTHYERVVGDDVIPAPLGKVYNLLFGPASVTWMTKWLTVEAKCTELQMEDKKGLTLENKSRYFTYIKPLNGAIGPRQTKCLVTETLDHLDFEKGINLSVTTQTPDVPNGNIFSVKTKYCLTWAENNSTRVQSNCTIEWTGKSWLKGPIEKGANDGQTQYCKDLFASLKSAVSTKVRTGGAGPGPKGKKKSKKSKAAGSATDAEDEQVRPRNVPKKDWGPLEPVRGILEPILDIVKPLMTGNMMYGILVGLLVATWFGFGLPGRQASGDVRMYGYPDRLAAYDEMWRREESELWEWLEERVSLERLHDGNLPTRKRAIEPSTVEERVREDRMDDREIQEAIKVTEEKLKVLKSVMDKKKPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAN3</accession>
    <name>A0A1B7YAN3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157466.1">
        <property type="nucleotide sequence ID" value="XM_018302688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAN3"/>
    <dbReference type="GeneID" id="28866795"/>
    <dbReference type="KEGG" id="chig:CH63R_07713"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07713"/>
    <dbReference type="OrthoDB" id="5346740at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF3">
        <property type="entry name" value="EXTRACELLULAR MUTANT PROTEIN 11 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="2">
        <location>
            <begin position="355"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="491" mass="55099" checksum="468CB20640075364" modified="2016-11-02" version="1">MPPSSGANQMAQYAKNASLNSGVPNENDDQSKQQRSDTPQFFTHHTRQAITESAKLPAPKPLAPARALASHIRRPNQSGLGLPQPPLPAPMHAPPDLPDSSPPRQQRQRTNSRTSDATGFWPESQIDSQFGSPTTHRSERFDVGIGNRLRSPPPAMPMTSSMPNMPIFGNMQQSLEGDIPYIIGKDGSMRLLGNGQGQDLPVMHNGMLPSQMEEQAQDAYSSEPIYDTPGRRAPKITLHATTVRRSYEPSAFKDGEGVFADSPTRKAPRPQQNLKRIVRNDQAQESQRPALFQEDEEVEGSLASDYPVSEGDHGTPRAKGTNVVPKERTLQESPLPATTRDQRDKSRKRRRNSCDYADDELQGMTYSQLREQPFDDDPAKTSLRPVGPLTDDSLPVKLEHFKGQREADQKEFFKQMTVSDWERSGDWFLDQFSQVAQKLKEARKNKRDMVDRFESEIASREEAVRVRTENITKKLNKIKHKGEDMLADKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAW0</accession>
    <name>A0A1B7YAW0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CH63R_07860</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157612.1">
        <property type="nucleotide sequence ID" value="XM_018302834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAW0"/>
    <dbReference type="GeneID" id="28866941"/>
    <dbReference type="KEGG" id="chig:CH63R_07860"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07860"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="536"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="488"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OBR09095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="773" mass="84129" checksum="91CC8456BAB18ECA" modified="2016-11-02" version="1">MPVAEGNPQTLYDKVLQAHVVDEKLDGTILLYIARLTKDLQQAFEGLKNAGRKVRRPDCTLATTDHNVPTSSRKGMKDIGSFIAEDDSRIQCMTLEENVKDFGLTYFGLGDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLITKRSKNMRIQVDGELAPGVSSKDVVLHAIGKIGTAGGTGAVIEFCGSVIRSLSMEARMSICNMSIEGGARAGMVAPDDITFEYLKNRPLAPKYNSDEWHRAVKYWKSLQSDADAKYDIDVFIDGKDIIPTVTWGTSPEDVIPITGSVPDPETFSTENKKAAGRRMLEYMGLTPGTPMEDIVVDKVFIGSCTNSRIEDLRAAAHVVKGKKIAANIKRAMVVPGSGLVKTQAEKEGLDKIFESAGFEWREAGCSMCLGMNPDILAAKERCASTSNRNFEGRQGAGSRTHLMSPVMAAAAAIVGKLADVRKLAGYKASPHIEAAITPDSEPHVDERVQESDSEKEAIADQPQDNEPHTNTSVSAGTSAGLPKFTNLKGIAAPLEMSNVDTDAIIPKQFLKTIKRTGLGKALFYALRFNEDGSENTDFVLNKEPYRNAKILVVTGPNFGCGSSREHAPWALNDFGIRCVIAPSYADIFFNNTFKNGMLPIIISDKEKLERIAAVARSGNEVEIDLPNQLIKDSDGNTLSTFDVEEFRKHCLINGLDDIGLTMQQNDKIADYERRMSQLTPWLDGTGYLKRDPKTGRLLAKAVPVPKTNRGETKTEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YB05</accession>
    <name>A0A1B7YB05_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NDT80/PhoG like DNA-binding family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_07825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157577.1">
        <property type="nucleotide sequence ID" value="XM_018302799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YB05"/>
    <dbReference type="GeneID" id="28866906"/>
    <dbReference type="KEGG" id="chig:CH63R_07825"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07825"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601484" evidence="4">
        <location>
            <begin position="21"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="5">
        <location>
            <begin position="236"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="236"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR09060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="672" mass="73856" checksum="B00FB5E2D6A52F51" modified="2016-11-02" version="1">MRYVQTSLFFLCLSRSLSLSHFPCSLPGLQCLGLVNSVSFPKSSDACCPGQDHKPRPSKNPNSTSFVERQDLLPGAFFPALYGSIHWAVMSRKRKEHSEEGSRVYTRADSHIRYEHNSNASLSTIEGPSQQPTALLNLFNPPITNATSYSPEGGFYHTAASQIFPSLDVRPRLGSNNISSTGMAHAHRSTALPHPGAHITTRDQYSPARPSYRRVSEHQPRSPSYPAALRRHPISPTTSPITGFTGPAALRMDSGHYTSPSSRVQTSVPPLSPITDLGILQHTDGTQVKVDIHGNIDKGFFQSDGDWTCYRRNYFSCICSFSLNPHYPGQSLQFTQQGSTQSYSVRGFAMSISAVVAENDSHTIELVQHTPKRDKGPVEKPGKVHLHPKHPQMSHPMGIYHPDTVLGGPSRIGFSENATYGGQQSGDPYQTEHTFERIQFKQATANNGKRRAAQQYYHLLIELWADVGSQVPDKFIRVAYRKSAKMIVRGRSPGHYQSERRASTSSGPGGSGGSFTGYPNSSIMGSDFGPAGAMLGGGYGASFDSRGNAPYGSTRHHHELEHMLPPEDSKAIDTTKEYQYYPGTMYDGTDSRGGVDMFTHHRHGQDNMVPHVGSNYDPLHDRVKRDPEILPSIFQPGALMSNQRCGPFEGKPTSSGYYPTMPQSGVNVTNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YBR0</accession>
    <name>A0A1B7YBR0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipase esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157805.1">
        <property type="nucleotide sequence ID" value="XM_018303027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YBR0"/>
    <dbReference type="GeneID" id="28867134"/>
    <dbReference type="KEGG" id="chig:CH63R_08053"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08053"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="150"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="371"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="822"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="875" mass="95768" checksum="A60E0F0F3341B254" modified="2016-11-02" version="1">MNPLKLNTTSVSLAVTPTVVSTLFSHYLNRKATKQRPDAHLSYDEGLHLVRSFLEFASQHTVEELQAFTAQWVPHPQWVKVEDAEIPETHIERSAGLIEAQLGPAGVRAVGGRKWWTWRRPQSPLKAEWVEMRADYHERKKNGGATKRVMLYIHGGAYFFGSVDEHRYQMQRHARKLKARVFAPRYRLAPQFPFPCGLQDCLAAYLYLLTVQDPTTIVLAGDSAGGGMVLSILCVLRDQGIPLPAGAVLISPWVDLTHSFPSVSGDNELDYIPSCGFHHKPSRAWPPPNEDDMEMMREQAIKARAGKEKSATKLNSLEKKQAAPIALDEEHGAPGPEGSPESSDNADPLKTALQISVTINGELVTVKDQIQFQMYTTNALLSHPLVSPVMQPTLGGLPPLLIMVGGGEVLRDEQVYLAHKCANPAKYPPPGLDEAGLAQMKQYKPTDVQLQVWDDLCHVAPTLSFTRPAKHMYRAAAQFGAWALARAQQTEIEILDDDDISQISSSASDSESHRQDQTENPYPLEQVGKAGMPLPPFKKHMIRQRIMTNGVVHDLAPESQLPGCVMSSEEVGVVKGTPVRRWLDAKAQFDKKFSSAKAKVHKGIIKDLADGYIDFGDGEKPPPTALAGRRKASDELIDRKKTKSFGLALWSLWGSKHDETTMERERKADSDAKTSASQVSPRGGEGARPFQDVGDQQPPSVGSPGSKRRIVMDENQVSQTSDSQVEISQATEVEDTPVASLIEMRKEQEKQNEEAASAAGRLSPDFVPGTGVAGKRPFLDGIALPFSLGKKDAETASMVTLMSGGDSRPISPMPPMSRADTSDFNEASASEATTQVAEAEHTRPTLDNFVTAAEDFPLSKGKGKEVANGNIEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCH9</accession>
    <name>A0A1B7YCH9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_08315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158067.1">
        <property type="nucleotide sequence ID" value="XM_018303289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCH9"/>
    <dbReference type="GeneID" id="28867396"/>
    <dbReference type="KEGG" id="chig:CH63R_08315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08315"/>
    <dbReference type="OrthoDB" id="5243981at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF4">
        <property type="entry name" value="VON WILLEBRAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G01160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="317"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="695" mass="76991" checksum="809A9EC5BB53452C" modified="2016-11-02" version="1">MPMGPNHALTPRAPSLQQPQSSSDTDIPNDCLPLLHASVVVNVDGNITRTTLLQRFSNPSEQSIPEARYMFPLYDGAVVVAFRCTVGQERELFGKVQAKEKARNTFEKAVKRHETAALLEEHTPEIFETVIGNIPAQTDIEVRIEYLGEAKISVLDHTGDVIDINIPMSIAPRYGKSSSFPENTSTMVNREGLSIEVKVTDSGTVKKLHCNHQVKIEKNVPFNPMKASSLAELSKSDVRASSSAVPPPTQSVIRYASDVAIMDEDFVVSVENNPSHPLRSRAVLSPSDENGLAAVMINIKPAEIFKRATRADRFAGELLFVLDRSGSMGSLDYRGRQGNTGRTKLATLKRAMPLALSSLPETCHFNVVSFGSDAEFLWRRSMPYTNENLDFAQRYLQRLEANMGGTELLHALKKAVDSRRAEQSSTQIILVTDGEVQSDSILEFVWNTRQELGDKIRFFALGIGFQVPHRLINRIGEFGGGYGEVVDIEAKPKWEDRLIVMLAAGIGPKSWNCTIDLGEGFERQSLMSDRFWDESTRQEPEEPGIVPFIQAPYPIPPMHPFAFRSIFLLLDLSSGSPPTKVILSATKDEAKPATEHVLFLEPTKTDTSTIQHLAAKAALLGLEAEVDRQIPNRRQEELAQKNAVALGINYAVISRWTSYVAVEDSTGVVDEVDLCKAVFLQGELVDFIDSFNKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEP7</accession>
    <name>A0A1B7YEP7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158891.1">
        <property type="nucleotide sequence ID" value="XM_018301041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEP7"/>
    <dbReference type="GeneID" id="28865148"/>
    <dbReference type="KEGG" id="chig:CH63R_06066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06066"/>
    <dbReference type="OrthoDB" id="5376010at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="706" mass="77496" checksum="39B0B897BCA530C8" modified="2016-11-02" version="1">MSRQQGSQEPSSNISDIDVQPNSPAPAGGDSNNNDNGNGNGSLSDVWFDSLARKFAVEEHEEYLREQVRIELGAQEREAAWRRDQAELLNPQPQQLPSQQPPLIIGAPLGRDLTAVEAATRLVSQWEAIHEATLASTPEGASPVHEELTEARAQLAALTAQHEQAASSPSSRLLSEEETQNPMTTPLNSLDAHKSAAVDARIRFLVGSLEDSHFPPERANIAAAVSLYRTARIPYSANWAILYAGHLVDFAPTYASLTADRAARLDRYARLHGEGWLWLEPPLAREPGGPTFFSARKGTFLPESDNSYDMGHYSVTMSFRRMKSLVYRGALVTNMSRKRKHDRVARSSDDEGTMLNEDDWPARFPDIDSDTTDDGDGPGEDEEEGQTNPLPSSSALRAGIKPATRLRRNRPSRHPLMASDRAAPTLHFRMLLDSGATLPLIYDRDARTLGIRRRTYAAVSRVTVETASDQMATWLYEMHVSVADTQTCEPLVSPTSPVWPAEEHALGGVTLVMTRPSPRLDGVASFSSPCGGMNAVAKTEPGGEAAFLEAARTLVDIAEGRDYGRLSGLLPFKVCYVQSTPGLRTMWVGEDRRDVLGAQRMPGQMRWAPGTGRVCDPGHPRDLWKTLCRNGGGNPALLRMAHEGSATGDGGEPGARLVDVEEQGWKGRSEVLVVDKTGTRRKHIIEPRSLKRQQAEKQHVKRQARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGM7</accession>
    <name>A0A1B7YGM7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159649.1">
        <property type="nucleotide sequence ID" value="XM_018301799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGM7"/>
    <dbReference type="GeneID" id="28865906"/>
    <dbReference type="KEGG" id="chig:CH63R_06824"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06824"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039510">
        <property type="entry name" value="Vint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032838">
        <property type="entry name" value="Vwaint_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF156">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14623">
        <property type="entry name" value="Vint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14624">
        <property type="entry name" value="Vwaint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="81"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="741" mass="80037" checksum="04872BCC7458B449" modified="2016-11-02" version="1">MVKKWFSRSSVEADPALVSRAASTKSDISTWTTTSTIQEGDTLSEDGVALSIHPLPSKDGLIAKITPPKQPVKPIVHVPCDIVLVIDVSGSMGCNAPVPANPGEETENYGLSVLDLVKHAARTILETMDDGDRLGIVTFASKAKVVQKLTPMNKKNKALAEKNINGMRPIDATNLWHGLVEGIKLFNAGGEVNTGRVPAVMALTDGMPNHMCPVQGYVPKLRGMEQLPASIHTFGFGYSLRSGLLKSIAEIGGGNYSFIPDAGMIGTVFVHAMANLQATYAINATLRLTFGASVDLEETSGDSVVKQEALTLPDEDGEPKQLSICLGNIQYGQSRDIFLQVTTTGPEDLTPQGSSIKAVVEYSRMTSTVHRQTAEQSLLVPTTLPESEIAYHLSRSRICSYLSSIIPTREDGEHEAKSHISLAVREQLDSLIRDLPANKFPSDPQNRSLIEDLAGEQPKGQISLALTNREYYSKWGTHYLPSLLNAHTRQICNTFKDPGPLRYGVDSPLFMACRDRLDAAFDNLPAPTPSNEHMATHRGRVKMSSYNSSSGVCFVSSTPVQLASGLTVPIRALRRGAAVQTPSGRRRVVAVLKTPVRREMMCRVGSLVVTPWHPLSLDGGKTWVFPASVAERPVRYTGCIYSVLLQPDRDPNAHAVNVAGCWGVTLGHGLVAGQDARAHAFFGDYGKVMASLRTLGVGRKGVAVGGGVVRDPRTGLVRGFKSHKQREGVTVRKWKKVGCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YH61</accession>
    <name>A0A1B7YH61_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_06850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159675.1">
        <property type="nucleotide sequence ID" value="XM_018301825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YH61"/>
    <dbReference type="GeneID" id="28865932"/>
    <dbReference type="KEGG" id="chig:CH63R_06850"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06850"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="497" mass="56589" checksum="06480EADC067F5BA" modified="2016-11-02" version="1">MALFSLGLLNTLGLVIGLAIVYYLGSVVYLLFFHPLAKFPGPIWMRISRAPFCYKLCVGSLPFDMLDLHKKYGPVVRIAPDELAFHDSRAWKDIMGHKTQSGAEMEKSVRFYRAVPNAPADIVSSGREEHSTLRRSLAHGFSERSMRDQQPMIKGYIDLLIKRLHEHGANGGKALDLAAWYNYTTFDVIGDLAFGESFGCLDGSDYHPWVKAIFQMARVGTVLQTGTHYPFVLKLFMALIPEKVKREQSQHDEFTEAKLRRRMDLGQERPDLLEGLLRKKDEWNMSFAKLKANSSILIIGGSETTATLLSGATYYLLMNPDALKKLTDEIRSTFKDESEIDFQSVSNLPYLLACLEEALRLYPPVPIGLPRIVPKGGANIADHYVPEDTTVSIYQWAMYHSEKNFRDPFGFHPERWLQDPAFATDNKEAFQPFHVGPRNCIGRNLAYVEMRLILTRVLWNFDIKIADDSTDWAPKQKIYLLWEKGPLNAYLTPVQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHB9</accession>
    <name>A0A1B7YHB9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_03580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159801.1">
        <property type="nucleotide sequence ID" value="XM_018298555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHB9"/>
    <dbReference type="GeneID" id="28862662"/>
    <dbReference type="KEGG" id="chig:CH63R_03580"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03580"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="304" mass="32298" checksum="74A6C49E0C4877D8" modified="2016-11-02" version="1">MSLSKVKHIVLVLSGKGGVGKSSVTTQLALSLALAGHSVGVLDVDLTGPSIPRMLSIEAEKVKQAPGGWLPVPVHEAVEEKGIGSFHAMSLGFLLPRRGDAVVWRGPKKTAMVRQFLTDVLWDETDYLLIDTPPGTSDEHISLAETLLRDARPGQVAGAVVVTTPQAVATADVKKELNFCVKTGIKVLGVVENMSGFVCPHCSECTNIFSSGGGAVMAQEFGVPFLGTVPIDPQFGELVESGRRPEYPQGTQVHGHDMSKTETGSDGQSKGDTLVEKYQDCSLSRIFNDITTQLTSTVESQAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHC4</accession>
    <name>A0A1B7YHC4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159994.1">
        <property type="nucleotide sequence ID" value="XM_018298748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHC4"/>
    <dbReference type="GeneID" id="28862855"/>
    <dbReference type="KEGG" id="chig:CH63R_03773"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03773"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="460" mass="51231" checksum="73C5778DD844B7FB" modified="2016-11-02" version="1">MLLDLLARERPPHPDVLMIPTPPLQQTALFIVFFFPALSVFTFGLRAYGRLSTRQWGLDDWLCGLAVLFAVLMTPPFFMFIKLGYFGWRAVDVPKDHDMKAALWWNFLVQMFYNPVLALVKASVLVFLLRLGGQKQGVRLAIHGLNVFNACHAVAIFFAALLQCLPIEANWDFSLRAEPETKCIGNSFHVIASCLTIFSDVLVLALPFWIFLGLRMPMAAKMAVIGVFLMGIIVTVVAVIRVVQIYKLFFVQPPPGTDNYHDIGLTTSTIEVNLAIFSACVPALRPLFRRWMPKLFGGGTTDKKSARTDYYDGYATGSRQKHAGAQGEDDIILREMRSKGHRAEIRSVSPTGSEEGIMAYNGIVRTTNVKVHYESHGSVDGSRSSTDFKSSEVPAKGVSSDWNRLNSLFPQGTFRESPKSQSRSGSLKALILFANCVCYDKRGLAPRSPEHNLNSRSQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHE4</accession>
    <name>A0A1B7YHE4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restculine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159993.1">
        <property type="nucleotide sequence ID" value="XM_018298747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHE4"/>
    <dbReference type="GeneID" id="28862854"/>
    <dbReference type="KEGG" id="chig:CH63R_03772"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03772"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601669" evidence="3">
        <location>
            <begin position="24"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="655" mass="70835" checksum="AEB51D04B6753B81" modified="2016-11-02" version="1">MPSIGRALLFAAAAMPLVNFVGAQHIVVDGETVDANEATVAPAAEEFPEADIPEQAVQLTDAVLANLTQLELDNISLFAFADSQAAAEKRAEPNNKCKTFPGDALYPNELVWKVFDLLTGGALIKTVPLGAACYAGEHYDAEKCQYLLDNWSNSDTHDEHPTSVMSPLYQGATCQPQNAANNGTCELGGFPLYSVKATNVAQIQLAVNFARALNLRLVVRNTGHDFLGKNTGAGSLSIWTHNLKGVKFVESYKSAGGYEGPAFKLGAGIQVSELYEAADREGYTAIGGECRSVGVTGGYLAGGGHSPLSPVAGLGSDSILSVSIVTPDGRHITADDKTNSDIFWAVRGGGGATWGVVTSMTVRVYPKTKFAGLTWSVNTAEKNISSATFWSAMEAYWRRFPDFSARKTYGYSTVFPAGNGAFLWSMRPFLVPNVTLTEFKALVEPLFTEWAALGFAVEPEYFEHDNFYATWKNHFPLESVGTAEVRTANRLIPRANWEDPALLDETIATLKGIVNDGSALIQYNINAAAPADATPSAANPAWRDALMFAIIGGGWSPTATRDELRAVNLRITQDWMGRLRAITPGGGGYGNEGDVMEPDFGQAFFGSNYARLYALKKKIDPWGVFYAPTAVGSEDWYIARQEDWLTLQTDRLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHQ9</accession>
    <name>A0A1B7YHQ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat containing protein yar1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_03892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160113.1">
        <property type="nucleotide sequence ID" value="XM_018298867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHQ9"/>
    <dbReference type="GeneID" id="28862974"/>
    <dbReference type="KEGG" id="chig:CH63R_03892"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03892"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="228" mass="24086" checksum="DF118C5FF81F1340" modified="2016-11-02" version="1">MAEGTVPPHTSLENFYLSLKTHSDPQTALIKISAKMAPKLSEEEIDDLIYLSRAGELAELQETLKTLSERENASVGEVITAAKDEGKSTCLHMAAGNGHIDIVKALIAALDARPADEKKAYVDAANEFGNTGLHWACLGGHLEVVKVLMAHGASPAAANDKDQIPLDSALFNGKREVADWFLAQSETMEGGNREDGLSGAAAGVEIEDDGEEAGEKTKEEAGEGSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YHV3</accession>
    <name>A0A1B7YHV3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH63R_03955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160176.1">
        <property type="nucleotide sequence ID" value="XM_018298930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YHV3"/>
    <dbReference type="GeneID" id="28863037"/>
    <dbReference type="KEGG" id="chig:CH63R_03955"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03955"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601692" description="cutinase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="14">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="411" mass="44974" checksum="2187C60FA679DF3F" modified="2016-11-02" version="1">MKFFIVVMSVLQCAFALSLPTVIVPKSHFGEGDQHTHALQVRQNPVLVENEARDGKCKEIMFFYLRGSTQESNMGEQPGPQLAEYLRQTLTAERIAVQGIEYAAALLDNACVNNQLCRPSEVTSAERQIRQYMDKCPEAVVVAAGYSQGAAMLSSVISNANRLEKKYKDRITAVVTFGSTMQIYNKNTIPNFPSDLVQMFCNKLDPVCRAGIPLGAALPGHRDYRKSAKPAAEFLVKKLAAAKAWPSVPVIADIDPSKFASMGLNFRDIFRGASKGTSDAFNDAEKLGSLREPRLVNVYGRGGARVDFLGVAVDGVADVLEHGGKGGDYKEMRLDEGEFWTKAEVCNGQKKGKDRIGYFRAESSKGKKMEVGKRTNQCQKYVAEKGGYFVGLYGEAGTEIDSLGLIEHVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJR8</accession>
    <name>A0A1B7YJR8_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH63R_04566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160787.1">
        <property type="nucleotide sequence ID" value="XM_018299541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJR8"/>
    <dbReference type="GeneID" id="28863648"/>
    <dbReference type="KEGG" id="chig:CH63R_04566"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04566"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="415"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="772" mass="89017" checksum="75500863A81ADE8D" modified="2016-11-02" version="1">MSTAKMAPAVQMPPVPNREDIGATWKYLEAGIQRIMLDLERGIDMQIYMGVYTAVHNFCTSQKAVGLSVPQGSIGSGNHRGAHLLGEELYNKLIDYLKLHLGGLVQQSKTHTDEALLTFYIKEWNRYTIAAKYIHHLFRYLNRHWVKREMDEGKKNIYDVYTLHLVQWRRVLFEQVSTKVMEAVLKLVEKQRNGETIEYGQIKQVVDSFVSLGLDDTDPTKSTLDVYRFHFERPFLAATKEYYQNESKQFVAENSVVEYMKKAETRLEEEEERVRMYLHADIINPLRKTCNQALIADHSTLLRDEFQVLLDNDREEDMARMYKLLSRIPEGLDPLRQRFETHVRKAGLSAVEKVASDAEKLEPKVYVDALLEIHSQYSGLVTRAFEGEAEFTRSLDNACREFINRNEVCKSGSNKSPELLAKYTDVLLRKSGSGIEEGELENTLTQIMTVFKYIEDKDVFQKFYSRMLARRLVHSNSSSDDAETSMISKLKEACGFEYTNKLQRMFQDMQTSKDLNVSFKEHVTSLGINKNALDSQYSILGTGFWPLTAPNTSFTPPAEINEDCERFTRFYKNRHEGRKLTWLWQLCKGEVKAGYCKNSKTPYTFQVSAYQMAILLMFNDKDKHSYEDISGVTLLSSEVLDQALAILLKAKVLIVSPDGKPEAGKSFRLNYDFKSKKIRVNLNIGGAKEAKQEEVETNKTIEEDRKLLLQSAIVRIMKARKKMKHTQLVSETINQIRSRFVPKVSDIKKCIEILLDKEYLERLEDDELGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJU4</accession>
    <name>A0A1B7YJU4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_04643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160864.1">
        <property type="nucleotide sequence ID" value="XM_018299618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJU4"/>
    <dbReference type="GeneID" id="28863725"/>
    <dbReference type="KEGG" id="chig:CH63R_04643"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04643"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="252"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="518"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="777" mass="85331" checksum="670C46FE42DC7516" modified="2016-11-02" version="1">MAKTIDGKVRPLAPFDKTLEKSTLKGASRIYVNRDSLIQLTGSVDNGRRCVVTRNVAQDAAKSTSTTEPLHREAALWTLSDKNISPNIILMSEAYREACGFELGDQITITMCEKTVIPDAEAVNILPVTTSERERAEISAWEGAWIGVIRFYLGRAEHVFPGMKFECVAPGAKQMFRITTVDGQTDNVARYVVSTIPSIVSSEEEEEPVQEVVRDVTRLVVSNIPGLHAEEKRLRSFLRGFNTNFVYKGQQKSCGIVIHGGRGTGKSYILSRIAATGWGRVFRIEENDKSSTVEEIFKQARTMQPSIILIDGLQALIGKDRANSTAIIQRLGQQLDQLAEDAVNNGTLPKVVVVATCLDYMTDVPPELQKRTRFERNIPLSIPNAEGRLEILKSFDIPVQPEVKDVMLVKLSQQTHAFNASDLDRLIENSMIISAERLDPDETGYDEETMGTPYLSREDLEQALRSTRPTAMHDVNLKPPTIHWQDVGGQESLKKALRNMITLTTTNDPTVQKLILTPPKGLLLYGPPGCSKTLSAQAMATESGFNFFAVKGAELLNMYVGESERAVRQLFERARAASPSIIFFDEIDSIGGQRAGGGAAAKSQGSVNMLTTLLTEMDGFEALSGVLILAATNRPEAMDPALLRPGRFDRIVYVGPPDAAGREAVFNLYLRKLPLAADVDVAELSRLSEGFSGAEIKQIVNVATEPALNKTLNKTSGQGAADGGARLDGGEMAQDQVRVCMQDIVEAIKSVPKGITQQMLDGYEKWSKQFMKHQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMF0</accession>
    <name>A0A1B7YMF0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bet V I allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_01804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161595.1">
        <property type="nucleotide sequence ID" value="XM_018296779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMF0"/>
    <dbReference type="GeneID" id="28860886"/>
    <dbReference type="KEGG" id="chig:CH63R_01804"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01804"/>
    <dbReference type="OrthoDB" id="4436220at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07821">
        <property type="entry name" value="PYR_PYL_RCAR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="177" mass="19214" checksum="F3E9BC73C2DA4710" modified="2016-11-02" version="1">MMGVITSSNATCVTITEVSELADIMENDKTVEIVKVIDVPVAEVWAIIAAFGSEKLWFPGVVQSSLEGFGIGSIRALTFDTGTVVHEKLEIADPKTHTISYLIMDGVPNTTNPRGTLQLSAVGDNQTRFSWSGQSDWTEPSFKPILAGTLEEMFTGCIDAIEKKIQVGTIQPCYLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPB2</accession>
    <name>A0A1B7YPB2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH63R_02575</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162366.1">
        <property type="nucleotide sequence ID" value="XM_018297550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPB2"/>
    <dbReference type="GeneID" id="28861657"/>
    <dbReference type="KEGG" id="chig:CH63R_02575"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02575"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="212"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="359"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OBR13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="666" mass="74722" checksum="CD9810932401B439" modified="2016-11-02" version="1">MASEERPLGVTPPISSALPTEAENHAMQTLIDELRRQNTFESPADTQKREKVLEHLARICDEFVKRVAREREKGNDALIRDARGKIFTYGSYRLGVYGPGSDIDTLVVAPKYVTRADYFEIFPDLLKEMAPPGAITDMAVVADAFVPIIKFEFSGISIDLIFSRIAMLKQLPKDFNVQDSGLLRGLDEAELRSLNGTRVTDEILSLVPEQATFKLALRAIKLWAQRRAIYANIMGFPGGVAWAMLVARVCQLYPKAASSVIVNKFFHIMRRWPWPQPVLLKQVEGGPLQVRVWNPKLYKGDQFHLMPVITPAYPSMCATYNITRSAMTVIQQELQRGCDITDAIMLGRNPWSDLFVKHTFFTQGYKYYISVITSSTDKEAHKVWSGYVESKVRVLVQGLEQHQSIALAHAFNKGYERRHRCANETEVHQVQAGNMSFLVKDGEVHDTSSVKVETEAGLNNMPVLKSGPAETTLGIKEETEPADIKQEMSSAANLKAEKEDHSVPAIDVFTTTHYIGLTLSEGAKSLDLSYQVDNFKSLCTTWEKYDPTLNCLAVQHVRSFNLPDDVFEPGEKKPQKPQKRQANANGSAQIKKRSASEVLHAWSKLTVTPEGSSRGDRNPQADRLHRKINSRRPSANRLPLRLLAEHPSGTPHPIHFCFETAQDPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YPK0</accession>
    <name>A0A1B7YPK0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentatricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_02534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162325.1">
        <property type="nucleotide sequence ID" value="XM_018297509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YPK0"/>
    <dbReference type="GeneID" id="28861616"/>
    <dbReference type="KEGG" id="chig:CH63R_02534"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02534"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="320" mass="33375" checksum="B2C138C21CE5D3F5" modified="2016-11-02" version="1">MAKVATDFERIIQEGRERKKNEALAQKIFSKDRRQSAPTKLKPGAGPSLASRVGVKKRTASLGPKALPAGNIDGDWTHDLHGTVNGGGRGRNNGGNPGAGGLASRISAPGGRTAPVGAAAARRGDRRAEQKAAKVATAIERSGGMSDVQMTFSAPTNAPTGPAVKKGLSIRGLAGPFAVMAQNFAPGTTAADIESAMTPVGGEMLSCRIIKTSPLIVAEMVFATKEGGDAVIETFNNQTADGRIIKVYPKPGGYKEPVTTNGAHPVNVRSTSNHIIDGTNGFPEEMEEDDRGLYSDRIVGSGNSSSTNRRGRGSYRAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQW8</accession>
    <name>A0A1B7YQW8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pth11-like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162948.1">
        <property type="nucleotide sequence ID" value="XM_018298132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQW8"/>
    <dbReference type="GeneID" id="28862239"/>
    <dbReference type="KEGG" id="chig:CH63R_03157"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03157"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR14431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="400" mass="42907" checksum="E06780EED1217EF4" modified="2016-11-02" version="1">MEPNADIVQIFGPPPDGLDISESSVVQNNAAVIVLAVLASLAVVLRLMARYLQGHNLKADDWAIIASLILVGATVGLSIAGGAQGAGNHVWSFTPLGLTRVFKILYAYTFVYGSACAATKISILLFYQRIFVSNIPSFKISLILGYFLSITYPIVIWATMGNACKPLPFYWNQFVGEQGTCLDLNTFYLALGIINMINDIIVLVIPIPQVLKLQMSGRRKLAVCSIMLLGSFVCVASAVRIWYLERFSKAQDVTWMMGPVFIWSAIEPSVAIVSACLAHLAPLRKIVRNKISSTQRSAQSGPSSNSAPWRSGKAAGNSSSQKGSGALFTYGGSRFNFGGGDGMLKLKGSDDEIGLTNRITGGRSGDGKTTTADSGSEDNVNGQSIVIQSSFVQESVRNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTC7</accession>
    <name>A0A1B7YTC7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_00471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163808.1">
        <property type="nucleotide sequence ID" value="XM_018295446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTC7"/>
    <dbReference type="GeneID" id="28859553"/>
    <dbReference type="KEGG" id="chig:CH63R_00471"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00471"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="291"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="391" mass="42542" checksum="F522F5E1A03813FC" modified="2016-11-02" version="1">MSFLFPRTDTLKGCFSSPVSATEDAGVLLRCQQQQQRPSRYQARPELYGALSTVDDVKGKAKQLSAEATAEFDKASAKAQSAAGGKIELYSGKYYAACTVGGLLACGLTHTAVTPLDLVKVRRQVDSKLYTGNFQAWGKIFRSEGLRGIMTGWGPTFWGYSAQGACKYGFYEYFKRQYSVLAGPENAEKYKTLLFLSASASAEFLADIALCPFEAVKVRMQGGIPSPYKGTLDGFSKVTAKEGVAGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYHRLPGQKSDYSKAAQTGVSFVGGYLAGILCAIVSHPADVMVSKLNANRQQGEAFGAAVGRIYKDIGFGGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGFPTTGGAAPPAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YTF5</accession>
    <name>A0A1B7YTF5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_00358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163695.1">
        <property type="nucleotide sequence ID" value="XM_018295333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YTF5"/>
    <dbReference type="SMR" id="A0A1B7YTF5"/>
    <dbReference type="GeneID" id="28859440"/>
    <dbReference type="KEGG" id="chig:CH63R_00358"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00358"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="244" mass="27672" checksum="5F998880FAA58F41" modified="2016-11-02" version="1">MRLLCFPRRIINPSRNPSSSFISYSVSVPGYPSSNLLLFPPTTLLIPLLPPSLKMANPAGNISFEDFLGLSTAVFEWADSYDSKDWDRLRKCIAPELRIDYRSFLDKIWEAMPAEEFISMISDNSVLGNPLLKTQHFIGGTRYEKVSDTEVIGHHQLRVPHQKYTDASRTEVAVKGHAHSYNKHWYRKVDGVWKFAGLAPEIRWSEYDFEAVFADGRDSFGTEETNGKTDVKVVEKELKVAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUI3</accession>
    <name>A0A1B7YUI3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quinate utilization pathway activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164226.1">
        <property type="nucleotide sequence ID" value="XM_018295864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUI3"/>
    <dbReference type="GeneID" id="28859971"/>
    <dbReference type="KEGG" id="chig:CH63R_00889"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00889"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="755" mass="84204" checksum="5608EBD68A462382" modified="2016-11-02" version="1">MRRRSSPRPPSSLSPTSTPRRTSRTPEPGSARSSIASRACDACRARRRKCRFDEGEGEGEGEASPRAAVQNRTQNQTRTQCRDCRRLGIVCSFLVPTRPRGPKRRKRLPSMSAGSDGELPPRESGANQVHRQPVEPALNNNNEPVLVLPESNHHPHPPRTSQARSPFEASPNLIHGPSPHAAAHSHLNTESPSVQVANPGYPTDELCSRRLIHVLMADYLDLVYPLVPVVHRPSFRHDLATNRDVTDPDFSALLISLCALVVGLLPSRFRDYRAVDPEAGRRFGTTRTAMIDRCAEICMRQRTARYWDRINHRKWAVCYVLSVACFQTGQVNRSRMFDVEYLQLSRLLGLHRISEYEGLNCIETQLRKKAFWMLFYGYAVQTGRGVELSYFGPGELREVNYDALMPLAIDDEHILRDRILDPARPSRTTTTTTTVAAVPHDTPPTTHAPKPRCRRRRAGPAFVLADGFNIHSSVFLKGLREEMRTVGCDCELRQSPAFRLARLRELLLEMRYMLDNAPGPLRQWASSESYDDDGGGGNDEDDDDNDDNDDDDDDDDNGAAAAAAAAVAGTPDGRWAAVSSYGSPAGHSRGQAADGAPDPSEVMRGQAEVMRANIHVTHLWLQSLLLEKVEVVIQESALGNPSSGVGAAAAAEEVSEALRENWAEREDICRQMLHLLHSIPYVYLEPNGLYLTYKVRDVAVTLLNCPFQPHERPARRAVEYMRDFTRALSRLDRSETVNTNSLKSWVDVDREPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVQ0</accession>
    <name>A0A1B7YVQ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164636.1">
        <property type="nucleotide sequence ID" value="XM_018296274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVQ0"/>
    <dbReference type="GeneID" id="28860381"/>
    <dbReference type="KEGG" id="chig:CH63R_01299"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01299"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="126"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="616" mass="67422" checksum="FB22E689A36AE9F3" modified="2016-11-02" version="1">MTGAPNPEKGSPAAAKTATATSSGSSQDSPPLRPLKGVESRHSHRSRSRATSHSSTDTDPLEPLEHALTPDLEIEAEHVAREPITYMRTGTSIGSTASRPPDFEIVFEPDDPENPKNWPLWYRGWTIFVVSLSTWIIVLYSTSYTASIPGLIEEYHSTQVIATLGVTTYLLGLAAGSLIVAPMSELYGRQYVYLGCFTVSSLLIIPCALAKSLTTLIVVRFFGALFGAALIANSPGTVVDISDEEYRALAMSFYSIAPLNGPVTGPLIGGFVFQYMGWRWTNWIVLILAGVGIALMFTLRETYAPTILQRKAARMRKETDDPRWWCRYDEKVSKFHLIKLNLSRPFVLSFTEPILISLIYGILYLCFVAYPIVFSQYRGWGPGVSGLAFVGIGIGTILAICCEPIFRRIINAHPKDPVTGRVPPEATARVMTIGAVLTPIGQLVFSWTCLPATIHWAIPIAFGIPFGAGNTISFIYGSNYLAGSYGIYAASALAGNAVMRSMFGGTLPLAGPSMYRALTPQWAGTLCGLLELALIPIPLIFWRYGERIRARSPVIRQMREDQEKNDSKRAKQQARLERRREREAAAAETGAGAGEKSGGVLMNEELARPRDIEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW45</accession>
    <name>A0A1B7YW45_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_01440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164777.1">
        <property type="nucleotide sequence ID" value="XM_018296415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW45"/>
    <dbReference type="GeneID" id="28860522"/>
    <dbReference type="KEGG" id="chig:CH63R_01440"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01440"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601958" evidence="2">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="43"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="414" mass="43217" checksum="CE2FAF7E827E87D7" modified="2016-11-02" version="1">MMRYATLALATAGLASAQTFSLCNPVKGDACPANPAFGGEASYDFRTSKNIDDLESFFIVDGGVKYNTKVMSFSPDTGAEMTIFEESNAPTLTSKNYLFFGKVEVELQAAPGRGIVTSIVLQSDALDEIDWEFVGADQTHVQTNFYALGINDYTRARYYEVPFNPMTSFHTYTIEWTKESIVFSIDGKVYRTATPAEGNYPQTPMQLKLGTWVGGKGTAQGTIDWAGGLAEWEKAPFAGHYRSLKVWDYAGGDKAGAKQYEYNKGSDGTWQSINVVGAGDKASIGGVGSSNGAKDGKPIGDDKAAQSDLPVFSKISTSAPASTTAAPISSVVANTTIITSTTRANNATSSALTRPGSSASSPSGSANAQTTLPTTTGGAPAQSSTPAAAAAAAPALQASLFVGGLAAFFAAMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW78</accession>
    <name>A0A1B7YW78_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_01479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164816.1">
        <property type="nucleotide sequence ID" value="XM_018296454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW78"/>
    <dbReference type="GeneID" id="28860561"/>
    <dbReference type="KEGG" id="chig:CH63R_01479"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01479"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447794" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="35"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR16299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="526" mass="56535" checksum="FC73F69D3C2FEFB3" modified="2016-11-02" version="1">MRSITLISPLACWALIGGLAAASPAGKCDSSSFLTVQTSNGPITGHPASNGSNVLEYLGIPYVRPPVGDLRFAPPERFIGNSSYEASSFGFDCPLSPSRQVNYPDMTPQAQRIIGYFASGAGTPQSEDCLTLNIWTRRKKEAQKPVIVFFYGGRFAIGNTNSPFYNGKYFAAAQDVVVVTVNYRLNIFGFPGAPGQPQNLGLRDQRAAVEWVRDNIAGFGGDPTKITIAGQSSGGVAVDYWAYAYTEDPIVNGLIAPSGNAFSFPLNSPGVPERNWESVVAAVNCTDAADVMVCMRAQRWEAIKAAAAAVRPTSSSSVLRAIPPFYPRVDNEIVFEDYVSLTESGSFAKLPILFGNNNNEDGYYRIPAYGNGVVPTPEQVASFLLESFTCPNSYQAEARRAQGVPAWVYRYFGDWDNTRLFPTSGAYHGVDLHMVFGASEDVSGIAASEPQRRTTALVQRAWAAFAGDPVDGLSSVVGWPRFDPGEESLVLLAVDNSPEARFVKPEVYDAPCSTVTMGALATPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWB4</accession>
    <name>A0A1B7YWB4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_01516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164853.1">
        <property type="nucleotide sequence ID" value="XM_018296491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWB4"/>
    <dbReference type="GeneID" id="28860598"/>
    <dbReference type="KEGG" id="chig:CH63R_01516"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01516"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="561" mass="62112" checksum="4645B8A9F01215B2" modified="2016-11-02" version="1">MSLGEIARSLRLPDSDVAESNVWINDDIRPMPPSRRRWTTSTFISFWLTNQVAISNWQLGASLVAVGLSVWQSVIAIIIGKIIIALVAIANGMVGAEWHIGFPVVSRYIWGVYGQYFILIQRIFLSLVWFAVQSWTGGLTVVNCLSAIFPSFEYLGNVFPESSHLTTKNFIGWIIFNILLIPILYIRPERIQKLLLAFNIVSSVTLLSIMIWALATAGEPGSLLRQGSKPMSSSDLGWQIVHGITTVIGSIAVGLTNQPDYCRFARRPGDQIFGQWFSIIFFGAVFPTFGCLAASATGVIYGQPIWNPPLIVQAWLDTDYNAKSRAGAFFVGLGLLCIQLSINSIDNAFSAGMDLAGLFCRYVNIRRGAYVGLVLSIALCPWELLSSASVFISVLSAYSVFLGPVIGIQICDYFVIRRRRIKLSDLYHPRPDGSFYYWRGFNPRAFVSWVCGFATQLPGFAASVTPDSVKVGAAWINLYYLAFPLGFAISFLLHLGLNTVWPPQDAGTVDEVDYYATFTNTEARKLGVLPLASEIIESSQKGVGMRTAEKGPRTWLRSLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWZ6</accession>
    <name>H1UWZ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_04882</name>
        <name evidence="12" type="ORF">CH63R_11143</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000443">
        <property type="protein sequence ID" value="CCF32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152958.1">
        <property type="nucleotide sequence ID" value="XM_018306117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWZ6"/>
    <dbReference type="GeneID" id="28870224"/>
    <dbReference type="KEGG" id="chig:CH63R_11143"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11143"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR04440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="553" mass="61156" checksum="5AAFF9F8C0E9BFAD" modified="2012-03-21" version="1">MGKLNYFGLRGKSLNWAISVIAGCDFLLFGYDQGVTGGILTLPAFQSQFPTIDPEPKGISVGLTTSQRSTNQGIAVASYNLGCFLGAIIAIFIGNPLGRKRMIILGTAIMVIGAALQASAFSIEHLIIGRIITGLGNGGNTSTVPTWQSETCSSHKRGKLVMIEGALISGGIMISYWIDLGMSFAPGSVSWRFPLALQILFCVFILAFVWNLPESPRWLILKGRDQEAKEVIAAIADLPEDDDYCKNEYVVMKKTVEEMSKGSFKDLFTMDKNRNFHRTCIAYVNQMFQQICGINLITYYAAVIYSGLGMSRFMSHLLAALNGTEYFIASWPAVFLVERVGRRKLMLFGAVGQALTMAILAGVNSQSTYACQITGIVFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPANALSTSANWIFNFMVVMITPVAFDTIKHHTYTIFAIINAIIVPVTYFFFPETAYRSLEEMDSIFAKAAPGVKGAFDVVDVARKEPHRYGKNGELLIHYEDDKENGHATTRENRREGSTSSSEPNGLWARQDEETQNVEKSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1UXC2</accession>
    <name>H1UXC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_04968</name>
        <name evidence="10" type="ORF">CH63R_01962</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000483">
        <property type="protein sequence ID" value="CCF32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161753.1">
        <property type="nucleotide sequence ID" value="XM_018296937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UXC2"/>
    <dbReference type="STRING" id="759273.H1UXC2"/>
    <dbReference type="GeneID" id="28861044"/>
    <dbReference type="KEGG" id="chig:CH63R_01962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01962"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_3_1_1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="364" mass="40273" checksum="9CC166C59F6F3F2F" modified="2012-03-21" version="1">MDSKPVPDMDFRALPKIELHAHLTGSISRRTLHDIWVRKKQAGETDLADPLVEMPDGKHDYNLTTFFPLFSSYIYNLITDPETLRVATLSVLQDFHADGVTYLELRTTPRSLPSPTPQPPSVYVSTILSAIAAFEAAHPAGQETMMRTRLILSVDRRHTSAQARETVLLATQFRERGVVGVDLCGDPAARVHGVPGQDDVSIFRDAFAEASDLGLGVTVHFGEAECSGTPGELAEILSWGPQRLGHVIHLVEDVKREIVERRIGLELCLSCNVHAGMISGGFEAHHFGEWWGMEESMISLGTDDVGVFGSPLSNEYRLVAEHFGLCRDDVCALARRGIDSIFGGEDEKHRLRRVMWKPALAEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYI8</accession>
    <name>H1UYI8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-alpha-(Or 20-beta)-hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_05311</name>
        <name evidence="2" type="ORF">CH63R_04658</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000619">
        <property type="protein sequence ID" value="CCF33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018299633.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04658"/>
    <dbReference type="HOGENOM" id="CLU_1959424_0_0_1"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12362.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="128" mass="13587" checksum="56FEFE5A7D73866F" modified="2012-03-21" version="1">MASQSPFQGNAIAVRGDTGLALSRYPVVRGATVSIYATSADNLAAAIAGIEKDMPKARDRIMSNVVDIGKFETVKAWIDTTVERFGKLNGAVNVAGYSPPLSFLSHTSTTFGIGSPFQSHSKEKNLPK</sequence>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
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        <property type="protein sequence ID" value="CCF33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR05533.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="576" mass="62919" checksum="B54FB61A59D1A1A4" modified="2012-03-21" version="1">MGSIPQDITYDFVICGGGTSGCVVAGRLAEIPGVSVLLIEAGEHNENLENVHMTGGWSQLFDKETDWNVISEKKPAVNDRQVKLSRGKFLGGCSGCNGTLCIRGSKQDYDDWGVEGWSGEEFFKYIRKAENFHGKSWFKASNDHGTDGHLNIEPHDLAPISNLIMDSMVSKGLPLDHDMFSHGNNPHGCGHAPRTVHKGLRSTAADFVTKENKRDNLHLLVETHVEKVLMENVDGQLRATGVRAVKADGSVVEIKARKEVIVSGGAYCSPNILNRSGLGAKSELEAFGIPTLVDLPGVGKNLMDHLIVFMFYETEKAGLTNDHHVYHGDNFAKTYALWKDQQAGFLSSFPFGAFAYARLDERLADSELWKSAPRAPGRDPMGLSPKQPNIEFFTTECYGGPKQFDQFPTDGKHAFSMIAELFGPRSRGTVSLRNTDAKAVPVVDANYLADPLDVEVLAEACRFGNEIIMEGNGTKGIVKGSWPSDLVHHKYTTREEWIPYVRDNATTCYHAAGTCAMGNASDPNTVVDPTLTVKGVKGLRVADCSIMPILHGGHTQMPAYGIGEKAADLIKEAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZV5</accession>
    <name>H1UZV5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_05688</name>
        <name evidence="19" type="ORF">CH63R_11398</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000788">
        <property type="protein sequence ID" value="CCF33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018306372.1"/>
    </dbReference>
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    <dbReference type="STRING" id="759273.H1UZV5"/>
    <dbReference type="GeneID" id="28870479"/>
    <dbReference type="KEGG" id="chig:CH63R_11398"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11398"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008092_0_0_1"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CUE"/>
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    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
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    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
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            <end position="107"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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    <feature type="compositionally biased region" description="Gly residues" evidence="16">
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    <feature type="compositionally biased region" description="Pro residues" evidence="16">
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR04695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="973" mass="100835" checksum="7B06247144A7D700" modified="2012-03-21" version="1">MSEVQTRPAASRGRGSGRGGRGGFASRGGRTSGRPNGDKFDSKIDADDATAFEDQGELGELKKQYGSKAPLIKELFPDWSEQDILYALQETDGDENLAVTRIAEGTISQWGEVTKKAPRSKAKDSTTAASNIDSSSARPTRGGRSNVADAGRGRGRNTERGGRGGRGRPSNTAAPNGTRHTKDNAQPLSVPTEESNAWDTPKLDFKDAPAEDPWAPKETTEKPAAPAAAPAAAATEASKSAAPAPKTWASMLRQVAVPKPAAPKPPKQEPAPKPAEPIEPLPPVAPAAEPTPEPETEPEAQPEPATELPAEPVHEEPAPAEVPTVIEPEVVLPPSKDQLTETNLEQVVDESHPPATATVASTAADSWDPRHNAASATATPLSASQQQHQPIRPAVPTSNSGFAASAIKATTERGSRTPSYQRRVLDQEEAVRMPGNREVDRAAVQFGAFSLNEDDDIDGDREEPETRTQPPADSPVAHPRTSLPPAPQQAPVPEAIGTQKPAPGLPPPAAAAAATPTGTNASTSNVTDFANAPFSGSAGGAIPQAPASQVPQSAAAPAQPYSRFGQTGPQEPSSFPQKSIDPFTQQPNQPSASQNQFDSFPNQPSQQNQQPGGAFSSAPSEYSSYYTADQQNRPPYNYYNQPYGQQGAQAHQDSLSSQQRSFGGYNASQADNLSQYPQSGGLQNQSRYGGVTNDAQNSGHTTPNPTAQSQQAASQASQPQSHGQQSYPYNNHPYYNNAYYSNYMNYGHYGQGGYGGGPYGKGGVYGHPYGMSPQGPYDHASSPAAGFAQSSLHRADSGLSSGLGGDFGRAGSAQPGNQPGLAGSGFGGVQDTYGRGSSSFQSPAGQGFNSAAQPNNTGSANDDLKPFGDSKPGAGPSPSLGGARPGSATNTASGQTGLPPPQSGSQMSGYGGYPSHLQGHGLHGSSGYGMGGATSGQHGSAPFGSYGQQGAYGSGYYGSGNQQQRGGWGGNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0J0</accession>
    <name>H1V0J0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylitaconate delta2-delta3-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05874</name>
        <name evidence="4" type="ORF">CH63R_02286</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02000878">
        <property type="protein sequence ID" value="CCF33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162077.1">
        <property type="nucleotide sequence ID" value="XM_018297261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V0J0"/>
    <dbReference type="STRING" id="759273.H1V0J0"/>
    <dbReference type="GeneID" id="28861368"/>
    <dbReference type="KEGG" id="chig:CH63R_02286"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02286"/>
    <dbReference type="eggNOG" id="ENOG502RXKW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026443_0_0_1"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="395" mass="41565" checksum="F07A386E49D578DE" modified="2012-03-21" version="1">MTLQTYRGTLRRICGLRHPIGLSSLSRGYSSRSFPALFVRGGTSNGLVIHRRDLPPETEWHKVLPAAMGSPDPYGRQLNGIGSGVSSTSKIVVLSPPSRPGVDVDYTFVQVGIKDGSLDTAGNCGNMSSAVGPMALDEGLVTDPHIEQVDGQKFAAVRIFNTNTSKVILSRFKVGGSPPKYAPDGDYTMDGVPGTNSPITLSFLDPAGAKTGRALPTGNACDWLLLPDASTVQASLVDVSNPGVFVLARDIGLSSPEDLTPEAVEADAALKAKLDGIRRAGASLMGLNPDVESVPKIVLLFEDTRSPDVDIRCLALSMGQAHKAVPLTLALCLGAASQLPGTIPAQLLGNRSKKTIVIGHPSGRVDIGTTFEGGKIKSADLHRTARVLMRGDVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1V0R1</accession>
    <name>H1V0R1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_00159</name>
        <name evidence="14" type="ORF">CH63R_06959</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">IMI 349063</strain>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <end position="484"/>
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        <name evidence="4" type="ORF">CH63R_13935</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="chig:CH63R_13935"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13935"/>
    <dbReference type="eggNOG" id="ENOG502STPT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105480_0_0_1"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR02709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="203" mass="23717" checksum="E03B85C5559FFEA9" modified="2012-03-21" version="1">MEPVRARKRPTPGPMTESRVRPAESEASDDNRKRIDFTDLPAEIHLLISKQLIYPDALSLKHTSSYFYYLVDTGVRLKVEWLMERRMLHLECPNDRRCDLGSDLRFCRGSVPLLMQRRREHIECESRPGLGCLVYGTSMCSHRRKISARCQRWLRRRLTVELWWVLIALIPVALCWLWMGEVIMMVSKSVGESTKASTGWLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1V7F3</accession>
    <name>H1V7F3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_01445</name>
        <name evidence="16" type="ORF">CH63R_00415</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001857">
        <property type="protein sequence ID" value="CCF36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163752.1">
        <property type="nucleotide sequence ID" value="XM_018295390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V7F3"/>
    <dbReference type="STRING" id="759273.H1V7F3"/>
    <dbReference type="GeneID" id="28859497"/>
    <dbReference type="KEGG" id="chig:CH63R_00415"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00415"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_1_0_1"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000011">
        <property type="entry name" value="Peroxisome biogenesis protein peroxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="543"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="875"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1070"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR15235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1214" mass="130580" checksum="95A5E5BF76A0E1B5" modified="2012-03-21" version="1">MASRRNAQSTPAEISLAHLKNCFVNLPASLVSLLVNVNTPIQNVVVELSYRPSASASGASQQRSIFVGWTGMPSKRKAAPIVGRDGINGGRGGTSSRDQEVAQVEIDATLANTLGLTDGQRVTASIHVDPPVAHTINIEPLTPEDWEMIELHANFLEINLVHQVRALPNPAFTSGSGSLVPPHALTLHLSPTSTANVKVISLGPTPAADVAFVKISPDAEIIVAPKVRAKTSHSLGENRSVASTSKSKRSGASTVRRRSAREERKPALCLRGVDRSACADWFDEDLTTQDFSVWVDRDILYTKDFRGVNYVSVNILRPTRQASSTQKPQQDAEQSASTSKVTTKVVANLRAWDDPPDGKTIALSPALSSTLGFAGSVGGIVKIEPAPQQWPLDAVQKLIIQPFAASKKSSEGLKFGGESKAGKEEASKQFKHLYGDRKGSSSLLSGPLTDGSVIGLFEGLEAPQGWEGGIIKFEPPAINSDPLRSSTRWVLGLSEKIPIDIRDPVPRPSWMNDDGIAELQPSYEGQLVGIDKLLQDLRSHLSHLSSTLLTGALGSGKTAVARSLAHELGKDLLFHTTYFPCRKLVNDETRIATIKDTLNQVFMSASWGARLGGKALVVLDDLDKLCPVETELQVGNDNGRSHQISEIVGSTIRQYCNVETGVVVLATAEGKDSLNNVIIGGHVVREIVDLKAPNKDARRKVMESIVKQDSITAEDLLRAPQNGSRPTTADGSTAGEDSAWMDAGSQGSRENRNGAIGGFMLDADLDFLDIAGLTDGYMPGDISLLVARARNEAIIRSVNDSPSESEGGAVHLSRVDFDNALKGFTPASLRNVSLQHSTTTFSSIGGLQETRKVLLETLQYPTKYAPIFEQCPLRLRSGLLLYGYPGCGKTLLASAVAGECGLNFISVKGPEILNKYIGASEKSVRDLFERASAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQMDGAEGLSGVYVLAATSRPDLIDPALLRPGRLDKSLLCDMPMLEDRVDILKSLSSKVKLSEELTESDGAWADIARKTEGFSGADLQALVSNSQLEAIHDVLGDADPTPTTNGKVNGKSSPSQGSVPSFVQFRYGQDTAPSTKPLSRQAELAENAAIFAKLESIRLARKRVKHSQRPEGDAKLANDKEVVVKLEHLMKALESTRSSISTQERARLQRIYREFVVGRSGEMKDGQGSMEIGGRSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1V922</accession>
    <name>H1V922_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_08224</name>
        <name evidence="5" type="ORF">CH63R_04972</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002117">
        <property type="protein sequence ID" value="CCF36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161193.1">
        <property type="nucleotide sequence ID" value="XM_018299947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V922"/>
    <dbReference type="STRING" id="759273.H1V922"/>
    <dbReference type="GeneID" id="28864054"/>
    <dbReference type="KEGG" id="chig:CH63R_04972"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04972"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_1_1"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="422" mass="47431" checksum="1BAEB32D9CC67650" modified="2012-03-21" version="1">MPLDFFGHVLETGLPIWVTDNWWFITKTVVTVTVLFLIKLWSAGSSNPAERDMHGRVVMITGGTSGVGAATVLELGGRGAQIILLTHTPVSDPFLVEYIGDVRARTGNELIYAEQVDLASLHSIRKFATKWIDNSPPRRLDMVILCAATVTPAAAKRTQTSEGIEEMWMVNYLSNFHLLSILSPAIKAQPWDRDVRIIFATCSSYIGSGSLKEPLTKEDWSAGKAYKRSKLALMVFGHAFQKHLDAYKRPDDLPMNSRVFFADPGFARTPGMRRWLSRGTLWGLFAYLLTYPLPWLLLKSSEQGAQSILYAVMEPSLVRVGGGKLIKECQVVDFARKDIEDEEVAKKLWEESDKLIETTEKREATLRAMRKEEDEKLKKTEKETAAMVDDRKENRAKSSEKSSEKTNAPQKSKGKKKSKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1V9T4</accession>
    <name>H1V9T4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_08419</name>
        <name evidence="11" type="ORF">CH63R_06956</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
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        <property type="protein sequence ID" value="CCF36987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018156709.1">
        <property type="nucleotide sequence ID" value="XM_018301931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V9T4"/>
    <dbReference type="STRING" id="759273.H1V9T4"/>
    <dbReference type="GeneID" id="28866038"/>
    <dbReference type="KEGG" id="chig:CH63R_06956"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06956"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_0_1_1"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="8">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="9">
        <location>
            <begin position="122"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF36987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="483" mass="53454" checksum="8894750C94FA98EF" modified="2012-03-21" version="1">MAPSNDTITVESLPELLRDDNKVKLAGIDVDGMLRGKLVSKSKFLSVAKSGFGFCSVIFGWDMHDMTYIKELKISNADNGYHDLIAVPDLSSFRRIPWENNVPFFLVSFHDPDTQEPICACPRGLLKTALEKLQAKGYGAMAGAEYEFYQFKAPARSAESTSSTAGYLQENPPQALPSLTEGMFGYSLTRTVHNNDYFYDIFETCSKFKCDIEGWHTESGPGVFEAALEFGEIQQMADRASLFKYVVKSVATKYGITPCFMAKPKQGLPGNSGHMHVSIVDKEGKNLFARETKDENPPYPDVAGLSDLGRHFLAGLLEGLPDVMPLLAPTVNSYKRLVENFWAPVTVSWGLEHRAASIRLIAPPTAKPGATRFEVRVPGADTNPSFVLAAILALGWRGVEKKLEIPVPPLGKGQDVGGSGDKGIRLAKSLREANDRFTRKESIAREVFGDDFVDHFGGTRDHEIRLWDEAVTDWEVKRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAZ3</accession>
    <name>H1VAZ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_08742</name>
        <name evidence="3" type="ORF">CH63R_12668</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002447">
        <property type="protein sequence ID" value="CCF37396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152059.1">
        <property type="nucleotide sequence ID" value="XM_018307642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAZ3"/>
    <dbReference type="GeneID" id="28871749"/>
    <dbReference type="KEGG" id="chig:CH63R_12668"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12668"/>
    <dbReference type="eggNOG" id="ENOG502T4PF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2739898_0_0_1"/>
    <dbReference type="OrthoDB" id="4791085at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497630" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF37396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR03541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="64" mass="6933" checksum="E69C6325F66D365A" modified="2012-03-21" version="1">MQFSTMIVALFAGVALAAPSTIEARQSTICNECRKECFFSPGPDAVFKKCLDRCNTDIGCNLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VD30</accession>
    <name>H1VD30_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">TRI11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_01845</name>
        <name evidence="10" type="ORF">CH63R_03245</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <strain evidence="11">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">IMI 349063</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
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        <property type="protein sequence ID" value="CCF38603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="303" mass="33822" checksum="946224E4063D4311" modified="2012-03-21" version="1">MPSDSLKSDTAIHYPFLSFQDNTNQPSYDITYDLPSTKCLGTFRTMATASHSPTENRPLNPNVVFPPASLKSRVCSDSSRDGSGSPRAFARLTFSFVRALRAVAIAFAISLVVVNCTTQNPYYRVSALFIFFFVAQLIWLVLALLTQGNRRRRDHGTCFTVDFGFVECIFRRRGRDSDDDGHERDGVLSWLVDDGGKQRKIKSLVYTAVDTIFAIITFTLGVVATSNHGLWYSEHHVPVAVLGIFVGVFEGAIAISQQFAILKSAKIQIMWDEDEETDLGSHKYRIRLPQSPEQRHAAMSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VEY3</accession>
    <name>H1VEY3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_09791</name>
        <name evidence="6" type="ORF">CH63R_01656</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003156">
        <property type="protein sequence ID" value="CCF38786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164993.1">
        <property type="nucleotide sequence ID" value="XM_018296631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VEY3"/>
    <dbReference type="STRING" id="759273.H1VEY3"/>
    <dbReference type="GeneID" id="28860738"/>
    <dbReference type="KEGG" id="chig:CH63R_01656"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01656"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="451"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF38786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR16476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="562" mass="61552" checksum="8E04F22A50DE6220" modified="2012-03-21" version="1">MKIYTSRPIEVPRDLNLTQLLHTSATELPESHIIAADSLTNRSITLGELRDRAGRIAKGLKDVLSPPDQARWAVALPNSVEFLEIFHAILWTGGIVCPVNHALKVSEIGHGLAISRPHFVVAYGPMVTSIREAVGVAREELHEKGVAWQSPPILSMVKPCRGTRSIPDDFLSSTRLPIPRWTDTSLRLASIHLSSGTTGKPKGVELTHHNFVSNVMQLVALDRARQMFNPSSRTVAFTPWAHIAMTTAPLFLGPYTGMFHHAMPRYNIEDFGRLVESTQATTFQGVPSVVLSLANSDITERFDFSRAQIITIGGAPLKAEQLSRLLGRAPWRLVQAYGMTEAAGYVAYQEFGEVVPDGCTGKLLPGIEAALKREGTTEDAPPGGPGELWLRGPNITRGYAFDPDANRAAFPVEGWYNTGDVCRIDECGRVSIVGRTKELIKYKGFQVSPGELEQIVNSHPHVGEAGVGALWDADQLTEVPTAWVVLKNGGNETRREEVVDKLRVIQRAVDGQVSGYKKLRGGVWVVDKVPRNATGKIIRPELVKMTQGPCSLEKPRTLTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VF72</accession>
    <name>H1VF72_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_02005</name>
        <name evidence="16" type="ORF">CH63R_00653</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CACQ02003201">
        <property type="protein sequence ID" value="CCF38875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163990.1">
        <property type="nucleotide sequence ID" value="XM_018295628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VF72"/>
    <dbReference type="STRING" id="759273.H1VF72"/>
    <dbReference type="GeneID" id="28859735"/>
    <dbReference type="KEGG" id="chig:CH63R_00653"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00653"/>
    <dbReference type="eggNOG" id="KOG0833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_2_2_1"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="69"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCF38875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OBR15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="171" mass="18646" checksum="121D49591F21B0B3" modified="2012-03-21" version="1">MVFTPEILDIVNESQTADTARKFELTIAEVNELHQRATAAKATAYCPYSQFRVGSTLLSNDGQYTAGANVENASYPVGTCAERVAFGKAITEGIRGFKAVAVATDIEAPCSPCGMCRQFIREFVDLETPILMFNKDGKYVVMRLEELLPLSFGPEYLPPPDVLQKSRAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>H1VFN0</accession>
    <name>H1VFN0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH063_09980</name>
        <name evidence="5" type="ORF">CH63R_06722</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02003278">
        <property type="protein sequence ID" value="CCF39033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159547.1">
        <property type="nucleotide sequence ID" value="XM_018301697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VFN0"/>
    <dbReference type="STRING" id="759273.H1VFN0"/>
    <dbReference type="GeneID" id="28865804"/>
    <dbReference type="KEGG" id="chig:CH63R_06722"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06722"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCF39033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="375" mass="41422" checksum="965FE209810933E4" modified="2012-03-21" version="1">MEIEIPAVHPAVAVKAPREPLIIIDAPTYPPEAGEVIVRVEWTSSTPYHLHQADGGLLIDMFPRILGDTFAGTVLLVGPGPHHVHLQVGDKVLGYSFRDDKDGKEKAAQTLITVPTFLLGKMPRGLTMQEAVTVPDNIVTVFQAAVVDLGLPLPWPVPEGWTPPEADAPILLWGGAGSVGMYAIEVFRHWGYRNLVVVASPRHHEYLRSLGATVCFDYRDARVVQRIREYLGPGGVPYVIDCIGHLTGSLKPITQLAERGTKVAVMLPVVIKDPTEIEAPVYQMTEPAEGQWKEGVVVKGVRTHFYLKNKLFKDKMQCEIIPALLEQKVVRPNPQRIVEGDTLLERAQDSIVLLRNKAVSGERLVWRVSEDSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJ72</accession>
    <name>H1VJ72_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">CH063_02311</name>
        <name evidence="13" type="ORF">CH63R_05749</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="CACQ02003979">
        <property type="protein sequence ID" value="CCF40275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158574.1">
        <property type="nucleotide sequence ID" value="XM_018300724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJ72"/>
    <dbReference type="STRING" id="759273.H1VJ72"/>
    <dbReference type="GeneID" id="28864831"/>
    <dbReference type="KEGG" id="chig:CH63R_05749"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05749"/>
    <dbReference type="eggNOG" id="KOG2994">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032162_2_0_1"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="125"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF40275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="39248" checksum="AC3A7F207FA63231" modified="2012-03-21" version="1">MSTLKRKAGTLSAADNKKPKQDGSIMSFFGAPKPVAKAGGAAAPPLEAASPAIKFDKAKWVAGLTAEQKELLQLEIDTLHESWLALLKDEVTSKEFLDLKRFLNRESDAGKKWFPPKEDVYSWSRHCPFNNVKVVILGQDPYHNHNQAHGLAFSVRPPTPAPPSLKNMYIALKKDYPTFAPPPNKGGLLTPWADRGVLLLNACLTVRAHEANSHANRGWERFTQKVIDLVATKRSRGVVFMAWGTPAGKRVVKVDAKKHLVLKSVHPSPLSASRGFFDCGHFKKANEWLVTRYGAGAEIDWDLSGAKKVETTVAEPKTVETDNNDEVKKVDIEKETEVKTLPKEVPEDLTEDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1VJZ8</accession>
    <name>H1VJZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Seed maturation protein pm25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_11084</name>
        <name evidence="4" type="ORF">CH63R_05423</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004148">
        <property type="protein sequence ID" value="CCF40551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158248.1">
        <property type="nucleotide sequence ID" value="XM_018300398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VJZ8"/>
    <dbReference type="STRING" id="759273.H1VJZ8"/>
    <dbReference type="GeneID" id="28864505"/>
    <dbReference type="KEGG" id="chig:CH63R_05423"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05423"/>
    <dbReference type="eggNOG" id="ENOG502STFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142972_0_0_1"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF40551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="151" mass="16184" checksum="805902E9D9910296" modified="2012-03-21" version="1">MAVNQETVQHLADNGHIISPKEISEIAQAEKAQTGNPVPTVGGLTATAQSLHDKQQNFLVKKAEIEKKPESDITKDDAKEIQSAEARLLGHRPPTGSISAHIQSIADKNEKSLPSEVGKDEAAATIEKDEAVASKVTEVSEKKEQSVQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>H1VK01</accession>
    <name>H1VK01_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TfdA family Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_11087</name>
        <name evidence="10" type="ORF">CH63R_03695</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004151">
        <property type="protein sequence ID" value="CCF40554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159916.1">
        <property type="nucleotide sequence ID" value="XM_018298670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VK01"/>
    <dbReference type="STRING" id="759273.H1VK01"/>
    <dbReference type="GeneID" id="28862777"/>
    <dbReference type="KEGG" id="chig:CH63R_03695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03695"/>
    <dbReference type="eggNOG" id="ENOG502SHEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_1_0_1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
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            <dbReference type="Pfam" id="PF02668"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OBR11399.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="395" mass="44250" checksum="5C962CAFDCBC9065" modified="2012-03-21" version="1">MSPSATEAAAAKVEDIKAKVLPAKESQPASGLSAQEEELPEVRTGHKEPLKKSGVLDQFEHFDVTPIIGREYPTVDLKELLRAPNSDDLIRDLAITISQRGVVFFRKQDNIDNDLQKELVQRLGELSGKPSTSKLHIHPVNNSARGDTKDDAISVISSAQAKKLDLHRFLNYTKKQTQKTQWHSDITFEPVPSDYALLRLTQLPKTGGDTLWASGYEVYDRISKPLQRFLDTLTATYAQPGFNAAAEKNGFKLFTEARGAPENVGELLEAVHPVVRTNPVTGWRSIFAAGHHVSRINGLSDEESRHFLDWFVQLIVENHDLQVRYRWQNENDVAIWDNRSVYHAATPDYVTEGLGERKGSRSVSLGERPYFDPQSLSRREALRAEAIVSLKSDSS</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>H1VL52_COLHI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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        <name evidence="3" type="ORF">CH63R_10848</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02004401">
        <property type="protein sequence ID" value="CCF40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR06728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_018305822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL52"/>
    <dbReference type="GeneID" id="28869929"/>
    <dbReference type="KEGG" id="chig:CH63R_10848"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10848"/>
    <dbReference type="HOGENOM" id="CLU_2739882_0_0_1"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR06728.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="71" mass="7918" checksum="089D5C3438A0295C" modified="2012-03-21" version="1">MICTTLMHPYQHRFFLLGMGRKLRMNTAPCSAVGGDGLEIVLCKTTHTSKPARSLKNNRSATMDGKTHKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>H1VL72</accession>
    <name>H1VL72_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI-anchored cell wall beta-1,3-endoglucanase EglC</fullName>
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        <name evidence="5" type="ORF">CH063_11399</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004416">
        <property type="protein sequence ID" value="CCF40975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151031.1">
        <property type="nucleotide sequence ID" value="XM_018308713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VL72"/>
    <dbReference type="STRING" id="759273.H1VL72"/>
    <dbReference type="GeneID" id="28872820"/>
    <dbReference type="KEGG" id="chig:CH63R_13739"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13739"/>
    <dbReference type="eggNOG" id="ENOG502SI3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_0_0_1"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003556124" evidence="4">
        <location>
            <begin position="19"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF40975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR02513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="355" mass="38122" checksum="72E984D44466B7E2" modified="2012-03-21" version="1">MVLLKPCFLTWLAIGAAGQQMPSGLLGFNSGATKDNNDPKDQSDFQAEFTTAQGLRGSPGAFNSVRLYTMIQAGTTNDPISAFPAALATNTSMLLGIWCSGTQTIENELAAMRSAIDRFGQRFADLVVGISVGSEDLYRLSESGIQNNAGLGQGPDIMVRFIREVRDAIEGTILSGKPVGHVDAWSAFGNESNSRVVDELDWLGTDLYPYYEADKGNDIGNATTIFDYIYNVSLNATRGKPLWVTETGYPASGPVRGQAVASVSNAAQFWQEIGCDRLFGRVNTWWYTLRDSNPANAEKFAITEDLKKTAKFNLTCAPGSGAPAAINLTSKASSLYTAQVLWVPFAVVLGVLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLZ8</accession>
    <name>H1VLZ8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S protein assembly co-chaperone HscB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_11587</name>
        <name evidence="6" type="ORF">CH63R_00522</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004582">
        <property type="protein sequence ID" value="CCF41251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163859.1">
        <property type="nucleotide sequence ID" value="XM_018295497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLZ8"/>
    <dbReference type="STRING" id="759273.H1VLZ8"/>
    <dbReference type="GeneID" id="28859604"/>
    <dbReference type="KEGG" id="chig:CH63R_00522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00522"/>
    <dbReference type="eggNOG" id="KOG3192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068529_1_0_1"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF41251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="243" mass="27260" checksum="5211E270DA67FA95" modified="2012-03-21" version="1">MARPSAMLAAANSSRAATHMRWPSGLSSSANQKRWISGTVALFRPAAPARSSETTTDSGSQESKPLMTHYEFFPITLPDGPPPKGHFPIDQRALRREFLRLQAKAHPDMHPAELKARAEATSARINEAYKTLSNPLLRAQYLLSLRGVDVANDETLKVEDPDLLMIVLEAREEIEEAASEGELEGQRAANDERIRESEEVLEEAFRHDDIETAKREAVKLRYWVNIQESLNNWEAGKPIVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VMB3</accession>
    <name>H1VMB3_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_02580</name>
        <name evidence="13" type="ORF">CH63R_12641</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004656">
        <property type="protein sequence ID" value="CCF41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152032.1">
        <property type="nucleotide sequence ID" value="XM_018307615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VMB3"/>
    <dbReference type="STRING" id="759273.H1VMB3"/>
    <dbReference type="GeneID" id="28871722"/>
    <dbReference type="KEGG" id="chig:CH63R_12641"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12641"/>
    <dbReference type="eggNOG" id="KOG4657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065188_0_0_1"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR03514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="258" mass="30399" checksum="44565DD55E7D9ADF" modified="2012-03-21" version="1">MSSAFRESSLSASLNRQSLAATPSVAETLPNANFGFEELRDRMTKFTSKFDTFIEQGRKRVLEERNQFRMNVAELQEDQRMKKKDIEILQLKTSTHQQTVAKEKAETREMQAAIAQLSEERDKHIATRDALKKQIEETQREIDARLAAQRAHTKQLEAQSRFNVPELEFWQQNLGLRIEGAGQDDRLKFVYTYVDDQDWEREAWFELNTSSRDYDIRHCRPKLERERVERVLDQLNETRELAVLLKGMRELFVEAMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>H1VND6</accession>
    <name>H1VND6_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_00406</name>
        <name evidence="12" type="ORF">CH63R_00760</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02004902">
        <property type="protein sequence ID" value="CCF41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164097.1">
        <property type="nucleotide sequence ID" value="XM_018295735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VND6"/>
    <dbReference type="STRING" id="759273.H1VND6"/>
    <dbReference type="GeneID" id="28859842"/>
    <dbReference type="KEGG" id="chig:CH63R_00760"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00760"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010895400" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR15580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="494" mass="55263" checksum="29795D5FEA4019FF" modified="2012-03-21" version="1">MRAFAIAAGLLSLLSPVIASSDSSAADKVSEVNLPTNFKPPQVFKNVNLVHIVSLEKNYVKESINVLIENIDKQPQDEYYLPFTPNQMSRIGGFETKDRKNPETGLFAVDAVEIEPLSETQYFKIRLPTPLKAGGQQTLSISYYLLRAYNPLPASIAQDEQQYLAYDFSVYAPSAYVTSKQKTEVKSHSSNIPDYTRFPGSGDIKEFPQKQGAKLVYGPFDEKPAGAVAAAQVRFEFTKPVTHVARLDRDIEVSHWGGNVAFEERYELYHRGANLSKLFNRVKWAQAQYYNPNTYALKELKFPLKVGSADPYFVDVIGNVSTSKFRSNKREALLEIKPRYPIFGGWKYPFTIGWNSDAKNFVRTVEAGKYVINVPFLEGPKQPEGVEYGQVNLQILLPEGATNVKFYTSLPQSAITDTAIGVHKTYLDTVGRTSVTIKANNLVDEFRDREVIVSYEYSVVSALRKPIVIFSSTVVLFVAAWLVGGLNPKISSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VP96</accession>
    <name>H1VP96_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_02744</name>
        <name evidence="2" type="ORF">CH63R_03232</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005112">
        <property type="protein sequence ID" value="CCF42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163023.1">
        <property type="nucleotide sequence ID" value="XM_018298207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VP96"/>
    <dbReference type="STRING" id="759273.H1VP96"/>
    <dbReference type="GeneID" id="28862314"/>
    <dbReference type="KEGG" id="chig:CH63R_03232"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03232"/>
    <dbReference type="eggNOG" id="ENOG502T69U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043559_0_0_1"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="479" mass="54787" checksum="424E70F2BB08D158" modified="2012-03-21" version="1">MAPPVTVFENPWAKEKPKILLQAAAARHIDIVEIFLKLLPYFKQDGQGNIHDEALTLSEWRYICYLRFLDFSGESPNDFPPPWDVAIIWYCHLLSPTRFHRHLWDGKHRAYGLNHHQFPATRLLALINSGGWSDKKAEKKWQFFNRKKLGPELPYQLWRYPPWEVRRRSSILSMLSTSKPNSQIGEEPPIVMYNLNGTLCRPLWKDRWSLSDWSEVRTGRRLETCLYVVVHRRFGEQCELTIWPDLRDLRATLDRQIAFWKAAIHARDTQKDFDTIVGESVEDYERFIKLLARPPDKPSAASNLALDMDTLYRDEERARYSGNREFVPPNLVVDLLWHTHRLYPASYWTWSFAVTRRLIDYEPSTSATAARRTLAETRLEWRKKYHEDCPEYATMDDAGMGDYIADAAVVPAGHSARVKAKWILGGLNPVKGRNRYTKGVYCVYDGIYVPFEGSACSGDGGGGGGGDGGCGGDGGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQU7</accession>
    <name>H1VQU7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI anchored serine-threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12556</name>
        <name evidence="4" type="ORF">CH63R_05285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005508">
        <property type="protein sequence ID" value="CCF42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018300260.1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05285"/>
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    <dbReference type="OrthoDB" id="5152093at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 3"/>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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        <location>
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            <end position="208"/>
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            <begin position="137"/>
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        <location>
            <begin position="137"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12989.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="208" mass="21056" checksum="CCC05B62BBA02339" modified="2012-03-21" version="1">MLKTLLISALSASALAADAFPVFNKRQTVPIPCSESGRKACGDGCIPLTYTCCPDQQGGCPLSSTCWLGTNGAYGCCPIGRRCTGPGGVDTLPGSTVTSTIFFTESVPDDETSTSFFVSTSTSTSKSVIIFTSSEESTSTQTRFVPEPTTSSPPPVATNTRTTTSAAPTARPNSTSAGTPPVTVNGANSRGGSLLQAVAAGAVALLAI</sequence>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005711">
        <property type="protein sequence ID" value="CCF42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155254.1">
        <property type="nucleotide sequence ID" value="XM_018305830.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VRM7"/>
    <dbReference type="STRING" id="759273.H1VRM7"/>
    <dbReference type="GeneID" id="28869937"/>
    <dbReference type="KEGG" id="chig:CH63R_10856"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10856"/>
    <dbReference type="eggNOG" id="ENOG502QPRK">
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    <dbReference type="HOGENOM" id="CLU_1283178_0_0_1"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Aromatic compound dioxygenase"/>
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        <property type="entry name" value="Intradiol_dOase_core"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
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            <dbReference type="EMBL" id="OBR06736.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="215" mass="24122" checksum="1FD93A0DB2C8A790" modified="2012-03-21" version="1">METQTGIPLVLELQFINTRTCRPIGDLFVEIWHANASGVYSVVANIDNRNSLSTLQGNEEGSGERTMIGRIIDESWLRGVQQTGANRVVRFKTIMPGWYLGDSGNGTLASSFPANHSVQASHVGQTFFDSNLLDHVAAIHPYKSNPQWRNKNDEDAVLTQESNTSEPMVQYMMMGNGIEEGLLGWIVIGIGPEVNVRRAASWYGTWGRMWRKMWY</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="H1VS02"/>
    <dbReference type="STRING" id="759273.H1VS02"/>
    <dbReference type="GeneID" id="28863986"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04904"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0004029">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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        <property type="entry name" value="Ald_DH_C"/>
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    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
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    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
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    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
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    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="233"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00024226"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="467" mass="50707" checksum="3A7EB83B5B6501E1" modified="2012-03-21" version="1">MSVEVLKTISPTTNEPIITRNGVSQADLDELPNTATKAFESWSKTSLADRQAIVKKALNLLLEKKDELAEELTVQMGRPIAYTGVEVATAVKRGEYLLKISDEVLKDTDGEPEKGFKRFIRKVPVGPVLVLFAWNYPYLILVNSLIPALLAGNTVILKPSPQTPTIVEHVAKVFEAAGLPAGVLQYFHCGSPIMIESIVRNPKVKLVAFTGSVAGGLAVQQAASDRVVNVGLELGGKDPAYIRDDVDIDWAAAEIVDGAVFNSGQSCCSVERVYVADKIHDAFVAAVQKVLEGYKLGDPFDKGTHVGPVISKRSKEAIESHIQDAIAKGATDATPANESFNNPPPKGNFVKPTLLTGVDHSMTVMTEETFGPVIPVQRVKSDDEAVQLMNDSEFGLTASIWTKDTDQGYALADQVEAGTVFVNRCDYPSPDLAWTGWKNSGKGQTLSRFGFDQFVKLKSYHLKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSI0</accession>
    <name>H1VSI0_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
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            <ecNumber evidence="5">1.2.1.95</ecNumber>
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        <alternativeName>
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    <gene>
        <name evidence="20" type="ORF">CH063_03016</name>
        <name evidence="21" type="ORF">CH63R_10366</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CACQ02005913">
        <property type="protein sequence ID" value="CCF43188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154764.1">
        <property type="nucleotide sequence ID" value="XM_018305340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VSI0"/>
    <dbReference type="STRING" id="759273.H1VSI0"/>
    <dbReference type="GeneID" id="28869447"/>
    <dbReference type="KEGG" id="chig:CH63R_10366"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10366"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="623"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCF43188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OBR06246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127087" checksum="AAC2C6A9E7D0045E" modified="2012-03-21" version="1">MAPELPDPTSDLHWSAFRGAIQDIFSENAKKHPDRLCIVETASSTSPRREFTYRQIDEASNLLANHLVASGVQRGDVVMSYSHRGVDLVVAVFGILKAGATFSVIDPSYPPDRQNIYLDVARPRALVVIDKATKEAGELTDKVRTFIAENLDLKTEVPALEIRADGTLVGGQVNGKDIFAGLDKENGPNVLVGPDSNPTLSFTSGSEGKPKGVLGRHYSLAYYFDWMAERFNLSDKDKFTMLSGIAHDPIQRDIFTPLFLGAQLLVPSKEDIQHEKLAEWMREHGATVTHLTPAMGNVLVSNASAEFPALHHAFFVGDILIKRDCKALQKLARNCHIVNMYGTTETQRAVSYYEVPSVAADPTFLERFPDNVIPAGTGMKDVQLIVVDRENTDRVCGVGEVGEIYVRAAGLAEGYLANEELNKTKFINNWFVKDNRWAELDQQATKNEPWREFYKGPRDRMYRSGDLGKYTEDGNVVCVGRADDQVKVRGFRIELGEVDKFLSDHSMILDNVTLVRRNKDEEKTLVSYIVPDMQRWAEWLAQNDKKEDTSGGDSLTGRLRRFWPLGEEIRKYLKTKLPIYAIPEIIIPLEKFPLNPNGKKDKPALPFPDAAQIAEARPRAEVADLSETERKVAGIWGSLLANIDERSLGHDDSFFDIGGHSILAQQMLFQVNRTWPGVNVTMAVVFRSPSLKAFSAEIDGKLSGNAPEGVNATPEGEDYFEDAKKLLTTLPEKFASFDKKAADVKTVFLTGATGFLGAYILRDLLSRNVPNVKVIAHVRAIDDVDAYNRVVKSCQAYGVWQPSWKNSLVAVQGSLGKPLLGLSQERWDSLANEVDVVIHNGAQVHWVLPYSNLKPANVQGTLDVLSLCAAGKPKQLAFVSSTSVLDHPHFVKLSQGGSLVSEEDDLSGSSKNLGNGYGSTKWVAEYLVRNAGKRGLTGTIVRPGYITGEQHSGTSNTDDFLLRMLKGCIQLNSRPKIENTINMVPVDHVARLVVASALHPPRQPLGVAQVTSHPRLTFRTYLSALEKYGYNVPEVEYSQWSKSLQDYVAEGKEHALMGLYHLATTDLPADSIAPELDDVNAAAALRSDAELTGEDLSAGGAVKDETVGRYLSYLIAIGFLEAPEKPGQLEIPAAEISPEQKEALLRVGGRGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSK5</accession>
    <name>H1VSK5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH063_12976</name>
        <name evidence="2" type="ORF">CH63R_01296</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
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                <person name="Shea T."/>
                <person name="Sisk P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005981">
        <property type="protein sequence ID" value="CCF43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VSS4"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05234"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR12938.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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    </evidence>
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        <source>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="5" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02006901">
        <property type="protein sequence ID" value="CCF44437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018309287.1"/>
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    <sequence length="317" mass="35312" checksum="026D23A80F84971F" modified="2012-03-21" version="1">MKVAIVGATGETGSSIVNGLLASADTKFDITALVRPTSLKKPEVLDLEKRGVKIAAADLGGPEDEITNQLMGIDVVISTILASELKYEIPLANAAKKAGVKRFVPCFFGPVMPARGMLWFRDHKEDTLNHVQTIYLPYTVIDVGWWYQISLPRVPSGRLDSVVGVTGNRIAGDGSTVCGRTDLRDVGNYVARIIADARTLNQKVFAYTDLRTHNEVYDLIEKLSGEKIEREYLSSEQIEAEIANKDNIDRLSVLQFQKSWDLRGDNTPEYARYLGYQVAKDLYPDFKGISFEDYCKEALEGRLKPLYERRRKATAAA</sequence>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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    <name>H1VXM8_COLHI</name>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007345">
        <property type="protein sequence ID" value="CCF44990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154105.1">
        <property type="nucleotide sequence ID" value="XM_018304681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VXM8"/>
    <dbReference type="STRING" id="759273.H1VXM8"/>
    <dbReference type="GeneID" id="28868788"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09707"/>
    <dbReference type="eggNOG" id="ENOG502SRAW">
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    <dbReference type="HOGENOM" id="CLU_090929_1_0_1"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DinB/YfiT-like"/>
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        <property type="entry name" value="DUF1993"/>
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    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="DUF1993"/>
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        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF44990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR05587.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
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    </evidence>
    <sequence length="184" mass="20458" checksum="6642652A5FBC9EE9" modified="2012-03-21" version="1">MTYTLYDASVPLLLAGLNTLLGLLTKAEAYAADKAISADDVLGWKLAEDMLPFSVQYYIATDCAVKIVARVQGTEPEALGREFKSIADLRQRVEYTIALVKAADPKTFEARTDALVPLGLGFGQGEMQIRARDYLVAYGMPNFFFHLQTAYSILRAKGIQLGKADYLGPFMNPFVEEYKKQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3Q4</accession>
    <name>H1W3Q4_COLHI</name>
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        <submittedName>
            <fullName evidence="16">Emopamil binding protein</fullName>
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    <gene>
        <name evidence="16" type="ORF">CH063_15631</name>
        <name evidence="17" type="ORF">CH63R_05161</name>
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    <organism evidence="16 18">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
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            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02009380">
        <property type="protein sequence ID" value="CCF47117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161382.1">
        <property type="nucleotide sequence ID" value="XM_018300136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3Q4"/>
    <dbReference type="STRING" id="759273.H1W3Q4"/>
    <dbReference type="GeneID" id="28864243"/>
    <dbReference type="KEGG" id="chig:CH63R_05161"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05161"/>
    <dbReference type="eggNOG" id="KOG4826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072128_0_0_1"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="65"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCF47117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OBR12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="237" mass="27191" checksum="E9560B7135D57D64" modified="2012-03-21" version="1">MAAEVVMNASIPLHPYYPSDAILPGYVANTFSAHELRAIFAAGATAILVPTYRLIKKTRPNLPNGEVATALWFTLSAFIHFFFEGYFSYNQANMPATVHIFGQLWKEYSLSDSRYLTQDSFIVCMETITAVFWGPLSFACAYCIVTAHPLRHPLQLIISLGQLYGDVLYFATCSFDKLVARIMYCRPEEFYFWCYYVFFNAFWIVIPFYLIVRSCVETKRAFEKAAELEGRSEKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQC3</accession>
    <name>A0A1B7XQC3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_14532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150478.1">
        <property type="nucleotide sequence ID" value="XM_018309506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQC3"/>
    <dbReference type="GeneID" id="28873613"/>
    <dbReference type="KEGG" id="chig:CH63R_14532"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14532"/>
    <dbReference type="OrthoDB" id="4842209at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR01960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="412" mass="44478" checksum="213ADF01D2ED7C58" modified="2016-11-02" version="1">MSLFADTAHANLLADTTSDRAILTMSTPTPTASPAPSLSPSRSPSSSLSTFHDGSGNTQMGLALDEDNTVNIGLFSAEGTGPCPTPGCPPTSLRLDTPENLEADLDALCLWQSGLLLLPPGSSPSPTAEFRLAPEHLNRFQSLLRQLRIARFSYDFPSSYARVVMVESTLHAQAIRRASELVIRARDDMVTAVSAYANGLQDAQPAADAAHLAIRLENLLDNGAAKVELPGGLLRQPDMQLIDLPGVSKLPPFVVEIAFGQTRQSAAAKAKQYLAQTDGRIRAVLILDFQYPKASSVRLGLWTAHSDAKVIDPVEVQKSTLFDADVDGDSNAPVDGTLRLFASDFLSIDPQELPQELSRPSSVGPDADSLRARRTGTDADNDHWKQIQAWGAWEVEWAYKLREPAVEDFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQS8</accession>
    <name>A0A1B7XQS8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_14414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000011">
        <property type="protein sequence ID" value="OBR02113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150631.1">
        <property type="nucleotide sequence ID" value="XM_018309388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQS8"/>
    <dbReference type="GeneID" id="28873495"/>
    <dbReference type="KEGG" id="chig:CH63R_14414"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14414"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR02113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="357" mass="40322" checksum="289FAC80AD0119B0" modified="2016-11-02" version="1">MVDGPDGLEIDGNMFLHNARDWTILHDLSRVRTRRRACQKPRRKRSGGRRRSHEGQDRAVSDSVRRGAIQNRHRPLGARRRLPHAHPRPVVQHNTPRDAYYEMGTAPLDFEVLAELATLLIQKGLDVDAKDGHGRTALHIAAKLGDSGIVKALLDEGASPALPDGAGRMAIDIAKMQSRRLKSSTWLSLPGLSPETESPSDEDEGFVPRRFIGLLRATGQAGVLTDQAGRRAFYRRVVWCPESAVRWGRRLWIATEGATTVMQLNGEGFVRRDPRLVDVDLETVAAMFWTTTGHPRIICQLKTCIQENSKLQNDIVRVQFDSTPDMARFVEFCLPRVLAREPCSQAWIRHRWTRSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRG1</accession>
    <name>A0A1B7XRG1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH63R_13584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150876.1">
        <property type="nucleotide sequence ID" value="XM_018308558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRG1"/>
    <dbReference type="GeneID" id="28872665"/>
    <dbReference type="KEGG" id="chig:CH63R_13584"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13584"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR02358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="763" mass="85281" checksum="3402EBA6B6647880" modified="2016-11-02" version="1">MSDLRDEKTALSDPKASSAPKVAVDPVFETSEKLFLGGLDSDSPDGTKRNSVDDSETEYDFKSAEFANIPELVRTVVGFEDDPSLPVITFRSLLLSTIFCIIGSTVSQLSYFRTTTAPFPVFFVILASAPLGRFLARVLPDYTVPLGRFSFSLNPGPFSIKEHAIIGIAANAGSQGQWATFLPTNAALYYGITMNPAVALFFGWGASLLGFSFAAMVRKILIDDPEFIFPLSLQQVTLYRSMQGKTELHKSVSKKQMKVFWWILLATFIWQFLPEYLFPFVAALAPLCWFASKNHTVNFLGAGRGGIGLLNITLNWSNITSTVITYPYSVQVTVFVGFVITTWILIPVAYFGNLWGSPTYNIMSNGVFQKNGSAYPFESLIYTDSSGVQHVNETAYHEVGLAYSGAQYTWEIFMWYASYISSFVWCGLFLGPKVAKIWKARKAEGEYHQDRLREWGILTAVPIGILLVIVATKSVWMPTWTYFVALGFGGAAMLPMSLVYAMSGYSIKVGFFNELIYGYMIDAPGSSRHPLGQLAYRIISGNVWYDARTVLEDQKIGHYLHLPPRQVIGIQIIANMIALPINYGVMRWVIASKFDYVSGRVPDPQGQWTGQEFKSYNTAGIQYALVGPKKLFASSFFKPVLYGFPAGAIAPIIIWLLHKKFPKARFDLWNSTIFFASAATFHGNLSTGPFTTFLVGTFFNFYLYRYRRAFWNKWAYISGAALDTGFNANLLFIFIFLGTTGAVMVKWWGNNADNIERCFALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRG4</accession>
    <name>A0A1B7XRG4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Duf803 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_13573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150865.1">
        <property type="nucleotide sequence ID" value="XM_018308547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRG4"/>
    <dbReference type="GeneID" id="28872654"/>
    <dbReference type="KEGG" id="chig:CH63R_13573"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13573"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="729" mass="79266" checksum="0EF4A1881149584C" modified="2016-11-02" version="1">MDHSAKMLTEAHEIYARMGGSTGETATRPPAYKAIGIALAVASGAFIGTSFVVKKVGLLKANEKYNEAPGEGYGYLKNAWWWTGMILMIIGEICNFVAYAFTDAILVTPLGALSVVLTAILSAIFLKERLSMVGKVSCFLCIVGSIVIVMNAPENSAVANIQQMQSYVIHPAFLSYAGVIIIGAAITAWYAGPRWGKKNMLVYISICSWVGGLSVVATQGLGAAIVAQAGGQAQFNQWFTYVLLVFVIATLLTEIIFLNKALNLFNAALVTPTYYVYFTSTTIITSAVLFRGFKGTPTAIITVVNGFLTICAGVVLLQLSKSAKDVPDTAVFSGDLNQIHTIAEQEQPETEPKADAIRGAAAIVRRLSSARQKMEEEEFRRLHEEKLRESLEPVSEDGQPMYEWDGLRRRRTMTVGSRSTRGTVLSPYPPSQSGVPRTPTVVPPTSPQAHPPLGMSHFPTEEEMAEHDRPTSPGMLSSIAGTIRERARSVLSPNQPQFQDPRVQSPMHPVPLTEIAVSTLKSDGDQSPYHGTSREHVYGLPAGGRGNLEYTGAAGIYDQRAVSRGSVFSGTSSHLAPTPPPHSARRQFSFTNMFKKHQADAPPQHEEEQPQPQLRPTSRYGLGSRGYSSPQVKNATEEERLGLVKGDSNLMPALQHYDDDDEEEDPYIDDKMRPVDSTPSPPQHSRYGRGITTPPRRGSDGRDTDFESEAPTPPPHRPQPGGGRPGAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRN5</accession>
    <name>A0A1B7XRN5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein s17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150937.1">
        <property type="nucleotide sequence ID" value="XM_018308619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRN5"/>
    <dbReference type="GeneID" id="28872726"/>
    <dbReference type="KEGG" id="chig:CH63R_13645"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13645"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF1">
        <property type="entry name" value="CIRCUMSPOROZOITE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600970" evidence="2">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="518" mass="51771" checksum="275666601FD53DF3" modified="2016-11-02" version="1">MKFQTPTVLAALVALAAAEVPQEHSHEKYLRAVNALLKQDNPNNIVDAVFGLLGNAAAADGAGDVTNLDCLHQVTADSAFSAAKAAGDVDGMASALVFRAVERNTGAVGLKSVLCDETAVNPEIAALTQHQDPASENAAEENKAITLELARQLAAVGADPQLALDSGTFAPGDVNDATGAGNTCDDADDAEGCIFTQGLLVQDATPEEIDAAVAEGAGGAGGNAGNAGGDAAADDGAAACPAGNATESAANSTSATTRLRARVRRSTPVARSPLSKAVLSQRGATATVRRQNNNGTADAGDDADNADNNAGNDAATGTTNNVQTFTGDLGGPAPPVSSSASSDKPFEVNGATFLNAGAALQRSCAVQHNACADAANSGAEDVSVADCDAQEDSCLAAASLKKLRRASGLNAGGRRMRIAASGLVRGRQAFDFGECADPSIQFAEGLDGRAEASFGPAGDFDHGSAQNINIISGFICGQLGSRCQADEAAVAACEQGQADAQGLEGQEAADAFNSALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XRX2</accession>
    <name>A0A1B7XRX2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_13716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151008.1">
        <property type="nucleotide sequence ID" value="XM_018308690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XRX2"/>
    <dbReference type="GeneID" id="28872797"/>
    <dbReference type="KEGG" id="chig:CH63R_13716"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13716"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR02490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="117" mass="12840" checksum="00700C6CE89D2C16" modified="2016-11-02" version="1">MTSSSRVCRLRMCPEPDMVTIIYIGISYRDITAANTGRRQTSHRPRSERRGCVAAAARGQEDRAADDGRWGPDNGDASSLFGGTQPEQEEAKTPSAKPNGTIGQDGTVHLGPRRWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV54</accession>
    <name>A0A1B7XV54_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152136.1">
        <property type="nucleotide sequence ID" value="XM_018307719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XV54"/>
    <dbReference type="GeneID" id="28871826"/>
    <dbReference type="KEGG" id="chig:CH63R_12745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12745"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="305" mass="32544" checksum="29BA9BFCF4E3646C" modified="2016-11-02" version="1">MTNTVAPIPRLIYGTAWKKSQTAPLVASALSAGFRALDTAASHHYSEEGVGAGLRAWLARNPAHGVPRSGLYIQTKFSPSPSTLPIPDQVHRSVAASFKNLAVPGDQFATEETEAAAAAADNDDGNFYLDCVLLHAPYPSYADTLLAWRALESYVPSRIRTLGISNVDLDELRALCVDAAVKPVVVQNRLNPKEAYNTPVRVFCRDAGINFQSFWTLTANPQLVKGHVVARVAAGAGVSNEVAMYGLVLGLRGVSVLNGTTNEARMKEDLEGVEKVAAWAEGDGAEVWKESLAAFKSVLGDPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVQ2</accession>
    <name>A0A1B7XVQ2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase mu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_12962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152353.1">
        <property type="nucleotide sequence ID" value="XM_018307936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVQ2"/>
    <dbReference type="GeneID" id="28872043"/>
    <dbReference type="KEGG" id="chig:CH63R_12962"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12962"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001726">
        <property type="entry name" value="TdT/Mu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00871">
        <property type="entry name" value="DNAPOLXTDT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR03835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="602" mass="67368" checksum="A27366FD89F065B6" modified="2016-11-02" version="1">MALELPPVYLLPTHLKPDELHELEEKIPSLTYNIQEANIVIGKISQRERALFELRRGKVLTDPIDATRISESPSATPRKRKRALSGSGSESTLYSEDGEKYGPVPMQTIKALANKSGNTNIVKVVKLAWLTDSLAQGEILPLRNYLLYEGRKKGTSETPTTAKGNGILSRAATDDLWQTHNSVCLEERRKYPADMHQATPSLLRQTTSEHDSVLKLPPIPSFLGSTFACQRPTPVDPPNGIFVDELKKIRLNRKMVGDQIGVRAYSTSIATLSAYPYAIATPQEVARLPGCGVKVAELWHEWKESGRLCEVDEAQADPRLSVVKKFYDIWGVGDITARDFYNRVESIADTILVHARNINPGFELVIVGGYRRGKQGSGDVDVVISHRDESATLHFVNKLVVSLEKSRHITHTLTLSNHNSERGQRPVSWKGNESKGSGFDTLDKALVVWQELEIESHKRYPKETKEKPHRRVDIIISPWKTVGCAVLGWSGDTTFQRDLRRYCKKQKSFKFDSSGIRSRVDGSWIDLEGGKLGKAPDMLTAEKRVFEGLGLEWVHRVKRRIPPCGRSCGEAEVKMACWIPPAFHWEESAPDAPKRAQSPFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWP0</accession>
    <name>A0A1B7XWP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_13298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152689.1">
        <property type="nucleotide sequence ID" value="XM_018308272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWP0"/>
    <dbReference type="GeneID" id="28872379"/>
    <dbReference type="KEGG" id="chig:CH63R_13298"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13298"/>
    <dbReference type="OrthoDB" id="10593225at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601133" evidence="3">
        <location>
            <begin position="18"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR04171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="413" mass="43153" checksum="DA2C5FAFA1E8FD3F" modified="2016-11-02" version="1">MGYITSLLTFCSARVLSSTCPWLCTFQAVHQTHSGASQEDCTHHSRLADGTQPNRTSNYLNISIIFRHGLSLFRLVWTPNTCRDLRLQFSPLTPTHDRYTLHSSFTMAGLSGTRRKSPPPMLKFNIDSQHQRRQAPPPPPPGPGTPPPTPPPPPTPPPPGEPRPPTPPPPGPPTPPPPPEGPPRPPTPPPPPPPPPPPTPPPRPRPRPPPPPPPPPPPPGPPGPPGYPGPPGPPGPPGPPGPPGPPGPPGPPPPPPPPPPPPPPPPPPPPPPALAPVLPSPQKTVFITLPPATVTVTATVIPAQNAGLSNGEANRNGGGGGINSGVSSGEGGGRQLQQPSININMTQGNPFSTGLVAATMGIMGLTVILSMLAAGFAFWRRRRRRQGQAQAMDLQGYDLGIDYGQNHEQPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XX44</accession>
    <name>A0A1B7XX44_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH63R_11035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152850.1">
        <property type="nucleotide sequence ID" value="XM_018306009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XX44"/>
    <dbReference type="GeneID" id="28870116"/>
    <dbReference type="KEGG" id="chig:CH63R_11035"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11035"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="888"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="903"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="916" mass="99973" checksum="FD772AAF813F3E40" modified="2016-11-02" version="1">MQANRGNAEALGRKAKLARSYQELLDEFSNKDLSSVGNYTLGRLIGKGSFGKVYLATHKLTNGSKVVLKSANKGDSNLAREIHHHRQFVHPHIARLYEVIVTENLVWLVLEYCSGNTILCHLGSTNTTDVPIGDELYNYLLEHGPLPVHKVQKIFAQLVGAVAYVHQQSCVHRDLKLENILFDKHENVKLVDFGFTREYEGKSNYLQTFCGTICYSAPEMLKGEKYAGEKVDVWSLGVILYALLCGELPFDDDDDSVTRTKILSEEPRFPEHLPPAAIPLLKSLLSKRPLLRPSLPDILTNPFLAEHAPAQQAILKVQRPAPFSTHLEKETLQRMRSAGVDIDSVIESVLAQRCDALAGWWTLLIEKEQRKVRRRERRRREREAENRSLRRLSAASSRLERIAPVLQEVDEDGGLTNRFIRLEDAPVTPRTRGRSERRSAHYSDFGDLPGLPEHSKENGSPNTEEPPPPIDKDSIRSASTSRNRRPVPPPKEGVIRSARSRGSTLHLVTTSEALATNGTPERPPEQQQKVRKKPSQAIIAHWKNWTHWFLENTRRGRHANKRGSHSTPNLVDKNGSVAGNSSKHSKDTSPRPQTSKYSTTDEAVSQVKAGLPRGVMANGHLNKALPGQRGSGGFNSPVTGAGSTPSHMPSRITTSYKRQSLSPSPMTPRTTMRRSSAGLRGRKSTSSSVSSIRSMPHHHHSHSKASSTSSNGSVSTSMSKNTLQRGQSPHHSVKVLPATPTTTAFPSNIRLVRGPGPPAPLALFNEGMPPPPISGMQAPGSPNFFSQGGGIQFAKRKRNIFKGPMLAFGGGGGASAGAGGGSATRSTGSSHSRSVSASGIGRRSGEVTIQEEEEGEEAEEEIEEVDAFSPVVGGPGERIEEQIIEDGETEAAGGQAKVDTDAVPVTPKTKVPPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYP3</accession>
    <name>A0A1B7XYP3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type dipeptide transport periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153393.1">
        <property type="nucleotide sequence ID" value="XM_018306552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYP3"/>
    <dbReference type="GeneID" id="28870659"/>
    <dbReference type="KEGG" id="chig:CH63R_11578"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11578"/>
    <dbReference type="OrthoDB" id="3472756at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.76.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Solute-binding protein family 5" evidence="1">
        <location>
            <begin position="47"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="472" mass="53411" checksum="CECBCE1DB74FE755" modified="2016-11-02" version="1">MTPETLRLSLENVDFRLPTQVTDDNSVTALKSLVFEPLLRWQPHGHVLPGLFDRWESSPDARTWHFHIRDDAVFHDGEQCTAADVVNYINGLLDSRDYFGMRWSYSRYFEQTQFSTEGSQTVKVVSSEPFADIVGVFCEFWPSRLDKDGKPVLGTGPFRVVEFEREDGIGRARLQRLNPTRHNAPHIIVASTEPSAAKRLQLLRAGEVDAALNLERVDNLDLLDFDGSLKWGRVTSTLSAIYYLNCTEGIFTSPEARLAANLAIDNEALVKEVYRGFALPSATIVSPFHLGFPQSGLKPFPFDAERAREILKGLDTSEPLVLRTPTYMPEHAQKISAFVASSLRAVGFEVEVRVETNRPEYARQIGLQKQIGSLALFDSTPNSTFRVLDDKISSSSHATWWLGYHDDEVQRLFHEARNKIHYEDRAVAYAETLKRLQENPPWLYVAHPEVVWATRRDVGLRIGHSGVLTLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYQ9</accession>
    <name>A0A1B7XYQ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_11598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153413.1">
        <property type="nucleotide sequence ID" value="XM_018306572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYQ9"/>
    <dbReference type="GeneID" id="28870679"/>
    <dbReference type="KEGG" id="chig:CH63R_11598"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11598"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR04895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="430" mass="45254" checksum="E46A930EE91AC132" modified="2016-11-02" version="1">MTAYRRYPPHPPQSLASIPHHPAKMLVRVHSLSLLAAIAASGGLAAAVPLESSSAFTTRDLPRPRFGSVPYGVSITHCTVNGKVALTFDDGPGEYTEKVLDTLEKNGNIKATFYLVGTNGNNGVANPTYTPLLKRMLGAGHQLASHSWSHKDFNTISRDEQVEELVKNEEIFAKVLGIVPTYFRPPYTHCDGQCISTLNDLSYHVTDYNLDTKDWVDGGANSKETYSSAINSANPASSSFIALSHDIQSFTVNGFVQYMIDVAKEKGFEFSTVGECLGDPASNWYRDPKSGEPSGGKEEPKPTTTSKSVAPTTTTSASTSTTSPAETKTTASSTTESETAKPSVTDKSASETDEPETETDGPTSTGVSPPTASRTVDGGANIGIPVTPTGTTGAPRPTSTNTVVEVNAAGRAVLSAGGALAGALAWAMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y094</accession>
    <name>A0A1B7Y094_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_12135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153950.1">
        <property type="nucleotide sequence ID" value="XM_018307109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y094"/>
    <dbReference type="GeneID" id="28871216"/>
    <dbReference type="KEGG" id="chig:CH63R_12135"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12135"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR05432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="60" mass="6917" checksum="6AF2B3D8618F32FD" modified="2016-11-02" version="1">MCYIPFYEVRCGQCGFIYMRDKNAMKRCGQKQPCKNAEQLSIGETTRGYCHLCLGFPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0P8</accession>
    <name>A0A1B7Y0P8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate dependent xanthine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_12258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154073.1">
        <property type="nucleotide sequence ID" value="XM_018307232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0P8"/>
    <dbReference type="GeneID" id="28871339"/>
    <dbReference type="KEGG" id="chig:CH63R_12258"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12258"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="62"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR05555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="418" mass="47419" checksum="397A45DDB8FA7E8A" modified="2016-11-02" version="1">MVVISPQKLSRQSRKIAQTCRTAMSFNVEPLKLEPGKRVKFGAKITNLDINNVSGEFLVPVDKDLQRLKNVVWNHKFVIVKGQRNLEPAKQWELVTRLDPEAGPQSPEIFMADFHPDGGGILKARGVTGVPGVENVHVIGKGYQGKEHYGLKDLNLNKSFSYENHYPTLGPEELEGGHTRFQGWHFDAPLYNREPPLFTAFRVIRLPRGPDVTIQWDNGSGLSMKSAPGLTPFFCCSQLYEELMTEDERQMADNSWVEYAAFPYEWNRKCKFFPTGLGIVSQGKELNEDELKGLRPDEAKIRRYPMVWVNPATGRKCFQVQANAARKLFIRRSPGDEVRVVDDVVEVRRILLDIQLRILKPEYILIPPEEEGDLLLWDNWATMHSRVDYPARYGPKLCHQAGTNASRVPVGPAAAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4Z7</accession>
    <name>A0A1B7Y4Z7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155630.1">
        <property type="nucleotide sequence ID" value="XM_018303607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4Z7"/>
    <dbReference type="GeneID" id="28867714"/>
    <dbReference type="KEGG" id="chig:CH63R_08633"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08633"/>
    <dbReference type="OrthoDB" id="4850092at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="422" mass="47037" checksum="8AFC3D64DD308C93" modified="2016-11-02" version="1">MEGHRERDLRQASRERDQAERQKWEMDVKVDQLRKDIERSFKADIRDAVNDIRKEIQTSLSESQSEPGRAPSRMDSSRRGYAGSARSVHGDRDVWVDRDGEHQDVLMQEIAKIMDGKRMLQPQDSTSGAAFRGGTQAGRGSARGSRIDPELRSEVETIIYDILGGSDPGQRHYRRPSSRSFNRGTASDDYDPRTEASGYPRNRYRDTHDGGVNPALANRYGLRRSPGQVTFDQNDYTIPSAAPSHPADERPWLGVPHRSRRPRRRGEDVAGPSDPRTYGPSLQQQPLATQANNLRTQPGTHAPDPRHWAGGSNGEAVSSAGATAMAYQDRMNNSGVRQGEQGNPARPLGRRGERVPAAAAAATYEDEDAGELFTDDDESDNGEVFPKRDATYPEFLAGHPDLRHQLPRVPDPRPHLRRVGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y4Z9</accession>
    <name>A0A1B7Y4Z9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA-associated factor 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_08557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155554.1">
        <property type="nucleotide sequence ID" value="XM_018303531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y4Z9"/>
    <dbReference type="GeneID" id="28867638"/>
    <dbReference type="KEGG" id="chig:CH63R_08557"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08557"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR07036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="346" mass="37057" checksum="5EEDE9177C95B112" modified="2016-11-02" version="1">MSQRNRSGRGSNRNNGSGHGEEVQLWESAKEKFHEIVSGVNQENDNLAELLKLDKKAAIASMDGGKPSGADLNKMEQNCRSGVKLSENNSNNIKNLIEQLKILKAVQQAKEAAEAPATTSTSSRTGSSTRNRDAASAAIYDFDGAGDSPVPSPIGGNSRKFGERGSNRDSMPPKADSVEPQGSTGSNTAGSSSGALGSSAASAARSKVSFSKGDKVAFKRKKDEPQQGEAPYDWILGEVVGVMGEGKSRRYKCLDVEPEDNVKPKEYKTFASGMIPIPAENQTHTLAKLEAGKMVLGLYPQTTAFYAADVVGTEPDGKTVNLKFHGENDSSTTHQVERRYVLEFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y5X1</accession>
    <name>A0A1B7Y5X1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_08866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155863.1">
        <property type="nucleotide sequence ID" value="XM_018303840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28867947"/>
    <dbReference type="KEGG" id="chig:CH63R_08866"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08866"/>
    <dbReference type="OrthoDB" id="4776128at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="41"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2546"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2828"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2881"/>
            <end position="2901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3002"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="3026"/>
            <end position="3411"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
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    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7C0</accession>
    <name>A0A1B7Y7C0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pth11-like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_09484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156481.1">
        <property type="nucleotide sequence ID" value="XM_018304458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7C0"/>
    <dbReference type="GeneID" id="28868565"/>
    <dbReference type="KEGG" id="chig:CH63R_09484"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09484"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF162">
        <property type="entry name" value="SATRATOXIN BIOSYNTHESIS SC1 CLUSTER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR07963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="389" mass="42539" checksum="3C8EB61950744FD7" modified="2016-11-02" version="1">MSAANPDAPLTGAAQTIDRQTLTAIIWICFSVASLFVALRLAVRWRQNRSLLADDYCILWAWACLLTMSALQTRQLDALYYTTHLAAGRIPVTAEAGPITEELTRWQFPIIKLFWTVLWSVKASFMALFYRLVRPFAVRRRLWYCVAVFASLAYVGCWLASTLTCSPPSDYFRAGKCNPPHEIWMQTFNVLYSTAVDIASDLMIMALPLTVLPSLQLDARRKVGLGVAFSLAVIIICVAVVRMTQIVRGGTVDLVGLAIWGAVETATAVVVGSLPPLKALLTRGVRKYHSSAKKPSQRYYAGGGHGSVPGTTAGGAGGGGGYGPDTRSRSVMVTESIPLDDMHRSSQMDGRIYVQRTYETHVEHDNSSREGDDDDEAAIVKGKTKAWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7U8</accession>
    <name>A0A1B7Y7U8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ank-repeat protein mbp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_09652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156649.1">
        <property type="nucleotide sequence ID" value="XM_018304626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7U8"/>
    <dbReference type="GeneID" id="28868733"/>
    <dbReference type="KEGG" id="chig:CH63R_09652"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09652"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="311" mass="35673" checksum="24F7FFC3C636D1ED" modified="2016-11-02" version="1">MGDTAPKDSSKDLSNRFAALTVNEPSQAFLEEFRNAPHERPVPRDEDPASYEAEPQTSIEDVLFAFTVLVNDLDRIQSQIEWIWSNHRNRKFDLADAAVATNTAISVARGMIEEVAPLLDAHDRGVSGVLNKFYLMICLQKGYTAEQVHLTNSRDNFNYNTYDIANQCYMVAFQLLQGFTDDLKPHHIPLVNEGMFGEYNPNSDRASKTGQEKFQEDTILLLEFFTELVTVIQLIPSYPVEDEFLREMRKFDKAPIVSFSLIITAQVFLDIHHTMRTATRRSFKEIVQEATVMDNSLGRHLEFHERLKINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y7W6</accession>
    <name>A0A1B7Y7W6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_09672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156669.1">
        <property type="nucleotide sequence ID" value="XM_018304646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y7W6"/>
    <dbReference type="GeneID" id="28868753"/>
    <dbReference type="KEGG" id="chig:CH63R_09672"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09672"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR08151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="140" mass="15650" checksum="704DAE45480EA704" modified="2016-11-02" version="1">MQRISNLPPNGHNGQVIERAGVGNIGAKDILIQPIEGMNPETSFQDLYAVNITSAPYNTQKGGWDHDGRVQMIGRNFLNFDPHGSHMISEDVARTTLAAFNAAFYTPHGKARAWKREELEPPSLENDQPRFFDLFMGNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8G0</accession>
    <name>A0A1B7Y8G0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_07091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156844.1">
        <property type="nucleotide sequence ID" value="XM_018302066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8G0"/>
    <dbReference type="GeneID" id="28866173"/>
    <dbReference type="KEGG" id="chig:CH63R_07091"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07091"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="111"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="597" mass="66591" checksum="07C8B0A30BA2252B" modified="2016-11-02" version="1">MSHAPDVEGDVKSKLGVSHVEHSNADYTRNIEARIRNPLLGISKPDLVAQVDAFCREFGFPDKQGVFLRGALAAQHPDSYASLDELTDDDRRALGREVTHRWRLPRDLYLSVALCSLGSAVQGWDNTGANGANLSFPREFGIDGPGHQALVGVVNAAPTLFGLLSAWAADPINDRLGRRGTIFLTGLFCVFPVLAQAFTRNWWGLLLCRLFMGLGMGVKISTIPVYSAEVAPAAVRGGIVTSFQLWVAFGIFVGFCSNLVWYRIGDLAWRFQLGAAFAPAVPVLIFVWFCPESPRWLMKKGRYQDSFRSFCRLRNTEMMAARDLYYAHRQLIVEKDAFGGRTLLRRMADLLTVPRLRRATLASSWIVVSQQFSGINIMAFYSSTIFEQAGYSTRNCLLASMGFGLVVFVFAFPAVYVMDTFGRRNLLLVTFPNMAWCLLAAGLCFLMDQGSSARVPLIAFFIYLFAAMYGPGIGPLPSIYFSEAFPLSHREIGSAFTICVNNAIGSALTLTFPELLHRIGPTGAFGLYAGLNMLAFVVIFFLIPETKQLTLEELDYIFGVPTRRHAAYQVRTWLPWVVRRYVFFDRSAKLEPLYHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y8T2</accession>
    <name>A0A1B7Y8T2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156950.1">
        <property type="nucleotide sequence ID" value="XM_018302172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y8T2"/>
    <dbReference type="GeneID" id="28866279"/>
    <dbReference type="KEGG" id="chig:CH63R_07197"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07197"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601429" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="151" mass="16463" checksum="5329F4F1D88D8D25" modified="2016-11-02" version="1">MLSLRPLRLLAALALSGTVGAEPYNTFDGPGFPACHDVAAVHDARSVDEIQSIVRVAAAACWKVHASGKAHRWHDTMCSDDPGTVIIRTEGVNVISGFDLAAGTRELRRLVRDDGDDEWLSASTSLGLLSVIVRMKFKIYPDSKVYVDQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y938</accession>
    <name>A0A1B7Y938_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157087.1">
        <property type="nucleotide sequence ID" value="XM_018302309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y938"/>
    <dbReference type="GeneID" id="28866416"/>
    <dbReference type="KEGG" id="chig:CH63R_07334"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07334"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="247" mass="27676" checksum="B3A5410C6CBE9CE9" modified="2016-11-02" version="1">MMVKAIGNRLYRAPVRMEQAHRILDIGTGTGIWAIAMGDIYTNAEITGIDLSAIQPQWVPYNVRFEVDDIESPWIEGRKYDFIMCRYMVASIKDWPGLVDNIYDHLNPGGWVEFQDVTTKFYSVDGTFTDEHATARWMDSFSAACLAMGRDTTVAPRLGAMLEDAGFENTHSECIKTPLGPWARGGHFRELGMMNLVLTLDGLEALSLKLFSELLKRTETEIMAELAAVRTELTTCSGGAFHAMFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y9I4</accession>
    <name>A0A1B7Y9I4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157261.1">
        <property type="nucleotide sequence ID" value="XM_018302483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y9I4"/>
    <dbReference type="GeneID" id="28866590"/>
    <dbReference type="KEGG" id="chig:CH63R_07508"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07508"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="164" mass="18058" checksum="77E38EE33E93C0DF" modified="2016-11-02" version="1">MGKPRGSNTAKTKAGAGANNGSNTKSTTLSTPNVPPAWPQFKPPLPVTDLVPDKLDSCPDKIVLIRNFWPKSLCSSYVTFLRGLPLITTPGRPKRGEAVRVNDRFQVQDAGFAQRLWTETGLRESLGQEDIQGLWGGEVVGLNPNIRIYRYSKGQYFDAHCKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YA74</accession>
    <name>A0A1B7YA74_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_07727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_046754145.1">
        <property type="nucleotide sequence ID" value="XM_046898189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YA74"/>
    <dbReference type="GeneID" id="70904779"/>
    <dbReference type="KEGG" id="chig:CH63R_07727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07727"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="26" mass="2882" checksum="A27EA8DE540B2202" modified="2016-11-02" version="1">MPPLSKSRPLRSMPPTRAERLAMSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAA6</accession>
    <name>A0A1B7YAA6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_07573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157326.1">
        <property type="nucleotide sequence ID" value="XM_018302548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAA6"/>
    <dbReference type="GeneID" id="28866655"/>
    <dbReference type="KEGG" id="chig:CH63R_07573"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07573"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="73"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR08808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="457" mass="50645" checksum="8DE60A9B30B94ED0" modified="2016-11-02" version="1">MQPSDLVKMSREIISSRTTIHTSLLFNARRKTFDKDVSIIVDSTTGTIEDVYQRADGNDLAVNRRDIDLRGKVVMAGFVDAHTHVFLHSYDEASSTVQMRDESIVERIVRATNHLRAALLSGYTTYRDLGTEGMRSYDANLRDCVNRGLLPGPRLFVATECLASTGSYEVRHENTLAKLPRISDACDGPVGVRQAVRRRVGDGADIIKFYADYRRKVMRFPPPIQPPRAAIPFLPSDPNPAVVMFNQEEMDEIVREAKLGGLPVACHAGTARGALMAIKAGVDTIEHCNETTDEVFREMRRRGTIFVPTLAVLRNSPDFDNISKRVKRAHDLGVRLAAGGDTGAFPHGEGALEMELMIRAGVPVPDVLEACIIGGWESCGKKKSGFLFGSIEKGYRADIIALETDPRTDEGALRKVNFVMKDARVWKRDGRPVDFVEEQAETRPASGSEEESDWVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAK1</accession>
    <name>A0A1B7YAK1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_07750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157502.1">
        <property type="nucleotide sequence ID" value="XM_018302724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAK1"/>
    <dbReference type="GeneID" id="28866831"/>
    <dbReference type="KEGG" id="chig:CH63R_07750"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07750"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="675" mass="73137" checksum="716523EE557F9ED0" modified="2016-11-02" version="1">MMSARFSRALPRATSSVARSAGFARQPFASKFARYESTATDGKVTGSVIGIDLGTTNSAVAVMEGKVPKIIENAEGARTTPSVVAFAQDGERLVGVAAKRQAVVNPENTLFATKRLIGRKFTDAEVQRDIKEVPYKIVQHTNGDAWVSARDQKYSPSQIGGFVLNKMKETAEAYLSKPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVVNEPTAAALAYGLEKEDDRIVAVYDLGGGTFDISVLEIQNGVFEVKSTNGDTHLGGEDFDIHLVRHLVQQFKKDSGIDLSGDRMAIQRIREAAEKAKIELSSSLSTDINLPFITADSSGPKHINQKLTRAQLEKMMDPLITRTIDPVRKALKDANLQAKDIQEVILVGGMTRMPKVSESVKSIFGRDPAKSVNPDEAVAIGAAIQGAVLSGEVKDLLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADFQTAVEIKVYQGERELVRDNKLLGNFQLVGIPPAHRGVPQIEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSDSEIQQMVEDSEKYAETDKERKGAIEAANRADSVLNDTERALNEYAEKLDKAEADGIREKIASLREYVSKSLAGEGNATAAEIKEKTDELQVASLNLFDKMHKARAESGEQPTQDANASENKDGEKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAW1</accession>
    <name>A0A1B7YAW1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_07934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157686.1">
        <property type="nucleotide sequence ID" value="XM_018302908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAW1"/>
    <dbReference type="GeneID" id="28867015"/>
    <dbReference type="KEGG" id="chig:CH63R_07934"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07934"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601483" evidence="8">
        <location>
            <begin position="23"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="628" mass="69045" checksum="A9FCBA7FC2E2DCC7" modified="2016-11-02" version="1">MGPLYTALVLLPTLWIASHLRSLYNNYRAALLTGLPIIICPFDPESFIIAIFSVPARPLLKRVLPARAFAAVELTIFGWEFRDKAAVHARVGPAFVVVTTGLNQLMCADPAMAHAILARRREFVQPAISIKVMSFLGMNILTSNGESWSRQRRIVAPALNERISPDVWRETAEQATFLVDLLLSPPSSPSSCSSSEPSPPHTPGTSDTIPGLRSVAINVLTRIAYGHRKPFALPSLPRDPRAPMSYVDAISLVTQLLVPSAFVPAWLLRLPVMPRLLRTLGAALARMPALTADMLDQERRRAAEQQQQQQQDTTATGGNHAPDTIMSMLVRLSDQEKKSQAAAASASGDKKTAAATANKTYLTEDEIAGNLFIFTAAGFDTTANTLAYAVTLLAAHPEWQAWIRAEIDAVLGPPGTQDDDDDDGKHEELPDYATAFPKLTRCLAVMYETLRLFPPLTHLMRSNETTQTMFYHSTTDTSSSSSPSSFTLRAPCAIYINTVALHTSPSTWGPDALTFNPARWLQPSVSGDNDSEAPQQQQQQHLMTPPRGAFLPWSGGPRVCPGQKMSQVEFVTVIATLFRRCAAEPVPREGESMPQARQRLLDLTQDSQPILTLQMNRPQDVRLRWSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YAX4</accession>
    <name>A0A1B7YAX4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_07987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157739.1">
        <property type="nucleotide sequence ID" value="XM_018302961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YAX4"/>
    <dbReference type="ESTHER" id="colhi-h1vj64">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28867068"/>
    <dbReference type="KEGG" id="chig:CH63R_07987"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07987"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008447764" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="49"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR09222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="589" mass="63299" checksum="140434C949CEA580" modified="2016-11-02" version="1">MLMYIRNTHVAALALVALASQARADCTPQLPTVDLGYAVHQATYNESGGLFTFSNIRYATAPRFGAPTPVTVVNRTVNDGQTPGNCPMGSPPWLSLSPQYQAGQLSLDEVNATFAGIRGLSPSSDPSLIKQYLNTPITVPASTITEDCLNLDVVVPEKIFKSTNNSSAGGERPYEPTALTDCDAAPVLVWIYGGGYTVGDKNYCGNPATLIAKSQEDGSDGIVYVALNYRLGLFGFISGTEYEEQGGVSNIGLRDQRFALQWVQENIHLFGGDPDNVTVLGESAGAGSILHQLTAYGSTSGAPFRRAILQSPGFEFITGNGSKAAGKYARALEWASYFSNSSVGTLDDLRKLPYDVLDKVNQVTISTAYWGGFGWGPTVDGDFVPDLPGLLLSQGRFDSSVAVLGARNSDEGFIFASPLIEDEEDYLSLLLTPLLPDASDEVVDYITTQLYPAVYDGTHPWTTPLARASATVADTWFICNNYFLNKALGGVAYNYLFDVPPGHHGNDIGYTFFNGETTYNGLPVNASVADTLQAYLTAFAKTGSPNQDGLPEVPLYGDDAAVVSLYNRTTVVDTAVAERCDWWQKAFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YCG2</accession>
    <name>A0A1B7YCG2_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="6">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_08275</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6"/>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR09510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158027.1">
        <property type="nucleotide sequence ID" value="XM_018303249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YCG2"/>
    <dbReference type="GeneID" id="28867356"/>
    <dbReference type="KEGG" id="chig:CH63R_08275"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08275"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="12">
        <location>
            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR09510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="489" mass="54556" checksum="0E87456F946E17D1" modified="2016-11-02" version="1">MATDGKSAGPSPYDTYQTSLTARYCSPAMARLFSQRSRHSQWRKLWLLLAESERELGIETITPEALEQMRQHLEVTDQDFEVARVEEKIRRHDVMAHVHAFGAVAPAAAGIIHYGATSCFVTDNAELVLMRDAMDLLLPRLAKVISNLSKLAREWKSTPTLAYTHLQPVGKRAAQWAQDLVFDLESIEHVRNGLLLRGAQGTTGTQASFLEIFGGDGAKCDQLNELLCKKAGFPACYDVSTQTYTRKVDLLVANAICGLGATAQKIAGDIRHLASWQEAEEPFEVNQIGSSAMAFKRNPMRSERVSSLARELLSKQATTANTLAAQWMERSLDDSAVRRMDLPEMFLLADAIIGSLDNITDGMVIYPQVIASRVQEQLPFMVTENIIMKLCAKGVSRQEAHEQIRVLSHQAARVVKLEGKPNDLISRIKATEFFQPIWPELDAMMKPELYIGRSAEIVERYCGVEGVAEKKIQRYRAIFEKSATTELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEH0</accession>
    <name>A0A1B7YEH0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class-III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_06124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018158949.1">
        <property type="nucleotide sequence ID" value="XM_018301099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEH0"/>
    <dbReference type="GeneID" id="28865206"/>
    <dbReference type="KEGG" id="chig:CH63R_06124"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06124"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="466" mass="50288" checksum="DF189D39C8576445" modified="2016-11-02" version="1">MASESTAAFWAKTDKYLMSTGVPYSPIIISRAKGTKLYDDQGRQILDFTSGQMSSLLGHSHPEIVEVVQKYVAELDHLLSNMITQPVADLAERLGKLLPAPLEKVCPLCYMCILRFPSAHLACYPQSFFLNTGSETTEAAIKMAKLHTGKFEIVAMSASYHGLTQGSGSATYSAGRKNGGPAMPGQLAFPAPYAYRSVFRKADGSYDWEAEMDFGWSMIDRQSVGSLAAFILEPILSTGGILDLPAGYLRRISDECKKRGMLLILDEAQTGVGRTGKMFAFEHDGVVPDILALSKTLGCGLPLASVSTTAEVARGCKEAGFLWLTTHLNDPLTAAVGNKVLEIVVRDDVAVKATARGEQLRAGLLRLQDKYWCIGDVRGRGLLQGIEIISDAETRAPGSDLGQAVSDRAMELGLSCNVVNLPGMGGVFRLAPPVTVTAEEIEEGLRILDEAFGHVLEQREKTIPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YEZ0</accession>
    <name>A0A1B7YEZ0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_06278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000004">
        <property type="protein sequence ID" value="OBR10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159103.1">
        <property type="nucleotide sequence ID" value="XM_018301253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YEZ0"/>
    <dbReference type="GeneID" id="28865360"/>
    <dbReference type="KEGG" id="chig:CH63R_06278"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06278"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="167" mass="19060" checksum="FCEBE3A9CAC4F89E" modified="2016-11-02" version="1">MATAVTRRATSRVTFESAEQVRKWGRSWRLRREVEAMAYVRRKTSIPVPAIIDVCLDDDPEKEDCWFVMERLPGCQLGTAWPEMDDKARSETIRQLRSYLDELHQLRHSDPGFIGSVSGGPSYDHRLTNMRTCGPFASVAEFHDFLVAPRPGLPTPRMVRQVSKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YGV3</accession>
    <name>A0A1B7YGV3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_03687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159908.1">
        <property type="nucleotide sequence ID" value="XM_018298662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YGV3"/>
    <dbReference type="GeneID" id="28862769"/>
    <dbReference type="KEGG" id="chig:CH63R_03687"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03687"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000035">
        <property type="entry name" value="Putative Lipid phosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF84">
        <property type="entry name" value="PHOSPHATIDIC ACID PHOSPHATASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="137"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="408" mass="43893" checksum="5A0C2B0C7F045135" modified="2016-11-02" version="1">MGIFGKRREAAAVPANGHANGHHNGTSSKRHAAEPYTMSRRPSFGQWLKGTLLDIITMVCMGAIGLGIYMAPPAPNRSFAVTFADGEVVYPQFAYPMRNEIIPIWLAAFLASVIPICIILLMQIRIRSFWDVNNAVIGLLYSLICAAVFQVFIKFLIGGLRPHFLEACQPDLSRVTASQGGIARTGYSAAGFQSLYVTKEVCTGDTKEINDSLESFPSGHTTAAFAGLGYLFLYLNAKFKVFSDYHPAMWKLIITYIPILGAVLIGGALTIDEFHNWYDIFAGAAIGIVFAFSSYRMTYAAIWDFRFNHIPLNRGQAFTYGADAELYDAVFTRKAGWGKRGAGGLVHGHEKHHGLGGSGHGGHGNGHGAATGMHGAGTTGAAGVNDYGEPVGSRKPIGSGSRHPDAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YI06</accession>
    <name>A0A1B7YI06_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_04009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160230.1">
        <property type="nucleotide sequence ID" value="XM_018298984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YI06"/>
    <dbReference type="GeneID" id="28863091"/>
    <dbReference type="KEGG" id="chig:CH63R_04009"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04009"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="504" mass="56166" checksum="B148BCC793E79E6E" modified="2016-11-02" version="1">MTLRSVIGRRFIHDVVGNMTARHPPSDPLVVILGSTGTGKSELAVELATRFNGEIINADAMQMYKGLPIITNKISPEERRGVPHHLLDHVSLDQPTWIVEDFKREANRVICDIRRRGNLPIVVGGTHYYTNALLFEDTLVGADDGKPKDGDVKGDDADDGAASFPILDEPTDVILAKLREVDPVMADRWHPNDRRKISRSLHIYLQHGRPASEIYAEQRERKTAETSPDGGSPVSPWQTLLFWVYSDPDVLKKRLDRRVDKMLTAGLNDETQSMYDYVRAKEAAGQQVDYTRGIWQSIGFKEFSAYLEALNTSGPSSTDPSALDALKASGLEEMKTSTRQYAKYQTRWIRTKTVPLLQERPGALDHFFVMDSTDVARWSVNVADPAIDVAGRFLRGEALPAPADLSATAREVLREATVQTERTLCRRTCDICKTTCVTEQDWAKHVKSRRHNVILKKTKRRALSAAERPLAVVPVDAPGEKESRAADRGSSPEVDGLGMFDVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YIP9</accession>
    <name>A0A1B7YIP9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMI1/KNR4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CH63R_04222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160443.1">
        <property type="nucleotide sequence ID" value="XM_018299197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YIP9"/>
    <dbReference type="GeneID" id="28863304"/>
    <dbReference type="KEGG" id="chig:CH63R_04222"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04222"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="158"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="533" mass="58727" checksum="3BF7C87AB282CBC6" modified="2016-11-02" version="1">MASSFGAAFRSLWHDLTSYDRHSTIDSPHRTGRHVPLNRQSGILTSVATASESRADVSAPFAEDYNRFSRENSYQGGGMPYTPTSPNPSAPYSPGLRSQSARRESQQDGFELQGPGDVPMQSFQDGSPPPPPVSHSWKKIDAWAEEHYPELWDQLCEGCTDNDLNELEHQLDCSLPLDVRESLMIHDGQERLGMPTGIIFGSMLLDCEEMVQEWDQWRKVNHEFLSEAAYARPAALPKALGSSNQASSSRTPASPAAANNGSWRQELISRQESIPPNAVQRSYAHPAWIPLVRDWGGNNLAVDLAPGPNGRWGQIILFGRDYDTKYVIARSWAHFLAMVADDLSSGKWFVDEETNELKLREFKETRVEPPYFGILRWRVDQKYGRRAAKRKSVVAPNRAGSPAGSGANSPYASPTTEPNGEQRGRSMQRLGGTSPMASPIRPGYGKSSPLARVAEETPLPDLEANGLKPTKLVEVETPRPSEDNGKGSLVSLLSHVETAEGEGKENNNPAKTNGKANGKQPEVLEESMKEIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YJW8</accession>
    <name>A0A1B7YJW8_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Got1-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_04632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160853.1">
        <property type="nucleotide sequence ID" value="XM_018299607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YJW8"/>
    <dbReference type="GeneID" id="28863714"/>
    <dbReference type="KEGG" id="chig:CH63R_04632"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04632"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="146" mass="15894" checksum="7A95C3ED3A25D9A6" modified="2016-11-02" version="1">MSSMWMSDTQKIGVIFCSGGGFFLIGGVMLFFDRAITRLADLRLRACQILFLIGLTIIIGPQKTLLFFARKQKAKGTAAFFAGLALILLRWPLIGFCVELYGIMVLFGDFLGTIAAFARNIPVIGPYIGAAVDRSGVGRRNAELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YKY7</accession>
    <name>A0A1B7YKY7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pectinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161131.1">
        <property type="nucleotide sequence ID" value="XM_018299885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YKY7"/>
    <dbReference type="GeneID" id="28863992"/>
    <dbReference type="KEGG" id="chig:CH63R_04910"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04910"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="242" mass="27997" checksum="AC7FA3B556580479" modified="2016-11-02" version="1">MTTATTATFHPFPHLPAELRARIWELTVEPRIVEVRVVYHRPSPTNVEGSEPVVKWPPQTRYLCSPTPAPAQLQTCREAREHLTTCPNAVYRFQKAFSELARTPYNGPDPVSEGGPQQERYAWFNFDYDMLSIGKTDLHELRAIAYQIRRLRLRRVISDEYFSRTESLLISRWFRNVTEVHLICLEGIRVGYLMTEDMEFPCGPENVYLVDLEEGGLMMNSIDLDAMVIREDEERYGLGEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YLX2</accession>
    <name>A0A1B7YLX2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_05333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161554.1">
        <property type="nucleotide sequence ID" value="XM_018300308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YLX2"/>
    <dbReference type="GeneID" id="28864415"/>
    <dbReference type="KEGG" id="chig:CH63R_05333"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_05333"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="96" mass="11157" checksum="6A9FAD2E5662E97D" modified="2016-11-02" version="1">MHHLLLRRLDEEFRSASREPDALRQIGYRNPKPDDAFGFNLQFGYEGTYWDHIANFNQERSDNFNQAMRAVTINNIGEIPKSYPFASLAEDGGFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YMC0</accession>
    <name>A0A1B7YMC0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_01921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161712.1">
        <property type="nucleotide sequence ID" value="XM_018296896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YMC0"/>
    <dbReference type="GeneID" id="28861003"/>
    <dbReference type="KEGG" id="chig:CH63R_01921"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01921"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="312"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="646" mass="72468" checksum="4A100EF2BDD6A01A" modified="2016-11-02" version="1">MANPLAQAQVSAPAVSQAAMPLAVVAVVDENPPTQCLPPPPGPLRKPRRRNHHELYDKIARIESLLSQHGVHPEPETGPGPGKDRDPRFCPQSHTVEMEGVRESAETRPPRAQVAKGQLVQTWNGGLEFRDSKAMAVVFEDTQFHTISALIDVEFDQATWLPAVEAPQNGRRSLDSNGSSSASQPPVCVPSAHTINVLWDVFLDRVDPVTKIIHAPTFRMRVVEAANNFTNTPLATLALLFSVFLTASGSLSEHEHWEKLSLCKSDAVAEYTLGLKRALTEMNYLKNHNLDVLRSLALYSLFQQTRYGLHDPWVLNGVVVNIAYRMRLHLDGSHANLSPFECEMRRRLWWQIVILELRSGGAFGTGSHLLPSGRDTRIPLNVNDEDLIPAMIVEPRPRDGPTEMSFCIMTYEAKKHVLALPRLLSIDDVLWSQMPSPTHPYGSSSTERSETINLLQTFMEEEQRTMGPLEDRLCPDPATNPLHAMARWGREALSRIAQLIVTPMEEASEWGTEVHGPDDNFFRINLAANEEALLARQAAGRRFAWHADIDFRMQTFYYLGAQLRTRVAGSLADRVWAVMERTYALRGELWELKDKENMTLANLLLAAWERRVAYFAGEGVVLPEPPFLTRLRDEVMTIKAEALGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP08</accession>
    <name>A0A1B7YP08_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162270.1">
        <property type="nucleotide sequence ID" value="XM_018297454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP08"/>
    <dbReference type="GeneID" id="28861561"/>
    <dbReference type="KEGG" id="chig:CH63R_02479"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02479"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="7">
        <location>
            <begin position="83"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="230" mass="24071" checksum="74CBF98D416AD6B1" modified="2016-11-02" version="1">MPNRTTLPAFALAPGISRVPTHLFGPSTTTSHHQVRLFSSTALRHGNDNNSNSSSRNDSNDSSNPRPSPSLTHVSPTTGSAHMVSIASKQPTARVARASCTVTFSSPLALRLIRASQVKKGDVLGTARVAGIMAAKRTPDLIPLCHPIALSHVAVEVEPASAADDETVLRVEATVECEGKTGVEMEALTAAGAAALTVYDMCKAVDKAMVIGGLRVVLKDGGKSGRWEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YP99</accession>
    <name>A0A1B7YP99_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase GroES-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH63R_02586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162377.1">
        <property type="nucleotide sequence ID" value="XM_018297561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YP99"/>
    <dbReference type="GeneID" id="28861668"/>
    <dbReference type="KEGG" id="chig:CH63R_02586"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02586"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="356" mass="38394" checksum="AE295D1839E7743F" modified="2016-11-02" version="1">MSATGSMRAVVFNGPQNVSVEQRPIPTIQDDGDIIVKVQATALCGSPRELHVFRGHQPSETGFIMGHEFTGTVVEKGAAVATLNIGDRVVTPFTSSCMQCFYCKNGYTSRCVRSKLFGCGALDGGQAEYVRVPDADGTAITAPSTISDNALVLMADIWPTGFFGAKSGFSLLKEEERSNATAVVIGCGPVGLCALIAALEYRPKHLFAIDSVDSRLELARSLGAEPLNFKTDRAGMERRIKEATEGRGADVVIEVVGLSPALRTAFDVVRPWGVIASIGVHNGEIPWTGTEAYGKNLRLQMGRCPVRAIFPEALALLEKKQDKLGFMFDRIMPLSDAVEGYALFDQMQVQKVIFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YQR3</accession>
    <name>A0A1B7YQR3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162809.1">
        <property type="nucleotide sequence ID" value="XM_018297993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YQR3"/>
    <dbReference type="GeneID" id="28862100"/>
    <dbReference type="KEGG" id="chig:CH63R_03018"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03018"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="120" mass="12640" checksum="9B641C9CB855C92D" modified="2016-11-02" version="1">MLAPEETSRGRRRISPTTTAVPPPRPISRRRAHSLRRASYSFPHLTSALSGDSLSGPAPANEACRQRILCLTSAKPPAAATNHRPLQATPQQGVVHRGISGGGGGTLDAMPSANGFWNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRA9</accession>
    <name>A0A1B7YRA9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163106.1">
        <property type="nucleotide sequence ID" value="XM_018298290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRA9"/>
    <dbReference type="GeneID" id="28862397"/>
    <dbReference type="KEGG" id="chig:CH63R_03315"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03315"/>
    <dbReference type="OrthoDB" id="5232980at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="489" mass="53692" checksum="12AF6C4AC325C86F" modified="2016-11-02" version="1">MDVLSAPSIAYMPSGWASHDTRDRHALLCTVWPQYLTLEEASDIIEQFNGLGWVRDNQLLWSGVEYAEVERTANEHNMQTLRVAMGPLMDPGHPRCLKSKKKEKAWSKYIKGASLIFAWRISQGEVATIMTPPPPDCFHPSEMTNLQDIELPVLRGDLGNRPVSKIFLWHPTVEGAQSFKYQIWPQDHTSSWYQTFDPRAKDTKTWRVVSKHRVSTKWAVNTTVRRLVTLETFGKLKRLSSNVRISINVADKMVLLLKLFYHSAVLLLIIARLVLQVVVAEEAAPGETGEVTSASSSKVKPNEESRITYASKINQPPSRLTTVNISAMTVSGSSSTDKVASSEVDQGNRLPVHKVSSVDQPPSSPTAVATSAVANPGSSFPDTMAFSGASHNNKPPALKVSNADQRPLVLATSSSFAISDPGSSSAPAEGSSSSPTLGKRAAKALRKLQRAEVEAQVPISNANGKKTKKKSPQYHNKMGWQRQGLTFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YRQ9</accession>
    <name>A0A1B7YRQ9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_03453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163244.1">
        <property type="nucleotide sequence ID" value="XM_018298428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YRQ9"/>
    <dbReference type="GeneID" id="28862535"/>
    <dbReference type="KEGG" id="chig:CH63R_03453"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03453"/>
    <dbReference type="OrthoDB" id="4846778at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR14727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="213" mass="23832" checksum="E6439F9F67E9A3B0" modified="2016-11-02" version="1">MIDHNTPTTTDEDVQPQNYLRIPGLVFDDVPALIPQAHSAALRFLQPADFDLGMSYGEYYELLEPFDRVAHRLVDVFDYCVQVFRRGPGVPTAFSTAPYSPRSAGAADSAGENPPAAGSAAAFWGEFFDRVLDHLGPTAEAVGLCSLDVMWIVHLYTRAWQGTGKARRAAGRAHWRRANIRHLHDLLEEWFGMLRARGVAWTDVFGELFEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YSC2</accession>
    <name>A0A1B7YSC2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal hydrophobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_00117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163454.1">
        <property type="nucleotide sequence ID" value="XM_018295092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YSC2"/>
    <dbReference type="GeneID" id="28859199"/>
    <dbReference type="KEGG" id="chig:CH63R_00117"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00117"/>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601912" evidence="4">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="104" mass="10736" checksum="52AA713C56C4E110" modified="2016-11-02" version="1">MQFTVAIVALFAGVALSAPVIEERQVPYIPCSGLYASSQCCATDVLGIANLDCGTPPSAPASADEFSAVCSAIGQRARCCVLPLVSGVQKMPKLPTHTIANVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2024-10-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUN1</accession>
    <name>A0A1B7YUN1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CH63R_00931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164268.1">
        <property type="nucleotide sequence ID" value="XM_018295906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUN1"/>
    <dbReference type="GeneID" id="28860013"/>
    <dbReference type="KEGG" id="chig:CH63R_00931"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00931"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OBR15751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="114" mass="12659" checksum="B1B9F08E2CEBC9AC" modified="2016-11-02" version="1">MQARKQRPSGNSLCACRFGYSRLPQRPAFEFESLGCDAGQALRRSGGLRLGTDPEKPETRGLVSALPLAQYRVPSQRMPGLPAVDAIQDAWVRGAADETVRIALYYRLLVWPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YUV6</accession>
    <name>A0A1B7YUV6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_00922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164259.1">
        <property type="nucleotide sequence ID" value="XM_018295897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YUV6"/>
    <dbReference type="GeneID" id="28860004"/>
    <dbReference type="KEGG" id="chig:CH63R_00922"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00922"/>
    <dbReference type="OrthoDB" id="5426982at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="366" mass="40839" checksum="727CE9C340EB9A50" modified="2016-11-02" version="1">MVNMELDKNAIYTFLDQHRHAKHLDPSPTAYGGGPDSGQGQKVLSENDQLLEFFDLASFRRDYEYDPDPSPIMADGTTLSVPDSGSTETSSVRTPMTLQSSPGSPLTDHDTIISEEYENEPAGINDFTSPHDPFLFPRLDQKPNPPRKQNLWVPKKRSRSNSPNGHKRVVKDPIRTNQVRSVGSCTRCRIQKVTCTPDGTCDKCIKAFPMDHASSSCIRRDFAGVALDLSSARFAGLNRENELRAKHSLTLSQPRFVGNIHRGHVMFKRGHHSVKLSIALRNYCCMAENAQQVLHQGCVFARECSGVPSYDELIRWGEGIAFPEDKDTFEGLIEQFIKDYSAPCRSGGSPKRPQVWDSSGARTISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YVB1</accession>
    <name>A0A1B7YVB1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164494.1">
        <property type="nucleotide sequence ID" value="XM_018296132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YVB1"/>
    <dbReference type="GeneID" id="28860239"/>
    <dbReference type="KEGG" id="chig:CH63R_01157"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01157"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="186"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="495" mass="56716" checksum="6B4380D7EACE09B4" modified="2016-11-02" version="1">MAEFDVYESLETQHQFWEELDDVVTTQYQSHDLIDETLRAWLYLTSRFREKFPETEDDVAVCCEKLLQCQLFRDNKDYIRTQIIYSLLQEDDPASLHVIVLFLLLDGHADESTYSRMIEEACFPRLLELINGRKDQDLRLHRLLLELMYEMSRIERLRTADLLQVDDGFIAYLFQIIEELSNDVHDPYHYPIIRVLLVLNEQYMLASTDVAADPTSPTAPLTNRVIKCLSLHGDSFRTFGENIILLLNRETETSLQLLILKLLYLLFTTKATYEYFYTNDLKVLLDVIIRNLMDLPDEKISLRHTYLRVLYPLLAHTQLSRPPHYKRDEVLKVLRILGGFGNSHFAPADETTVRLVDRVSKVKWLIDQEPSGEAEVARKFLGISLSRSQTASSVSVVDVAAVMEKPGVITPSRKAEAEAEAKQGEENAGRVAVRAKKPLPEVPKHRHGIPVGPTSTSTLHLNGHRKIPPKAPPPRRRTRLKPVESVADDAPTPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YW77</accession>
    <name>A0A1B7YW77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_01481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164818.1">
        <property type="nucleotide sequence ID" value="XM_018296456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YW77"/>
    <dbReference type="GeneID" id="28860563"/>
    <dbReference type="KEGG" id="chig:CH63R_01481"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01481"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="521"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="767" mass="87935" checksum="368A36F25CF341AC" modified="2016-11-02" version="1">MAVQTKANTVLEASAGAPGETATATADAQNEPTGITSPDVTNYEEQEEPQREVAAHGSDVDHCTETKRAWIGYRLEYRNRWTGDLISERTYEKGNEPLEQETGGPIFEMITLYKVSTHSLDPAASMPITSQALPTRHIRIYSIAIINALQSVVRYYPGQDFSGESVVVQKPYPVLVHYYDELQQFRRDCLEKAPHDLCDRERDAAEHLEVLLAFLDEEVMWEVKQEQERNRRGFATFEWRWVAYKPGITVLDKTDTGEWQASVVHSISGGVFENPPKDWEVKLWCMDYDGENIERIWSSPVTWSKFDGERSDSKTGRETKFFDPTLDESYLDVDVVVKLVETGKKFCSMVQKQCFHHKGKAACFPFNEIEGLAMVDLDSYYIMCPDGIPPIVGTDDLRNWSTECTCEICQTRKQRLDRKIAPLFSTFGHKDIETGLTDHESLLLPSTVVTYVFRTRTWEYVHVKNLHPPQFDDDMISHLVMSEQRLKTLKALSKSYARVNQHGEGMKNSKWSADFVRGKGNGLIFLLHGKPGVGKTCTAECIAEFTRRPLMILTSSDIGTDPKQVEHNLTSNFKRAMSWGAVLLIDEADVFMERRTTSDLTRNSLVAGFLRALEFYDGILFLTTNRVGSFDDAFISRIHVQLYYPDFTEDERQRVWQTFIDKLSRERGDTMRMTIDAKEYIASTRKQGINWNGREIRNAFQTAVALAEYDAEKDSEGKIMVTDNHLRAVVELSKDFKGYLTDLHRRDEERRAEDRYERLATYHGDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWP0</accession>
    <name>A0A1B7YWP0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164974.1">
        <property type="nucleotide sequence ID" value="XM_018296612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWP0"/>
    <dbReference type="GeneID" id="28860719"/>
    <dbReference type="KEGG" id="chig:CH63R_01637"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01637"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="132"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="578" mass="63900" checksum="EEA9CB0DF00CE122" modified="2016-11-02" version="1">MEHFRDTAFGHAMQLMTGGTVPQLQYLDERSRDGWRQYIEEDKSASRSRHGQVEVPAKGGNSESRPADEGRIHPSRTSSVDTAQTMVPDEADGYDSAGDISIDPEKGQYSHIIKFLPDDPENPQNWPVAKKVFVTFQICLLTASIYIGSAIYTAGLTDVMKVFGVSQVAALLGLTLFVAGYGLGPMIWSPLSEIPQVGRNPVYIGTLFVFFLLQIPTATSSSFGMLLAFRFISGFVGSPVLATGGATLVDIWSPKKRAYPIACWGIAAVAGPTLGPVVGGFAAMAKGWTWPIWELMWLSGLVFILLFFCLPETSSTNILYRRAKRLRKITGNEKIKSEPEVMAEDLTGKEIVMMCLVRPFTLNFAEPMVFLLNLYIALIYGLLYIWFESFPIIFTGIYGFSPGMQGLAFLGIMAGAFVAIPPFFWYLHKYLEPQFDENGDIQPEKRLPPAFVGAFAIPLCLFWFGWSARADVHWIVPVIGSAWFSVGSTFLFNSVLNYLPDAYPAYAASVLAGNDLFRSAFGASFPLFANTMYERLGVNWASSLLGFLAIVFIPIPFVLYKVGANLRKNHSTHARKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWT1</accession>
    <name>A0A1B7YWT1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglucanase ii</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164941.1">
        <property type="nucleotide sequence ID" value="XM_018296579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWT1"/>
    <dbReference type="GeneID" id="28860686"/>
    <dbReference type="KEGG" id="chig:CH63R_01604"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01604"/>
    <dbReference type="OrthoDB" id="4850003at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR16424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="194" mass="21915" checksum="4E3F77A02A803707" modified="2016-11-02" version="1">MSYSRRDFRDEYPPRRHHHHTPAYSDYSSRASDYSPTRDLGAVTHTHHATTRRSQDDLYEIERNRPRARDLNRGYEEQRPHPRSRSNHDTKHRHGHESHRDHGRSSKRRSSSSGANLTQAAVAAASAGIIEAGLARHDRDRTARVLTAAAGAGAIDAVAARKHEKPHRQWEHVVGSTVGGLVVNRVAHGSRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YWU7</accession>
    <name>A0A1B7YWU7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165032.1">
        <property type="nucleotide sequence ID" value="XM_018296670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YWU7"/>
    <dbReference type="GeneID" id="28860777"/>
    <dbReference type="KEGG" id="chig:CH63R_01695"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01695"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601991" evidence="7">
        <location>
            <begin position="19"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="140"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="775" mass="82569" checksum="DC74F818BAD397DD" modified="2016-11-02" version="1">MRFSHLLPALALVALGAAQENVEEPTEDVEVEVEAKRFIIEFASGVHAKVKRDELSSEEGITVLKTFESAVFSGASLETDNHNLDTLRVLPDVVGVWPNSKARLIAPVKRQVDVDADAAGAHAVHWATGVDEIHKEGILGEGVKVGIVDSGVWYKHAALGGGFGPGFKVVGGWDFVGDGWQAGTAKKPDADPADEQGHGTHVAGILAGESSSGWTGVAPKASLYAYKVFGPGDGTDQATIIDAFLRAYDDGMDIITASIGARGGFANNAWAVVASRIAAQGVVVTIGAGNSGNGGPYYGGTGSSGENVLSVASAEVKRGGGGNGTAAGGDDVLRPSYFTSWGGLYDLSVKPDITAPGTDVFSTWPGGDDNQFVLLSGTSMATPYIAGVAALYISKHGGRAAHGNDFAKDLSMRVISSGASLPWLLYSGEADPAFRAPSQQVGGGLVDARKVVGYATSLELRRFGLNDTLHFRADQGIAVRNTGKDRVRYSFEVESWAGVEMLRAYDARDPGETPRIRYRPEVVPSNISVSVGLPGGFELGPGEERKAKFVFEIPQGVNQTALPAYGGRVLVKGSNGEVVGVPFQGLAFDLKQQMQNPFHGTYPWLRSSPAYSNKTTFTFDLSTAAQDFPKIFMKIKWGSREVRWDIYESGFDEKRDWEYPPVPGRRGYIGSATSWSGAGSSSTFNPARHNASDLFTLPVTDVARNALTTGGFTTSYWWFGRLADGTLVGPGKYTMRFAVLVPFANPENANSWKGLTTEFTILPKPGNSTITKRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7YXH7</accession>
    <name>A0A1B7YXH7_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH63R_01738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR16558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018165075.1">
        <property type="nucleotide sequence ID" value="XM_018296713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7YXH7"/>
    <dbReference type="GeneID" id="28860820"/>
    <dbReference type="KEGG" id="chig:CH63R_01738"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_01738"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="127"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR16558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="203" mass="22526" checksum="2ED8E3FAFDA2214C" modified="2016-11-02" version="1">MLKTRASTLLPQQKGGHHPTHNNRLASKEKNDVGCAMDTTNSAVCDPGRNVFVSKCTRKLTFSFSSRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNLDKYHPGYFGKVGMRYFHKQQNHFWKPVINLDKLWTLVPAEKREEYLAGKGDKVPVIDLLPFGYSKVLGKGRLPEVPIVVKARWVSKLAEKKITEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWJ5</accession>
    <name>H1UWJ5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_04752</name>
        <name evidence="3" type="ORF">CH63R_00619</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000396">
        <property type="protein sequence ID" value="CCF32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163956.1">
        <property type="nucleotide sequence ID" value="XM_018295594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UWJ5"/>
    <dbReference type="STRING" id="759273.H1UWJ5"/>
    <dbReference type="GeneID" id="28859701"/>
    <dbReference type="KEGG" id="chig:CH63R_00619"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00619"/>
    <dbReference type="eggNOG" id="ENOG502S6WE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120084_0_1_1"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR15439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="187" mass="20358" checksum="971C36FF8D82EC20" modified="2012-03-21" version="1">MIRHTASQSLSKKEQTMNIMSIRGSVSSIFLHGNCILRHSRLSPSRPSASSHCQRVPNSTVRLAAPHHHHIATTSAMADRFKLVYTVPASHLAVTKDAVFKTGAGVYDNGKYVQVAFELIGSGQFMPVAAAGADPHTGAVDNLEKVLEYRVEVLCVGRDVTKAAVDALKSAHPYEVPAYEVYKLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UWW3</accession>
    <name>H1UWW3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_04853</name>
        <name evidence="8" type="ORF">CH63R_07879</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
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                <person name="Will I."/>
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                <person name="Schulze-Lefert P."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Sukno S.A."/>
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                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Zampounis A."/>
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                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="258"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="440"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCF32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR16214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="825" mass="93347" checksum="EF90A318F10932A8" modified="2012-03-21" version="1">MFVLRNVGKLIFGSSNQESLIELPQGQLYLVRPLSPKGYSELIFKDAAARIRRTAQDFQYQLVVQRVYEEGEAELLAEEEGEDAEIDALAAAERDEKTFLLDEALHFRVEIREGTEKVLAWRDLSGDTGDVYEFICDNIVSSGQVAQFERTAKECQYERKYRKPHTTASDFDLKQFEFQDEHPIPPASPIHSPTLVRSIESADGLFVPQSPIGTPTKNQEESLVQTPMKTPSKMPVTPEKRKTASPPKSELAPQALSTYATEQSELHFFDFPSGAFVQQDASVTATVTEVGKWKYWLQIESKEKIWLGIPIVADINPVFNFEFLSFIFNHFASDGSAYSWLLRFKDQPALERFQDALLRALWEQLNETKWEKIKEKEQEYVTDAFNDLTMEDTPEEEEEEEEEEYEDAEENDKACAQRSEHYDSDEDGDDVETDDEDGIVNSQLAVGYKHDRSFVVRGSKIGVFKHTADNNVEFSTNISKVETPEGVLFSPKKMMLHNEDRNMVLQNERDANKLYRMDLEYGKIVDEWKVHEDIPILNFAPENKFAQMTHEPTFLGISKNALYRVDPRLSGNKLVDSQLKQYVSKNEFSAVATTEKGYIAVASNKGDVRLFDRLGINAKTHIPALGEPIIGLDVSADGHWILATCRTYILLIDAMQKSGKNEGKLGFEKSFAASEKPQPRRLALTPEHVAQFAHETGKPVSFTPARFNTGEGIEETSIITATGPYIVEWTLKKVLRGIKGAYRIKRYAEEVKADDFKFGTDKNVIVALPNEVNMVGRQGLKRPTRESIAGNFAQLSLGRRDSGRISTPKSGRYKLGKEDVVASPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1UYR7</accession>
    <name>H1UYR7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_00918</name>
        <name evidence="3" type="ORF">CH63R_03758</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02000646">
        <property type="protein sequence ID" value="CCF33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159979.1">
        <property type="nucleotide sequence ID" value="XM_018298733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1UYR7"/>
    <dbReference type="STRING" id="759273.H1UYR7"/>
    <dbReference type="GeneID" id="28862840"/>
    <dbReference type="KEGG" id="chig:CH63R_03758"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03758"/>
    <dbReference type="eggNOG" id="ENOG502STSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949990_0_0_1"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011939318" evidence="1">
        <location>
            <begin position="16"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="293" mass="30569" checksum="22D544233A8FEBB1" modified="2012-03-21" version="1">MKYSLAALFAAVASAAVIDTDNIAEAPEAPAAPELPALRARATGCNADNCLRAVRATRYGTATMELRLAECSSFLAVTETPSATTVFVTESSIETLTANVTRTLYQRQAAAEETAAVLSTQTVPVYASACSDAARYSSACSCFGATAVTTTAPAATVTSTVTVVSTTIVAPFVNVTRPALSCSTVWNCGDATIPVCSTESGCVCFRTAEGRDVCAMPNECESGCDSTSDCGNGEVCIKQSCCAGGTCMKVDVCLNEILPKMMFKRRSAAWVKKQARASLNHLSLVPHDVEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>H1UZJ7</accession>
    <name>H1UZJ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_05602</name>
        <name evidence="4" type="ORF">CH63R_02548</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lapalu N."/>
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                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
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                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
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                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
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                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
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                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
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                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
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                <person name="Thon M."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
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                <person name="Takano Y."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">IMI 349063</strain>
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    <sequence length="369" mass="39535" checksum="37616C85634C5FD1" modified="2012-03-21" version="1">MDPSSPAKRRALAPLDANVNAMSPTKLHKHSRVPGSPLKSPIKTPLGLKRPLAAVVFDENAVAKKKQCQEPAITVAAPASVSAIPPTPTPSTPVPAVVSKGTIASTSTSTSAPSPAASAQTEIDTEPDAQEGQSAQRQQQREEQKLVGEQQEQRQPEKMQVTGEQHQQRQTLRNRSASPDTSSSVFDNSAMDTSQENTTMLTEPDAEQTVRALPLPTSRRLLTREEARQKARILKLKLGLANYKLRTGQENVPLDRLEVKPRPGQQQEMTRDRALPRVMVQPPSSRDGPPGKDTEETRNTEHRERGPEPLAGADKAAEQTESGGTVLPRLMTTGTRAAEQVEGEPTSAVSGGIATSLLSLARGSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>H1V1K7</accession>
    <name>H1V1K7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase family 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_06170</name>
        <name evidence="4" type="ORF">CH63R_02066</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001014">
        <property type="protein sequence ID" value="CCF34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018161857.1">
        <property type="nucleotide sequence ID" value="XM_018297041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V1K7"/>
    <dbReference type="STRING" id="759273.H1V1K7"/>
    <dbReference type="GeneID" id="28861148"/>
    <dbReference type="KEGG" id="chig:CH63R_02066"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02066"/>
    <dbReference type="eggNOG" id="ENOG502S1W9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019533_3_1_1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555472" evidence="1">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="284" mass="31097" checksum="2AB7E5AC7B38DF5D" modified="2012-03-21" version="1">MHLKNLIPSLIFLLPAAQAWDSPDYSGFTRLWLDNFAGASGTGVNEGNWNIITNLRVNNEIQDYTTSRSNLQISGGGTVQIVPQRDAASRWTSGRIESKYTFTPAAGRLTFAEGQIRFGDNAVGNKRGIWPAFWILGDSIRRGVSWPRCGELDVLETVNGQLTGYGTAHCDVLPGGACNEPNGIGGAIGIPDQGWHNWRIQWDRRPNNWQAETITWFRDGQLFHQISGARVGSEGIWSTLARAPLFFILNVAVGGNWPGNPDGATIGGWGSMMETAYVAVYQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V3D4</accession>
    <name>H1V3D4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_06670</name>
        <name evidence="7" type="ORF">CH63R_02513</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02001253">
        <property type="protein sequence ID" value="CCF34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13787.1"/>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02001351">
        <property type="protein sequence ID" value="CCF34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156621.1">
        <property type="nucleotide sequence ID" value="XM_018304598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V436"/>
    <dbReference type="GeneID" id="28868705"/>
    <dbReference type="KEGG" id="chig:CH63R_09624"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09624"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08103.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="302" mass="28888" checksum="A6691072CD1BB30E" modified="2012-03-21" version="1">MKIFVLATALTAFSAGAFARRGGDKTSNKAPTSGGGVGGDDNGIGGFLPTGLPEIGSGGGIKGILPTGLLGGNNKGDASPTKAYGGAGGDGFGDVFPTGLLGGGNKGNILPTGLPGGDIGKGVDGILPTGLLGGGNTGNILPTGLPGGEFGSGIDGILPTGLLGGDKDNILPTGLPGGGIGKGVDGILPTGLLGGNKGNILPTGIPVGNGIDDILPTDLLGGNNKGNANPTRAYDDGEKNNAIPTELPGFGKGAGLDDILPTGFPGFGGGNAPSGFQTRVRAKGTRGSHGHGHGSATPTKAY</sequence>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <taxon>Pezizomycotina</taxon>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="protein sequence ID" value="CCF35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="379" mass="41289" checksum="04F0CEC670266301" modified="2012-03-21" version="1">MATQHSSTPTSNTASVASATSSGARPSCTTAVPGQYGSVPIDACNSYYPFDPSFEGNMAFAGIFGLSLVAHVTQAVVHRKRFCWVISMGASWECAAFILRSLGSRNQQEIGYQIGGQLFLLLAPLWINAFAYMLSARLVYFVLTDQKVTGIKASALTKIFVTVDVVCFLVQAAGGAMMSNTDVSPDDPILRTGKHVYMSGCGLQLGFIVIFCGLMGRFYVKMRRAQRFDLDVRRIRAMVWVVYVVLVLIVIRIIFRLIEFGPGADIDNPILTNENYAFGLDALPMVLALVLLNAVHPGIVLRGENSEFPRPSRAEKKQAKLDRNAAKLESKLAKKAAKNEKKAGMEVDDGEYVIMEERSPATDQHDSGDRAGATGRGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1V5Y7</accession>
    <name>H1V5Y7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CH063_07376</name>
        <name evidence="9" type="ORF">CH63R_03684</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02001625">
        <property type="protein sequence ID" value="CCF35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018159905.1">
        <property type="nucleotide sequence ID" value="XM_018298659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V5Y7"/>
    <dbReference type="STRING" id="759273.H1V5Y7"/>
    <dbReference type="GeneID" id="28862766"/>
    <dbReference type="KEGG" id="chig:CH63R_03684"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03684"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_0_1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCF35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OBR11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="536" mass="60118" checksum="BC1917B1320E3723" modified="2012-03-21" version="1">MPSLALGIHGLSLAFHGASILLRDLVLLTTSSVLLALLAVAGYCLLLHPLARVPGPRLAAISNVWYARQARDGRMLQLGKTLHKRYGPVVRVGPNEVWFDSVDAFKHIYRAGSGYDKSDFYLSTALQRPDITYTPLPTFTSPDTLDLLSERNTQRYRLQRRLIGPLYQTAHLKRHEPALDAVLDRVVATLRSLEGAEIDLKEWMHIIAVESLAAVVLTWSPNYLRDRTDHSSSSHGYMGWRRKSVFGLFPLAVKLELLSKAFGRSFANLWGVTYKTPKNFRPFFTGVYRQVSRRVTAALAGKPVPKNDRKDDFLADLIRLHGDRPDFSEAYLRRMAITNFGAGHETMCSALTSVMAMIGSHPEVQRRAADEVRSATEDPKVYDNAVRLDYTQAAIKEAQRLYPVLGMSLPRTVPAEGLAVHGRVFPPGTTVGCNPVSLHRNAAIFGEDAEEFSPDRWLDGKRDVKSMERFNLTWGGGGRMCPGRHLAELVVYKTIPALLEHFDVEVVMPLEEDIQYYFMAMLTGVKARFVARKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>H1V620</accession>
    <name>H1V620_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_07403</name>
        <name evidence="19" type="ORF">CH63R_05387</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
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        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
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    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>H1V6J0</accession>
    <name>H1V6J0_COLHI</name>
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        <name evidence="2" type="ORF">CH63R_06211</name>
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    <organism evidence="1 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
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                <person name="van Themaat E.V.L."/>
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                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Heiman D."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
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                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
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                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
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            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="MacDonald P.J.P."/>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
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                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
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        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EC" id="1.17.99.9"/>
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        <cofactor evidence="1">
            <name>heme b</name>
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        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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    <dbReference type="STRING" id="759273.H1V8F7"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
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        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX15/CtaA_fam"/>
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    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="99"/>
            <end position="119"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="CCF36510.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8S9</accession>
    <name>H1V8S9_COLHI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">CH63R_09146</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02002068">
        <property type="protein sequence ID" value="CCF36632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156143.1">
        <property type="nucleotide sequence ID" value="XM_018304120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1V8S9"/>
    <dbReference type="GeneID" id="28868227"/>
    <dbReference type="KEGG" id="chig:CH63R_09146"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09146"/>
    <dbReference type="eggNOG" id="ENOG502RJJB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127830_0_0_1"/>
    <dbReference type="OrthoDB" id="3938544at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF36632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="139" mass="16054" checksum="05CBFB78D110444B" modified="2012-03-21" version="1">MSDEDGGLFSIAIDDSDDEGLISEEAAKAKERPRDWQSEEEFQELRATYRVNVQDGDIWQKIELPLAAVVQKTSKPALQELLHAVEELYFLRRFEEAAGFARRVLDGSDAALDRDTRQLLGRYEEKCRGRMEEMRDDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>H1V8W2</accession>
    <name>H1V8W2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CH063_08183</name>
        <name evidence="13" type="ORF">CH63R_09249</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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            <strain evidence="14">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">IMI 349063</strain>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1VAV5</accession>
    <name>H1VAV5_COLHI</name>
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        <name evidence="7" type="ORF">CH63R_02625</name>
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    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">IMI 349063</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02002429">
        <property type="protein sequence ID" value="CCF37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162416.1">
        <property type="nucleotide sequence ID" value="XM_018297600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VAV5"/>
    <dbReference type="STRING" id="759273.H1VAV5"/>
    <dbReference type="GeneID" id="28861707"/>
    <dbReference type="KEGG" id="chig:CH63R_02625"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02625"/>
    <dbReference type="eggNOG" id="ENOG502R82D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041583_1_0_1"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="298" mass="33338" checksum="2202D5C877690128" modified="2012-03-21" version="1">MGRNKPAGRLLSSGRPPTLKKAKSISRKETRTLINTHHTLQKKRQQALARNDQREAATIAEEISALGGLEGYQRASLQGQRVDRGGDSSRVLLDWFRSANIQPSDFTGNLTGKSDTHRRLRMLEVGALSTGNACSKSGFFDMELIDLNSQQAGILQQDFMERPLPKDDSEKFDIISLSLVLNYVPDHSLRGQMLLRTLSFLRQSEDDLSESARALFPSLFIVLPRSCVSNSRYFSQDRLVELMTLLGYVQLEGKVTNKLAYSFWKRLNAPCSPLPAVAKKELNPGPNRNNFTITLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBP1</accession>
    <name>H1VBP1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_08926</name>
        <name evidence="14" type="ORF">CH63R_08738</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002560">
        <property type="protein sequence ID" value="CCF37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000006">
        <property type="protein sequence ID" value="OBR07217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018155735.1">
        <property type="nucleotide sequence ID" value="XM_018303712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBP1"/>
    <dbReference type="STRING" id="759273.H1VBP1"/>
    <dbReference type="GeneID" id="28867819"/>
    <dbReference type="KEGG" id="chig:CH63R_08738"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08738"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_2_1"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR07217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="162" mass="16547" checksum="3F5E536BBB86F1F0" modified="2012-03-21" version="1">MPSELCPVYAPFFGAMGCTVAIVFTCMGASYGTAKSGVGISAMGVLRPDLIVKNIVPVIMAGIIAIYGLVVSVLISDGLAQEMSLYTGFIQFGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLMNSKATQDVVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBU6</accession>
    <name>H1VBU6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CHD5 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Protein GET1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="12" type="ORF">CH063_08969</name>
        <name evidence="13" type="ORF">CH63R_10388</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002590">
        <property type="protein sequence ID" value="CCF37699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154786.1">
        <property type="nucleotide sequence ID" value="XM_018305362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VBU6"/>
    <dbReference type="STRING" id="759273.H1VBU6"/>
    <dbReference type="GeneID" id="28869469"/>
    <dbReference type="KEGG" id="chig:CH63R_10388"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10388"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_1_0_1"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003555136" evidence="11">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCF37699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR06268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="217" mass="24321" checksum="CE1DAE0858967B9C" modified="2012-03-21" version="1">MPSLLVVIFVLEVFSHLVNTIGAATINNLLWTLLNYLPISTSKAAKQHRQLQIEFLKTRKELNATSSQDEFAKWAKLRRTHDKQLEQLEKSKQTQEAARSKFDTYLTGFRWLLTKAPQYGLPFWYSKEPMFWLPYGWFPYYAEWILSFPKAPIGSVSIASWQLACSGMVTLVVEMVVSVVGLALAAKQSKANPAKVPAGAGKAKTVAGLGEKGKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>H1VBX7</accession>
    <name>H1VBX7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_08987</name>
        <name evidence="4" type="ORF">CH63R_11254</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
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    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
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    </reference>
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            <end position="57"/>
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<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VD31</accession>
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        <name evidence="5" type="ORF">CH063_01846</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02002824">
        <property type="protein sequence ID" value="CCF38134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="OBR14520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163037.1">
        <property type="nucleotide sequence ID" value="XM_018298221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VD31"/>
    <dbReference type="GeneID" id="28862328"/>
    <dbReference type="KEGG" id="chig:CH63R_03246"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03246"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NmrA-like"/>
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        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
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    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF38134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OBR14520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="314" mass="34833" checksum="38634E5BA92ABAB3" modified="2012-03-21" version="1">MSSVVAVAGGTGDLGRTFVEAIVADGKWTVVVLARNADEQKEKEIEARILPVDYDDVDNLVKVLEENKVHTVISTLNIRASVKPELNLIAAADRAQSTKRYVPTIWGPKIPREIAAQRPLTQTKIDVTDALEKTTTLEHTSWYIGLFADYYVSPPLKSLVKILPIVVDVANNAAGIPASGNDPVAFTYTIDLAKFVVASLSLPKWRKESYLVNDRLTWNEVVQIAESVKGVKFNVAYDSLETLKAGKITELPGHVVSYPFWPKEQLQGTFSQFGLMFDDGLFDIKPEHPITEDLPDIKLRSFKELLEEAWGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>H1VF38</accession>
    <name>H1VF38_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular serine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_09827</name>
        <name evidence="3" type="ORF">CH63R_13879</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003182">
        <property type="protein sequence ID" value="CCF38841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151171.1">
        <property type="nucleotide sequence ID" value="XM_018308853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VF38"/>
    <dbReference type="STRING" id="759273.H1VF38"/>
    <dbReference type="GeneID" id="28872960"/>
    <dbReference type="KEGG" id="chig:CH63R_13879"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13879"/>
    <dbReference type="eggNOG" id="ENOG502T6RB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053381_3_2_1"/>
    <dbReference type="OrthoDB" id="5421909at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497666" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF38841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="192" mass="20102" checksum="43BC979AD5FEAA54" modified="2012-03-21" version="1">MKFGTLAVYLSAMVGASVAATINERQAPPAPPGPAPPNPKVIPVLVGSPTREKSLLFYPEIVKANPGDIVQFQFWPNNHSVTQAANPQAPCVPLQDQNPNAVHSGFIPGVTDGSPIGTFNVQVENTEPMLMYCAQGMHCQLGMVMIINPKADADVQAYRQAAGQSQTNVPAKNVAGGSAGRIPSNLAVPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGN7</accession>
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        <submittedName>
            <fullName evidence="6">WD repeat domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_02115</name>
        <name evidence="7" type="ORF">CH63R_11727</name>
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    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003468">
        <property type="protein sequence ID" value="CCF39390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153542.1">
        <property type="nucleotide sequence ID" value="XM_018306701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGN7"/>
    <dbReference type="STRING" id="759273.H1VGN7"/>
    <dbReference type="GeneID" id="28870808"/>
    <dbReference type="KEGG" id="chig:CH63R_11727"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11727"/>
    <dbReference type="eggNOG" id="KOG0270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023867_0_1_1"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001345">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF39390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR05024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="536" mass="59352" checksum="E07A10F4096B9D4F" modified="2012-03-21" version="1">MSMITTSTWVPRGFAAPFPSKYTFDESEYERIAELAKLQLDDAEEDLKEAQDAEDGVAASATNGTEESKTEKVNLDDEDLKEYDLEHYDDSDEDDEEKVGQGEGMAMFGNIKSLAYYESNKEDPYITLHGNGGPDDDEDEDREDLQILATDNLLLAAKVEDEMAHLEVYVYEDSADNLYVHHDIMLPAIPLCVEWLDIPVQKAGVDQDSRANFVAIGTMDPDIEVWDLDTIDSLYPNAILGQAGEGAADKKKKKKKARKANDEYHVDAVLALAANRKHRNLLASASADKTVKLWDLHTAKCAKSYSYHTDKVCSLAWHSIESTVLLSGSYDRTVVAADMRAPEAKAPRWGVESDVENIRWDPHDPNYFYVSTENGIIHFHDVRNAPATPEATKAVWTLQAHDESVSSFDINPVVPGFMATGSTDKTVKLWNIQASGPSMVVSRNLDVGKVFSTQFAPDPEVAFRLAVAGSRGTMHVWDTSTNAGVRHAFAERVPQRPEGVEEDRLVGVLDDDSSSSEDEDEGEEGEKDGDDSMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VGQ6</accession>
    <name>H1VGQ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_10248</name>
        <name evidence="3" type="ORF">CH63R_03361</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02003480">
        <property type="protein sequence ID" value="CCF39409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163152.1">
        <property type="nucleotide sequence ID" value="XM_018298336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VGQ6"/>
    <dbReference type="STRING" id="759273.H1VGQ6"/>
    <dbReference type="GeneID" id="28862443"/>
    <dbReference type="KEGG" id="chig:CH63R_03361"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03361"/>
    <dbReference type="eggNOG" id="ENOG502S0TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047034_1_0_1"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF39409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR14635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="287" mass="32193" checksum="D96821F3ADB247D9" modified="2012-03-21" version="1">MDLLICGTCGVQYDSHAVKSCKICDDPRQYVAEDGQWFTTLRELQDSKKYRNVFTKDKYNSGVVAVRTEPPVAIGQRAFLLRSPAGNLLWDCITYIDDDTVRRVNELGGIAAIVISHPHYFSTALHWAEAFGCKVYVSAEDGEWLTRRGDAHVLWEGRDMEFLGGQFLAVKVAGHFPGSSVLLWRSERKLFVADSVMVVPSGVYHVDRPPGTASFAFMWSYPNMIPLSPEDVYDIWKAVSKLDFEDAHSAFPGRDARGDAKRRLLDSAQIFVKSVGYIDHPIHGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VII4</accession>
    <name>H1VII4_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C6 finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH063_02263</name>
        <name evidence="6" type="ORF">CH63R_04739</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
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                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
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                <person name="Rech G."/>
                <person name="Reinhardt R."/>
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                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
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                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
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            <begin position="89"/>
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            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
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    <gene>
        <name evidence="1" type="ORF">CH063_11191</name>
        <name evidence="2" type="ORF">CH63R_07200</name>
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CCF40696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_018302175.1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCF40696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="260" mass="27440" checksum="0C74E6A3C1F302FB" modified="2012-03-21" version="1">MAPILIVGATRGLGASLTKQYAADPANTVYGTTRLKEGPEGFPENVKWLTGVDLTNSKVGETIASQLSSGGSKPLSTVIITAGYFATEDFSADKGPDWAEEQRMYTTSSIAPVFVVHALAHAGLLQGGSRVVLVSSESGSITLRHEKEGGGNYAHHASKAALNMVGKLLSLDLKEKGVVVSIVHPGFMRTEMTKGVGFDKYWDDGGAVTPDEAAESLIKWASQLDMSKTGEYWAPRGPGDIGTAEPVLGKGLSTPLHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>H1VLX1</accession>
    <name>H1VLX1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CH063_02543</name>
        <name evidence="10" type="ORF">CH63R_06992</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02004567">
        <property type="protein sequence ID" value="CCF41224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018156745.1">
        <property type="nucleotide sequence ID" value="XM_018301967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VLX1"/>
    <dbReference type="GeneID" id="28866074"/>
    <dbReference type="KEGG" id="chig:CH63R_06992"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06992"/>
    <dbReference type="eggNOG" id="KOG2615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCF41224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="602" mass="64935" checksum="851E852BA4928B3F" modified="2012-03-21" version="1">MARNNAVRAAATSRTASSGSFHAGAPIPTLGAIESSRRILVRRQSTHRYHTFPTPPPKTPREQSSAELFPHSDDGSNASDDGHGQTPLPVKQLALLAFLSLSEQTALNSIGPYLPQMVESFSDIPDSQTGLYVGILASAFALAQLSTNLLWGYLSDVVGRKPTMVMGTFMLAGCFVAFGFCRTYWQIVVVHVAMGMLNGNAAVVPTVLGEVTDRSNQSRAFTWLPVIYSLGGITGPALGGLLVGTLGKRYPYLAPNLLSAALLLISVLVVGIWFEETLESLEPDHAAWIPNWARNAWSWVQRRVAEPRRDSWATRWPRRGSQIVTSTSDDEDEEEDDDDVTEEQRLLRPGSENGSDVDDDAKSPSDLATWRQLLNRNTILVLLTYLVFQLSNISYNSLYPIFADANPPTGRGLPPSKIGISLSLAGVATIVFQAFLFRPLKVRLGNLGTYRVALLGLAISMALMPWIGYLDDEPLFGVGTGSIWLYIELGIILVIKNICAVGGLSSVMLLITNCAPNHATLGTLNGIAQTLSAAGRSFGPFVSGALFTLSTRVHPKGEALAWGIFGGIALLGWLGSLAIRNRGLESDDWVGEEDGTDGEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>H1VN94</accession>
    <name>H1VN94_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_11900</name>
        <name evidence="3" type="ORF">CH63R_12581</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
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    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">IMI 349063</strain>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">IMI 349063</strain>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IMI 349063</strain>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
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    <dbReference type="EMBL" id="CACQ02005026">
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        <property type="molecule type" value="Genomic_DNA"/>
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            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
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                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005123">
        <property type="protein sequence ID" value="CCF42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="OBR06982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VPB5"/>
    <dbReference type="GeneID" id="28867584"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_08503"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="140" mass="15663" checksum="7C71C1E972A71B5A" modified="2012-03-21" version="1">MGAKVPRNFRLLEELEKGEKGLGAEACSYGLNDAEDLLMSDWNGTILGPPHSVHENRIYSLKMHCGPNYPDEPPTIQFISQVNLPCVNSRNGVVDPKQLPCLANWKRDNTMETVLIELRRYMAAPANKKIPQPPEGSSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>H1VPL2</accession>
    <name>H1VPL2_COLHI</name>
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        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CH063_12240</name>
        <name evidence="15" type="ORF">CH63R_09869</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="CCF42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_018154267.1">
        <property type="nucleotide sequence ID" value="XM_018304843.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VPL2"/>
    <dbReference type="STRING" id="759273.H1VPL2"/>
    <dbReference type="GeneID" id="28868950"/>
    <dbReference type="KEGG" id="chig:CH63R_09869"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09869"/>
    <dbReference type="eggNOG" id="KOG3366">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_080463_0_0_1"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005743">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
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    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
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    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCF42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OBR05749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="173" mass="19359" checksum="34C2A6B767D3F380" modified="2012-03-21" version="1">MATRSAALKLDWAKVTTSLGLRGQTAASLQAFKQRNEIARRRVQQLSELPTTVDFAHYRSVLKNQAVVDEIEKRFTAFKPATYDVSRQIKAIEAFEVEAVKNAEATKQKVDLELKDLEKTLTNIESARPFEDLTVDDVAAAEPSIDEKTSQLVSKGRWSVPGYKEKFGDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>H1VQQ3</accession>
    <name>H1VQQ3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_12519</name>
        <name evidence="4" type="ORF">CH63R_07665</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02005475">
        <property type="protein sequence ID" value="CCF42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000005">
        <property type="protein sequence ID" value="OBR08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018157418.1">
        <property type="nucleotide sequence ID" value="XM_018302640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VQQ3"/>
    <dbReference type="STRING" id="759273.H1VQQ3"/>
    <dbReference type="GeneID" id="28866747"/>
    <dbReference type="KEGG" id="chig:CH63R_07665"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_07665"/>
    <dbReference type="eggNOG" id="ENOG502R6VN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042442_1_0_1"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="347"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="427" mass="48109" checksum="6F3974812F0FD704" modified="2012-03-21" version="1">MADKPNHTAITQPTTPVVFDSIRARQLPFNISKMQSSPSAPVSQTMDPKHNMTPPQATTMARDTKNVFDISNLMSPPEPVPYDNFNQNQQHSMSMFPASHLAQEATKPSMPMSPPVSPYITEAGNVPTSGTSAKDPILYPRDDNASSPIQPPLFPSTESIEHRRIVEEHIVARPPGLFREGSPPQREDYELALQLKSQVMRLFANKRKSWYEKEREQVRADRKLNHARWNSVVRYQTIAPAKSAPTKATKLVPAKSKAITSANPKPDRIVKPQAPRPVRSSPPTRHIRRVSATPDPARRVVAPNREDRDFAALPDYCPPLSSLPDKPNCLKVDWKGAPIDLSDDTNVHLLHPDEVSLAANLRLDCATYLTSKRRIFVRRLECARVGKEFRKTDAQQACKIDVNKASKLWTAFDKVNWLELKWMSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1VSA9</accession>
    <name>H1VSA9_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_02998</name>
        <name evidence="8" type="ORF">CH63R_13875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">IMI 349063</strain>
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        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
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    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
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            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
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        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
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                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
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            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
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    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
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                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
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        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="759273.H1VSE6"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CH63R_06428"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497729" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="292" mass="30960" checksum="9A8EBF23C50C986C" modified="2012-03-21" version="1">MHTLNLLLAVLPLLPQAQAALQRVVNFGFNPTGLTMEISVPPNPAPLPAIILALHGCGGSGQAYARQADYVSLSDSKRTFLVIYPSSTRDFNCWDVATVATLTRDGGGDSTGLASMVQYAIARYGADPKRVFVTGSSSGCMMTNVLAATYPDLFAAGSCYSGVAAGCLAGSPGSSPISADPRCANGQIVKTGEQWATQVRAMYQGYSGSYPRIQTFHGTADTLVKHPNLAEQLKEWSAIHGVTFARNNTNNPTVGYTQMVYGDGTKLVGYSAQGIGHTVPVQREQDLKWFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>H1VT59</accession>
    <name>H1VT59_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH063_13129</name>
        <name evidence="8" type="ORF">CH63R_10351</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02006085">
        <property type="protein sequence ID" value="CCF43417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR06231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154749.1">
        <property type="nucleotide sequence ID" value="XM_018305325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VT59"/>
    <dbReference type="STRING" id="759273.H1VT59"/>
    <dbReference type="GeneID" id="28869432"/>
    <dbReference type="KEGG" id="chig:CH63R_10351"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_10351"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="201"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCF43417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OBR06231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="336" mass="36691" checksum="F1C9B3B6DA63FD42" modified="2012-03-21" version="1">MPHKARVLLVGGGGIGTIAALNLEHGGLAEVTAVLRSNFDIVSRKGFSISSCDHGTLENWRPARVLNSVPNTSDASPEERYDYLVCCTKNVPDAGSPLPDIVAPAVTPGHTVIVLIQNGLNIQRPFFDRFPSNVVLSGVSRVDAHEVCPGVVEQKQHDLLHIGAFRNPRLDDDEEQQARAARRFVALYAAGGAATCLHEPDVDLDRWRKLVYNASFNPICALTGLNASELQMTGKTMDTMVIPAMREVLAVATAAGHEIPGDIVEKTIQLNPVEENIKPSMQVDFEKGNLIEHENILGEVVREAQRHSVATPILTVLYELCCAHQWRFKKDRGLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1VV15</accession>
    <name>H1VV15_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CH063_13592</name>
        <name evidence="12" type="ORF">CH63R_04636</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006598">
        <property type="protein sequence ID" value="CCF44074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160857.1">
        <property type="nucleotide sequence ID" value="XM_018299611.1"/>
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    <dbReference type="AlphaFoldDB" id="H1VV15"/>
    <dbReference type="STRING" id="759273.H1VV15"/>
    <dbReference type="GeneID" id="28863718"/>
    <dbReference type="KEGG" id="chig:CH63R_04636"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04636"/>
    <dbReference type="eggNOG" id="ENOG502SC5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050914_1_1_1"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
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    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCF44074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OBR12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="235" mass="25606" checksum="75F4739A1DE08B26" modified="2012-03-21" version="1">MMPAGVSSQPQQQQQPPPPPPPPQPQQPQQQQHIAPPPTTAGPSTAPPIHSPPSGMALDETAEGRKAKRELSQSKRAAQNRAAQRAFRQRKEGYIKKLEQQVRDYMEMEQQYKATQSENYALREYVIHLQSRLLDVQGEVPQPPPNVNLQHPPMPPPAAVPTSGPEVAPSNGGAGPLEAVAQAVAGLQAQEQLAERQQFTSKGFQAEQVKDEARRESEEIDPQLPDGLPAPTASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>H1VVL5</accession>
    <name>H1VVL5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2 super family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH063_03288</name>
        <name evidence="14" type="ORF">CH63R_02666</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02006767">
        <property type="protein sequence ID" value="CCF44275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162457.1">
        <property type="nucleotide sequence ID" value="XM_018297641.1"/>
    </dbReference>
    <dbReference type="STRING" id="759273.H1VVL5"/>
    <dbReference type="GeneID" id="28861748"/>
    <dbReference type="KEGG" id="chig:CH63R_02666"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02666"/>
    <dbReference type="eggNOG" id="KOG1015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001161_0_0_1"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18007">
        <property type="entry name" value="DEXHc_ATRX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1277"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="608"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1595"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="837"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1611"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCF44275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OBR13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1814" mass="203463" checksum="E16896120654DEED" modified="2012-03-21" version="1">MAGQEDDPYEWDVEQVVHELCTEEKRPWHPKLITKRPDPAALSKALVENDIDGETLLTYQDVMPSLDGLFRDLGLIKTTHKMTFAKAVNYLKSKSRGYREFKADLVRPDVETPTNSQEVRVDGDHELAVPAQITASESQKKPPSVQDVEIQANQDHSSPATTLLQSQALPTNEPDTEVLNQINHLRTAQIDGTDQETSEPPQKKRRMAPSLVSNDVLGVGNAPIRTAADNLAERLYGSKNAQPPDSPTTNSFGDKEHDASTTERVTKAYFGRKGLITDGRIPKSSLVRNARDEVGGGGDDTFNLVTKGSFPNGRRRQVGRAIRRLFRANSQSLAMMQTGQSPYVEPEEEDKILPLFGDSDGEDGYDTETREAMENEEEELRREMELKSRYLTPDDVSRVLQEVIQQIEDSWDDRKLPKKQRKANEIWNKARRRGLVRQIAAATSTLGKLTTRIEKLCQEIRKDQWPDEEQLRGQARCLECSVEDRKAERWLLDVLRGHEPPRLETMPKPRLIIKKRDILSDEDGELITSDDDDDELIVHDKMDFAYSPALVASRHASPMKLDSFGELPALGSHGSEVPKHESPAENLVDIQSDTNIIDLTACDSEPLFEKNTGEETGSRVICLDTPEKPRPNPTLMPPSLPDSDIEEQPSLTREELETPYNQPERIGAILPKMWKAALDNSRFLICIIWRLDAQRREAFFRTITSMAPADIWTDFVMMALEDTGNEEQESTREMGTVIARLFRTYVFGKMVSPSSVAKPMRERKARTIRSKVERFEGFCDFVKEHVVPHFPEAIQITGSDSGTPRRNRRRSLDSLIGYSDDEILNSPSKKRKRVVIIDQAAKDIRESDRQRKEEQEKRRAELRKKLAASDTISSDKSRLIINETKEDNQGLIYVNEDIGKRIKNHQIDGVRFMWNQIVYHSKVRQGCLLAHTMGLGKTMQVITLLVAIAESAQSQDASIRSQIPEDLRQSKTLVLCPSVLVDNWMDELLMWAPDGLLGRLFKLEAITRAPERGPMIRTWDEEGGVLIVGYDMFKRLIDPPTNEFPPPADAKSVKDILTQSPNLVIADEAHKLKNPESKLSMAAAQFRTQSRIALTGSPLANSVLEFFYMIDWVAPGYLGPLSEFKACYAEPIQAGLYEDSSRSAYRKAKKALAVLEATVAPKTNRATIQSILQDGLPPKKEFVLTVPLTSLQAKLYDSFLESLRKEELGLGGKILGAVSNFCLIANHPKAFETRLREECKLLQKRDKANLTLTSQIISEGLKITKLQKDMSSHVLSWKVQLLVAILDQSEKVGDKVLVFTQSIPTMDYLDSLFRQQRRKIARLDGNTPISIRQQNIKDFNNGDSHLYLISTAAGGTGLNIYGANRVVIFDFKYNPIHEQQAIGRAYRIGQQKQVYVYTFISGGTYEQAMHNKAVFKTQLASRVVDNENPKRWSKKENEYLKNREEPPQQDLSRFAGLDTVLDSLLMHPDLSQGIRSIIMTDTFKEEDTNEILTQEDLKDVKEQVYLNSIRNTDPAKFRQLELERLGRLHAAPSVVGIAAVPQPPYRPLVMPVSGVETPIPLPVLPSTAVSNPPYIPGQSASAAVKIVTAAQTPLTTVTPPPLEAAGLPNQADENTGTKQQASSQAGLNVASSVENADKKATETRSVPPMPMAGANTFFRNQQEPVTPPPAEKFLPSSTRKEAKTKSSIINWPDQFEQKVLESVDKVTDPELLDAIGANKNDLAKRIASSTWHIRSEMNEGFLSDNSHMKRLCSLMENPRFAAAVLTGHLPPAQIAHASTEAGLNNIVDELIKLDDKTFQEKFGLRRDSTKQPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1VXG5</accession>
    <name>H1VXG5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH063_03454</name>
        <name evidence="3" type="ORF">CH63R_13697</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02007290">
        <property type="protein sequence ID" value="CCF44927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150989.1">
        <property type="nucleotide sequence ID" value="XM_018308671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VXG5"/>
    <dbReference type="GeneID" id="28872778"/>
    <dbReference type="KEGG" id="chig:CH63R_13697"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13697"/>
    <dbReference type="eggNOG" id="ENOG502T7AK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177944_0_0_1"/>
    <dbReference type="OrthoDB" id="5425892at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCF44927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="78" mass="8816" checksum="5F92ADF68D848AF3" modified="2012-03-21" version="1">MSSAQQTPRTAQAASPETSNYTTSPHATAVPPQIVERTNSWKPSFERRQSWNKEDQKRELQMSHIDDVKTGPGFTERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>H1VYS5</accession>
    <name>H1VYS5_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CH063_03587</name>
        <name evidence="19" type="ORF">CH63R_00853</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="CACQ02007701">
        <property type="protein sequence ID" value="CCF45387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000001">
        <property type="protein sequence ID" value="OBR15673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018164190.1">
        <property type="nucleotide sequence ID" value="XM_018295828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1VYS5"/>
    <dbReference type="STRING" id="759273.H1VYS5"/>
    <dbReference type="GeneID" id="28859935"/>
    <dbReference type="KEGG" id="chig:CH63R_00853"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_00853"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010395792" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="294"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCF45387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OBR15673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="505" mass="55148" checksum="E1B61E310AF181C0" modified="2012-03-21" version="1">MFCKRVALGLLAAAAAVSASDVTQLKKDDFNDFIKSNDLVLAEFFAPWCGHCKALAPEYEEAATSLKEKNIKLVKVDCTEEADLCQEYGVEGYPTLKVFRGPESVSPYSGQRKAGAITSYMVKQSLPAVSILSKDNLEEFKTADKVVLVAYIDASDKSSNETFTKVAEKLRDTYLFGGVNDAAVAEAEGVKAPAIVLYKSFDEGKATFSEKFDAEAIETFAQTAATPLIGEVGPETYSGYMSAGIPLAYIFAETPEEREELGAALKPIAEKHRGKINFATIDAKAFGAHAGNLNLATDKFPSFAIQETVKNQKFPYDQDKKITHDDIAKFVEDFSSGKIEPSIKSEPIPESNDGPVSVVVAKNYEQIVLDDKKDVLIEFYAPWCGHCKALAPKYEELGELYAKSEFKDKVVIAKVDATLNDVPDEIQGFPTIKLYPAGGKDAPVTYSGSRSIEDLIEFVKENGKYKAVVSVKEEGAEESQAAPAATEEEKTKETKEAKEDEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>H1W3J2</accession>
    <name>H1W3J2_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nacht and wd40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH063_15597</name>
        <name evidence="4" type="ORF">CH63R_04745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CACQ02009321">
        <property type="protein sequence ID" value="CCF47055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000003">
        <property type="protein sequence ID" value="OBR12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018160966.1">
        <property type="nucleotide sequence ID" value="XM_018299720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W3J2"/>
    <dbReference type="STRING" id="759273.H1W3J2"/>
    <dbReference type="GeneID" id="28863827"/>
    <dbReference type="KEGG" id="chig:CH63R_04745"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_04745"/>
    <dbReference type="eggNOG" id="ENOG502S0IF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028035_2_0_1"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCF47055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OBR12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="342" mass="36264" checksum="00ECF9E2CEE2EE5A" modified="2012-03-21" version="1">MSKRTTFTTISPLPAGITREAVLDFLHNHVEMIDLNPLIKERHRIPAPSHAPPEEHACAWYSLTDEISYLPGGLVTGNVSYTCCFHDLPTGMQTHCYAPMGLEIRDKWTVAGCLPGEPVEPVELGIGAPVLGLYIREDVDMRCNVFTTSFVKKTLKKSHGLLVERLRSKVQQASSSPSVAAADQRHASQTSLLSGPGTNGASSHMPPHPHPPQTHPGQTHYTNAPADQICLPYRPSHPKSPSTPPGDESQNATYPEPLRFRHAAAPLTSSLCSDAGSQPGGLGGGSGSGSGSGSGSNSNYTHGSQSGFGGIHPCDDTHQRAVAGQQQYSGGTLQGPFVAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>H1W4Q4</accession>
    <name>H1W4Q4_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CH063_04169</name>
        <name evidence="16" type="ORF">CH63R_13631</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="CACQ02009756">
        <property type="protein sequence ID" value="CCF47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000010">
        <property type="protein sequence ID" value="OBR02405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150923.1">
        <property type="nucleotide sequence ID" value="XM_018308605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W4Q4"/>
    <dbReference type="STRING" id="759273.H1W4Q4"/>
    <dbReference type="GeneID" id="28872712"/>
    <dbReference type="KEGG" id="chig:CH63R_13631"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13631"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="reaction ID" value="UER00339"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="P:L-phenylalanine catabolic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Jelly Rolls"/>
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        <property type="entry name" value="HgmA_C"/>
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        <property type="entry name" value="Homogentis_dOase"/>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="RmlC_Cupin_sf"/>
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        <property type="entry name" value="hmgA"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="280"/>
        </location>
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        <location>
            <begin position="282"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004704"/>
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            <dbReference type="ARBA" id="ARBA00007757"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
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        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCF47467.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="OBR02405.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="441" mass="48907" checksum="21B6307252F9C9D3" modified="2012-03-21" version="1">MPVTNFSTEDKYQYLNGFGSFHESEAIKGALPIGANSPQKAPYGLYAEKLSGTAFTAPRHENLQTWLYRIIPSASHTSFEPLKHNKPESGGKLHQIPNQLRWDPFDINHETDWISGLRKVGGAGDPTLKTGLGIFIFAAGRSMDSNVATYSSDGDMLIVLQHGDLNIKTEMGNLLVRPNEIVVIPRGIKYRVDLPSGPVRGYILELYQGHFVLPELGPIGSNCLANPRDFQIPTAAFDEDATGWSIINKFNGDFFIAEQNHTPFDVVAWQGRYYPYKYDLGRFSVIGSISFDHPDPSIYTVLTGPSDHPGTAVADFVIFPPRWLVQEDTFRPPWYHRNTMSEFMGLICGDYDAKTGGGFRPAGASLHNVMSAHGPDASTFERASNAELKPQKIGEGSMAFMFESSLMIGVTDWGLETCQKVQKGYSEDSWTGLVSHFKRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5A7</accession>
    <name>H1W5A7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amid-like mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CH063_04241</name>
        <name evidence="7" type="ORF">CH63R_03325</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CACQ02010000">
        <property type="protein sequence ID" value="CCF47671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018163116.1">
        <property type="nucleotide sequence ID" value="XM_018298300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5A7"/>
    <dbReference type="STRING" id="759273.H1W5A7"/>
    <dbReference type="GeneID" id="28862407"/>
    <dbReference type="KEGG" id="chig:CH63R_03325"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_03325"/>
    <dbReference type="eggNOG" id="KOG1336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_6_2_1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCF47671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="421" mass="45088" checksum="323E336C8C092BD0" modified="2012-03-21" version="1">MAAEPTTPSSQRNIVILGGSYGGVSTAHYLLKHVLPKLPNHDVYQVALVSPSTQALCRPACPRALISDDMFPQDKLFVDILTAFTSYSKTTPFRFVHGTATSVNHVERTVDIALANDHGVETLTYHALVIATGASTPSPLLGLNRDAETLRQSWAEFRKDLPKAKSIVIAGGGPAGVETAGELGEHLNGRAGWASTKLENPKTSITLVTAASQILPALRPSIAQKAEEYLAQVGVTILKGVRVEAVSPALAGVGQVVQNAAITLDSGKTLEADLYIPATGTRPNTDFVDGSLLLPDRRVDTNPSTLRVDKAGARVYAIGDASSFARPAVHNILSAVPVLCFNIRRDLLLTSERPEAAAAEDRLFTEDTRETQLVPIGRSKGVGAAMGYRLPSFGVWMIKGRDYWLWTTGSLWSGSQWAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-03-21" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>H1W5W5</accession>
    <name>H1W5W5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Legume-like lectin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH063_00097</name>
        <name evidence="11" type="ORF">CH63R_02690</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genome sequence of Colletotrichum higginsianum IMI 34906.</title>
            <authorList>
                <person name="Ma L.-J."/>
                <person name="O'Connell R."/>
                <person name="van Themaat E.V.L."/>
                <person name="Stueber K."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Haas B."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Arachchi H.M."/>
                <person name="Berlin A."/>
                <person name="Chapman S.B."/>
                <person name="Gearin G."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Heiman D."/>
                <person name="Howarth C."/>
                <person name="Larimer J."/>
                <person name="Lui A."/>
                <person name="MacDonald P.J.P."/>
                <person name="McCowen C."/>
                <person name="Montmayeur A."/>
                <person name="Murphy C."/>
                <person name="Neiman D."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2012" name="Nat. Genet." volume="44" first="1060" last="1065">
            <title>Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses.</title>
            <authorList>
                <person name="O'Connell R.J."/>
                <person name="Thon M.R."/>
                <person name="Hacquard S."/>
                <person name="Amyotte S.G."/>
                <person name="Kleemann J."/>
                <person name="Torres M.F."/>
                <person name="Damm U."/>
                <person name="Buiate E.A."/>
                <person name="Epstein L."/>
                <person name="Alkan N."/>
                <person name="Altmueller J."/>
                <person name="Alvarado-Balderrama L."/>
                <person name="Bauser C.A."/>
                <person name="Becker C."/>
                <person name="Birren B.W."/>
                <person name="Chen Z."/>
                <person name="Choi J."/>
                <person name="Crouch J.A."/>
                <person name="Duvick J.P."/>
                <person name="Farman M.A."/>
                <person name="Gan P."/>
                <person name="Heiman D."/>
                <person name="Henrissat B."/>
                <person name="Howard R.J."/>
                <person name="Kabbage M."/>
                <person name="Koch C."/>
                <person name="Kracher B."/>
                <person name="Kubo Y."/>
                <person name="Law A.D."/>
                <person name="Lebrun M.-H."/>
                <person name="Lee Y.-H."/>
                <person name="Miyara I."/>
                <person name="Moore N."/>
                <person name="Neumann U."/>
                <person name="Nordstroem K."/>
                <person name="Panaccione D.G."/>
                <person name="Panstruga R."/>
                <person name="Place M."/>
                <person name="Proctor R.H."/>
                <person name="Prusky D."/>
                <person name="Rech G."/>
                <person name="Reinhardt R."/>
                <person name="Rollins J.A."/>
                <person name="Rounsley S."/>
                <person name="Schardl C.L."/>
                <person name="Schwartz D.C."/>
                <person name="Shenoy N."/>
                <person name="Shirasu K."/>
                <person name="Sikhakolli U.R."/>
                <person name="Stueber K."/>
                <person name="Sukno S.A."/>
                <person name="Sweigard J.A."/>
                <person name="Takano Y."/>
                <person name="Takahara H."/>
                <person name="Trail F."/>
                <person name="van der Does H.C."/>
                <person name="Voll L.M."/>
                <person name="Will I."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Zhang J."/>
                <person name="Zhou S."/>
                <person name="Dickman M.B."/>
                <person name="Schulze-Lefert P."/>
                <person name="Ver Loren van Themaat E."/>
                <person name="Ma L.-J."/>
                <person name="Vaillancourt L.J."/>
            </authorList>
            <dbReference type="PubMed" id="22885923"/>
            <dbReference type="DOI" id="10.1038/ng.2372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-02" db="EMBL/GenBank/DDBJ databases">
            <title>Resequencing and annotation of the Colletotrichum higginsianum genome.</title>
            <authorList>
                <person name="O'Connell R."/>
                <person name="Zambounis A."/>
                <person name="Thon M."/>
                <person name="Dallery J.-F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CACQ02010235">
        <property type="protein sequence ID" value="CCF47879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LTAN01000002">
        <property type="protein sequence ID" value="OBR13964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018162481.1">
        <property type="nucleotide sequence ID" value="XM_018297665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="H1W5W5"/>
    <dbReference type="STRING" id="759273.H1W5W5"/>
    <dbReference type="GeneID" id="28861772"/>
    <dbReference type="KEGG" id="chig:CH63R_02690"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_02690"/>
    <dbReference type="eggNOG" id="KOG3839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041093_1_1_1"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000007174">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010497809" evidence="8">
        <location>
            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCF47879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OBR13964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="321" mass="35675" checksum="9C4F4C5E8F28F155" modified="2012-03-21" version="1">MWFRQSLSALWLAAMAMGTAKADDGEVKSIALRTHSLNQPYLDSDMASRWYDFGGDTIVRTDSYIRLTSDRPSQTGWLFSRVPLTATNWEIEVEFKIHGKNQLYGDGFAMWVTKSRAQAGPVFGSPDNFEGLGIFFDTYKNNRPGTVFPYVMAMYGDGKTPYDKDNDGKNTELAGCSARGIRHASVPTKAKVTYFQDKLLKLELQYKSEGEWTLCFETSEPPAIPQIAYLGFSAETGELSDNHDIISVQAKNLYTTQAGKSSSKTTPGSGKGKKGSSITKESGGGSWTWTFFKIFLFFGVLGGGYVGYTAWRAKSDKRHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQB0</accession>
    <name>A0A1B7XQB0_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-ketoacyl synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CH63R_14522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150468.1">
        <property type="nucleotide sequence ID" value="XM_018309496.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28873603"/>
    <dbReference type="KEGG" id="chig:CH63R_14522"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14522"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="9"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2669"/>
            <end position="2746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1046"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1213"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1774"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1078"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OBR01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="2760" mass="296932" checksum="1902F5D26DD91F08" modified="2016-11-02" version="1">MGSTVPGLDEDIAIIGMACRFPGDATSPSRLWELLMDGRSAWSEIPASRWNRDAHYHPSQERAGSNTVRGGHFLRDGEQNGKQFDAAFFNITRKETETMDLQQRIVLENVYEAMESAGLRLEDVKGSNTSVFAGVFTDDVRSILQEDPDLSVKYKPIGTSAAILAARVSWFYDLRGSSFTLDTACSSSIVALHTGAQDLRAGLSDMSIITGVNIIESPEFMFRASGLGMVSPDGKCFSLDARANGYGRGEGVGTLILKPVRAAIRDGNVIRAVVRGTGVNSDGRGTGGITLPNKEAQVRLIRDVYARNNLDPDHTGFLEGHFTGTPAGDPIEASAIAAVFQRGGPPRGAAAAAAAADRPPLYVGAVKANIGHVEAASGMAQVIKTVLVLENGIIPPNTNFEKINPRIPIDRWGLKLPLVPTPFEAGPSGVRRASINSFGFGGTNAHVVLDDAKSYLDRLGLGGERGSLLHATKPGTGAPLASPPGEDKSPQQQKQQAVAGHKIFFFSANDQDGISRVLTSLAEYLQKKQQQQTGENESTSPTDMDDAYLSSLAMTLSERRSRLAWRLAVTADSATSLVAALADPTTITTCAVRPGKASTPAAAFIFTGQGAQWFAMGRELLVFDVFRASVAEADRFIAGTLGSGFSVLEELAQRSAETSRIDEPLYSQTLCTVLQVALVDLLASWNLAPRRVVGHSSGEIGAAYAAGALDRESAWKVAYYRGVVSAKPAADNTRGAMMAVGCTADEAGPLIARVHEELGADGELVIACYNSPRSLTISGDETKVDALMKVASGKGLFARKLRVAKAYHSRHMIPVSDEYRSLMGTLRAGAATAGAGAGAGAGASTATIPAAVLGLGCNPNPNPTQSPSSDDVQVMSSVTGGLMAASDMTDADYWVRNLVSPVRFSQALVALCTSNVAKRQLKVGGGAELPVSHLVEIGPHGALQAAARDAVLSDPNHKALRYVSVLTRGKHACVTTLNAVGALAAAGLPVDLAKVNRYNNNNNNNNNNKAMLVDLPPYPFHHAKETYSWLESRTSRAWRFRKHARHDVLGAPVRDWDPDAPRWRNHLRVSEVPWLRDHKVTDSIVVAGVTYLVMAIEAVRQLYGDRGEAPLGFNLRDVSISRALQVSEGEHTETVFSMKRVAESRQSDSSLWWEWKVTSFSAHDDTWLEHSRGQIAAETEASTATGVVDDGREERAQRRHYSELLSTVTRACAAPQTELLPSKYAELERIGLGFGPLFRNIASMYGYSNSKSGSGSGSGTSSDNKTGGGQSLATIRIPDMATAMPAHALAPSVIHPPVFDSILQCFIFALQASAERLTEPMVPVAMRSVWISAAIEAQPGAELTVHAAAGRVGHKRAEADITAWSTDLGAERPVRVVMRGIEAVPLQHNAAAAAATGSGREICFTLDWKPDVDILEANGEAEACIRRALQPLETPALEESAAEQLRDVQLACAICITEAVKELEARPLVDEEALPDHLKKYLGWLRLIADEYENNNVLRQDASWPAIVEDAVSRDRFLAEYEASGHPEAVMICRMGRNIAPILRGDVDGLHLLFGMDDMLERVYRVAIGTQKIHALMGEYARTLSHKRGADLRVLEIGAGTGGTTTSILEAVCPTGTRVIGDSRLLKYTYTDISPSFFDTAATKLGKWKAGGVIEFKTLDIDRDVEEQGFDLASYDLVIAANCLHATSDITKTMARVNSLLKPSGKLFLQETTEQRCLESPLVFGMLAGWWAAKEDFRPWGPLLDGQGWQRVLRDAGFSDTVLELKDSPREELHVQSMVVATRPAEGEEEEQREEEATSNKQQQQKQKQKQKQLDEDDVIRRVFVIAHTTPEDVALATSVASAVSEVTKLGVSVVRFADLAQHKLTNTCCIVTMETTAPFLSSSFSEAEFSLLRHVLTTAGGLLWLTLDPHENPHMALIPGLLRTVRWERDLDGSDLLLLHLPSSAEASLVASSVVKVFKHHFAGPFLSPDRHADYLVSPDHGGLGFIQTARIVAAPPVNDFIARRTTVLQPQLQAFGADPGRSLKLHTSGPGNLDKLHFVDWPGAEQPLGGNEVQVDIKAAGLNFRDVMVAMGELANNILGYEGAGVVTHVGAEVTDVKVGDRVIAVWNGANNCLQTRTRVPRDLLARIPDTMSFEEAASIPVVFVTAYFCLYEVARLRAGETILVHAAAGGTGQAVIQLAKHLGAKVYATVSSREKRTLLMDEYGLAEDHIFSSRDLSFADGVMRMTDGKGVDVIVNSLSGEALRASFGCIAMFGRFVEIGKRDIMANSKIGLLPFSRCATFTAVDLAQITTLARPLASRIMRSVVDLHAAGTLHACRPLNVHTFGEMEDAFRILQQGKHTGKVVLTAHPEDLVKVVPKPPAPTRLRPDATYLLPGGAGGLGRSIAKWMAGPAQGAKNLVFLSRSGADAATTRELLAELAAAGVRATALKCNVADEAQLVAALAELARLGFPRVAGVIQGAMQLRDSAFEFMSHAQWEECLGPKVQGTWNLHKHLPADMDFFVMLGSVAGLVGNRGQSNYAAGNTFQDALAIHRRARGLAATCIDLCNVMSVGFVAENQETLNKNPLFFYAHDGIREEEFLSLVEFHLDAERAGCRGRPQIGVGLAPLSVFKERGLPEPTFIKSPLFRQLRSTSGESGAAADAVAGADQNGAVTVRHALKFAESPEAAADIICDALVKRISRTMRIPEPDIDVGKPIHVYGVDSLVAMEIRNYLASECGSAIAVLEIMGNKSIEVLSGEIAKGSKLVSTKCKERSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XQJ6</accession>
    <name>A0A1B7XQJ6_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_14593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000012">
        <property type="protein sequence ID" value="OBR02021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018150539.1">
        <property type="nucleotide sequence ID" value="XM_018309567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XQJ6"/>
    <dbReference type="GeneID" id="28873674"/>
    <dbReference type="KEGG" id="chig:CH63R_14593"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_14593"/>
    <dbReference type="OrthoDB" id="4851570at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008600942" evidence="2">
        <location>
            <begin position="24"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR02021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="807" mass="87662" checksum="10EB3AEC1D5ADB1A" modified="2016-11-02" version="1">MPTPSLSLSISWWIVYLADHVNGEQNRESYVLRGQTLGQLRTTTSCRLTWRASDQVLKKSFLAFFRLSKHDVKALSTLPEGVVVPEGANKKSKRTLRALAETMNINVDFLTTEEWSALKQRLVSSLNYILDQNMKRKTLTKWFDVSLQKEVLKWPDEVRNAWIDDRWWGDDGAIAVDIKTEQDGGDDGEEEGEQDKEEDEGQQSSSEQPDTNNKNNDHNDDNNNSNNNNNNNNNGDMDDDEYDGGGWGEIRDWDHDVKVQRLKEQREKEQQALLEVSLAARPPDPPQSRRSVIRPSHAGEQAITIHDGDDNNERGGDSDVEMSDWIHRERSHQKEARPEASSAIRRTPPLPAASRRPAGPAPHRIQTAPQHPFAVTRPIRPDPHPDPHPDPHPSNNPFGAVHPAAVSRPTPKSAFAYTSALPDRNLFAFSLQQQNSSRPNSLSRAAAAAAAAAMQTGPPPPSPPPPKYPNPHAAVPPKTPVRPLRLVAALQNRSQPDPQRPASAVHSRPSPPPSPHHHSVIHHRAQPNTTGTLAAAAAVGNARPRPSYPDPRPFASVPPPLPASFGLLAPSALPPPVISPSKIQQSGGGNNTQTVALFPQRHEHNGPHTTAFAPAHNDREAAARHPTAPTPAETVAATAVANLASPTGVAGPLADLGQAERLFRHRAVHQAEAYFDTIGTLASWASASASSSAPPEARDCNVLLLLASLAVAPILPLVPPSNNRMAPAFLQSASTPLGRASVDLQWAFEARNSAAKTASSALRRAGLLFHPPMDAVEAATQDTGRLTPLCLNLPWWASPGFATIVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XU15</accession>
    <name>A0A1B7XU15_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_12373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018151764.1">
        <property type="nucleotide sequence ID" value="XM_018307347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XU15"/>
    <dbReference type="GeneID" id="28871454"/>
    <dbReference type="KEGG" id="chig:CH63R_12373"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12373"/>
    <dbReference type="OrthoDB" id="4848569at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR03246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="614" mass="69219" checksum="4B534EC95DAD6185" modified="2016-11-02" version="1">MALACVPSRCGLCGFEFECADWMVVSRLHSPHLSAICLLTYVYVVKDDGQQSRVMYHAILWSNIQDAIFKPCRWKCSHSGGRAKGCHAKCANQVPSTSLAVLLKALAYQHEPLPFEIARRIRWICLQYASRAPVLKHAKPHLPQELRFQIARHLLQGPTLHRYAAECTQTLLKYQGSGSSRICLSAEIWARFIHFEGGRYISSLRNSRDDDHTESIFTPDLTQSIDSVFIAENYLGVTKILFCSSFQAPSIKARDGLWWRVIRLCDHDQTLITQTDGFKLRTIALDNEETESRANHPLWSVPALGPVRSVQLGIGPPPAKLSMLVCNEPDVIAYSAFWTVGIMSLHAHTTGGDLAPYNRHEEGIWLYFPLEKGEKISEIWNLSQFLEGSALIFKTTHGRLAIFGPRFIPRTKPLPQSTLLDLPHQERGSRIFYEHSPRMVFHLAFETAKPVPPSRSITLNQPLSQNPISSLSKPYFYSAASLDCVDTIVPCQRYIDGRRHIIGLLLKFPEGRQSCVGQIRLDSLGNPIQAYSIQNLWIGFSLYRRRLFVSALTLSEPNLTEGLSWLKVQLHGTLEWWFSSTQCQLHHMGKSSPEPRHYSCRGGGDSGNLSGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XV22</accession>
    <name>A0A1B7XV22_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AT hook domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CH63R_12715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152106.1">
        <property type="nucleotide sequence ID" value="XM_018307689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28871796"/>
    <dbReference type="KEGG" id="chig:CH63R_12715"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12715"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="176"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="900"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1331"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1406"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OBR03588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="1431" mass="159370" checksum="43285FBBBC3ADB11" modified="2016-11-02" version="1">MPTSMHPQAKFDPIPPDLDLHTLVDRTPNFEWVLRISTAQIQGLGPQEFEKLVQLQVIQGGKPLVIEKWNDVLPQRLFSGEWLEKTYDKKQENVRDITAQTEIPMTTGHYIRAMKQLANQWTPTNYRDERRQRLYLKDIDCPPEWHEHLQKVIPPNLFYMNENVTQKGVADQRNNDVFRGLNDRATVAPAGDLMSSLPEEMRAQNLMCYIGHEGTFTPAHREMCASLGQNIMVEASGSENGETPGSSIWFMTETKDREVVREYFISMLGHDIEIEKHFAQINAWKKATFPVYIVEQKPGDFILIPPLAPHQVWNRGTRTMKVAWNRTTVETLDMALHEALPKARLVCRDEQYKNKAIIYYTLKKYYQQMVQAEEKAEMGILGLGSELFRSSSRYKQLAKDFRHLFSLFTEVLVDEMFATKEKNIEYVEYDSCVTCSYCRSNIFNRFLTCKSCVRTLVNGDEDAYDVCMECYAMGRSCVCISRLQWCEQWQWSELTDNYELWRSMIIKNDGFIDIELSPQPLEIARSRRGKKSLAEICQEGLRRRPFKDISKLEEQKQLSESEPEPEVDDNGKPKKRKYKRKKKKGELRRCHSCCHKDYAYKVHICSNPDCKEGYCYGVLYRAFDMMPQTVQENENWICPKCLGICNCGACRRAGDTNPYTPKNTLLGHDTRAIADDRSVEALVDFRSHNLNWLKTAGEEGRSTNSKRMKELREKADTAKAQETAAITAEDIANGVNHPAESVERNIDGYGDQNHVLGEQDVQMQDQSFLDGDQDLSQMDHDQSVPFADMGTNGGWDQSAYPDPLDGQRMFGMGYYEQDGPDQILFDPFQMPSADAMVFDDEAEFIRKTLRAQKRKAKHENEFDPDFNAPRSHHRKKQKKPELGDISSMDPALFGAPPAAPSTTDATGEAGSAGSAEASVAPEDPSSVQLEREGAQAAEGQRQKSGYTAPQYPANVPSLRHARPKASYAEPEEPMIDDPDDIVPATKQRPLIQNDELRAGDSTANPLNLATDAVRALVEQEASGANDTASETPKVPKRRGRPPKSANSTPASATRAAAAPKSTPADLAAKKREERASRRSGLSRVVTIDGASFFNPRSQDRLSDDDLDAAHDVTEAELEAELDRELAGERPQNTPITSIETKAAEATVQPIKKRRGRPPKNKAANATPAETDPADRSPPPPPAGASRMMSMAARVAARGGKFKMTSRKSRDRSTKESPVPTQALSESGRQSRGRSEQQPDIAPVEEPVREPSREPSLDLTPPPPNATAEHKEPSEDPASPPLATRQRELSSDHTPPPPGARQRVSSPDHTPSPPGAVSRPWRKSDEDDEASDYAAPAASLSSASSSDSGIPDASPPPPPARPGRPSTGLTVVRLGESESESEISSSSESESGIGESLGISGGVSSRGRGRGRGRGRGRGRGRGRGRGRGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XVJ1</accession>
    <name>A0A1B7XVJ1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kish</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_12914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR03787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152305.1">
        <property type="nucleotide sequence ID" value="XM_018307888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XVJ1"/>
    <dbReference type="GeneID" id="28871995"/>
    <dbReference type="KEGG" id="chig:CH63R_12914"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12914"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601116" evidence="9">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR03787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="107" mass="12083" checksum="52230169F06C7D3E" modified="2016-11-02" version="1">MTALFNFQSLLLVILLLVCTCAYVHQLIPAIMDRNKDGHLFLAYRNEGTRSLTVRQLHWHLLEICKGGRAVKSVHQLMLRRYGGKSSPVCPHGRTANRALQASMLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XWE5</accession>
    <name>A0A1B7XWE5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pfs domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_13208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000009">
        <property type="protein sequence ID" value="OBR04081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152599.1">
        <property type="nucleotide sequence ID" value="XM_018308182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XWE5"/>
    <dbReference type="GeneID" id="28872289"/>
    <dbReference type="KEGG" id="chig:CH63R_13208"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_13208"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="391"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="808" mass="90143" checksum="D1E6FE5C59699AB6" modified="2016-11-02" version="1">MSDPLLYTIGWICAIVPEFVAARLFLDEEHEYPVSVSKHDSNSYKLGRIGKHNVVIAVLPHGEYGLNSAATVARDMLHTFENVKVGLMVGVGGGAPSTKNDIRLGDIVVSSPGDGHGGVFQYDFGKSLHSGRFRTTGFLNKSPTALMTALNSLISDIEIKGNWLGDDIDKALRSKSLKQKYGRPDPESDMLFRSEVAYDADKTLTEYGPEDVVKRPKRDEGEGPVIHYGLIASANQVMKDPCKRDALAAEKNVLCFEMEAAGLVNHFPCLVIRGICDYSDTHKNKQWQGYAAMAAAAYAKALVCRLQESRLEHERRILEIPQVLSLLENVKQSVSEIKTRVDHAILGELSVAAGAEYDTHHNEHDPTCHPETRIDIIHEIERWASDADGPRMYWLSGMAGTGKSTIARTVARKFDDMHMLAASFFFKRGEMDRSRASLLFSTIARQLVSHRQELLPFVLEAIKKTDNISSKSTREQFSKLVLDPLHKARTGQRGKPKMLLVLDALDECSAEKDIETVVPLLAKLVKCKGYDIKVFVTSRPELAIHYAFDRTKGLHEEIQLHRVSQDTISHDIGVYLRDELAQIKKVWNARYPECSSRHLSVDWPGDENLEALVHMTNPLFIFAATACRLIRDHHYGDPDQQLSTLLRASKESGVNDKLGPTYLPALRQFRDGRTGLEKGRMLLRFRRIFGTIILLEESLSIVSIAGLVGVEEREVERVLGLLSSVIDVPRSPNSPVSLFHLSFREFLLGSGAEDFAIECTAAHQQIALGCLDLLSNRQPLRYNILSKFISSTGSRLSASWAKRAKQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXB1</accession>
    <name>A0A1B7XXB1_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CH63R_11101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018152916.1">
        <property type="nucleotide sequence ID" value="XM_018306075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXB1"/>
    <dbReference type="GeneID" id="28870182"/>
    <dbReference type="KEGG" id="chig:CH63R_11101"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11101"/>
    <dbReference type="OrthoDB" id="3436860at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OBR04398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="166" mass="18756" checksum="BCD2DB3D1F73C612" modified="2016-11-02" version="1">MGIRDFFDGRFFDTRYRTKVHILQLVLMTVAIILTIARMAMPVPTTRANMMALTMGLKSLIIIGYQLLTTHKQRFKKWASLKANAILNTIEIVFWFVAFGLLCSANGTFCTGASCALSWVVTLIVMVLIVLAFQTSVVSIKDYRYFKNYGVNPETESRAAYPKPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XXW3</accession>
    <name>A0A1B7XXW3_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CH63R_11309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IMI 349063</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153124.1">
        <property type="nucleotide sequence ID" value="XM_018306283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XXW3"/>
    <dbReference type="GeneID" id="28870390"/>
    <dbReference type="KEGG" id="chig:CH63R_11309"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11309"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OBR04606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="536" mass="60844" checksum="A30C4D3DB0103665" modified="2016-11-02" version="1">MAAQITGFTAQFWSFRMISMVCIGLPALGLAYLFVNVIYNIYFHPLRRYPGPKLWAATRIPYTRSSLSGQVHRRILALHREYGPVVRIAPDELAYNHPDAWRDIHGHLKNGTGDHGRDPVFTVESRHSIIGAAREDHSRFRRALSHGFSAQSMAKQEPIIKGYVDLLLRKLQEKSAGGTRSLDMVSWYNWTTFDIIGDLAFGEPFNCLDDSDYHPWVKLIFESVKAGTFRLNARRYPLVEKLLMNFLPANLKRKRAQHVALTHEKVTKRLSAKSARPDFMDSMLRKTDARELTFDELKSNASTLIIAGSETTATALSGITYFLLSDANVHRKLNDEIRGAFASEGEINMVSVQKLGYLQAVINEGLRMYPPVPTGITRRVTDDGGVFLGQYVPSGKTMRSPRFVKGATKENEMLTEEGKTKQALVQVWHWPAYHDPENFTLPDSFIPERWLNDPRFAGDRRDGFQPFTVGPMNCIGRNLAYAEMRLILARLLWNFDMTLAEDSKGWYERSKVYMLWEKGPVNVVLVPRDLGSGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XY77</accession>
    <name>A0A1B7XY77_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor tfiiic complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_11430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153245.1">
        <property type="nucleotide sequence ID" value="XM_018306404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XY77"/>
    <dbReference type="GeneID" id="28870511"/>
    <dbReference type="KEGG" id="chig:CH63R_11430"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11430"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="633"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OBR04727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="740" mass="80895" checksum="7EE88228B2BF54DB" modified="2016-11-02" version="1">MVRTRPRNKTKRIAVIDYGSDGEPPEAHDDSDDENFEAPPPDPEDDEDDPMDVDGGDDDFEAEDPSQLVIDVNGNNDDEDERPAYTSSAGLRKRPTDMAALGTYHADGRPTRHYTGALKRGQRIQVLDFFYGPQEEAVGVASWLLNRWAGYPVLPSKLPDGPAPPVPSPWLEPGFVEDQDRAAKSWFARLGDGEGASRGEREMSTEEAAQYRLDPGGHLVSVIGPYPDQQEVDIAPYGGVALTMSGLPLTGEKAEEEKSAGWMFDVGGIVIGMDWARRTGQEAQVLALAVIPHTDQQLDFEDAYDEKKGIVQLWELCGQKGDDGITRPLGRPARLARTVCFDWGRVLRLKWCPTPYRENGAMGLLAVLCGDGQVYIVVVKDIHNDEQDVFTKLETPVVSLGLPAETDVTATCFAWVNTNRIVLGHSDGSLTLWSVSPRILLARHDVHSTRVMHIDTAYPSDPYLVASTPVAGYTTLVDLSDPSCERTSFPCFAITPQPNLLQWQDHLRGFFTVVPSANPLNASVGFVHSRWYAAQVRKAMDGDRLPTCLAAGLHHPFVLVGYMDGTVWAANPSNRIFASKHHFGHKMKVVDHQYIPRARLAGPVLERVGDGGDAGGRCRGASRILQGFRPVPNVNPKVDTWKTKGAIGKKKENKKGKGKKTKTKAKGKAGAEDDDDDDADVQGGAEEGDGHFADPKRAVLSEPLTRITTMAWNPNGEYSCWAAVAMASGLVRVMDLGLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XYY1</accession>
    <name>A0A1B7XYY1_COLHI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_11669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR04966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153484.1">
        <property type="nucleotide sequence ID" value="XM_018306643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XYY1"/>
    <dbReference type="GeneID" id="28870750"/>
    <dbReference type="KEGG" id="chig:CH63R_11669"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_11669"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR04966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="212" mass="23461" checksum="04E8E8F8CBAF6FA5" modified="2016-11-02" version="1">MSRSLLRSVLELRTPITRLPPTFLLPTHARRYNSTAPIVEPVAHKAPTVTPLDTPTKPSIAQQAQAAAVDTAASAATAAPIPESVQAVLPFLAAQPNHYITFHIHGRPYLVQPGDSIRLPFKMPGVVPGDVLRLNRASVIGSRDYTLKGAPFIDERVFECRAVVTGTESEPMRLKTKTKRRQRRVKTVKSKHRHTMLTVSELKINRVEEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7XZZ7</accession>
    <name>A0A1B7XZZ7_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CH63R_12032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IMI 349063</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000008">
        <property type="protein sequence ID" value="OBR05329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018153847.1">
        <property type="nucleotide sequence ID" value="XM_018307006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7XZZ7"/>
    <dbReference type="GeneID" id="28871113"/>
    <dbReference type="KEGG" id="chig:CH63R_12032"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_12032"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008601227" evidence="2">
        <location>
            <begin position="33"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OBR05329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000092177"/>
        </source>
    </evidence>
    <sequence length="458" mass="51057" checksum="FB8644D97D2370A7" modified="2016-11-02" version="1">MNGPALLPQHISHRLWFSLFIQLSLELILTLSRHNPNTSLPQSRTRHRLTVTVASYSSSNTDEEPEHLPYPATKLIIAQYWHCSRDPPFWGYLIVGTFYDQHNNIVWSTEIFAFQPDPRRRQDTPSVASSEPDVDSASNNDLNDQFARSLNLAHSTHRPRDQAYAPRYPYHHHPHGQQLWNPALAGPVPGHWVTEYNHQLDTHSHTHAHILTLENNHKTNLNMSNPVNGHDMDPRRPLFSPNNGVPMPRYGEAYIPPAGGYGNYYQYPYAASYGPPAPYPGSTAYMWPNPQHAGGYNTYPLQPGGQASYGARAAQGLPTLDPRNPAAHLGNSTGGTGCEPGYNYFFPAAHTKIHVFRTSTPPWQLPANARVPFAAFHVPVNTTLAEVLKGFGALNPNPKKNKCFEIVQAGNGKWYKGLCFAGDDKDMMKKSIADIGWDAGRTGLPGQKPVVCVWLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B7Y0U5</accession>
    <name>A0A1B7Y0U5_COLHI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CH63R_09747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Colletotrichum higginsianum (strain IMI 349063)</name>
        <name type="common">Crucifer anthracnose fungus</name>
        <dbReference type="NCBI Taxonomy" id="759273"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Glomerellales</taxon>
            <taxon>Glomerellaceae</taxon>
            <taxon>Colletotrichum</taxon>
            <taxon>Colletotrichum destructivum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2017" name="BMC Genomics" volume="18" first="667" last="667">
            <title>Gapless genome assembly of Colletotrichum higginsianum reveals chromosome structure and association of transposable elements with secondary metabolite gene clusters.</title>
            <authorList>
                <person name="Dallery J.-F."/>
                <person name="Lapalu N."/>
                <person name="Zampounis A."/>
                <person name="Pigne S."/>
                <person name="Luyten I."/>
                <person name="Amselem J."/>
                <person name="Wittenberg A.H.J."/>
                <person name="Zhou S."/>
                <person name="de Queiroz M.V."/>
                <person name="Robin G.P."/>
                <person name="Auger A."/>
                <person name="Hainaut M."/>
                <person name="Henrissat B."/>
                <person name="Kim K.-T."/>
                <person name="Lee Y.-H."/>
                <person name="Lespinet O."/>
                <person name="Schwartz D.C."/>
                <person name="Thon M.R."/>
                <person name="O'Connell R.J."/>
            </authorList>
            <dbReference type="PubMed" id="28851275"/>
            <dbReference type="DOI" id="10.1186/s12864-017-4083-x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IMI 349063</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LTAN01000007">
        <property type="protein sequence ID" value="OBR05627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018154145.1">
        <property type="nucleotide sequence ID" value="XM_018304721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B7Y0U5"/>
    <dbReference type="GeneID" id="28868828"/>
    <dbReference type="KEGG" id="chig:CH63R_09747"/>
    <dbReference type="VEuPathDB" id="FungiDB:CH63R_09747"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000092177">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
  
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